CN102451249A - Drug for treating burn and scald, and application thereof - Google Patents
Drug for treating burn and scald, and application thereof Download PDFInfo
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- CN102451249A CN102451249A CN2010105104812A CN201010510481A CN102451249A CN 102451249 A CN102451249 A CN 102451249A CN 2010105104812 A CN2010105104812 A CN 2010105104812A CN 201010510481 A CN201010510481 A CN 201010510481A CN 102451249 A CN102451249 A CN 102451249A
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Abstract
The present invention provides a drug for treating burn and scald. The drug comprises a drug composition and/or a pharmaceutically-acceptable carrier, and is characterized in that: the drug composition mainly comprises the following raw material drugs, wherein the raw material drugs comprise, by weight, 10-20 parts of common melastoma herb, 15-25 parts of narrowleaf screwtree root, 10-25 parts of mallotus apelta, 10-20 parts of breynia fruticosa, 10-20 parts of parasite scurrula, 10-20 parts of rhapniolepisindica, and a proper amount of antibiotic. The application for the drug comprises that: according to the weight part ratio, the raw material drugs are dried in the sun and grinded, a debridement treatment is performed on a wound, then the wound is cleaned, the blister is pierced from the side surface by using a sterile needle to remove the water, the blister skin removal is not required, the grinded raw material drugs are externally coated on the wound position, and the dressing is not required, such that the disease condition is easily observed, and the pain on the patient during the dressing changing process is reduced. The drug is usually applied twice a day, and the effect can be provided after continuously using the drug for about a week.
Description
Technical field
Application of the present invention relates to a kind of pharmaceutical composition and application thereof of treating scald, burn, and described pharmaceutical composition has promoting regeneration of the tissue and arresting bleeding, analgesic antiphlogistic and the effect of heat radiation astringent, belongs to the Chinese medicine technical field.
Background technology
Burn is that body directly contacts high temp objects or receives the strong variation that heat radiation took place, and is the tissue injury that is caused by high temperature, chemical substance or electricity.The degree of burn is by the height of temperature, the length of action time and difference, and partial variation can be divided into four degree: first degree: because of angioparalysis hyperemia; Second degree: form the burn vesicle that is full of serum; The 3rd degree: tissue necrosis; Fourth: the carbonization of tissue.Lactic acid production during burn in the visible blood increases, and the pH value of arteriovenous blood reduces, and blood capillary is handicapped to be increased the weight of along with organizing, and anoxemia (anoxemia) is also serious.The tissue of burn maybe be downright bad, and during the tissue burn, endovascular liquid oozes out and causes tissue edema, and during large-area burns, vascular permeability is unusual, loses big quantity of fluid, possibly cause shock.
The order of severity of burn depends on the scope and the degree of depth of wounded tissue, and depth of burn can be divided into I degree, II degree and III degree.I degree burn injury is the lightest, and burned skin is rubescent, pain, obviously touch a tender spot, have and ooze out or edema, and the part bleaches when gently pressing the injury, but does not have vesicle; II degree burn injury is darker, skin blister, and the vesicle bottom takes on a red color or white, has been full of limpid, heavy-gravity liquid, and it is responsive to touch a tender spot, and bleaches during compressing; III degree burn injury is the darkest, and burn surfaces can turn white, deliquescing or black in color, carbonization hide-like, is become pale owing to burn skin; Often be mistaken as normal skin at the pale skin philtrum; But no longer variable color during compressing, destructive erythrocyte can make the burn local skin be cerise, and vesicle is arranged once in a while; The hair in burn district is easy to extract, and feels to go down.III degree burn area does not generally have the pain sensation, because the teleneuron of skin is destroyed, usually will could distinguish dark II degree and III degree burn through in a few days behind the burn.
The have deep theoretical foundation of the traditional Chinese medical science about burning, the traditional Chinese medical science think that burn also claims to burn skin ulcer, soup sprinkles baked wheaten cake, burn.Light shallow person does not influence viscera function usually, only blush occurs in the part, blisters, or rots; It is big and dark that weight person damages area, produces fire and contain impairment of YIN, and pyretic toxicity is very vehement, and consumption is hindered cloudy liquid in the body.Very then pyretic toxicity inside fire attack, or General Symptoms such as QI and blood deficiency, clinical visible thirsty, heating, constipation, even the dysuria agitation is not peaceful, unconsciousness and delirium.Treatment the lighter only needs external treatment, and with Radix Sanguisorbae, Radix Et Rhizoma Rhei equivalent, a little grinds into powder Borneolum Syntheticum, and Oleum sesami is transferred and applied.The suitable determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of weight person, heat-clearing and toxic substances removing, Liang Ying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., or the solid and gas yin nourishing; Recuperating depleted YANG and rescuing the patient from collapse, multiselect adds flavor with Rhizoma Coptidis toxic materials clearing away decoction, xijiao Dihuang Tang, Saigae Tataricae Ramulus Uncariae Cum Uncis soup or SHENGMAI SAN, shenfu decoction etc., if the course of disease is with the passing of time; The wasting QI-blood person, then suitable benefiting qi and nourishing blood, available eight delicacies Tonga flavor.Outer treating method comprises the skin ulcer face that cleans, and blister is handled, and removes items such as eschar or skin-grafting, also can above-mentioned ointment be applied the skin ulcer face, and severe patient should in time carry out Chinese and western medicine and rescue.
Think all in the ancient Chinese medicine document that its cause of disease is a pyretic toxicity, in treatment, adopting almost is heat and toxic materials clearing away medicine entirely.Point out in the Tang Dynasty Sun Simiao " prescriptions worth thousand gold " that primary disease is many by due to the evil wound of burning hot poison, treatment is when converging to the master with bitter cold, meaning " burn with Fructus Gardeniae, Radix Scutellariae, in vain hold back fry in shallow oil soup to drench skin ulcer, gas slide reducing internal heat pyretic toxicity "." Elementary Medicine sore due to scald and burn " points out that " the soup bubble is burnt skin ulcer.Just appropriate to the occasion very reluctantly by force, suddenly warm oneself in front of a fire and process, carefully do not press it with cold thing, heat can not be gone out.Mashed people's muscles and bones.The back is with seven liang of Mirabilitum crystallinas, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Halloysitum Rubrum each one or two, very the person adds Borneolum Syntheticum a little is the end. wine transfer or duck clear transfer deposited.The old scholar's tongued bell of the Qing Dynasty points out that in " cave heaven difficult to understand purport " primary disease is due to the fire-toxin, inside and outside receive it, treatment when inside and outside rule together; Meaning " soup scalds skin ulcer ... gently then evil is at skin, and heavy then evil is at muscle, and more so the person is harmful at internal organs ... the disease of baked wheaten cake is controlled in event; must inside and outside rule together, then the fire-toxin legibility is also ".Modern TCM document great majority think that burn is that domination of heat is hollow heart then because of due to the heat, so that skin rots; The inside fire attack possibility is arranged when malicious outward; So think that heat extraction is outer also poisonous, its cause of disease mechanism is still pyretic toxicity, Chinese medicine for external application or the square medicines that adopt heat-clearing and toxic substances removing in the treatment more.
The small-area burn traumatic condition is lighter, can not infuse, and except that attention control infects, focuses on handling well wound surface; The above burn of moderate traumatic condition is serious, must take into account constitutional treatment and wound surface and handle.Wound surface is handled: wound surface notices that protectiveness isolates, and especially the correct handling wound surface is the burn treating key of success during large-area burns, and the processing of wound surface eschar is a key link.Rule: an I ° burn wound keeps clean, and shallow II ° wound surface should be protected from infection, and dark II ° of wound surface will protect residual epithelium to reduce cicatrix, and III ° of wound surface protected from infection, the planned crust of cutting.The initial stage wound surface is handled, and also claims the burn debridement, and purpose is to remove wound surface to pollute the scrub healthy skin as far as possible.Promptly wash wound surface and surrounding skin repeatedly with a large amount of sterile saline; And take out stains or foreign body, vesicle ulceration then should remove the bleb skin, eschar is coated with iodine tincture; The externally used antimicrobial agent is effective to the prevention traumatic infection, and II ° of wound surface multiselect is coated with silver sulfadiazine or moistening burn after the debridement.
Chinese medicine and preparation for treating burn and scald thereof, pharmacology and clinical trial proof have better curative effect.Different according to compound method and method for using, the Chinese medicine that is used to burn is broadly divided into dosage forms such as unguentum, powder, decoction or water preparation, oil preparation, tincture, cream, Emulsion, liniment, membrane.These preparation great majority all have effects such as heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, regulating QI to relieve pain, expelling the stasis for the new.
The applicant is according to forefathers' summary of experience and oneself medical practice for many years; Through research, and combine dialectical demonstration, obtain a kind of pharmaceutical composition with good therapeutic effect to Chinese medicine; Primary raw material medicine in the face of this compositions describes down, so that the public better understands:
Herba Melastomatis Candii, nature and flavor acid, puckery, cool in nature; Return spleen, stomach, lung, Liver Channel.Effect with removing food stagnancy dampness removing, promoting blood circulation and hemostasis, heat-clearing and toxic substances removing.Cure mainly food stagnation, let out dysentery, hepatitis, treating swelling and pain by traumatic injury, traumatic hemorrhage, epistaxis, hemoptysis, spit blood, have blood in stool, under the menorrhagia, metrorrhagia, puerperal abdonimal pain, leucorrhea, milk ring, blood examination property vasculitis, acute appendicitis, swollen, the venom of skin ulcer.
Radix Helicteris, nature and flavor are bitter, little sweet, and are cold.Slightly poisonous.Has heat-clearing and toxic substances removing, the effect of cough-relieving.Be used for cold and high fever, tonsillitis, pharyngolaryngitis, parotitis, measles, cough, malaria; Venom is controlled in external, traumatic hemorrhage, hemorrhoid, carbuncle furuncle.
Folium Malloti Apeltae has another name called wild paulownia, Ye Xiabai, white back of the body wood, carries on the back ma, Bai Piaoshu, white crown in vain, and property mildly bitter flavor, puckery is flat.Function cures mainly: root: easing the affected liver is invigorated blood circulation, invigorating the spleen for eliminating dampness, and convergence is taken off admittedly.Be used for chronic hepatitis, hepatosplenomegaly, uterine prolapse, proctoptosis, leucorrhea, edema during pregnancy.Leaf: anti-inflammation hemostasia.Otitis media is controlled in external, furuncle and phyma, traumatic injury, traumatic hemorrhage.
The Fruticose Breyniae Leaf and Twig, another name Folium et cacumen Breyniae Fruticosae, deity supposed to be a chaser of demons's grass, Canis familiaris L. foot thorn, GUIHUAFU.Carry in " south of the Five Ridges gather medicinal herbs record ": sweet in the mouth, and cold in nature, mashed meat is washed in the skin ulcer of loosing sterilization, controls dermatitis rhus, its leaf, the people meets poison food, then feels fragrant and sweet, separates the cattle disease pyretic toxicity, and its root soaks good wine, and all latex dusts not bitterly and breast lacks are not mashed its leaf and distiller grains Mel clothes.
Herba Taxilli is the stem and branch with leaf of Loranthaceae evergreen undershrub plant Herba Taxilli or Herba Visci, has another name called the parasitic Holy Benevolent Prescriptions of peach tree, Ramulus et Folium Loranthi Chinensis " it is former that book on Chinese herbal medicine is asked ", wide parasitic " Chinese medicinal herbal ".Wind-damp dispelling is arranged, liver and kidney tonifying, bone and muscle strengthening, antiabortive effect." herbal classic is met former ": the residual air of parasitic Mulberry and giving birth to, property is specially dispeled the wind by wet, logical blood circulation regulating, " so herbal classic " got and controlled married woman's lumbago, diseases such as children's's stiffback, blood vessels lead to accent and the skin eyebrow must all receive its shade, and carbuncle is promptly arranged, and also must dissipate.
Raphiolepis indica has another name called the cutter angle, spring flower, and wood in the ferrum belongs to Rosaceae.Be distributed in Chinese THE LOWER YANGTZE VALLEY to southern each province, be born in broad-leaf forest or the sparse woods more.Root is used as medicine, and can adopt the whole year.Cure mainly ankle joint old trauma and have a pain traumatic injury.
Summary of the invention
Application of the present invention is merged the drug effect of Western medicine absorbing on the basis of using for reference traditional medicine, provides a kind of certificate that the medicine of good treatment burn, scald effect is arranged.
Specifically, treatment of the present invention burn, the medicine of scalding, by pharmaceutical composition and/or pharmaceutically the acceptable carrier form, it is characterized in that described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 10-20 part, Radix Helicteris: 15-25 part, Folium Malloti Apeltae: 10-25 part;
Fruticose Breyniae Leaf and Twig: 10-20 part, Herba Taxilli: 10-20 part, Raphiolepis indica: 10-20 part.
Treatment burn of the present invention, the medicine of scalding is characterized in that the various crude drug of the preferred following weight portion of described pharmaceutical composition:
Herba Melastomatis Candii: 15 parts, Radix Helicteris: 20 parts, Folium Malloti Apeltae: 20 parts;
The Fruticose Breyniae Leaf and Twig: 15 parts, Herba Taxilli: 15 parts, Raphiolepis indica: 15 parts.
Treatment burn of the present invention, the medicine of scalding is characterized in that described pharmaceutical composition also comprises the antibiotic of 1-3 part.
Treatment burn of the present invention, the medicine of scalding is characterized in that described antibiotic comprises furazolidone.
Treatment burn of the present invention, the application of medicine in preparation treatment burn, scald medicament of scalding.
Treatment of the present invention burn, the medicine of scalding in use, dry various crude drug earlier, wear into fine powder after, again according to above-mentioned prescription, obtain described pharmaceutical composition, then pharmaceutical composition is spread on the affected part outward.
When treatment, note the following aspects:
1, the initial stage wound surface is handled, and also claims burn, scalds debridement, and purpose is to remove wound surface to pollute the scrub healthy skin as far as possible;
2, wash wound surface and surrounding skin repeatedly with a large amount of sterile saline earlier, and take out stains or foreign body, need not to remove the bleb skin;
3 and then the powder of the said pharmaceutical composition of external application, generally do not advise wrapping, be convenient to observe the state of an illness, reduce the misery of bringing to the patient when changing dressings, keep the opening of wound surface, protect from infection;
4, the general said medicated powder of external application every day is 1-2 time, when serious, when transudate is many, can increase the consumption of medicated powder in right amount, takes effect about a general week, and dead bark comes off, preventing from scar.
The specific embodiment
Below in conjunction with concrete embodiment the described pharmaceutical composition of application of the present invention is carried out concrete description; Purpose is better to understand technology contents of the present invention for the public; Rather than to the restriction of the said technology contents of application of the present invention; In fact, any increase and decrease, replacement and the improvement of in not violating spirit of the present invention, being done is all within application of the present invention technical scheme required for protection.
Embodiment one
Treatment of the present invention burn, the medicine of scalding, by pharmaceutical composition and/or pharmaceutically the acceptable carrier form, it is characterized in that described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 10 parts, Radix Helicteris: 15 parts, Folium Malloti Apeltae: 10 parts;
The Fruticose Breyniae Leaf and Twig: 10 parts, Herba Taxilli: 10 parts, Raphiolepis indica: 10 parts.
The above-mentioned raw materials medicine dried grind, by above-mentioned weight portion prescription, then with wound through debridement treatment, clean wound; Syringe needle with after the sterilization pierces through from the blister side, and water is emitted, and need not to remove the bleb skin; External application need not wrapping to the affected part, is convenient to observe the state of an illness; Reduce the misery of bringing to the patient when changing dressings, general one day twice, use continuously and can take effect in 4-6 days.
Embodiment two
Treatment burn of the present invention, the medicine of scalding, described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 20 parts, Radix Helicteris: 25 parts, Folium Malloti Apeltae: 25 parts;
The Fruticose Breyniae Leaf and Twig: 20 parts, Herba Taxilli: 20 parts, Raphiolepis indica: 20 parts, 2 parts of furazolidones.
The above-mentioned raw materials medicine dried grind, by above-mentioned weight portion prescription, then with wound through debridement treatment, clean wound; Syringe needle with after the sterilization pierces through from the blister side, and water is emitted, and need not to remove the bleb skin; External application need not wrapping to the affected part, is convenient to observe the state of an illness; Reduce the misery of bringing to the patient when changing dressings, general one day twice, use continuously and can take effect in 4-6 days.
Embodiment three
Treatment burn of the present invention, the medicine of scalding, the various crude drug of the preferred following weight portion of described pharmaceutical composition:
Herba Melastomatis Candii: 15 parts, Radix Helicteris: 20 parts, Folium Malloti Apeltae: 20 parts;
The Fruticose Breyniae Leaf and Twig: 15 parts, Herba Taxilli: 15 parts, Raphiolepis indica: 15 parts, furazolidone: 3 parts.
The above-mentioned raw materials medicine dried grind, by above-mentioned weight portion prescription, then with wound through debridement treatment, clean wound; Syringe needle with after the sterilization pierces through from the blister side, and water is emitted, and need not to remove the bleb skin; External application need not wrapping to the affected part, is convenient to observe the state of an illness; Reduce the misery of bringing to the patient when changing dressings, general one day twice, use continuously and can take effect in 4-6 days.
Below in conjunction with the case of curing in applicant's medical practice for many years, further specify the function and the curative effect of the said treatment burn of the application, scald medicament:
Case one
The Wang, the man, 40 years old, kerosene was scalded women's head-ornaments portion, and bubble in the affected part, decortication, and part is bled, and 15 parts of Herba Melastomatis Candiis, 20 parts of Radix Helicteriss, 20 parts of Folium Malloti Apeltaes, 15 parts of Fruticose Breyniae Leaf and Twigs, 15 parts of Herba Taxillis, 15 parts of Raphiolepis indicas are adopted in second degree burn, and other adds 3 parts of furazolidones.The said medicine composition dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, applies medicated powder and gets final product, and one day twice, continuous 4 days, dead bark came off, preventing from scar.
Case two
Lee, the man, 2 years old, boiled water was scalded below the waist, and bubble in the affected part, decortication, and transudate is more, and 20 parts of Herba Melastomatis Candiis, 25 parts of Radix Helicteriss, 25 parts of Folium Malloti Apeltaes, 20 parts of Fruticose Breyniae Leaf and Twigs, 20 parts of Herba Taxillis, 20 parts of Raphiolepis indicas are adopted in second degree burn, add 1 part of furazolidone.The said medicine composition dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, applies medicated powder and gets final product, and one day twice, continuous 4 days, dead bark came off, preventing from scar.
Case three
Zhang, woman, 40 years old; The ejection of pressure cooker gruel is scalded more than the chest; Bubble in the affected part, decortication, second degree burn, and transudate is more; Invalid after 2 weeks of hospitalize, adopt 10 parts of Herba Melastomatis Candiis, 15 parts of Radix Helicteriss, 10 parts of Folium Malloti Apeltaes, 10 parts of Fruticose Breyniae Leaf and Twigs, 10 parts of Herba Taxillis, 10 parts of Raphiolepis indicas, add 2 parts of furazolidones.The said medicine composition dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, and apply medicated powder and get final product, one day twice, continuous 4 days, wound healing, dead bark comes off, preventing from scar.
Case four
The literary composition certain, man, 36 years old; Scalds of motorcycle exhaust pipe shank, affected part bubble, decortication, and transudate is more; Second degree burn, affected part area 10 * 15CM is invalid after 2 weeks of hospitalize; Adopt 15 parts of Herba Melastomatis Candiis, 15 parts of Radix Helicteriss, 18 parts of Folium Malloti Apeltaes, 15 parts of Fruticose Breyniae Leaf and Twigs, 15 parts of Herba Taxillis, 15 parts of Raphiolepis indicas, add 3 parts of furazolidones.The said medicine composition dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, and apply medicated powder and get final product, one day twice, continuous 5 days, wound healing, dead bark comes off, preventing from scar.
Case five
The field, the woman 50 years old, suffers from diabetes for many years; Bubble in affected part, burn back, decortication, and transudate is more, second degree burn; Invalid after the hospitalize, adopt 15 parts of Herba Melastomatis Candiis, 20 parts of Radix Helicteriss, 20 parts of Folium Malloti Apeltaes, 15 parts of Fruticose Breyniae Leaf and Twigs, 15 parts of Herba Taxillis, 15 parts of Raphiolepis indicas, add 2 parts of furazolidones.The said medicine composition dried grind, and through treatment of wounds, clean wound need not to remove the bleb skin, external application, only needs squirt the affected part with disinfectant solution when changing dressings to the affected part, and apply medicated powder and get final product, one day twice, continuous 5 days, wound healing, dead bark comes off, preventing from scar.
In fact, in the medical practice in nearly ten years of the applicant, the case number of healing is numerous, all obtains good effect, and with low cost, alleviates the burden of sufferer.
The said treatment burn of application of the present invention, the medicine of scalding, cost is low, and is evident in efficacy, cures the back preventing from scar, has broad application prospects.
Claims (5)
1. medicine of treating burn, scalding, by pharmaceutical composition and/or pharmaceutically the acceptable carrier form, it is characterized in that described pharmaceutical composition comprises the various crude drug of following weight portion:
Herba Melastomatis Candii: 10-20 part, Radix Helicteris: 15-25 part, Folium Malloti Apeltae: 10-25 part;
Fruticose Breyniae Leaf and Twig: 10-20 part, Herba Taxilli: 10-20 part, Raphiolepis indica: 10-20 part.
2. treatment burn according to claim 1, the medicine of scalding is characterized in that the various crude drug of the preferred following weight portion of described pharmaceutical composition:
Herba Melastomatis Candii: 15 parts, Radix Helicteris: 20 parts, Folium Malloti Apeltae: 20 parts;
The Fruticose Breyniae Leaf and Twig: 15 parts, Herba Taxilli: 15 parts, Raphiolepis indica: 15 parts.
3. treatment burn according to claim 1, the medicine of scalding is characterized in that described pharmaceutical composition also comprises the antibiotic of 1-3 part.
4. treatment burn according to claim 3, the medicine of scalding is characterized in that described antibiotic comprises furazolidone.
5. the application of medicine in preparation treatment burn, scald medicament of claim 1 or 3 described treatment burns, scald.
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| CN 201010510481 CN102451249B (en) | 2010-10-18 | 2010-10-18 | Drug for treating burn and scald, and application thereof |
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| CN102451249A true CN102451249A (en) | 2012-05-16 |
| CN102451249B CN102451249B (en) | 2013-06-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845619A (en) * | 2014-02-28 | 2014-06-11 | 姚兴玲 | Traditional Chinese medicinal preparation for treating burn |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1214261A (en) * | 1998-10-21 | 1999-04-21 | 余际康 | Oral medicine for curing dermatosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1214261A (en) * | 1998-10-21 | 1999-04-21 | 余际康 | Oral medicine for curing dermatosis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845619A (en) * | 2014-02-28 | 2014-06-11 | 姚兴玲 | Traditional Chinese medicinal preparation for treating burn |
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