CN103689010A - Medicine for hog house disinfection - Google Patents
Medicine for hog house disinfection Download PDFInfo
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Abstract
The invention provides a special medicine for hog house disinfection. The traditional Chinese medicine composition for hog house disinfection and disease prevention has the advantages of convenience in availability of materials, no chemical injury, low cost and free of worry of meat commodity inspection. The medicine for hog house disinfection, provided by the invention, comprises cortex meliae, camphor tree leaves, myrrh, senecio scandens, lygodium japonicum, solidago decurrens, mastic, honeysuckle, mint, citrus peel, moutan bark, liriodendron bark, dandelion, denseflower indigo leaf, common carpesium fruit and calamus leaves.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of pig house sterilization medicine.
Background technology
Piggery major part is all being used lime as disinfectant at present.But there are many professional raising farmer usings method improper, cause Disinfection Effect bad.Specialist is in order to follow the line of least resistance, and disposablely buys much quicklime, once toos many or too much for use, and continues to be used as to sterilize later.This is incorrect, because quicklime chemical name generates loose white lime after in calcium oxide, adding water, if quicklime is placed in the container of sealing, also can absorb moisture in air, age lime, be slaked lime, only have the hydroxide ion that this dissociation goes out just to there is bactericidal action.If white lime is put of long duration, will with airborne carbonic acid gas chemically reactive, generate the calcium carbonate there is no hydroxide ion, completely lost the effect of sterilizing.If fresh white lime can play certain Disinfection Effect.If often do not change fresh white lime, and clothes, instrument etc. are not sterilized and still germ, virus can be brought in mew.If white lime is directly sprinkling upon in mew on ground, easily by limb hoof and the skin burn of pig, or the food (being stained with white lime) falling to the ground because of pig food burn oral cavity and digestive tract.When liming powder, can cause in addition lime dust to fly upward in a large number, pig is sucked in respiratory tract, the respiratory symptom such as cause cough, sneeze.
Raise pigs on a large scale, easily grow a lot of germs, in line with the principle that is conducive to epidemic preventing sanitary, it is completely inadequate that the cleaning of pig house every day is cleaned, it is indispensable being equipped with disinfection apparatus management, disinfection is the known by everybody problem in each pig farm, but is having a lot of raisers to think little of sterilization; Or do not know how to go sterilization, outwardly sterilized, in fact do not reach the object of sterilization.
The sterilization of pig house and extraneous sterilization are different, and because place there is no ight soil, pig house does not have the residues such as the anxious afterbirth of a large amount of fecalurias.And ight soil is can not being interrupted of constantly discharging, so thorough disinfection pig house need produce pig house pig, pig house is sterilized generally on every Mondays to twice, at least one times.About the use of thimerosal, some people thinks that concentration is the bigger the better, so in real work, the concentration of groups of people's proportioning, exceeds the ratio of explanation; Or some people is in order to save, the concentration of proportioning is less than the concentration on specification, and these are all wrong.
Summary of the invention
For the problems referred to above, the technical problem to be solved in the present invention is to provide a kind of medicine that aims at pig house sterilization use.Adopt this Chinese medicine composition that the prevention of pig farm sterilization and disease is had and drawn materials conveniently, without poisoning, cost is low, and meat is without the advantages such as sorrow of commodity inspection.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine of pig house sterilization use, it comprises: azedarach, camphortree leaf, myrrh, climbing groundsel, Lygodium japonicum, goldenrod, frankincense, honeysuckle, peppermint, orange peel, moutan bark, Chinese tuliptree bark, dandelion, denseflower indigo leaf, Lappula echinata and grassleaf sweetflag leaf, amount to 16 taste Chinese medicinal herbses.
Wherein, the ratio of weight and number of each component in described medicine is, described azedarach 50～60 weight portions, described camphortree leaf 30～35 weight portions, described myrrh 15～20 weight portions, described climbing groundsel 15～20 weight portions, described Lygodium japonicum 15～20 weight portions, described goldenrod 10～15 weight portions, described frankincense 20～25 weight portions, described honeysuckle 10～15 weight portions, described peppermint 10～15 weight portions, described orange peel 20～25 weight portions, described moutan bark 10～15 weight portions, described Chinese tuliptree bark 20～25 weight portions, described dandelion 20～25 weight portions, described denseflower indigo leaf 20～25 weight portions, described Lappula echinata 10～15 weight portions and described grassleaf sweetflag leaf 15～20 weight portions.
For solving the problems of the technologies described above, the present invention also provides a kind of pig house sterilization medicine, and described medicine is prepared from by the following method:
The first step, packs azedarach, myrrh, Lappula echinata, orange peel, moutan bark, Chinese tuliptree bark in multi-function extractor into, adds alcohol heating reflux to extract, merge extract, centrifugal, filter, obtain filtered fluid, reduced pressure concentration reclaims ethanol, obtain medicinal extract, by medicinal extract stored refrigerated, enter subsequently in spray dryer dry, with cracker, pulverize and sieve, obtaining granularity is 50～100 object powder;
Second step, will remain herbal raw material difference boiling 2～4 times, merge decoction liquor separately, filter, and static spending the night, extracts the upper strata stillness of night, and reduced pressure concentration, except anhydrating, is dried to respectively dry cream, pulverize and will sieve, acquisition 70～120 order powder;
The 3rd step, will be above-mentioned during use powder drop in agitator and be stirred to evenly under normal temperature and pressure conditions, be added to and in warm water, obtain described disinfection of Chinese drug medicine.
The pig house of cleaning out and pig, can be used medicine of the present invention directly to spray, rinse or spread upon on pig house and porcine skin, and not only sterilizing, prevent disease, also have the effect repelling mosquitoes and flies with deodorizing.
Wherein, the ratio of described medicine and warm water is 1:10.
As preferably, in described medicine, can also add acetic acid ratio is 1:10.
As preferably, in described medicine, can also add sulphanilamide crystal powder 10～15 weight portions.
Beneficial effect of the present invention:
With respect to of the prior art for disinfection and prophylactic sterilization method, the present invention adopts this Chinese medicine composition to have remarkable result to disinfection and prevent disease, and the present invention draws materials conveniently, and safety is without poisoning, cost is low, and meat is without the advantages such as sorrow of commodity inspection.
the pharmacology and the property of medicine that the present invention relates to Chinese medicine material are as follows:
Azedarach:
[nature and flavor] < < does not record > >: " be slightly cold." < < Japan hanako materia medica > >: " hardship, micro-poison." < < medical center nationality is wanted > >: " is bitter greatly, Great Cold."
[function cures mainly] heat-clearing, eliminating dampness, desinsection.Control roundworm, pinworm, rubella, mange.
[pharmacological action] 1, anthelmintic action: through pig test, show, this medicine decoction or alcohol extract all have and suppress so that paralysis effect ascaris suum.The active ingredient of driving ascarid effect is toosendanin, stronger than the effect of ethanol extract.The toosendanin of low concentration (1:5000-9000), whole piece ascaris suum and sections (head and middle part) thereof are had to obvious excitation, showing as spontaneous activity strengthens, there is off and on abnormal violent contraction, destroy its laws of motion (movable strengthen with weaken alternate), continue 10-24 hour, finally proceed to gradually spastic contraction.Toosendanin can see through polypide epidermis, directly acts on Ascaris Suum muscle, upsets its energy metabolism, causes contraction fatigue and spasm.The melia toosendan rope of this concentration is not blocked by atropine the excitation of roundworm nerve-muscle, and prompting toosendanin is not cholinomimetic.The toosendanin of high concentration (l:1000) to ascaris suum particularly the neuromere of head have paralysis effect.This paralysis effect may be that polypide is subject to be the result that intermittent cramp shrinks after drug effect.Through Ammon method and Warburg apparatus, measure respectively the cholinesterase activity of polypide homogenate and breathe glycolysis, result proof all has no significant effect, and shows that toosendanin is not to work by glycometabolism.In the experimental result of another ATP from Ascaris Suum muscle and Phos, can find out, toosendanin can make the katabolism of ATP accelerate, thereby causes roundworm to have energy supply shortage and cause fatigue of contraction, and is excreted.The azedarach liquid (25%-50%) of high concentration also has paralysis effect to mouse pinworm in vitro.2, the impact on respiratory center: heavy dose of toosendanin (every rat, vein or intramuscular injection 2mg) can cause rats breathing exhaustion.This is mainly due to the inhibitory action of this composition to maincenter.Medulla oblongata respiratory center position directly gives toosendanin (every rat 0.10-0.15mg), can support the above results.The respiration inhibition that central stimulant nikethamidum causes toosendanin has slight antagonism.3, the impact on Neuromuscular Transmission Function: toosendanin has and irreversibly checks the contraction of muscle that indirect stimulation causes rat, but the excitement not affecting the nerves conduction does not reduce the reaction of muscle to direct stimulation yet; Toosendanin is 1 and optionally acts on presynaptic neuromuscular transmission blocking agent.Its site of action is at presynaptic nerve teminal, and the mode of action is the acetylcholine release that suppresses to excite nerve and bring out.Electron microscope observation shows that toosendanin has obvious effect to the submicroscopic structure of small white mouse neuromuscular junction, shows that synaptic cleft width increases and synaptic vesicle decreased number.These two kinds variations appear at same joint when different.4, anti-botulismus: toosendanin has therapeutic action to botulismus animal.Mouse to lethal dose A type botulismus, gives toosendanin, has obvious therapeutic action for poisoning latter 6 hours; Monkey to lethal dose A type botulismus, gives toosendanin, can cure animals more than half for poisoning latter 24 hours; Mouse to Type B botulismus, toosendanin also has protective effect.In addition, toosendanin can obviously strengthen the therapeutic action of antitoxic serum to botulismus mouse and rabbit.5, the impact on heart nipple myoelectricity and mechanical property: the time-histories (APD 90) of fast response current potential multipole to 90% is extended chinaberry element concentration dependent, with barium chloride, block Ik1, can cancel the effect that toosendanin extends APD90, long response time electricity e Huai Pian PD is extended toosendanin and convergent force (FC) strengthens, with after barium chloride, can cancel the above-mentioned effect of toosendanin, but extend the effect existence of APD.In addition, toosendanin can make isolated frog heart shrink allorhythmic pulse, continues can automatically recover for l hour.6, other effects: chinaberry element (200mg/kg) rabbit gavage and concentration are 0.2 * 10(-4) toosendanin of mg all has remarkable increase to the tension force of rabbit in place and isolated rabbit intestines and convergent force.Concentration is 0.2 * l0(-3) toosendanin of mg can make myenteron present spastic contraction.This excitation can be resisted by diphenhydramine, and by atropine, is not blocked.10% azedarach infusion has inhibitory action to multiple pathogenic fungus.Melia extract for treating mouse experiment Manson's schistosomiasis, the aspects such as borer population and hatching test of living from animal body internal memory confirm there is certain curative effect.
Camphortree leaf:
[nature and flavor] < < Luchuan book on Chinese herbal medicine > >: " bitter is pungent, temperature."?
[function cures mainly] dispels the wind, dehumidifying, pain relieving, desinsection.Control treating rheumatic ostealgia, traumatic injury, mange.
Myrrh:
[nature and flavor] hardship, pungent, flat.
[function] is antibacterial, antimicrobial, anti-inflammatory, convergence, tool balosam speciality, deodorizing, the ventosity of dispelling, sterilization, diuresis, stimulate the menstrual flow, reduce phlegm, killing fungus, excitation, sharp stomach, urge sweat, mend body, sharp uterus, control wound, to ripe dry and cracked de-coarse skin helpful.
Climbing groundsel:
[meridian distribution of property and flavor] hardship, sweet, cold, pungent, cool.Nontoxic.
[function cures mainly] is clearing heat and detoxicating, desinsection, improving eyesight.Modern pharmacological research: 1, antibacterial action, has stronger antibacterial action to Shigella shigae, staphylococcus aureus, cured sample bacillus anthracis.2, anti-conveyor screw effect.3, suppress Trichomonas vaginalis effect.< < Chinese medicine voluminous dictionary > > report is used for the treatment of: various diseases associated with inflammation scabies impetigo poison, eczema, Trichomonas vaginalis, various vaginitis, cervicitis, ulcer, hemorrhoid etc.
Lygodium japonicum:
[nature and flavor] are cold in nature, and taste is sweet.Return bladder, small intestinl channel;
[function] has antibacterial, diuresis, for the infection of the upper respiratory tract, mumps, urinary tract infections etc.
Goldenrod:
[meridian distribution of property and flavor] is pungent, bitter, flat.Enter liver, courage two warps.
[function] wind and heat dispersing, anti-inflammation.For anemopyretic cold headache, (chill is avoided) is clearing heat and detoxicating, and detumescence is except pain.The infection of the upper respiratory tract, tonsillitis, abscess of throat, bronchitis, pneumonia, pulmonary tuberculosis hemoptysis, anxious, chronic nephritis, infantile malnutrition, traumatic injury is controlled in external application, venomous snake bite, sore swollen toxin, mastitis, 1, antibacterial action: decoction (causes the inflammation of suppurating to staphylococcus aureus in vitro, skin scabies carbuncle, infant bronchitis), Pseudomonas aeruginosa (pneumonia), dysentery (acute bacillary dysentery), typhoid bacillus (enteron aisle injury, avoid for a long time and be cautious use of, easily hemorrhage), Diplococcus pneumopniae (lobar pneumonia), α-hemolytic streptococcus (tonsillitis) and red moss bacterium, Candida albicans (belongs to fungi and causes the fungal infection of the hand, onychomycosis, the ringworm of the foot, women's colpomycosis) all there is inhibitory action.
Honeysuckle:
[nature and flavor] property is sweet, cold;
[function] has heat-clearing, removing toxic substances, anti-inflammatory, antibacterial effect.< < Compendium of Materia Medica > > carry " honeysuckle, being good at poison, therefore control ulcer, pyogenic infections, sore tinea ... ".Since ancient times, honeysuckle is usually used in clearing heat and detoxicating, the heating for the treatment of warm disease, and toxic-heat and blood stasis, the diseases such as large carbuncle, also for anemopyretic cold, the illnesss such as bronchitis.Modern pharmacological research shows, that honeysuckle has is antibacterial, antiviral, anti-inflammatory, antipyretic, regulate the effects such as immunity.
The loose poison of heat-clearing, < < Compendium of Materia Medica > > carry " honeysuckle, being good at is malicious, therefore control ulcer, pyogenic infections, sore tinea ... ".Since ancient times, honeysuckle is usually used in clearing heat and detoxicating, the heating for the treatment of warm disease, toxic-heat and blood stasis, the diseases such as large carbuncle.Modern pharmacological research shows, that honeysuckle has is antibacterial, antiviral, anti-inflammatory, antipyretic, regulate the effect traditional Chinese medical science such as immunity to think, honeysuckle is cold in nature, taste is sweet, gas is flat, has clearing heat and detoxicating effect, can treat the diseases such as hot malicious early stage of pyogenic infection of skin, ulcer furunculosis.And have the loose effect of a surname concurrently.Honeysuckle antipyretic and antidote functions is quite strong.Honeysuckle can delay the pathology effect of Respirovirus to cell, is the clearing heat and detoxicating medicine that represents, hot malicious essence is except containing multiple pathogenic microorganisms, and microbial toxin also accounts for critical positions.Honeysuckle preparation lumbar injection can obviously reduce the leukocyte count of rabbit due to the endotoxin of Pseudomonas aeruginosa and decline, and deviation to the left phenomenon etc. has obvious antagonism.The honeysuckle compatibility root of large-flowered skullcap is prepared into poisoning symptom and the death that preparation can obviously alleviate Pseudomonas aeruginosa endotoxin caused rabbit.
Peppermint:
[meridian distribution of property and flavor] is cool in nature, taste is pungent;
The effect of [function] anti-irritant causes tracheae to produce new secretion, and makes the mucus of stiff be easy to get rid of, thus have eliminate the phlegm, the effect of sterilization.
It is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, hot eyes, body heat, throat, the gum disease such as swell and ache.Place is with controlling neuralgia, pruitus, fash and eczema etc.The peppermint of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table in the Spring Festival.Clearly good to eat.Usually with peppermint for tea, improving eyesight clears away heart-fire.Peppermint has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, mouth disease, makes breath freshening.With mint tea juice, gargle, can be anti-halitosis in advance.With mint tea mist, steam face, also have the effect of shrinking pore.By the blade that steeped tea, apply and on eyes, can feel refrigerant, can remove eye fatigue.It is said that peppermint also has the another name of " eyes grass ", can be used for treating eye illness.
Orange peel:
Orange peel, gives out golden yellow clear bright pericarp, except fragrant sour-sweet taste, also has one simple and elegant flowery odour, can promote appetite, skin maintenance, minimizing sense of fatigue.Sweet strongly fragrant fruital is applicable to drinking together with other flowers and plants very much.
One of fruit that citrus is nutritious and consumption figure is maximum.Pulp flavor is splendid, and juice sweet taste is beautiful, also often makes popular drink.After orange peel processing, can be made into candy and jelly etc., is the traditional Chinese medical science conventional " dried orange peel " after drying; Blade, flower and fruit can refine essential oil, perfume.Pomace and pericarp also can obtain through refining pectin and aromatic oil brews up with orange peel, can utilize that orange peel is regulated the flow of vital energy in wide, the effect of stopping coughing and removing phlegm, and orange peel bubble green tea, can reduce phlegm and internal heat and separate phlegm, anti-inflammation, therefore cough ant phlegm person drink is useful.
Moutan bark: tree peony not only has ornamental value, but also there is very high medical value.The root of tree peony is processed into " root bark of tree peony ", is famous and precious Chinese herbal medicine.Its cold nature, taste is pungent, nontoxic, enters the heart, liver, kidney three warps, has loose hemostasis, purifies the blood and blood, pain relieving, the effect of stimulating the menstrual flow, and reduces blood pressure in addition, the effect of anti-inflammation, and clothes can be lengthened the life by beneficial body for a long time.Nourish blood and liver, the loose strongly fragrant stasis of blood of dispelling, be applicable to chloasma faciei, skin senescence, often drinks the qi and blood lung of living, and appearance is ruddy, improves menstrual disorder, dysmenorrhoea, abnormal sweating only, night sweat.
Chinese tuliptree bark:
[nature and flavor] are pungent; Warm in nature
[function cures mainly] dispels rheumatism; Loose cold cough-relieving.Main air pain of dampness syndrome; Cough due to wind-cold evil
[usage and dosage] is for oral administration: decoct soup, 9～15g.
[1]
Pharmacological action
Antibacterial action heartwood ethanol extract has antibacterial action, effective to staphylococcus aureus, smegma mycobacterium, Candida albicans and aspergillus niger etc., further proves that antibiotic effective ingredient is dehydroglaucin (dehydroglaucine).
Denseflower indigo leaf:
[meridian distribution of property and flavor] taste is pungent; Bitter; Warm in nature.
[function cures mainly] desinsection; The antipruritic ringworm of the foot; Scabies.
Lappula echinata:
[meridian distribution of property and flavor] toil, flat, poisonous.1. < < Tang materia medica > >: " bitter, flat, slightly poisonous." 2. < < detailed outline > >: " and toil, slightly poisonous." 3. < < medical center bun want > >: " toil, temperature." enter spleen, stomach, Liver Channel; < < herbal classic is met former > >, and " " cloudy Liver Channel enters to faint.”
[effect] desinsection, clearing heat and detoxicating, strengthening the spleen and stomach.
[curing mainly] controls abdominal pain due to enterositosis, Trichomonas vaginalis; It has anthelmintic action, and 1% Lappula echinata is joined in 5 dropping human physiology saline solution 25ml, the 37℃Zai Fang National People's Congress tapeworm of heating, and result 1-2 minute is dead.
Grassleaf sweetflag leaf:
[nature and flavor] are pungent, temperature enters the heart, lung two warps.
[function cures mainly] detoxification sore treatment, desinsection.Control sore scabies, leprosy, impetigo.
embodiment:
Embodiment 1, formula: described azedarach 50g, described camphortree leaf 30g, described myrrh 15g, described climbing groundsel 15g, described Lygodium japonicum 15g, described goldenrod 10g, described frankincense 20g, described honeysuckle 10g, described peppermint 10g, described orange peel 20g, described moutan bark 10g, described Chinese tuliptree bark 20g, described dandelion 20g, described denseflower indigo leaf 20g, described Lappula echinata 10g and described grassleaf sweetflag leaf 15g.
Preparation process is as follows:
The first step, packs azedarach, myrrh, Lappula echinata, orange peel, moutan bark, Chinese tuliptree bark in multi-function extractor into, adds alcohol heating reflux to extract, merge extract, centrifugal, filter, obtain filtered fluid, reduced pressure concentration reclaims ethanol, obtain medicinal extract, by medicinal extract stored refrigerated, enter subsequently in spray dryer dry, with cracker, pulverize and sieve, obtaining granularity is 50～100 object powder;
Second step, will remain herbal raw material difference boiling 2～4 times, merge decoction liquor separately, filter, and static spending the night, extracts the upper strata stillness of night, and reduced pressure concentration, except anhydrating, is dried to respectively dry cream, pulverize and will sieve, acquisition 70～120 order powder;
The 3rd step, will be above-mentioned during use powder drop in agitator and be stirred to evenly under normal temperature and pressure conditions, be added to and in warm water, obtain described disinfection of Chinese drug medicine.
The pig house of cleaning out and pig, can be used medicine of the present invention directly to spray, rinse or spread upon on pig house and porcine skin, and not only sterilizing, prevent disease, also have the effect repelling mosquitoes and flies with deodorizing.
Wherein, the ratio of described medicine and warm water is 1:10.
As preferably, in described medicine, can also add acetic acid ratio is 1:10.
As preferably, in described medicine, can also add sulphanilamide crystal powder 10g.
The acute toxicity experience of embodiments of the invention 1 medicine to mouse
1. experimental animal
The healthy KM mouse of SPF level, 30, male and female half and half, body weight 20-25g; Purchased from Shandong Province scientific tcm institute Experimental Animal Center
2. detect reagent serum AST, ALT detection kit purchased from Beijing Zhong Sheng company
3. checkout equipment
Micro-200 semiautomatic biochemistry detector, analytical balance, disscting instrument, syringe, test tube etc.
4. test method
After the adaptability of 3 days are raised, be divided at random 5 groups (male and female half and half), every group each 10; Control group, 4 various dose groups (be only respectively 76mg/, only, only, 357.6mg/ only for 219.9mg/ for 152.1mg/).Mouse free choice feeding, drinking-water, in feeding process, change water every day, the next day change bedding and padding.Whole experimental period is 7 days.
5. testing index and method
(1) clinicing symptom observation: every day viewing test mouse the state of mind, diet situation, every day entry Mortality situation.
(2) pathological observation: cut open inspection for dead mouse and observe internal organ variation.
(3) growth indexes is observed: test mouse is carried out to routine weighing; Off-test, slaughters that mouse weighs in, the heavy organ index of internal organs measures: cut open inspection kunming mice, dirty, the spleen of coring, liver, kidney, testis, ovary, weigh, and calculates according to the following formula organ index: organ index=internal organs weight/body weight * 100.
(4) liver function changes observation: after off-test, slaughter mouse, take blood separation of serum, measure AST, ALT.
6. data processing: above data acquisition carries out analytic statistics with SPSS11.0.
Clinicing symptom observation
Experimental group mouse, the state of mind and diet are wanted, respond has no significantly abnormal to external world.Each organizes mouse morbidity and death condition as following table 1.
Table 1
Pathological observation: experimental group, mouse is cutd open after slaughtering to examine to observe to have no and observes the obvious pathological change of internal organs.
Growth indexes is observed: off-test, slaughter that mouse weighs in, internal organs weight analysis is in Table 2.
Table 2
Liver function changes to be observed
After off-test, slaughter mouse, take blood separation of serum, measure AST, ALT in Table 3.Result shows respectively to be organized data and normal healthy controls group to compare difference not remarkable, all in normal range (NR).
Table 3
Even if experimental results show that from above the present invention all has no adverse reaction for the animal drinking or eat medicine of the present invention by mistake by mistake.
Clinical trial
By 480 health pig (male and female half and half, body weight is between 150kg～200kg) be divided at random two groups, organizing I is that pig house is used disinfection apparatus and uses the control group after herbal sprinkling of the present invention, and group II is that pig house is used disinfection apparatus and the disinfection tool method that also use limes as a control group.
Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical number of days, every day 9:00 and observe pig symptom during 16:00, dead pig is weighed, anatomic observation pathological change, and perform detailed record, to test, carried out not dead pig being weighed, being dissected in ten days, and recorded pathology situation, after having tested, to testing disease/dead rate, carry out data statistics, sick pig rate=sick pig is counted ÷ pig sum.Concrete outcome is in Table 4.
Table 4
| ? | Pig number | Sick pig number | Sick pig rate % |
| Group I | 240 | 0 | 0 |
| Group II | 240 | 15 | 6.25% |
Embodiment 2, formula:
Described azedarach 60g, described camphortree leaf 35g, described myrrh 20g, described climbing groundsel 20g, described Lygodium japonicum 20g, described goldenrod 15g, described frankincense 25g, described honeysuckle 15g, described peppermint 15g, described orange peel 25g, described moutan bark 15g, described Chinese tuliptree bark 25g, described dandelion 25g, described denseflower indigo leaf 25g, described Lappula echinata 15g and described grassleaf sweetflag leaf 20g;
Preparation method's using method is identical with embodiment 1.
The acute toxicity experience of embodiments of the invention 2 medicines to mouse
Test method is identical with the test method of embodiment 1,
Even if experimental results show that the present invention all has no adverse reaction for the animal drinking or eat medicine of the present invention by mistake by mistake.
Clinical trial
By 480 health pig (male and female half and half, body weight is between 150kg～200kg) be divided at random two groups, organizing I is that pig house is used disinfection apparatus and uses the control group after herbal sprinkling of the present invention, and group II is that pig house is used disinfection apparatus and the disinfection tool method that also use limes as a control group.
Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical number of days, every day 9:00 and observe pig symptom during 16:00, dead pig is weighed, anatomic observation pathological change, and perform detailed record, to test, carried out not dead pig being weighed, being dissected in ten days, and recorded pathology situation, after having tested, to testing disease/dead rate, carry out data statistics, sick pig rate=sick pig is counted ÷ pig sum.Concrete outcome is in Table 5.
Table 5
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. the medicine of pig house sterilization use, it is characterized in that: be by azedarach, camphortree leaf, myrrh, climbing groundsel, Lygodium japonicum, goldenrod, frankincense, honeysuckle, peppermint, orange peel, moutan bark, Chinese tuliptree bark, dandelion, denseflower indigo leaf, Lappula echinata and grassleaf sweetflag leaf, amount to 16 taste Chinese medicinal herbses and form.
2. the medicine of a kind of pig house sterilization use according to claim 1, it is characterized in that: the ratio of weight and number of each component in described medicine is, described azedarach 50～60 weight portions, described camphortree leaf 30～35 weight portions, described myrrh 15～20 weight portions, described climbing groundsel 15～20 weight portions, described Lygodium japonicum 15～20 weight portions, described goldenrod 10～15 weight portions, described frankincense 20～25 weight portions, described honeysuckle 10～15 weight portions, described peppermint 10～15 weight portions, described orange peel 20～25 weight portions, described moutan bark 10～15 weight portions, described Chinese tuliptree bark 20～25 weight portions, described dandelion 20～25 weight portions, described denseflower indigo leaf 20～25 weight portions, described Lappula echinata 10～15 weight portions and described grassleaf sweetflag leaf 15～20 weight portions.
3. according to the medicine of a kind of pig house sterilization use described in claim 1 and 2 any one, be further characterized in that: medicine of the present invention is prepared from by the following method:
The first step, packs azedarach, myrrh, Lappula echinata, orange peel, moutan bark, Chinese tuliptree bark in multi-function extractor into, adds alcohol heating reflux to extract, merge extract, centrifugal, filter, obtain filtered fluid, reduced pressure concentration reclaims ethanol, obtain medicinal extract, by medicinal extract stored refrigerated, enter subsequently in spray dryer dry, with cracker, pulverize and sieve, obtaining granularity is 50～100 object powder;
Second step, will remain herbal raw material difference boiling 2～4 times, merge decoction liquor separately, filter, and static spending the night, extracts the upper strata stillness of night, and reduced pressure concentration, except anhydrating, is dried to respectively dry cream, pulverize and will sieve, acquisition 70～120 order powder;
The 3rd step, will be above-mentioned during use powder drop in agitator and be stirred to evenly under normal temperature and pressure conditions, be added to and in warm water, obtain described disinfection of Chinese drug medicine;
The pig house of cleaning out and pig, can be used medicine of the present invention directly to spray, rinse or spread upon on pig house and porcine skin, and not only sterilizing, prevent disease, also have the effect repelling mosquitoes and flies with deodorizing.
4. the medicine of a kind of pig house sterilization use according to claim 3, is characterized in that: the ratio of described medicine and warm water is 1:10.
5. according to the medicine of a kind of pig house sterilization use described in claim 1,2,3 any one, it is characterized in that: in described medicine, can also add acetic acid ratio is 1:10.
6. according to the medicine of a kind of pig house sterilization use described in claim 1,2,3 any one, it is characterized in that: in described medicine, can also add sulphanilamide crystal powder 10～15 weight portions.
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| CN104488532A (en) * | 2014-12-30 | 2015-04-08 | 广西乐业县顾式茶有限公司 | Method for space auxiliary sterilization of livestock houses by natural fragrance of grasses and flowers |
| CN105148309A (en) * | 2015-08-25 | 2015-12-16 | 郎溪县凌达养猪专业合作社 | Swine excrement deodorant containing Chinese herbal medicinal ingredients |
| CN105148307A (en) * | 2015-08-25 | 2015-12-16 | 郎溪县凌达养猪专业合作社 | Pig raising manure deodorization preparation |
| CN105211131A (en) * | 2015-08-25 | 2016-01-06 | 郎溪县凌达养猪专业合作社 | Pigsty sterilizing preparation |
| CN105660482A (en) * | 2016-02-26 | 2016-06-15 | 安徽天邦饲料科技有限公司 | Breeding method for increasing survival rate of yellow catfish fry |
| CN106035428A (en) * | 2016-05-26 | 2016-10-26 | 安徽禹王养殖有限公司 | Chinese herbal medicine sanitizer used in pig farm and preparing method thereof |
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| CN106342951A (en) * | 2016-08-28 | 2017-01-25 | 广西兴胜农牧有限公司 | Disinfectant special for pigpen |
| CN106342963A (en) * | 2016-08-28 | 2017-01-25 | 广西兴胜农牧有限公司 | Hog house disinfectant |
| CN106344942A (en) * | 2016-08-28 | 2017-01-25 | 广西兴胜农牧有限公司 | Hog house disinfecting method |
| CN106359282A (en) * | 2016-08-31 | 2017-02-01 | 李宏强 | Baby rex rabbit confined farming method |
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| CN109042348A (en) * | 2018-08-09 | 2018-12-21 | 广西辽大农业科技集团股份有限公司 | A kind of piggery system |
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| CN105148309A (en) * | 2015-08-25 | 2015-12-16 | 郎溪县凌达养猪专业合作社 | Swine excrement deodorant containing Chinese herbal medicinal ingredients |
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| CN106342963A (en) * | 2016-08-28 | 2017-01-25 | 广西兴胜农牧有限公司 | Hog house disinfectant |
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| CN106359282A (en) * | 2016-08-31 | 2017-02-01 | 李宏强 | Baby rex rabbit confined farming method |
| CN106857709A (en) * | 2017-03-14 | 2017-06-20 | 滁州新源农业科技有限公司 | One kind raises region pond bactericide and preparation method scattered for black pig |
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