CN112972586A

CN112972586A - Chinese herbal medicine composition preparation for treating hyperuricemia through fermentation of myxomycete and preparation method

Info

Publication number: CN112972586A
Application number: CN202110356237.3A
Authority: CN
Inventors: 戴陵江; 谢立克; 樊萍
Original assignee: Jiangsu Chunjiang Biotechnology Co ltd
Current assignee: Jiangsu Chunjiang Biotechnology Co ltd
Priority date: 2021-04-01
Filing date: 2021-04-01
Publication date: 2021-06-18

Abstract

The invention discloses a combined preparation for treating hyperuricemia by fermenting Chinese herbal medicines by the year of the third year and a preparation method thereof, belonging to the technical field of bioengineering and fermentation; the Chinese herbal medicines such as chicory root, cape jasmine, kudzu root, plantain herb, eucommia bark, rehmannia root, mulberry leaf, lily, dandelion and the like are used as main raw materials, a sugar source, water and a myxomycete composite bacterial liquid are used as auxiliary materials, the Chinese herbal medicines are cultured in a fermentation tank at the temperature of 26 ℃ for 10-15 days, the pH value is 5-7.5, the medicinal components of the Chinese herbal medicines are released to the maximum, PQQ, nucleotide, chitin, flavone, polysaccharide, glutathione, saponin and other active substances metabolized in the fermentation process of myxomycete are added, the metabolism of uric acid is enhanced through the medicinal components of the Chinese herbal medicines released after fermentation, toxins in blood and redundant harmful substances such as uric acid can be removed, the immunity of a human body can be enhanced through the fungal polysaccharide, PQQ and other active substances, damaged islet cells and tissues can be repaired, and the remarkable curative effect.

Description

Chinese herbal medicine composition preparation for treating hyperuricemia through fermentation of myxomycete and preparation method

Technical Field

The invention relates to the technical field of bioengineering and fermentation, in particular to a Chinese herbal medicine composition preparation for treating hyperuricemia through fermentation of the pacific year and a preparation method thereof.

Background

Hyperuricemia is a metabolic disease caused by the fact that a substance called purine is metabolized and disordered in a human body, so that uric acid in blood is increased. Uric acid rises because it hinders the process of blood secreting uric acid, making uric acid impossible to discharge. Other diseases can also be caused by over-high uric acid. In recent ten years, not only the middle-aged and elderly people get ill, but also the trend of the youth appears, and the disease becomes a common disease. The existing drugs for treating hyperuricemia have limited effectiveness and poor healing effect, so new drugs need to be developed.

Disclosure of Invention

The invention aims to provide a Chinese herbal medicine composition preparation for treating hyperuricemia through fermentation in the age of the taisui and a preparation method thereof, and aims to solve the problem that the healing effect of the existing medicine for treating hyperuricemia is poor.

In order to achieve the above objects, in a first aspect, the present invention provides a Chinese herbal medicine composition for treating hyperuricemia by fermentation in the age of pacific, wherein the composition comprises the following components by weight: 15g of chicory root, 10g of cape jasmine, 20g of kudzu root, 15g of plantain herb, 10g of eucommia bark, 5g of rehmannia root, 5g of mulberry leaf, 10g of lily, 5g of dandelion and 100ml to 150ml of myxomycete composite bacterial liquid.

In a second aspect, the invention also provides a preparation method of a Chinese herbal medicine composition preparation for treating hyperuricemia through fermentation in the age of pacific, comprising the following steps:

processing various raw materials according to a proportion;

preparing a composite bacterium liquid for the pacific year;

putting all raw materials into a fermentation tank, adding 50ml of edible fructose, adding 100ml to 150ml of myxomycete composite bacterial liquid, adding water, and keeping the pH value to be 5 to 5.7;

sealing and fermenting the fermentation tank for 10-15 days, wherein the pH value is 3-3.5, and finishing the fermentation;

filtering the residue to obtain the combined preparation.

Wherein, the filtration of the residue to prepare the combined preparation further comprises: the combined preparation is pasteurized and then added with honey.

Wherein the raw materials comprise, by weight: 15g of chicory root, 10g of cape jasmine, 20g of kudzu root, 15g of plantain herb, 10g of eucommia bark, 5g of rehmannia root, 5g of mulberry leaf, 10g of lily and 5g of dandelion.

The method comprises the following specific steps of treating various raw materials in proportion: washing the raw material with tap water; cleaning the raw materials with purified water for 2 times; soaking the mixture for 30 minutes by using a solution with the mass concentration of 10 g/LNaCl; and (5) draining and crushing for later use.

The preparation method of the myxomycete liquid comprises the following specific steps: adding 50ml of stock solution of the pacific year into a fermentation tank; adding 400ml of mineral water and 500ml of edible fructose into a fermentation tank; culturing at 26 deg.C for 10 days to obtain 500ml compound bacterium solution.

Wherein the residue is filtered to prepare the combined preparation by the specific steps of: coarsely filtering and screening the residues by adopting a sieve with 20-30 meshes; and further filtering the residue by adopting a 150-200 mesh sieve.

The invention relates to a combined preparation for treating hyperuricemia by fermenting Chinese herbal medicines in the age of Taisui and a preparation method thereof. After the medicine is continuously taken for 15 days, metabolic diseases such as gout, hyperuricemia and the like have obvious curative effects. A plurality of clinical tests show that the effective rate of the preparation for treating gout and hyperuricemia is 100%, the Chinese herbal medicine components released after fermentation can mainly enhance the metabolism of uric acid in vivo, can remove toxin and redundant uric acid in blood, and active substances such as fungal polysaccharide, PQQ and the like can enhance the immunity of human bodies and repair damaged cells and tissues. Clinical tests show that tens of patients take the fermented preparation a little, and the fermented preparation has obvious curative effect on treating hyperuricemia, wherein the effective rate is 100%, and the cure rate is more than 90%.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a flow chart of a method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the age of Taisui according to the present invention;

FIG. 2 is a flow chart of the present invention for processing various raw materials in scale;

FIG. 3 is a flow chart of the present invention for preparing a composite bacterial liquid for the pacific year;

FIG. 4 is a flow chart of the present invention for filtering the residue to obtain a combined preparation.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.

In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, and are used merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. Further, in the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In a first aspect, the invention provides a Chinese herbal medicine composition preparation for treating hyperuricemia by fermenting the pacific years, which comprises the following components in parts by weight: 15g of chicory root, 10g of cape jasmine, 20g of kudzu root, 15g of plantain herb, 10g of eucommia bark, 5g of rehmannia root, 5g of mulberry leaf, 10g of lily, 5g of dandelion and 100ml to 150ml of myxomycete composite bacterial liquid.

In the present embodiment, chicory root (Cichorium glandulosum Boiss) refers to a medicinal material that is used conventionally by Uygur nationality. Chicory has the functions of regulating blood fat and reducing uric acid, has good regulating effect on hyperuricemia, and can obviously improve hyperuricemia and abdominal obesity caused by high purine diet. The action mechanism of the compound can reduce the activity of liver acetyl coenzyme A carboxylase, fatty acid synthetase and xanthine oxidase, thereby playing a role in comprehensively regulating uric acid and abdominal fat accumulation.

Gardenia jasminoides Ellis (academic name: Gardeniajasminoides Ellis): gardenia jasminoides Ellis, Gardenia jasminoides Ellis and Cinobufagin are fruits of Gardenia jasminoides Ellis of Rubiaceae. The fruit of gardenia is a traditional Chinese medicine, belongs to the first batch of medical and edible dual-purpose resources issued by the Ministry of health, and has the functions of protecting liver, benefiting gallbladder, reducing blood pressure, calming, stopping bleeding, reducing swelling and the like. Is used for treating icteric hepatitis, sprain, contusion, hypertension, diabetes and other diseases in traditional Chinese medicine clinic.

Kudzu root, name of Chinese traditional medicine. Is dried root of Pueraria lobata Ohwi of Leguminosae, commonly known as Pueraria lobata Ohwi. Collected in autumn and winter, and cut into thick slices or small blocks when fresh; and (5) drying. Sweet, pungent and cool. Has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea. It is commonly indicated for exterior syndrome with fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging and diarrhea due to spleen deficiency.

Plantago asiatica, academic name Plantago depressa Willd. Annual or biennial herbs. The herba plantaginis is whole plant of herba plantaginis and herba Plantago Plantaginaceae, and has sweet taste and cold property. Has effects of promoting urination, clearing heat away, improving eyesight, eliminating phlegm, and smoothing plantago. Can be used for treating urinary obstruction, stranguria with turbid urine, leukorrhagia, hematuria, jaundice, edema, dysentery, diarrhea, epistaxis, conjunctival congestion, sore throat, cough, skin ulcer, etc.

Eucommia ulmoides (academic name Eucommia ulmoides Oliver), also called Bakelite, is a plant of genus Eucommia of family Eucommiaceae. The first book of Chinese herbs, Shennong Ben Cao Jing, records the drug effect of eucommia ulmoides, and Li Shizhen is pointed out in Ben Cao gang mu: "Xishu Du, the name is because it is administrated with eucommia bark. The Eucommiae cortex has bidirectional regulating effect for treating blood pressure, and can be used for preventing space osteoporosis and preventing aging.

Rehmannia (the name of Latin science: Rehmannia glutinosa (Gaetn.) Libosch. ex Fisch. etMey.) and perennial herb of Rehmannia of Scrophulariaceae have cool nature and sweet and bitter taste, and have the effects of nourishing yin and tonifying kidney, nourishing blood and enriching blood and cooling blood. It is beneficial to be taken by patients with yin deficiency, blood deficiency and kidney deficiency. In addition, rehmanniae radix has effects of tonifying heart, promoting diuresis, relieving fever, relieving inflammation, promoting blood coagulation and reducing blood sugar.

Mulberry Leaf, (Mulberry Leaf), scientific name: a Folium mori. The Chinese medicine is dry leaf of Morus alba L of Moraceae, and is used as main food of silkworm, and is also named as mulberry, Nervilia, Mori fructus, and folium Mori. The folium Mori is dry leaf of Morus alba L of Moraceae. Collected after blooming, removed of impurities and dried in the sun, is a wind-heat dispersing medicine which can be taken orally or applied externally. [3] It is cold in nature, sweet and bitter in taste, has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight, and can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight. In modern Chinese and Western medicine, mulberry leaf and its biological preparation are used as medicine for improving diabetes and other various difficult and complicated diseases. Has effects in clearing away lung heat, moistening dryness, relieving cough, removing heat, eliminating phlegm, and treating night sweat; nourishing liver, removing liver fire, improving eyesight, treating dizziness and insomnia, and relieving eye fatigue; detumescence and blood-cleaning for treating dysentery and abdominal pain, reducing weight, removing loempe, benefiting large intestine and small intestine; anti-stress, cooling blood, lowering blood pressure, reducing blood lipid, preventing myocardial infarction and cerebral hemorrhage, relieving headache, and promoting hair growth; reducing blood sugar, resisting diabetes, etc.

Lily is known as Lilium brownii var. viridulum Baker, also known as Qiangshu, folium Allii tuberosi, Shandan, Fanxian, Dahlimai, Zhongting, Mo Rou, double box, Zhongmeihua, Lily garlic, Dashifu garlic, garlic bulb potato, evening primrose, etc. Has the main functions of nourishing yin and moistening lung; clearing away heart-fire and tranquilizing. Chronic cough due to yin deficiency; blood in sputum; late stage of febrile disease; restlessness, pavor, insomnia, dreaminess and absentmindedness due to residual heat or emotional disorder; abscess and swelling; and (4) eczema.

Taraxacum mongolicum hand-Mazz (Latin name) Taraxacum mongolicum hand-Mazz (Taraxacum mongolicum hand-Mazz.) Compositae, Taraxacum perennial herbaceous plant. The functional indications are as follows: clear heat and remove toxicity, induce diuresis and dissipate nodulation. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.

Taisui is called meat ganoderma lucidum in the traditional Chinese medicine theory. The said aged people are rich in 46 active substances and nutrients necessary for human body, such as PQQ (pyrroloquinoline quinone), nucleotide, chitin, flavone, polysaccharide, glutathione, saponin, chitin, unsaturated fatty acid, SOD, trace elements, amino acids, etc. Has special effects of resisting tumor, resisting aging, enhancing immunity, etc.

The Chinese herbal medicines such as chicory root, cape jasmine, kudzu root, plantain herb, eucommia bark, rehmannia root, mulberry leaf, lily, dandelion and the like are used as main raw materials, the stock solution of the Taisui is used for fermentation, so that medicinal ingredients of the Chinese herbal medicines are released to the maximum extent, enzymes and a plurality of active substances are generated, the active substances such as PQQ, nucleotide, chitin, flavone, polysaccharide, glutathione, saponin and the like metabolized in the fermentation process of the Taisui are added, the metabolism of uric acid is enhanced by the medicinal ingredients of the Chinese herbal medicines released after fermentation, the toxic substances such as toxin in blood and redundant uric acid and the like can be removed, the active substances such as fungal polysaccharide, PQQ and the like can enhance the immunity of a human body, damaged islet cells and tissues are repaired, and the Chinese herbal medicines have obvious. The invention has the advantages of short fermentation time, rich medicinal components of the Chinese herbal medicines, more active substances and the like. The raw materials used in the product are both edible and medicinal, the fermentation strains are probiotics, and the finished product is detected by the national food and medicine administration department, reaches the food safety standard, can be taken for a long time and is harmless to human bodies.

In a second aspect, referring to fig. 1-4, the present invention further provides a method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the third year, comprising:

s101, processing various raw materials in proportion;

the raw materials comprise the following components in parts by weight: 15g of chicory root, 10g of cape jasmine, 20g of kudzu root, 15g of plantain herb, 10g of eucommia bark, 5g of rehmannia root, 5g of mulberry leaf, 10g of lily and 5g of dandelion.

The method comprises the following specific steps:

s201, washing the raw material by tap water;

the first cleaning with tap water can reduce the amount of purified water to reduce the manufacturing cost.

S202, cleaning the raw materials for 2 times by using purified water;

washing with purified water for 2 times can remove fine impurities and attached tap water, so that the material has higher purity.

S203, soaking for 30 minutes by using a solution with the mass concentration of 10 g/LNaCl;

the drug effect of various raw materials can be enhanced after the raw materials are soaked in NaCl solution.

And S204, draining and crushing for later use.

The contact area between the raw material and liquid can be increased after the raw material is crushed, so that the effective components in the raw material can be fully released.

S102, preparing a composite bacterium liquid for the pacific year;

the method comprises the following specific steps:

s301, adding 50ml of stock solution of the pacific year into a fermentation tank;

50ml of stock solution of the pacifier is measured and added into the fermentation tank.

S302, adding 400ml of mineral water and 500ml of edible fructose into a fermentation tank;

weighing 400ml mineral water and 500ml edible fructose, and adding into fermentation tank, wherein the mineral water is preferably Dongting mountain mineral water, and the preparation effect is better.

S303, culturing at the constant temperature of 26 ℃ for 10 days to obtain 500ml of compound bacterium liquid for the myxomycete;

setting the temperature of the fermentation tank at 26 ℃ and keeping the temperature constant, and culturing for 10 days to obtain 500ml of the compound bacterium liquid for the myxomycete.

S103, putting all raw materials into a fermentation tank, adding 50ml of edible fructose, adding 100ml to 150ml of myxomycete composite bacterial liquid, adding water, and keeping the pH value to be 5 to 5.7;

s104, sealing and fermenting the fermentation tank for 10-15 days, wherein the fermentation is finished when the pH value is 3-3.5;

s105, filtering the residue to prepare a combined preparation;

the method comprises the following specific steps:

s401, coarsely filtering and screening residues by using a 20-30-mesh sieve;

coarse filtering, and primarily screening large-particle residues.

S402, filtering the residue by adopting a 150-200 mesh sieve.

The small particle residues are further filtered, so that the liquid is in a clearer state.

S106 the combined preparation is added with honey after pasteurization.

The fermented preparation is pasteurized before oral administration, and is added with proper amount of honey for direct eating.

The fermentation method of the invention is not only beneficial to the extraction of the physiological active substances of the Chinese herbal medicines, but also enables the medicinal components of the Chinese herbal medicines to be released to the maximum, enzymes and a plurality of active substances are generated, various probiotics in the fermentation process of the pacific old can metabolize a plurality of active substances beneficial to the human body, and the stability of the effective medicinal components and the active substances of the traditional Chinese medicine is ensured. After the medicine is continuously taken for 15 days, metabolic diseases such as gout, hyperuricemia and the like have obvious curative effects. A plurality of clinical tests show that the effective rate of the preparation for treating gout and hyperuricemia is 100%, the Chinese herbal medicine components released after fermentation can mainly enhance the metabolism of uric acid in vivo, can remove toxin and redundant uric acid in blood, and active substances such as fungal polysaccharide, PQQ and the like can enhance the immunity of human bodies and repair damaged cells and tissues. Clinical tests show that tens of patients take the fermented preparation a little, and the fermented preparation has obvious curative effect on treating hyperuricemia, wherein the effective rate is 100%, and the cure rate is more than 90%.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. A Chinese herbal medicine composition preparation for treating hyperuricemia through fermentation of the pacific year, which is characterized in that,

the components are respectively as follows by weight: 15g of chicory root, 10g of cape jasmine, 20g of kudzu root, 15g of plantain herb, 10g of eucommia bark, 5g of rehmannia root, 5g of mulberry leaf, 10g of lily, 5g of dandelion and 100ml to 150ml of myxomycete composite bacterial liquid.

2. A preparation method of a Chinese herbal medicine composition for treating hyperuricemia through fermentation of the pacific years is applied to the Chinese herbal medicine composition for treating hyperuricemia through fermentation of the pacific years as claimed in claim 1, and is characterized in that:

the method comprises the following steps: processing various raw materials according to a proportion;

preparing a composite bacterium liquid for the pacific year;

filtering the residue to obtain the combined preparation.

3. The method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the age of Taisui as claimed in claim 2,

the filtration of the residue to produce the combined preparation further comprises: the combined preparation is pasteurized and then added with honey.

4. The method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the age of Taisui as claimed in claim 3,

5. The method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the age of Taisui as claimed in claim 4,

the specific steps for processing various raw materials in proportion are as follows:

washing the raw material with tap water;

cleaning the raw materials with purified water for 2 times;

soaking the mixture for 30 minutes by using a solution with the mass concentration of 10 g/LNaCl;

and (5) draining and crushing for later use.

6. The method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the age of Taisui as claimed in claim 5,

the preparation method of the myxomycete complex bacterium liquid comprises the following specific steps:

adding 50ml of stock solution of the pacific year into a fermentation tank;

adding 400ml of mineral water and 500ml of edible fructose into a fermentation tank;

culturing at 26 deg.C for 10 days to obtain 500ml compound bacterium solution.

7. The method for preparing a Chinese herbal medicine composition for treating hyperuricemia through fermentation in the age of Taisui as claimed in claim 6,

the residue is filtered to prepare the combined preparation, which comprises the following specific steps:

coarsely filtering and screening the residues by adopting a sieve with 20-30 meshes;

and further filtering the residue by adopting a 150-200 mesh sieve.