CN106491769A - The Traditional Chinese medicine compound gel agent for the treatment of wound, preparation method and applications - Google Patents
The Traditional Chinese medicine compound gel agent for the treatment of wound, preparation method and applications Download PDFInfo
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- CN106491769A CN106491769A CN201611269639.5A CN201611269639A CN106491769A CN 106491769 A CN106491769 A CN 106491769A CN 201611269639 A CN201611269639 A CN 201611269639A CN 106491769 A CN106491769 A CN 106491769A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Landscapes
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- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Traditional Chinese medicine compound gel agent for treating wound, preparation method and applications.The Traditional Chinese medicine compound gel agent of the treatment wound that the present invention is provided adopts Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi, Fructus Gardeniae, seven taste crude drug of Radix Sanguisorbae and Herba Menthae, obtain Chinese medicine extract, and which is further made Traditional Chinese medicine compound gel preparation, have functions that heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, reducing swelling and alleviating pain, hemostasia and promoting granulation.Meanwhile, the Traditional Chinese medicine compound gel agent antibacterial of the treatment wound that the present invention is provided is strong, relieve the pain fast, good effect, short treating period, have no toxic side effect, more after do not stay scar, cure rate height, can be widely applied to the aspects such as burn and scald, infectious trauma and decubital ulcer.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, more particularly to a kind of Traditional Chinese medicine compound gel agent for treating wound, preparation
Method and its application.
Background technology
People are often subject to some unexpected injuries, such as traumatic injury, burn, scald, skin in daily life and production
Skin ulcer etc..As cured not in time, pathogenic factor and antibacterial invade, and can not only expand wound surface, can also cause wound bleeding, infection, change
Pus, can seriously obtain tetanus, or even life-threatening.In addition, wound mostly occurs at Human body package position, more after cicatrix damage and suffer from
The appearance of person, has undesirable effect to the psychology of patient.
The medicine of existing treatment wound has a lot.By having an injection and taking Western medicine, sterilization, sterilization, analgesic work is played
With, but there is also certain shortcoming：Typically all contain antibiotic, although short time interior energy palliates the agonizing sufferings, but which has significantly
Side effect, and expensive.Also there are some Chinese powder medicines, unguentum and oil preparation on the market, but which exists using inconvenience, absorbs
Slowly, treatment time length, therapeutic effect be poor, problem that is can leaving certain cicatrix more afterwards.
Content of the invention
It is an object of the invention to provide a kind of antibacterial is strong, relieve the pain fast, good effect, short treating period, have no toxic side effect and more after
Do not stay the Traditional Chinese medicine compound gel agent of the treatment wound of scar, the Traditional Chinese medicine compound gel agent pass through by Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali,
Cacumen Platycladi, Fructus Gardeniae, seven taste crude drug reasonable compatibility of Radix Sanguisorbae and Herba Menthae, with heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, reducing swelling and alleviating pain, hemostasis
Effect of granulation promoting.
Second object of the present invention is to provide a kind of preparation method of Traditional Chinese medicine compound gel agent, and the method can be maximum
Remain to limit the drug effect of each taste crude drug, while by Chinese medicine extract is made gel so that medicine dispersion effect and
Good absorbing effect, and have the advantages that appearance looks elegant, be difficult pollution clothes, be readily cleaned, easy to use.
Third object of the present invention is to provide a kind of Traditional Chinese medicine compound gel agent in burn and scald, infectious trauma and decubital ulcer
The application of aspect.
For achieving the above object, the technical solution used in the present invention is：
A kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, the Chinese medicine extraction
Thing is prepared from by the raw material of following weight portion：Flemingia macrophylla 30-50 parts, Radix Angelicae Sinensis 15-25 parts, Radix Astragali 10-20 parts, Cacumen Platycladi
5-15 parts, Fructus Gardeniae 5-15 parts, Radix Sanguisorbae 5-15 parts and Herba Menthae 2-6 parts.
Further, the Chinese medicine extract is prepared from by the raw material of following weight portion：Flemingia macrophylla 35-45 parts,
Radix Angelicae Sinensis 17-23 parts, Radix Astragali 12-18 parts, Cacumen Platycladi 8-12 parts, Fructus Gardeniae 8-12 parts, Radix Sanguisorbae 8-12 parts and Herba Menthae 3-5 parts.
Preferably, the Chinese medicine extract is prepared from by the raw material of following weight portion：40 parts of Flemingia macrophylla, Radix Angelicae Sinensis 20
4 parts of part, 15 parts of the Radix Astragali, 10 parts of Cacumen Platycladi, 10 parts of Fructus Gardeniae, 10 parts of Radix Sanguisorbae and Herba Menthae.
Preferably, the Flemingia macrophylla is the wild Flemingia macrophylla in Hainan.
Further, the gel forming agent include by weight gel-type vehicle 50-80 parts, wetting agent 200-300 parts,
Preservative 2-4 parts, surfactant 5-10 parts and purified water 400-600 part.
Preferably, the gel-type vehicle is carbomer.
Preferably, the wetting agent is glycerol.
Preferably, the preservative is hydroxy methacrylate.
Preferably, the surfactant is polyoxyethylene sorbitan monoleate.
Further, the weight ratio of the Chinese medicine extract and gel forming agent is 1：4-8.
A kind of preparation method of above-mentioned Traditional Chinese medicine compound gel agent, comprises the following steps：
(1) Chinese medicine extract is prepared：Weigh Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi, Fructus Gardeniae, seven taste of Radix Sanguisorbae and Herba Menthae
Crude drug mixes, and takes decocting cooking method to be extracted, and is concentrated into relative density for 1.05-1.10 (60 DEG C measure), in obtaining
Medicament extract；
(2) gel forming agent is prepared：Gel-type vehicle is added in purified water, fully swelling after, add wetting agent, preservative
And surfactant, obtain gel forming agent；
(3) Chinese medicine extraction liquid is added in gel forming agent, stirring forms uniform, sticky gel, obtains middle recurrence due to taking drug
Square gel.
Further, the preparation method is comprised the following steps：
(1) Chinese medicine extract is prepared：Weigh Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi, Fructus Gardeniae, seven taste of Radix Sanguisorbae and Herba Menthae
Crude drug mixes, and adds water to cook 2-3 time, and the weight for adding water is 7-9 times of the crude drug weight, and each decocting time is 2-3
Hour, filter, merging filtrate, take supernatant standing, relative density is concentrated into for 1.05-1.10 (60 DEG C measure), obtains Chinese medicine
Extracting solution；
(2) gel forming agent is prepared：Carbomer is added in purified water, fully swelling after, add glycerol, hydroxy methacrylate and
Polyoxyethylene sorbitan monoleate, stirs, and obtains gel forming agent；
(3) Chinese medicine extraction liquid is added in gel forming agent, stirring forms uniform, sticky gel, obtains middle recurrence due to taking drug
Square gel.
Application of the above-mentioned Traditional Chinese medicine compound gel agent in terms for the treatment of traumatic injury, burn and scald and decubital ulcer.
Compared with prior art, the beneficial effects of the present invention is：
1st, the Traditional Chinese medicine compound gel agent of the treatment wound that the present invention is provided passes through Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi
Leaf, Fructus Gardeniae, seven taste crude drug reasonable compatibility of Radix Sanguisorbae and Herba Menthae, with heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, reducing swelling and alleviating pain, hemostasia and promoting granulation
Effect.
2nd, the Traditional Chinese medicine compound gel agent of the treatment wound that the present invention is provided have that antibacterial is strong, relieve the pain soon, good effect, the course for the treatment of
Short, the characteristics of have no toxic side effect, and the effect of normal healing, preventing from scar can be reached.
3rd, Chinese medicine extract is made gel by the Traditional Chinese medicine compound gel agent of the treatment wound that the present invention is provided so that medicine point
Scattered effect and good absorbing effect, at the same appearance looks elegant, be difficult pollution clothes, be readily cleaned, easy to use.
4th, the Traditional Chinese medicine compound gel agent of the treatment wound that the present invention is provided is applied widely, is applicable not only to burn and scald, sense
The wound such as metachromia wound and decubital ulcer, applies also for the reparation of some wound surface postoperative.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with accompanying drawing, it is clear that described enforcement
Example is a part of embodiment of the invention, rather than whole embodiments.Embodiment in based on the present invention, ordinary skill
The every other embodiment obtained under the premise of creative work is not made by personnel, belongs to the scope of protection of the invention.
The present invention is obtained using Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi, Fructus Gardeniae, seven taste crude drug of Radix Sanguisorbae and Herba Menthae
Chinese medicine extract, and which is further made Traditional Chinese medicine compound gel preparation, the Traditional Chinese medicine compound gel preparation antibacterial for obtaining is strong, relieve the pain
Hurry up, good effect, short treating period, have no toxic side effect, and more after without scar.
The Traditional Chinese medicine compound gel agent of the present invention, including Chinese medicine extract and gel forming agent, the Chinese medicine extract by with
The raw material of lower weight portion is prepared from：Flemingia macrophylla 30-50 parts, Radix Angelicae Sinensis 15-25 parts, Radix Astragali 10-20 parts, Cacumen Platycladi 5-15
Part, Fructus Gardeniae 5-15 parts, Radix Sanguisorbae 5-15 parts and Herba Menthae 2-6 parts.
Effect of every crude drug of the present invention is as follows：
Flemingia macrophylla, the dry root of pulse family Moghania plant Radix Flemingiae Philippinensiss, its sweet in the mouth, mild-natured, tepor are lived with wind-dispelling
The effects such as blood, relaxing muscles and tendons and activating QI and blood in the collateral, bone and muscle strengthening, anti-inflammatory analgetic, it is adaptable to which rheumatic arthralgia, lumbar muscle strain, extremity flaccidity are soft, traumatic injury is damaged
The diseases such as wound, laryngopharynx swelling and pain.《The south of the Five Ridges is gathered medicinal herbs record》Described in：" dispelling wind and eliminating dampness, brothers' arthralgia pain is controlled, lumbar rheumatism is had a pain, manage traumatic injury
Wound, can relaxing muscles and tendons and activating QI and blood in the collateral.”《Nanning City's medicine will》Described in：" strengthening bone and muscle, blood stasis removing are accumulated.Control traumatic injury, rheumatic ostalgia, extremity acid
Soft powerless, jaundice.”
Used as the preferred embodiments of the invention, Flemingia macrophylla is the wild Flemingia macrophylla in Hainan.
In the present invention, the typical but non-limiting content of Flemingia macrophylla is：30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35
Part, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts or 50
Part.
Radix Angelicae Sinensis, are the dry root of umbelliferae angelica, its sweet in the mouth, pungent, warm in nature, with replenishing and activating blood, menstruction regulating and pain relieving, profit
Effect of intestinal relieving constipation, it is adaptable to blood deficiency and yellow complexion, dizziness palpitaition, menoxenia, closed dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, fall and flutter
The diseases such as damage, ulcer sores, dry constipation of intestines.《Do not record》Described in：" warming middle-JIAO to relieve pain, except plug in objective blood, middle puerperal tetanus, no sweating are wet
Numbness, attacked by pestiferous factors is courteous, cold caused by deficiency, mend five Tibetan, granulation promoting meat.”《Detailed outline》Described in：Headache, all pains of trusted subordinate, intestine moistening stomach muscles and bones skin is controlled ".
Control carbuncle, evacuation of pus pain relieving, and blood to enrich blood.”
In the present invention, the typical but non-limiting content of Radix Angelicae Sinensis is：15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21
Part, 22 parts, 23 parts, 24 parts or 25 parts.
The Radix Astragali is leguminous plant Radix Astagali or the dry root of Radix Astragali, and its sweet in the mouth is warm in nature, with invigorating QI to consolidate the body surface resistance, support
Malicious evacuation of pus, effect of expelling pus and promoting granulation, it is adaptable to treatment deficiency of vital energy weak, lack of appetite rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema,
The symptoms such as ulcer is difficult to burst, bursts for a long time and does not holds back.《Collected statements on the herbal foundation》Described in：" Radix Astragali, tonifying the lung spleen invigorating, defend real arresting sweating, and wind dispelling transports the medicine of poison
?.”《Book on Chinese herbal medicine meets original》Described in：" all void of Radix Astragali energy tonifying five ZANG-organses, controls stringy pulse spontaneous perspiration, rushes down YIN-fire, remove lung-heat, lossless, sends out, has antiperspirant
Then stop.”
In the present invention, the typical but non-limiting content of the Radix Astragali is：10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16
Part, 17 parts, 18 parts, 19 parts or 20 parts.
Cacumen Platycladi, is that cupressaceae plant Cacumen Platycladi dries branch top and leaf, and its bitter and puckery flavor is cold in nature, stop with cooling blood for hemostasis, resolving sputum
The effect that coughs, it is adaptable to spit blood, epistaxis, spit blood, have blood in stool, metrostaxiss, cough due to lung-heat, the disease such as blood-head alopecia.《Do not record》Middle note
Carry：" main haematemesis, epistaxis, dysentery blood, metrorrhagia are red white.Make light of one's life by commiting suicide QI invigorating, make us resistance to cold and summer-heat, go arthralgia chiefly caused by damp pathogen, granulation promoting.”《Book on Chinese herbal medicine is just》Described in
" the kind removing heat from blood that purifies the blood, remuval of damp and hot arthralgia chiefly caused by damp pathogen, arthralgia.Mash and can apply erysipelas, scattered mumps swells and ache pyretic toxicity.”
In the present invention, the typical but non-limiting content of Cacumen Platycladi is：5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts,
12 parts, 13 parts, 14 parts or 15 parts.
Fructus Gardeniae, the dry mature fruit of Maguireothamnus speciosus Radix Rubiae, its bitter in the mouth are cold in nature, with purging intense heat relieving restlessness, clearing away heat-damp and promoting diuresis,
Removing pathogenic heat from blood and toxic substance from the body, effect of reducing swelling and alleviating pain, it is adaptable to the puckery pain of Vexed, jaundice due to damp-heat, stranguria, blood-head tells nosebleed, conjunctival congestion and swelling pain, fire
The symptoms such as skin infection infectionss, bruise pain.《Bencao Jingshu》Described in " Fructus Gardeniae, the heat of clear few the moon, then in five pathogen oneself go, pathogenic heat in the stomach
Gas is also removed.”《A supplement to augmented materia medica》Described in " rush down three burnt fire, clearing stomach collapse due to massive hemorrhages are controlled epigastric pain with cold limbs due to adverseness of heat, solve heat stagnation, row stagnation of QI.”
In the present invention, the typical but non-limiting content of Fructus Gardeniae is：5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12
Part, 13 parts, 14 parts or 15 parts.
Radix Sanguisorbae, is the root of Rosaceae burnet herbaceos perennial Radix Sanguisorbae, its bitter in the mouth, cold nature, with blood-stanching and blood-cooling,
Heat-clearing and toxic substances removing, astringing to arrest diarrhea and suppress effects of multiple pathogenic microorganism, it is adaptable to spit blood, dysentery, burn wound, eczema, ulcer,
Have blood in stool, metrorrhagia, the disease such as purulence ulcer.《Do not record》Described in " only pus and blood, all fistulas, malignant boil, disappear wine, except quenching one's thirst, mends and hinders absolutely, plug in puerperal,
Incised wound cream can be made.”《Book on Chinese herbal medicine is looked for the truth》Described in " its heat both pacify certainly by clear then blood, and its main convergence of property, can drop clearly, and energy astringent therapy,
Then clearly do not consider which and cross and let out, puckery also do not consider which is excessively stagnant, actually antipyretic hemorrhage.”
In the present invention, the typical but non-limiting content of Cacumen Platycladi is：5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts,
12 parts, 13 parts, 14 parts or 15 parts.
Herba Menthae, is the herb or leaf of labiate Herba Menthae, and its acrid in the mouth is cool in nature, with dispelling wind and heat pathogens, head clearing, profit
Pharynx rash, effect of soothing the liver circulation of qi promoting, it is adaptable to affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, sore scabies, addiction
Rash, epidemic febrile disease from the beginning of, rubella itch, stagnation of QI due to depression of the liver, the disease such as hypochondriac pain uncomfortable in chest.《Haigoushen》Described in：Anger gas, toxophoric antiperspirant, removing blood stasis are removed "
Dysentery relieving, easing joint movement.”《Records of Tradition Chinese and Western Medicine in Combination》Described in：" Herba Menthae acrid in the mouth, the clear YUXIANG of gas are altered, mild-natured.Its power can interior muscle thoroughly
Bone, outward up to flesh table, the logical internal organs of a surname run through meridians, and clothes can send out antiperspirant thoroughly cool, be the key medicine of the suitable cure by diaphoresis person of epidemic febrile disease.”
In the present invention, the typical but non-limiting content of Herba Menthae is：2 parts, 3 parts, 4 parts, 5 parts or 6 parts.
Clearing away heat and cooling blood, the natural plant raw material medicine of removing toxic substances sore are mainly selected in the Traditional Chinese medicine compound gel agent of the present invention, wherein,
Flemingia macrophylla expelling wind and activating blood circulation, relaxing muscles and tendons and activating QI and blood in the collateral, Chinese angelica blood supplementing promoting blood circulation, detumescence and apocenosis, Radix Astragali invigorating QI to consolidate the body surface resistance, promoting pus discharge and tissue regeneration strengthening, side primary
Leaf heat-clearing and toxic substances removing, cooling blood for hemostasis, Fructus Gardeniae clearing away heat and cooling blood, disinfecting pain relieving, Radix Sanguisorbae cooling blood for hemostasis, convergence stop pus, Herba Menthae heat-clearing and toxic substances removing,
Blood circulation promoting and blood stasis dispelling.By seven taste crude drug, skim the cream off milk, after scientific compatibility, mutually cooperate with, treating both the principal and secondary aspects of a disease, with heat-clearing and toxic substances removing,
Cool the blood dissipate blood stasis, reducing swelling and alleviating pain, effect of hemostasia and promoting granulation, can at short notice alleviating pain and detumescence, hemostasia and promoting granulation and more after do not stay scar
Trace.
In the present invention, the Chinese medicine extract is prepared from by the raw material of following weight portion：Flemingia macrophylla 35-45 parts,
Radix Angelicae Sinensis 17-23 parts, Radix Astragali 12-18 parts, Cacumen Platycladi 8-12 parts, Fructus Gardeniae 8-12 parts, Radix Sanguisorbae 8-12 parts and Herba Menthae 3-5 parts.
Used as the preferred embodiment of the present invention, the Chinese medicine extract is prepared from by the raw material of following weight portion：Greatly
4 parts of 40 parts of leaf Radix Flemingiae Philippinensiss, 20 parts of Radix Angelicae Sinensis, 15 parts of the Radix Astragali, 10 parts of Cacumen Platycladi, 10 parts of Fructus Gardeniae, 10 parts of Radix Sanguisorbae and Herba Menthae.
Above-mentioned raw materials medicament extract is made gel by the present invention.Gel refers to the tool that extract is made with proper amount of matrix
There is the semi-solid or glop of gel characteristic.Gel has slow releasing function to drug release, and stretchability is good, after local is administered
Easily absorb, at the same also have appearance looks elegant, be difficult pollution clothes, be readily cleaned, stability is preferable, easy to use the features such as.
The gel forming agent gel forming agent of the present invention includes gel-type vehicle 50-80 parts, wetting agent 200- by weight
300 parts, preservative 2-4 parts, surfactant 5-10 parts and purified water 400-600 part.
In the present invention, the typical but non-limiting content of gel-type vehicle is：50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts
Or 80 parts.
In the present invention, the typical but non-limiting content of wetting agent is：200 parts, 220 parts, 250 parts, 270 parts, 300 parts,
320 parts, 350 parts, 370 parts or 400 parts.
In the present invention, the typical but non-limiting content of preservative is：2 parts, 3 parts or 4 parts.
In the present invention, the typical but non-limiting content of surfactant is：5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts.
In the present invention, the typical but non-limiting content of scarvenger is：400 parts, 420 parts, 450 parts, 470 parts, 500 parts,
520 parts, 550 parts, 570 parts or 600 parts.
The selection of gel-type vehicle is crucial, affects drug release and the rheological characteristic of gel.The present invention from gel-type vehicle is
Carbomer, carbomer are the high molecular polymers being crosslinked with acrylic deer sugar by acrylic acid, with stronger hygroscopicity, to skin
Skin is nonirritant, forms transparent membrane after painting, heat-resisting, cold-resistant good.Smooth as gel prepared by gel-type vehicle with carbomer
Exquisiteness, tack are strong, can extend medicine and skin action time.In preparation process, carbomer can be spread on the water surface, be placed
For a period of time, after which is fully swelling, then neutralization is stirred, is so not easily formed insoluble micelle, medicine disperses more
Uniformly.
Used as the preferred embodiments of the invention, carbomer selects the Acritamer 940 that concentration is 1.0%, 1.25%, 1.5%.
During using this gel-type vehicle, dispersion of medicine, the gel without layering, hydration phenomena and formation are fine and smooth uniform, and denseness is moderate.
In the present invention, wetting agent selects glycerol, preservative to select hydroxy methacrylate, surfactant to select polyoxyethylene sorbitan monoleate.
The gel forming agent of the present invention is good with the Chinese medicine extract compatibility, and stretchability is good and skin affinity is good, energy
Enough extend and skin action time, contribute to medicine and be absorbed by the skin, and to no skin irritation.
The weight ratio of the Traditional Chinese medicine compound gel agent of the present invention, Chinese medicine extract and gel forming agent is 1：4-8.
In the present invention, gel forming agent for the typical but non-limiting multiple of Chinese medicine extract weight is：4 times, 5 times, 6
Again, 7 times or 8 times.
" including " of the present invention, it is intended which removes described group exceptionally, other components, these other components can also be included
Give the Traditional Chinese medicine compound gel agent different characteristics.In addition, " including " of the present invention, may be replaced by closing
" for " of formula or " by ... constitute ".
Technical scheme is described further below in conjunction with embodiment 1-5.
Embodiment 1
A kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, wherein：
Chinese medicine extract is prepared from by the crude drug for including following weight portion：40 parts of Flemingia macrophylla, 20 parts of Radix Angelicae Sinensis, Huang
4 parts of 15 parts of stilbene, 10 parts of Cacumen Platycladi, 10 parts of Fructus Gardeniae, 10 parts of Radix Sanguisorbae and Herba Menthae；
Gel forming agent includes that 60 parts of carbomer, 250 parts of glycerol, 3 parts of hydroxy methacrylate, polyoxyethylene sorbitan monoleate are by weight
8 parts and 500 parts of purified water；
The weight ratio of Chinese medicine extract and gel forming agent is 1：5.
The preparation method of the Traditional Chinese medicine compound gel agent of the present embodiment, comprises the following steps：
(1) Chinese medicine extract is prepared：Weigh 40 parts of Flemingia macrophyllas of crude drug, 20 portions of Radix Angelicae Sinensis, 15 portions of Radixs Astragali, 10 portions of Cacumen Platycladis
Leaf, 10 portions of Fructus Gardeniaes, 10 portions of Radix Sanguisorbaes and 4 parts of Herba Menthae mixing, add water to cook 3 times, and the weight for adding water is the 8 of the crude drug weight
Times, each decocting time is 2 hours, filters, merging filtrate, takes supernatant standing, is concentrated into relative density for 1.05-1.10
(60 DEG C measure), obtains Chinese medicine extraction liquid；
(2) gel forming agent is prepared：The Acritamer 940 that concentration is 60 part 1.25% is added in 500 parts of purified water, fully
After swelling, 250 parts of glycerol, 30 parts of hydroxy methacrylates and 8 parts of polyoxyethylene sorbitan monoleates added, is stirred, is obtained gel forming agent；
(3) weight ratio according to Chinese medicine extract and gel forming agent is 1：5, by Chinese medicine extraction liquid be added to gel into
In type agent, stirring forms uniform, sticky gel, obtains Traditional Chinese medicine compound gel agent.
Embodiment 2
A kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, wherein：
Chinese medicine extract is prepared from by the crude drug for including following weight portion：35 parts of Flemingia macrophylla, 17 parts of Radix Angelicae Sinensis, Huang
3 parts of 18 parts of stilbene, 8 parts of Cacumen Platycladi, 8 parts of Fructus Gardeniae, 12 parts of Radix Sanguisorbae and Herba Menthae；
Gel forming agent includes that 50 parts of carbomer, 200 parts of glycerol, 3 parts of hydroxy methacrylate, polyoxyethylene sorbitan monoleate are by weight
7 parts and 400 parts of purified water；
The weight ratio of Chinese medicine extract and gel forming agent is 1：6.
The preparation method of the Traditional Chinese medicine compound gel agent of the present embodiment, comprises the following steps：
(1) Chinese medicine extract is prepared：Weigh 35 parts of Flemingia macrophyllas of crude drug, 17 portions of Radix Angelicae Sinensis, 18 portions of Radixs Astragali, 8 portions of Cacumen Platycladis
Leaf, 8 portions of Fructus Gardeniaes, 12 portions of Radix Sanguisorbaes and 3 parts of Herba Menthae mixing, add water to cook 3 times, and the weight for adding water is 8 times of the crude drug weight,
Decocting time is 2 hours every time, filters, merging filtrate, takes supernatant standing, is concentrated into relative density for (60 DEG C of 1.05-1.10
Measure), obtain Chinese medicine extraction liquid；
(2) gel forming agent is prepared：The Acritamer 940 that concentration is 50 part 1.25% is added in 400 parts of purified water, fully
After swelling, 200 parts of glycerol, 3 parts of hydroxy methacrylates and 7 parts of polyoxyethylene sorbitan monoleates added, is stirred, is obtained gel forming agent；
(3) weight ratio according to Chinese medicine extract and gel forming agent is 1：6, by Chinese medicine extraction liquid be added to gel into
In type agent, stirring forms uniform, sticky gel, obtains Traditional Chinese medicine compound gel agent.
Embodiment 3
A kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, wherein：
Chinese medicine extract is prepared from by the crude drug for including following weight portion：45 parts of Flemingia macrophylla, 23 parts of Radix Angelicae Sinensis, Huang
5 parts of 12 parts of stilbene, 12 parts of Cacumen Platycladi, 12 parts of Fructus Gardeniae, 8 parts of Radix Sanguisorbae and Herba Menthae；
Gel forming agent includes that 70 parts of carbomer, 300 parts of glycerol, 4 parts of hydroxy methacrylate, polyoxyethylene sorbitan monoleate are by weight
10 parts and 600 parts of purified water；
The weight ratio of Chinese medicine extract and gel forming agent is 1：7.
The preparation method of the Traditional Chinese medicine compound gel agent of the present embodiment, comprises the following steps：
(1) Chinese medicine extract is prepared：Weigh 45 parts of Flemingia macrophyllas of crude drug, 23 portions of Radix Angelicae Sinensis, 12 portions of Radixs Astragali, 12 portions of Cacumen Platycladis
Leaf, 12 portions of Fructus Gardeniaes, 8 portions of Radix Sanguisorbaes and 5 parts of Herba Menthae mixing, add water to cook 3 times, and the weight for adding water is 8 times of the crude drug weight,
Decocting time is 2 hours every time, filters, merging filtrate, takes supernatant standing, is concentrated into relative density for (60 DEG C of 1.05-1.10
Measure), obtain Chinese medicine extraction liquid；
(2) gel forming agent is prepared：The Acritamer 940 that concentration is 70 part 1.25% is added in 600 parts of purified water, fully
After swelling, 300 parts of glycerol, 4 parts of hydroxy methacrylates and 10 parts of polyoxyethylene sorbitan monoleates added, is stirred, is obtained gel forming agent；
(3) weight ratio according to Chinese medicine extract and gel forming agent is 1：7, by Chinese medicine extraction liquid be added to gel into
In type agent, stirring forms uniform, sticky gel, obtains Traditional Chinese medicine compound gel agent.
Embodiment 4
A kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, wherein：
Chinese medicine extract is prepared from by the crude drug for including following weight portion：42 parts of Flemingia macrophylla, 19 parts of Radix Angelicae Sinensis, Huang
4 parts of 16 parts of stilbene, 9 parts of Cacumen Platycladi, 11 parts of Fructus Gardeniae, 9 parts of Radix Sanguisorbae and Herba Menthae；
Gel forming agent includes that 65 parts of carbomer, 250 parts of glycerol, 3 parts of hydroxy methacrylate, polyoxyethylene sorbitan monoleate are by weight
8 parts and 450 parts of purified water；
The weight ratio of Chinese medicine extract and gel forming agent is 1：5.
The preparation method of the Traditional Chinese medicine compound gel agent of the present embodiment, comprises the following steps：
(1) Chinese medicine extract is prepared：Weigh 42 parts of Flemingia macrophyllas of crude drug, 19 portions of Radix Angelicae Sinensis, 16 portions of Radixs Astragali, 9 portions of Cacumen Platycladis
Leaf, 11 portions of Fructus Gardeniaes, 9 portions of Radix Sanguisorbaes and 4 parts of Herba Menthae mixing, add water to cook 3 times, and the weight for adding water is 8 times of the crude drug weight,
Decocting time is 2 hours every time, filters, merging filtrate, takes supernatant standing, is concentrated into relative density for (60 DEG C of 1.05-1.10
Measure), obtain Chinese medicine extraction liquid；
(2) gel forming agent is prepared：The Acritamer 940 that concentration is 65 part 1.25% is added in 450 parts of purified water, fully
After swelling, 250 parts of glycerol, 3 parts of hydroxy methacrylates and 8 parts of polyoxyethylene sorbitan monoleates added, is stirred, is obtained gel forming agent；
(3) weight ratio according to Chinese medicine extract and gel forming agent is 1：5, by Chinese medicine extraction liquid be added to gel into
In type agent, stirring forms uniform, sticky gel, obtains Traditional Chinese medicine compound gel agent.
Embodiment 5
A kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, wherein：
Chinese medicine extract is prepared from by the crude drug for including following weight portion：38 parts of Flemingia macrophylla, 21 parts of Radix Angelicae Sinensis, Huang
3 parts of 14 parts of stilbene, 11 parts of Cacumen Platycladi, 9 parts of Fructus Gardeniae, 11 parts of Radix Sanguisorbae and Herba Menthae；
Gel forming agent includes that 55 parts of carbomer, 250 parts of glycerol, 4 parts of hydroxy methacrylate, polyoxyethylene sorbitan monoleate are by weight
7 parts and 550 parts of purified water；
The weight ratio of Chinese medicine extract and gel forming agent is 1：5.
The preparation method of the Traditional Chinese medicine compound gel agent of the present embodiment, comprises the following steps：
(1) Chinese medicine extract is prepared：Weigh 38 parts of Flemingia macrophyllas of crude drug, 21 portions of Radix Angelicae Sinensis, 14 portions of Radixs Astragali, 11 portions of Cacumen Platycladis
Leaf, 9 portions of Fructus Gardeniaes, 11 portions of Radix Sanguisorbaes and 3 parts of Herba Menthae mixing, add water to cook 3 times, and the weight for adding water is 8 times of the crude drug weight,
Decocting time is 2 hours every time, filters, merging filtrate, takes supernatant standing, is concentrated into relative density for (60 DEG C of 1.05-1.10
Measure), obtain Chinese medicine extraction liquid；
(2) gel forming agent is prepared：The Acritamer 940 that concentration is 55 part 1.25% is added in 550 parts of purified water, fully
After swelling, 250 parts of glycerol, 4 parts of hydroxy methacrylates and 7 parts of polyoxyethylene sorbitan monoleates added, is stirred, is obtained gel forming agent；
(3) weight ratio according to Chinese medicine extract and gel forming agent is 1：5, by Chinese medicine extraction liquid be added to gel into
In type agent, stirring forms uniform, sticky gel, obtains Traditional Chinese medicine compound gel agent.
The using method of Traditional Chinese medicine compound gel agent of the treatment wound of the present invention is：The agent of this Traditional Chinese medicine compound gel is external
Medicine, for exposure method and occlusive dressing are effective, is applied directly to hinder face, and severe one is smeared twice on the 1st, and the lighter smears on the 1st
Once or the next day once.
Effect example 1
In order to therapeutic effect of the present invention to burn and scald, clinical collection fire victim 120, male 68, women are described
52, age 5-60 year, light degree Ⅱ 73, depth II degree 47.
1. administrated method：The skin around burn and scald is cleaned out before smearing medicine, cover if any medicated clothing and gently should open
Or cut off, avoid as far as possible tearing, wipe and cause exfoliation；Pollution wound surface can use normal saline flushing, clear the pollution off in time or
Pile up the beancurd sheet for coming off；Larger vesicle sterilization shears low level breaks, and retains bleb skin after discharging water；After debridement, inhaled with aseptic cotton
Traditional Chinese medicine compound gel agent directly can be applied in using exposure method and hinder face by net wound surface moisture, and severe patient can adopt local to wrap
Prick therapy and Traditional Chinese medicine compound gel agent is applied to and hinder face, wrap up after being covered with gauze.120 patients are divided into 6 groups, wherein test group 1-
5 respectively using the Traditional Chinese medicine compound gel agent prepared in embodiment 1-5, and matched group is medicine for controlling burn and scald commercially available using other
Cream, light degree Ⅱ are smeared once daily, and the course for the treatment of is 7 days, deep II degree, smears daily twice, the course for the treatment of 15 days.
2. evaluation criterion：
It is that pain and redness disappear to fully recover, and without obvious cicatrix.
Effective is that pain and redness mitigate, and has slight cicatrix.
Invalid is that pain and redness are not cut down, and has obvious cicatrix.
Calculate total effective rate=(recovery from illness case+effective case)/total case
3. clinical effectiveness is shown in Table 1.
Clinical effectiveness of the 1 Traditional Chinese medicine compound gel agent of table to burn and scald
| Recovery from illness | Effective | Invalid | Total effective rate | |
| Test group 1 | 18 | 2 | 0 | 100% |
| Test group 2 | 15 | 4 | 1 | 95% |
| Test group 3 | 16 | 3 | 1 | 95% |
| Test group 4 | 17 | 3 | 0 | 100% |
| Test group 5 | 16 | 4 | 0 | 100% |
| Matched group | 6 | 9 | 5 | 75% |
From table 1 it follows that the Traditional Chinese medicine compound gel agent of the present invention can mitigate pain at short notice, eliminate red
Swollen, and more after preventing from scar, to the effective percentage of burned patient up to more than 95%, significantly larger than commercially available burn and scald of controlling
Ointment, alleviates the pain of patient, it is seen that the Traditional Chinese medicine compound gel agent of the present invention, and rationally, treating both the principal and secondary aspects of a disease, with heat clearing away solution for formula
Poison, cool the blood dissipate blood stasis, reducing swelling and alleviating pain, effect of hemostasia and promoting granulation, while make gel by Chinese medicine extract so that medicine dispersion effect
And good absorbing effect, good effect, short treating period.
Effect example 2
In order to therapeutic effect of the present invention to infectious trauma, clinical collection infectious trauma patient 150, male are described
86, women 64, age 5-70 year.
Severe patient, smears twice, compared with the lighter once a day, or once every other day for one day.
Cure 142, take a turn for the better 8, general wound can be fully recovered compared with the lighter for 5-7 days, severe patient, fully recover in 1 month.
Effect example 3
In order to therapeutic effect of the present invention to decubital ulcer, clinical collection infectious trauma patient 30, male 19, female are described
Property 11, age 45-80 year.
Smear within one day twice, cure 24 inner examples, take a turn for the better 6, cure time is most short 10 days, up to 3 months.
It is exemplified below the effect that several model cases further illustrate the present invention:
Model case 1
Zhang, man, 45 years old, coal miner, when colliery is gone into the well, hand is caused muscular tissue seriously to be damaged by machine pusher
Bad, arrive hospital surgery afterwards and go to a doctor, defeated 10 days antibacterial medicinal liquid kimonos medicine for external use, effect on driving birds is not good are hindered face congestion and swelling pain, have nigrescence
Slough, and portion of tissue infection, fester, have purulent secretion.
The Traditional Chinese medicine compound gel agent provided using embodiment 1, is smeared twice for one day, and after 3 days, pain disappears substantially, redness disappears
Move back, after 7 days, wound face surrounding skin is pale red by blacking, with the improvement of situation, is changed to once a day, then after the next day be changed to
Once, hand is fully recovered after one month, function is normal, without cicatrization.
Model case 2
What certain, female, 14 years old, student, as hot-water bottle is broken into pieces accidentally, right crus of diaphragm and right lower limb are scalding, sharp ache, right
Foot and right lower limb have an obvious blister, and skin is in bronzing, using the compound gel of other products after, there is swelling and burst in effect on driving birds is not good
Infectionss, suppurate rotten to the corn.
The Traditional Chinese medicine compound gel agent provided using embodiment 2, is smeared twice for one day, and pain relief after two hours, after 1 week
Injury goes pus to subside a swelling, and fully recovers, without cicatrization after 2 weeks.
Model case 3
Week certain, female, 32 years old, accounting, as pot catches fire, both hands serious burn, after hospitalize a couple of days, the defeated antibiosis of vein
Element, but unsatisfactory curative effect, both hands swelling, wound surface have stiff incrustation in black, infection suppurates under crust, hurt like hell.
The Traditional Chinese medicine compound gel agent provided using embodiment 3, is smeared twice for one day, and pain gradually mitigates, and incrustation softens simultaneously
Start shedding off, crust comes off after 2 days, expose the wound surface of a large amount of suppurations, after cleaning, continue the Traditional Chinese medicine compound gel for smearing the present invention
Agent, gradually grows new meat, fully recovers after 2 weeks, and skin is ruddy, without cicatrization.
Model case 4
Liu, man, 71 years old, due to body illness, long-term bed, causes buttocks ischemic necrosiss, curing ulcer erosion to have purulence
Secretions.
The Traditional Chinese medicine compound gel agent provided using embodiment 4, is smeared twice for one day, and pus and blood secretions are gradually decreased, after by
New meat is gradually grown, and after one month, wound surface is fully recovered, without obvious cicatrization.
Model case 5
Cui, female 43 years old, when doing farm work in the ground, are drawn to lower limb by colter accidentally, dealt with improperly at that time, causes leg to be felt
Dye is suppurated, and wound swelling is festered.
The Traditional Chinese medicine compound gel agent provided using embodiment 4, is smeared twice for one day, is smeared twice within one day, after 5 days, is removed pus
Detumescence, and new meat is grown, after 3 weeks, wound healing, skin is without obvious cicatrix.
Finally it should be noted that：Various embodiments above only in order to technical scheme to be described, rather than a limitation；To the greatest extent
Pipe has been described in detail to the present invention with reference to foregoing embodiments, it will be understood by those within the art that：Its according to
So the technical scheme described in foregoing embodiments can be modified, or which part or all technical characteristic are entered
Row equivalent；And these modifications or replacement, do not make the essence of appropriate technical solution depart from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of Traditional Chinese medicine compound gel agent for treating wound, including Chinese medicine extract and gel forming agent, it is characterised in that described
Chinese medicine extract is prepared from by the raw material of following weight portion：Flemingia macrophylla 30-50 parts, Radix Angelicae Sinensis 15-25 parts, Radix Astragali 10-20
Part, Cacumen Platycladi 5-15 parts, Fructus Gardeniae 5-15 parts, Radix Sanguisorbae 5-15 parts and Herba Menthae 2-6 parts.
2. Traditional Chinese medicine compound gel agent according to claim 1, it is characterised in that the Chinese medicine extract is by following weight portion
Raw material be prepared from：Flemingia macrophylla 35-45 parts, Radix Angelicae Sinensis 17-23 parts, Radix Astragali 12-18 parts, Cacumen Platycladi 8-12 parts, Fructus Gardeniae 8-
12 parts, Radix Sanguisorbae 8-12 parts and Herba Menthae 3-5 parts.
3. Traditional Chinese medicine compound gel agent according to claim 2, it is characterised in that the Chinese medicine extract is by following weight portion
Raw material be prepared from：40 parts of Flemingia macrophylla, 20 parts of Radix Angelicae Sinensis, 15 parts of the Radix Astragali, 10 parts of Cacumen Platycladi, 10 parts of Fructus Gardeniae, 10 parts of Radix Sanguisorbae
With 4 parts of Herba Menthae.
4. the Traditional Chinese medicine compound gel agent according to any one of claim 1-3, it is characterised in that the gel forming agent is pressed
Weight portion meter includes gel-type vehicle 50-80 parts, wetting agent 200-300 parts, preservative 2-4 parts, surfactant 5-10 parts and pure
Change water 400-600 parts.
5. Traditional Chinese medicine compound gel agent according to claim 4, it is characterised in that the gel-type vehicle is carbomer.
6. Traditional Chinese medicine compound gel agent according to claim 5, it is characterised in that the wetting agent be glycerol, the anti-corrosion
Agent is hydroxy methacrylate, and the surfactant is polyoxyethylene sorbitan monoleate.
7. Traditional Chinese medicine compound gel agent according to claim 4, it is characterised in that the Chinese medicine extract and gel forming agent
Weight ratio be 1：4-8.
8. a kind of preparation method of the Traditional Chinese medicine compound gel agent as any one of claim 1-7, it is characterised in that include
Following steps：
(1) Chinese medicine extract is prepared：Weigh Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi, Fructus Gardeniae, seven taste raw material of Radix Sanguisorbae and Herba Menthae
Medicine mixes, and takes decocting cooking method to be extracted, and is concentrated into relative density for 1.05-1.10 (60 DEG C measure), obtains Chinese medicine and carries
Take thing；
(2) gel forming agent is prepared：Gel-type vehicle is added in purified water, fully swelling after, add wetting agent, preservative and table
Face activating agent, obtains gel forming agent；
(3) Chinese medicine extraction liquid is added in gel forming agent, stirring forms uniform, sticky gel, obtains Chinese medicine compound and coagulate
Colloid.
9. according to the preparation method of the Traditional Chinese medicine compound gel agent described in claim 8, it is characterised in that comprise the following steps：
(1) Chinese medicine extract is prepared：Weigh Flemingia macrophylla, Radix Angelicae Sinensis, the Radix Astragali, Cacumen Platycladi, Fructus Gardeniae, seven taste raw material of Radix Sanguisorbae and Herba Menthae
Medicine mixes, and adds water to cook 2-3 time, and the weight for adding water is 7-9 times of the crude drug weight, and each decocting time is 2-3 hours,
Filter, merging filtrate, take supernatant standing, relative density is concentrated into for 1.05-1.10 (60 DEG C measure), obtains Chinese medicine extraction
Liquid；
(2) gel forming agent is prepared：Carbomer is added in purified water, fully swelling after, add glycerol, hydroxy methacrylate and poly- mountain
Pear ester 80, stirs, and obtains gel forming agent；
(3) Chinese medicine extraction liquid is added in gel forming agent, stirring forms uniform, sticky gel, obtains Chinese medicine compound and coagulate
Colloid.
10. the Traditional Chinese medicine compound gel agent as any one of claim 1-7 is in terms of burn and scald, infectious trauma and decubital ulcer
Application.
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| CN201611269639.5A CN106491769A (en) | 2016-12-31 | 2016-12-31 | The Traditional Chinese medicine compound gel agent for the treatment of wound, preparation method and applications |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107007682A (en) * | 2017-04-11 | 2017-08-04 | 杭州雀皇生物科技有限公司 | It is a kind of to treat herbal mixture gel of burn and scald and preparation method thereof |
| CN107007748A (en) * | 2017-05-24 | 2017-08-04 | 江苏宁康医疗器械有限公司 | Improve Chinese medicine composition, medicine of physically weak symptom and its preparation method and application |
| CN107837376A (en) * | 2017-11-17 | 2018-03-27 | 李谊 | A kind of hemostasis and pain-relieving gel and preparation method thereof |
| RU2681851C1 (en) * | 2018-05-04 | 2019-03-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) | Anti-burn means |
| CN115068554A (en) * | 2022-07-12 | 2022-09-20 | 新希望六和股份有限公司 | Antibiotic substitute and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007682A (en) * | 2017-04-11 | 2017-08-04 | 杭州雀皇生物科技有限公司 | It is a kind of to treat herbal mixture gel of burn and scald and preparation method thereof |
| CN107007748A (en) * | 2017-05-24 | 2017-08-04 | 江苏宁康医疗器械有限公司 | Improve Chinese medicine composition, medicine of physically weak symptom and its preparation method and application |
| CN107837376A (en) * | 2017-11-17 | 2018-03-27 | 李谊 | A kind of hemostasis and pain-relieving gel and preparation method thereof |
| RU2681851C1 (en) * | 2018-05-04 | 2019-03-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) | Anti-burn means |
| CN115068554A (en) * | 2022-07-12 | 2022-09-20 | 新希望六和股份有限公司 | Antibiotic substitute and preparation method thereof |
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