CN114903956A

CN114903956A - Chinese herbal medicine composition for preventing and treating pig diseases and preparation method and application thereof

Info

Publication number: CN114903956A
Application number: CN202210844573.7A
Authority: CN
Inventors: 李水开; 崔厚祥; 李家钦; 赵一锋
Original assignee: Xinxing County Kunbao Biotechnology Co Ltd; Guangdong Provincial Institute Of Metrology (south China National Centre Of Metrology)
Current assignee: Xinxing County Kunbao Biotechnology Co Ltd; Guangdong Provincial Institute Of Metrology (south China National Centre Of Metrology)
Priority date: 2022-07-19
Filing date: 2022-07-19
Publication date: 2022-08-16

Abstract

The invention discloses a Chinese herbal medicine composition for preventing and treating pig diseases and a preparation method and application thereof; the Chinese herbal medicine composition comprises the following raw materials in parts by weight: 2-22 parts of honeysuckle, 4-25 parts of isatis root, 3-24 parts of reed rhizome, 1-19 parts of Chinese pulsatilla root, 3-20 parts of liquorice, 5-25 parts of amaranth, 8-30 parts of gelsemium elegans, 3-23 parts of heartleaf houttuynia herb and 3-25 parts of Chinese knotweed herb; the invention provides two preparation methods of the Chinese herbal medicine composition, one of which is as follows: pulverizing the above materials, extracting with ethanol or water to obtain extract, and spray drying to obtain Chinese medicinal composition; the second is as follows: pulverizing the above materials, sieving, and mixing to obtain Chinese medicinal composition; the Chinese herbal medicine composition can effectively prevent and treat African swine fever, and can also effectively prevent other common diseases of pigs.

Description

Chinese herbal medicine composition for preventing and treating pig diseases and preparation method and application thereof

Technical Field

The invention relates to the technical field of Chinese herbal medicines, in particular to a Chinese herbal medicine composition for preventing and treating pig diseases and a preparation method and application thereof.

Background

African Swine Fever (ASF) is an acute contact, extensive hemorrhagic and virulent infectious disease caused by African Swine Fever Virus (ASFV) infecting pigs, pigs of all ages are susceptible, the death rate after the disease is up to 100%, and the disease is listed as an animal epidemic disease reported by the world animal health Organization (OIE) in the law and is also a type of animal epidemic disease which is mainly prevented in China.

African swine fever is latent for 5-9 days and is characterized by high fever, cyanosis of the skin, severe bleeding of lymph nodes and internal organs. Once the pig is infected, the body temperature is suddenly raised to 40.5-42 ℃, other symptoms are not presented in 4-6 hours, high fever lasts for 4 days, and then depression, anorexia and general weakness appear only after the body temperature is lowered. Dysbasia, diarrhea, hematochezia, nostril bleeding, cyanotic areas of the skin of the ear and back, swelling and yellow skin are characteristic symptoms appearing earlier. Rapid heartbeat, rapid respiration, dyspnea in some pigs, cough, serous to mucous rhinorrhea and eye secretion. Some outbreaks die suddenly due to temperature drop in the later period of illness due to different strains, the African swine fever course lasts for 4-7 days, and the death rate is as high as 95% -100%.

ASF is a serious cross-regional infectious disease, which has high infectivity and pathogenicity, and the research and development of the vaccine for the African swine fever virus is a worldwide problem, so that at present, no African swine fever vaccine approved for sale and use in all countries including China exists; in the prior art, the prevention and control difficulty and pressure of a farm are huge, the farm can only eliminate and control the disease by means of strict prevention and control measures such as disinfection, isolation, extinguishment, innocent treatment and the like, and good prevention and control measures can reduce the invasion risk of the ASFV and play a certain role in preventing the ASFV; however, once a pig is infected with African swine fever, it is difficult to treat it effectively.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a Chinese herbal medicine composition for preventing and treating diseases of pigs as well as a preparation method and application thereof, wherein the Chinese herbal medicine composition is prepared from honeysuckle, radix isatidis, reed rhizome, Chinese pulsatilla root, liquorice, acalypha australis, gelsemium elegans, houttuynia cordata and Chinese knotweed herb; the Chinese herbal medicine composition can effectively prevent and treat African swine fever, and has the advantages of quick response, high cure rate and no side effect.

In order to achieve the purpose, the application provides a Chinese herbal medicine composition for preventing and treating pig diseases, which comprises the following raw materials in parts by weight:

2-22 parts of honeysuckle, 4-25 parts of isatis root, 3-24 parts of reed rhizome, 1-19 parts of Chinese pulsatilla root, 3-20 parts of liquorice, 5-25 parts of amaranth, 8-30 parts of gelsemium elegans, 3-23 parts of houttuynia cordata and 3-25 parts of Chinese knotweed herb.

As some possible implementation modes of the application, the composition comprises the following raw materials in parts by weight:

4-15 parts of honeysuckle, 6-15 parts of isatis root, 7-18 parts of reed rhizome, 6-13 parts of Chinese pulsatilla root, 5-14 parts of liquorice, 10-19 parts of amaranth, 12-28 parts of gelsemium elegans, 10-18 parts of houttuynia cordata and 10-18 parts of Chinese knotweed herb.

10-18 parts of honeysuckle, 8-18 parts of isatis root, 5-13 parts of reed rhizome, 8-12 parts of Chinese pulsatilla root, 10-15 parts of liquorice, 14-18 parts of amaranth, 10-25 parts of gelsemium elegans, 4-16 parts of houttuynia cordata and 4-16 parts of Chinese knotweed herb.

12-14 parts of honeysuckle, 10-13 parts of isatis root, 9-11 parts of reed rhizome, 9-11 parts of Chinese pulsatilla root, 11-12 parts of liquorice, 15-17 parts of amaranth, 15-23 parts of gelsemium elegans, 10-16 parts of houttuynia cordata and 11-15 parts of Chinese knotweed herb.

In addition, in order to achieve the above purpose, the invention also provides a preparation method of the Chinese herbal medicine composition for preventing and treating pig diseases, which comprises the following steps:

s1 pulverizing flos Lonicerae, radix Isatidis, rhizoma Phragmitis, radix Pulsatillae, radix Glycyrrhizae, herba Acalyphae, herba Gelsemii Elegantis, herba Houttuyniae, and herb Polygoni chinensis;

s2 extracting the pulverized flos Lonicerae, herba Houttuyniae, radix Isatidis, radix Glycyrrhizae, and herba Gelsemii Elegantis with water, and concentrating to obtain water extract; extracting rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with ethanol, and concentrating to obtain ethanol extract;

s3, respectively spray-drying the alcohol extract and the water extract and fully mixing to obtain the Chinese herbal medicine composition for preventing and treating the diseases of the pigs.

As some possible embodiments of the present application, the particle size of the herbal composition for preventing and treating swine diseases is not more than 50 microns.

As some possible embodiments of the present application, the preparation method of the water extract comprises: putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice, the gelsemium elegans and the Chinese knotweed into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3-5 times of water for reflux for 1-1.5h for the first time, adding 2-3 times of water for reflux for 1-1.5h for the second time; combining the two water extraction solutions, and concentrating to obtain the water extraction extract;

the preparation method of the alcohol extract comprises the following steps: reflux-extracting rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60-80% ethanol water solution twice, reflux-extracting with 3-4 times of ethanol water solution with the same concentration for 1-1.5 hr for the first time, reflux-extracting with 2-3 times of ethanol water solution with the same concentration for 1-1.5 hr for the second time, mixing the two ethanol extractive solutions, and concentrating to obtain the ethanol extract.

In addition, in order to achieve the above object, the present invention also provides a method for preparing the above Chinese herbal medicine composition, comprising the following steps: firstly, the honeysuckle, the radix isatidis, the reed rhizome, the Chinese pulsatilla root, the liquorice, the amaranth, the gelsemium elegans, the houttuynia cordata and the Chinese knotweed herb are crushed, then sieved by a sieve of 40-120 meshes and mixed, and the Chinese herbal medicine composition for preventing and treating the diseases of the pigs is obtained.

Based on the purpose, the invention also provides application of the Chinese herbal medicine composition for preventing and treating the pig diseases in preparation of the drug for preventing and treating the African swine fever.

As some possible embodiments of the application, the Chinese herbal medicine composition for preventing and treating the diseases of the pigs can also be used for preparing medicines for preventing and treating other common diseases of the pigs.

The invention has the beneficial effects that:

1. the invention reasonably carries out addition and subtraction compatibility according to the effects of 9 medicinal components of honeysuckle, isatis root, reed rhizome, Chinese pulsatilla root, liquorice, amaranth, gelsemium elegans, heartleaf houttuynia herb and Chinese knotweed, so that the medicinal materials supplement each other, and the Chinese herbal medicine composition prepared from 9 medicaments plays an extremely obvious effect in the aspect of preventing and treating African swine fever; the treatment data show that when the Chinese herbal medicine composition is applied to the treatment of African swine fever, the cure rate can reach 93.75 percent, and even if the Chinese herbal medicine composition is taken within 24 hours after the pig has the symptoms of the African swine fever, the cure rate can reach 100 percent; in addition, the Chinese herbal medicine composition can also effectively prevent common diseases of pigs such as blue ear disease, swine fever, foot and mouth disease, pseudorabies and the like; the prevention data show that when the Chinese herbal medicine composition is applied to preventing the blue-ear disease, the swine fever, the hoof blight, the pseudorabies and the African swine fever, the effective prevention rate can reach 100 percent, and the prevention data are carried out on the premise that the vaccination of any disease is not carried out on the pigs, and the epidemic prevention, the disinfection and the isolation are not carried out intentionally.

2. In the prior art, because the African swine fever is temporarily prevented and controlled without an effective vaccine, a farm can only rely on strict prevention and control measures such as disinfection, isolation, extinguishment, harmless treatment and the like to prevent and control the African swine fever, and the prevention and control needs to be carried out continuously for a long time, so that the prevention and control strength and the required material and material need higher cost, and once a pig is infected with the African swine fever, the treatment of the African swine fever is difficult to realize only through the prevention and control measures; the Chinese herbal medicine composition has few components, rich sources and low cost, can be prepared in a large scale and can be widely applied to prevention and control of African swine fever, and the prevention and control effect is far higher than the physical prevention and control such as killing; in addition, the Chinese herbal medicine composition has no toxic or side effect, and can only exert the health-care function on pigs and promote the growth of the pigs after being taken for a long time; the pig prevented and treated by the Chinese herbal medicine composition has good growth, smooth skin and hair, ruddy meat color and more delicious taste than other pork.

3. The invention provides two methods for preparing the Chinese herbal medicine composition, which are more flexible in actual production; the traditional Chinese medicine composition is prepared by an alcohol extraction and water extraction method, and the method can effectively improve the extraction rate of functional components in the Chinese herbal medicine, so that the effect of preventing and treating African swine fever is effectively improved; the two-way composition is prepared by a method of directly crushing and sieving, the method is simple and convenient, the mass production can be realized rapidly in the actual production, and the effect of preventing and treating African swine fever is also obvious by adjusting the dosage of the medicament.

Detailed Description

The technical solutions in the embodiments of the present application will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The African swine fever is an acute contact, widely hemorrhagic and virulent infectious disease, has extremely high pathogenicity to pigs of all ages, and has a mortality rate of up to 100 percent after the disease occurs, and the disease is an animal epidemic disease which is mainly prevented in China; at present, no African swine fever vaccine approved for sale in China exists in all countries including China; farms can only eliminate and control the disease by strict prevention and control measures such as disinfection, isolation, extinguishment and innocent treatment, absolute prevention cannot be realized, and once pigs only infect african swine fever, effective treatment is difficult.

Based on the above, the application provides a Chinese herbal medicine composition for preventing and treating diseases of pigs, which comprises the following components in parts by weight: 2-22 parts of honeysuckle, 4-25 parts of isatis root, 3-24 parts of reed rhizome, 1-19 parts of Chinese pulsatilla root, 3-20 parts of liquorice, 5-25 parts of amaranth, 8-30 parts of gelsemium elegans, 3-23 parts of houttuynia cordata and 3-25 parts of Chinese knotweed herb.

According to the invention, the addition and subtraction compatibility is reasonably carried out according to the effects of the honeysuckle, the isatis root, the reed rhizome, the Chinese pulsatilla root, the liquorice, the amaranthus spinosus, the gelsemium elegans and the houttuynia cordata, so that the medicinal materials complement each other, the African swine fever can be obviously prevented and treated, and meanwhile, other common pig diseases such as blue ear disease, hoof epidemic disease, swine fever, pseudorabies and the like can be effectively prevented; the composition has the advantages of few components, easy acquisition and no toxic or side effect on pigs.

The main transmission route of the African swine fever is that healthy pigs are directly contacted with sick pigs or pollutants, and the possibility of infecting the African swine fever is also existed when the pigs are bitten by vector insects such as poisonous ticks and the like. The pathogenesis of the virus is that the virus can enter a pig body through the mouth and an upper respiratory tract system, the infection occurs in a nasopharynx part or a tonsil, and the virus quickly spreads to a mandibular lymph node and spreads to the whole body through lymph and blood. Cells change rapidly in virulent infection and die before a significant stimulatory response is exhibited. In the case of a mild infection, the stimulation response is easily observed, the nucleus becomes large, and mitosis generally occurs. The symptoms are natural infection latency period of 5-9 days, which is often shorter, clinical experimental infection is 2-5 days, the body temperature is raised to 40.5-42 ℃ during onset of disease, the body temperature lasts for about four days until 48 hours before death, and the body temperature begins to drop. Rapid pulse, cough, about one third of rapid respiration, dyspnea, serous fluid or mucopurulent conjunctivitis, bloody diarrhea, vomiting and swine fever caused by some strains, and 50 percent of leucocyte reduction phenomenon is shown in three to five cases, the lymphocyte is also reduced, leucocyte anemia occurs when the body temperature is raised, the leucocyte number is not reduced until the leucocyte number is reduced to 40 percent on the fourth day, the immature leucocyte number is increased and can be observed, the leucocyte dies usually on the seventh day after fever, or the symptom dies only on one or two days.

Based on the comprehensive consideration of the characteristics of African swine fever and other common diseases of pigs, the basic principle of prevention and treatment of diseases in Chinese traditional medicine is that the diseases are prevented before first, the diseases are prevented, and both symptoms and root causes are treated, wherein the prevention before the diseases is the most ideal positive measure. The invention adopts the traditional Chinese medicine 'treating with poison' as the principle to carry out prevention and treatment, the traditional Chinese medicine 'treating with poison' is a method principle of the traditional Chinese medicine treatment, namely, the poison of the etiology of the disease is treated by adopting the poison drug with the opposite property to the poison drug to carry out the countercheck treatment and prevention. For example, the "plain questions, five major political treatises" are called: treat heat with cold and warm; treating cold with heat, cold and moving; treating the disease with warm nature and cold nature; it is indicated for clearing heat with warm nature. In addition, the earliest monograph in pharmacology, Shen nong Ben Cao Jing, explains the principle of treating diseases with toxic drugs in more detail. Nowadays, the therapy of "attacking poison with poison" has become a method of common attention in medical circles worldwide, and is widely applied, showing obvious curative effect and valuable value.

Based on the comprehensive consideration and the principle of 'combating poison with poison' therapy, the invention reasonably carries out addition and subtraction compatibility according to the effects of the components of gelsemium elegans, honeysuckle, isatis root, reed rhizome, Chinese pulsatilla root, amaranth, houttuynia cordata, Chinese knotweed and liquorice, so that the medicines complement each other, the African swine fever can be obviously prevented and treated, other common diseases of pigs can be effectively prevented, the components are few, the preparation is easy to obtain, and no toxic or side effect is caused to the pigs; in the formula, the gelsemium elegans has the effects of invigorating stomach, killing parasites and counteracting toxic substances; honeysuckle flower has the effects of clearing away heat and toxic materials and dispelling wind and heat; the components are monarch drugs; radix Isatidis, herba Acalyphae, and herb Polygoni chinensis have effects of clearing away heat and toxic materials, cooling blood, stopping bleeding, and resisting bacteria and inflammation as ministerial drugs; rhizoma phragmitis, the Chinese pulsatilla root and the heartleaf houttuynia herb are adjuvant drugs for clearing heat and removing toxicity, cooling blood and stopping dysentery, reducing swelling and expelling pus, and inducing diuresis and treating stranguria; the liquorice tonifies the spleen and qi, regulates the middle warmer and relieves urgency, harmonizes the medicines and relieves the toxicity and the intensity of the medicines, and is used as a guiding medicine; the medicines are used together, and have the effects of counteracting toxic substances, killing parasites, dissipating stagnation, clearing away heat and toxic materials, cooling blood, stopping dysentery, reducing swelling, promoting the production of body fluid, strengthening spleen and stomach, and achieving the purposes of strengthening body resistance, eliminating pathogenic factors and counteracting defense.

In the embodiments of the present application, the properties, taste, meridian tropism, functional indications, main ingredients and pharmacological actions of the components of the Chinese herbal medicine composition are as follows:

honeysuckle flower: sweet and cold in nature. Entering lung, heart and stomach meridians; has effects of clearing away heat and toxic materials, and dispelling pathogenic wind and heat; can be used for treating epidemic febrile disease, fever, wind-heat type common cold, cough due to lung heat, sore throat, heat toxin, dysentery with bloody stool, breast swelling and pain, carbuncle, and skin sore.

Radix isatidis: bitter and cold. Heart and stomach meridians entered; has effects of clearing away heat and toxic materials, cooling blood, and relieving sore throat; can be used for treating wind-heat type common cold, sore throat, warm toxic, macula, sore, and yellow toxic swelling.

Reed rhizome: sweet and cold in nature. Entering lung and stomach meridians; has effects in clearing away heat, promoting salivation, relieving vomit, and promoting urination; it can be used for treating thirst due to internal heat, pulmonary abscess, emesis due to stomach heat, stranguria due to heat, and odynuria.

The Chinese pulsatilla root: bitter and cold. Entering stomach and large intestine meridians; has effects of clearing away heat and toxic materials, cooling blood, and relieving dysentery; it is mainly used for treating heat-toxin bloody dysentery and damp-heat yellow intestine.

Licorice root: sweet and neutral. Entering heart, lung, spleen and stomach meridians; has the effects of invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, regulating the middle warmer and relieving urgency, removing toxic substance, harmonizing the effects of the above drugs, and relieving drug toxicity and toxicity; it can be used for treating weakness of spleen and stomach, asthenia, cough, asthma, sore throat, poisoning, and pyocutaneous disease.

The amaranth thorn is as follows: sweet, slightly bitter and cool in nature. Enter stomach, spleen and large intestine meridians; has effects in clearing away heat, promoting diuresis, removing toxic materials, relieving swelling, cooling blood, stopping bleeding, inhibiting bacteria, and relieving inflammation; it can be used for treating dysentery, enteritis, skin eczema, furuncle, and pyocutaneous disease.

Houttuynia cordata: pungent and slightly cold. Entering lung meridian; has effects of clearing away heat and toxic materials, relieving swelling, promoting pus discharge, inducing diuresis, and treating stranguria; it can be used for treating pulmonary abscess, intestinal jaundice, dysentery, acute mastitis, and stranguria with turbid urine.

Charcoal mother: sour, astringent and cool. It enters liver and large intestine meridians; has effects in clearing away heat and toxic materials, removing dampness, and relieving itching; it can be used for treating dysentery due to damp-heat and eczema.

Kiss: pungent, bitter and warm; has strong toxicity (less toxicity to cattle, sheep and pigs). The heart, lung and large intestine meridians entered; has effects of invigorating stomach, killing parasite, removing blood stasis, relieving pain, and removing toxic substances; can be used for treating dyspepsia, diarrhea, parasitic infestation, traumatic injury, eczema, scabies, skin ulcer, and toxic swelling. Modern researches show that the gelsemium elegans has the effects of resisting tumor, easing pain, enhancing immunity, promoting hematopoiesis and the like, and although the gelsemium elegans has low toxicity to pigs, the Chinese herbal medicine composition disclosed by the invention is used as a treatment medicine, also needs to be used as a prevention medicine and needs to be taken for a long time at random, so that the proportion of the Chinese herbal medicine composition is very important; according to the invention, the gelsemium elegans is combined with honeysuckle, radix isatidis, Chinese pulsatilla root, liquorice, acalypha australis, houttuynia cordata and Chinese knotweed herb which have a detoxifying function, and the proportion of the gelsemium elegans, the isatis root, the Chinese pulsatilla root, the liquorice, the acalypha australis, the houttuynia cordata and the Chinese knotweed herb is optimized, so that the prepared Chinese herbal medicine composition has no toxic or side effect on pigs, and has a remarkable effect on preventing and treating African swine fever.

In addition, the Chinese herbal medicine composition prepared according to the formula and the proportion can play a remarkable effect on preventing and treating African swine fever, and can also play a prevention effect on common diseases of pigs, such as blue ear disease, swine fever, pseudorabies and foot and mouth disease.

In order to improve the prevention and treatment effect of the Chinese herbal medicine composition on the African swine fever, as some possible embodiments of the application, the use amount of each component of the Chinese herbal medicine composition is further limited, namely the Chinese herbal medicine composition comprises the following components in parts by weight: 4-15 parts of honeysuckle, 6-15 parts of isatis root, 7-18 parts of reed rhizome, 6-13 parts of Chinese pulsatilla root, 5-14 parts of liquorice, 10-19 parts of amaranth, 12-28 parts of gelsemium elegans, 10-18 parts of houttuynia cordata and 10-18 parts of Chinese knotweed herb.

In order to improve the prevention effect of the Chinese herbal medicine composition on swine fever, blue ear disease, pseudorabies, hoof blight and other common diseases of pigs, the dosage of each component of the Chinese herbal medicine composition is further limited as some possible implementation modes of the application, namely the Chinese herbal medicine composition comprises the following components in parts by weight:

In order to improve the prevention and treatment effect of the Chinese herbal medicine composition on African swine fever and the prevention effect on swine fever, blue ear disease, pseudorabies and hoof blight, as some possible embodiments of the application, the use amount of each component of the Chinese herbal medicine composition is further limited, namely the Chinese herbal medicine composition comprises the following components in parts by weight:

In practical application, the key point of the Chinese herbal medicine composition for exerting curative effect is related to the effective components in the Chinese herbal medicine composition, such as (R, S) -goitrin in isatis root, galuteolin in honeysuckle, pulsatilla saponin in pulsatilla, liquiritin and glycyrrhizic acid in liquorice, gelsemine and gelsemine in gelsemium, and the like, and the content of the effective components and the unrecited effective components directly determines the control capability of the Chinese herbal medicine composition.

Based on the above, the invention also provides a preparation method of the Chinese herbal medicine composition, which comprises the following steps:

s2 extracting pulverized flos Lonicerae, herba Houttuyniae, radix Isatidis, Glycyrrhrizae radix, and herba Gelsemii Elegantis with water, and concentrating to obtain water extract; extracting rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with ethanol, and concentrating to obtain ethanol extract;

s3 spray drying the ethanol extract and the water extract respectively and mixing thoroughly to obtain the Chinese herbal medicine composition.

The invention carries out physical and chemical analysis on the functional components of each medicine, finds a proper extraction method of the medicine, carries out water extraction on honeysuckle, houttuynia cordata, isatis root, liquorice, gelsemium elegans and Chinese knotweed herb, and carries out alcohol extraction on reed rhizome, Chinese pulsatilla root and amaranth, thereby greatly improving the extraction rate of the functional components in each component; meanwhile, in the extraction process, the detoxifying components in the honeysuckle, the houttuynia cordata and the isatis root can inhibit toxic components in the gelsemium elegans, and the toxic and side effects of the Chinese herbal medicine composition are reduced primarily.

In order to improve the prevention and treatment effect of the Chinese herbal medicine composition on African swine fever, as some possible embodiments of the present application, the particle size of the Chinese herbal medicine composition is further defined, and the particle size of the Chinese herbal medicine composition is less than 50 microns. With the particle size, the absorption efficiency of pigs can be improved, and the prevention and treatment effect is improved.

In order to improve the prevention and treatment effect of the Chinese herbal medicine composition on African swine fever, as some possible embodiments of the application, the preparation method of the water extract and the alcohol extract is further defined, namely the preparation method of the water extract comprises the following steps: putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice and the Chinese knotweed into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3-5 times of water for reflux for 1-1.5h for the first time, and adding 2-3 times of water for reflux for 1-1.5h for the second time; combining the two water extraction solutions, and concentrating to obtain the water extraction extract; the preparation method of the alcohol extract comprises the following steps: reflux-extracting rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60-80% ethanol water solution twice, first refluxing with 3-4 times of ethanol water solution with the same concentration for 1-1.5 hr, and second refluxing with 2-3 times of ethanol water solution with the same concentration for 1-1.5 hr; and combining the two ethanol extraction solutions, and concentrating to obtain the ethanol extract.

The crushed medicine components are extracted in an ultrasonic extraction tank, and under the special effects of ultrasonic cavitation, crushing and the like, histocytes of each medicine component are instantaneously generated in water or ethanol to collapse and break, so that the water or the ethanol can permeate into the cells, the functional components in the cells are dissolved in the water or the ethanol, the dissolution of the functional components in the isatis root (R, S) -goitrin, the luteolin in the honeysuckle, the pulsatilla saponin in the pulsatilla, the liquiritin, the glycyrrhizic acid in the liquorice, the gelsemine and the like is promoted, the extraction rate of the functional components is improved, and the effect of the Chinese herbal medicine composition on the prevention and treatment of African swine fever is improved.

The above method is relatively complicated in practical use, and in order to achieve rapid and large-scale preparation of the Chinese herbal composition, the present application also provides another preparation method of the Chinese herbal composition as described above:

firstly, the honeysuckle, the radix isatidis, the reed rhizome, the Chinese pulsatilla root, the liquorice, the amaranth, the gelsemium elegans, the houttuynia cordata and the Chinese knotweed herb are crushed, then sieved by a sieve of 40-120 meshes and mixed, and the Chinese herbal medicine composition for preventing and treating the diseases of the pigs is obtained.

The preparation of the herbal composition of the present application is described in more detail below with reference to specific embodiments.

Example 1

S1 pulverizing flos Lonicerae 20 parts, radix Isatidis 4 parts, rhizoma Phragmitis 20 parts, radix Pulsatillae 3 parts, radix Glycyrrhizae 19 parts, herba Acalyphae 5 parts, herba Gelsemii Elegantis 28 parts, herba Houttuyniae 3 parts, and herb Polygoni chinensis 3 parts respectively;

s2, putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice, the gelsemium elegans and the Chinese knotweed into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 4 times of water for the first time and refluxing for 1.5 hours, and adding 3 times of water for the second time and refluxing for 1 hour; mixing the two water extractive solutions, and concentrating to obtain water extract; reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60% ethanol water solution twice, first with 4 times of 60% ethanol water solution, refluxing for 1 hr, and second with 3 times of 60% ethanol water solution, refluxing for 1.5 hr; mixing the two ethanol extractive solutions, and concentrating to obtain ethanol extract;

s3 spray drying the ethanol extract and the water extract respectively, mixing thoroughly, and making into powder with particle size not more than 50 μm to obtain the Chinese medicinal composition.

Example 2

S1 pulverizing flos Lonicerae 7 parts, radix Isatidis 15 parts, rhizoma Phragmitis 9 parts, radix Pulsatillae 13 parts, radix Glycyrrhizae 6 parts, herba Acalyphae 12 parts, herba Gelsemii Elegantis 25 parts, herba Houttuyniae 15 parts, and herb Polygoni chinensis 15 parts respectively;

s2, putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice, the gelsemium elegans and the Chinese knotweed into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3 times of water for reflux for 1 hour for the first time, adding 2 times of water for reflux for 1.5 hours for the second time; mixing the two water extractive solutions, and concentrating to obtain water extract; reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60% ethanol water solution twice, first with 3 times of 60% ethanol water solution, refluxing for 1.5 hr, and second with 2 times of 60% ethanol water solution, refluxing for 1.5 hr; mixing the two ethanol extractive solutions, and concentrating to obtain ethanol extract;

s3 spray drying the ethanol extract and the water extract respectively, mixing thoroughly, and making into powder with particle size not more than 50 μm to obtain the Chinese herbal composition.

Example 3

S1 pulverizing flos Lonicerae 10 parts, radix Isatidis 17 parts, rhizoma Phragmitis 13 parts, radix Pulsatillae 8 parts, radix Glycyrrhizae 15 parts, herba Acalyphae 14 parts, herba Gelsemii Elegantis 20 parts, herba Houttuyniae 16 parts, and herb Polygoni chinensis 5 parts respectively;

s2, putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice and the gelsemium elegans into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 4 times of water for reflux for 1 hour for the first time, adding 2.5 times of water for reflux for 1.5 hours for the second time; mixing the two water extractive solutions, and concentrating to obtain water extract; reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60% ethanol water solution twice, first with 3 times of 60% ethanol water solution, refluxing for 1.5 hr, and second with 2 times of 60% ethanol water solution, refluxing for 1.5 hr; mixing the two ethanol extractive solutions, and concentrating to obtain ethanol extract;

Example 4

S1 pulverizing flos Lonicerae 14 parts, radix Isatidis 10 parts, rhizoma Phragmitis 10 parts, radix Pulsatillae 11 parts, radix Glycyrrhizae 12 parts, herba Acalyphae 15 parts, herba Gelsemii Elegantis 19 parts, herba Houttuyniae 13 parts, and herb Polygoni chinensis 12 parts respectively;

s2, putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice and the gelsemium elegans into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3.5 times of water for the first time, refluxing for 1 hour, adding 2.5 times of water for the second time, and refluxing for 1 hour; mixing the two water extractive solutions, and concentrating to obtain water extract; reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60% ethanol water solution twice, first with 4 times of 60% ethanol water solution, refluxing for 1.5 hr, and second with 2 times of 60% ethanol water solution, refluxing for 1 hr; mixing the two ethanol extractive solutions, and concentrating to obtain ethanol extract;

Example 5

Firstly, 14 parts of honeysuckle, 10 parts of isatis root, 10 parts of reed rhizome, 11 parts of Chinese pulsatilla root, 12 parts of liquorice, 15 parts of amaranth, 19 parts of gelsemium elegans, 13 parts of houttuynia cordata and 12 parts of Chinese knotweed herb are respectively crushed, then the crushed raw materials are respectively sieved by a 100-mesh sieve, and the sieved raw materials are fully mixed to obtain the Chinese herbal medicine composition.

Comparative example 1

Compared with the embodiment 4, the proportion of the 9 medicines is changed, and the specific change is as follows: 1 part of honeysuckle, 18 parts of isatis root, 40 parts of reed rhizome, 3 parts of Chinese pulsatilla root, 19 parts of liquorice, 60 parts of amaranth, 25 parts of gelsemium elegans, 15 parts of heartleaf houttuynia herb and 12 parts of Chinese knotweed herb.

The rest of the steps and parameters were the same as in example 4.

Comparative example 2

S1 pulverizing flos Lonicerae 14 parts, radix Isatidis 10 parts, rhizoma Phragmitis 10 parts, radix Pulsatillae 11 parts, Glycyrrhrizae radix 12 parts, herba Acalyphae 15 parts, herba Houttuyniae 13 parts, and herb Polygoni chinensis 12 parts respectively;

s2, putting the crushed honeysuckle, the houttuynia cordata, the isatis root and the liquorice into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3.5 times of water for the first time, refluxing for 1 hour, adding 2.5 times of water for the second time, and refluxing for 1 hour; mixing the two water extractive solutions, and concentrating to obtain water extract; reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60% ethanol twice, first with 4 times of 60% ethanol water solution, refluxing for 1.5 hr, and second with 2 times of 60% ethanol water solution, refluxing for 1 hr; mixing the two ethanol extractive solutions, and concentrating to obtain ethanol extract;

Comparative example 3

S1 pulverizing flos Lonicerae 14 parts, radix Isatidis 10 parts, rhizoma Phragmitis 10 parts, radix Pulsatillae 11 parts, radix Glycyrrhizae 12 parts, herba Acalyphae 15 parts, rhizoma Atractylodis Macrocephalae 19 parts, herba Houttuyniae 13 parts, and herb Polygoni chinensis 12 parts respectively;

s2, putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice and the bighead atractylodes rhizome into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3.5 times of water for reflux for 1 hour for the first time, adding 2.5 times of water for reflux for 1 hour for the second time; mixing the two water extractive solutions, and concentrating to obtain water extract; reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60% ethanol water solution twice, first with 4 times of 60% ethanol water solution, refluxing for 1.5 hr, and second with 2 times of 60% ethanol water solution, refluxing for 1 hr; mixing the two ethanol extractive solutions, and concentrating to obtain ethanol extract;

Experimental example 1

Live pigs are cultured in a certain farm for more than 30 years, and the scale of the pigs in the farm is about 1000-; during the period of outbreak of common pig diseases such as blue ear disease, hoof blight, swine fever and African swine fever which occur in the farm in the past 30 years, the live pigs in the farm are generally three types, the first type of live pigs take the Chinese herbal medicine composition of any one of examples 1-5 and comparative examples 1-2 of the invention as a health care and prevention medicine daily, and the live pigs are not inoculated with any disease vaccine; the second type of live pigs do not take any health-care medicine, the prevention of common diseases of the pigs is carried out by means of vaccination, and the third type of live pigs have not been inoculated with relevant preventive vaccines of the diseases in the disease period and do not take any health-care medicine in daily life; the infection rates of the pigs during the period of the above-mentioned several common diseases in the farm are shown in Table 1.

Wherein, the infection rate = (number of pigs infected with a certain disease after taking a certain drug/total number of pigs taking a certain drug) × 100%; in addition, the infection rates in Table 1 are the average values of the infection rates of individual diseases in several cases, since the number of times of onset of each disease is not less than 1 for 30 years.

Wherein, the administration mode of the Chinese herbal medicine composition in the examples 1 to 4 as the preventive medicine is as follows: adding the Chinese herbal medicine composition into drinking water and feed to be mixed into wet mixture, wherein the mass ratio of the Chinese herbal medicine composition to the feed to the drinking water in the wet mixture is 30-40:50000: 75000; the Chinese herbal medicine composition is administrated once every 3-7 days, 2 meals each time, and each meal is ingested in the form of the wet mixture.

The administration of the herbal composition of example 5 as a prophylactic agent was as follows: adding the Chinese herbal medicine composition into drinking water and feed to be mixed into a wet mixture, wherein the mass ratio of the Chinese herbal medicine composition to the feed to the drinking water in the wet mixture is 150: 50000: 75000; the Chinese herbal medicine composition is administrated once every 3-7 days, 2 meals each time, and each meal is ingested by eating the wet mixture.

TABLE 1

From table 1 it can be seen that:

(1) in the prevention of African swine fever: the recorded data of the African swine fever in the Table 1 are only the data during the outbreak of the African swine fever in 2018-2019, and the African swine fever infection phenomenon does not appear in the rest of the years. During the outbreak of the African swine fever, the African swine fever virus appears in the farm, the infection rate of the daily pigs taking the Chinese herbal medicine composition in the embodiment 1-5 as a health-care medicine is relatively low, the infection rate is up to 16 percent, namely the lowest effective prevention rate (the effective prevention rate =100 percent to the infection rate) of the Chinese herbal medicine composition on the pigs is 84 percent; even in the daily pigs taking the herbal composition of examples 4 and 5 as a health care medicine, one pig does not have infection, namely the effective prevention rate of the herbal composition of examples 4 and 5 on African swine fever is 100%; while the pigs of the second, third and comparative examples 1 and 2 in the first category were only rapidly infected during the outbreak of african swine fever and died extensively; it is worth mentioning that although the second type of live pigs are vaccinated against diseases other than african swine fever, it is difficult for vaccines against other diseases to effectively prevent african swine fever; in addition, although the preparation method of the Chinese herbal medicine composition in the embodiment 5 is different from that of the embodiment 4, the control of the African swine fever can still be obviously realized by adjusting the dosage of the pigs;

(2) in the prevention of other diseases: the Chinese herbal medicine composition of examples 1-5 had a minimum effective prevention rate of 65% in terms of blue ear disease, 65% in terms of swine fever, 73.5% in terms of pseudorabies, and 67% in terms of foot and mouth disease; the effective prevention rate of the Chinese herbal medicine composition in the example 3 on the blue ear disease, the swine fever, the pseudorabies and the hoof blight is higher than that in the examples 1-2 and is equivalent to that of the vaccine, while the effective prevention rate of the Chinese herbal medicine composition in the examples 4 and 5 on the blue ear disease, the swine fever, the pseudorabies and the hoof blight is up to 100 percent, namely, the Chinese herbal medicine composition in the examples 4 and 5 is taken as a live pig for daily health care during the last 30 years, and one end of the live pig is not infected with the hoof blight, the blue ear disease, the swine fever and the pseudorabies; the Chinese herbal medicine compositions in the comparative examples 1 and 2 are not prepared according to the optimal formula and the optimal proportion in the invention, so that the capability of preventing the common diseases of the pigs is obviously reduced; it should be noted that although the herbal composition in example 5 is different from the preparation method in example 4, the prevention of common diseases in pigs can still be significantly achieved by adjusting the administration amount of pigs.

To sum up: the Chinese herbal medicine composition has good prevention effect on African swine fever, blue ear disease, swine fever and hoof blight; wherein, the Chinese herbal medicine composition in the embodiment 1-5 has better prevention effect on African swine fever; compared with the Chinese herbal medicine composition in the embodiment 1-2, the Chinese herbal medicine composition in the embodiment 3 has better prevention effect on the aspects of foot-and-mouth disease, blue ear disease, pseudorabies and swine fever; compared with the Chinese herbal medicine compositions in the examples 1-3, the Chinese herbal medicine composition in the examples 4 and 5 has the best prevention effect on the foot-and-mouth disease, the blue ear disease, the pseudorabies, the swine fever and the African swine fever, and the prevention effect can reach 100 percent.

In addition, in the half month before the application of the invention, the farm discovers African swine fever virus, blue-ear disease virus and swine fever virus in the field environment through self-examination, and then the serum of the pigs given the Chinese herbal medicine composition is subjected to spot examination, and the detection reports are shown in tables 2 to 5.

TABLE 2 hog cholera antibody assay report

TABLE 3 Porcine Reproductive and Respiratory Syndrome (PRRS) antibody detection report

TABLE 4 African swine fever virus nucleic acid detection report

TABLE 5 African swine fever virus antibody detection report

As can be seen from tables 2-5, the selective examination of pigs does not show related viral infection, and further shows that the Chinese herbal medicine composition has extremely remarkable effect in preventing African swine fever and common diseases of pigs.

Experimental example 2

In a pig farm about 500 m away from the farm in the experimental example 1, in 2018 and 2019, 33 pigs only have infection symptoms of African swine fever, such as high fever, dyspnea, cough, rhinorrhea, unstable walking, cyanosis of skin, swelling, mental depression, anorexia and the like, and the African swine fever virus exists in the pig farm proved by test paper; immediately isolating the 33 pigs by breeders, dividing the pigs into 2 groups, wherein the first group is 10 pigs, injecting cooling medicines into the horses, killing the pigs for 6 pigs after 2 days, and killing all pigs after four days; the second group is 23 pigs treated with the herbal composition of example 4 only, once a day during the treatment period; after the administration for 3 days, about 80 percent of the pigs have no disease deterioration, and the symptoms of the rest pigs with diseases are relieved; after 7 days of administration, about 80% of sick pigs have relieved symptoms, and the rest pigs have no obvious diseases; after 10 days of administration, all symptoms of sick pigs are resolved or no obvious African swine fever symptom is seen, the medicine is administered once every 3 days, after 10 days of administration, the mental states of 18 pigs are completely recovered, and the pigs are healthy, smooth in fur and ruddy in meat color; then daily prevention and health care are carried out on the pigs by the Chinese herbal medicine composition in the embodiment 4, during the prevention and health care period, the Chinese herbal medicine composition is administrated once every 3-7 days, and finally all infected pigs are cured; when the cured live pig grows up and is slaughtered, the taste of the pig is not different from that of a normal pig, and even the taste is better; in addition, after isolation of 33 pigs, the prevention period in which the herbal composition of example 4 was administered to 62 uninfected pigs in the equine was first 10 days per day, 10 days later, 3-7 days later, and finally, no African swine fever was infected to any one pig.

The experimental examples prove that the Chinese herbal medicine composition has extremely remarkable effect on preventing and treating swine fever.

Experimental example 3

When the medicine is specifically administered, the 252 sick pigs are randomly divided into 8 groups and are respectively treated by the Chinese herbal medicine compositions in examples 1-5 and comparative examples 1-3, the administration is carried out 1 time per day, the administration is changed to once every 3 days after 12 days of continuous administration, the preventive administration is started after 15 days, and the administration is carried out once every 3-7 days during the preventive administration. The cure rates of the sick pigs in each group are shown in table 6.

Wherein, the cure rate = (number of cured pigs per group/total number of pigs per group) × 100%.

TABLE 6

Wherein: in experiments 2 and 3, the Chinese herbal medicine compositions in examples 1 to 4 and comparative examples 1 to 3 are added into drinking water and feed to be mixed into a wet mixture for eating during treatment or prevention, wherein the mass ratio of the Chinese herbal medicine composition to the feed to the drinking water is 45-60:50000:75000 during treatment, and 2 meals are taken each time; for prevention, the mass ratio of the Chinese herbal medicine composition, the feed and the drinking water is 30-40:50000:75000, and 2 meals are taken each time; in the treatment or prevention of the Chinese herbal medicine composition in the embodiment 5, the Chinese herbal medicine composition is added into drinking water and feed to be mixed into a wet mixture for eating, wherein in the treatment, the mass ratio of the Chinese herbal medicine composition to the feed to the drinking water is 225-300:50000:75000, and 2 meals are taken each time; during prevention, the mass ratio of the Chinese herbal medicine composition, the feed and the drinking water is 150-.

As can be seen from table 6: the Chinese herbal medicine composition prepared by adopting the formula and the proportion and the two preparation methods provided by the invention has an extremely obvious effect on treating African swine fever, the cure rate is as high as 93.75%, while the effect on treating African swine fever is not obvious in comparative example 1 without the proportion according to the invention, the effect on treating African swine fever is difficult to exert after gelsemium is removed in comparative example 2, gelsemium is changed into bighead atractylodes rhizome in comparative example 3, although both gelsemium and bighead atractylodes rhizome have the effect of tonifying spleen, the Chinese herbal medicine composition after gelsemium is changed into white still has no obvious effect on treating African swine fever, and the Chinese herbal medicine composition is derived from effective components in gelsemium, such as gelsemine, gelsemine and the like, and the gelsemium has the characteristic of toxic attack; in addition, in addition to table 6, other medicinal components in the farm are replaced by some traditional Chinese medicines with corresponding effects, and the results show that the treatment effect of the farm is far inferior to that of the traditional Chinese medicine composition, even the farm has no treatment effect at all; it can be seen from comparative examples 2 and 3 that the 9 medicines in the invention can exert effects rather than simple replacement of medicines after being combined, and show uniqueness of medicine selection, and further show that the Chinese herbal medicine composition prepared according to the formula, the proportion and the preparation method in the invention has extremely remarkable effects in treating African swine fever. It should be noted that 7 sows out of the pigs cured in examples 1 to 5 were not only healthy but also normal born.

The comparison between experiment example 2 and experiment example 3 shows that: in the experimental example 2, the cure rate of the Chinese herbal medicine composition in the example 4 is 100%, and the cure rate of the Chinese herbal medicine composition in the experimental example 3 is 93.75% at most, because the infected pigs in the experimental example 2 are short in infection time and are taken within 24 hours of disease discovery, and the treatment is timely, so that the cure rate of 100% can be achieved, while part of the pigs in the experimental example 3 only have relatively long African swine fever infected time, the time of administration is more than 24 hours, even if the time of administration is more than 72 hours, the internal organs of the part of pigs are seriously damaged, and the Chinese herbal medicine composition in the invention is difficult to cure in time; however, as long as the treatment time is appropriate, the Chinese herbal medicine composition has a remarkable effect of treating the African swine fever.

The foregoing is merely a preferred embodiment of the invention, it is to be understood that the invention is not limited to the forms disclosed herein, but is not intended to be exhaustive or to limit the invention to other embodiments, and to various other combinations, modifications, and environments and may be modified within the scope of the inventive concept as expressed herein, by the teachings or the skill or knowledge of the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. The Chinese herbal medicine composition for preventing and treating the diseases of the pigs is characterized by comprising the following raw materials in parts by weight:

2. The Chinese herbal medicine composition for preventing and treating pig diseases according to claim 1 is characterized by comprising the following raw materials in parts by weight:

3. The Chinese herbal medicine composition for preventing and treating pig diseases according to claim 1 is characterized by comprising the following raw materials in parts by weight:

4. The Chinese herbal medicine composition for preventing and treating pig diseases according to claim 1 is characterized by comprising the following raw materials in parts by weight:

12-14 parts of honeysuckle, 10-13 parts of isatis root, 9-11 parts of reed rhizome, 9-11 parts of Chinese pulsatilla root, 11-12 parts of liquorice, 15-17 parts of amaranth, 15-23 parts of gelsemium elegans, 10-16 parts of cordate houttuynia and 11-15 parts of Chinese knotweed.

5. A method of preparing a herbal composition for the prevention and treatment of swine diseases according to any one of claims 1 to 4, comprising the steps of:

s2 extracting pulverized flos Lonicerae, herba Houttuyniae, radix Isatidis, radix Glycyrrhizae, herba Gelsemii Elegantis, and herb Polygoni chinensis with water, and concentrating to obtain water extract; extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with ethanol, and concentrating to obtain ethanol extract;

6. The method for preparing a herbal composition for preventing and treating pig diseases according to claim 5, wherein the particle size of the herbal composition for preventing and treating pig diseases is not more than 50 μm.

7. The preparation method of the Chinese herbal medicine composition for preventing and treating the diseases of the pigs as claimed in claim 5, wherein the preparation method of the water extract comprises the following steps: putting the crushed honeysuckle, the houttuynia cordata, the isatis root, the liquorice, the gelsemium elegans and the Chinese knotweed into an ultrasonic multifunctional extraction tank for reflux water extraction twice, adding 3-5 times of water for reflux for 1-1.5h for the first time, adding 2-3 times of water for reflux for 1-1.5h for the second time; combining the two water extraction solutions, and concentrating to obtain the water extraction extract;

the preparation method of the alcohol extract comprises the following steps: reflux-extracting pulverized rhizoma Phragmitis, radix Pulsatillae, and herba Acalyphae with 60-80% ethanol water solution twice, reflux-extracting with 3-4 times of ethanol water solution with the same concentration for 1-1.5 hr for the first time, reflux-extracting with 2-3 times of ethanol water solution with the same concentration for 1-1.5 hr for the second time, mixing the two ethanol extractive solutions, and concentrating to obtain the ethanol extract.

8. A preparation method of the Chinese herbal medicine composition for preventing and treating the diseases of the pigs as claimed in any one of claims 1 to 4, characterized in that the honeysuckle, the radix isatidis, the reed rhizome, the Chinese pulsatilla root, the liquorice, the amaranth, the gelsemium elegans, the houttuynia cordata and the Chinese knotweed herb are firstly crushed, then screened by a 40-120 mesh sieve and mixed, so that the Chinese herbal medicine composition for preventing and treating the diseases of the pigs is obtained.

9. Use of a herbal composition according to any one of claims 1-4 in the preparation of a medicament for the treatment and prevention of African swine fever.

10. The use of the herbal composition for preventing and treating swine diseases according to claim 9, wherein the herbal composition can be further used for preparing a medicament for preventing and treating other common diseases of swine.