CN102451249B - Drug for treating burn and scald, and application thereof - Google Patents
Drug for treating burn and scald, and application thereof Download PDFInfo
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- CN102451249B CN102451249B CN 201010510481 CN201010510481A CN102451249B CN 102451249 B CN102451249 B CN 102451249B CN 201010510481 CN201010510481 CN 201010510481 CN 201010510481 A CN201010510481 A CN 201010510481A CN 102451249 B CN102451249 B CN 102451249B
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Abstract
The present invention provides a drug for treating burn and scald. The drug comprises a drug composition and/or a pharmaceutically-acceptable carrier, and is characterized in that: the drug composition mainly comprises the following raw material drugs, wherein the raw material drugs comprise, by weight, 10-20 parts of common melastoma herb, 15-25 parts of narrowleaf screwtree root, 10-25 parts of mallotus apelta, 10-20 parts of breynia fruticosa, 10-20 parts of parasite scurrula, 10-20 parts of rhapniolepisindica, and a proper amount of antibiotic. The application for the drug comprises that: according to the weight part ratio, the raw material drugs are dried in the sun and grinded, a debridement treatment is performed on a wound, then the wound is cleaned, the blister is pierced from the side surface by using a sterile needle to remove the water, the blister skin removal is not required, the grinded raw material drugs are externally coated on the wound position, and the dressing is not required, such that the disease condition is easily observed, and the pain on the patient during the dressing changing process is reduced. The drug is usually applied twice a day, and the effect can be provided after continuously using the drug for about a week.
Description
Technical field
The present patent application relates to a kind of pharmaceutical composition and application thereof for the treatment of scald, burn, and described pharmaceutical composition has the effect of promoting regeneration of the tissue and arresting bleeding, analgesic antiphlogistic and heat radiation convergence, belongs to the Chinese medicine technical field.
Background technology
Burn is that body directly contacts high temp objects or is subject to the variation that strong heat radiation occurs, and is the tissue injury that is caused by high temperature, chemical substance or electricity.The degree of burn is by the height of temperature, the length of action time and difference, and local variation can be divided into four degree: the first degree: because of angioparalysis hyperemia; The second degree: form the burn vesicle that is full of serum; The 3rd degree: tissue necrosis; Fourth: the carbonization of tissue.Lactic acid production during burn in visible blood increases, and the pH value of arteriovenous blood reduces, and blood capillary is handicapped to be increased the weight of along with organizing, and anoxemia (anoxemia) is also serious.The tissue of burn may be downright bad, and during the tissue burn, endovascular liquid oozes out and causes tissue edema, and during large-area burns, vascular permeability is abnormal, loses large quantity of fluid, may cause shock.
The order of severity of burn depends on scope and the degree of depth of wounded tissue, and depth of burn can be divided into I degree, II degree and III degree.I degree burn injury is the lightest, and burned skin is rubescent, pain, obviously touch a tender spot, have and ooze out or edema, and when gently pressing the injury, the part bleaches, but there is no vesicle; II degree burn injury is darker, skin blister, and vesicle bottom takes on a red color or white, has been full of liquid limpid, thickness, touches a tender spot responsive, bleaches during compressing; III degree burn injury is the darkest, burn surfaces can turn white, deliquescing or be black, carbonization hide-like, become pale owing to burning skin, often be mistaken as normal skin in the pale skin people, but no longer variable color during compressing, the erythrocyte of destruction can make the burn local skin be cerise, and vesicle is arranged once in a while, the hair in burn district is easy to extract, and feels to go down.III degree burnt area does not generally have the pain sensation, because the teleneuron of skin is destroyed, usually will through in a few days, could distinguish dark II degree and III degree burn after burn.
The have deep theoretical basis of the traditional Chinese medical science about burning, the traditional Chinese medical science think that burn also claims to burn skin ulcer, soup sprinkles baked wheaten cake, burn.Light shallow person does not affect viscera function usually, only blush occurs in the part, blisters, or rots; Severe one infringement area is large and dark, produces fire and contains impairment of YIN, and pyretic toxicity is very vehement, and consumption is hindered cloudy liquid in body.Very pyretic toxicity inside fire attack, or the General Symptoms such as QI and blood deficiency, clinical as seen thirsty, heating, constipation, even the dysuria agitation is not peaceful, unconsciousness and delirium.Treatment the lighter only needs external treatment, and with Radix Sanguisorbae, Radix Et Rhizoma Rhei equivalent, a little grinds into powder Borneolum Syntheticum, and Oleum sesami is transferred and applied.The suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of severe one, heat-clearing and toxic substances removing, Liang Ying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., or the solid and gas yin nourishing, recuperating depleted YANG and rescuing the patient from collapse, multiselect adds flavor with Rhizoma Coptidis toxic materials clearing away decoction, xijiao Dihuang Tang, Saigae Tataricae Ramulus Uncariae Cum Uncis soup or SHENGMAI SAN, shenfu decoction etc., if the course of disease is with the passing of time, the wasting QI-blood person should benefiting qi and nourishing blood, available eight delicacies Tonga flavor.Outer treating method comprises the skin ulcer face that cleans, and blister is processed, and removes the items such as eschar or skin-grafting, also can be with above-mentioned ointment coating skin ulcer face, and severe patient should in time carry out Chinese and western medicine and rescue.
Think all in the ancient Chinese medicine document that its cause of disease is pyretic toxicity, adopting in treatment is almost heat and toxic materials clearing away medicine entirely.Point out in the Tang Dynasty Sun Simiao " prescriptions worth thousand gold " that primary disease is many by due to the evil wound of burning hot poison, treatment is when converging to the master with bitter cold, meaning " burn is with Fructus Gardeniae, Radix Scutellariae, hold back and fry in shallow oil soup with the pouring skin ulcer in vain, gas slip the pyretic toxicity that reduces internal heat "." Elementary Medicine sore due to scald and burn " points out that " the soup bubble is burnt skin ulcer.Just appropriate to the occasion very reluctantly by force, suddenly warm oneself in front of a fire and process, carefully do not press it with cold thing, heat can not be gone out.Rotten people's muscles and bones.Rear with seven liang of Mirabilitum crystallinas, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Halloysitum Rubrum each one or two, very the person adds Borneolum Syntheticum a little is the end. wine is transferred or clear accent of duck applied.The old scholar's tongued bell of the Qing Dynasty points out that at " Qingnang Mijue " primary disease is due to fire-toxin, inside and outside be subjected to it, treatment when inside and outside rule together, meaning " soup scalds skin ulcer ... gently evil is at skin, and heavy do harm at muscle, more so the person is harmful at internal organs ... therefore control the disease of baked wheaten cake; must inside and outside rule together, the fire-toxin legibility is also ".Modern TCM document great majority think that burn is that domination of heat is hollow heart because of due to heat, so that skin rots, the inside fire attack possibility is arranged during outer poison, so think that heat extraction is outer also poisonous, its Etiologic Mechanism is still pyretic toxicity, Chinese medicine for external application or the square medicines that adopt heat-clearing and toxic substances removing in treatment more.
The small-area burn traumatic condition is lighter, can not infuse, and except attention control infects, focuses on handling well wound surface; The above burn of moderate traumatic condition is serious, must take into account constitutional treatment and wound surface and process.Wound surface is processed: wound surface is noted Protective isolation, and especially correct during large-area burns to process wound surface be the key of burn treating success or failure, and the processing of wound surface eschar is key link.Rule: an I ° burn wound keeps clean, and shallow II ° wound surface should be protected from infection, and dark II ° of wound surface will protect residual epithelium to reduce cicatrix, and III ° of wound surface protected from infection, the planned crust of cutting.The initial stage wound surface is processed, and also claims the burn debridement, and purpose is to remove wound surface to pollute as far as possible, the scrub healthy skin.Namely repeatedly rinse wound surface and surrounding skin with a large amount of sterile saline, and take out stains or foreign body, vesicle ulceration should remove the bleb skin, eschar is coated with iodine tincture, the externally used antimicrobial agent is effective to the prevention traumatic infection, and after debridement, II ° of wound surface multiselect is coated with silver sulfadiazine or moistening burn.
Chinese medicine and preparation for treating burn and scald thereof, pharmacology and clinical trial proof have good curative effect.Different according to compound method and using method, the Chinese medicine that is used for burn is broadly divided into the dosage forms such as unguentum, powder, decoction or water preparation, oil preparation, tincture, cream, Emulsion, liniment, membrane.These preparation great majority all have the effects such as heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, regulating QI to relieve pain, expelling the stasis for the new.
The applicant is according to forefathers' summary of experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, obtain a kind of pharmaceutical composition with good therapeutic effect, the below describes the primary raw material medicine of this compositions, so that the public better understands:
Herba Melastomatis Candii, nature and flavor acid, puckery, cool in nature; Return spleen, stomach, lung, Liver Channel.Effect with removing food stagnancy dampness removing, promoting blood circulation and hemostasis, heat-clearing and toxic substances removing.Cure mainly food stagnation, let out dysentery, hepatitis, treating swelling and pain by traumatic injury, traumatic hemorrhage, epistaxis, hemoptysis, spit blood, have blood in stool, under menorrhagia, metrorrhagia, puerperal abdonimal pain, leucorrhea, milk ring, swollen, the venom of blood examination vasculitis, acute appendicitis, skin ulcer.
Radix Helicteris, nature and flavor are bitter, little sweet, and are cold.Slightly poisonous.Has heat-clearing and toxic substances removing, the effect of cough-relieving.Be used for cold and high fever, tonsillitis, pharyngolaryngitis, parotitis, measles, cough, malaria; Venom is controlled in external, traumatic hemorrhage, hemorrhoid, carbuncle furuncle.
Folium Malloti Apeltae has another name called wild paulownia, Ye Xiabai, white back of the body wood, carries on the back ma, Bai Piaoshu, white crown in vain, and property mildly bitter flavor, puckery is flat.Function cures mainly: root: easing the affected liver is invigorated blood circulation, invigorating the spleen for eliminating dampness, and convergence is taken off admittedly.Be used for chronic hepatitis, hepatosplenomegaly, uterine prolapse, proctoptosis, leucorrhea, edema during pregnancy.Leaf: anti-inflammation hemostasia.Otitis media is controlled in external, furuncle and phyma, traumatic injury, traumatic hemorrhage.
The Fruticose Breyniae Leaf and Twig, another name Folium et cacumen Breyniae Fruticosae, deity supposed to be a chaser of demons's grass, Canis familiaris L. foot thorn, GUIHUAFU.Carry in " south of the Five Ridges gather medicinal herbs record ": sweet in the mouth, cold in nature, rotten meat is washed in loose skin ulcer sterilization, controls dermatitis rhus, its leaf, the people meets poison food, feels fragrant and sweet, separates the cattle disease pyretic toxicity, its root soaks good wine, all latex dusts not bitterly and breast less, mash its leaf, and distiller grains Mel takes it.
Herba Taxilli is the stem and branch with leaf of Loranthaceae evergreen dwarf shrub plant Herba Taxilli or Herba Visci, has another name called the parasitic Holy Benevolent Prescriptions of peach tree, Ramulus et Folium Loranthi Chinensis " it is former that book on Chinese herbal medicine is asked ", wide parasitic " Chinese medicinal herbal ".Wind-damp dispelling is arranged, liver and kidney tonifying, bone and muscle strengthening, antiabortive effect." herbal classic is met former ": the residual air of parasitic Mulberry and giving birth to, property is specially dispeled the wind by wet, logical blood circulation regulating, therefore " herbal classic " got and controlled married woman's lumbago, the diseases such as children's's stiffback, Xuemaitong accent and the skin eyebrow must all be subjected to its shade namely has carbuncle, also must dissipate.
Raphiolepis indica has another name called and cuts a hole the angle, spring flower, and wood in ferrum belongs to Rosaceae.Be distributed in Yangtze River in China downstream to southern each province, be born in broad-leaf forest or sparse woods more.Root is used as medicine, and can adopt the whole year.Cure mainly ankle joint old trauma and have a pain, traumatic injury.
Summary of the invention
The present patent application merges the drug effect of Western medicine absorbing on the basis of using for reference traditional medicine, provides a kind of certificate that the medicine of good treatment burn, scald effect is arranged.
Specifically, treatment of the present invention burn, the medicine of scalding, by pharmaceutical composition and/or pharmaceutically the acceptable carrier form, it is characterized in that, described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 10-20 part, Radix Helicteris: 15-25 part, Folium Malloti Apeltae: 10-25 part;
Fruticose Breyniae Leaf and Twig: 10-20 part, Herba Taxilli: 10-20 part, Raphiolepis indica: 10-20 part.
Treatment burn of the present invention, the medicine of scalding is characterized in that the various crude drug of the preferred following weight portion of described pharmaceutical composition:
Herba Melastomatis Candii: 15 parts, Radix Helicteris: 20 parts, Folium Malloti Apeltae: 20 parts;
The Fruticose Breyniae Leaf and Twig: 15 parts, Herba Taxilli: 15 parts, Raphiolepis indica: 15 parts.
Treatment burn of the present invention, the medicine of scalding is characterized in that described pharmaceutical composition also comprises the antibiotic of 1-3 part.
Treatment burn of the present invention, the medicine of scalding is characterized in that described antibiotic comprises furazolidone.
Treatment burn of the present invention, the application of medicine in preparation treatment burn, scald medicament of scalding.
Treatment burn of the present invention, the medicine of scalding in use, first dry various crude drug, after wearing into fine powder, then according to above-mentioned formula, obtain described pharmaceutical composition, then pharmaceutical composition are spread on the affected part outward.
When treatment, note the following aspects:
1, the initial stage wound surface is processed, and also claims burn, scalds debridement, and purpose is to remove wound surface to pollute as far as possible, the scrub healthy skin;
2, first repeatedly rinse wound surface and surrounding skin with a large amount of sterile saline, and take out stains or foreign body, need not to remove the bleb skin;
3 and then the powder of the described pharmaceutical composition of external application, generally do not advise wrapping, be convenient to observe the state of an illness, reduce the misery of bringing to the patient when changing dressings, keep the opening of wound surface, protect from infection;
4, the general described medicated powder of external application every day is 1-2 time, when serious, when transudate is many, can increase in right amount the consumption of medicated powder, takes effect about a general week, and dead bark comes off, preventing from scar.
The specific embodiment
Below in conjunction with concrete embodiment, the described pharmaceutical composition of the present patent application is carried out concrete description; purpose is better to understand technology contents of the present invention for the public; rather than to the restriction of the described technology contents of the present patent application; in fact, any increase and decrease, replacement and the improvement of doing in not violating spirit of the present invention is all within the present patent application technical scheme required for protection.
Embodiment one
Treatment of the present invention burn, the medicine of scalding, by pharmaceutical composition and/or pharmaceutically the acceptable carrier form, it is characterized in that, described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 10 parts, Radix Helicteris: 15 parts, Folium Malloti Apeltae: 10 parts;
The Fruticose Breyniae Leaf and Twig: 10 parts, Herba Taxilli: 10 parts, Raphiolepis indica: 10 parts.
The above-mentioned raw materials medicine dried grind, by above-mentioned weight portion formula, then with wound through debridement treatment, clean wound, pierce through from the blister side with the syringe needle after sterilization, water is emitted, need not to remove the bleb skin, external application is to the affected part, need not wrapping, be convenient to observe the state of an illness, reduce the misery of bringing to the patient when changing dressings, general one day twice, use continuously and can take effect in 4-6 days.
Embodiment two
Treatment burn of the present invention, the medicine of scalding, described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 20 parts, Radix Helicteris: 25 parts, Folium Malloti Apeltae: 25 parts;
The Fruticose Breyniae Leaf and Twig: 20 parts, Herba Taxilli: 20 parts, Raphiolepis indica: 20 parts, 2 parts of furazolidones.
The above-mentioned raw materials medicine dried grind, by above-mentioned weight portion formula, then with wound through debridement treatment, clean wound, pierce through from the blister side with the syringe needle after sterilization, water is emitted, need not to remove the bleb skin, external application is to the affected part, need not wrapping, be convenient to observe the state of an illness, reduce the misery of bringing to the patient when changing dressings, general one day twice, use continuously and can take effect in 4-6 days.
Embodiment three
Treatment burn of the present invention, the medicine of scalding, the various crude drug of the preferred following weight portion of described pharmaceutical composition:
Herba Melastomatis Candii: 15 parts, Radix Helicteris: 20 parts, Folium Malloti Apeltae: 20 parts;
The Fruticose Breyniae Leaf and Twig: 15 parts, Herba Taxilli: 15 parts, Raphiolepis indica: 15 parts, furazolidone: 3 parts.
The above-mentioned raw materials medicine dried grind, by above-mentioned weight portion formula, then with wound through debridement treatment, clean wound, pierce through from the blister side with the syringe needle after sterilization, water is emitted, need not to remove the bleb skin, external application is to the affected part, need not wrapping, be convenient to observe the state of an illness, reduce the misery of bringing to the patient when changing dressings, general one day twice, use continuously and can take effect in 4-6 days.
Below in conjunction with the case of curing in applicant's medical practice for many years, further illustrate function and the curative effect of the described treatment burn of the application, scald medicament:
Case one
The Wang, the man, 40 years old, kerosene was scalded Head And Face, and bubble in the affected part, decortication, and part is bled, and 15 parts of Herba Melastomatis Candiis, 20 parts of Radix Helicteriss, 20 parts of Folium Malloti Apeltaes, 15 parts of Fruticose Breyniae Leaf and Twigs, 15 parts of Herba Taxillis, 15 parts of Raphiolepis indicas are adopted in second degree burn, separately add 3 parts of furazolidones.The said medicine composition is dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, applies medicated powder and gets final product, and one day twice, continuous 4 days, dead bark came off, preventing from scar.
Case two
Lee, the man, 2 years old, boiled water was scalded below waist, and bubble in the affected part, decortication, and transudate is more, and 20 parts of Herba Melastomatis Candiis, 25 parts of Radix Helicteriss, 25 parts of Folium Malloti Apeltaes, 20 parts of Fruticose Breyniae Leaf and Twigs, 20 parts of Herba Taxillis, 20 parts of Raphiolepis indicas are adopted in second degree burn, add 1 part of furazolidone.The said medicine composition is dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, applies medicated powder and gets final product, and one day twice, continuous 4 days, dead bark came off, preventing from scar.
Case three
Zhang, the female, 40 years old, more than chest is scalded in the ejection of pressure cooker gruel, bubble in the affected part, decortication, second degree burn, and transudate is more, invalid after 2 weeks of hospitalize, adopt 10 parts of Herba Melastomatis Candiis, 15 parts of Radix Helicteriss, 10 parts of Folium Malloti Apeltaes, 10 parts of Fruticose Breyniae Leaf and Twigs, 10 parts of Herba Taxillis, 10 parts of Raphiolepis indicas, add 2 parts of furazolidones.The said medicine composition is dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, and apply medicated powder and get final product, one day twice, continuous 4 days, wound healing, dead bark comes off, preventing from scar.
Case four
The literary composition certain, the man, 36 years old, the scalds of motorcycle exhaust pipe shank, bubble in the affected part, decortication, transudate is more, second degree burn, affected part area 10 * 15CM is invalid after 2 weeks of hospitalize, adopt 15 parts of Herba Melastomatis Candiis, 15 parts of Radix Helicteriss, 18 parts of Folium Malloti Apeltaes, 15 parts of Fruticose Breyniae Leaf and Twigs, 15 parts of Herba Taxillis, 15 parts of Raphiolepis indicas, add 3 parts of furazolidones.The said medicine composition is dried grind, and through treatment of wounds, clean wound need not except the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, and apply medicated powder and get final product, one day twice, continuous 5 days, wound healing, dead bark comes off, preventing from scar.
Case five
The field, the female 50 years old, suffers from diabetes for many years, after burn, bubble, peel in the affected part, and transudate is more, second degree burn, invalid after hospitalize, adopt 15 parts of Herba Melastomatis Candiis, 20 parts of Radix Helicteriss, 20 parts of Folium Malloti Apeltaes, 15 parts of Fruticose Breyniae Leaf and Twigs, 15 parts of Herba Taxillis, 15 parts of Raphiolepis indicas, add 2 parts of furazolidones.The said medicine composition is dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, and apply medicated powder and get final product, one day twice, continuous 5 days, wound healing, dead bark comes off, preventing from scar.
In fact, in the applicant's medical practice of nearly ten years, the case number of healing is numerous, all obtains good effect, and with low cost, alleviates the burden of sufferer.
The described treatment burn of the present patent application, the medicine of scalding, cost is low, and is evident in efficacy, and preventing from scar after curing has broad application prospects.
Claims (5)
1. medicine for the treatment of burn, scalding, by pharmaceutical composition and/or pharmaceutically the acceptable carrier form, it is characterized in that, described pharmaceutical composition comprises the various crude drug of following weight portion: Herba Melastomatis Candii: 10-20 part, Radix Helicteris: 15-25 part, Folium Malloti Apeltae: 10-25 part; Fruticose Breyniae Leaf and Twig: 10-20 part, Herba Taxilli: 10-20 part, Raphiolepis indica: 10-20 part.
2. described treatment burn, the medicine of scalding according to claim 1 is characterized in that the various crude drug of the preferred following weight portion of described pharmaceutical composition: Herba Melastomatis Candii: 15 parts, and Radix Helicteris: 20 parts, Folium Malloti Apeltae: 20 parts; The Fruticose Breyniae Leaf and Twig: 15 parts, Herba Taxilli: 15 parts, Raphiolepis indica: 15 parts.
3. described treatment burn, the medicine of scalding according to claim 1, is characterized in that, described pharmaceutical composition has also added the antibiotic of 1-3 part.
4. described treatment burn, the medicine of scalding according to claim 3, is characterized in that, described antibiotic is furazolidone.
5. the application of medicine in preparation treatment burn, scald medicament of the described treatment burn of claim 1 or 3, scald.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010510481 CN102451249B (en) | 2010-10-18 | 2010-10-18 | Drug for treating burn and scald, and application thereof |
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| CN 201010510481 CN102451249B (en) | 2010-10-18 | 2010-10-18 | Drug for treating burn and scald, and application thereof |
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| CN102451249A CN102451249A (en) | 2012-05-16 |
| CN102451249B true CN102451249B (en) | 2013-06-26 |
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| CN 201010510481 Expired - Fee Related CN102451249B (en) | 2010-10-18 | 2010-10-18 | Drug for treating burn and scald, and application thereof |
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| CN103845619A (en) * | 2014-02-28 | 2014-06-11 | 姚兴玲 | Traditional Chinese medicinal preparation for treating burn |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1214261A (en) * | 1998-10-21 | 1999-04-21 | 余际康 | Oral medicine for curing dermatosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1214261A (en) * | 1998-10-21 | 1999-04-21 | 余际康 | Oral medicine for curing dermatosis |
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