CN104398664A - Zhuang pharmaceutical composition for treating anovulatory infertility - Google Patents

Zhuang pharmaceutical composition for treating anovulatory infertility Download PDF

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CN104398664A
CN104398664A CN201410634801.3A CN201410634801A CN104398664A CN 104398664 A CN104398664 A CN 104398664A CN 201410634801 A CN201410634801 A CN 201410634801A CN 104398664 A CN104398664 A CN 104398664A
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radix
zhuang
drug composition
pharmaceutical composition
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CN104398664B (en
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杨美春
方刚
林忠
黎敏
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Guangxi University of Chinese Medicine
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Abstract

The invention discloses a Zhuang pharmaceutical composition for treating anovulatory infertility. Raw materials of the Zhuang pharmaceutical composition comprise, by weight, 10-50 parts of radix fici simplicissimae, 10-40 parts of polygala fallax hemsl, 10-30 parts of Talinum crassifolium, 10-30 parts of semen cuscutae, 10-30 parts of tortoise-shell glue, 10-25 parts of morinda officinalis, 10-25 parts of Embelia parviflora, 10-30 parts of radix rehmanniae preparata, 10-30 parts of wolfberry, 10-30 parts of raspberry, 10-30 parts of amethyst and 10-30 parts of honey-fried licorice root. A preparation method of the Zhuang pharmaceutical composition comprises the following steps: respectively weighing raw materials by weight portion, cleaning and selecting, adding water and immersing; decocting for first time: cooking to ebullition under strong fire and cooking under slow fire for 20-25 min, and filtering out a liquid medicine; decocting for the second time: adding room temperature water, cooking to ebullition under strong fire and cooking under slow fire for 15-20 min, and filtering out a liquid medicine; and merging the two liquid medicines obtained by the first decoction and the second decoction. The composition provided by the invention has effects of regulating qi, dispelling dampness, regulating internal heat, tonifying the kidney and easing liver, has functions of promoting ovulation and improving symptoms such as palpitation and insomnia, soreness of loins and knees, clear abundant urine and discomfort in chest and hypochondrium, has definite, rapid and stable curative effects, and has no toxic or side effect.

Description

A kind of strong drug composition for the treatment of ovulation failure infertility
Technical field
The invention belongs to national medicine field, be specifically related to a kind of strong drug composition for the treatment of ovulation failure infertility.
Background technology
Infertility is one of common difficult and complicated illness of gynecological, and wherein ovulatory dysfunction is one of major reason, and main manifestations is anovulation and luteal phase defect, is one of primary study content in current infertility field.Infertility causes great pressure not only to infertile patient body and mind, also can cause family's contradiction, therefore, actively develop and have important social meaning and realistic meaning to the research of primary disease.At present, though Western medicine induced ovulation obtains higher ovulation rate, because it is on the growth of ovum and endometrial impact, Pregnancy Success rate is lower, and some drugs is expensive, and usage is complicated, easily occurs the complication such as side effect and multiple pregnancy.
In recent years, national medicine treatment gynecological Procreation model demonstrated good potential applicability in clinical practice.Strong medicine, as the important component part of national medicine, is that the Zhuang people are rely the effective means of preventing and curing diseases always, has played important function to the healthy of the Zhuang people and procreation.Strong doctor thinks, human body is an organic whole, and its each ingredient is closely connected, indivisible." ingeniously " (sky portion) of human body, " corridor " (people portion), " trunk " (portion) three, three roads (anus, air flue, water channel) two-way (Long Lu, Huo Lu), internal organs and " taking by force " (bone), " promise " (meat) " hiss " (gas), " strangling " (blood) etc., contact mutually, coordinative role, with nature synchronous operation, restrictionization is raw, life and growth in nature.If human righteousness is not enough, acute diseases such as cholera and sunstroke, miasma, legendary venomous insect, poison etc. are invaded in all Du Xiexunlong roads, fiery road, water channel, anus, deficient airway, and internal organs kindred is unbalance or it is foster to lose, and people from sky ground three gas are synchronously broken, then all kinds of diseases and ailments are raw.In disease treatment, strong doctor emphasize to cure the disease ask because of, based on differential diagnosis of diseases, multiselect specific prescription and medication, this is one of main feature of strong treatment method.Strong doctor have accumulated rich experiences in treatment gynaecopathia, some strong doctor's characteristic skill and technique, strong medicine proved recipe obtain good effect clinically, the Moxibustion of Zhuang Medicated Thread therapy shown unique characteristics not only has good clinical efficacy to Gynecological Pain disease, and the research in gynecological's Procreation model also obtains better effects.
For infertility, strong doctor thinks because " miaow waist " (kidney) void, " miaow is folded " (liver) stagnation of QI, stagnation of phlegm two road and " strangling " (blood) stasis of blood cause miaow flower intestinal (uterus) functional disorder, can not become pregnant by consolidating semen, and ovulatory dysfunction is infertile is mainly that " miaow waist " (kidney) is empty, " miaow is folded " (liver) stagnation of QI causes.Treatment is paid attention to " miaow waist " (kidney), " miaow fold " (liver), " hissing " (gas) " strangles " medical treatment of (blood), the dredging on Long Luhuo road.Strong medical treatment gynaecopathia has the easy honest and clean advantage tested.Therefore, develop a kind of regulating QI damp eliminating, Tong Tiaohuo road, benefit " miaow waist " relax " miaow is folded ", there is good ovulation rate effect, and obviously can improve the strong drug composition of the treatment ovulation failure infertility of the not easypro symptom of nervous insomnia, soreness of the waist and knees, clear urine in large amounts, the breast side of body, have great importance.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of effect with regulating QI damp eliminating, Tong Tiaohuo road, kidney tonifying soothing liver-QI, good ovulation rate effect, obviously can improve the strong drug composition of the treatment ovulation failure infertility of the not easypro symptom of nervous insomnia, soreness of the waist and knees, clear urine in large amounts, the breast side of body.
The present invention solves the problems of the technologies described above by the following technical programs:
A kind of strong drug composition for the treatment of ovulation failure infertility, its raw material, with parts by weight, comprises Herba Fici Simplicissimae 10 ~ 50 parts, Radix Polygalae fallacis 10 ~ 40 parts, Radix Talini Paniculati 10 ~ 30 parts, Semen Cuscutae 10 ~ 30 parts, Colla Plastri Testudinis 10 ~ 30 parts, Radix Morindae Officinalis 10 ~ 25 parts, Radix seu Caulis Embeliae Parviflorae 10 ~ 25 parts, 10 ~ 30 parts, Radix Rehmanniae Preparata, Fructus Lycii 10 ~ 30 parts, Fructus Rubi 10 ~ 30 parts, Fluoritum 10 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 30 parts.Its preparation method comprises the steps: that the raw material of above-mentioned weight portion soaks 0.5 ~ 1 hour after cleaning respectively together; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire boiling instead 20 ~ 25 minutes, is leached by medicine juice; Two decoct: rejoin normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to medicinal liquid boiling after change slow fire boiling into 15 ~ 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.
The dosage form that the present invention strengthens drug composition is decoction.
The present invention strengthens the characteristic of raw material included by medicine and herbal composite:
Herba Fici Simplicissimae: strong Gocijcwz by name, derives from the dry root of moraceae plants ficus simplicissima Ficus hirta Vahl; Nature and flavor: sweet are flat; Effect: strengthening the spleen and tonifying the lung, circulation of qi promoting dampness removing, waterway; Cure mainly: insufficiency of the spleen edema, lack of appetite are unable, pulmonary tuberculosis cough, night sweat, leukorrhagia, puerperal agalactia, menoxenia, rheumatic arthralgia, edema etc.
Radix Polygalae fallacis: strong Gosinhvahenj by name, derives from the root into milk wort Radix Polygalae fallacis Polygala aureocaudaDunn or Herb; Nature and flavor: sweet, tepor; Effect: tonify deficiency regulating QI, damp eliminating is detoxified, promoting blood circulation and hemostasis; Cure mainly: weak after being ill, puerperal blood deficiency, edema due to deficiency of the spleen, rheumatic ostalgia, hypochondriac pain, traumatic injury, metrorrhagia, traumatic hemorrhage etc.
Radix Talini Paniculati: strong Gocaenghnaengh by name, derives from the root of portulacaceous plant cone flower Radix Talini Paniculati Talinum paniculatum (Jacq.) Gaertn.; Nature and flavor: sweet are flat; Effect: invigorating the spleen and replenishing QI, the lung moistening and production of body fluid promoting, airway; Cure mainly: insufficiency of the spleen overstrain, to have loose bowels, impairment of the lung caused by overstrain cough with blood-flecked phlegm, dizzy hectic fever, night sweat spontaneous perspiration, menoxenia, is with inferior.
Semen Cuscutae: strong Faenzsenjfa by name, derives from the mature fruit of rosaceous plant Fructus Rosae Laevigatae Cuscuta chinensis Lam.; Nature and flavor: pungent, sweet, slightly warm in nature; Effect: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the solid tire of spleen invigorating; Cure mainly: lumbago tinnitus, impotence and seminal emission, quenches one's thirst, sterile, enuresis incontinence, stranguria with turbid discharge leukorrhagia, and the head is dim, and lack of appetite is had loose bowels, frequent fetal movement etc.
Colla Plastri Testudinis: strong Byukgvi by name, derives from carapace and the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray), Preparation process product; Nature and flavor: salty, sweet, are slightly cold; Effect: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood; Cure mainly: deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.
Radix Morindae Officinalis: strong Gaeusaejgaeq by name, derives from the dry root of Maguireothamnus speciosus Radix Morindae Officinalis Morinda officinalis How; Nature and flavor: sweet, pungent, tepor; Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Cure mainly: impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Radix seu Caulis Embeliae Parviflorae: strong Gaeudanghgveih by name, derives from the dry aerial parts of Myrsinacea plant Radix seu Caulis Embeliae Parviflorae Embelia parvifloraWall.ExA.DC.; Nature and flavor: bitter, puckery, warm in nature; Effect: tonifying blood and regulating menstruation, Tong Longlu, strong waist knee joint; Cure mainly: menoxenia, amenorrhea, puerperal asthenia, waist and leg ache, injury and bone fracture etc.
Radix Rehmanniae Preparata: the dried root deriving from scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch., Preparation process product; Nature and flavor: sweet, tepor; Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow; Cure mainly: the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair etc.
Fructus Lycii: derive from the dry mature fruit into plant of Solanaceae lycium barbarum Lycium barbarum L.; Nature and flavor: sweet are flat; Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight; Cure mainly: asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is not clear.
Fructus Rubi: the dry fruit deriving from Rosaceae rubus rubus chingii Hu Rubus chingii Hu.; Nature and flavor: sweet, sour, temperature; Effect: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination; Cure mainly: enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea etc.
Fluoritum: derive from fluorides mineral fluorite race fluorite, main fluorinated calcium (CaF2); Nature and flavor: sweet, temperature; Effect: tranquilizing mind, warming the lung, warm palace; Cure mainly: insomnia and dreamful sleep, palpitation and being susceptible to fright, cough and asthma due to lung deficiency, infertility etc.
Radix Glycyrrhizae Preparata: the dry root deriving from glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflataBat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L., Preparation process product; Nature and flavor: sweet are flat; Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Cure mainly: weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong etc.
In side, Herba Fici Simplicissimae, both Radix Polygalae fallaciss are principal agent; Radix Talini Paniculati, Semen Cuscutae, Colla Plastri Testudinis, Radix Morindae Officinalis, Radix seu Caulis Embeliae Parviflorae are side medicine; Radix Rehmanniae Preparata, Fructus Lycii, Fructus Rubi, Radix Glycyrrhizae Preparata are public medicine; Fluoritum is female medicine, and Quan Fangzhu helps male and female to share, effect that full side plays regulating QI damp eliminating of dispelling altogether, Tong Tiaohuo road, benefit " miaow waist " are relaxed " miaow is folded ".
The present invention has following remarkable result:
The present invention has clear and definite regulating QI damp eliminating, Tong Tiaohuo road, kidney tonifying soothing liver-QI effect, induced ovulation successful, and better can improve nervous insomnia, symptom that soreness of the waist and knees, clear urine in large amounts, the breast side of body do not relax, raising quality of life of patients; And determined curative effect, rapidly, stable, having no side effect, is a kind of good medicine for the treatment of ovulation failure infertility.
Detailed description of the invention
Below by embodiment, the invention will be further described, but not as any restriction to scope.
Embodiment 1:
1. strong drug composition comprises the raw material of following weight portion: Herba Fici Simplicissimae 30 parts, Radix Polygalae fallacis 30 parts, Radix Talini Paniculati 20 parts, Semen Cuscutae 20 parts, Colla Plastri Testudinis 20 parts, Radix Morindae Officinalis 20 parts, Radix seu Caulis Embeliae Parviflorae 20 parts, 10 parts, Radix Rehmanniae Preparata, Fructus Lycii 10 parts, Fructus Rubi 10 parts, Fluoritum 10 parts, Radix Glycyrrhizae Preparata 10 parts.
2. strong drug composition preparation method:
Take above-mentioned raw materials respectively by weight, raw material is cleaned, pour medicine pot into, soak 0.5 ~ 1 hour; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire instead and decocts 20 ~ 25 minutes again, leached by medicine juice; Two decoct: rejoin in medicine pot normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to boiling after change slow fire boiling into 15 ~ 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.It is decoction that the present invention strengthens drug composition.
3. administrated method: before menstrual onset 1 week, the administration of oral above-mentioned decoction, 1 dose/day, point sooner or later taking for 2 times, 20 days is a course for the treatment of, treatment 3 courses for the treatment of (3 menstrual cycle) continuously.
4. typical case falls ill:
River so-and-so, female, 33 years old, Hechi City people, ovulation failure infertility 2.5 years, took after this strong drug composition conceived by above-mentioned administrated method, natural labor 1 female.
Gold so-and-so, female, 27 years old, Yulin City people, ovulation failure infertility 3 years, took after this strong drug composition conceived by above-mentioned administrated method, cesarean 1 female.
Embodiment 2:
1. strong drug composition composition and components by weight percent:
Comprise Herba Fici Simplicissimae 50 parts, Radix Polygalae fallacis 40 parts, Radix Talini Paniculati 30 parts, Semen Cuscutae 30 parts, Colla Plastri Testudinis 30 parts, Radix Morindae Officinalis 25 parts, Radix seu Caulis Embeliae Parviflorae 25 parts, 30 parts, Radix Rehmanniae Preparata, Fructus Lycii 30 parts, Fructus Rubi 30 parts, Fluoritum 30 parts, Radix Glycyrrhizae Preparata 30 parts.
2. strong drug composition preparation method:
Take above-mentioned raw materials respectively by weight, raw material is cleaned, pour medicine pot into, soak 0.5 ~ 1 hour; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire instead and decocts 20 ~ 25 minutes again, leached by medicine juice; Two decoct: rejoin in medicine pot normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to boiling after change slow fire boiling into 15 ~ 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.It is decoction that the present invention strengthens drug composition.
3. application method: before menstrual onset 1 week, oral administration, 1 dose/day, point sooner or later taking for 2 times, 20 days is a course for the treatment of, treatment 3 courses for the treatment of (3 menstrual cycle) continuously.
4. typical case falls ill:
Deep so-and-so, female, 35 years old, people from Guilin City, ovulation failure infertility 3.5 years, after taking this strong drug composition by above-mentioned administrated method, cesarean 1.
Clock so-and-so, female, 29 years old, people from Nanning City, ovulation failure infertility 4 years, after taking this strong drug composition by above-mentioned administrated method, cesarean 1 female.
Embodiment 3:
1. strong drug composition composition and components by weight percent:
Comprise Herba Fici Simplicissimae 10 parts, Radix Polygalae fallacis 10 parts, Radix Talini Paniculati 10 parts, Semen Cuscutae 10 parts, Colla Plastri Testudinis 10 parts, Radix Morindae Officinalis 10 parts, Radix seu Caulis Embeliae Parviflorae 10 parts, 10 parts, Radix Rehmanniae Preparata, Fructus Lycii 10 parts, Fructus Rubi 10 parts, Fluoritum 10 parts, Radix Glycyrrhizae Preparata 10 parts.
2. strong drug composition preparation method:
Take above-mentioned raw materials respectively by weight, raw material is cleaned, pour medicine pot into, soak 0.5 ~ 1 hour; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire instead and decocts 20 ~ 25 minutes again, leached by medicine juice; Two decoct: rejoin in medicine pot normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to boiling after change slow fire boiling into 15 ~ 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.It is decoction that the present invention strengthens drug composition.
3. application method: before menstrual onset 1 week, oral administration, 1 dose/day, point sooner or later taking for 2 times, 20 days is a course for the treatment of, treatment 3 courses for the treatment of (3 menstrual cycle) continuously.
4. typical case falls ill:
Huang, female, 31 years old, people from Wuzhou, ovulation failure infertility 1.5 years, after taking this strong drug composition by above-mentioned administrated method, natural labor 1 female.
Liao so-and-so, female, 28 years old, Hechi City people, ovulation failure infertility 2 years, after taking this strong drug composition by above-mentioned administrated method, natural labor 1 female.

Claims (2)

1. treat the strong drug composition of ovulation failure infertility for one kind, it is characterized in that: its raw material, with parts by weight, comprises Herba Fici Simplicissimae 10 ~ 50 parts, Radix Polygalae fallacis 10 ~ 40 parts, Radix Talini Paniculati 10 ~ 30 parts, Semen Cuscutae 10 ~ 30 parts, Colla Plastri Testudinis 10 ~ 30 parts, Radix Morindae Officinalis 10 ~ 25 parts, Radix seu Caulis Embeliae Parviflorae 10 ~ 25 parts, 10 ~ 30 parts, Radix Rehmanniae Preparata, Fructus Lycii 10 ~ 30 parts, Fructus Rubi 10 ~ 30 parts, Fluoritum 10 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 30 parts; Its preparation method comprises the steps: that the raw material of above-mentioned weight portion soaks 0.5 ~ 1 hour after cleaning respectively together; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire boiling instead 20 ~ 25 minutes, is leached by medicine juice; Two decoct: rejoin normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to medicinal liquid boiling after change slow fire boiling into 15 ~ 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.
2. a kind of strong drug composition for the treatment of ovulation failure infertility as claimed in claim 1, is characterized in that: the dosage form of described strong drug composition is decoction.
CN201410634801.3A 2014-11-12 2014-11-12 A kind of strong drug composition for treating anovulatory infertility Active CN104398664B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105560980A (en) * 2015-12-31 2016-05-11 广西中医药大学 Zhuang medicine composition for treating perimenopausal syndromes
CN110354193A (en) * 2019-08-09 2019-10-22 苏州市吴江区中医医院（苏州市吴江区第二人民医院） A kind of Traditional Chinese medicine compound composition and its application with treatment anovulatory infertility

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘玉成编著: "《赐嗣：不孕症诊疗理论与实践》", 31 August 2007, 军事医学科学出版社 *
邓萍: "中医及中西医结合治疗排卵障碍性不孕的研究进展", 《现代中西医结合杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105560980A (en) * 2015-12-31 2016-05-11 广西中医药大学 Zhuang medicine composition for treating perimenopausal syndromes
CN110354193A (en) * 2019-08-09 2019-10-22 苏州市吴江区中医医院（苏州市吴江区第二人民医院） A kind of Traditional Chinese medicine compound composition and its application with treatment anovulatory infertility
CN110354193B (en) * 2019-08-09 2021-08-24 苏州市吴江区中医医院（苏州市吴江区第二人民医院） Traditional Chinese medicine compound composition for treating anovulatory infertility and application thereof

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