CN104998106A - Traditional Chinese medicine composition for treating allergic rhinitis - Google Patents
Traditional Chinese medicine composition for treating allergic rhinitis Download PDFInfo
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- CN104998106A CN104998106A CN201510424962.4A CN201510424962A CN104998106A CN 104998106 A CN104998106 A CN 104998106A CN 201510424962 A CN201510424962 A CN 201510424962A CN 104998106 A CN104998106 A CN 104998106A
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Abstract
The present invention discloses a traditional Chinese medicine (TCM) composition for treating the allergic rhinitis, which comprises the following TCM raw materials in weight part: 10-20 parts of dark plum, 10-15 parts of xanthium, 10-30 parts of radix astragali, 10-15 parts of lily magnolia, 5-10 parts of dahurian angelica root, 5-10 parts of Chinese parsnip root, 6-10 parts of catnip, 4-8 parts of bighead atractylodes rhizome, 4-8 parts of terminalia, 10-20 parts of herba lopatheri, 8-15 parts of rabdosia rubescens, 2-5 parts of ephedra stem, 2-5 parts of asarum herb and 4-8 parts of ligusticum chuanxiong hort. The above TCM composition is designed under the guidance of the traditional TCM theory, and is prepared by several common TCM components. The TCM composition is obvious in wind-dispelling, aperture-dredging, swelling-removing and pus-expelling effect. The TCM composition can defuse the allergy to realize the effects of strong radical treatment effect, uneasy recurrence after healing, simple preparation process, convenient administration, short course and fast effect.
Description
Technical field
The invention belongs to medicine field, relate to a kind of Chinese medicine composition for the treatment of of allergic rhinitis.
Background technology
Allergic rhinitis and allergic rhinitis, after referring to atopic individuals contact allergen, primarily of medium (mainly histamine) release of IgE mediation, and have the nasal mucosa non-infectious inflammatory disease that panimmunity competent cell and cytokine etc. participate in.Its essential condition occurred has 3: namely specific antigen causes the material of organism immune response; Atopic individuals and so-called individual variation, allergic constitution; Specific antigen and spy answer both type individualities to meet.Allergic rhinitis are global health problem, can cause numerous disease and disability.Allergic rhinitis is a kind of multi-factor disease being interacted by gene and environment and brought out, and its risk factor may be present in all age brackets.
The cause of disease is as follows: 1. inherited genetic factors, and allergic rhinitis patients has atopy body constitution, usually demonstrates familial aggregation, studies have found that some gene is associated with allergic rhinitis.2. allergen exposes, and allergen is inducing specific IgE antibody and the antigen reacted with it.Their multi-sources are in animal, plant, insecticide, fungus or occupational material.Its composition is protein or glycoprotein, and only a few is polysaccharide.Allergen is mainly divided into inhalant allergen and food-consuming structure.Inhalant allergen is the main cause of allergic rhinitis.Classical symptom mainly paroxysmal sneeze, clear water sample nasal mucus, nasal obstruction and the rhinocnesmus of clinical manifestation allergic rhinitis, part is with hyposmia.Diagnosis: more than 2 (containing 2) appear in the symptoms such as clinical symptoms sneeze, clear water sample tears, nasal obstruction, rhinocnesmus, every day Symptoms last or be accumulated at more than 1 hour.Can with the eye symptom such as ophthalmic pruritus, conjunctival congestion.The common nasal mucosa of sign is pale, edema, nasal cavity watery secretion.Skin prick test is positive, and/or Specificity IgE is positive, feasible nasal provocation test if desired.
At present, the curative effect of medication one being used for the treatment of allergic rhinitis is few, western medical treatment adopts immunosuppressant only, the medicine symptom management such as hormone, this kind of medicine of long-term a large amount of use easily causes untoward reaction more, easy recurrence, the shortcomings such as drug withdrawal difficulty, and Chinese medicine or the treatment of the combination of Chinese and Western medicine to this kind of disease have good curative effect.
Summary of the invention
The object of this invention is to provide Chinese medicine composition of a kind for the treatment of of allergic rhinitis and preparation method thereof, the present invention asks the object because of, treating both the principal and secondary aspects of a disease in line with curing the disease, by Overall View and the dialectical thought treated, fundamentally solve the origin cause of formation of allergic rhinitis, thus reach the object of thoroughly curing, cure rate is high, makes patient's livelihood restoration normal after healing.
The technical solution adopted in the present invention is as follows:
A Chinese medicine composition for treatment of allergic rhinitis, raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Herba Lophatheri 10 ~ 20 parts, Rabdosia rubescens 8 ~ 15 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts.
The Chinese medicinal composition preparation of the above a kind for the treatment of of allergic rhinitis, raw material is preferably made up of the Chinese medicinal components of following weight portion: Fructus Mume 15 ~ 20 parts, Fructus Xanthii 12 ~ 15 parts, the Radix Astragali 15 ~ 30 parts, Flos Magnoliae 12 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 8 parts, Radix Saposhnikoviae 5 ~ 8 parts, Herba Schizonepetae 8 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Fructus Chebulae 4 ~ 6 parts, Herba Lophatheri 15 ~ 20 parts, Rabdosia rubescens 10 ~ 15 parts, 2 ~ 4 parts, Herba Ephedrae, Herba Asari 2 ~ 4 parts, Flos Magnoliae 1 ~ 2 part, Rhizoma Chuanxiong 4 ~ 6 parts, Radix Saposhnikoviae 6 ~ 8 parts, the best is made up of the Chinese medicinal components of following weight portion: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 18 parts, Fructus Xanthii 15 parts, the Radix Astragali 20 parts, Flos Magnoliae 12 parts, the Radix Angelicae Dahuricae 7 parts, Radix Saposhnikoviae 6 parts, Herba Schizonepetae 8 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Chebulae 6 parts, Herba Lophatheri 15 parts, Rabdosia rubescens 12 parts, 2 parts, Herba Ephedrae, Herba Asari 3 parts, Rhizoma Chuanxiong 6 parts.
Another object of the present invention is to provide the preparation method of the Chinese medicine composition of above-mentioned a kind for the treatment of of allergic rhinitis, comprises the following steps:
(1) get respectively by weight: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Herba Lophatheri 10 ~ 20 parts, Rabdosia rubescens 8 ~ 15 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts, dry;
(2) Fructus Xanthii will weighed up, the Radix Astragali, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Fructus Chebulae, Herba Lophatheri, Rabdosia rubescens, medicine adding ratio is the soak by water 20 ~ 30 minutes of 1:10 ~ 15, gets filtrate, regulates the ph value of filtrate to be 1 ~ 2 for subsequent use;
(3) by load weighted Fructus Mume, Herba Ephedrae, Herba Asari, Rhizoma Chuanxiong beats powder, and cross 40 ~ 50 mesh sieves, sterilizing, medicine adding ratio is the water boil of 1:10 ~ 15 and gets filtrate;
(4) filtrate described in (2) is mixed with the filtrate described in (3), then decoct 10 minutes, to obtain final product.
The above preparation method technique is simple, and can remain the effective ingredient in medical material completely, and the efficacy of a drug is lasting, and be convenient to take, mouthfeel is good.
The pharmaceutical characteristic of each raw material is as follows:
Fructus Mume: for chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.
Fructus Xanthii: dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving, for anemofrigid cold, nasal sinusitis, rheumatic arthralgia, the symptoms such as rubella pruritus.
The Radix Astragali: nature and flavor, tepor, sweet, there is invigorating the spleen and replenishing QI, the effects such as strengthening superficial resistance to stop perspiration.For deficiency of vital energy appearance solid cause often easy to catch cold, obstinate disease body is empty.
Flos Magnoliae: dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
The Radix Angelicae Dahuricae: dispel the wind, dampness, detumescence, pain relieving.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.
Radix Saposhnikoviae: for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus just, insufficiency of the spleen leading to overabundance of dampness.
Herba Schizonepetae: dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Induce sweat loose wind, rash, and disappear skin ulcer, hemostasis.For flu, measles is sent out smooth thoroughly, have blood in stool, metrorrhagia, epistaxis.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Fructus Chebulae: relieving diarrhea with astringents, astringing lung-QI and relieving cough, pathogenic fire reducing sore-throat relieving.
Herba Lophatheri: there is clearing heat and relieving fidgetness, effect ten of inducing diuresis for treating stranguria syndrome cures mainly calentura excessive thirst, aphtha of the mouth and tongue, gingival swelling and pain, children's's night crying due to fright in infant, cough due to lung-heat, and gastric heat is vomitted the sound of vomiting, hot urination stranguria with turbid discharge, for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium.
Rabdosia rubescens: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.For laryngopharynx swelling and pain, lump in the abdomen mass in the abdomen, snake bite and insect sting.
Herba Menthae: Herba Menthae is Chinese conventional Chinese medicine, young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption.
Herba Ephedrae: it is warm in nature, acrid in the mouth, micro-hardship, have effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, can treat anemofrigid cold, the diseases such as edema due to wind pathogen edema, bronchial asthma of breathing with cough uncomfortable in chest.
Herba Asari: induce sweat cold expelling, wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Nature and flavor and Gui Jingxin, temperature.Return liver, gallbladder, pericardium channel.
The present invention is on the basis of Chinese medicine traditional theory, in conjunction with medication experience among the people, uses modern scientific theory formulated.In formula, Herba Lophatheri, Rabdosia rubescens etc. play heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, eliminate the effect of focus; The medicine such as the Rhizoma Atractylodis Macrocephalae, the Radix Astragali can play invigorating the spleen and replenishing QI, strengthens the effect of immunity; Adopt the effect of Fructus Mume, Fructus Chebulae's relieving cough and expelling phlegm, chronic cough of deficiency lung; The medicines such as the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, can expelling pathogenic wind and restoring the functions of orifices in face, the flu rhinitis that treatment insufficiency of lung-QI causes, and improves body immunity, alleviates the reaction of anaphylactogen and suppresses inflammatory reaction; The medicine such as Flos Magnoliae, Fructus Xanthii, increase the blood flow rate of nasal membrane, improve microcirculation, increase local nutrition, promote the quickly-healing of nose focus, do not restrain blood vessel over the course for the treatment of simultaneously, therefore can not occur due to paralysis smooth muscle and produce rebound vasodilation, cause the drawback of medicamentous rhinitis, and there is good anti-allergic effects; Adopt the symptom such as migraine, giddy that the Drug therapy such as Herba Asari, Rhizoma Chuanxiong rhinitis causes, the release of Herba Asari inflammation-inhibiting medium simultaneously and the hypertrophy of connective tissue, play the effect of antiinflammatory, thus make the proud alleviation of the disease of nasal obstruction, all medicines share, and fundamentally alleviate the misery of patients with rhinitis, accelerate to take a turn for the better, and eliminate focus, reduce the probability of recurrent exerbation.The present invention is traditionally guidance of traditional Chinese medicine theory, adopts common several Chinese crude drug formula to form and has significant expelling pathogenic wind and restoring the functions of orifices in face, the effect of detumescence and apocenosis, by dissolving allergy, reach radical cure dynamics strong, not easily recur more, preparation technology is simple, taking convenience, curative effect is short, instant effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
One, a kind of preparation method of Chinese medicine composition for the treatment of of allergic rhinitis
1. EXPERIMENTAL DESIGN:
The design parameter of 5 embodiments of this test refers to table 1.
Table 1 embodiment preparation parameter table
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Fructus Mume (part) | 10 | 20 | 15 | 13 | 18 |
| Fructus Xanthii (part) | 10 | 15 | 11 | 12 | 13 |
| The Radix Astragali (part) | 10 | 30 | 20 | 15 | 25 |
| Flos Magnoliae (part) | 15 | 10 | 12 | 13 | 10 |
| The Radix Angelicae Dahuricae (part) | 5 | 10 | 8 | 9 | 10 |
| Radix Saposhnikoviae (part) | 5 | 10 | 8 | 6 | 10 |
| Herba Schizonepetae (part) | 6 | 10 | 8 | 7 | 10 |
| The Rhizoma Atractylodis Macrocephalae (part) | 4 | 8 | 6 | 5 | 7 |
| Fructus Chebulae's (part) | 4 | 8 | 6 | 5 | 7 |
| Rabdosia rubescens (part) | 10 | 8 | 12 | 15 | 13 |
| Herba Lophatheri (part) | 15 | 10 | 20 | 12 | 13 |
| Herba Ephedrae (part) | 5 | 2 | 3 | 4 | 5 |
| Herba Asari (part) | 2 | 3 | 5 | 4 | 5 |
| Rhizoma Chuanxiong (part) | 4 | 8 | 6 | 7 | 8 |
2. operating procedure:
(1) get respectively by weight: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Herba Lophatheri 10 ~ 20 parts, Rabdosia rubescens 8 ~ 15 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts, dry;
(2) Fructus Xanthii will weighed up, the Radix Astragali, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Fructus Chebulae, Herba Lophatheri, Rabdosia rubescens, medicine adding ratio is the soak by water 20 ~ 30 minutes of 1:10 ~ 15, gets filtrate, regulates the ph value of filtrate to be 1 ~ 2 for subsequent use;
(3) by load weighted Fructus Mume, Herba Ephedrae, Herba Asari, Rhizoma Chuanxiong beats powder, and cross 40 ~ 50 mesh sieves, sterilizing, medicine adding ratio is the water boil of 1:10 ~ 15 and gets filtrate;
(4) filtrate described in (2) is mixed with the filtrate described in (3), then decoct 10 minutes, to obtain final product.
Two, clinical trial: (1) clinical data the present inventor in 2003 so far, carries out clinical observation treatment to 80 routine Allergic Rhinitis, wherein man 40 example, female 40 example, the age is between 13 ~ 45 years old.(2) Therapeutic Method
Oral, 3 times on the one, each 50ml ~ 150ml, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 3 months, and severe case serve on 8 months and can fully recover.(3) curative effect determinate standard:
Cure: symptom all disappears; Main Physico-chemical tests index is normally.
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially; Main Physico-chemical tests index makes moderate progress.
Invalid: main Physico-chemical tests index is front unchanged with treatment.(4) clinical effectiveness clinical cure 59 example (73.75%), effective 10 examples (12. 5%), effective 7 examples (8.75%), invalid 4 examples (5%), total effective rate is 95%.
Be below several model case:
Case 1 Huang, female, 30 years old, first visit in April, 2008, patient's readme: regular abdominal pain and distension lower abdomen tenesmus over nearly 3 years, sneeze is frequent sooner or later, and with slight headache.Be allergic rhinitis (adenoids) through city's hospital diagnosis, Chinese and western medicine multi-treatment is invalid and go to a doctor.Body is examined: wing of nose both sides place flushing, the micro-infantile malnutrition of lip.Inspection of the tongue: corpulent tongue has greasy coating greatly, dark tongue quality.Pulse-taking: both hands cun GUAN-pulse is tightly outstanding and slide, both hands CHI-pulse being weak.Take the embodiment of the present invention 2 sample, one day three times, a 100ml, serve on March, symptom obviously alleviates, after continuing to take 4 months, and transference cure.
Case 2 Liu, man, 43 years old, first visit in August, 2004, patient's readme: often occur that headache dizziness is weak over nearly 4 years, nasal obstruction, nose pain, cold, the headache of nose, the phenomenon such as to snore, sneeze took place frequently sooner or later.Take the embodiment of the present invention 3 sample, three times on the one, a 150ml, serve on sneeze, nasal obstruction, watery nasal discharge on the 7th and obviously reduce, symptom obviously alleviates, then takes 5 months, breathe and suitable, diet increase, transference cure, recovery from illness.Follow up a case by regular visits to 6 months, without recurrence.
Claims (3)
1. a Chinese medicine composition for treatment of allergic rhinitis, is characterized in that: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 10 ~ 20 parts, Fructus Xanthii 10 ~ 15 parts, the Radix Astragali 10 ~ 30 parts, Flos Magnoliae 10 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Herba Schizonepetae 6 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 8 parts, Fructus Chebulae 4 ~ 8 parts, Herba Lophatheri 10 ~ 20 parts, Rabdosia rubescens 8 ~ 15 parts, 2 ~ 5 parts, Herba Ephedrae, Herba Asari 2 ~ 5 parts, Rhizoma Chuanxiong 4 ~ 8 parts.
2. the Chinese medicine composition of a kind for the treatment of of allergic rhinitis according to claim 1, is characterized in that: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 15 ~ 20 parts, Fructus Xanthii 12 ~ 15 parts, the Radix Astragali 15 ~ 30 parts, Flos Magnoliae 12 ~ 15 parts, the Radix Angelicae Dahuricae 5 ~ 8 parts, Radix Saposhnikoviae 5 ~ 8 parts, Herba Schizonepetae 8 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Fructus Chebulae 4 ~ 6 parts, Herba Lophatheri 15 ~ 20 parts, Rabdosia rubescens 10 ~ 15 parts, 2 ~ 4 parts, Herba Ephedrae, Herba Asari 2 ~ 4 parts, Rhizoma Chuanxiong 4 ~ 6 parts.
3. a kind of Chinese medicine composition for the treatment of of allergic rhinitis according to claim 1 or 2, is characterized in that: raw material is made up of the Chinese medicinal components of following weight portion: Fructus Mume 18 parts, Fructus Xanthii 15 parts, the Radix Astragali 20 parts, Flos Magnoliae 12 parts, the Radix Angelicae Dahuricae 7 parts, Radix Saposhnikoviae 6 parts, Herba Schizonepetae 8 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Chebulae 6 parts, Herba Lophatheri 15 parts, Rabdosia rubescens 12 parts, 2 parts, Herba Ephedrae, Herba Asari 3 parts, Rhizoma Chuanxiong 6 parts.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105250798A (en) * | 2015-11-26 | 2016-01-20 | 王平平 | Drug for treating rhinitis chronic |
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| CN103446573A (en) * | 2013-09-25 | 2013-12-18 | 张立东 | Medicine for curing allergic rhinitis |
| CN103610788A (en) * | 2013-11-13 | 2014-03-05 | 王震 | Traditional Chinese medicine (TCM) for treating allergic rhinitis |
| CN103845580A (en) * | 2012-12-03 | 2014-06-11 | 青岛百草汇中草药研究所 | Traditional Chinese medicine composition for treating allergic rhinitis |
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| CN103845580A (en) * | 2012-12-03 | 2014-06-11 | 青岛百草汇中草药研究所 | Traditional Chinese medicine composition for treating allergic rhinitis |
| CN103446573A (en) * | 2013-09-25 | 2013-12-18 | 张立东 | Medicine for curing allergic rhinitis |
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| CN105250798A (en) * | 2015-11-26 | 2016-01-20 | 王平平 | Drug for treating rhinitis chronic |
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