CN107998240A - A kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind and preparation method thereof - Google Patents
A kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind and preparation method thereof Download PDFInfo
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- CN107998240A CN107998240A CN201711222076.9A CN201711222076A CN107998240A CN 107998240 A CN107998240 A CN 107998240A CN 201711222076 A CN201711222076 A CN 201711222076A CN 107998240 A CN107998240 A CN 107998240A
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Abstract
The invention discloses a kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind, the formula of the health care buccal tablets is formulated by the raw material of following parts by weight：1~4 part of 6~12 parts of 15~25 parts of honeysuckle, 9~18 parts of dandelion, 16~22 parts of lemon, 4~9 parts of Siraitia grosvenorii, 18~25 parts of coffee, 30~38 parts of green tea, 20~40 parts of betel nut, 4~10 parts of radix glycyrrhizae, 6~12 parts of oligofructose and maltodextrin, 1~3 part of magnesium stearate, 1~3 part of talcum powder and soluble starch, and disclose its preparation method, each raw material is carried out to decoction extraction successively, lotion is condensed into, dry cream fine powder, particle and tablet is made, obtains the health care buccal tablets.The lozenge of the fatigue-relieving clearing health care that refreshes the mind of the present invention can improve the immunity of the human body, allow people to feel mental excitation and eliminate the fatigue mitigation sore-throat after nervous work, and reduce throat discomfort.
Description
Technical field
The invention belongs to technical field of health care products, more particularly to one kind refreshes the mind fatigue-relieving clearing health care buccal tablets
Formula and preparation method thereof.
Background technology
Fatigue is a kind of natural phenomena, mainly includes physiologic fatigability and psychological fatigue, and physiological fatigue is mainly shown as
DOMS, general fatigue etc., can be by resting, sleeping and the measure such as nutrition is alleviated, and the main table of mental fatigue
It is now irritated, absent minded, thought slowness of mood etc..Due to working, learning tasks are heavy and the accelerating rhythm of life, warp
High intensity, the work of high pressure challenge are often faced, neurolysis, listless, brains occurs with brain and fatigue for a long time
The symptoms such as dusk is swollen, excited, dysphoria and heart are scorching, making people, pressure increases at heart, thus causes physiology of knowing clearly tired
Labor is more and more prominent, and throat discomfort makes one to concentrate one's energy or somatosensory is uncomfortable, influences routine work learning life therefore
People are badly in need of a kind of convenient, quality-high and inexpensive, the fatigue-relieving clearing that can refresh the mind food or health treatment.
The content of the invention
It is an object of the invention to：For above-mentioned problem, there is provided one kind refreshes the mind fatigue-relieving clearing health care
Formula of lozenge and preparation method thereof, the lozenge of the fatigue-relieving clearing health care that refreshes the mind of the invention can improve human immunity
Power, allow people to feel mental excitation and eliminate the fatigue mitigation sore-throat after nervous work, and reduces throat discomfort.On realizing
Goal of the invention is stated, the technical solution adopted by the present invention is as follows：
According to an aspect of the present invention, there is provided a kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind, the guarantor
The formula of strong lozenge is formulated by the raw material of following parts by weight：15~25 parts of honeysuckle, 9~18 parts of dandelion, lemon 16~
22 parts, 4~9 parts of Siraitia grosvenorii, 18~25 parts of coffee, 30~38 parts of green tea, 20~40 parts of betel nut, 4~10 parts of radix glycyrrhizae, oligofructose
6~12 parts and 1~4 part of 6~12 parts of maltodextrin, 1~3 part of magnesium stearate, 1~3 part of talcum powder and soluble starch.
Preferably, the formula of the health care buccal tablets is formulated by the raw material of following parts by weight：20 parts of honeysuckle, dandelion
15 parts, 18 parts of lemon, 7 parts of Siraitia grosvenorii, 22 parts of coffee, 36 parts of green tea, 32 parts of betel nut, 8 parts of radix glycyrrhizae, 9 parts of oligofructose and malt
10 parts of dextrin, 2 parts of magnesium stearate, 2 parts of talcum powder, 3 parts of soluble starch.
Preferably, the solubility of the soluble starch is 80%~85%, and moisture content is less than 5%, apparent viscosity 20-
23cp。
Preferably, the soluble starch is one kind in tapioca, cornstarch, potato starch or small rice starch.
According to another aspect of the present invention, there is provided a kind of health products for the fatigue-relieving clearing health care buccal tablets that refresh the mind
Preparation method, includes the following steps：
Step 1：Respectively raw material is taken by following parts by weight：Honeysuckle, dandelion, lemon, Siraitia grosvenorii, coffee, green tea, Bin
Bulky, radix glycyrrhizae, oligofructose part and maltodextrin, magnesium stearate, talcum powder and soluble starch；Step 2：Respectively by lemon, sieve
Chinese fruit and betel nut cut into slices, dry, are broken into fine powder, are extracted with ethanol, and extracting solution is through filtering, being concentrated to give lotion A, thickening temperature
Less than 70 DEG C of control, it is spare；
Step 3：Respectively by honeysuckle, dandelion, green tea and radix glycyrrhizae through water boiling and extraction, extracting solution is decocted through filtration, dense
Contracting proportion obtains concentration lotion B, less than 70 DEG C of thickening temperature control is spare to 1.20g/ml~1.30g/ml；
Step 4：Prepared by step 2 and step 3 the obtained lotion A and lotion B to be placed in material-compound tank, then adds coffee
Coffee is mixed and stirred evenly, and dry in less than 70 DEG C, obtains dry extract, dry extract crushed 70~90 mesh sieves, it is thin to obtain dry cream
Powder, it is spare,
Step 5, by dry cream fine powder and oligofructose that step 4 is prepared, maltodextrin be put into trough type mixing machine in the lump
Mixing 10~20 minutes, wet granular is made with 12~20 mesh nylon screens, so that the viscosity and lubricity of wet granular are effectively improved,
It can aid in and adapt to diabetic's use；
Step 6：The wet granular that step 5 is prepared, which is inserted in boiling drier, to be dried 20~30 minutes, is done
Discharging, particle is put into particle trough after dry, is carried out whole grain for 12~20 mesh nylon screens with sieve, is then transferred to two maintenance and operations again
Dynamic mixer is interior and adds magnesium stearate, talcum powder is mixed, and mixing adds soluble starch progress after 25~35 minutes
It is uniformly mixed, health care particle is made；So that health care particle again film-making when more lubricate, be not easy sliver, it is not easy to stick glutinous；
Step 7：Health care particle prepared by step 6 is added soluble starch to be mixed, stirs evenly, piece is then made
Agent, obtains the health products of the health care buccal tablets.
Preferably, the step 2 with ethanol extraction be use lemon, Siraitia grosvenorii, betel nut gross weight for 10 times~15 times,
The ethanol that concentration is 60%~80% dissolves, and carries out reflux and decocts extraction more than twice, and when extraction 1 is small every time, extracting solution passes through
Be separated by filtration add after filtrate and filter residue filter residue gross weight be 6 times~10 times, the ethanol that concentration is 85%, refluxing extraction
0.5 it is small when~1.5 it is small when, be then combined with extracting solution.
Such scheme is put into and carried it is further preferred that it is to shred honeysuckle that honeysuckle in the step 3, which decocts extraction,
Take tank add the water of 7~12 times of amounts decoct extraction 1.5 it is small when, be then separated by filtration filtrate and consider slag, in filter residue plus 6~10
The water of times amount, decoct extraction 1 it is small when, remerge filtrate twice after being separated by filtration, then temperature be 18 DEG C~22 DEG C, pressure be
Thickening filtration is carried out under the conditions of 2.5~2.8MPa, obtains honeysuckle lotion；
It is to shred dandelion that dandelion in the step 3, which decocts extraction, with 2 times of 60 DEG C~70 DEG C hot-water soaks 2
Extractor is put into after hour, then adds the water of 7~12 times of amounts, when then decoction extraction 1.5 is small, is then separated by filtration filtrate and worry
Slag, then add 6~10 times of water measured again in filter residue, when decoction extraction 1 is small, filtrate twice is remerged after being separated by filtration, then in temperature
Spend for 25 DEG C~28 DEG C, pressure be 2.8~3.0MPa thickening filtrations, obtain dandelion lotion；
It is to shred green tea that green tea in the step 3, which decocts extraction, is put into extractor, adds the water of 7~12 times of amounts to carry out
When decoction extraction 1.5 is small, then it is separated by filtration filtrate and considers slag, then add 6~10 times of water measured in filter residue, it is small decocts extraction 1
When, filtrate twice is merged after being separated by filtration, then by filtrate through anion exchange chromatography Separation ＆ Purification, then is coagulated through agarose
Glue column chromatography, then the thickening filtration under the conditions of temperature is 20 DEG C~25 DEG C, pressure is 2.0~2.5MPa, obtain green tea cream
Body；
It is to shred radix glycyrrhizae that radix glycyrrhizae in the step 3, which decocts extraction, is put into extractor, adds the water of 7~12 times of amounts to carry out
When decoction extraction 2 is small, then it is separated by filtration filtrate and considers slag, then add 6~10 times of water measured again in filter residue, it is small decocts extraction 1
When, filtrate twice is merged after being separated by filtration, then the filtering that is concentrated under reduced pressure is carried out, obtain radix glycyrrhizae lotion；
Such scheme it is further preferred that it is described be concentrated under reduced pressure be vacuum for 0.075MPa~0.085MPa, temperature
Under the conditions of 60 DEG C~70 DEG C, it is concentrated under reduced pressure, obtains radix glycyrrhizae lotion.
Such scheme is separated it is further preferred that stating and being separated by filtration using macroporous absorbent resin, the macroporous absorbent resin
Using ADS-17 or ADS-F8 models.
Such scheme is stirred it is further preferred that the rotating speed of the two-dimensional motion mixer is no more than 30r/min
Time is 10~20 minutes.
In raw material used in the present invention：
Honeysuckle：Honeysuckle is known as clearing heat and detoxicating good medicine from ancient times.It is containing chlorogenic acid, glucoside, flavonoids, volatile oil
Constituents.Glycosides composition includes saponin, iridoid glycoside etc., such as using ivy glucoside member as the triterpenoid saponin of aglucon, with caryophyllin
For the triterpenoid saponin of glucoside member；Flavone compound has 5- hydroxyls -3 ', 4,7- trimethoxy flavones, cyanidenon -7-O-a-D- Portugals
Grape glucoside, cyanidenon -7-O-b-D- galactosides, Quercetin -3-O-b-D- glycosides, hyperin etc.；In volatile oil
Containing more than 30 kinds components, thus honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, such as body heat, hair
The cards such as rash, hair spot, heat toxin sore carbuncle, abscess of throat, equal significant effect.
Dandelion：Dandelion has the effect of clearing heat and detoxicating, dispersing swelling and dissipating binds.Cure mainly the infection of the upper respiratory tract, eye conjunctivitis, stream
Row parotitis, hyperglycaemia, acute mastitis swelling and pain, gastritis, dysentery, hepatitis, chrysanthemum inflammation, acute appendicitis, urinary infection, pelvic cavity
Inflammation, carbuncle boils boils, pharyngitis control acute mastitis, adenolymphitis, scrofula, boil poisonous soreness, acute conjunctivitis, and cold, fever is acute
Tonsillitis, acute bronchitis, urinary tract infections.Dandelion Injectable Solution in vitro to staphylococcus aureus resistance bacterial strain,
Hemolytic streptococcus has stronger bactericidal effect, to Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, deformed rod
Bacterium, shigella dysenteriae, typhoid bacillus etc. and dandelion micrococcus catarrhalis also have certain bactericidal effect.Dandelion decoction can be shown in vitro
Write and improve human peripheral lymphocyte blast transformation rate.
Siraitia grosvenorii, sweet in flavor, sour, cool in nature, nutritive value is high, has clearing away summerheat, preventing phlegm from forming and stopping coughing, cool blood to relax bone, clearing lung-heat profit
Intestines and promote the production of body fluid to quench thirst and other effects；Available for prolonging life, preserve youthful looks Yue Se and treatment phlegm-heat cough, abscess of throat, constipation, disappear
Thirsty irritated all diseases, it can also be used to treating acute and chronic tracheitis, sphagitis, bronchial asthma, pertussis, stomach energy, constipation, acute almond
The diseases such as body inflammation.
Lemon：Lemon is all highly beneficial to human body rich in vitamin C, citric acid, malic acid, sodium element, potassium element etc.
Element；Because rich in beneficial to angiectatic flavonoid antioxidants, loosen body so lemon can reach, expand blood
The effect manage, to reduce blood pressure；The effect that calcium ion promotes blood clotting can be alleviated with prevention and cure of cardiovascular disease by eating lemon,
Hypertension and myocardial infarction can be prevented and treated, citric acid has contraction, reinforcement capillary, reduces permeability, improves blood coagulation work(
The effect of energy and platelet counts, can shorten clotting time and bleeding time 31%-71%, have anastalsis.
Radix glycyrrhizae, is glycyrrhizic legume (scientific name：Glycyrrhiza uralensis Fisch), alias：State is old, Herba Hedyotis cantonensis,
Glycyrrhiza Uralensis, sweet tea root.Nature and flavor are sweet, flat, gas is micro-, there is cough-relieving, relieving asthma, resolving sputum and adrenocortical hormones fuction, be resistant to
Inflammation, anti-aging, coordinating the drug actions of a prescription, anti-allergic effects, can protect the throat and tunica mucosa tracheae of inflammation, have and adjust immunity, disease-resistant
Poison and other effects.
Coffee, having stimulates central nervous system, heart and respiratory system.Muscular fatigue can also be mitigated, promote digestive juice
Secretion；Contain kahweol, caffeol and chlorogenic acid in coffee, there is anticancer and anti-inflammatory, and can promote
Glucose metabolism and raising insulin sensitivity.
Green tea, alias：Bitter tender tea leaves, natural tea polyphenols, catechin, chlorophyll, caffeine, amino acid, dimension are contained in green tea
The nutritional ingredients such as raw element.These nutritions have special-effect to anti-aging, anti-cancer, anticancer, sterilization, anti-inflammatory etc., have and wake up
Brain is refreshed oneself, and diuresis is recovered from fatigue, fatigue-relieving, the anti-ageing effect of waiting for a long time.
Betel nut (scientific name：Areca catechu L.) Palmae Areca aiphyllium, betel nut is warm-natured, cures mainly malnutrition due to parasitic infestation, food
The diseases such as stagnant, gastral cavity abdomen educated, oedema tinea pedis, have resisting cold, dispelling fatigue and other effects；Betel nut contains the nutrition member of a variety of needed by human body
Element and benefit materials, the main component of raw areca nut are 31.1% phenols, betel nut 0.3%-0.6% containing total alkaloid, mainly
Based on arecaline, and containing a small amount of arecaidine, guvacoline, different demethyl arecaidine, arecolidine and high Bin
Bulky alkali etc., also plays good antioxidation containing a small amount of aliphatic acid.
In conclusion above-mentioned technical proposal is employed, the beneficial effects of the invention are as follows：
(1), the health products of the fatigue-relieving clearing health care buccal tablets that refresh the mind of the invention containing honeysuckle, dandelion, lemon,
Siraitia grosvenorii, coffee, green tea, betel nut, the extract of radix glycyrrhizae, used material combination is reasonable, has stronger biological effect,
Safe without toxic side effect, have stimulate nervous centralis, it is clear-headed refresh oneself, fatigue-relieving, pharynx-clearing throat-benefiting, can also improve throat do it is bright,
Alleviate the effect of throat discomfort, Honegsukle flower P.E can dispelling wind-heat and removing summer-heat blood poison；Dandelion has clearing heat and detoxicating, detumescence
The effect of dissipating bind, bactericidal antiphlogistic；Radix glycyrrhizae energy anti-inflammatory, anti-aging, coordinating the drug actions of a prescription, anti-allergic effects, refreshing restoring consciouness fatigue-relieving clearing
Health care buccal tablets can effectively protect the throat and tunica mucosa tracheae of inflammation, have and adjust immunity, antiviral and other effects.The present invention's contains
Oligofructose is also used in piece and maltodextrin improves the viscosity of lozenge and is more suitable for various people and uses and also make
Lozenge is set more to lubricate by the use of magnesium stearate, talcum powder and soluble starch as auxiliary agent.
(2), the health products of health care buccal tablets of the invention effectively can keep raw material to have in preparation process to being separated by filtration
Component is imitated, fine powder, particle is made after the lotion that thickening filtration is formed again and is not easy sliver during extruding in flakes, passes through above-mentioned coffee
Coffee, green tea, betel nut can effectively improve the taste of health products, and the color and luster and mouth of health products can be effectively kept in storing process
Taste never degenerates, and while Chinese medicine original local flavor and effect is ensured, can effectively extend the time of lozenge storage, so as to persistently send out
The effect of waving drug effect, substantially increasing health products.
Embodiment
For the objects, technical solutions and advantages of the present invention are more clearly understood, preferred embodiment is enumerated below, to this hair
Bright further description.However, it is necessary to illustrate, many details listed in specification are used for the purpose of making reader to this
The one or more aspects of invention have a thorough explanation, can also realize the present invention's even without these specific details
These aspects.
Embodiment 1
This embodiment offers a kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind, the health care buccal tablets are matched somebody with somebody
Side is formulated by the raw material of following parts by weight：25 parts of honeysuckle, 9 parts of dandelion, 16 parts of lemon, 4 parts of Siraitia grosvenorii, coffee 18
6 parts of part, 30 parts of green tea, 20 parts of betel nut, 4 parts of radix glycyrrhizae, 6 parts of oligofructose and maltodextrin, 1 part of magnesium stearate, 1 part of talcum powder and
1 part of soluble starch, the solubility of the soluble starch is 80%, and moisture content is less than 5%, apparent viscosity 20cp.
The embodiment additionally provides a kind of preparation method for the fatigue-relieving clearing health care buccal tablets that refresh the mind, including following step
Suddenly：
Step 1：Respectively raw material is taken by following parts by weight：Honeysuckle, dandelion, lemon, Siraitia grosvenorii, coffee, green tea, Bin
Bulky, radix glycyrrhizae, oligofructose part and maltodextrin, magnesium stearate, talcum powder and soluble starch；
Step 2：Lemon, Siraitia grosvenorii and betel nut are cut into slices respectively, dry, are broken into fine powder, is extracted with ethanol, extracting solution warp
Filter, be concentrated to give lotion A, less than 70 DEG C of thickening temperature control is spare；In the present invention, with ethanol extraction be using lemon,
The ethanol dissolving that Siraitia grosvenorii, the gross weight of betel nut are 10 times, concentration is 80%, carries out reflux and decocts extraction more than twice, every time
Extract 1 it is small when, gross weight that extracting solution adds filter residue after being separated by filtration filtrate and filter residue is 6 times, concentration is 85%
Ethanol, when refluxing extraction 0.5 is small, is then combined with extracting solution；Described be separated by filtration is separated using macroporous absorbent resin, the macropore
Absorption resin uses ADS-17 or ADS-F8 models；
Step 3：Respectively by honeysuckle, dandelion, green tea and radix glycyrrhizae through water boiling and extraction, extracting solution is decocted through filtration, dense
Contracting proportion obtains concentration lotion B, less than 70 DEG C of thickening temperature control is spare to 1.20g/ml；
In the present invention, it is to shred honeysuckle that the honeysuckle, which decocts extraction, is put into extractor and adds the water of 7 times of amounts to carry out
Decoct extraction 1.5 it is small when, be then separated by filtration filtrate and consider slag, in filter residue plus 6 times amount water, decoct extraction 1 it is small when, filtering
Filtrate twice is remerged after separation, then thickening filtration is carried out under the conditions of temperature is 18 DEG C, pressure is 2.5MPa, obtains honeysuckle
Lotion；
It is to shred dandelion that the dandelion, which decocts extraction, with 60 DEG C of hot-water soaks 2 of 2 times of amounts it is small when after be put into extraction
Tank, then add 7 times of water measured, when then decoction extraction 1.5 is small, then it is separated by filtration filtrate and considers slag, then add 6 times again in filter residue
The water of amount, decoct extraction 1 it is small when, remerge filtrate twice after being separated by filtration, then temperature be 25 DEG C, pressure be 2.8MPa concentrations
Filtering, obtains dandelion lotion；
It is to shred green tea that the green tea, which decocts extraction, is put into extractor, adds 7 times of water measured to carry out decoction extraction 1.5 small
When, then it is separated by filtration filtrate and considers slag, then add the water of 6 times of amounts in filter residue, when decoction extraction 1 is small, merge after being separated by filtration
Filtrate twice, then by filtrate through anion exchange chromatography Separation ＆ Purification, then through agarose gel chromatography column purification, then
Thickening filtration under the conditions of temperature is 20 DEG C, pressure is 2.0MPa, obtains green tea lotion；
It is to shred radix glycyrrhizae that the radix glycyrrhizae, which decocts extraction, is put into extractor, add the water of 7 times of amounts decoct extraction 2 it is small when,
Then it is separated by filtration filtrate and considers slag, then add the water of 6 times of amounts again in filter residue, when decoction extraction 1 is small, merges two after being separated by filtration
Secondary filtrate, then the filtering that is concentrated under reduced pressure is carried out, obtain radix glycyrrhizae lotion；It is described be concentrated under reduced pressure be vacuum for 0.075MPaMPa, temperature
Spend under the conditions of 60 DEG C, to be concentrated under reduced pressure；Described be separated by filtration is separated using macroporous absorbent resin, the macroporous absorbent resin
Using ADS-17 or ADS-F8 models；
Step 4：Prepared by step 2 and step 3 the obtained lotion A and lotion B to be placed in material-compound tank, then adds coffee
Coffee is mixed and stirred evenly, and dry in less than 70 DEG C, obtains dry extract, dry extract crushed 70 mesh sieves, obtain dry cream fine powder, standby
With；
Step 5：The dry cream fine powder that step 4 is prepared is put into trough type mixing machine in the lump with oligofructose, maltodextrin
Mixing 10 minutes, wet granular is made with 12 mesh nylon screens；
Step 6：The wet granular that step 5 is prepared, which is inserted in boiling drier, to be dried 20 minutes, after dry
Discharging, particle is put into particle trough, whole grain is carried out with 12 mesh nylon screens, is then transferred to again in two-dimensional motion mixer simultaneously
Addition magnesium stearate, talcum powder are mixed, and the rotating speed of the two-dimensional motion mixer is no more than 30r/min, mixes 25 minutes
After add soluble starch and be stirred uniformly mixed 10 minutes, health care particle is made；
Step 7：Health care particle prepared by step 6 is added soluble starch to be mixed, stirs evenly, piece is then made
Agent, obtains the health products of the health care buccal tablets.
Embodiment 2
This embodiment offers a kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind, the health care buccal tablets are matched somebody with somebody
Side is formulated by the raw material of following parts by weight：15 parts of honeysuckle, 18 parts of dandelion, 22 parts of lemon, 9 parts of Siraitia grosvenorii, coffee 25
Part, 38 parts of green tea, 40 parts of betel nut, 10 parts of radix glycyrrhizae, 12 parts of oligofructose and 12 parts of maltodextrin, 3 parts of magnesium stearate, talcum powder 3
4 parts of part and soluble starch；The solubility of the soluble starch is 85%, moisture content 4.8%, apparent viscosity 23cp.
The embodiment additionally provides a kind of preparation method for the fatigue-relieving clearing health care buccal tablets that refresh the mind, including following step
Suddenly：
Step 1：Respectively raw material is taken by following parts by weight：Honeysuckle, dandelion, lemon, Siraitia grosvenorii, coffee, green tea, Bin
Bulky, radix glycyrrhizae, oligofructose part and maltodextrin, magnesium stearate, talcum powder and soluble starch；
Step 2：Lemon, Siraitia grosvenorii and betel nut are cut into slices respectively, dry, are broken into fine powder, is extracted with ethanol, extracting solution warp
Filter, be concentrated to give lotion A, less than 70 DEG C of thickening temperature control is spare；In the present invention, with ethanol extraction be using lemon,
The ethanol dissolving that Siraitia grosvenorii, the gross weight of betel nut are 15 times, concentration is 60%, carries out reflux and decocts extraction more than twice, every time
Extract 1 it is small when, gross weight that extracting solution adds filter residue after being separated by filtration filtrate and filter residue is 10 times, concentration is 85%
Ethanol, when refluxing extraction 1.5 is small, is then combined with extracting solution；Described be separated by filtration is separated using macroporous absorbent resin, the macropore
Absorption resin uses ADS-17 or ADS-F8 models；
Step 3：Respectively by honeysuckle, dandelion, green tea and radix glycyrrhizae through water boiling and extraction, extracting solution is decocted through filtration, dense
Contracting proportion obtains concentration lotion B, less than 70 DEG C of thickening temperature control is spare to 1.30g/ml；
In the present invention, it is to shred honeysuckle that the honeysuckle, which decocts extraction, be put into extractor add the water of 12 times of amounts into
Row decoct extraction 1.5 it is small when, be then separated by filtration filtrate and consider slag, in filter residue plus 10 times amount water, decoct extraction 1 it is small when,
Filtrate twice is remerged after being separated by filtration, then thickening filtration is carried out under the conditions of temperature is 22 DEG C, pressure is 2.8MPa, obtains gold
Honeysuckle flower lotion；
It is to shred dandelion that the dandelion, which decocts extraction, with 70 DEG C of hot-water soaks 2 of 2 times of amounts it is small when after be put into extraction
Tank, then add 12 times of water measured, when then decoction extraction 1.5 is small, then it is separated by filtration filtrate and considers slag, then add 10 again in filter residue
The water of times amount, decoct extraction 1 it is small when, remerge filtrate twice after being separated by filtration, then temperature be 28 DEG C, pressure be 3.0MPa dense
Contracting filtering, obtains dandelion lotion；
It is to shred green tea that the green tea, which decocts extraction, is put into extractor, adds 12 times of water measured to carry out decoction extraction 1.5 small
When, then it is separated by filtration filtrate and considers slag, then add the water of 10 times of amounts in filter residue, when decoction extraction 1 is small, merge after being separated by filtration
Filtrate twice, then by filtrate through anion exchange chromatography Separation ＆ Purification, then through agarose gel chromatography column purification, then
Thickening filtration under the conditions of temperature is 25 DEG C, pressure is 2.5MPa, obtains green tea lotion；
It is to shred radix glycyrrhizae that the radix glycyrrhizae, which decocts extraction, is put into extractor, adds 12 times of water measured to carry out decoction extraction 2 small
When, then it is separated by filtration filtrate and considers slag, then add the water of 10 times of amounts again in filter residue, when decoction extraction 1 is small, closed after being separated by filtration
And filtrate, then carry out the filtering that is concentrated under reduced pressure twice, obtain radix glycyrrhizae lotion；It is described be concentrated under reduced pressure be vacuum for 0.085MPa,
Under the conditions of temperature is 70 DEG C, it is concentrated under reduced pressure；Described be separated by filtration is separated using macroporous absorbent resin, the macroporous absorption tree
Fat uses ADS-17 or ADS-F8 models；
Step 4：Prepared by step 2 and step 3 the obtained lotion A and lotion B to be placed in material-compound tank, then adds coffee
Coffee is mixed and stirred evenly, and dry in less than 70 DEG C, obtains dry extract, dry extract crushed 90 mesh sieves, obtain dry cream fine powder, standby
With；
Step 5：The dry cream fine powder that step 4 is prepared is put into trough type mixing machine in the lump with oligofructose, maltodextrin
Mixing 20 minutes, wet granular is made with 20 mesh nylon screens；
Step 6：The wet granular that step 5 is prepared, which is inserted in boiling drier, to be dried 20~30 minutes, is done
Discharging, particle is put into particle trough after dry, is carried out whole grain for 20 mesh nylon screens with sieve, is then transferred to two dimensional motion again and mixes
Conjunction machine is interior and adds magnesium stearate, talcum powder is mixed, and the rotating speed of the two-dimensional motion mixer is no more than 30r/min, mixes
Soluble starch is added after closing 35 minutes to be stirred uniformly mixed 20 minutes, and health care particle is made；
Step 7：Health care particle prepared by step 6 is added soluble starch to be mixed, stirs evenly, piece is then made
Agent, obtains the health products of the health care buccal tablets.
Embodiment 3
This embodiment offers a kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind, the health care buccal tablets are matched somebody with somebody
Side is formulated by the raw material of following parts by weight：20 parts of honeysuckle, 15 parts of dandelion, 18 parts of lemon, 7 parts of Siraitia grosvenorii, coffee 22
10 parts of part, 36 parts of green tea, 32 parts of betel nut, 8 parts of radix glycyrrhizae, 9 parts of oligofructose and maltodextrin, 2 parts of magnesium stearate, 2 parts of talcum powder,
3 parts of soluble starch；The solubility of the soluble starch is 82%, and moisture content is less than 4.6%, apparent viscosity 21cp.
The embodiment additionally provides a kind of preparation method for the fatigue-relieving clearing health care buccal tablets that refresh the mind, including following step
Suddenly：
Step 1：Respectively raw material is taken by following parts by weight：Honeysuckle, dandelion, lemon, Siraitia grosvenorii, coffee, green tea, Bin
Bulky, radix glycyrrhizae, oligofructose part and maltodextrin, magnesium stearate, talcum powder and soluble starch；
Step 2：Lemon, Siraitia grosvenorii and betel nut are cut into slices respectively, dry, are broken into fine powder, is extracted with ethanol, extracting solution warp
Filter, be concentrated to give lotion A, less than 70 DEG C of thickening temperature control is spare；In the present invention, with ethanol extraction be using lemon,
The dissolving of Siraitia grosvenorii, the gross weight of betel nut are 13 times, concentration is 70%~75% ethanol, carry out reflux decoct extraction twice with
On, when extraction 1 is small every time, gross weight that extracting solution adds filter residue after being separated by filtration filtrate and filter residue is 8 times, concentration is
85% ethanol, when refluxing extraction 1.2 is small, is then combined with extracting solution；Described be separated by filtration is separated using macroporous absorbent resin, institute
State macroporous absorbent resin and use ADS-17 or ADS-F8 models；
Step 3：Respectively by honeysuckle, dandelion, green tea and radix glycyrrhizae through water boiling and extraction, extracting solution is decocted through filtration, dense
Contracting proportion obtains concentration lotion B, less than 70 DEG C of thickening temperature control is spare to 1.25g/ml；
In the present invention, it is to shred honeysuckle that the honeysuckle, which decocts extraction, be put into extractor add the water of 10 times of amounts into
When decoction extraction 1.5 of going is small, then it is separated by filtration filtrate and considers slag, 6~10 times of water measured is added in filter residue, it is small to decoct extraction 1
When, filtrate twice is remerged after being separated by filtration, then thickening filtration is carried out under the conditions of temperature is 20 DEG C, pressure is 2.7MPa, obtain
To honeysuckle lotion；
It is to shred dandelion that the dandelion, which decocts extraction, when small with 2 times two of 67 DEG C of hot-water soaks 2 after be put into extraction
Tank, then add 9 times of water measured, when then decoction extraction 1.5 is small, then it is separated by filtration filtrate and considers slag, then add 8 times again in filter residue
The water of amount, decoct extraction 1 it is small when, remerge filtrate twice after being separated by filtration, then temperature be 27 DEG C, pressure be 2.9MPa concentrations
Filtering, obtains dandelion lotion；
It is to shred green tea that the green tea, which decocts extraction, is put into extractor, adds 10 times of water measured to carry out decoction extraction 1.5 small
When, then it is separated by filtration filtrate and considers slag, then add the water of 6~10 times of amounts in filter residue, when decoction extraction 1 is small, after being separated by filtration
Merge filtrate twice, then by filtrate through anion exchange chromatography Separation ＆ Purification, then through agarose gel chromatography column purification,
The thickening filtration under the conditions of temperature is 22 DEG C, pressure is 2.1MPa again, obtains green tea lotion；
It is to shred radix glycyrrhizae that the radix glycyrrhizae, which decocts extraction, is put into extractor, add the water of 9 times of amounts decoct extraction 2 it is small when,
Then it is separated by filtration filtrate and considers slag, then add the water of 8 times of amounts again in filter residue, when decoction extraction 1 is small, merges two after being separated by filtration
Secondary filtrate, then the filtering that is concentrated under reduced pressure is carried out, obtain radix glycyrrhizae lotion；It is described be concentrated under reduced pressure be vacuum be 0.08MPa, temperature be
Under the conditions of 67 DEG C, it is concentrated under reduced pressure；Described be separated by filtration is separated using macroporous absorbent resin, and the macroporous absorbent resin uses
ADS-17 or ADS-F8 models；
Step 4：Prepared by step 2 and step 3 the obtained lotion A and lotion B to be placed in material-compound tank, then adds coffee
Coffee is mixed and stirred evenly, and dry in less than 70 DEG C, obtains dry extract, dry extract crushed 85 mesh sieves, obtain dry cream fine powder, standby
With；
Step 5：The dry cream fine powder that step 4 is prepared is put into trough type mixing machine in the lump with oligofructose, maltodextrin
Mixing 16 minutes, wet granular is made with 15 mesh nylon screens；
Step 6：The wet granular that step 5 is prepared, which is inserted in boiling drier, to be dried 25 minutes, after dry
Discharging, particle is put into particle trough, whole grain is carried out with 15 mesh nylon screens, is then transferred to again in two-dimensional motion mixer simultaneously
Addition magnesium stearate, talcum powder are mixed, and the rotating speed of the two-dimensional motion mixer is no more than 30r/min, mixes 30 minutes
After add soluble starch and be stirred uniformly mixed 16 minutes, health care particle is made；
Step 7：Health care particle prepared by step 6 is added soluble starch to be mixed, stirs evenly, piece is then made
Agent, obtains the health products of the health care buccal tablets.
Embodiment 4
First, safety testing
By the health products slice lapping of the health care buccal tablets of the present invention into after powder, it is dissolved in water, it is spare；Small white mouse 100 is taken,
Weight 18-22g, each 50 of male and female, are divided into four groups, and every group 25, one of which is normal amount test group, and in addition three groups are extraordinary
Measure test group.The medication of normal amount group is 2mg/10g, and excess group is 4mg/10g, and administering mode is administered for administration by gavage, daily morning and evening
Respectively once, one week is even served, observes medication reaction daily.The result shows that：Each group mouse behavior is without exception, no poisoning symptom, appetite,
Excrement is without exception, and general signs are good, shows that the health products of the health care buccal tablets of the present invention are safe and free of toxic and side effects.
2nd, clinical observation experiment
(1), pharynx-clearing throat-benefiting clinical test：The health products of the refreshing restoring consciouness fatigue-relieving clearing health care buccal tablets of the present invention contribute to
Stimulate nervous centralis, it is clear-headed refresh oneself, fatigue-relieving, pharynx-clearing throat-benefiting etc., the health care of health care buccal tablets of the present invention is put down for treating pharynx
Inflammation, acute, patients with chronic pharyngitis, patient suck lozenge, generally find that pharyngalgia, hoarse voice, expectoration be not well, throat after 2 days
The pharyngitis symptom such as portion's foreign body sensation is obviously improved.After taking 5 days for chronic pharyngitis, it is almost recovered.Specific efficacy assessment standard ginseng
It is shown in Table 1：
Table 1
In conclusion the health products of the lozenge of the present invention are verified by Long-term clinical, it treats the effect of acute/chronic pharyngitis
Clearly, it is evident in efficacy, it can obviously improve throat symptom, the high efficiency such as pharyngalgia, silent, expectoration is not well, bottleneck throat foreign body sensation and reach
More than 92%, wherein acpuei pharyngitis cure rate is up to more than 95%, and chronic pharyngitis cure rate is up to more than 92%, and without anti-
It is multiple, so as to effectively increase the immunity of user.
(2) fatigue-relieving is tested：Influence of the health products of the lozenge of the present invention to outdoor activities fatigue：
Choose 70 people of volunteer, 45 people of male, 25 people of women, the age, health, these volunteers were big at 20-60 Sui
Most usually operating pressures are big, and mood is irritated, the absent minded, symptom such as feel exhausted；Application method：Each taking
The health products of the lozenge of 200mg, took 1 time every 30 minutes, continuously take twice.Wherein, when 24 people mountain-climbing 2-3 is small, then
Take, when 24 people swimming 1 is small, then take, wherein 22 people play soccer 1.5 it is small when, then take, volunteer understood after 3 days
DOMS and general fatigue recovery situation, test result indicates that, total significant figure reaches 100%, and significant effect has 54, effect
Less 16, drawn from experimental result the health products of lozenge of the present invention be to the effect of fatigue to outdoor activities it is effective,
It can make loosening all muscles, fatigue is able to rapid recovery, allows people to feel mental excitation and eliminates the fatigue after nervous outdoor activities；Also
It is big to can aid in usually operating pressure, often feels fatigue, after irritated patient's use, 90% patient volunteer can pacify
God is with all worries set aside, and spirit takes an evident turn for the better, and feeling of fatigue is obviously reduced, therefore the health products of the lozenge of the present invention are with obviously clear
Wake up refresh oneself, pharynx-clearing throat-benefiting and fatigue-relieving effect, and edible safety has no toxic side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the principle of the present invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
- A kind of 1. formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind, it is characterised in that：The formula of the health care buccal tablets by The raw material of following parts by weight is formulated：15~25 parts of honeysuckle, 9~18 parts of dandelion, 16~22 parts of lemon, Siraitia grosvenorii 4~9 Part, 18~25 parts of coffee, 30~38 parts of green tea, 20~40 parts of betel nut, 4~10 parts of radix glycyrrhizae, 6~12 parts of oligofructose and malt paste 1~4 part of 6~12 parts of essence, 1~3 part of magnesium stearate, 1~3 part of talcum powder and soluble starch.
- A kind of 2. formula of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 1, it is characterised in that：Institute The formula for stating health care buccal tablets is formulated by the raw material of following parts by weight：20 parts of honeysuckle, 15 parts of dandelion, 18 parts of lemon, sieve 7 parts of Chinese fruit, 22 parts of coffee, 36 parts of green tea, 32 parts of betel nut, 8 parts of radix glycyrrhizae, 9 parts of oligofructose and 10 parts of maltodextrin, magnesium stearate 2 parts, 2 parts of talcum powder, 3 parts of soluble starch.
- 3. a kind of formula of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 1 or 2, its feature exist In：The solubility of the soluble starch is 80%~85%, and moisture content is less than 5%, apparent viscosity 20-23cp.
- A kind of 4. formula of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 3, it is characterised in that：Institute Soluble starch is stated as one kind in tapioca, cornstarch, potato starch or small rice starch.
- A kind of 5. preparation method for the fatigue-relieving clearing health care buccal tablets that refresh the mind, it is characterised in that：Include the following steps：Step 1：Respectively raw material is taken by following parts by weight：It is honeysuckle, dandelion, lemon, Siraitia grosvenorii, coffee, green tea, betel nut, sweet Grass, oligofructose part and maltodextrin, magnesium stearate, talcum powder and soluble starch；Step 2：Lemon, Siraitia grosvenorii and betel nut are cut into slices respectively, dry, are broken into fine powder, is extracted with ethanol, extracting solution is through filter Cross, be concentrated to give lotion A, less than 70 DEG C of thickening temperature control is spare；Step 3：Honeysuckle, dandelion, green tea and radix glycyrrhizae are decocted into extracting solution through filtration, cocnentration factor through water boiling and extraction respectively Weight obtains concentration lotion B, less than 70 DEG C of thickening temperature control is spare to 1.20g/ml~1.30g/ml；Step 4, prepare the obtained lotion A and lotion B by step 2 and step 3 and be placed in material-compound tank, then adds coffee and mixes It is even to stir evenly and dry in less than 70 DEG C, obtain dry extract, dry extract crushed the mesh sieve of 70 mesh sieves~90, and it is thin to obtain dry cream Powder, it is spare,Step 5, by dry cream fine powder and oligofructose that step 4 is prepared, maltodextrin be put into trough type mixing machine and mix in the lump 10 minutes~20 minutes, wet granular is made with the mesh nylon screen of 12 mesh~20；Step 6：The wet granular that step 5 is prepared, which is inserted in boiling drier, to be dried 20 minutes~30 minutes, is done Discharging, particle is put into particle trough after dry, is carried out whole grain with the mesh nylon screen of 12 mesh~20, is then transferred to two dimensional motion again In mixer and add magnesium stearate, talcum powder is mixed, mixing added after 25 minutes~35 minutes soluble starch into Row is uniformly mixed, and health care particle is made；Step 7：Health care particle prepared by step 6 is added soluble starch to be mixed, stirs evenly, tablet is then made, Obtain the health products of the health care buccal tablets.
- 6. a kind of preparation method of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 5, its feature exist In：The step 2 with ethanol extraction be use lemon, Siraitia grosvenorii, betel nut gross weight for 10 times~15 times, concentration be 60%~ 80% ethanol dissolving, carries out reflux and decocts extraction more than twice, when extraction 1 is small every time, extracting solution is separated by filtration filtrate With added after filter residue filter residue gross weight be 6 times~10 times, the ethanol that concentration is 85%, when refluxing extraction 0.5 is small~1.5 small When, it is then combined with extracting solution.
- 7. a kind of preparation method of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 5, its feature exist In：It is to shred honeysuckle that honeysuckle in the step 3, which decocts extraction, is put into extractor and adds the water of 7~12 times of amounts to be decocted Boil extraction 1.5 it is small when, be then separated by filtration filtrate and consider slag, in filter residue plus 6~10 times amount water, decoct extraction 1 it is small when, mistake Filtrate twice is remerged after filter separation, then is carried out under the conditions of temperature is 18 DEG C~22 DEG C, pressure is 2.5MPa~2.8MPa dense Contracting filtering, obtains honeysuckle lotion；It is to shred dandelion that dandelion in the step 3, which decocts extraction, when small with 2 times of 60 DEG C~70 DEG C hot-water soaks 2 After be put into extractor, then add the water of 7~12 times of amounts, then decoct extraction 1.5 it is small when, be then separated by filtration filtrate and consider slag, then In filter residue again plus 6~10 times of amounts water, decoct extraction 1 it is small when, remerge filtrate twice after being separated by filtration, then in temperature be 25 DEG C~28 DEG C, pressure be 2.8~3.0MPa thickening filtrations, obtain dandelion lotion；It is to shred green tea that green tea in the step 3, which decocts extraction, is put into extractor, adds the water of 7~12 times of amounts to be decocted Extract 1.5 it is small when, be then separated by filtration filtrate and consider slag, then in filter residue plus 6~10 times amount water, decoct extraction 1 it is small when, mistake Merge filtrate twice after filter separation, then by filtrate through anion exchange chromatography Separation ＆ Purification, then through Ago-Gel layer Column purification, then the thickening filtration under the conditions of temperature is 20 DEG C~25 DEG C, pressure is 2.0MPa~2.5MPa are analysed, obtains green tea cream Body；It is to shred radix glycyrrhizae that radix glycyrrhizae in the step 3, which decocts extraction, is put into extractor, adds the water of 7~12 times of amounts to be decocted Extract 2 it is small when, be then separated by filtration filtrate and consider slag, then in filter residue again plus 6~10 times amount water, decoct extraction 1 it is small when, mistake Merge filtrate twice after filter separation, then carry out the filtering that is concentrated under reduced pressure, obtain radix glycyrrhizae lotion.
- 8. a kind of preparation method of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 7, its feature exist In：Described be concentrated under reduced pressure is under the conditions of vacuum is 0.075MPa~0.085MPa, temperature is 60 DEG C~70 DEG C, is depressurized Concentration, obtains radix glycyrrhizae lotion.
- 9. a kind of preparation method of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 6 or 7, its feature It is：Described be separated by filtration is separated using macroporous absorbent resin, and the macroporous absorbent resin uses ADS-17 or ADS-F8 models.
- 10. a kind of preparation method of fatigue-relieving clearing health care buccal tablets that refresh the mind according to claim 5, its feature exist In：The rotating speed of the two-dimensional motion mixer is no more than 30r/min, and the time being stirred is 10 minutes~20 minutes.
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Application publication date: 20180508 |