CN110664906B - Preparation method of health food with blood sugar reducing function - Google Patents
Preparation method of health food with blood sugar reducing function Download PDFInfo
- Publication number
- CN110664906B CN110664906B CN201910901417.8A CN201910901417A CN110664906B CN 110664906 B CN110664906 B CN 110664906B CN 201910901417 A CN201910901417 A CN 201910901417A CN 110664906 B CN110664906 B CN 110664906B
- Authority
- CN
- China
- Prior art keywords
- parts
- ethanol
- health food
- mixing
- blood sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 67
- 239000008280 blood Substances 0.000 title claims abstract description 67
- 235000013402 health food Nutrition 0.000 title claims abstract description 54
- 230000001603 reducing effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 235000001498 Salvia hispanica Nutrition 0.000 claims abstract description 28
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 claims abstract description 27
- 235000014167 chia Nutrition 0.000 claims abstract description 27
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 24
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 23
- 241000222336 Ganoderma Species 0.000 claims abstract description 23
- 240000000249 Morus alba Species 0.000 claims abstract description 23
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 23
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 235000019225 fermented tea Nutrition 0.000 claims abstract description 19
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 15
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 15
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 15
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 15
- 241000131458 Elsholtzia Species 0.000 claims abstract description 11
- 241000208688 Eucommia Species 0.000 claims abstract description 7
- 244000061520 Angelica archangelica Species 0.000 claims abstract description 6
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 6
- 241000208966 Polygala Species 0.000 claims abstract description 5
- 235000013305 food Nutrition 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 130
- 238000002156 mixing Methods 0.000 claims description 46
- 239000000706 filtrate Substances 0.000 claims description 32
- 244000269722 Thea sinensis Species 0.000 claims description 27
- 238000001914 filtration Methods 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 235000006468 Thea sinensis Nutrition 0.000 claims description 18
- 235000020279 black tea Nutrition 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 14
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 241000723353 Chrysanthemum Species 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 241000717679 Mosla Species 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 244000292604 Salvia columbariae Species 0.000 claims 4
- 230000000694 effects Effects 0.000 abstract description 31
- 240000005481 Salvia hispanica Species 0.000 abstract description 24
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract description 19
- 230000003647 oxidation Effects 0.000 abstract description 5
- 238000007254 oxidation reaction Methods 0.000 abstract description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 4
- 206010020772 Hypertension Diseases 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 2
- 230000003796 beauty Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 18
- 210000004185 liver Anatomy 0.000 description 14
- 244000237330 gutta percha tree Species 0.000 description 12
- 241000382455 Angelica sinensis Species 0.000 description 11
- 241001080798 Polygala tenuifolia Species 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 210000003734 kidney Anatomy 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 244000241838 Lycium barbarum Species 0.000 description 9
- 235000015459 Lycium barbarum Nutrition 0.000 description 9
- 235000015468 Lycium chinense Nutrition 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 235000013399 edible fruits Nutrition 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 235000019197 fats Nutrition 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 235000013616 tea Nutrition 0.000 description 7
- 238000005303 weighing Methods 0.000 description 7
- 241000628997 Flos Species 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 5
- 230000032683 aging Effects 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000036772 blood pressure Effects 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 238000009423 ventilation Methods 0.000 description 5
- 240000008397 Ganoderma lucidum Species 0.000 description 4
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 4
- 229920002774 Maltodextrin Polymers 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 208000012886 Vertigo Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 201000001421 hyperglycemia Diseases 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 4
- 229940035034 maltodextrin Drugs 0.000 description 4
- 230000000291 postprandial effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 238000005728 strengthening Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 4
- 231100000889 vertigo Toxicity 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 230000010415 tropism Effects 0.000 description 3
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 235000004883 caffeic acid Nutrition 0.000 description 2
- 229940074360 caffeic acid Drugs 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000020235 chia seed Nutrition 0.000 description 2
- 229940074393 chlorogenic acid Drugs 0.000 description 2
- 235000001368 chlorogenic acid Nutrition 0.000 description 2
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 2
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 2
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 235000008777 kaempferol Nutrition 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920001342 Bakelite® Polymers 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000208686 Eucommiaceae Species 0.000 description 1
- 244000268590 Euryale ferox Species 0.000 description 1
- 235000006487 Euryale ferox Nutrition 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 description 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000004637 bakelite Substances 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 239000003538 oral antidiabetic agent Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229940067631 phospholipid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000014620 theaflavin Nutrition 0.000 description 1
- IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 description 1
- 229940026509 theaflavin Drugs 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a preparation method of a health food with a blood sugar reducing function, and belongs to the technical field of food processing. The raw materials of the health food comprise dark tea, angelica, eucommia, honeysuckle, lucid ganoderma, medlar, polygala, chia, elsholtzia, chrysanthemum, mulberry leaves and isomaltooligosaccharide. The health food carefully selects the raw materials and scientifically combines the formula, not only has the health-care effect of reducing blood sugar, but also has the health-care effects of maintaining beauty and keeping young, preventing hypertension and hyperlipidemia, resisting oxidation, delaying senility, improving immunity and the like.
Description
The application is a divisional application of an invention patent application of application date 2016.02.01, application number 2016100688082, invention name 'a health food with blood sugar reducing function'.
Technical Field
The invention relates to a health food with a blood sugar reducing function, and belongs to the technical field of food processing.
Background
With the rapid development of economy, the living standard of people is greatly improved, and the probability of the people suffering from hyperglycemia and hyperlipidemia is also rapidly increased. In the aspect of health food, the health food for reducing blood sugar and blood fat is more and more popular with people. Hyperlipemia, hypercholesterolemia, hypertension and hyperglycemia are all epidemic diseases at present, and the topic of reducing blood fat and blood pressure is hot. According to statistics, about 1.5 hundred million diabetics exist in the world, 80 percent of diabetics are non-insulin dependent diabetes mellitus, namely type II diabetes mellitus, and more than 4000 million diabetics exist in China. At present, the diabetes mellitus is mainly treated by two types of chemical drugs and traditional Chinese medicines, and although the existing chemical drugs are main application drugs, the traditional Chinese medicines have good repairing effect on pancreatic islets while reducing blood sugar, so that the traditional Chinese medicine has good prospect in the diabetes mellitus treatment. Because of the non-healing property of the whole life of diabetes, drug resistance, drug side effects and the like, the demand of people of the type has great demand on the hypoglycemic health food. Type II diabetes is also called non-insulin dependent diabetes mellitus, hyperglycemia is the main symptom, and the control of blood sugar can obviously improve the occurrence and development of complications. At present, the market demands a safe hypoglycemic health food which can be taken for a long time.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide a health food with the function of reducing blood sugar. The health food has the health care effects of reducing blood sugar, beautifying, preventing hypertension and hyperlipidemia, resisting oxidation, delaying aging, improving immunity and the like by carefully selecting raw materials and scientifically composing the formula.
The technical scheme for realizing the aim of the invention is as follows:
a health food with blood sugar lowering effect is prepared from black tea, radix Angelicae sinensis, Eucommiae cortex, flos Lonicerae, Ganoderma, fructus Lycii, cortex et radix Polygalae, chia, herba Moslae, flos Chrysanthemi, folium Mori, and isomaltooligosaccharide.
Preferably, the health food comprises, by weight, 10-200 parts of dark tea, 1-10 parts of angelica sinensis, 5-50 parts of eucommia ulmoides, 10-200 parts of honeysuckle, 5-50 parts of ganoderma lucidum, 10-150 parts of wolfberry fruits, 5-20 parts of polygala tenuifolia, 5-100 parts of chia, 5-50 parts of elsholtzia, 10-200 parts of chrysanthemum, 5-100 parts of mulberry leaves and 0.1-1 part of isomaltooligosaccharide.
Preferably, the health food comprises, by weight, 50-150 parts of dark green tea, 2-8 parts of angelica sinensis, 10-40 parts of eucommia ulmoides, 50-150 parts of honeysuckle, 10-40 parts of ganoderma lucidum, 50-120 parts of wolfberry fruits, 10-15 parts of polygala tenuifolia, 10-80 parts of chia, 10-40 parts of elsholtzia, 50-150 parts of chrysanthemum, 10-80 parts of mulberry leaves and 0.2-0.8 part of isomaltooligosaccharide.
Preferably, the health food comprises, by weight, 120 parts of dark tea, 3 parts of angelica sinensis, 15 parts of eucommia ulmoides, 70 parts of honeysuckle, 15 parts of ganoderma lucidum, 80 parts of wolfberry fruit, 12 parts of polygala tenuifolia, 50 parts of chia, 30 parts of elsholtzia, 85 parts of chrysanthemum, 60 parts of mulberry leaves and 0.6 part of isomaltooligosaccharide.
The weight parts may be μ g, mg, g, kg, etc. known in the art, or multiples thereof, such as 1/10, 1/100, 10, 100, etc.
The health food with the function of reducing blood sugar is prepared from black tea, angelica sinensis, eucommia ulmoides, honeysuckle, lucid ganoderma, medlar, polygala tenuifolia, chia, elsholtzia, chrysanthemum, mulberry leaves and isomaltooligosaccharide as active ingredient raw materials; preferably, the raw materials or the auxiliary materials of the health food also comprise a pharmaceutically or food acceptable carrier or a health food acceptable carrier.
Preferably, the health food is prepared into an oral preparation; the method comprises the following steps: capsules, granules, tablets, bagged tea, powders and the like; more preferably granules.
Further preferably, the raw materials or auxiliary materials of the health food also comprise microcrystalline cellulose and magnesium stearate.
The invention also provides a preparation method of the health food, which comprises the following steps: weighing the components according to the proportion, mixing uniformly, and preparing into the preparation according to a conventional preparation method.
Preferably, the preparation method of the health food comprises the following steps:
1) preparing materials; weighing the required raw materials (including dark tea, angelica, eucommia, honeysuckle, lucid ganoderma, medlar, polygala, chia, elsholtzia, chrysanthemum, mulberry leaf, isomaltooligosaccharide and the like) according to the proportion;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, adding 5-10 times of 50-90% ethanol, reflux extracting for 1-3 times (0.5-3.0 hr each time), filtering, mixing filtrates, concentrating the filtrate to fluid extract (relative density of 1.10-1.30, 30 deg.C), adding ethanol to make ethanol content reach 70% -75% to obtain solution I;
3) mixing black tea, honeysuckle, medlar, chrysanthemum and mulberry leaves, adding water with the weight of 5-15 times, decocting for 1-3 times, each time for 0.5-2 hours, merging decoction, filtering, concentrating filtrate into clear paste (the relative density is 1.10-1.30, 30 ℃), adding ethanol until the ethanol content reaches 70-75%, and obtaining solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract (with relative density of 1.10-1.30 at 30 deg.C); adding isomaltooligosaccharide and appropriate amount of adjuvants according to the formulation to make into appropriate dosage form. Preferably, appropriate amount of microcrystalline cellulose and magnesium stearate are added to prepare granules.
Specifically, the preparation method of the health food comprises the following steps:
1) preparing materials; weighing the required raw materials (including dark tea, angelica, eucommia, honeysuckle, lucid ganoderma, medlar, polygala, chia, elsholtzia, chrysanthemum, mulberry leaf, isomaltooligosaccharide and the like) according to the proportion;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, reflux-extracting with 70% -75% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for 1 time, extracting with 6 times of ethanol for 1 hr for 2 times, filtering, mixing filtrates, concentrating the filtrate to fluid extract (relative density of 1.10-1.30, 30 deg.C), adding ethanol to make ethanol content reach 70% -75%, to obtain solution I;
3) mixing black tea, honeysuckle, medlar, chrysanthemum and mulberry leaves, adding water, decocting for 2 times, adding 10 times of water by weight for 2 hours for the 1 st time, adding 8 times of ethanol by weight for extracting for 1 hour for the 2 nd time, mixing decoctions, filtering, concentrating the filtrate to obtain clear paste (the relative density is 1.10-1.30, 30 ℃), adding ethanol until the ethanol content reaches 70% -75%, and obtaining a solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract (with relative density of 1.10-1.30 at 30 deg.C); adding isomaltooligosaccharide and appropriate amount of adjuvants according to the formula to make into appropriate dosage form; preferably, appropriate amount of microcrystalline cellulose and magnesium stearate are added to prepare granules.
Unless otherwise specified, the ethanol concentration in the invention refers to volume concentration.
Experiments prove that the process for extracting the traditional Chinese medicine raw materials furthest retains the active ingredients of the traditional Chinese medicine raw materials, and the extracted active ingredients are most easily absorbed by human bodies, so that the absorption of the medicine is enhanced, and the problem that the drug effect is interfered by ineffective ingredients is solved.
Dark tea (dark tea) is named as one of six major tea types and belongs to post-fermented tea because the appearance of the finished tea is black. Caffeine, vitamins, amino acids, phospholipids and the like in the dark tea are beneficial to human digestion and regulate fat metabolism, and the stimulation effect of the caffeine can improve the secretion of gastric juice, so that the appetite is promoted, and the digestion is facilitated. Scientific tests prove that the dark tea has strong functions of removing grease, helping digestion and the like, and the dark tea is also the reason why the meat nationality particularly likes the dark tea. In addition, the dark tea can improve the microbial environment of the intestinal tract and has the function of smoothing intestines and stomach. The old dark tea is used for treating abdominal distension, dysentery and indigestion in folks of China. Meanwhile, catechin, theaflavin, theanine and tea polysaccharide in the dark tea, especially complex flavonoid with high content and the like have the function of clearing free radicals, so that the dark tea has the effects of resisting oxidation and delaying cell aging.
Angelica sinensis (Oliv.) Diels, a plant of Umbelliferae, has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. It is commonly used for blood deficiency and sallow complexion, vertigo and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Eucommia ulmoides Oliver, also known as Bakelite, is the dried bark of Eucommia ulmoides Oliver belonging to family Eucommiaceae. It is sweet in taste and warm in nature. Has effects in tonifying liver and kidney, strengthening muscle and bone, regulating Chong and ren meridians, and preventing miscarriage. Can be used for treating lumbago, leg pain, soreness, weakness, and asthenia due to kidney yang deficiency, and symptoms such as hypochondriac instability, and scrotum pruritus due to liver qi deficiency. It is listed as the superior in Shen nong Ben Cao Jing. The modern research on eucommia bark has the effects of clearing away in-vivo garbage, strengthening the metabolism of human cell substances, preventing the aging of musculoskeletal tissues, balancing the blood pressure of a human body, decomposing in-vivo cholesterol, reducing in-vivo fat, restoring the elasticity of blood vessels, inducing diuresis, clearing heat, resisting bacteria in a broad spectrum, exciting central nerves and improving the pharmacological action of white blood cells.
The honeysuckle flower is cold in nature and sweet in taste, enters lung, heart and stomach channels, has the effects of clearing heat and removing toxicity, resisting inflammation, tonifying deficiency and treating wind, and is mainly used for treating diseases such as distending pain, epidemic febrile disease, fever, toxic heat, carbuncle and ulcer, tumor and the like. It has therapeutic effects on dizziness, thirst, hyperhidrosis, vexation, enteritis, bacillary dysentery, measles, pneumonia, encephalitis B, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle, furuncle, erysipelas, parotitis, and suppurative tonsillitis. The honeysuckle can improve microcirculation, remove fat deposition peroxide and promote metabolism; eucommia bark is effective in invigorating qi and improving spleen function and metabolism.
Ganoderma has effects of invigorating qi, tranquilizing mind, relieving cough and asthma, and can be used for treating vertigo, insomnia, palpitation, short breath, neurasthenia, asthenia, cough and asthma, and prolonging life. The ganoderma lucidum has the function of promoting blood circulation, and can remarkably improve the blood retardation of some tiny blood vessels. Similarly, Ganoderma can also promote blood circulation of facial small blood vessels, make skin cells obtain sufficient nutrients and oxygen, and promote skin metabolism.
The medlar is sweet and neutral in nature, enters liver and kidney meridians, and has the effects of nourishing liver and kidney, nourishing liver and improving eyesight. Modern medical research proves that: the medlar has sixteen functions of immunoregulation, oxidation resistance, aging resistance, tumor resistance, fatigue resistance, blood fat reduction, blood sugar reduction, blood pressure reduction, kidney tonifying, liver protection, eyesight improvement, face nourishing, brain strengthening, toxin expelling, reproductive system protection, radiation damage resistance and the like. In addition, it has skin whitening effect, because wolfberry can improve the ability of skin to absorb oxygen.
Polygala tenuifolia Willd has the functions of soothing the nerves, promoting intelligence, eliminating phlegm and reducing swelling, and is bitter, pungent and warm in nature. Meridian tropism includes heart, kidney and lung meridians. Can be used for treating insomnia, dreaminess, amnesia, pavor, absentmindedness, expectoration, skin and external diseases, swelling and pain of breast caused by imbalance between heart-yang and kidney-yin.
Chia (Chia Seed), also known as Chia Seed, academia gordon euryale (Salvia Hispanica L.), mint plants, originally produced in southern mexico and in the north america, guatemala, etc. The chia is the seed of the plant, namely chia seed. Chia is the most abundant food rich in omega-3 fatty acids and contains natural antioxidants. In addition to common antioxidant elements (vitamin E, C and lecithin), chia seed contains more abundant natural antioxidant, which is necessary for resisting aging, preventing diseases and preventing cancers: caffeic acid (caffeic acid) can prevent arteriosclerosis; chlorogenic acid (chlorogenic acid) can effectively inhibit canceration and has weight reducing effect; other antioxidants such as quercitrin (quercetin), kaempferol (kaempferol), etc. are also effective substances for preventing cancer and resisting aging.
Xiang Ru has the actions of inducing sweat, relieving exterior syndrome, resolving dampness, regulating the middle warmer, inducing diuresis and alleviating edema. The main treatment is as follows: summer cold, cold fluid, headache, fever, aversion to cold, no sweating, fullness in the chest, abdominal pain, vomiting, diarrhea, edema and beriberi. It can induce sweat to relieve exterior syndrome, resolve dampness and harmonize middle energizer to relieve summer-heat, and promote lung qi to induce diuresis to alleviate edema. Similar to Ma Huang, it is also strong in potency and best for yin cold block of summer-heat and edema due to wind and water, so it is called Ma Huang Xia Yue. It can be used for treating acute gastroenteritis, abdominal pain, emesis, diarrhea, summer-autumn heatstroke, headache, fever, aversion to cold, anidrosis, cholera, edema, epistaxis, and halitosis.
Chrysanthemum is bitter in flavor and sweet in taste, and slightly cold in nature. Meridian tropism enters lung and liver meridians. Has the effects of dispelling wind, clearing heat, calming liver, improving eyesight, and clearing away heat and toxic materials. The chrysanthemum can be used as a medicine for treating diseases, and can prolong the life after being taken for a long time or drunk as chrysanthemum tea. The application comprises the following steps: wind-heat type common cold, early warm disease; vertigo due to liver yang, liver wind excess syndrome; conjunctival congestion and faint; sores and abscess, swelling and toxicity, etc.
Mulberry leaves are dry leaves of Morus alba L of Moraceae, and are bitter, sweet and cold in nature and taste. Meridian tropism enters lung and liver meridians. Has the effects of dispelling wind and heat, clearing lung-heat, moistening dryness, calming liver, improving eyesight, cooling blood and stopping bleeding. It can be used for treating wind-heat type common cold, early stage of epidemic febrile disease, cough due to lung heat, vertigo due to hyperactivity of liver-yang, conjunctival congestion, blurred vision, hemoptysis due to recklessly blood flow due to blood heat, and hematemesis.
The health-care tea takes the traditional Chinese medicine theory as guidance, combines with modern medical research, carefully selects raw materials from the health-care science perspective, scientifically composes the raw materials, achieves the health-care effect of reducing blood sugar, and has the health-care functions of beautifying, nourishing life, strengthening physique, preventing diseases and prolonging life. The health food prepared by the invention focuses on the integral conditioning and the internal conditioning of a human body, combines the health preserving science, has the health care effect of reducing blood sugar, and can promote the health and the longevity of the human body.
The formula principle of the invention is as follows: the black tea and the medlar are used as monarch drugs, the lucid ganoderma, the eucommia ulmoides and the chrysanthemum are used as minister drugs, the angelica, the honeysuckle and the mulberry leaves are used as assistant drugs, and the polygala tenuifolia, chia, the elsholtzia and the isomaltooligosaccharide are used as guide drugs to assist in improving the efficacy of the product in reducing blood sugar. The medicines are combined to play the efficacies of clearing heat and quenching thirst, nourishing yin and promoting the production of body fluid, nourishing yin and moistening dryness as well as moistening lung, clearing stomach and nourishing kidney; has the effects of benefiting qi, activating blood circulation, expelling toxin and beautifying, and can be used for refreshing and moistening skin and beautifying face. The invention selects raw materials to condition the five internal organs of the human body, and the comprehensive effect achieves the health care effect of quenching thirst and reducing blood sugar. Wherein heart qi is vigorous and heart blood is full by regulating heart; the liver governs storing blood and harmonizes qi and blood by regulating the liver; the spleen is the acquired root and the source of qi and blood; the functions of the spleen and the stomach are healthy and healthy through regulating the spleen and the stomach, and qi and blood are vigorous; the lung governs the skin and hair, and regulates the lung to distribute qi, blood and body fluids throughout the body; kidneys store essence, and regulate kidneys to make kidney essence sufficient, so that when kidney qi is vigorous, the five internal organs function normally, qi and blood are vigorous, and the body is strengthened.
The health food of the invention is a fashion pursuit and also considers the traditional drinking mode, thus achieving the purpose of being beneficial to the health care of middle-aged and elderly people and sub-healthy people in pleasure. The health food has mild effect, stable drug effect and no toxic or side effect, and is suitable for long-term drinking. Researches show that the health food has the health-care effects of preventing hypertension and hyperlipidemia, resisting oxidation, delaying senility, improving immunity and the like after being taken for a long time.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
Example 1
A health food with blood sugar lowering function comprises raw materials of, by weight, 10 parts of black tea, 1 part of Chinese angelica, 5 parts of eucommia ulmoides, 10 parts of honeysuckle, 5 parts of lucid ganoderma, 10 parts of wolfberry fruit, 5 parts of polygala tenuifolia, 5 parts of chia, 5 parts of Chinese mosla herb, 10 parts of chrysanthemum, 5 parts of mulberry leaf and 0.1 part of isomaltooligosaccharide.
Example 2
A health food with blood sugar lowering function comprises, by weight, 200 parts of black tea, 10 parts of Chinese angelica, 50 parts of eucommia ulmoides, 200 parts of honeysuckle, 50 parts of lucid ganoderma, 150 parts of wolfberry fruit, 20 parts of polygala tenuifolia, 100 parts of chia, 50 parts of Chinese mosla herb, 200 parts of chrysanthemum, 100 parts of mulberry leaf and 1 part of isomaltooligosaccharide.
Example 3
A health food with blood sugar lowering function comprises, by weight, 150 parts of black tea, 2 parts of angelica sinensis, 10 parts of eucommia ulmoides, 150 parts of honeysuckle, 10 parts of lucid ganoderma, 120 parts of wolfberry fruit, 10 parts of polygala tenuifolia, 10 parts of chia, 40 parts of elsholtzia, 150 parts of chrysanthemum, 80 parts of mulberry leaves and 0.8 part of isomaltooligosaccharide.
Example 4
A health food with blood sugar lowering function comprises, by weight, 50 parts of black tea, 8 parts of Chinese angelica, 40 parts of eucommia ulmoides, 50 parts of honeysuckle, 40 parts of lucid ganoderma, 50 parts of wolfberry fruit, 15 parts of polygala tenuifolia, 80 parts of chia, 10 parts of Chinese mosla herb, 50 parts of chrysanthemum, 10 parts of mulberry leaf and 0.2 part of isomaltooligosaccharide.
Example 5
A health food with blood sugar lowering function comprises, by weight, 120 parts of black tea, 3 parts of angelica sinensis, 15 parts of eucommia ulmoides, 70 parts of honeysuckle, 15 parts of lucid ganoderma, 80 parts of wolfberry fruit, 12 parts of polygala tenuifolia, 50 parts of chia, 30 parts of elsholtzia, 85 parts of chrysanthemum, 60 parts of mulberry leaves and 0.6 part of isomaltooligosaccharide.
Example 6
The formula of the health food with the function of reducing blood sugar is the same as that in example 1, and the preparation method of the health food comprises the following steps:
1) preparing materials; weighing the required raw materials according to the proportion;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, adding 5 times of 90% ethanol, reflux-extracting for 3 times (each time for 0.5 hr), filtering, mixing filtrates, concentrating the filtrate to fluid extract (relative density of 1.30, 30 deg.C), adding ethanol to make ethanol content reach 75% to obtain solution I;
3) mixing black tea, flos Lonicerae, fructus Lycii, flos Chrysanthemi, and folium Mori, adding 5 times of water, decocting for 3 times, each time for 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to fluid extract (relative density of 1.30, 30 deg.C), adding ethanol to make ethanol content reach 75% to obtain solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract (with relative density of 1.30 at 30 deg.C); adding isomaltooligosaccharides according to a formula to prepare an active mixture; taking 100 parts of the active mixture, adding 12.5 parts of maltodextrin and 55.5 parts of microcrystalline cellulose, uniformly mixing, adding a proper amount of ethanol solution to prepare a soft material, granulating by using a 16-mesh sieve, drying at 60 ℃, and finishing granules by using a 12-mesh sieve to obtain the granules.
The product specification is 20 g/bag; the recommended eating method and the eating amount are as follows: the preparation is administered with warm boiled water 2 times a day, 1 bag each time; the shelf life is 24 months; the storage method is normal temperature, ventilation and dry place.
Example 7
The formula of the health food with the function of reducing blood sugar is the same as that in example 2, and the preparation method of the health food comprises the following steps:
1) preparing materials; weighing the required raw materials according to the proportion;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, adding 10 times of 50% ethanol, reflux-extracting for 1 time (each time for 3.0 hr), filtering, mixing filtrates, concentrating the filtrate to fluid extract (relative density of 1.10, 30 deg.C), adding ethanol to make ethanol content reach 70% to obtain solution I;
3) mixing black tea, flos Lonicerae, fructus Lycii, flos Chrysanthemi, and folium Mori, adding 15 times of water, decocting for 1 time, each time for 2 hr, mixing decoctions, filtering, concentrating the filtrate to fluid extract (relative density of 1.10, 30 deg.C), adding ethanol to make ethanol content reach 70% to obtain solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract (with relative density of 1.10 at 30 deg.C); adding isomaltooligosaccharides according to a formula to prepare an active mixture; taking 100 parts of the active mixture, adding 12.5 parts of maltodextrin and 55.5 parts of microcrystalline cellulose, uniformly mixing, adding a proper amount of ethanol solution to prepare a soft material, granulating by using a 16-mesh sieve, drying at 60 ℃, and finishing granules by using a 12-mesh sieve to obtain the granules.
The product specification is 20 g/bag; the recommended eating method and the eating amount are as follows: the preparation is administered with warm boiled water 2 times a day, 1 bag each time; the shelf life is 24 months; the storage method is normal temperature, ventilation and dry place.
Example 8
The formula of the health food with the function of reducing blood sugar is the same as that in example 3, and the preparation method of the health food comprises the following steps:
1) preparing materials; weighing the required raw materials according to the proportion;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, reflux-extracting with 70% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for 1 time, extracting with 6 times of ethanol for 1 hr for 2 times, filtering, mixing filtrates, concentrating the filtrate to fluid extract (relative density of 1.10, 30 deg.C), adding ethanol to make ethanol content reach 70% to obtain solution I;
3) mixing black tea, honeysuckle, medlar, chrysanthemum and mulberry leaves, adding water, decocting for 2 times, adding 10 times of water by weight for 2 hours for the 1 st time, adding 8 times of ethanol by weight for extracting for 1 hour for the 2 nd time, mixing decoctions, filtering, concentrating the filtrate to obtain clear paste (the relative density is 1.10, 30 ℃), adding ethanol until the ethanol content reaches 70%, and obtaining a solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract (with relative density of 1.10 at 30 deg.C); adding isomaltooligosaccharides according to a formula to prepare an active mixture; taking 100 parts of the active mixture, adding 12.5 parts of maltodextrin and 55.5 parts of microcrystalline cellulose, uniformly mixing, adding a proper amount of ethanol solution to prepare a soft material, granulating by using a 16-mesh sieve, drying at 60 ℃, and finishing granules by using a 12-mesh sieve to obtain the granules.
The product specification is 20 g/bag; the recommended eating method and the eating amount are as follows: the preparation is administered with warm boiled water 2 times a day, 1 bag each time; the shelf life is 24 months; the storage method is normal temperature, ventilation and dry place.
Example 9
The formula of the health food with the function of reducing blood sugar is the same as that in example 5, and the preparation method of the health food comprises the following steps:
1) preparing materials; weighing the required raw materials according to the proportion;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, reflux-extracting with 75% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for 1 time, extracting with 6 times of ethanol for 1 hr for 2 times, filtering, mixing filtrates, concentrating the filtrate to fluid extract (relative density of 1.30, 30 deg.C), adding ethanol to make ethanol content reach 75% to obtain solution I;
3) mixing black tea, honeysuckle, medlar, chrysanthemum and mulberry leaves, adding water, decocting for 2 times, adding 10 times of water by weight for 2 hours for the 1 st time, adding 8 times of ethanol by weight for extracting for 1 hour for the 2 nd time, mixing decoctions, filtering, concentrating the filtrate to obtain clear paste (the relative density is 1.30, 30 ℃), adding ethanol until the ethanol content reaches 75%, and obtaining a solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract (with relative density of 1.30 at 30 deg.C); adding isomaltooligosaccharides according to a formula to prepare an active mixture; taking 100 parts of the active mixture, adding 12.5 parts of maltodextrin and 55.5 parts of microcrystalline cellulose, uniformly mixing, adding a proper amount of ethanol solution to prepare a soft material, granulating by using a 16-mesh sieve, drying at 60 ℃, and finishing granules by using a 12-mesh sieve to obtain the granules.
The product specification is 20 g/bag; the recommended eating method and the eating amount are as follows: the preparation is administered with warm boiled water 2 times a day, 1 bag each time; the shelf life is 24 months; the storage method is normal temperature, ventilation and dry place.
Example 10
A health food with blood sugar lowering effect is prepared according to the same method as in example 9, except that the formula of the health food is the same as in example 4.
The product specification is 20 g/bag; the recommended eating method and the eating amount are as follows: the preparation is administered with warm boiled water 2 times a day, 1 bag each time; the shelf life is 24 months; the storage method is normal temperature, ventilation and dry place.
Example 11
A health food with blood sugar lowering function has the same formula as example 1, and is a bagged tea prepared by a conventional method.
Example 12
A health food with blood sugar lowering function has the same formula as example 2, and is a capsule prepared by a conventional method.
Example 13
A health food with blood sugar lowering effect is prepared by preparing active mixture according to the method of example 8, and mixing the active mixture with the rest materials to obtain a mixture; making into tablet by conventional method.
Example 14
A health food with blood sugar lowering effect is prepared by preparing active mixture according to the method of example 9, and mixing the active mixture with the above active mixture to obtain a mixture; making into capsule by conventional method.
Example 15
A health food with blood sugar lowering effect is prepared by preparing active mixture according to the method of example 8, and mixing the active mixture with the above active mixture to obtain a mixture; making into tablet by conventional method.
Comparative example
A black tea granule contains only black tea as active ingredient; the preparation method is the same as that of example 9 (except that the raw materials do not include traditional Chinese medicinal materials except dark tea and isomaltooligosaccharide).
Experimental example hypoglycemic function test
1. The test population: 100 adult type II diabetics, 18-65 years old, male and female halves, were selected. The inclusion standard of the subject is that the age is 18-65 years, the state of illness is stable after diet control or oral hypoglycemic drug treatment, the variety and the dosage of the drug do not need to be changed, only adult type II diabetics with maintenance dose are taken, and the fasting blood sugar is more than or equal to 7.8mmol/L or the 2h blood sugar is more than or equal to 11.1mmol/L after meal.
2. Experimental design and grouping: the test group and the control group are randomly divided according to the blood sugar level, sex, age, disease course and medicine taking type of the testee, and each group contains 50 people.
3. The test method comprises the following steps: the experimental group took the sample prepared in example 9 of the present invention every day, 2 times a day, 1 bag (20 g/bag) each time, and drunk after being infused with boiling water. The control group takes the dark tea granules prepared in the comparative example, and the dosage and the method of the control group are the same as those of the experimental group. The test period was 30 days. Before the test, each subject is fed with corresponding diet according to sex, age, different labor intensity and ideal weight according to the original living habits, and during the test period, the diet control is adhered to by each group, and the species and dosage of the original medicines are unchanged.
4. And (4) observing the effect: clinical symptoms were observed during the test period of the subjects, and fasting blood glucose, postprandial blood glucose, and urine glucose were measured.
5. Test results
5.1 Observation of clinical symptoms
TABLE 1 clinical symptom score statistics (x + -s)
| Group of | Number of examples | Before tasting | After eating trial |
| Control group | 50 | 5.59±3.27 | 5.47±3.12 |
| Experimental group | 50 | 5.73±3.41 | 3.65±2.61*# |
Note: p < 0.05 compared to experimental groups; comparison of # with control P < 0.05.
TABLE 2 improvement of clinical symptoms
As can be seen from tables 1 and 2, the clinical symptoms of the experimental group are obviously improved, and the difference is obvious compared with the control group (P is less than 0.05).
5.2 fasting blood glucose
TABLE 3 fasting plasma glucose change before and after tasting (unit: mmol/L, x. + -.s)
| Group number (n) | Before tasting | After eating trial | Extent of blood glucose decline | Percent reduction% |
| Control group 50 | 9.10±2.00 | 9.06±2.03 | 0.03±0.22 | 0.44 |
| Experimental group 50 | 9.13±2.11 | 7.97±2.02*# | 1.15±0.51*# | 12.71 |
Note: p < 0.05 compared to experimental groups; comparison of # with control P < 0.05.
5.3 postprandial blood glucose
TABLE 4 postprandial blood glucose Change before and after tasting (unit: mmol/L, x. + -. s)
| Group number (n) | Before tasting | After eating trial | Extent of blood glucose decline | Percent reduction% |
| Control group 50 | 12.20±2.11 | 12.15±2.05 | 0.05±0.25 | 0.41 |
| Experimental group 50 | 12.23±2.21 | 11.09±2.24*# | 1.13±0.62*# | 9.32 |
Note: p < 0.05 compared to experimental groups; comparison of # with control group P < 0.05
6. Conclusion
The experiment group takes the sample of the invention in the example 9, which has obvious improvement effect on the main clinical symptoms of hyperglycemia; the differences of fasting blood sugar, postprandial blood sugar and urine sugar of the experimental group before and after the test eating and the experimental group and the control group are significant (P is less than 0.05). The test result shows that the product of the invention has the health care function of reducing blood sugar.
In addition, the invention adopts pure natural medicines, does not add any toxic additive and addictive medicine, can not inhibit appetite, can not cause diarrhea, has no toxic or side effect, and is not addicted. In the experiment, the weight of most experimental subjects is reduced, the blood fat and the blood pressure are reduced to different degrees, the digestion is improved, the mental appearance is obviously improved, and the health-care effects of reducing the blood fat, the blood pressure, the weight loss and the like are prompted.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (4)
1. The preparation method of the health food for assisting in reducing blood sugar is characterized by comprising the following steps of:
1) preparing materials;
the health food comprises the following raw materials: 50-150 parts of dark green tea, 2-8 parts of angelica, 10-40 parts of eucommia bark, 50-150 parts of honeysuckle, 10-40 parts of lucid ganoderma, 50-120 parts of medlar, 10-15 parts of polygala root, 10-80 parts of chia, 10-40 parts of elsholtzia, 50-150 parts of chrysanthemum, 10-80 parts of mulberry leaf and 0.2-0.8 part of isomaltooligosaccharide;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, adding 5-10 times of 50-90% ethanol, reflux extracting for 1-3 times (0.5-3.0 hr each time), filtering, mixing filtrates, concentrating the filtrate to fluid extract, adding ethanol to make ethanol content reach 70-75%, to obtain solution I;
3) mixing black tea, honeysuckle, medlar, chrysanthemum and mulberry leaves, adding water with the weight of 5-15 times, decocting for 1-3 times, each time for 0.5-2 hours, merging decoction, filtering, concentrating filtrate into clear paste, adding ethanol until the ethanol content reaches 70% -75%, and obtaining solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract; adding isomaltooligosaccharide and appropriate amount of adjuvants according to the formulation to make into appropriate dosage form.
2. The preparation method of the auxiliary hypoglycemic health food as claimed in claim 1, wherein the auxiliary materials in step 4) are microcrystalline cellulose and magnesium stearate; the dosage form is granules.
3. The preparation method of the health-care food for assisting in reducing blood sugar according to claim 1, which comprises the following steps:
1) preparing materials;
2) mixing radix Angelicae sinensis, Eucommiae cortex, Ganoderma, cortex et radix Polygalae, chia and herba Moslae, reflux-extracting with 70% -75% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for 1 time, extracting with 6 times of ethanol for 1 hr for 2 times, filtering, mixing filtrates, concentrating the filtrate to fluid extract, adding ethanol to make ethanol content reach 70% -75%, to obtain solution I;
3) mixing black tea, honeysuckle, medlar, chrysanthemum and mulberry leaves, adding water, decocting for 2 times, adding 10 times of water by weight for 2 hours for the 1 st time, adding 8 times of ethanol by weight for extracting for 1 hour for the 2 nd time, mixing decoctions, filtering, concentrating the filtrate into clear paste, adding ethanol to enable the ethanol content to reach 70% -75%, and obtaining a solution II;
4) mixing the solution I and the solution II, stirring, standing, filtering, recovering ethanol from the filtrate, and concentrating to obtain fluid extract; adding isomaltooligosaccharide and appropriate amount of adjuvants according to the formulation to make into appropriate dosage form.
4. The preparation method of the health food for assisting in reducing blood sugar according to any one of claims 1 to 3, wherein the raw materials of the health food are: 120 parts of dark tea, 3 parts of angelica, 15 parts of eucommia bark, 70 parts of honeysuckle, 15 parts of lucid ganoderma, 80 parts of medlar, 12 parts of polygala root, 50 parts of chia, 30 parts of Chinese mosla herb, 85 parts of chrysanthemum, 60 parts of mulberry leaf and 0.6 part of isomaltooligosaccharide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910901417.8A CN110664906B (en) | 2016-02-01 | 2016-02-01 | Preparation method of health food with blood sugar reducing function |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910901417.8A CN110664906B (en) | 2016-02-01 | 2016-02-01 | Preparation method of health food with blood sugar reducing function |
| CN201610068808.2A CN105708970B (en) | 2016-02-01 | 2016-02-01 | A kind of health food with function of blood sugar reduction |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610068808.2A Division CN105708970B (en) | 2016-02-01 | 2016-02-01 | A kind of health food with function of blood sugar reduction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110664906A CN110664906A (en) | 2020-01-10 |
| CN110664906B true CN110664906B (en) | 2021-11-02 |
Family
ID=56154576
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910901417.8A Active CN110664906B (en) | 2016-02-01 | 2016-02-01 | Preparation method of health food with blood sugar reducing function |
| CN201910900400.0A Active CN110613134B (en) | 2016-02-01 | 2016-02-01 | Health food with blood sugar reducing function and preparation method thereof |
| CN201610068808.2A Active CN105708970B (en) | 2016-02-01 | 2016-02-01 | A kind of health food with function of blood sugar reduction |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910900400.0A Active CN110613134B (en) | 2016-02-01 | 2016-02-01 | Health food with blood sugar reducing function and preparation method thereof |
| CN201610068808.2A Active CN105708970B (en) | 2016-02-01 | 2016-02-01 | A kind of health food with function of blood sugar reduction |
Country Status (1)
| Country | Link |
|---|---|
| CN (3) | CN110664906B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106172965A (en) * | 2016-06-30 | 2016-12-07 | 安化盈泰丰农业发展有限公司 | A kind of novel ANHUA HEI CHA of natural environmental-protective U.S. face and preparation method thereof |
| CN106418529A (en) * | 2016-08-02 | 2017-02-22 | 马佳 | Preparation method of chrysanthemum oral liquid capable of improving immunity and oral liquid thereof |
| CN108260682A (en) * | 2018-01-16 | 2018-07-10 | 刘畅 | A kind of hypoglycemic, reducing blood lipid and the health protection tea of blood pressure lowering |
| JP2019022520A (en) * | 2018-10-19 | 2019-02-14 | 株式会社東洋新薬 | Composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101233912A (en) * | 2007-10-24 | 2008-08-06 | 杨啸 | Health care functional common salt |
| CN103141606A (en) * | 2013-03-12 | 2013-06-12 | 胡孔佑 | Instant dark green tea for nourishing blood and tonifying qi and preparation method thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002370994A (en) * | 2001-06-08 | 2002-12-24 | Kirin Brewery Co Ltd | Blood sugar value elevation-inhibiting substance and functional beverage or food containing the same |
| CN1274242C (en) * | 2004-08-12 | 2006-09-13 | 陈希萍 | Method for preparing probiotics product based on human somatology |
| CN1305405C (en) * | 2004-12-09 | 2007-03-21 | 桂林莱茵生物制品有限公司 | Health food with subsidiary function of lowering blood sugar and lowering blood fat and its production process |
| CN1660387A (en) * | 2004-12-29 | 2005-08-31 | 韦平生 | Health care preparation for regulating functional balance of organs of bowels in human body and preparing method |
| CN1915050B (en) * | 2006-08-31 | 2010-05-12 | 王学清 | Ganoderma lucidum tea and processing technique |
| CN101401601B (en) * | 2006-10-18 | 2011-01-26 | 吴建生 | Five-leaf tea for reducing blood pressure, blood fat and blood sugar |
| CN102919836B (en) * | 2012-11-09 | 2015-04-22 | 刘东元 | Health-care product capable of reducing blood glucose, releasing pressure, reducing lipid, relaxing bowel, beautifying, losing weight and resisting fatigue and production process thereof |
| CN103315090B (en) * | 2013-07-11 | 2014-06-11 | 山东华夏茶联茶业有限公司 | Preparation method of dark tea |
| CN103705578B (en) * | 2013-12-18 | 2015-09-02 | 广西中医药大学 | There is blood fat reducing and Chinese medicine preparation suppressing blood glucose rising effect and preparation method thereof |
-
2016
- 2016-02-01 CN CN201910901417.8A patent/CN110664906B/en active Active
- 2016-02-01 CN CN201910900400.0A patent/CN110613134B/en active Active
- 2016-02-01 CN CN201610068808.2A patent/CN105708970B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101233912A (en) * | 2007-10-24 | 2008-08-06 | 杨啸 | Health care functional common salt |
| CN103141606A (en) * | 2013-03-12 | 2013-06-12 | 胡孔佑 | Instant dark green tea for nourishing blood and tonifying qi and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105708970B (en) | 2019-08-23 |
| CN105708970A (en) | 2016-06-29 |
| CN110664906A (en) | 2020-01-10 |
| CN110613134A (en) | 2019-12-27 |
| CN110613134B (en) | 2022-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107296949A (en) | Integration of drinking and medicinal herbs compound formulation and its preparation method and application | |
| CN111956753B (en) | Medicinal and edible traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN110664906B (en) | Preparation method of health food with blood sugar reducing function | |
| CN106035861A (en) | Inonotus obliquus substitutional tea with health-care functions and preparation method thereof | |
| CN107156590A (en) | Vegetable solid beverage and preparation method thereof | |
| CN112314819A (en) | Plant beverage for improving sleep and preparation method thereof | |
| CN102920806B (en) | Nerve-soothing blood-pressure-reducing traditional Chinese medicine tea | |
| CN106333010A (en) | Bagged weight-losing and slimming tea and making method thereof | |
| CN111840394B (en) | Pharmaceutical composition for insomnia and preparation method thereof | |
| CN106343091A (en) | Weight-loss herbal tea beverage and preparation method thereof | |
| CN108813501A (en) | With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung | |
| CN107998240A (en) | A kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind and preparation method thereof | |
| CN101190250B (en) | Chewable tablets for preventing and controlling high-altitude disease and preparation method thereof | |
| CN104225295B (en) | Composition for improving sleep, and preparation method and application thereof | |
| CN102640920A (en) | Dietary cosmetic tea granules | |
| CN105596551A (en) | Traditional Chinese medicine composition having asthenopia relieving function and preparation method thereof | |
| CN108403933A (en) | A kind of time of childbirth meal is stimulated the secretion of milk qi-blood tonifying Chinese medicine composition of rehabilitation and preparation method thereof | |
| CN105995711A (en) | Fructus phyllanthi compound preparation and preparation method thereof | |
| CN103689602B (en) | Method for preparing Korean-red-ginseng oral liquid | |
| CN110916036A (en) | Liquor and preparation method thereof | |
| CN108967618A (en) | Inonotus obliquus health protection tea and preparation method thereof and application | |
| CN108478739A (en) | A kind of health products and preparation method thereof adjusting equilibrium between yin and yang | |
| CN116251152B (en) | Traditional Chinese medicine composition for growing and blackening hair, preparation method and application of traditional Chinese medicine preparation | |
| CN101274080A (en) | A composition method of antibacterial tablet for eliminating acne and clearing pathogenic fire and toxic materials | |
| CN104940427B (en) | Blood sugar reducing composition containing wolfberry fruits and application and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |