CN109200233B - Medicine for treating bacterial diseases of lumbricus and preparation method thereof - Google Patents

Medicine for treating bacterial diseases of lumbricus and preparation method thereof Download PDF

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CN109200233B
CN109200233B CN201811257423.6A CN201811257423A CN109200233B CN 109200233 B CN109200233 B CN 109200233B CN 201811257423 A CN201811257423 A CN 201811257423A CN 109200233 B CN109200233 B CN 109200233B
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parts
medicine
mixture
decocting
dandelion
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CN109200233A (en
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周厚成
何洁东
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Sichuan Neo Green Pharmaceutical Technology Development Co ltd
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Sichuan Neo Green Pharmaceutical Technology Development Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A—HUMAN NECESSITIES
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    • A01N65/08—Magnoliopsida [dicotyledons]
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    • A—HUMAN NECESSITIES
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    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
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Abstract

The invention discloses a medicament for treating bacterial diseases of lumbricus and a preparation method thereof, wherein the medicament comprises the following raw materials in parts by mass: 50-65 parts of honeysuckle, 10-40 parts of dandelion, 20-30 parts of liquorice, 10-20 parts of isatis root and 5-8 parts of radix stemonae. The preparation method comprises pulverizing Glycyrrhrizae radix, radix Isatidis and radix Stemonae to obtain raw material powder, decocting flos Lonicerae and herba Taraxaci in water, concentrating the decoction to obtain extract, mixing the raw material powder and the extract, and adding adhesive and stirring to obtain the final product. The medicament can greatly reduce the incidence probability of common diseases of the earthworms and has good control effect on insect pests and bacteria general. By adopting the medicine of the invention, the problem that the growth of the earthworms is influenced by plant diseases and insect pests can be effectively solved.

Description

Medicine for treating bacterial diseases of lumbricus and preparation method thereof
Technical Field
The invention belongs to the technical field of pharmacy, and particularly relates to a medicament for treating bacterial diseases of lumbricus and a preparation method thereof.
Background
Earthworm is one of the important Chinese medicinal materials in China. Has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting urination. After being stir-baked, the Chinese medicinal composition is used for treating high fever, coma, fright epilepsy and convulsion, arthralgia, cough and asthma due to lung heat, oliguria and edema, hypertension and the like. Contains multiple amino acids. The raw material should be stir-baked because of its strong fishy smell.
In the process of artificial feeding, the earth fed by the feed contains more insect pests and germs, so that the earthworms have poor nutrition, relatively slow growth speed and higher morbidity, and the output of the earthworms is seriously influenced.
Disclosure of Invention
Aiming at the prior art, the invention provides a medicine for treating bacterial diseases of earthworms and a preparation method thereof, which aim to solve the problem that diseases and insect pests influence the growth of earthworms.
In order to achieve the purpose, the invention adopts the technical scheme that: the invention provides a medicament for treating bacterial diseases of lumbricus, which is characterized by comprising the following raw materials in parts by mass: 50-65 parts of honeysuckle, 10-40 parts of dandelion, 20-30 parts of liquorice, 10-20 parts of isatis root and 5-8 parts of radix stemonae.
The raw materials of the medicine have the following effects:
licorice, belonging to the family Leguminosae, is a perennial herb with strong root and rhizome, and is a tonifying Chinese herbal medicine. The medicinal part is root and rhizome, and the medicinal root is cylindrical, 25-100 cm long and 0.6-3.5 cm in diameter. Can be used for treating carbuncle, ulcer, sore and sore throat; it can be used singly, orally or externally, or combined.
Radix isatidis is a Chinese medicinal material. Bitter and cold. Has the effects of clearing away heat and toxic materials, cooling blood and relieving sore throat. It is commonly used for epidemic febrile disease, fever, pharyngalgia, epidemic macula, mumps, erysipelas, fever with swollen head, erysipelas, and carbuncle.
Honeysuckle flower, flos Lonicerae, is known as good medicine for clearing heat and removing toxicity from ancient times. It is sweet and cold in nature and fragrant, sweet and cold in nature and clearing heat without hurting stomach, and the fragrance is thorough and can eliminate pathogens. The honeysuckle can disperse wind-heat and clear away blood toxin, and has obvious effect on various heat diseases such as fever, eruption, macula, sore and carbuncle due to heat toxin, sore throat and the like.
Dandelion, dandelion of the family Compositae, taraxacum, perennial herbs of the genus Taraxacum. The body contains various healthy nutritional ingredients such as taraxol, taraxacin, choline, organic acid, inulin, etc. Sweet in nature and taste, slightly bitter and cold. It enters liver and stomach meridians. Has diuretic, laxative, jaundice treating, and gallbladder promoting effects. It is used to treat heat-toxin, carbuncle, pyocutaneous disease, internal carbuncle, conjunctival congestion, swelling and pain, damp-heat, jaundice, stranguria with urine, furuncle, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, damp-heat jaundice, and stranguria with pain.
Stemona is dried root tuber of Stemona sessilifolia, Stemona tuberosa or Stemona tuberosa of Stemona of Stemonaceae. Has the effects of moistening lung, descending qi, relieving cough, killing parasites and killing lice. It is commonly used for cough due to new or old age, cough due to tuberculosis, and cough due to lung stagnation; it is used for treating head louse, body louse, enterobiasis, and pudendal pruritus. Honey radix Stemonae can moisten lung to relieve cough, and can be used for treating cough due to yin deficiency.
The honeysuckle, the dandelion, the liquorice and the radix isatidis in the traditional Chinese medicine have the disease-resistant and inflammation-diminishing functions, the radix stemonae has the insect-expelling function, the honeysuckle and the dandelion are used as monarch drugs, the radix isatidis and the liquorice are used as ministerial drugs, the radix stemonae is used as an assistant and guide drug, and the anti-inflammatory and inflammation-diminishing drug properties of the drugs are increased and the treatment effect on infectious and inflammatory diseases is remarkably increased after the drugs are matched according to the proportion in the traditional Chinese medicine according to the monarch, ministerial, assistant and guide principles.
The medicine of the present invention may be further modified as follows.
Further, the medicine comprises the following raw materials in parts by mass: 55 parts of honeysuckle, 20 parts of dandelion, 25 parts of liquorice, 15 parts of isatis root and 6 parts of radix stemonae.
Further, the medicine also comprises 10-15 parts of chlorine dioxide disinfectant.
The chlorine dioxide disinfectant is an internationally accepted high-efficiency disinfectant, can kill all microorganisms including viruses, bacteria, protists, algae, fungi, various spores and thalli formed by the spores and the like, and can prevent the bacteria from generating drug resistance. Chlorine dioxide has strong adsorption and penetration capacity on microbial cell walls, can effectively oxidize enzymes containing sulfydryl in cells, can also quickly inhibit the synthesis of microbial protein to destroy microbes, and can efficiently eliminate germs in soil and algae in water by matching with the traditional Chinese medicine components, thereby greatly reducing the probability of disease occurrence.
The preparation method of the medicine comprises the following steps:
s1, respectively crushing the liquorice, the isatis root and the stemona root to 100-130 meshes to obtain raw material powder;
s2, uniformly mixing honeysuckle and dandelion, adding 8-12 times of purified water into the mixture, decocting for 2-3 hours, filtering, adding 8-10 times of pure water into filter residues, continuously decocting for 2-3 hours, filtering, and combining filtrates;
s3, concentrating the combined filtrate in the S2 until the relative density is 1.0-1.15 g/cm3Obtaining extract, adding the raw material powder obtained in the step S1 and the chlorine dioxide disinfectant into the extract, and uniformly mixing to obtain a primary medicament product;
s4, uniformly mixing the primary medicine with the adhesive, and making the mixture into pills or tablets to obtain the finished medicine.
The preparation method of the invention can be further modified as follows.
Further, in the first decoction in the step S2, 10 times of purified water is added into the mixture of the honeysuckle and the dandelion and the mixture is decocted for 3 hours; when decocting again, 8 times of purified water is added into the filter residue and decocting is carried out for 2 h.
Further, the preparation method of the finished product of the medicine in the S4 comprises the following steps: uniformly mixing the primary medicine and the adhesive according to the mass ratio of 1: 3-5, and preparing the mixture into a mixture with the hardness of 5.0-8.0 kg/cm through a granulator2And tablets with a diameter of 2.5-3 cm and a thickness of 0.2-0.3 cm.
Further, the binder is starch.
The invention has the beneficial effects that:
1. the medicine has good sterilization and algae removal effects, fast action, no influence of pH value on sterilization capability, no carcinogen generation after action, good stability before use, timely and complete activation during use and lasting action after administration.
2. The medicine of the invention can treat diseases, the stemona root in the medicine can kill insects in soil, and the added starch is a favorite food of lumbricus, thus greatly improving the utilization rate of the medicine.
3. The medicine of the invention has low cost and reduces the breeding cost.
4. The medicine of the invention contains medicinal components, thus reducing the use of antibiotics in the feeding process.
Detailed Description
The following examples are provided to illustrate specific embodiments of the present invention.
Example one
The drug is a tablet and comprises the following raw materials in parts by mass: 55 parts of honeysuckle, 20 parts of dandelion, 25 parts of liquorice, 15 parts of isatis root and 6 parts of radix stemonae, and the specific preparation method comprises the following steps:
s1, respectively pulverizing 25 qian liquorice, 15 qian isatis root and 6 qian stemona root into 130 meshes to obtain raw material powder;
s2, taking 55 coins of honeysuckle and 20 coins of dandelion, uniformly mixing the honeysuckle, the dandelion and the dandelion, adding 10 times of purified water into the mixture, decocting the mixture for 0.5 hour by strong fire, then decocting the mixture for 2.5 hours by changing the slow fire, then filtering the mixture, adding 8 times of pure inlet water into filter residues, decocting the mixture for 0.25 hour by strong fire, then decocting the mixture for 1.75 hours by changing the slow fire, filtering the mixture, and combining the filtrates;
s3 concentrating the combined filtrate of S2 to a relative density of about 1.1 g/cm3(65 ℃) to obtain extract, adding the raw material powder obtained in the step S1 and 10-coin chlorine dioxide disinfectant into the extract, and uniformly mixing to obtain a primary medicine product;
s4, uniformly mixing the primary medicine product and starch according to the mass ratio of 1:3, and preparing the mixture into the product with the hardness of 5.0 kg/cm through a granulator2And tablets with the diameter of 3 cm and the thickness of 0.2 cm are put into an anti-moisture-absorption interior-plated aluminum-plated kraft paper bag according to the specification of 20-50 tablets/bag and are stored in a warehouse.
Example two
The drug is a tablet and comprises the following raw materials in parts by mass: 55 parts of honeysuckle, 20 parts of dandelion, 25 parts of liquorice, 15 parts of isatis root and 6 parts of radix stemonae, and the specific preparation method comprises the following steps:
s1, respectively pulverizing 20 coins of radix Glycyrrhizae, 20 coins of radix Isatidis, and 5 coins of radix Stemonae to 100 meshes to obtain raw material powder;
s2, taking 50 coins of honeysuckle and 40 coins of dandelion, uniformly mixing the honeysuckle and the dandelion, adding 10 times of purified water into the mixture, decocting the mixture for 0.5 hour by strong fire, then decocting the mixture for 2.5 hours by changing the slow fire, then filtering the mixture, adding 8 times of pure inlet water into filter residues, decocting the mixture for 0.25 hour by strong fire, then decocting the mixture for 1.75 hours by changing the slow fire, filtering the mixture, and combining the filtrates;
s3 concentrating the combined filtrate of S2 to a relative density of about 1.0 g/cm3(65 ℃) to obtain extract, adding the raw material powder obtained in the step S1 and the 15-coin chlorine dioxide disinfectant into the extract, and uniformly mixing to obtain a primary medicine product;
s4, uniformly mixing the primary medicine product and starch according to the mass ratio of 1:4, and preparing the mixture into the product with the hardness of 6.0 kg/cm through a granulator22.5 cm in diameter and 2.5 cm in thicknessAnd (3) 0.3 cm tablets, filling the tablets into moisture-absorption-proof interior-plated aluminum kraft paper bags according to the specification of 20-50 tablets/bag, and warehousing and storing.
EXAMPLE III
The medicine for treating the bacterial diseases of the earthworms is a pill and comprises the following raw materials in parts by mass: 60 parts of honeysuckle, 20 parts of dandelion, 30 parts of liquorice, 10 parts of radix isatidis and 7 parts of radix stemonae, and the specific preparation method comprises the following steps:
s1, respectively pulverizing 30 qian licorice root, 10 qian isatis root and 7 qian stemona root into 130 meshes to obtain raw material powder;
s2, taking 60 coins of honeysuckle and 20 coins of dandelion, uniformly mixing the honeysuckle and the dandelion, adding 12 times of purified water into the mixture, decocting the mixture for 0.5 hour by strong fire, then decocting the mixture for 2.5 hours by changing the slow fire, then filtering the mixture, adding 10 times of pure inlet water into filter residues, decocting the mixture for 0.25 hour by strong fire, then decocting the mixture for 1.75 hours by changing the slow fire, filtering the mixture, and combining the filtrates;
s3 concentrating the combined filtrate of S2 to a relative density of about 1.15g/cm3(65 ℃) to obtain extract, adding the raw material powder obtained in the step S1 and 10-coin chlorine dioxide disinfectant into the extract, and uniformly mixing to obtain a primary medicine product;
s4, uniformly mixing the primary medicine and starch according to the mass ratio of 1:4, making the mixture into pills with the diameter of 1 cm by a pill making machine, filling the pills into moisture-proof internally-plated aluminum kraft paper bags according to the specification of 20-50 pills/bag, and warehousing for storage.
Example four
The medicine for treating the bacterial diseases of the earthworms is a pill and comprises the following raw materials in parts by mass: 65 parts of honeysuckle, 10 parts of dandelion, 20 parts of liquorice, 20 parts of radix isatidis and 8 parts of radix stemonae, and the specific preparation method comprises the following steps:
s1, respectively pulverizing 20 qian licorice root, 20 qian isatis root and 8 qian stemona root into 130 meshes to obtain raw material powder;
s2, taking 65 coins of honeysuckle and 10 coins of dandelion, uniformly mixing the honeysuckle, the dandelion and the dandelion, adding 10 times of purified water into the mixture, decocting the mixture for 0.5 hour by strong fire, then decocting the mixture for 2.5 hours by changing the slow fire, then filtering the mixture, adding 10 times of pure inlet water into filter residues, decocting the mixture for 0.25 hour by strong fire, then decocting the mixture for 1.75 hours by changing the slow fire, filtering the mixture, and combining the filtrates;
s3 concentrating the combined filtrate of S2 to a relative density of about 1.0 g/cm3(65 ℃) to obtain extract, adding the raw material powder obtained in the step S1 and the 15-coin chlorine dioxide disinfectant into the extract, and uniformly mixing to obtain a primary medicine product;
s4, uniformly mixing the primary medicine and starch according to the mass ratio of 1:5, making the mixture into pills with the diameter of 1 cm by a pill making machine, filling the pills into moisture-proof internally-plated aluminum kraft paper bags according to the specification of 20-50 pills/bag, and warehousing for storage.
Analysis of results
Two areas with the same area are formed in the same earthworm breeding area, one area is sprayed with the medicament of the invention, and the other area is not treated at all, so that earthworms in the area can grow freely. The spraying liquid medicine is prepared by adding water into the tablets in the first embodiment, wherein the water is added according to the proportion of adding 500 ml of water into one tablet of medicine, and the spraying liquid medicine is sprayed according to the proportion of 500 ml/m2The amount of (A) is used. After spraying, 30 times of sampling are carried out within 3 months, and the incidence probability of common diseases of earthworms in two areas is counted, and the result is shown in table 1.
TABLE 1 comparison of incidence rates of common diseases in Pheretima
Name (R) Earthworm gastrointestinal disease rate Erosive disease rate of lumbricus Rate of streptococcus longae Rate of respiratory disease in earthworms High fever of earthworm
Medicine feeding group 4% 2% 5% 7% 6%
Group of non-administration 6% 8% 11% 9% 11%
As can be seen from the table, after the medicine disclosed by the invention is used, the incidence probability of common earthworm diseases is remarkably reduced compared with that of a culture area without the medicine, and the medicine disclosed by the invention has good prevention and treatment effects on the common earthworm diseases. In addition, in order to test the pest control effect of the drug of the invention, the soil of the earthworm cultivation area is taken and filled with the ground area of 1 m2And a container with the height of 50 cm, the medicine of the invention is sprayed, 30 times of sampling is carried out within 3 months, the control ratio of the insect pests is counted, and the result is shown in table 2.
TABLE 2 Pest control Effect of the drugs
Name (R) Ant as health food Red spider Fly maggot The natural enemies of parasites of the earthworms include tapeworms, nematodes, fasciolopsis and parasitic flies
Control ratio 86% 92% 95% 85%
As can be seen from the table 2, the drug of the invention has good control effect on common pests and diseases in earthworm cultivation areas, and after the drug of the invention is used, the number of the pests can be greatly reduced, which is beneficial to the growth of earthworms.
Another important factor influencing the growth of earthworms is the content of bacteria in the culture area, and in order to test the sterilization effect of the medicament on the bacteria, the soil in the earthworm culture area is taken and filled into the earthworm culture area with the bottom area of 1 m2And a container with a height of 50 cm, the medicine of the present invention was sprayed, 30 samples were taken within 3 months, and the sterilization effect on bacteria was counted, and the results are shown in table 3.
TABLE 3 Sterilization Effect of drugs on bacteria
Name (R) The bacteria are mostly Bacillus The fungi mainly belong to Phycomycetes and Ascomycetes The virus is mainly a polyopsivirus
Killing effect 92% 89% 82%
As can be seen from Table 3, the medicament of the present invention has a good sterilization effect on harmful bacteria in the earthworm cultivation area, and after the medicament of the present invention is used, the number of harmful bacteria can be greatly reduced, which is beneficial to the growth of earthworms.
While the present invention has been described in detail with reference to the embodiments, it should not be construed as limited to the scope of the patent. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.

Claims (7)

1. The application of a pharmaceutical composition in preparing a medicament for treating bacterial diseases of lumbricus is characterized in that the pharmaceutical composition is prepared from the following raw materials in parts by mass: 50-65 parts of honeysuckle, 10-40 parts of dandelion, 20-30 parts of liquorice, 10-20 parts of isatis root and 5-8 parts of radix stemonae.
2. The application of the pharmaceutical composition of claim 1 in preparing a medicament for treating bacterial diseases of earthworms is characterized in that the pharmaceutical composition is prepared from the following raw materials in parts by mass: 55 parts of honeysuckle, 20 parts of dandelion, 25 parts of liquorice, 15 parts of isatis root and 6 parts of radix stemonae.
3. Use of a pharmaceutical composition according to claim 1 or 2 for the preparation of a medicament for the treatment of bacterial diseases of lumbricus, wherein: the pharmaceutical composition also comprises 10-15 parts of chlorine dioxide disinfectant.
4. Use according to claim 3, characterized in that the process for the preparation of the pharmaceutical composition comprises the following steps:
s1, respectively crushing the liquorice, the isatis root and the stemona root to 100-130 meshes to obtain raw material powder;
s2, uniformly mixing honeysuckle and dandelion, adding 8-12 times of purified water into the mixture, decocting for 2-3 hours, filtering, adding 8-10 times of pure water into filter residues, continuously decocting for 2-3 hours, filtering, and combining filtrates;
s3, concentrating the combined filtrate in the S2 until the relative density is 1.0-1.15 g/cm3Obtaining extract, adding the raw material powder obtained in the step S1 and the chlorine dioxide disinfectant into the extract, and uniformly mixing to obtain a primary medicament product;
s4, uniformly mixing the primary medicine with the adhesive, and making the mixture into pills or tablets to obtain the finished medicine.
5. Use according to claim 4, characterized in that: s2, adding 10 times of purified water into the mixture of honeysuckle and dandelion when decocting for the first time, and decocting for 3 hours; when decocting again, 8 times of purified water is added into the filter residue and decocting is carried out for 2 h.
6. Use according to claim 4, characterized in that: the preparation method of the finished product of the S4 traditional Chinese medicine comprises the following steps: uniformly mixing the primary medicine and the adhesive according to the mass ratio of 1: 3-5, and preparing the mixture into a mixture with the hardness of 5.0-8.0 kg/cm2And tablets with a diameter of 2.5-3 cm and a thickness of 0.2-0.3 cm.
7. Use according to claim 4 or 6, characterized in that: the adhesive is starch.
CN201811257423.6A 2018-10-26 2018-10-26 Medicine for treating bacterial diseases of lumbricus and preparation method thereof Active CN109200233B (en)

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