CN104983840A - Chinese medicine composition for treating rhinitis - Google Patents

Chinese medicine composition for treating rhinitis Download PDF

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CN104983840A
CN104983840A CN201510425594.5A CN201510425594A CN104983840A CN 104983840 A CN104983840 A CN 104983840A CN 201510425594 A CN201510425594 A CN 201510425594A CN 104983840 A CN104983840 A CN 104983840A
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radix
herba
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medicine composition
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江耀义
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Abstract

The invention discloses a Chinese medicine composition for treating the rhinitis. The Chinese medicine composition comprises, by weight, 10-20 parts of smoked plums, 10-15 parts of cocklebur fruits, 10-30 parts of radix astragali, 10-15 parts of magnolias, 5-10 parts of angelica roots, 5-10 parts of radix saposhnikoviae, 6-10 parts of fineleaf schizonepeta herbs, 4-8 parts of largehead atractylodes rhizomes, 4-8 parts of medicine terminalia fruits, 2-8 parts of radix bupleuri, 5-10 parts of mint, 2-5 parts of ephedra, 2-5 parts of asarum and 4-8 parts of Ligusticum chuanxiong Hort. The Chinese medicine composition has the obvious effects of dispelling wind, freeing the orifices, diminishing swelling, expelling pus, clearing heat, promoting diuresis, protecting the liver, releasing the lungs, resisting bacteria, diminishing inflammation, relieving cough, eliminating phlegm, tonifying the spleen for benefiting qi and enhancing the immunity.

Description

A kind of Chinese medicine composition for the treatment of rhinitis
Technical field
The invention belongs to medicine field, relate to a kind of Chinese medicine composition for the treatment of rhinitis.
Background technology
The inflammation of the bronchia mucosal that rhinitis and nasal cavity inflammatory diseases are virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause.The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, ooze out, hypertrophy, atrophy or necrosis etc.
1. viral infection
Viral infection is its primary cause of disease, or on the basis of viral infection secondary bacterial infection.There will be a known the virus of kind more than 100 and can cause primary disease, modal is rhinovirus, is secondly influenza and parainfluenza virus, adenovirus, coronavirus, Coxsackie virus and mucus and paramyxovirus etc.Virus disseminating mode mainly sucks through respiratory tract, is secondly enter body by contaminated body or food.
2. inherited genetic factors
Allergy family history person is had easily to suffer from this disease.Patient home personnel have asthma, urticaria or drug allergy history more.Claim this patient for atopic individuals in the past, produce the ability of IgE antibody in its body higher than normal person.But someone finds in recent years, twin with the sickness rate in general population without significant difference.
3. nasal mucosa susceptibility
The generation of susceptibility comes from the frequent stimulation of antigenic substance, but its susceptible degree then looks mastocyte in nasal mucosa, the quantity of basophilic granulocyte and the ability of release chemical mediator.Now confirm, in allergic rhinitis patients nasal mucosa, above-mentioned cell quantity is not only higher than normal person, and has the ability discharging more by force chemical mediator.
4. antigenic substance
The antigenic substance stimulating body to produce IgE antibody is called allergen.This allergenic substances enters nasal mucosa again, is just combined with corresponding IgE and causes allergy.The allergen of primary disease is caused to be divided into imbedibility and food two large classes by the mode that it enters human body.
(1) inhalant allergen 1. the not all plant pollen of pollen can cause disease, only have that those pollen amounts are large, tree and grass coverage is wide, allergenicity is strong, and just most possibly become allergen by the pollen that wind is propagated.Due to the difference of plantation varieties, the pollen that different regions have allergenicity is also different.2. fungus is extremely wide in distributed in nature, is mainly present in soil and corrupt Organic substance.Its mycelia and spore all have allergenicity, but stronger with spore.3. dermatophagoides pteronyssinus belongs to Arthropoda Aranea guiding principle.Adult size is generally 300 ~ 500 μm.Main parasitic is each corner in room, wherein with maximum in the dust at the places such as bedding, medicated pillow, spfa cushion.The limbs of the Excreta of demodicid mite, ovum, desquamation and its size degradation, all can become allergen.4. animal scurf animal skins bits are one of the strongest allergens.To susceptible individual, if contact with related animal for a long time, then can by sensitization.Even if if contact the scurf of very smallest number after sensitization again, also can sniffle be inspired.5. indoor dust is one of common allergens causing perennial rhinitis.
(2) eating property allergen refers to enter human body by digestive tract and cause the allergenic substances of sniffle.Its mode acting on nasal mucosa is very complicated, still very unclear so far.Milk, eggs, fish and shrimp, meat, fruit, even certain vegetable all can become allergen.
Current doctor trained in Western medicine mainly adopts the therapeutic schemes such as antibiotic bactericidal antiphlogistic, operation, laser, but radical cure difficulty, relapse rate is high, and side effect is large, and medical expense is high.Middle medical drugs treatment side effect is little, also has the effect for the treatment of both the principal and secondary aspects of a disease.Theoretical in conjunction with present Development of Chinese Medicine, from improving curative effect of medication, reducing the angle of side effect, its side effect is little, and safety is high, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of rhinitis and preparation method thereof, this Chinese medicine composition has significant expelling pathogenic wind and restoring the functions of orifices in face, detumescence and apocenosis, clearing away heat-damp and promoting diuresis, protects the liver lung qi dispersing, anti-inflammation, relieving cough and expelling phlegm, invigorating the spleen and replenishing QI, strengthens the effect of immunity.
The technical solution adopted in the present invention is as follows:
Treat a Chinese medicine composition for rhinitis, raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Radix Bupleuri 2 ~ 8 parts, Herba Menthae 5 ~ 10 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts.
The Chinese medicinal composition preparation of the above a kind for the treatment of of allergic rhinitis, raw material is preferably made up of the Chinese medicinal components of following weight portion: Fructus Mume 15 ~ 20 parts, Fructus Xanthii 12 ~ 15 parts, the Radix Astragali 15 ~ 30 parts, Flos Magnoliae 12 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 8 parts, Radix Saposhnikoviae 5 ~ 8 parts, Herba Schizonepetae 8 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Fructus Chebulae 4 ~ 6 parts, Radix Bupleuri 2 ~ 6 parts, Herba Menthae 5 ~ 8 parts, 2 ~ 4 parts, Herba Ephedrae, Herba Asari 2 ~ 4 parts, Flos Magnoliae 1 ~ 2 part, Rhizoma Chuanxiong 4 ~ 6 parts, Radix Saposhnikoviae 6 ~ 8 parts, the best is made up of the Chinese medicinal components of following weight portion: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 18 parts, Fructus Xanthii 15 parts, the Radix Astragali 20 parts, Flos Magnoliae 12 parts, the Radix Angelicae Dahuricae 7 parts, Radix Saposhnikoviae 6 parts, Herba Schizonepetae 8 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Chebulae 6 parts, Radix Bupleuri 4 parts, Herba Menthae 8 parts, 2 parts, Herba Ephedrae, Herba Asari 3 parts, Rhizoma Chuanxiong 6 parts.
Another object of the present invention is to provide above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition of rhinitis, comprises the following steps:
(1) get respectively by weight: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Radix Bupleuri 2 ~ 8 parts, Herba Menthae 5 ~ 10 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts, dry;
(2) by weigh up Radix Scutellariae, Fructus Xanthii, the Radix Astragali, Flos Magnoliae is cut into slices, and boiling water boils, and gets filtrate and is concentrated into the mastic that relative density is 1 ~ 2 times, regulates the ph value of mastic to be 2 ~ 3 for subsequent use;
(3) by load weighted Fructus Mume, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Fructus Chebulae, Radix Bupleuri, Herba Menthae, Herba Ephedrae, Herba Asari, Rhizoma Chuanxiong beats powder, and cross 40 ~ 50 mesh sieves, sterilizing, medicine adding ratio is the water boil of 1:10 ~ 15 and gets filtrate.
(4) mastic described in (2) is mixed homogeneously with the filtrate described in (3) and be get final product.
The above preparation method technique is simple, and can remain the effective ingredient in medical material completely, and the efficacy of a drug is lasting, and be convenient to take, mouthfeel is good.
The pharmaceutical characteristic of each raw material is as follows:
Fructus Mume: for chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.
Fructus Xanthii: dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving, for anemofrigid cold, nasal sinusitis, rheumatic arthralgia, the symptoms such as rubella pruritus.
The Radix Astragali: nature and flavor, tepor, sweet, there is invigorating the spleen and replenishing QI, the effects such as strengthening superficial resistance to stop perspiration.For deficiency of vital energy appearance solid cause often easy to catch cold, obstinate disease body is empty.
Flos Magnoliae: dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
The Radix Angelicae Dahuricae: dispel the wind, dampness, detumescence, pain relieving.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.
Radix Saposhnikoviae: for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus just, insufficiency of the spleen leading to overabundance of dampness.
Herba Schizonepetae: dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Induce sweat loose wind, rash, and disappear skin ulcer, hemostasis.For flu, measles is sent out smooth thoroughly, have blood in stool, metrorrhagia, epistaxis.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Fructus Chebulae: relieving diarrhea with astringents, astringing lung-QI and relieving cough, pathogenic fire reducing sore-throat relieving.
Radix Bupleuri: for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium.
Herba Menthae: Herba Menthae is Chinese conventional Chinese medicine, young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption.
Herba Ephedrae: it is warm in nature, acrid in the mouth, micro-hardship, have effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, can treat anemofrigid cold, the diseases such as edema due to wind pathogen edema, bronchial asthma of breathing with cough uncomfortable in chest.
Herba Asari: induce sweat cold expelling, wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Nature and flavor and Gui Jingxin, temperature.Return liver, gallbladder, pericardium channel.
The present invention is on the basis of Chinese medicine traditional theory, in conjunction with medication experience among the people, uses modern scientific theory formulated.In formula, the medicine such as the Rhizoma Atractylodis Macrocephalae, the Radix Astragali can play invigorating the spleen and replenishing QI, strengthens the effect of immunity; Adopt the effect of Fructus Mume, Fructus Chebulae's relieving cough and expelling phlegm, chronic cough of deficiency lung; The medicines such as the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, can expelling pathogenic wind and restoring the functions of orifices in face, the flu rhinitis that treatment insufficiency of lung-QI causes, and improves body immunity, alleviates the reaction of anaphylactogen and suppresses inflammatory reaction; The medicine such as Flos Magnoliae, Fructus Xanthii, increase the blood flow rate of nasal membrane, improve microcirculation, increase local nutrition, promote the quickly-healing of nose focus, do not restrain blood vessel over the course for the treatment of simultaneously, therefore can not occur due to paralysis smooth muscle and produce rebound vasodilation, cause the drawback of medicamentous rhinitis, and there is good anti-allergic effects; Adopt the symptom such as migraine, giddy that the Drug therapy such as Herba Asari, Rhizoma Chuanxiong rhinitis causes, the release of Herba Asari inflammation-inhibiting medium simultaneously and the hypertrophy of connective tissue, play the effect of antiinflammatory, thus make the proud alleviation of the disease of nasal obstruction, all medicines share, and fundamentally alleviate the misery of patients with rhinitis, accelerate to take a turn for the better, and eliminate focus, reduce the probability of recurrent exerbation.There is significant expelling pathogenic wind and restoring the functions of orifices in face, detumescence and apocenosis, clearing away heat-damp and promoting diuresis after Chinese medicine composition combination of the present invention, protect the liver lung qi dispersing, anti-inflammation, relieving cough and expelling phlegm, invigorating the spleen and replenishing QI, strengthen the effect of immunity.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
One, a kind of preparation method for the treatment of the Chinese medicine composition of rhinitis
1. EXPERIMENTAL DESIGN:
5 embodiment design parameters of this test refer to table 1.
Table 1 embodiment preparation parameter table
Embodiment Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5
Fructus Mume (part) 10 20 15 13 18
Fructus Xanthii (part) 10 15 11 12 13
The Radix Astragali (part) 10 30 20 15 25
Flos Magnoliae (part) 15 10 12 13 10
The Radix Angelicae Dahuricae (part) 5 10 8 9 10
Radix Saposhnikoviae (part) 5 10 8 6 10
Herba Schizonepetae (part) 6 10 8 7 10
The Rhizoma Atractylodis Macrocephalae (part) 4 8 6 5 7
Fructus Chebulae's (part) 4 8 6 5 7
Radix Bupleuri (part) 2 8 6 5 7
Herba Menthae (part) 5 10 6 8 10
Herba Ephedrae (part) 5 2 3 4 5
Herba Asari (part) 2 3 5 4 5
Rhizoma Chuanxiong (part) 4 8 6 7 8
2. operating procedure:
(1) take respectively by weight and get Fructus Mume, Fructus Xanthii, the Radix Astragali, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Fructus Chebulae, Radix Bupleuri, Herba Menthae, Herba Ephedrae, Herba Asari, Rhizoma Chuanxiong, cleans, dry;
(2) by weigh up Radix Scutellariae, Fructus Xanthii, the Radix Astragali, Flos Magnoliae is cut into slices, and boiling water boils, and gets filtrate and is concentrated into the mastic that relative density is 1 times, regulates the ph value of mastic to be 2 for subsequent use;
(3) by load weighted Fructus Mume, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Fructus Chebulae, Radix Bupleuri, Herba Menthae, Herba Ephedrae, Herba Asari, Flos Magnoliae, Rhizoma Chuanxiong, Radix Saposhnikoviae beat powder, and cross 50 mesh sieves, sterilizing, medicine adding ratio is the water boil of 1:10 and gets filtrate.
(4) mastic described in (2) is mixed homogeneously with the filtrate described in (3) and be get final product.
Two, clinical trial: (1) clinical data the present inventor in 2006 so far, carries out clinical observation treatment to 80 routine Allergic Rhinitis, wherein man 32 example, female 48 example, the age is between 18 ~ 72 years old.(2) Therapeutic Method
Oral, three times on the one, each 100 ~ 150ml, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 3 months, and severe case serve on 12 months and can fully recover.(3) curative effect determinate standard:
Cure: symptom all disappears; Main Physico-chemical tests index is normally.
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially; Main Physico-chemical tests index makes moderate progress.
Invalid: main Physico-chemical tests index is front unchanged with treatment.(4) clinical effectiveness clinical cure 62 example (77 .5%), effective 10 examples (12. 5%), effective 4 examples (5%), invalid 2 examples (2. 5%), total effective rate is 97. 5%.
Be below several model case:
Case 1 Huang, female, 42 years old, readme symptom: paroxysmal rhinocnesmus, sneeze, the often a large amount of water sample nasal mucus of outflow, cause headache and dizzy, degradation symptom under olfactory sensation.Take the embodiment of the present invention 1 sample, one day three times, a 100ml, serve on March, symptom obviously alleviates, after continuing to take 4 months, and transference cure.
Case 2 beam, man 21 years old, rhinostegnosis, uncomfortable in chest in bed, not easily fell asleep, and was attended by headache tinnitus, shed tears, hoarseness chronic cough readme evening, through observing, its nasal mucosa swelling, color is light red, thin white fur of tongue, thready and weak pulse and.Take the embodiment of the present invention 1 sample, three times on the one, a 150ml, serve on symptom on the 7th and obviously alleviate, then take 5 months, breathe and suitable, diet increase, transference cure, recovery from illness.

Claims (3)

1. treat a Chinese medicine composition for rhinitis, it is characterized in that: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Radix Bupleuri 2 ~ 8 parts, Herba Menthae 5 ~ 10 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts.
2. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 1, is characterized in that: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 15 ~ 20 parts, Fructus Xanthii 12 ~ 15 parts, the Radix Astragali 15 ~ 30 parts, Flos Magnoliae 12 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 8 parts, Radix Saposhnikoviae 5 ~ 8 parts, Herba Schizonepetae 8 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Fructus Chebulae 4 ~ 6 parts, Radix Bupleuri 2 ~ 6 parts, Herba Menthae 5 ~ 8 parts, 2 ~ 4 parts, Herba Ephedrae, Herba Asari 2 ~ 4 parts, Rhizoma Chuanxiong 4 ~ 6 parts.
3. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 1 or 2, is characterized in that: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 18 parts, Fructus Xanthii 15 parts, the Radix Astragali 20 parts, Flos Magnoliae 12 parts, the Radix Angelicae Dahuricae 7 parts, Radix Saposhnikoviae 6 parts, Herba Schizonepetae 8 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Chebulae 6 parts, Radix Bupleuri 4 parts, Herba Menthae 8 parts, 2 parts, Herba Ephedrae, Herba Asari 3 parts, Rhizoma Chuanxiong 6 parts.
CN201510425594.5A 2015-07-20 2015-07-20 Chinese medicine composition for treating rhinitis Pending CN104983840A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106265927A (en) * 2016-08-31 2017-01-04 吉林紫鑫药业股份有限公司 A kind of pharmaceutical composition for treating rhinitis and nasosinusitis and allergic rhinitis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264190A (en) * 2008-04-21 2008-09-17 北京中科仁和科技有限公司 Chinese medicinal composition treating allergic rhinitis and preparation thereof
CN103610788A (en) * 2013-11-13 2014-03-05 王震 Traditional Chinese medicine (TCM) for treating allergic rhinitis
CN104435104A (en) * 2013-09-22 2015-03-25 李少洋 Formula of traditional Chinese medicine for treating allergic rhinitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264190A (en) * 2008-04-21 2008-09-17 北京中科仁和科技有限公司 Chinese medicinal composition treating allergic rhinitis and preparation thereof
CN104435104A (en) * 2013-09-22 2015-03-25 李少洋 Formula of traditional Chinese medicine for treating allergic rhinitis
CN103610788A (en) * 2013-11-13 2014-03-05 王震 Traditional Chinese medicine (TCM) for treating allergic rhinitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106265927A (en) * 2016-08-31 2017-01-04 吉林紫鑫药业股份有限公司 A kind of pharmaceutical composition for treating rhinitis and nasosinusitis and allergic rhinitis

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