CN105288134B - Preparation method of pear paste for moistening lung - Google Patents
Preparation method of pear paste for moistening lung Download PDFInfo
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- CN105288134B CN105288134B CN201510820071.0A CN201510820071A CN105288134B CN 105288134 B CN105288134 B CN 105288134B CN 201510820071 A CN201510820071 A CN 201510820071A CN 105288134 B CN105288134 B CN 105288134B
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- fritillariae cirrhosae
- radix ophiopogonis
- bulbus fritillariae
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Abstract
The invention provides a preparation method of pear paste for moistening lung. A percolation method is employed to extract the alkaloid active ingredient in Bulbus Fritillariae Cirrhosae by using 58% ethanol; and the percolation method is employed to extract the ophiopogonin of ophiopogon root by using 30% ethanol. The method solves the problem of extraction of a large number of an invalid ingredient starch in the prior art of Bulbus Fritillariae Cirrhosae extraction, and is conducive to the refining of effective components, and solves the problem that the existing ophiopogon root boiling extraction method causes extraction of a large number of invalid ingredients mucilage, and the soup is very viscous and difficult to concentration and purification.
Description
Technical field
The invention belongs to technical field of Chinese medicines, is related to a kind of preparation method of autumn pear lung-nourishing semifluid extract.
Background technology
One to autumn, day dry gas is hot-tempered, and a series of seasonalities such as dry mouth and tougue, lung-heat excessive thirst easily occur in most people
Symptom.Work to patient and it is in life bring great inconvenience, severe patient can more cause respiratory passage diseases, if controlling not in time
Treat, the disease on the respiratory tracts such as chronic pharyngitiss will be caused, it is difficult to cure.
Autumn pear lung-nourishing semifluid extract nourishing the lung to arrest cough, secretion replenishing and throat moistening.For the cough shortness of breath that deficiency of YIN lung-heat causes, small amount of sputum sticky in nature, dry mouth
Dry pharynx, celostomia of having sore throat.
The content of the invention
It is an object of the invention to provide a kind of have nourishing the lung to arrest cough, the effect of secretion replenishing and throat moistening causes for deficiency of YIN lung-heat
Cough shortness of breath, small amount of sputum sticky in nature, dryness of the mouth and throat, have sore throat celostomia a kind of pure Chinese medicinal preparation.
Present invention mainly solves technical problem：The extraction of Bulbus Fritillariae Cirrhosae and Active Constituents of Ophiopogon Japonicus in prescription is solved the problems, such as,
With 58% ethanol, the alkaloid active ingredient in Bulbus Fritillariae Cirrhosae is extracted using percolation；With 30% ethanol, extracted using percolation
Radix Ophiopogonis total saponins in Radix Ophiopogonis.
Main active ingredient in Bulbus Fritillariae Cirrhosae is alkaloid, simultaneously containing more starch, although can also using decocting method
Alkaloid is extracted, but invalid element starch can be extracted in a large number simultaneously, and extracting solution in the pasty state, is unfavorable for the essence of active ingredient
System, is extracted using alcohol percolation method, then main composition alkaloid can be proposed into starch then will not be extracted substantially.Inventor is in examination
Different ethanol concentration is compared during testing（5%-100%）Bulbus Fritillariae Cirrhosae extracting solution prepared by the extracting solution of preparation, water-boiling method, Jing is surveyed
Fixed its viscosity and active constituent content differ greatly, and it is relatively low beneficial to refined, Er Qieyou that 58% alcohol percolation method gained extracts fluid viscosity
Effect ingredients Biogenic alkali content is higher.
Radix Ophiopogonis, Main Ingredients and Appearance was saponin, while and containing a large amount of invalid element phlegmatic temperaments, such as extracted with water-boiling method, a large amount of mucus
Matter can be suggested, and medicinal liquid is very sticky, it is difficult to which concentration is refined.Inventor compares different ethanol concentration in process of the test（5%-
100%）Radix Ophiopogonis extract prepared by the ophiopogonin extracting solution of preparation, water-boiling method, Jing determines its phlegmatic temperament and active constituent content
Differ greatly, 30% alcohol percolation method gained extracting solution viscosity is relatively low beneficial to refined, and effective ingredient saponin content is higher.
A kind of preparation method of autumn pear lung-nourishing semifluid extract of the present invention, it comprises the steps：Autumn pear is cleaned, and puts juice extractor
In blend, collect Sucus Pyri, the pears slag 4 times of decoctings measured that add water are boiled 1.5 hours, are filtered, and filtrate merges with Sucus Pyri, is evaporated to phase
It is 1.45 to density（50℃）Fructus Pyri thin paste；Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression
Reclaim ethanol.Radix Ophiopogonis, draw down, used 30% ethanol percolation, collected 6 times of percolates, decompression recycling ethanol；Bulbus Lilii, Flos Farfarae add decocting
Boil three times, the water yield is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, filter, filtrate and Bulbus Fritillariae Cirrhosae
Female, percolate Radix Ophiopogonis merges, and is evaporated to relative density for 1.45（50℃）Clear paste, after merging with above-mentioned Fructus Pyri thin paste plus
Mixing clear paste is made in crystal sugar 200g heating mixings, and old honey 100g is added per 100g mixing clear paste, mixes, and obtains final product.
The present invention has also been carried out preferably to autumn pear lung-nourishing semifluid extract component, and in a specific embodiment, the effect of embodiment 5 is better than real
A 3-4 is applied, further better than embodiment 1-2, the drug effect of autumn pear grease described in embodiment 1 is given in clinical data.
The present invention compared with prior art, with technical advantage as described below：
1st, the active ingredient being extracted in Bulbus Fritillariae Cirrhosae, it is to avoid the extraction of invalid element：Main active ingredient in Bulbus Fritillariae Cirrhosae
For alkaloid, simultaneously containing more starch, although can also extract alkaloid using decocting method, invalid element starch is simultaneously
Can be extracted in a large number, extracting solution in the pasty state, is unfavorable for the refined of active ingredient, is extracted using alcohol percolation method, then can be by master
Composition alkaloid proposes that starch then will not be extracted substantially.
2nd, the active ingredient being extracted in Radix Ophiopogonis, it is to avoid the extraction of invalid element：Radix Ophiopogonis, Main Ingredients and Appearance was saponin, while
Contain a large amount of invalid element phlegmatic temperaments again, such as extracted with water-boiling method, a large amount of phlegmatic temperaments can be suggested, and medicinal liquid is very sticky, it is difficult to dense
Contracting is refined.
Specific embodiment
Embodiment 1
Autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Bulbus Lilii, Flos Farfarae, crystal sugar, old processed with honey into；
Its preparation method comprises the steps：Take 800g autumn pears to clean, put in juice extractor and blend, collect Sucus Pyri, pears slag adds
The decocting of 4 times of amounts of water is boiled 1.5 hours, is filtered, and filtrate merges with Sucus Pyri, is evaporated to relative density for 1.45（50℃）Pears
Clear paste；Bulbus Fritillariae Cirrhosae 50g is ground into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；Radix Ophiopogonis, 100g rolled
It is flat, 30% ethanol percolation is used, collect 6 times of percolates, decompression recycling ethanol；Bulbus Lilii 60g, Flos Farfarae 20g add water to cook three times, water
Amount is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, and filtration, filtrate is oozed with Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis
Liquid of filtering merges, and is evaporated to relative density for 1.45（50℃）Clear paste, with crystal sugar 200g after merging with above-mentioned Fructus Pyri thin paste
Mixing clear paste is made in heating mixing, and old honey 100g is added per 100g mixing clear paste, mixes, and obtains final product.
Embodiment 2
Autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Bulbus Lilii, Flos Farfarae, crystal sugar, old processed with honey into；
Its preparation method comprises the steps：Take 400g autumn pears to clean, put in juice extractor and blend, collect Sucus Pyri, pears slag adds
The decocting of 4 times of amounts of water is boiled 1.5 hours, is filtered, and filtrate merges with Sucus Pyri, is evaporated to relative density for 1.45（50℃）Pears
Clear paste；Bulbus Fritillariae Cirrhosae 160g is ground into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；Radix Ophiopogonis, 40g rolled
It is flat, 30% ethanol percolation is used, collect 6 times of percolates, decompression recycling ethanol；Bulbus Lilii 20g, Flos Farfarae 60g add water to cook three times, water
Amount is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, and filtration, filtrate is oozed with Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis
Liquid of filtering merges, and is evaporated to relative density for 1.45（50℃）Clear paste, with crystal sugar 200g after merging with above-mentioned Fructus Pyri thin paste
Mixing clear paste is made in heating mixing, and old honey 100g is added per 100g mixing clear paste, mixes, and obtains final product.
Embodiment 3
Autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Bulbus Lilii, Flos Farfarae, crystal sugar, old processed with honey into；
Its preparation method comprises the steps：Take 700g autumn pears to clean, put in juice extractor and blend, collect Sucus Pyri, pears slag adds
The decocting of 4 times of amounts of water is boiled 1.5 hours, is filtered, and filtrate merges with Sucus Pyri, is evaporated to relative density for 1.45（50℃）Pears
Clear paste；Bulbus Fritillariae Cirrhosae 140g is ground into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；Radix Ophiopogonis, 70g rolled
It is flat, 30% ethanol percolation is used, collect 6 times of percolates, decompression recycling ethanol；Bulbus Lilii 55g, Flos Farfarae 55g add water to cook three times, water
Amount is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, and filtration, filtrate is oozed with Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis
Liquid of filtering merges, and is evaporated to relative density for 1.45（50℃）Clear paste, with crystal sugar 200g after merging with above-mentioned Fructus Pyri thin paste
Mixing clear paste is made in heating mixing, and old honey 100g is added per 100g mixing clear paste, mixes, and obtains final product.
Embodiment 4
Autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Bulbus Lilii, Flos Farfarae, crystal sugar, old processed with honey into；
Its preparation method comprises the steps：Take 800g autumn pears to clean, put in juice extractor and blend, collect Sucus Pyri, pears slag adds
The decocting of 4 times of amounts of water is boiled 1.5 hours, is filtered, and filtrate merges with Sucus Pyri, is evaporated to relative density for 1.45（50℃）Pears
Clear paste；Bulbus Fritillariae Cirrhosae 80g is ground into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；Radix Ophiopogonis, 90g rolled
It is flat, 30% ethanol percolation is used, collect 6 times of percolates, decompression recycling ethanol；Bulbus Lilii 60g, Flos Farfarae 40g add water to cook three times, water
Amount is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, and filtration, filtrate is oozed with Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis
Liquid of filtering merges, and is evaporated to relative density for 1.45（50℃）Clear paste, with crystal sugar 200g after merging with above-mentioned Fructus Pyri thin paste
Mixing clear paste is made in heating mixing, and old honey 100g is added per 100g mixing clear paste, mixes, and obtains final product.
Embodiment 5
Autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Bulbus Lilii, Flos Farfarae, crystal sugar, old processed with honey into；
Its preparation method comprises the steps：Take 750g autumn pears to clean, put in juice extractor and blend, collect Sucus Pyri, pears slag adds
The decocting of 4 times of amounts of water is boiled 1.5 hours, is filtered, and filtrate merges with Sucus Pyri, is evaporated to relative density for 1.45（50℃）Pears
Clear paste；Bulbus Fritillariae Cirrhosae 130g is ground into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；Radix Ophiopogonis, 85g rolled
It is flat, 30% ethanol percolation is used, collect 6 times of percolates, decompression recycling ethanol；Bulbus Lilii 55g, Flos Farfarae 50g add water to cook three times, water
Amount is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, and filtration, filtrate is oozed with Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis
Liquid of filtering merges, and is evaporated to relative density for 1.45（50℃）Clear paste, with crystal sugar 200g after merging with above-mentioned Fructus Pyri thin paste
Mixing clear paste is made in heating mixing, and old honey 100g is added per 100g mixing clear paste, mixes, and obtains final product.
Clinical data
Physical data is admitted to hospital 120 bronchitis infants, wherein man's n=54 examples, female's n=66 examples；Age is minimum 8 years old, maximum
50 years old.Clinical symptoms are heating, cough, expectoration, asthma, loss of appetite, sleep not good enough etc..Have a medical check-up：Pharyngeal hyperemia is obvious, double lungs
Respiratory murmur is thick, audible and rale sound and (or) sound of stridulating, wherein 120 have cough, expectoration, generates heat 87, pants 15, dislikes
The heart, vomiting 6, are randomly divided into treatment group and matched group, two groups of severity extents, sex, age equal no significant differences.
The autumn pear grease described in the embodiment of the present invention 1 is taken by Therapeutic Method treatment group, and each 5ml takes in three times, matched group
Oral xiao'er huatan zhike syrup, each 5ml, a day three times, two groups of homogeneous weeks are 1 course for the treatment of.
Criterion of therapeutical effect observe Temperature changing and cough, expectoration, physical signs of lung before the treatment after change and judge drug effect mark
It is accurate.(1) fully recover：Treatment 7 days, body temperature is normal, and cough symptom disappears, double lung rale sounds, and sound of stridulating disappears, and appetite is recovered；(2) show
Effect：Body temperature is normal, and cough symptom substantially mitigates, and double lung rale sounds, sound of stridulating are significantly reduced, appetite is recovered earlier above；(3) effectively：
Temperature decline, cough symptom mitigates, and double lungs sounds are reduced, but appetite is still poor；(4) it is invalid：The cardinal symptoms such as heating, cough, the course for the treatment of
It was not improved, 1 DEG C of temperature decline ＜ more than 3 days, aggravation or has other General Symptomies concurrently.
Symptom disappearance statistics is shown in Table 1 after (1) two group of therapeutic outcome controls two weeks.
The symptom of table 1 disappears and counts
（2）Two groups are treated after two courses for the treatment of, and curative effect statistics therapeutic outcome is shown in Table 2
Curative effect is counted after the treatment two weeks of 2 two groups of table
From Table 2, it can be seen that two groups of cure rates, total effective rates have significant difference (P ＜ 0.5).
There is untoward reaction in none infant for the treatment of group；There is untoward reaction in matched group 5, wherein 2 infants occurred
Quick reaction, shows as shiver with cold, hyperpyrexia, gives remission after dexamethasone static push, and 3 show as erythra, give chlorphenamine mouth
Remission after clothes.
Claims (3)
1. a kind of preparation method of autumn pear lung-nourishing semifluid extract, wherein,
The autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Bulbus Lilii, Flos Farfarae, crystal sugar, old processed with honey into；Its preparation method includes
Following steps：Take 400-800g autumn pears to clean, put in juice extractor and blend, collect Sucus Pyri, the pears slag 4 times of decoctings measured that add water boil 1.5
Hour, filtration, filtrate merges with Sucus Pyri, is evaporated to relative density for 1.45（50℃）Fructus Pyri thin paste；Take Bulbus Fritillariae Cirrhosae 50-
160g is ground into coarse powder, uses 58% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；40-100g draw downs Radix Ophiopogonis are taken, is used
30% ethanol percolation, collects 6 times of percolates, decompression recycling ethanol；Take Bulbus Lilii 20-60g, Flos Farfarae 20-60g to add water to cook three times,
The water yield is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, filtration, filtrate and Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis
Percolate merges, and is evaporated to relative density for 1.45（50℃）Clear paste, with crystal sugar after merging with above-mentioned Fructus Pyri thin paste
Mixing clear paste is made in 200g heating mixings；Add old honey 100g per 100g mixing clear paste, mix, obtain final product.
2. preparation method as claimed in claim 1, it is characterised in that the autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, hundred
Conjunction, Flos Farfarae, crystal sugar, old processed with honey into；Its preparation method comprises the steps：Take 700-800g autumn pears to clean, in putting juice extractor
Blend, collect Sucus Pyri, the pears slag 4 times of decoctings measured that add water are boiled 1.5 hours, are filtered, and filtrate merges with Sucus Pyri, are evaporated to relatively
Density is 1.45（50℃）Fructus Pyri thin paste；Take Bulbus Fritillariae Cirrhosae 80-140g and be ground into coarse powder, use 58% ethanol percolation, collect 6 times of percolation
Liquid, decompression recycling ethanol；70-90g draw downs Radix Ophiopogonis are taken, 30% ethanol percolation is used, 6 times of percolates, decompression recycling ethanol is collected；Take
Bulbus Lilii 55-60g, Flos Farfarae 40-55g are added water to cook three times, and the water yield is respectively 8 times, 6 times, 6 times, and it is little that decocting time is respectively 3
When, 2 hours, 1 hour, filtration, filtrate merges with Bulbus Fritillariae Cirrhosae, percolate Radix Ophiopogonis, and it is 1.45 to be evaporated to relative density（50
℃）Clear paste, after merging with above-mentioned Fructus Pyri thin paste with crystal sugar 200g heating mixing make mixing clear paste；Add always per 100g mixing clear paste
Sweet 100g, mixes, and obtains final product.
3. preparation method as claimed in claim 1, it is characterised in that the autumn pear lung-nourishing semifluid extract by autumn pear, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, hundred
Conjunction, Flos Farfarae, crystal sugar, old processed with honey into；Its preparation method comprises the steps：Take 750g autumn pears to clean, put in juice extractor and blend,
Sucus Pyri is collected, the pears slag 4 times of decoctings measured that add water are boiled 1.5 hours, are filtered, and filtrate merges with Sucus Pyri, is evaporated to relative density
For 1.45（50℃）Fructus Pyri thin paste；Take Bulbus Fritillariae Cirrhosae 130g and be ground into coarse powder, use 58% ethanol percolation, collect 6 times of percolates, decompression
Reclaim ethanol；85g draw downs Radix Ophiopogonis are taken, 30% ethanol percolation is used, 6 times of percolates, decompression recycling ethanol is collected；Take Bulbus Lilii 55g, money
Flos Farfarae 50g is added water to cook three times, and the water yield is respectively 8 times, 6 times, 6 times, and decocting time is respectively 3 hours, 2 hours, 1 hour, filter
Cross, filtrate merges with Bulbus Fritillariae Cirrhosae, percolate Radix Ophiopogonis, and be evaporated to relative density for 1.45（50℃）Clear paste, it is and above-mentioned
Fructus Pyri thin paste makes mixing clear paste after merging with crystal sugar 200g heating mixings；Add old honey 100g per 100g mixing clear paste, mix, i.e.,
.
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| CN111558002A (en) * | 2019-05-28 | 2020-08-21 | 葵花药业集团湖北武当有限公司 | Preparation method of autumn pear lung moistening paste |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095645A (en) * | 2006-06-27 | 2008-01-02 | 王博 | Method for making pear syrup |
| CN102266479A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Fritillary and snow pear particle and preparation method thereof |
| CN102266480A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Bulbus fritilariae snow pear capsules and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095645A (en) * | 2006-06-27 | 2008-01-02 | 王博 | Method for making pear syrup |
| CN102266479A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Fritillary and snow pear particle and preparation method thereof |
| CN102266480A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Bulbus fritilariae snow pear capsules and preparation method thereof |
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