CN104435944A - Traditional Chinese medicine composition for treating infantile cough and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating infantile cough and preparation method thereof Download PDF

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CN104435944A
CN104435944A CN201410808997.3A CN201410808997A CN104435944A CN 104435944 A CN104435944 A CN 104435944A CN 201410808997 A CN201410808997 A CN 201410808997A CN 104435944 A CN104435944 A CN 104435944A
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parts
radix
cough
chinese medicine
rhizoma
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刘安利
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    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/185Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a traditional Chinese medicine composition for treating infantile cough. The traditional Chinese medicine composition for treating infantile cough disclosed by the invention is composed of frost mulberry leaves, chrysanthemum, platycodon grandiflorum, fructus forsythiae, fried semen armeniacae amarae, rhizoma phragmitis, the root of kudzu vine, lalang grass rhizome, honeysuckle, folium isatidis, common hogfennel root, thunberg fritillary bulb, aster, blackberry lily, flos farfarae, chrysoidine, lily, radix glehniae, radix ophiopogonis, the tuber of stemona, radix polygonati officinalis and raw liquorice according to a certain weight ratio. The traditional Chinese medicine composition for treating infantile cough disclosed by the invention has the effects of clearing lung-heat, moistening dryness, dispelling wind, clearing heat, depressing qi, relieving cough and moistening lung to nourish yin, and is capable of effectively treating infantile cough.

Description

A kind of Chinese medicine composition for the treatment of infantile cough and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of infantile cough, the invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Infantile cough is the defensive reflex motor of one of human body, can stop foreign-body aspiration, prevent gathering of bronchial secretion, remove secretions and avoid respiratory tract secondary infection.Any cause of disease causes respiratory tract Acute and chronic inflammation all can cause cough.Exogenous cough is many be is characterized in that: morbidity is anxious, and the course of disease is short, usually concurrent flu because of caused by wind, the exopathogen such as cold, hot, dry invasion and attack, endogenous cough then has insufficiency of the spleen, the deficiency of the lung, suffer from a deficiency of the kidney not.It is characterized in that the state of an illness is delayed, the course of disease is long, recurrent exerbation.Infantile cough reacts serious than adult, and majority can be coughed incessantly, and father and mother see that child coughs a little and will go for doctor, take medicine, hang water.The result of medication has been the poor appetite of child, and appetite is bad, and nutrition does not just catch up with, the resistance of child is just poor, and so more easy to catch cold, cough of child, so this kind of child is just absorbed among vicious cycle, child often look slight of stature, ochriasis, even can cause asthma.
The traditional Chinese medical science is thought, children's's internal organs are tender and lovely, and diseases caused by exogenous pathogenic factor, internal injury are all causes cough because of all easy impairing the lung.The pathogenic factor in the exterior such as diseases caused by exogenous pathogenic factor are cold, hot, dry, the criminal's of intrusion lung, abnormal rising of lung-QI; Inside have dyspepsia, the tired raw humidogene expectorant of spleen, phlegm-damp accumulates long-pending, Lung Qi obstraction; Ferritic is weak, chronic cough impairment of body fluid, hyperactivity of deficient fire, brighter lung yin, failure of the kidney in receiving QI and giving birth to.
Current treatment infantile cough is all have an intravenous drip, have Western medicine mostly, makes every effort to get instant result, mitigation symptoms, but the side effect of Western medicine is large, dependency is strong, and after not only causing, dose is increasing, and all contains ephedrine inside a lot of antitussive, a kind of analeptic, take for a long time and have additive, and have a certain impact to the brain development of child yet tool, children's torso is not also grown completely, resistance is poor, can cause vicious cycle so for a long time.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has evident in efficacy for treatment infantile cough, cheap, easy to use, has no side effect, the feature of no dependence.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment infantile cough.
Inventor is in clinical treatment practice for many years, observe the misery of coughing and bringing to child, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of infantile cough repeatedly, the present invention selects Folium Mori, Flos Chrysanthemi, Radix Platycodonis, Fructus Forsythiae, Semen Armeniacae Amarum (parched), Rhizoma Phragmitis, Radix Puerariae, Rhizoma Imperatae, Flos Lonicerae, Folium Isatidis, Radix Peucedani, Bulbus Fritillariae Thunbergii, Radix Asteris, Rhizoma Belamcandae, Flos Farfarae, Fructus Citri tangerinae is red, Bulbus Lilii, Radix Glehniae, Radix Ophiopogonis, the Radix Stemonae, Rhizoma Polygonati Odorati, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is clearing away lung-heat and moistening for dryness, loose wind heat clearing away, sending down the abnormal ascending QI cough-relieving, effect of nourishing lung-YIN, thus effectively can treat infantile cough.
The effect of Chinese medicine of the present invention:
Wherein: Folium Mori: be the dried leaves of moraceae plants Mulberry Morus alba L..Nature and flavor: sweet, bitter, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.Folium Mori are good at loose wind heat and let out lung-heat, to affection due to external wind and heat, headache, cough etc., and the fit applications such as normal and Flos Chrysanthemi, Flos Lonicerae, Herba Menthae, Radix Peucedani, Radix Platycodonis.Clinical being mainly used in lets out clearly lung liver, and as wind heat attacks lung, cough ant phlegm, or dryness-heat impairing the lung, dry cough without phlegm are conventional medicine.
Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Nature and flavor: sweet, bitter, are slightly cold.Return lung, Liver Channel.Effect: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Flos Chrysanthemi dispelling wind is more weak, and heat clearing away power is good, often joins Folium Mori with using for affection due to external wind and heat.
Radix Platycodonis: be the root of dicotyledon campanulaceae Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A. DC..Nature and flavor are bitter, pungent, tepor.Enter lung meridian.Effect: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Radix Platycodonis is lung meridian edema caused by disorder of QI medicine, and pains are put down, and namely rises and falls, being good at a surname and opening lung qi, therefore exopathogen violates lung, cough with copious phlegm, and disease such as grade uncomfortable in chest of having a stuffy nose, no matter cold and heat all can adapted.
Fructus Forsythiae: be the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Nature and flavor: bitter, are slightly cold.Return lung, the heart, small intestine meridian.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Antibacterial action: Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.
Semen Armeniacae Amarum (parched): be the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. (bitter Fructus Pruni) Prunus armeniaca L. var. ansu Maxim., Siberia Fructus Pruni (Prunus armeniaca L.var.ansu Maxim.) Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..Nature and flavor: bitter, tepor; Slightly poisonous.Return lung, large intestine channel.Effect: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.
Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Clinical Shanghai is usually used in clearing away lung-heat to relieve cough.
Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Nature and flavor are cool, sweet, pungent.Enter spleen, stomach warp.Effect: induce sweat and bring down a fever, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Radix Puerariae has diaphoresis, antipyretic effect, has obvious refrigeration function.
Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.
Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. are just opened.Nature and flavor: sweet, cold.Return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-dispelling heat-dissipating.For affection due to external wind and heat or epidemic febrile disease from the beginning of.Flos Lonicerae is sweet cold, both clearing heat in QI system, and can purify the blood again a point heat, and has again among heat clearing away and slightly declare loose merit, thus can control affection due to external wind and heat or epidemic febrile disease from the beginning of the disease that table disease is not separated, interior-heat is contained again.
Folium Isatidis: be the dried leaves of cruciferae isatis Isatis indigotica Fort..Nature and flavor: bitter, cold.Return liver, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Be mainly used in pyretic toxicity and send out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.This product bitter cold, be removing toxic substances key medicine, have stronger antivirus action, modern with controlling upper respiratory tract infection, influenza, encephalitis, viral pneumonia, hepatitis, enteritis etc. have good curative effect.
Radix Peucedani: be the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum Maxim..Nature and flavor: bitter, pungent, are slightly cold.Return lung meridian.Effect: loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.For cough due to pathogenic wind-heat's abundant expectoration, expectorant dyspnea of heat type is full, coughs up phlegm yellow thick.This product hardship can be fallen and be let out, the heat clearing away of cold energy, for accumulation of phlegm-heat in the lung, and impairment of dispersing and descending function of the lung.Radix Peucedani can also dispersing wind-cold, and dispersing lung-QI and dissipating phlegm, for cough with copious phlegm person.
Bulbus Fritillariae Thunbergii: be the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii Fritillaria thunbergii Miq..Nature and flavor: bitter, cold.Return lung, heart channel.Effect: heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing.For wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore." book on Chinese herbal medicine just " is recorded: control greatly lung abscess lung and wither, cough with asthma, and spit blood, mental disorder, falls most in epistaxis, kind relieving stagnation, and relieve the pain pain, and relieving distension is full, clearing away liver-fire, improve visual and auditory acuity.
Radix Asteris: be the dry root and rhizome of feverfew Radix Asteris Aster tataricus L. f..Nature and flavor: pungent, bitter, temperature.Return lung meridian.Effect: nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.This product master enters lung meridian, and bitter in the mouth falls to be let out, slightly warm in nature and matter profit, has again the property of unclogging and readjusting and opening concurrently, can fall lung qi, again can lung qi dispersing gas and reach the merit of relieving cough and asthma, is the key medicine for the treatment of cough with asthma.Pharmacology's eyes Radix Asteris also has significantly antibacterial and antiviral effect.
Rhizoma Belamcandae: be the dry rhizome of irides Rhizoma Belamcandae Belamcanda chinensis (L.) DC..Nature and flavor: bitter, cold.Return lung meridian.Effect: heat-clearing and toxic substances removing, expectorant, sore-throat relieving.For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.With controlling cough phlegm dyspnea, the fit applications such as normal and Herba Ephedrae, Radix Asteris, coltsfoot." Bencao Jingshu ": " Rhizoma Belamcandae, hardship can be let out down, therefore is apt to fall; Hold concurrently pungent, thus kind loose.Therefore main cough with dyspnea, sore throat pharyngalgia, must not message, and eliminating stagnation gas is evil inverse in the heart.Both fallen and fallen apart, benefit is to be slightly cold, therefore the large heat of staple food drink.
Flos Farfarae: be the dry flower of feverfew coltsfoot Tussilago farfara L..Nature and flavor: pungent, micro-hardship, temperature.Return lung meridian.Effect: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.Be mainly used in asthma and chronic tracheitis clinically." property of medicine opinion ": the main treatment lung qi heart is urged, anxious hot weary labor, cough repeatedly without cease, tears saliva is sticky.Control consumptive lung disease lung abscess vomiting pus.
Exocarpium Citri Rubrum: be the dry outside rind of rutaceae Huazhou Fructus Citri tangerinae Citrus grandis Osbeck var. tomentosa Hort. or Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof.Nature and flavor: pungent, bitter, temperature.Return lung, spleen channel.Effect: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed." medicineization justice ": Exocarpium Citri Rubrum, pungently can walk crosswise eliminating stagnation, and bitter decline of keeping straight on is promoting the circulation of QI key medicine.Lid is controlled expectorant and must be regulated the flow of vital energy, the spontaneous recovery of diarrhea due to disorder of QI expectorant, therefore with entering lung spleen, all expectorant main are sick, and merit occupies on all expectorant medicines.Assistant Caulis Bambusae In Taenia, to treat heat-hiccup, helps Pericarpium Citri Reticulatae Viride with intestinal stasis relieving gas, real in the flat stomach of same Rhizoma Atractylodis, Cortex Magnoliae Officinalis, and the heresy that conjunction Bulbus Allii Fistulosi, Herba Ephedrae exterior cold are wet, rapid digestion of food gas, alcoholic intoxication, anti-nausea, opens chest and diaphragm painful abdominal mass plug, can push away Chen Zhixin, and the power that all pungent loose hardship is fallen also.
Bulbus Lilii: be the dry meat scale leaf of liliaceous plant tiger lily Lilium lancifolium Thunb., Bulbus Lilii Lilium brownii F.E.Brown var. viridulum Baker or Lilium tenuifolium Lilium pumilum DC..Nature and flavor: sweet, cold.GUIXIN, lung meridian.Effect: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded." Bencao Jingshu ": Bulbus Lilii, main pathogen abdominal distention.So-called pathogen person, namely pathogenic heat also.Pathogenic heat are in abdomen event abdominal distention, and its pathogenic heat are then swollen clearly disappears.Separate the pathogenic heat of sharp heart man, then pained from Liao.Kidney controlling urination and defecation, kidney and large intestine two are through having pathogenic heat then not tonneau, the pathogenic heat of clear two warps, then defecation diarrhea.The invigorating middle warmer of sweet energy, the clear then gas of heat is raw, therefore invigorating the spleen and replenishing QI.Heat clearing away diuresis, thus except edema, set out swollen.Feeling of fullness cold and heat, the whole body pain, breast is difficult, and sufficient Yang Mingre is also; Sore throat person, hands few sun three Jiao, hands few cloudy heart man heat are also; Tears, tear, lung liver-heat is also; Clear sun bright three is felt terribly worried the heat in portion, then all diseases of coming up are from removing.
Radix Glehniae: be the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq..Nature and flavor: sweet, micro-hardship, to be slightly cold.Return lung, kidney channel.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Research display: Radix Glehniae not only has the effect of antipyretic-antalgic, can also strengthen body immunity.
Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.
The Radix Stemonae: be the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Nature and flavor: sweet, bitter, tepor.Return lung meridian.Slightly poisonous.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.Research shows that Radix stemonae japonicae infusion is in vitro to various pathogens, and some pathomycete has certain inhibitory action.
Rhizoma Polygonati Odorati: be the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.Nature and flavor: sweet, are slightly cold.Attach to the lung and stomach meridians.Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.This product sweet in the mouth, greasiness, soft and moist edible, be longer than yin nourishing, mainly act on taste, therefore take not imapirment of the spleen and stomach for a long time, cure mainly the few expectorant of dry cough caused by deficiency of lung-YIN, pharynx dryness of the tongue and epidemic febrile disease later stage, or Tianjin of occurring is few thirsty, inappetence, the diseases such as stomach discomfort because hyperpyrexia consumption impairment of body fluid liquid.The merit that this product is mended and oiliness, cold not dry, therefore has " tonification the five internal organs, nourish QI and blood, flat benefit and moistening, and hold concurrently except wind heat ", has the effect of nourishing calm neural and heart tonifying.Be applicable to cardiopalmus, angina pectoris.Confirm through modern medicine study, Rhizoma Polygonati Odorati has hypoglycemic activity, also has moist skin, and the effect of spraining is got injured by a fall in dissipation skin chronic inflammatory disease and treatment.
Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Folium Mori clearing away lung-heat and moistening for dryness in side, the heat clearing away of chrysanthemum powder forimproving wind, Radix Platycodi (Radix Platycodonis) lung qi dispersing eliminates the phlegm, sore-throat relieving evacuation of pus, Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, Semen Armeniacae Amarum (parched) sending down the abnormal ascending QI relieving cough and asthma, the above five tastes are monarch drug altogether, fundamentally first carry out loose wind heat clearing away from disease, prevent pathogenic heat from invading lung, then carry out heat-clearing and toxic substances removing, sending down the abnormal ascending QI cough-relieving, and monarch drug also has broad-spectrum antibacterial action, be equivalent to the antibiotic on Western medicine, and can not drug resistance be produced, do not have full grown health to reduce toxic and side effects to child, reduce drug dependence.Rhizoma Phragmitis clearing away heat and promoting production of body fluid, Radix Puerariae induces sweat and brings down a fever, imperata rhizome heat-clearing diuretic, Flos Lonicerae, the removing toxic substances of Folium Isatidis fresh breeze, dispelling wind and heat pathogens, Radix Peucedani lowering the adverse-rising QI to resolve phlegm, Bulbus Fritillariae Thunbergii heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, above seven tastes are ministerial drug altogether, strengthen on the one hand monarch drug fall apart wind heat clearing away, the drug effect of clearing away heat and promoting production of body fluid, carry out lowering the adverse-rising QI to resolve phlegm on the other hand, lung qi closing are not declared, and respectfully fall dereliction of duty, QI rising in reverse order then causes cough, or interior machine intrinsic heat, and Tianjin is gathered for expectorant, obstruction of QI-passage, QI rising in reverse order is defeated and causes cough.Ministerial drug strengthens effect of lowering the adverse-rising QI to resolve phlegm simultaneously, fundamentally treats infantile cough.Radix Asteris nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm, Rhizoma Belamcandae expectorant sore-throat relieving, Flos Farfarae nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm, Exocarpium Citri Rubrum is regulated the flow of vital energy expectorant, Bulbus Lilii, Radix Glehniae nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, Radix Ophiopogonis, Radix Stemonae nourishing lung-YIN, Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, a few taste is adjuvant drug altogether above, mainly nourishing YIN and moistening the lung, to regulate the flow of vital energy effect of expectorant, the traditional Chinese medical science is said, lung is tender dirty, especially easily be subject to the invasion and attack of exopathogen and interior heresy, the health of child is natively weak, a large amount of use antimicrobial drugs produces drug resistance and does not say, also can cause certain injury to the hepatic and renal function of child, adjuvant drug is to support, tonifying the lung lung moistening, treatment infantile cough, Radix Glycyrrhizae spleen reinforcing stomach function regulating, coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has clearing away lung-heat and moistening for dryness, and loose wind heat clearing away, sending down the abnormal ascending QI cough-relieving, effect of nourishing lung-YIN, effectively can treat infantile cough.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Folium Mori 4-14 part, Flos Chrysanthemi 3-9 part, Radix Platycodonis 4-14 part, Fructus Forsythiae 3-9 part, Semen Armeniacae Amarum (parched) 1-7 part, Rhizoma Phragmitis 10-20 part, Radix Puerariae 4-14 part, Rhizoma Imperatae 10-20 part, Flos Lonicerae 7-17 part, Folium Isatidis 4-14 part, Radix Peucedani 3-9 part, Bulbus Fritillariae Thunbergii 3-9 part, Radix Asteris 4-14 part, Rhizoma Belamcandae 3-9 part, Flos Farfarae 3-9 part, Exocarpium Citri Rubrum 3-9 part, Bulbus Lilii 4-14 part, Radix Glehniae 7-17 part, Radix Ophiopogonis 4-14 part, Radix Stemonae 4-14 part, Rhizoma Polygonati Odorati 5-15 part, Radix Glycyrrhizae 1-5 part.
Wherein be preferably: Folium Mori 9 parts, Flos Chrysanthemi 6 parts, Radix Platycodonis 9 parts, Fructus Forsythiae 6 parts, Semen Armeniacae Amarum (parched) 4 parts, Rhizoma Phragmitis 15 parts, Radix Puerariae 9 parts, Rhizoma Imperatae 15 parts, Flos Lonicerae 12 parts, Folium Isatidis 9 parts, Radix Peucedani 6 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Asteris 9 parts, Rhizoma Belamcandae 6 parts, Flos Farfarae 6 parts, Exocarpium Citri Rubrum 6 parts, Bulbus Lilii 9 parts, Radix Glehniae 12 parts, Radix Ophiopogonis 9 parts, the Radix Stemonae 9 parts, Rhizoma Polygonati Odorati 10 parts, Radix Glycyrrhizae 3 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of infantile cough is as follows:
Step one: by weight proportion of the present invention, by Radix Platycodonis, Rhizoma Phragmitis, Radix Puerariae, Rhizoma Imperatae, Radix Peucedani, Radix Asteris, Rhizoma Belamcandae, Radix Glehniae, Radix Ophiopogonis, the Radix Stemonae is put into marmite and is added cold water, exceed powder 3 ~ 4 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Folium Mori is added, Fructus Forsythiae, Folium Isatidis, Bulbus Fritillariae Thunbergii, Fructus Citri tangerinae is red, Bulbus Lilii, Rhizoma Polygonati Odorati decocts about 30 minutes, finally add Flos Chrysanthemi, Flos Lonicerae, Flos Farfarae, Radix Glycyrrhizae continues decoction 10 minutes, filter, obtain filtrate, merge twice filtrate, and when filtrate being concentrated into about 80 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment,
Step 2: by weight proportion of the present invention, grinds into powder Semen Armeniacae Amarum (parched) and is crushed to 200 mesh sieves, for subsequent use;
Step 3: in step 2, gained fine powder adds in step one gained thick paste and is uniformly mixed, dry, be ground into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 10g/ bag, every bag of granule containing crude drug 5g.
Medicine of the present invention has clearing away lung-heat and moistening for dryness, loose wind heat clearing away, sending down the abnormal ascending QI cough-relieving, the effects such as nourishing lung-YIN, and evident in efficacy, cheap, easy to use, have no side effect, no dependence, the mode that this Chinese medicine preparation adopts is treated and can be reduced the damage of Western medicine to child's hepatic and renal function, accelerates the improvement of the state of an illness.According to clinical 200 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 98%.
Detailed description of the invention
Embodiment one, Folium Mori 4 parts, Flos Chrysanthemi 3 parts, Radix Platycodonis 4 parts, Fructus Forsythiae 3 parts, Semen Armeniacae Amarum (parched) 1 part, Rhizoma Phragmitis 10 parts, Radix Puerariae 4 parts, Rhizoma Imperatae 10 parts, Flos Lonicerae 7 parts, Folium Isatidis 4 parts, Radix Peucedani 3 parts, Bulbus Fritillariae Thunbergii 3 parts, Radix Asteris 4 parts, Rhizoma Belamcandae 3 parts, Flos Farfarae 3 parts, Exocarpium Citri Rubrum 3 parts, Bulbus Lilii 4 parts, Radix Glehniae 7 parts, Radix Ophiopogonis 4 parts, the Radix Stemonae 4 parts, Rhizoma Polygonati Odorati 5 parts, Radix Glycyrrhizae 1 part.
Embodiment two, Folium Mori 9 parts, Flos Chrysanthemi 6 parts, Radix Platycodonis 9 parts, Fructus Forsythiae 6 parts, Semen Armeniacae Amarum (parched) 4 parts, Rhizoma Phragmitis 15 parts, Radix Puerariae 9 parts, Rhizoma Imperatae 15 parts, Flos Lonicerae 12 parts, Folium Isatidis 9 parts, Radix Peucedani 6 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Asteris 9 parts, Rhizoma Belamcandae 6 parts, Flos Farfarae 6 parts, Exocarpium Citri Rubrum 6 parts, Bulbus Lilii 9 parts, Radix Glehniae 12 parts, Radix Ophiopogonis 9 parts, the Radix Stemonae 9 parts, Rhizoma Polygonati Odorati 10 parts, Radix Glycyrrhizae 3 parts.
Embodiment three, Folium Mori 14 parts, Flos Chrysanthemi 9 parts, Radix Platycodonis 14 parts, Fructus Forsythiae 9 parts, Semen Armeniacae Amarum (parched) 7 parts, Rhizoma Phragmitis 20 parts, Radix Puerariae 14 parts, Rhizoma Imperatae 20 parts, Flos Lonicerae 17 parts, Folium Isatidis 14 parts, Radix Peucedani 9 parts, Bulbus Fritillariae Thunbergii 9 parts, Radix Asteris 14 parts, Rhizoma Belamcandae 9 parts, Flos Farfarae 9 parts, Exocarpium Citri Rubrum 9 parts, Bulbus Lilii 14 parts, Radix Glehniae 17 parts, Radix Ophiopogonis 14 parts, the Radix Stemonae 14 parts, Rhizoma Polygonati Odorati 15 parts, Radix Glycyrrhizae 5 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 400 example for medical treatment.Patient is divided into observation group and matched group at random, wherein male 220 example, women 180 example, M-F 1.2:1, max age 13 years old, minimal ages 10 months, every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, Therapeutic Method
1, observation group is according to Medications Example two of the present invention, and granule prepared by preferred preparation method, and boiled water is taken after mixing it with water, every day 3 times, each one bag.It within 7th, is a course for the treatment of.
2, matched group is according to the Chinese medicine composition decoction for the treatment of infantile cough in CN 104161790 A, patient's morning and evening service once every day, within 7 days, is an observation period.
Three, efficacy assessment standard
1, cure: cough and other clinical symptom disappearance, body constitution recovers normal.
2, take a turn for the better: cough takes a turn for the better, and do not affect living and studying at ordinary times, body constitution takes a turn for the better gradually.
3, do not heal: cough phenomenon even increases the weight of without any improvement.
Four, observation group's result statistics
Matched group result is added up
Wherein: total effective rate=cure rate+improvement rate
Take the Comparison of therapeutic situation of two groups of patients, two courses for the treatment of
Can find that observation group is apparently higher than matched group, illustrates thus by the treatment total effective rate contrasting two groups of patients, Chinese medicine of the present invention has good clinical effectiveness at treatment infantile cough, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Guo, female, 3 years old, continuous cough about two weeks, coughs low voice speaking, turbid nasal discharge, throat is itched, and aversion to cold is lossless, and thin lingual fur, Huang are greasy, patient especially evening time even more serious, cause increasing the weight of all to have a rest bad with child, come here and go to a doctor, adopt case two method of the present invention, after taking a course for the treatment of, patient coughs and obviously alleviates, and can normally have a rest in the evening, because body constitution is poor before, for consolidating drug effect, continue two courses for the treatment of of drug administration, other symptoms such as cough disappear completely, and body constitution also increases, have no recurrence, recovery from illness.
Case two, in certain, man, 1 years old half, heating, cough, abundant expectoration, color white matter is rare, gurgling with sputum, uneasy sleeping at night, and light red tongue, tongue are greasy in vain, auscultation: two lungs can hear a large amount of rale.Because child is too little, the head of a family is unwilling to use Western medicine, adopts treatment by Chinese herbs method, comes here and goes to a doctor, adopt case two method of the present invention, after taking a course for the treatment of, cough alleviates, and amount of expectoration reduces, after continue to take a course for the treatment of, patient's cough, abundant expectoration phenomenon disappear completely, and have a rest normal in the evening, and body constitution also strengthens to some extent.
Case three, Zhang, female, 5 years old, affection of exogenous wind-cold, expectorant color is thin in vain, snivel, for heating, cough is more than, comes here and goes to a doctor, adopt case two method of the present invention, after taking a course for the treatment of, itching throat, snivel phenomenon are clearly better, cough is converted into discontinuity cough incessantly, continues to take a course for the treatment of, and patient's phenomenon of coughing disappears completely, other clinical symptoms are also taken a turn for the better, and body constitution also strengthens to some extent, recovery from illness.

Claims (4)

1. treat the Chinese medicine composition of infantile cough for one kind, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Folium Mori 4-14 part, Flos Chrysanthemi 3-9 part, Radix Platycodonis 4-14 part, Fructus Forsythiae 3-9 part, Semen Armeniacae Amarum (parched) 1-7 part, Rhizoma Phragmitis 10-20 part, Radix Puerariae 4-14 part, Rhizoma Imperatae 10-20 part, Flos Lonicerae 7-17 part, Folium Isatidis 4-14 part, Radix Peucedani 3-9 part, Bulbus Fritillariae Thunbergii 3-9 part, Radix Asteris 4-14 part, Rhizoma Belamcandae 3-9 part, Flos Farfarae 3-9 part, Exocarpium Citri Rubrum 3-9 part, Bulbus Lilii 4-14 part, Radix Glehniae 7-17 part, Radix Ophiopogonis 4-14 part, Radix Stemonae 4-14 part, Rhizoma Polygonati Odorati 5-15 part, Radix Glycyrrhizae 1-5 part.
2. the Chinese medicine composition of the treatment infantile cough according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Folium Mori 9 parts, Flos Chrysanthemi 6 parts, Radix Platycodonis 9 parts, Fructus Forsythiae 6 parts, Semen Armeniacae Amarum (parched) 4 parts, Rhizoma Phragmitis 15 parts, Radix Puerariae 9 parts, Rhizoma Imperatae 15 parts, Flos Lonicerae 12 parts, Folium Isatidis 9 parts, Radix Peucedani 6 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Asteris 9 parts, Rhizoma Belamcandae 6 parts, Flos Farfarae 6 parts, Exocarpium Citri Rubrum 6 parts, Bulbus Lilii 9 parts, Radix Glehniae 12 parts, Radix Ophiopogonis 9 parts, the Radix Stemonae 9 parts, Rhizoma Polygonati Odorati 10 parts, Radix Glycyrrhizae 3 parts.
3. the Chinese medicine preparation for the treatment of infantile cough according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is granule.
4. treat the preparation method of the Chinese medicine preparation of infantile cough for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, by Radix Platycodonis, Rhizoma Phragmitis, Radix Puerariae, Rhizoma Imperatae, Radix Peucedani, Radix Asteris, Rhizoma Belamcandae, Radix Glehniae, Radix Ophiopogonis, the Radix Stemonae is put into marmite and is added cold water, exceed powder 3 ~ 4 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Folium Mori is added, Fructus Forsythiae, Folium Isatidis, Bulbus Fritillariae Thunbergii, Fructus Citri tangerinae is red, Bulbus Lilii, Rhizoma Polygonati Odorati decocts about 30 minutes, finally add Flos Chrysanthemi, Flos Lonicerae, Flos Farfarae, Radix Glycyrrhizae continues decoction 10 minutes, filter, obtain filtrate, merge twice filtrate, and when filtrate being concentrated into about 80 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, step 2: by weight proportion of the present invention, grinds into powder Semen Armeniacae Amarum (parched) and is crushed to 200 mesh sieves, for subsequent use, step 3: in step 2, gained fine powder adds in step one gained thick paste and is uniformly mixed, dry, be ground into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 10g/ bag, every bag of granule containing crude drug 5g.
CN201410808997.3A 2014-12-24 2014-12-24 Traditional Chinese medicine composition for treating infantile cough and preparation method thereof Pending CN104435944A (en)

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CN105288384A (en) * 2015-10-26 2016-02-03 赵丽 Cough medicine and preparation method thereof
CN106309994A (en) * 2016-10-20 2017-01-11 华北理工大学 Method for preparing oral liquid for treating lung dryness cough
CN107397897A (en) * 2016-05-21 2017-11-28 陈茹 A kind of Chinese patent drug for treating children's diphtheria and preparation method thereof
CN107468970A (en) * 2017-09-06 2017-12-15 成都兴倍加生物科技有限责任公司 A kind of pill medicine for treating infantile cough and preparation method thereof
CN110354215A (en) * 2019-09-02 2019-10-22 石家庄市第五医院 It is a kind of to press from both sides the Chinese medicine composition of wet type cough, drug and preparation method thereof for treating Lung-Yin deficiency
CN110604806A (en) * 2019-10-17 2019-12-24 黎芷杉 Traditional Chinese medicine preparation for treating infantile cough and preparation method thereof
CN111035683A (en) * 2019-12-30 2020-04-21 云南继创中草药技术有限公司 Hawthorn and dried orange peel paste for treating infantile cough and preparation method and application thereof
CN111558002A (en) * 2019-05-28 2020-08-21 葵花药业集团湖北武当有限公司 Preparation method of autumn pear lung moistening paste
CN111558012A (en) * 2020-07-03 2020-08-21 金咏庚 Traditional Chinese medicine composition for treating infantile bronchitis and preparation method thereof
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Publication number Priority date Publication date Assignee Title
CN105105235A (en) * 2015-06-18 2015-12-02 湖南湘雅制药有限公司 Anti-haze drink and preparation method thereof
CN105288384A (en) * 2015-10-26 2016-02-03 赵丽 Cough medicine and preparation method thereof
CN107397897A (en) * 2016-05-21 2017-11-28 陈茹 A kind of Chinese patent drug for treating children's diphtheria and preparation method thereof
CN106309994A (en) * 2016-10-20 2017-01-11 华北理工大学 Method for preparing oral liquid for treating lung dryness cough
CN107468970A (en) * 2017-09-06 2017-12-15 成都兴倍加生物科技有限责任公司 A kind of pill medicine for treating infantile cough and preparation method thereof
CN111558002A (en) * 2019-05-28 2020-08-21 葵花药业集团湖北武当有限公司 Preparation method of autumn pear lung moistening paste
CN110354215A (en) * 2019-09-02 2019-10-22 石家庄市第五医院 It is a kind of to press from both sides the Chinese medicine composition of wet type cough, drug and preparation method thereof for treating Lung-Yin deficiency
CN110354215B (en) * 2019-09-02 2023-10-10 石家庄市第五医院 Traditional Chinese medicine composition and medicine for treating cough caused by lung yin deficiency with dampness and preparation method of traditional Chinese medicine composition and medicine
CN110604806A (en) * 2019-10-17 2019-12-24 黎芷杉 Traditional Chinese medicine preparation for treating infantile cough and preparation method thereof
CN111035683A (en) * 2019-12-30 2020-04-21 云南继创中草药技术有限公司 Hawthorn and dried orange peel paste for treating infantile cough and preparation method and application thereof
CN111558012A (en) * 2020-07-03 2020-08-21 金咏庚 Traditional Chinese medicine composition for treating infantile bronchitis and preparation method thereof
CN115252732A (en) * 2022-06-08 2022-11-01 宁波市第一医院 Traditional Chinese medicine composition for clearing lung and relieving cough and application thereof
CN115252732B (en) * 2022-06-08 2023-11-14 宁波市第一医院 Traditional Chinese medicine composition for clearing lung and relieving cough and application thereof

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