CN106361818A - Nasal cavity restoration anti-bacterium oil - Google Patents

Nasal cavity restoration anti-bacterium oil Download PDF

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Publication number
CN106361818A
CN106361818A CN201610961008.3A CN201610961008A CN106361818A CN 106361818 A CN106361818 A CN 106361818A CN 201610961008 A CN201610961008 A CN 201610961008A CN 106361818 A CN106361818 A CN 106361818A
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CN
China
Prior art keywords
nasal cavity
rhizoma atractylodis
atractylodis macrocephalae
herba menthae
angelicae dahuricae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610961008.3A
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Chinese (zh)
Inventor
曹越凡
王敏
刘骆
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Jining Shu Kang Biotechnology Co Ltd
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Jining Shu Kang Biotechnology Co Ltd
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Filing date
Publication date
Application filed by Jining Shu Kang Biotechnology Co Ltd filed Critical Jining Shu Kang Biotechnology Co Ltd
Priority to CN201610961008.3A priority Critical patent/CN106361818A/en
Publication of CN106361818A publication Critical patent/CN106361818A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether

Abstract

The invention relates to nasal cavity restoration anti-bacterium oil. The nasal cavity restoration anti-bacterium oil is prepared from 12 g to 18 g of flos magnoliae, 8 g to 15 g of ricepaperplant pith, 3 g to 7 g of mint, 8 g to 12 g of milkvetch roots, 8 g to 12 g of radix angelicae, 8 g to 12 g of rhizoma atractylodis macrocephalae and 7 g to 13 g of sesame oil. The nasal cavity restoration anti-bacterium oil has the effects of inhibiting bacteria and diminishing inflammation, and is suitable for bacterium inhibiting, cleaning and restoring of the mucosa in the nasal cavity. The mucosa in the nasal cavity is protected, restoration of tissue of the mucosa in the nasal cavity is promoted, and the nasal cavity restoration anti-bacterium oil is suitable for daily nursing of the nasal cavity.

Description

Nasal cavity repairs antibacterial oil
Technical field
The present invention relates to one kind is used for treating cacorhinia, more particularly, to a kind of nasal cavity repairs antibacterial oil.
Background technology
Weather turns cold, adds air pollution, dust storm, densely populated etc., vulnerable people just becomes easy catching a cold crowd, and Flu is easy to cause rhinitis occurred frequently.Because acute rhinitises are similar with cold symptoms, it is all nasal obstruction, headache, sneeze, rhinorrhea, has People will wrong by rhinitis when flu is controlled.Eat coldrex, but do not improved, recurrent exerbation, until having changed into chronic rhinitiss.Somebody Though knowing that oneself obtained rhinitis, thinking " do not delay to eat not delay and drink ", being minor illness.In fact, rhinitis morbidity clinical symptoms are different, Except rhinocnesmus, sneeze, time one length also results in headache, dizziness, hypomnesis etc., in addition understand concurrent emphysema, pulmonary heart disease, The serious diseases such as asthma.The prolonged and repeated outbreak of sinusitis is not got timely medical treatment again, and inflammation will diffuse to adjacent organss, group Knit.The possibility suffering from nasopharyngeal carcinoma also can be increased simultaneously.
Content of the invention
The technical problem to be solved is: provides a kind of nasal cavity for treating cacorhinia and repairs antibacterial oil, suppression Bacterium antiinflammatory is it is adaptable to the antibacterial cleaning of nasal cavity mucosa, reparation.Protection nasal cavity mucosa, promotes repairing of nasal cavity mucosal tissue Multiple it is adaptable to the daily nursing of nasal cavity.
A kind of nasal cavity repairs antibacterial oil, is made up of following crude drug: Flos Magnoliae 12-18g, Medulla Tetrapanacis 8-15g, Herba Menthae 3- 7g, Radix Astragali 8-12g, Radix Angelicae Dahuricae 8-12g, Rhizoma Atractylodis Macrocephalae 8-12g, Oleum sesami 7-13g.
Preferably, it is made up of following crude drug: Flos Magnoliae 15g, Medulla Tetrapanacis 12g, Herba Menthae 5g, Radix Astragali 10g, Radix Angelicae Dahuricae 10g, white Art 10g, Oleum sesami 10g.
The preparation method that described nasal cavity repairs antibacterial oil is: takes Flos Magnoliae, Medulla Tetrapanacis, the Radix Astragali, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae and the same medicine of Oleum sesami Put in pot, soak 24 hours, slow fire heats, and waits that exploding into blackyellow shoots, and in lower Herba Menthae, stirs evenly, cooled and filtered, sub-bottling Interior.Using rear enclosed, lucifuge is put the shady and cool place of drying and is preserved, it is to avoid direct sunlight.
The property of medicine of Chinese medicine used by the present invention is as follows:
Flos Magnoliae: abnormal smells from the patient is pungent, warm, nontoxic.Cure mainly: nasal sinusitis, nasal obstruction.Ground into powder with Flos Magnoliae, plus Moschus be a little, is dipped in nose with Bulbus Allii Fistulosi, Take effect several times.
Medulla Tetrapanacis: nature and flavor: sweet in the mouth;Light;Cold nature.Return through: enter lung, stomach.Effect and effect: snobbish clearly water;Lactogenesis.Main pouring The puckery pain of disease;Dysuria;Edema;Jaundice;Damp-warm diseases;Oliguria with reddish urine;Puerperal, breast was few;Amenorrhea;Leukorrhagia.For damp-warm syndrome urine, drench The puckery pain of disease, edema oliguria, agalactia.
Herba Menthae: Herba Menthae is Chinese conventional Chinese medicine, young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, Headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the disease such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition. Herba Menthae contains menthol, this material can fresh breath there are multiple property of medicine, stomachache, gall-bladder problem such as spasm can be alleviated, also have Have antisepsis and sterilization, diuresis, resolving sputum, stomach invigorating and aid digestion the effects such as.Eat Herba Menthae in a large number and may result in insomnia, but low dose of edible Conduce to sleep.
The Radix Astragali: nature and flavor: sweet, tepor.Return through: return lung, spleen, liver and kidney channel.The Radix Astragali has benefiting QI for strengthening the superficies, arrest sweating admittedly take off, torr sore life The effect of flesh, inducing diuresis to remove edema.For treating treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult Burst, bursts for a long time and does not holds back, blood deficiency and yellow complexion, Heat Diabetes, chronic nephritiss, albuminuria, diabetes etc..Radix Astragali Preparata invigorating middle warmer and replenishing QI, life is with admittedly Table torr sore.
The Radix Angelicae Dahuricae: nature and flavor: pungent, temperature.Return through: enter lung, spleen, stomach.Indication: wind-dispelling, dampness, detumescence, pain relieving.Control head Bitterly, supraorbital bone pain, toothache, nasal sinusitis, cold-dampness stomachache, intestines wind anal fistula, leucorrhea with red and white discharge, ulcer sores, skin is dry itches, scabies.
The Rhizoma Atractylodis Macrocephalae: meridian distribution of property and flavor: bitter in the mouth, sweet, warm in nature.Returns spleen, stomach.Indication: invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, hidroschesis, Antiabortive.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive. For spleen eating less, loose stool of having loose bowels, frequent fetal movement.
The nasal cavity of the present invention repairs antibacterial oil, and inhibiting bacteria and diminishing inflammation is it is adaptable to the antibacterial cleaning of nasal cavity mucosa, reparation.Protection Nasal cavity mucosa, the reparation promoting nasal cavity mucosal tissue is it is adaptable to the daily nursing of nasal cavity.Using front shaking up.Lie on the back and hang one's head Position, takes this product slowly uniformly to instill nasal cavity.The daily morning and evening is each once, drips a 4-5 every time and drips.
Points for attention: 1, this product external is forbidden being administered orally.2nd, eyes are avoided contact with.3rd, child uses under adult's monitoring.4、 Please this product is placed on child to be difficult the place contacting.5th, anemia of pregnant woman uses with caution.6th, using the person that has malaise symptoms after this product, should disable.7、 This product can not alternatives to medication effect.
The nasal cavity of the present invention repairs antibacterial oil, and inhibiting bacteria and diminishing inflammation is it is adaptable to the antibacterial cleaning of nasal cavity mucosa, reparation.Protection Nasal cavity mucosa, the reparation promoting nasal cavity mucosal tissue is it is adaptable to the daily nursing of nasal cavity.The nasal cavity of the present invention is repaired antibacterial Oil, can be effectively improved the symptoms such as sneeze, nasal obstruction, rhinorrhea, rhinocnesmus, there are no obvious adverse reaction over the course for the treatment of, peace Entirely effective.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1 is prepared nasal cavity and is repaired antibacterial oil
Formula is: Flos Magnoliae 15g, Medulla Tetrapanacis 12g, Herba Menthae 5g, Radix Astragali 10g, Radix Angelicae Dahuricae 10g, Rhizoma Atractylodis Macrocephalae 10g, Oleum sesami 10g.
Preparation method is: takes Flos Magnoliae, Medulla Tetrapanacis, the Radix Astragali, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae and Oleum sesami to put in pot with medicine, soaks 24 hours, literary composition Fire heating, waits that exploding into blackyellow shoots, and in lower Herba Menthae, stirs evenly, cooled and filtered, in sub-bottling.
The nasal cavity of the present invention repairs antibacterial oil, and inhibiting bacteria and diminishing inflammation is it is adaptable to the antibacterial cleaning of nasal cavity mucosa, reparation.Protection Nasal cavity mucosa, the reparation promoting nasal cavity mucosal tissue is it is adaptable to the daily nursing of nasal cavity.Using front shaking up.Lie on the back and hang one's head Position, takes this product slowly uniformly to instill nasal cavity.The daily morning and evening is each once, drips a 4-5 every time and drips.
Embodiment 2 is prepared nasal cavity and is repaired antibacterial oil
Formula is: Flos Magnoliae 17g, Medulla Tetrapanacis 10g, Herba Menthae 7g, Radix Astragali 7g, Radix Angelicae Dahuricae 12g, Rhizoma Atractylodis Macrocephalae 8g, Oleum sesami 12g.
Preparation method is with embodiment 1.
Embodiment 3 is prepared nasal cavity and is repaired antibacterial oil
Formula is: Flos Magnoliae 13g, Medulla Tetrapanacis 14g, Herba Menthae 3g, Radix Astragali 13g, Radix Angelicae Dahuricae 8g, Rhizoma Atractylodis Macrocephalae 12g, Oleum sesami 8g.
Preparation method is with embodiment 1.
Embodiment 4 is prepared nasal cavity and is repaired antibacterial oil
Formula is: Flos Magnoliae 14g, Medulla Tetrapanacis 13g, Herba Menthae 4g, Radix Astragali 11g, Radix Angelicae Dahuricae 9g, Rhizoma Atractylodis Macrocephalae 11g, Oleum sesami 9g.
Preparation method is with embodiment 1.
Embodiment 5 is prepared nasal cavity and is repaired antibacterial oil
Formula is: Flos Magnoliae 16g, Medulla Tetrapanacis 11g, Herba Menthae 6g, Radix Astragali 9g, Radix Angelicae Dahuricae 11g, Rhizoma Atractylodis Macrocephalae 9g, Oleum sesami 11g.
Preparation method is with embodiment 1.
Embodiment 6 is prepared nasal cavity and is repaired antibacterial oil
Formula is: Flos Magnoliae 15.05g, Medulla Tetrapanacis 12.15g, Herba Menthae 5.85g, Radix Astragali 10.12g, Radix Angelicae Dahuricae 10.23g, Rhizoma Atractylodis Macrocephalae 10.55g, Oleum sesami 10.46g.
Preparation method is with embodiment 1.
Clinical data:
Patient data: suffer from rhinitis degree identical patient, man 200, female 200 for 400;25~58 years old age, average 35 years old; The course of disease 0.5~6.0 year.It is randomly divided into two groups, treatment group 200, matched group 200, two groups of no difference of science of statistics.
Therapeutic modality: treatment group adopts medicine (prepared by the embodiment 1) treatment of the present invention, takes this product slowly uniformly to instill Nasal cavity, the daily morning and evening is each once, drips a 4-5 every time and drips.Matched group adopts Budesonide Nasal Spray to treat, by Sweden A Sili Kanggong department produces, specification: 64 μ g/ sprays, and 120 sprays/.Daily 2 times, each 1 time sooner or later, every time under each nostril spray 1.Treatment one After month, observe statistics curative effect.
The standard of curative effect evaluation:
Cure: the symptom such as nasal obstruction, rhinorrhea, rhinocnesmus, sneeze disappears, and no recurs within more than 3 months.
Effective: the attack times of the symptom such as nasal obstruction, rhinorrhea, rhinocnesmus, sneeze significantly reduce, and attack degree is substantially shown in Effect, but all do not disappear.
Invalid: symptom, sign slightly mitigate or the person of not being any change.
Therapeutic outcome: after treating one month, in 200 patients for the treatment of group, cure 155, effective 36, no effect 9, control More rate 77.5%, total effective rate 95.5%.Adverse reactions people is there are no in therapeutic process.In 200 patients of matched group, cure 40 Example, effective 131, invalid 29, cure rate 20%, total effective rate 85.5%.Adverse reactions people is there are no in therapeutic process.
Conclusion: the medicine of the present invention, sneeze can be effectively improved, have a stuffy nose, stay the symptoms such as nasal mucus, rhinocnesmus, can be used for treating Allergic rhinitises, there are no obvious adverse reaction, safely and effectively over the course for the treatment of.
The specific embodiment of the present invention is not construed as limiting the invention, the analog structure of every employing present invention and change Change, all within the scope of the present invention.

Claims (7)

1. a kind of nasal cavity repair antibacterial oil it is characterised in that: be made up of following crude drug: Flos Magnoliae 12-18g, Medulla Tetrapanacis 8- 15g, Herba Menthae 3-7g, Radix Astragali 8-12g, Radix Angelicae Dahuricae 8-12g, Rhizoma Atractylodis Macrocephalae 8-12g, Oleum sesami 7-13g.
2. nasal cavity according to claim 1 repair antibacterial oil it is characterised in that: be made up of following crude drug: Flos Magnoliae 15g, Medulla Tetrapanacis 12g, Herba Menthae 5g, Radix Astragali 10g, Radix Angelicae Dahuricae 10g, Rhizoma Atractylodis Macrocephalae 10g, Oleum sesami 10g.
3. nasal cavity according to claim 1 repair antibacterial oil it is characterised in that: be made up of following crude drug: Flos Magnoliae 17g, Medulla Tetrapanacis 10g, Herba Menthae 7g, Radix Astragali 7g, Radix Angelicae Dahuricae 12g, Rhizoma Atractylodis Macrocephalae 8g, Oleum sesami 12g.
4. nasal cavity according to claim 1 repair antibacterial oil it is characterised in that: be made up of following crude drug: Flos Magnoliae 13g, Medulla Tetrapanacis 14g, Herba Menthae 3g, Radix Astragali 13g, Radix Angelicae Dahuricae 8g, Rhizoma Atractylodis Macrocephalae 12g, Oleum sesami 8g.
5. nasal cavity according to claim 1 repair antibacterial oil it is characterised in that: be made up of following crude drug: Flos Magnoliae 14g, Medulla Tetrapanacis 13g, Herba Menthae 4g, Radix Astragali 11g, Radix Angelicae Dahuricae 9g, Rhizoma Atractylodis Macrocephalae 11g, Oleum sesami 9g.
6. nasal cavity according to claim 1 repair antibacterial oil it is characterised in that: be made up of following crude drug: Flos Magnoliae 16g, Medulla Tetrapanacis 11g, Herba Menthae 6g, Radix Astragali 9g, Radix Angelicae Dahuricae 11g, Rhizoma Atractylodis Macrocephalae 9g, Oleum sesami 11g.
7. nasal cavity according to any one of claim 1~6 repair antibacterial oil preparation method it is characterised in that: take pungent The name for ancient tribes in the east, Medulla Tetrapanacis, the Radix Astragali, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae and Oleum sesami are put in pot with medicine, soak 24 hours, and slow fire heats, and waits that exploding into blackyellow waves Go out, in lower Herba Menthae, stir evenly, cooled and filtered, in sub-bottling, obtain final product.
CN201610961008.3A 2016-11-04 2016-11-04 Nasal cavity restoration anti-bacterium oil Pending CN106361818A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112451602A (en) * 2020-12-29 2021-03-09 黄海兵 Production method of traditional Chinese medicine nasal wash and traditional Chinese medicine nasal wash
CN112870280A (en) * 2021-02-19 2021-06-01 北京中医药大学东直门医院 Traditional Chinese medicine fumigation lotion for nose and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1739611A (en) * 2005-08-31 2006-03-01 郭凌云 Stasis relieving oral liquid for treating rhinitis and its prepn
CN104666421A (en) * 2013-11-30 2015-06-03 烟台巨先药业有限公司 Drug for treating acute or chronic rhinitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1739611A (en) * 2005-08-31 2006-03-01 郭凌云 Stasis relieving oral liquid for treating rhinitis and its prepn
CN104666421A (en) * 2013-11-30 2015-06-03 烟台巨先药业有限公司 Drug for treating acute or chronic rhinitis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112451602A (en) * 2020-12-29 2021-03-09 黄海兵 Production method of traditional Chinese medicine nasal wash and traditional Chinese medicine nasal wash
CN112870280A (en) * 2021-02-19 2021-06-01 北京中医药大学东直门医院 Traditional Chinese medicine fumigation lotion for nose and preparation method thereof

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