CN111558002A - Preparation method of autumn pear lung moistening paste - Google Patents

Preparation method of autumn pear lung moistening paste Download PDF

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Publication number
CN111558002A
CN111558002A CN201910452461.5A CN201910452461A CN111558002A CN 111558002 A CN111558002 A CN 111558002A CN 201910452461 A CN201910452461 A CN 201910452461A CN 111558002 A CN111558002 A CN 111558002A
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Prior art keywords
autumn
pear
fritillariae cirrhosae
bulbus fritillariae
steps
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Inventor
黄正军
何德苟
肖作武
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Sunflower Group Hubei Wudang Co ltd
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Sunflower Group Hubei Wudang Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967Lilium, e.g. tiger lily or Easter lily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a preparation method of autumn pear lung-moistening paste. Belongs to the technical field of traditional Chinese medicines. The autumn pear lung moistening paste mainly solves the problems of high medicine viscosity and excessively sweet and greasy taste of autumn pear lung moistening paste. It is mainly characterized in that:
Figure DEST_PATH_IMAGE001
putting the autumn pears into a juicer to be smashed,Squeezing, and centrifuging at high speed to separate succus Pyri from fructus Pyri residue;
Figure 177059DEST_PATH_IMAGE002
decocting fructus Pyri residue with twice of water, centrifuging, mixing the supernatant with fructus Pyri juice, and concentrating under reduced pressure to obtain fructus Pyri fluid extract with relative density of 1.30;
Figure DEST_PATH_IMAGE003
percolating Bulbus Fritillariae Cirrhosae and radix Ophiopogonis with ethanol, and collecting percolate;
Figure 782615DEST_PATH_IMAGE004
decocting Bulbus Lilii and flos Farfarae in water for three times; centrifuging, and concentrating the supernatant under reduced pressure to obtain fluid extract with relative density of 1.25; adding ethanol, collecting supernatant, mixing with percolate of Bulbus Fritillariae Cirrhosae and radix Ophiopogonis, concentrating under reduced pressure to obtain fluid extract with relative density of 1.30,

Description

Preparation method of autumn pear lung moistening paste
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of autumn pear lung-moistening paste.
Background
In autumn, dry and dry in the sky, most people are easy to have a series of seasonal symptoms such as dry mouth and tongue, lung heat and polydipsia. Great inconvenience is brought to the work and life of patients, severe patients can cause respiratory diseases, if the patients are not treated in time, diseases on respiratory tract such as chronic pharyngitis can be caused, and the diseases are difficult to cure.
Autumn pear lung moistening paste has effects of moistening lung, relieving cough, promoting fluid production and relieving sore throat. Can be used for treating cough with short breath, little phlegm and sticky mass, dry mouth and throat, and laryngalgia and hoarseness caused by yin deficiency and lung heat.
At present, autumn pear lung moistening paste is prepared from pears, bulbus fritillariae cirrhosae, radix ophiopogonis, lilies, coltsfoot flowers, rock sugar and old honey, pear juice and pear residues are separated by a filtering method for pear clear paste extraction, and the lilies and the coltsfoot flowers are not subjected to an alcohol precipitation process. The disadvantages are that the prepared clear paste and the prepared finished product have high relative density which reaches 1.45 (50 ℃) because of the relatively high content of the rock sugar and the old honey, and the medicine has high viscosity and is inconvenient to take; in addition, there is a problem that the taste is too sweet and greasy, and the appearance is impaired.
Disclosure of Invention
The invention aims to provide a preparation method of autumn pear lung-moistening paste, which has the advantages of reduced density, improved taste and appearance and reduced impurity content.
The technical solution of the invention is as follows: a preparation method of autumn pear lung moistening paste is characterized by comprising the following steps:
Figure 100002_DEST_PATH_IMAGE002
cleaning autumn pears, placing the autumn pears in a juicer for mincing, extruding and centrifuging at a high speed to separate pear juice from pear residues, and collecting the pear juice for later use;
Figure 100002_DEST_PATH_IMAGE004
decocting the separated pear residues with water twice of the pear residues, centrifuging, mixing the supernatant with pear juice, and concentrating under reduced pressure to obtain pear extract with relative density of 1.30;
Figure 100002_DEST_PATH_IMAGE006
pulverizing Bulbus Fritillariae Cirrhosae into coarse powder, percolating with ethanol, collecting percolate, and recovering ethanol under reduced pressure;
Figure 100002_DEST_PATH_IMAGE008
rolling radix Ophiopogonis, percolating with ethanol, collecting percolate, and recovering ethanol under reduced pressure;
Figure 100002_DEST_PATH_IMAGE010
decocting Bulbus Lilii and flos Farfarae in water for three times; centrifuging, concentrating the supernatant under reduced pressure to obtain fluid extract with relative density of 1.25, cooling to room temperature, adding ethanol to make ethanol content reach 60%, standing, collecting supernatant, mixing with Bulbus Fritillariae Cirrhosae percolate and radix Ophiopogonis percolate, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.30;
Figure 100002_DEST_PATH_IMAGE012
mixing the fluid extracts with fructus Pyri fluid extract and maltose syrup to obtain mixed fluid extract; adding 50g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
Description of the invention
Figure 328915DEST_PATH_IMAGE002
The autumn pears in the step are 400-800 g; first, the
Figure 934471DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the steps is 50-160 g; first, the
Figure 714208DEST_PATH_IMAGE008
The ophiopogon root in the step is 40-100 g; first, the
Figure 47100DEST_PATH_IMAGE010
The lily in the step is 20-60g, and the coltsfoot flower is 20-60 g; first, the
Figure 861473DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 870886DEST_PATH_IMAGE002
The autumn pears in the step are 500-700 g; first, the
Figure 137919DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the steps is 80-140 g; first, the
Figure 274502DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 60-130 g; first, the
Figure 943381DEST_PATH_IMAGE010
25-50g of lily and 25-55g of coltsfoot flower in the steps; first, the
Figure 625160DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 379490DEST_PATH_IMAGE002
The autumn pears in the step are 550 g; first, the
Figure 54185DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 130 g; first, the
Figure 764521DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 85 g; first, the
Figure 194365DEST_PATH_IMAGE010
The lily in the step is 55g, and the coltsfoot flower is 50 g; first, the
Figure 373673DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 648797DEST_PATH_IMAGE002
The autumn pears in the steps are 800 g; first, the
Figure 980684DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 50 g; first, the
Figure 315850DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 100 g; first, the
Figure 982455DEST_PATH_IMAGE010
The lily in the step is 60g, and the coltsfoot flower is 20 g; first, the
Figure 61269DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 746197DEST_PATH_IMAGE002
400g of autumn pears in the steps; first, the
Figure 517844DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (b) is 160 g; first, the
Figure 406166DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 40 g; first, the
Figure 288671DEST_PATH_IMAGE010
The lily in the step is 20g, and the coltsfoot flower is 60 g; first, the
Figure 329570DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 272119DEST_PATH_IMAGE002
860g of autumn pears in the steps; first, the
Figure 647736DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 140 g; first, the
Figure 255304DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 70 g; first, the
Figure 727874DEST_PATH_IMAGE010
The lily in the step is 55g, and the coltsfoot flower is 55 g; first, the
Figure 779006DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 704237DEST_PATH_IMAGE002
700g of autumn pears are adopted in the steps; first, the
Figure 554644DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the steps is 80 g; first, the
Figure 616141DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 90 g; first, the
Figure 87442DEST_PATH_IMAGE010
60g of lily and 40g of coltsfoot flower in the steps; first, the
Figure 499969DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 465651DEST_PATH_IMAGE002
750g of autumn pears in the steps; first, the
Figure 647233DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 130 g; first, the
Figure 525322DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 85 g; first, the
Figure 425145DEST_PATH_IMAGE010
60g of lily and 40g of coltsfoot flower in the steps; first, the
Figure 928938DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
Description of the invention
Figure 230607DEST_PATH_IMAGE004
In the step, water is added into the separated pear residues twice of the pear residues, and then the pear residues are decocted for 1 hour; first, the
Figure 778132DEST_PATH_IMAGE006
In the step, 40% ethanol is used for percolation, and 4 times of percolate is collected; first, the
Figure 165251DEST_PATH_IMAGE008
In the step, 30% ethanol is used for percolation, and 4 times of percolate is collected; first, the
Figure 472735DEST_PATH_IMAGE010
In the step, lily and coltsfoot flowerDecocting with water for three times, wherein the water amount is 6 times, 4 times and 4 times of the amount of lily and coltsfoot flower respectively, and the decocting time is 2 hours, 1 hour and 1 hour respectively; and standing for 24 hours.
The main effective component of the fritillaria cirrhosa is alkaloid and contains more starch, the alkaloid can be extracted by adopting a decoction method, but the ineffective component starch can be extracted at the same time, the extracting solution is pasty and is not beneficial to refining the effective component, the main component alkaloid can be extracted by adopting an ethanol percolation method, and the starch can not be extracted basically. The inventor compares the extracting solutions prepared by different ethanol concentrations (5-100%) with the extracting solution of the bulbus fritillariae cirrhosae prepared by a water boiling method in the test process, the difference between the viscosity and the content of the effective components is large after the viscosity is measured, the extracting solution obtained by a 40% ethanol percolation method has low viscosity, is beneficial to refining, and has high content of the effective components, namely alkaloid.
The radix Ophiopogonis contains saponin as main component and large amount of mucus as ineffective component, and if it is extracted by water decoction, large amount of mucus will be extracted, and the liquid medicine is viscous and difficult to concentrate and refine. In the test process, the inventor compares the ophiopogonin extracting solution prepared by different ethanol concentrations (5-100%) with the ophiopogonin extracting solution prepared by a water boiling method, and tests show that the difference between the mucilage and the effective component content is large, the extracting solution obtained by a 30% ethanol percolation method has low viscosity and is beneficial to refining, and the content of the effective component saponin is high.
The impurities of the lily and the coltsfoot flower are still more after water extraction, and the purity of the effective components can be improved after water extraction and alcohol precipitation.
The invention mainly solves the technical problems that: the problem that the product tastes too sweet and greasy is solved; solves the problems that the product has too viscous property and is difficult to take because the product is almost semisolid when the temperature is low in winter; the extraction process of the pear clear paste is optimized; solves the problem of extracting the effective components of the bulbus fritillariae cirrhosae and the radix ophiopogonis in the prescription; extracting alkaloid effective components from Bulbus Fritillariae Cirrhosae with 40% ethanol by percolation; extracting radix Ophiopogonis total saponin from radix Ophiopogonis with 30% ethanol by percolation; the lily and the coltsfoot flower adopt a water extraction and alcohol precipitation method to remove impurity components, so that the effective components are purer.
Compared with the prior art, the invention has the following technical advantages:
1. the effective components in the bulbus fritillariae cirrhosae are extracted, and the extraction of ineffective components is avoided: the main effective component of the bulbus fritillariae cirrhosae is alkaloid, and simultaneously contains more starch, although the alkaloid can be extracted by adopting a decoction method, the ineffective component starch can be extracted in a large amount, the extracting solution is pasty and is not beneficial to refining the effective component, the main component alkaloid can be extracted by adopting an ethanol percolation method, and the starch cannot be extracted basically;
2. the effective components in the ophiopogon root are extracted, and the extraction of ineffective components is avoided: the radix Ophiopogonis contains saponin as main component and large amount of mucus as ineffective component, and if the extract is extracted by water decoction, large amount of mucus can be extracted, and the medicinal liquid is viscous and difficult to concentrate and refine;
3. the impurities of the lily and the coltsfoot flower are still more after water extraction, and the purity of the effective components can be improved after water extraction and alcohol precipitation;
4. the product has improved properties and taste.
Detailed Description
Example 1:
the autumn pear syrup is prepared from fructus Pyri, Bulbus Fritillariae Cirrhosae, radix Ophiopogonis, Bulbus Lilii, flos Farfarae, maltose, and Mel;
the preparation method comprises the following steps: cleaning 800g of autumn pear, placing into a juicer, mincing, collecting pear juice, decocting pear residue with 2 times of water for 1 hr, filtering, mixing filtrate with pear juice, and concentrating under reduced pressure to obtain pear extract with relative density of 1.30 (50 deg.C); pulverizing Bulbus Fritillariae Cirrhosae 50g into coarse powder, percolating with 40% ethanol, collecting percolate 4 times, and recovering ethanol under reduced pressure; rolling 100g of radix ophiopogonis into flat pieces, percolating the flat pieces with 30% ethanol, collecting 4 times of percolate, and recovering ethanol under reduced pressure; decocting 60g of lily and 20g of coltsfoot flower with water for three times, wherein the water amount is 6 times, 4 times and 4 times, the decocting time is 2 hours, 1 hour and 1 hour respectively, filtering, combining with the recovery liquid of the bulbus fritillariae cirrhosae and the radix ophiopogonis, concentrating under reduced pressure to obtain clear paste with the relative density of 1.30 (50 ℃), and uniformly heating and mixing with the pear clear paste and 300g of maltose; adding 100g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
Example 2:
the autumn pear syrup is prepared from fructus Pyri, Bulbus Fritillariae Cirrhosae, radix Ophiopogonis, Bulbus Lilii, flos Farfarae, maltose, and Mel;
the preparation method comprises the following steps: cleaning 400g of autumn pear, placing into a juicer, mincing, collecting pear juice, decocting pear residue with 2 times of water for 1 hr, filtering, mixing filtrate with pear juice, and concentrating under reduced pressure to obtain pear extract with relative density of 1.30 (50 deg.C); pulverizing 160g of Bulbus Fritillariae Cirrhosae into coarse powder, percolating with 40% ethanol, collecting percolate of 4 times, and recovering ethanol under reduced pressure; rolling 40g of radix ophiopogonis into flat pieces, percolating the flat pieces with 30% ethanol, collecting 4 times of percolate, and recovering ethanol under reduced pressure; decocting 20g of lily and 60g of coltsfoot flower with water for three times, wherein the water amount is 6 times, 4 times and 4 times, the decocting time is 2 hours, 1 hour and 1 hour respectively, filtering, combining with the recovery liquid of the bulbus fritillariae cirrhosae and the radix ophiopogonis, concentrating under reduced pressure to obtain clear paste with the relative density of 1.30 (50 ℃), and uniformly heating and mixing with the pear clear paste and 300g of maltose; adding 100g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
Example 3:
the autumn pear syrup is prepared from fructus Pyri, Bulbus Fritillariae Cirrhosae, radix Ophiopogonis, Bulbus Lilii, flos Farfarae, maltose, and Mel;
the preparation method comprises the following steps: cleaning 700g of autumn pear, placing the autumn pear into a juicer for mincing, collecting pear juice, adding 2 times of water into pear residues for decocting for 1 hour, filtering, combining the filtrate and the pear juice, and concentrating under reduced pressure to obtain pear clear paste with the relative density of 1.30 (50 ℃); pulverizing Bulbus Fritillariae Cirrhosae 140g into coarse powder, percolating with 40% ethanol, collecting percolate 4 times, and recovering ethanol under reduced pressure; rolling 70g of radix ophiopogonis into flat pieces, percolating the flat pieces with 30% ethanol, collecting 4 times of percolate, and recovering ethanol under reduced pressure; decocting 55g of lily and 55g of coltsfoot flower with 6 times, 4 times and 4 times of water for 2 hours, 1 hour and 1 hour respectively, filtering, mixing with the recovery liquid of bulbus fritillariae cirrhosae and radix ophiopogonis, concentrating under reduced pressure to obtain fluid extract with relative density of 1.30 (50 ℃), and uniformly mixing with the pear fluid extract and 300g of maltose; adding 100g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
Example 4:
the autumn pear syrup is prepared from fructus Pyri, Bulbus Fritillariae Cirrhosae, radix Ophiopogonis, Bulbus Lilii, flos Farfarae, maltose, and Mel;
the preparation method comprises the following steps: cleaning 600g of autumn pear, placing in a juicer, mincing, collecting pear juice, decocting pear residue with 2 times of water for 1 hr, filtering, mixing filtrate with pear juice, and concentrating under reduced pressure to obtain pear extract with relative density of 1.30 (50 deg.C); pulverizing 80g Bulbus Fritillariae Cirrhosae into coarse powder, percolating with 40% ethanol, collecting percolate of 4 times, and recovering ethanol under reduced pressure; rolling 90g of radix ophiopogonis into flat pieces, percolating the flat pieces with 30% ethanol, collecting 4 times of percolate, and recovering ethanol under reduced pressure; decocting 60g of lily and 40g of coltsfoot flower with water for three times, wherein the water amount is 6 times, 4 times and 4 times, the decocting time is 2 hours, 1 hour and 1 hour respectively, filtering, combining with the recovery liquid of the bulbus fritillariae cirrhosae and the radix ophiopogonis, concentrating under reduced pressure to obtain clear paste with the relative density of 1.30 (50 ℃), and uniformly heating and mixing with the pear clear paste and 300g of maltose; adding 100g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
Example 5:
the autumn pear syrup is prepared from fructus Pyri, Bulbus Fritillariae Cirrhosae, radix Ophiopogonis, Bulbus Lilii, flos Farfarae, crystal sugar, and Mel;
the preparation method comprises the following steps: cleaning 750g autumn pears, placing the autumn pears in a juicer for mincing, collecting pear juice, adding 2 times of water into pear residues for decocting for 1 hour, filtering, combining the filtrate and the pear juice, and concentrating under reduced pressure to obtain pear clear paste with the relative density of 1.30 (50 ℃); pulverizing 130g of Bulbus Fritillariae Cirrhosae into coarse powder, percolating with 58% ethanol, collecting percolate of 4 times, and recovering ethanol under reduced pressure; rolling 85g of radix Ophiopogonis, percolating with 30% ethanol, collecting percolate 4 times, and recovering ethanol under reduced pressure; decocting 55g of lily and 50g of coltsfoot flower with 6 times, 4 times and 4 times of water for 2 hours, 1 hour and 1 hour respectively, filtering, mixing with the recovery liquid of bulbus fritillariae cirrhosae and radix ophiopogonis, concentrating under reduced pressure to obtain fluid extract with relative density of 1.30 (50 ℃), and uniformly mixing with the pear fluid extract and 300g of maltose; adding 100g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
Clinical data:
general data were admitted to 120 bronchitis infants, of which n =54 men and n =66 women; the minimum age is 8 years and the maximum age is 50 years. The clinical symptoms are fever, cough, expectoration, asthma, anorexia, poor sleep and the like. Physical examination: the throat congestion is obvious, the respiratory sound of both lungs is coarse, phlegm and (or) asthma are audible, 120 cases of the cough and expectoration, 87 cases of fever, 15 cases of asthma and 6 cases of nausea and vomiting are randomly divided into a treatment group and a control group, and the difference of the disease degree, the sex and the age of the two groups is not significant.
Treatment method the treatment group takes 5ml of autumn pear syrup of the invention example 1 every time and three times, the control group takes 5ml of phlegm-resolving and cough-relieving syrup for children every time and three times a day, and 1 treatment course is formed in one week for both groups.
The therapeutic effect standard observes the changes of body temperature, cough, expectoration and lung physical signs before and after treatment and judges the drug effect standard. (1) And (3) healing: the treatment lasts for 7 days, the body temperature is normal, cough symptoms disappear, phlegm and sound of the lung are removed, wheezing sound disappears, and the appetite is recovered; (2) the effect is shown: the body temperature is normal, the cough symptom is obviously relieved, the phlegm and the wheezing sound of the two lungs are obviously reduced, and the appetite is recovered earlier; (3) the method has the following advantages: body temperature drops, cough symptoms are relieved, the sound of both lungs is reduced, but the appetite is still poor; (4) and (4) invalidation: fever, cough and other main symptoms, the treatment course is more than 3 days without obvious improvement, the body temperature is reduced to less than 1 ℃, and the disease condition is aggravated or other general symptoms are accompanied.
Treatment results (1) statistics of symptom disappearance after two weeks treatment are shown in table 1.
Figure DEST_PATH_IMAGE014
(2) The statistical treatment results of the two groups after two treatment courses are shown in Table 2.
TABLE 2 two groups of treatment after two weeks of statistical efficacy
Figure DEST_PATH_IMAGE016
As can be seen from Table 2, the cure rate and the total effective rate of the two groups are significantly different (P < 0.5).
No one of the adverse reaction treatment groups had adverse reactions, 8 of the control groups had adverse reactions, 2 of the adverse reactions had anaphylactic reactions, which are marked by chills and high fever, and symptoms were relieved after intravenous injection of dexamethasone, and 3 of the adverse reactions had rash, and symptoms were relieved after oral administration of chlorpheniramine.
Has effects of moistening lung, relieving cough, promoting fluid production, and relieving sore throat, and can be used for treating cough with short breath, less phlegm, sticky texture, dry mouth and throat, and laryngalgia and hoarseness caused by yin deficiency and lung heat.
In a specific embodiment, the invention optimizes the components of the autumn pear syrup, the effect of example 5 is better than that of examples 3-4, and is further better than that of examples 1-2, and the efficacy of the autumn pear syrup described in example 1 is given in clinical data.

Claims (10)

1. A preparation method of autumn pear lung moistening paste is characterized by comprising the following steps:
Figure DEST_PATH_IMAGE002
cleaning autumn pears, placing the autumn pears in a juicer for mincing, extruding and centrifuging at a high speed to separate pear juice from pear residues, and collecting the pear juice for later use;
Figure DEST_PATH_IMAGE004
decocting the separated pear residues with water twice of the pear residues, centrifuging, mixing the supernatant with pear juice, and concentrating under reduced pressure to obtain pear extract with relative density of 1.30;
Figure DEST_PATH_IMAGE006
pulverizing Bulbus Fritillariae Cirrhosae into coarse powder, percolating with ethanol, collecting percolate, and recovering ethanol under reduced pressure;
Figure DEST_PATH_IMAGE008
rolling radix Ophiopogonis, percolating with ethanol, collecting percolate, and recovering ethanol under reduced pressure;
Figure DEST_PATH_IMAGE010
decocting Bulbus Lilii and flos Farfarae in water for three times; centrifuging, concentrating the supernatant under reduced pressure to relative density of 1.25Cooling to room temperature, adding ethanol to make ethanol content reach 60%, standing, collecting supernatant, mixing with percolate of Bulbus Fritillariae Cirrhosae and radix Ophiopogonis, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.30 containing Bulbus Lilii, flos Farfarae, Bulbus Fritillariae Cirrhosae and radix Ophiopogonis;
Figure DEST_PATH_IMAGE012
mixing the fluid extracts with fructus Pyri fluid extract and maltose syrup to obtain mixed fluid extract; adding 50g of old honey into every 100g of the mixed clear paste, and uniformly mixing to obtain the traditional Chinese medicine.
2. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 237133DEST_PATH_IMAGE002
The autumn pears in the step are 400-800 g; first, the
Figure 154274DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the steps is 50-160 g; first, the
Figure 871694DEST_PATH_IMAGE008
The ophiopogon root in the step is 40-100 g; first, the
Figure 266903DEST_PATH_IMAGE010
The lily in the step is 20-60g, and the coltsfoot flower is 20-60 g; first, the
Figure 81275DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
3. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 592153DEST_PATH_IMAGE002
The autumn pears in the step are 500-700 g; first, the
Figure 859187DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the steps is 80-140 g; first, the
Figure 995770DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 60-130 g; first, the
Figure 664649DEST_PATH_IMAGE010
25-50g of lily and 25-55g of coltsfoot flower in the steps; first, the
Figure 658013DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
4. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 599293DEST_PATH_IMAGE002
The autumn pears in the step are 550 g; first, the
Figure 336304DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 130 g; first, the
Figure 797373DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 85 g; first, the
Figure 227217DEST_PATH_IMAGE010
The lily in the step is 55g, and the coltsfoot flower is 50 g; first, the
Figure 157258DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
5. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 432382DEST_PATH_IMAGE002
The autumn pears in the steps are 800 g; first, the
Figure 75853DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 50 g; first, the
Figure 348702DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 100 g; first, the
Figure 77624DEST_PATH_IMAGE010
The lily in the step is 60g, and the coltsfoot flower is 20 g; first, the
Figure 343389DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
6. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 841366DEST_PATH_IMAGE002
400g of autumn pears in the steps; first, the
Figure 550696DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (b) is 160 g; first, the
Figure 501335DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 40 g; first, the
Figure 383840DEST_PATH_IMAGE010
The lily in the step is 20g, and the coltsfoot flower is 60 g; first, the
Figure 424740DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
7. An autumn festival according to claim 1The preparation method of the pear lung-moistening paste is characterized by comprising the following steps: the first mentioned
Figure 367288DEST_PATH_IMAGE002
860g of autumn pears in the steps; first, the
Figure 742905DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 140 g; first, the
Figure 163522DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 70 g; first, the
Figure 823043DEST_PATH_IMAGE010
The lily in the step is 55g, and the coltsfoot flower is 55 g; first, the
Figure 936492DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
8. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 861723DEST_PATH_IMAGE002
700g of autumn pears are adopted in the steps; first, the
Figure 23714DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the steps is 80 g; first, the
Figure 85211DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 90 g; first, the
Figure 57977DEST_PATH_IMAGE010
60g of lily and 40g of coltsfoot flower in the steps; first, the
Figure 470504DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
9. The preparation method of the autumn pear lung-moistening paste according to claim 1, characterized in that: the first mentioned
Figure 498503DEST_PATH_IMAGE002
750g of autumn pears in the steps; first, the
Figure 617769DEST_PATH_IMAGE006
The bulbus fritillariae cirrhosae in the step (1) is 130 g; first, the
Figure 807442DEST_PATH_IMAGE008
The dwarf lilyturf tuber in the step is 85 g; first, the
Figure 707264DEST_PATH_IMAGE010
60g of lily and 40g of coltsfoot flower in the steps; first, the
Figure 460326DEST_PATH_IMAGE012
The amount of maltose syrup in step (a) was 300 g.
10. A method of preparing any of the autumn pear lung-moistening pastes of claims 1-9, characterized in that: the first mentioned
Figure 761994DEST_PATH_IMAGE004
In the step, water is added into the separated pear residues twice of the pear residues, and then the pear residues are decocted for 1 hour; first, the
Figure 60251DEST_PATH_IMAGE006
In the step, 40% ethanol is used for percolation, and 4 times of percolate is collected; first, the
Figure 447370DEST_PATH_IMAGE008
In the step, 30% ethanol is used for percolation, and 4 times of percolate is collected; first, the
Figure 493869DEST_PATH_IMAGE010
In the step, the lily and the coltsfoot flower are decocted for three times by adding water, the water amount is respectively 6 times, 4 times and 4 times of the amount of the lily and the coltsfoot flower, and the decocting time is respectively 2 hours, 1 hour and 1 hour; and standing for 24 hours.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266479A (en) * 2010-06-02 2011-12-07 襄樊隆中药业有限责任公司 Fritillary and snow pear particle and preparation method thereof
CN104435944A (en) * 2014-12-24 2015-03-25 刘安利 Traditional Chinese medicine composition for treating infantile cough and preparation method thereof
CN105288134A (en) * 2015-11-24 2016-02-03 葵花药业集团湖北武当有限公司 Preparation method of pear paste for moistening lung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266479A (en) * 2010-06-02 2011-12-07 襄樊隆中药业有限责任公司 Fritillary and snow pear particle and preparation method thereof
CN104435944A (en) * 2014-12-24 2015-03-25 刘安利 Traditional Chinese medicine composition for treating infantile cough and preparation method thereof
CN105288134A (en) * 2015-11-24 2016-02-03 葵花药业集团湖北武当有限公司 Preparation method of pear paste for moistening lung

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Application publication date: 20200821