CN115068554A - Antibiotic substitute and preparation method thereof - Google Patents
Antibiotic substitute and preparation method thereof Download PDFInfo
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- CN115068554A CN115068554A CN202210816083.6A CN202210816083A CN115068554A CN 115068554 A CN115068554 A CN 115068554A CN 202210816083 A CN202210816083 A CN 202210816083A CN 115068554 A CN115068554 A CN 115068554A
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Abstract
The invention relates to the technical field of antibiotics, in particular to an antibiotic substitute and a preparation method thereof, wherein the antibiotic substitute is prepared from the following raw materials in parts by weight: 50-60 parts of sulfanilamide, 10-20 parts of Chinese pulsatilla root, 10-20 parts of coptis chinensis, 10-20 parts of golden cypress, 5-10 parts of Chinese angelica, 7-8 parts of honeysuckle, 15-20 parts of liquorice, 10-15 parts of cacumen biotae, 8-12 parts of myrobalan, 10-15 parts of rhizoma polygonati, 10-15 parts of wrinkled gianthyssop, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of mint and 5-10 parts of houttuynia cordata. The substitute of the antibiotics is prepared by using the common antibiotics sulfanilamide and the traditional Chinese medicinal materials, so that the using dosage of the common antibiotics is reduced, the effect of normal performance of the drug effect is ensured, the drug resistance of escherichia coli in a patient body caused by long-time administration of the sulfanilamide is avoided, the treatment period of the patient is shortened, meanwhile, the drug components are numerous, the action targets are increased, the escherichia coli can be further prevented from generating the drug resistance, the harm of the sulfanilamide to beneficial flora in the intestinal tract of the patient can be effectively relieved through the addition of the traditional Chinese medicinal material components, and the imbalance of the flora in the intestinal tract of the patient is avoided.
Description
Technical Field
The invention relates to the technical field of antibiotics, in particular to an antibiotic substitute and a preparation method thereof.
Background
According to statistics, China is a large producing country of antibiotics and a large using country of antibiotics. The antibiotic production raw materials are about 21 million tons every year, 3 million tons are exported, the other 18 million tons are self-used (including human, veterinary and agriculture and animal husbandry production), the annual consumption per capita is about 138g, while the annual consumption per capita is only 13g in the United states, and the antibiotic consumption per capita accounts for less than 10% in China. In addition, the use of antibiotics in livestock farming is more staggering each year. According to statistics, the amount of antibiotics used in feed additives is up to 600 tons in China every year, and accounts for 50 percent of the world.
Since the clinical application of oxytetracycline 1940, 10000 of the antibacterial drugs 5000-. The clinical application of the antibacterial drug greatly reduces the mortality rate of infectious diseases and the incidence rate of postoperative infection, and plays an extremely important role in improving the health level of human beings. Antibiotics have been used for more than 80 years, have been used for overcoming the infectious diseases of human beings, have put down the labor of sweaty horses, save countless lives, and statistically, the antibiotics prolong the average life of human beings by 10 years. At present, antibacterial drugs are the most widely used, fastest developing and most diverse drugs in the world as main drugs for treating bacterial infectious diseases.
Coli is a normal colonizer in the intestinal tract of animals, a small proportion of which causes disease under certain conditions. The serotype of escherichia coli can cause gastrointestinal infections of human or animals, mainly caused by infection with specific pilus antigens, pathogenic toxins and the like, and can cause urinary tract infection, arthritis, meningitis, sepsis type infection and the like besides gastrointestinal tract infection.
In the treatment process of escherichia coli, common antibiotics such as chloramphenicol, sulfanilamide, furan and the like are needed to be used for carrying out antibacterial treatment on the intestinal tract to eliminate the escherichia coli.
After a colibacillus patient takes antibiotics for a long time, certain drug resistance can be generated, beneficial flora in intestinal tracts can be destroyed, and after long-term application of the antibacterial drug, intestinal flora disorder can be caused, and double infection including bacterial infection and fungal infection can be caused.
Disclosure of Invention
The present invention aims to provide an antibiotic substitute and a preparation method thereof, so as to solve the problems in the background technology. In order to achieve the purpose, the invention provides the following technical scheme: the antibiotic substitute is prepared from the following raw materials in parts by weight: 50-60 parts of sulfanilamide, 10-20 parts of Chinese pulsatilla root, 10-20 parts of coptis chinensis, 10-20 parts of golden cypress, 5-10 parts of Chinese angelica, 7-8 parts of honeysuckle, 15-20 parts of liquorice, 10-15 parts of cacumen biotae, 8-12 parts of myrobalan, 10-15 parts of rhizoma polygonati, 10-15 parts of wrinkled gianthyssop, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of mint and 5-10 parts of houttuynia cordata.
Preferably, the antibiotic substitute is prepared from the following raw materials in parts by weight: 55 parts of sulfanilamide, 15 parts of Chinese pulsatilla root, 15 parts of coptis root, 15 parts of golden cypress, 7 parts of Chinese angelica, 7 parts of honeysuckle, 17 parts of liquorice, 13 parts of cacumen biotae, 10 parts of myrobalan, 13 parts of rhizoma polygonati, 13 parts of wrinkled gianthyssop herb, 17 parts of rhizoma anemarrhenae, 8 parts of mint and 8 parts of houttuynia cordata.
Preferably, the method comprises the following steps:
step one, putting a proper amount of Chinese pulsatilla root, coptis root, phellodendron bark, Chinese angelica, honeysuckle flower, liquorice, cacumen biotae, myrobalan, rhizoma polygonati, wrinkled gianthyssop, rhizoma anemarrhenae, mint and houttuynia cordata into a cleaning tank according to a proportion for cleaning;
step two, putting the medicinal materials cleaned in the step one into a traditional Chinese medicine decocting pot to decoct to obtain a product A;
step three, homogenizing and drying the product A in the step two to obtain a product B;
and step four, adding sulfanilamide powder into the doped product B in proportion, mixing and tabletting to prepare the substitute of the antibiotic.
Preferably, the washing step comprises:
firstly, placing a proper amount of medicinal materials into a cleaning pool, soaking for 10-15 minutes, and stirring at a constant speed to enable dust or soil on the surfaces of the medicinal materials to be completely soaked in clear water, wherein the medicinal materials are rubbed with each other in the process of stirring at the constant speed to enable the dust or soil to be separated from the surfaces of the medicinal materials;
and step two, fishing out the cleaned and soaked medicinal materials, picking out impurities in the medicinal materials, placing the medicinal materials on a water control frame, and controlling the water to be dry.
Preferably, the step of decocting comprises:
step one, placing the cleaned medicinal materials into a frying pan, adding clear water into the frying pan, and submerging the clear water above the medicinal materials by 2-3 cm;
step two, decocting with strong fire until clear water in the frying pan is boiled, adjusting the fire after the clear water is boiled to slow fire to keep the clear water in the frying pan slightly boiling, and continuing to decoct;
step three, adding clear water into the frying pan when the water level of the clear water in the frying pan is reduced to be level with the medicinal materials;
and step four, filtering the liquid medicine obtained in the step three everywhere, collecting and containing the liquid medicine into a sterile container, and finishing decoction of the medicinal materials to obtain a product A.
Preferably, the number of times of adding the clean water is 4-5 times.
Preferably, the step of homogeneously drying comprises:
step one, pouring the liquid medicine into a stirrer for stirring, and enabling the liquid medicine to shred dispersed phases of the liquid medicine into particles and disperse the particles in continuous phases under the action of shearing force of the stirrer to form emulsion homogeneous phase substances;
and step two, putting the milky homogeneous phase substance in the step one into an atomization dryer for atomization drying treatment to make the milky homogeneous phase substance be powdery to obtain a product B.
Preferably, the temperature condition for homogenizing the liquid medicine by the homogenizer is 20-30 ℃.
Preferably, the step of mixing and tabletting comprises:
adding sulfanilamide powder into the product B in proportion and fully mixing by using a mixing stirrer to obtain a mixture C;
and step two, compressing the mixture C obtained in the step one into tablets by using a tablet press to obtain the antibiotic substitute.
Preferably, the antibiotic substitute can be used for escherichia coli, viral infections, infectious tracheitis, or infectious bronchitis.
Compared with the prior art, the invention has the beneficial effects that:
1. the substitute of the antibiotics is prepared by using the common antibiotics sulfanilamide and the traditional Chinese medicinal materials, so that the using dosage of the common antibiotics is reduced, the effect of the drugs is ensured to be normally exerted, the drug resistance of escherichia coli in a patient body caused by long-time administration of sulfanilamide is avoided, the treatment period of the patient is shortened, meanwhile, the drug components are numerous, the action targets are increased, and the drug resistance of the escherichia coli can be further prevented.
2. Through the addition of the traditional Chinese medicinal materials, the harm of sulfanilamide to beneficial flora in intestinal tracts of patients can be effectively relieved, and the imbalance of flora in the intestinal tracts of the patients is avoided, so that external bacteria enter while being deficient, exogenous infection is generated, and double infection, including the infection of bacteria and fungi, is caused.
3. Avoids adverse reaction caused by taking a large amount of sulfanilamide for a long time, and causes other symptoms of the body of a patient.
4. Avoid the situations of anaphylaxis, allergic urticaria and anaphylactic shock caused by taking a large amount of sulfanilamide for a long time.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The invention provides a technical scheme that: the antibiotic substitute is prepared from the following raw materials in parts by weight: 50-60 parts of sulfanilamide, 10-20 parts of Chinese pulsatilla root, 10-20 parts of coptis chinensis, 10-20 parts of golden cypress, 5-10 parts of Chinese angelica, 7-8 parts of honeysuckle, 15-20 parts of liquorice, 10-15 parts of cacumen biotae, 8-12 parts of myrobalan, 10-15 parts of rhizoma polygonati, 10-15 parts of wrinkled gianthyssop, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of mint and 5-10 parts of houttuynia cordata.
In the embodiment, the antibiotic substitute is prepared from the following raw materials in parts by weight: 55 parts of sulfanilamide, 15 parts of Chinese pulsatilla root, 15 parts of coptis root, 15 parts of golden cypress, 7 parts of Chinese angelica, 7 parts of honeysuckle, 17 parts of liquorice, 13 parts of cacumen biotae, 10 parts of myrobalan, 13 parts of rhizoma polygonati, 13 parts of wrinkled gianthyssop herb, 17 parts of rhizoma anemarrhenae, 8 parts of mint and 8 parts of houttuynia cordata.
The sulfanilamide is a main raw material for synthesizing sulfanilamide medicines, is used for preparing crystal sulfanilamide for external use to diminish inflammation, and can also be used for synthesizing other sulfanilamide medicines such as sulphaguanidine, sulfamethoxyzine, sulfamethazine and the like which are common antibiotic medicines, the pulsatilla chinensis is a dry root of pulsatilla chinensis which is a plant of Ranunculaceae, and the pulsatilla chinensis prefers cool and dry climate, is cold-resistant, drought-resistant and not high-temperature-resistant, grows in plain or low mountain slope grassland, forest edge or arid and litharge slope, is bitter and cold, has the effects of clearing heat, detoxifying, cooling blood and stopping dysentery, is commonly used for treating heat-toxin and bloody dysentery and pruritus leukorrhagia, and can be used for treating escherichia coli, coptis chinensis clearing heat, drying dampness, purging fire and detoxifying. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese character) processed with wine is good at clearing heat in upper energizer and can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian clears stomach and prevents vomiting, and is used for cold and heat mutual combination, damp-heat obstruction in middle energizer, fullness and vomiting, Yu Huang Lian soothes liver and stomach and prevents vomiting. It can be used for treating incoordination between liver and stomach, emesis, acid regurgitation, and cardiovascular and cerebrovascular diseases, and has antibacterial, antifungal, antiviral, and amebic inhibiting effects, and is used for treating damp-heat dysentery, jaundice, dark urine, leukorrhagia, pudendal pruritus, heat stranguria, tinea pedis, cramped, bone steaming, fatigue, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. The antibiotic substitute is used for treating fire excess from yin deficiency, night sweat and bone steaming, and comprises Chinese angelica, honeysuckle, liquorice, cacumen biotae, myrobalan, rhizoma polygonati, agastache rugosus, rhizoma anemarrhenae, mint and houttuynia cordata, so that the action targets of the antibiotic substitute are increased to prevent escherichia coli from generating drug resistance.
In this embodiment, the method includes the following steps:
step one, putting a proper amount of Chinese pulsatilla root, coptis root, phellodendron bark, Chinese angelica, honeysuckle flower, liquorice, cacumen biotae, myrobalan, rhizoma polygonati, wrinkled gianthyssop, rhizoma anemarrhenae, mint and houttuynia cordata into a cleaning tank for cleaning according to a proportion, so as to prevent impurities and dust in medicinal materials from influencing the quality of the medicaments;
step two, putting the medicinal materials cleaned in the step one into a traditional Chinese medicine decocting pot to decoct to obtain a product A;
step three, homogenizing and drying the product A in the step two to obtain a product B;
and step four, adding sulfanilamide powder into the doped product B according to a proportion, mixing and tabletting to prepare the substitute of the antibiotic.
In this embodiment, the cleaning step includes:
firstly, placing a proper amount of medicinal materials into a cleaning pool, soaking for 10-15 minutes, and stirring at a constant speed to enable dust or soil on the surfaces of the medicinal materials to be completely soaked in clear water, wherein the medicinal materials are rubbed with each other in the process of stirring at the constant speed to enable the dust or soil to be separated from the surfaces of the medicinal materials;
and step two, fishing out the cleaned and soaked medicinal materials, picking out impurities in the medicinal materials, placing the medicinal materials on a water control frame, and controlling the water to be dry.
In this embodiment, the decocting step includes:
step one, placing cleaned medicinal materials into a frying pan, adding clear water into the frying pan and submerging the medicinal materials above the medicinal materials by 2-3 cm, so that medicinal materials are prevented from being adhered to the bottom of the frying pan due to too little clear water, and liquid medicine is prevented from overflowing out of the frying pan when the medicinal materials are decocted due to too much clear water;
step two, decocting with strong fire until clear water in the frying pan is boiled, adjusting the fire after the clear water is boiled to slow fire to keep the clear water in the frying pan slightly boiling, and continuing to decoct;
adding clear water into the frying pan when the water level of the clear water in the frying pan is reduced to be level with the medicinal materials;
and step four, filtering the liquid medicine obtained in the step three everywhere, collecting and containing the liquid medicine into a sterile container, and finishing decoction of the medicinal materials to obtain a product A.
In the embodiment, the frequency of adding the clear water is 4-5 times, and the water can be added again for decoction when the concentrations of the internal solution and the external solution of the medicinal materials reach the balance and are not dissolved out, so that the effective components can be continuously dissolved out, and the process is repeated for 4-5 times.
In this embodiment, the step of homogenizing and drying includes:
step one, pouring the liquid medicine into a stirrer for stirring, and enabling the liquid medicine to shred dispersed phases of the liquid medicine into particles and disperse the particles in continuous phases under the action of shearing force of the stirrer to form emulsion homogeneous phase substances;
and step two, putting the milky homogeneous phase substance in the step one into an atomization dryer for atomization drying treatment to make the milky homogeneous phase substance be powdery to obtain a product B.
In the embodiment, the temperature condition of homogenizing the liquid medicine by the homogenizer is 20-30 ℃, and the homogenizing time can be shortened by 20-30 ℃, so that the preparation speed of the antibiotic substitute is increased.
In this example, the step of mixing tablets comprises:
adding sulfanilamide powder into the product B in proportion and fully mixing by using a mixing stirrer to obtain a mixture C, so that sulfanilamide and the product B can be uniformly mixed, and the problem that the pesticide effect of the substitute is unstable due to the fact that the sulfanilamide and the product B in the substitute are not uniformly distributed is avoided;
step two, the mixture C obtained in the step one is compressed into tablets by using a tablet machine to obtain the antibiotic substitute, and the powdered mixture C is tabletted into tablet medicaments, so that the tablet medicaments can be conveniently taken by patients, and the situation that the powdered mixture C is inconvenient to store and easy to scatter and waste is avoided.
In the embodiment, the antibiotic substitute can be used for escherichia coli, viral infection, infectious tracheitis or infectious bronchitis, the recovery time of a plurality of patients in a certain hospital after treatment by using the substitute is shortened by 15.5 percent, meanwhile, the patients do not have obvious drug resistance, and the flora in the patients does not have obvious imbalance.
Claims (10)
1. An antibiotic substitute characterized by: the antibiotic substitute is prepared from the following raw materials in parts by weight: 50-60 parts of sulfanilamide, 10-20 parts of Chinese pulsatilla root, 10-20 parts of coptis chinensis, 10-20 parts of golden cypress, 5-10 parts of Chinese angelica, 7-8 parts of honeysuckle, 15-20 parts of liquorice, 10-15 parts of cacumen biotae, 8-12 parts of myrobalan, 10-15 parts of rhizoma polygonati, 10-15 parts of wrinkled gianthyssop, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of mint and 5-10 parts of houttuynia cordata.
2. An antibiotic substitute as claimed in claim 1, wherein: the antibiotic substitute is prepared from the following raw materials in parts by weight: 55 parts of sulfanilamide, 15 parts of Chinese pulsatilla root, 15 parts of coptis root, 15 parts of golden cypress, 7 parts of Chinese angelica, 7 parts of honeysuckle, 17 parts of liquorice, 13 parts of cacumen biotae, 10 parts of myrobalan, 13 parts of rhizoma polygonati, 13 parts of wrinkled gianthyssop herb, 17 parts of rhizoma anemarrhenae, 8 parts of mint and 8 parts of houttuynia cordata.
3. The method of claim 1, wherein the antibiotic substitute is prepared by: the method comprises the following steps:
step one, putting a proper amount of Chinese pulsatilla root, coptis root, phellodendron bark, Chinese angelica, honeysuckle flower, liquorice, cacumen biotae, myrobalan, rhizoma polygonati, wrinkled gianthyssop, rhizoma anemarrhenae, mint and houttuynia cordata into a cleaning tank according to a proportion for cleaning;
step two, putting the medicinal materials cleaned in the step one into a traditional Chinese medicine decocting pot to decoct to obtain a product A;
step three, homogenizing and drying the product A in the step two to obtain a product B;
and step four, adding sulfanilamide powder into the doped product B in proportion, mixing and tabletting to prepare the substitute of the antibiotic.
4. The method of claim 3, wherein the antibiotic substitute is prepared by: the cleaning step comprises:
firstly, placing a proper amount of medicinal materials into a cleaning pool, soaking for 10-15 minutes, and stirring at a constant speed to enable dust or soil on the surfaces of the medicinal materials to be completely soaked in clear water, wherein the dust or soil on the surfaces of the medicinal materials are rubbed with each other in the process of stirring at the constant speed to enable the dust or soil to be separated from the surfaces of the medicinal materials;
and step two, fishing out the cleaned and soaked medicinal materials, picking out impurities in the medicinal materials, placing the medicinal materials on a water control frame, and controlling the water to be dry.
5. The method of claim 3, wherein the antibiotic substitute is prepared by: the step of decocting comprises:
step one, putting the cleaned medicinal materials into a frying pan, adding clear water into the frying pan and submerging the medicinal materials by 2-3 cm above the medicinal materials;
step two, decocting with strong fire until clear water in the frying pan is boiled, adjusting the fire after the clear water is boiled to slow fire to keep the clear water in the frying pan slightly boiling, and continuing to decoct;
adding clear water into the frying pan when the water level of the clear water in the frying pan is reduced to be level with the medicinal materials;
and step four, filtering the liquid medicine obtained in the step three everywhere, collecting and containing the liquid medicine into a sterile container, and decocting the medicinal materials to obtain a product A.
6. The method of claim 5, wherein the antibiotic substitute is prepared by: the number of times of adding clear water is 4-5 times.
7. The method of claim 3, wherein the antibiotic substitute is prepared by: the step of homogenizing and drying comprises:
step one, pouring the liquid medicine into a stirrer for stirring, and enabling the liquid medicine to shred a liquid medicine dispersion phase into particles under the action of shearing force of the stirrer to be dispersed in a continuous phase to form an emulsion (like homogeneous phase;
and step two, putting the milky homogeneous phase substance in the step one into an atomization dryer for atomization drying treatment to make the milky homogeneous phase substance be powdery to obtain a product B.
8. The method of claim 7, wherein the antibiotic substitute is prepared by: the temperature condition of the homogenizer for homogenizing the liquid medicine is 20-30 ℃.
9. The method of claim 3, wherein the antibiotic substitute is prepared by: the step of mixed tabletting comprises:
adding sulfanilamide powder into the product B in proportion and fully mixing by using a mixing stirrer to obtain a mixture C;
and step two, compressing the mixture C obtained in the step one into tablets by using a tablet press to obtain the antibiotic substitute.
10. An antibiotic substitute as claimed in claim 2, wherein: the antibiotic substitute can be used for escherichia coli, viral infection, infectious tracheitis or infectious bronchitis.
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| CN1200289A (en) * | 1997-05-24 | 1998-12-02 | 金文媺 | Sanhua xietingye liquid medicine for treating diarrhea made of three flowers |
| CN103860835A (en) * | 2012-12-10 | 2014-06-18 | 广东高山动物药业有限公司 | Multipurpose veterinary drug of pure traditional Chinese medicine preparation |
| CN106491769A (en) * | 2016-12-31 | 2017-03-15 | 王志勇 | The Traditional Chinese medicine compound gel agent for the treatment of wound, preparation method and applications |
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2022
- 2022-07-12 CN CN202210816083.6A patent/CN115068554A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1200289A (en) * | 1997-05-24 | 1998-12-02 | 金文媺 | Sanhua xietingye liquid medicine for treating diarrhea made of three flowers |
| CN103860835A (en) * | 2012-12-10 | 2014-06-18 | 广东高山动物药业有限公司 | Multipurpose veterinary drug of pure traditional Chinese medicine preparation |
| CN106491769A (en) * | 2016-12-31 | 2017-03-15 | 王志勇 | The Traditional Chinese medicine compound gel agent for the treatment of wound, preparation method and applications |
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Application publication date: 20220920 |