CN106177190A - A kind of guttural tablets and preparation method thereof - Google Patents
A kind of guttural tablets and preparation method thereof Download PDFInfo
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- CN106177190A CN106177190A CN201610667123.XA CN201610667123A CN106177190A CN 106177190 A CN106177190 A CN 106177190A CN 201610667123 A CN201610667123 A CN 201610667123A CN 106177190 A CN106177190 A CN 106177190A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 38
- 239000000284 extract Substances 0.000 claims abstract description 95
- 210000000582 semen Anatomy 0.000 claims abstract description 19
- 229940094952 green tea extract Drugs 0.000 claims abstract description 18
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 18
- 241000628997 Flos Species 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000012467 final product Substances 0.000 claims description 13
- 235000019359 magnesium stearate Nutrition 0.000 claims description 12
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 235000009569 green tea Nutrition 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 241000205585 Aquilegia canadensis Species 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 235000014435 Mentha Nutrition 0.000 claims description 3
- 241001072983 Mentha Species 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 239000004519 grease Substances 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- -1 hydrogen Sodium hydroxide Chemical class 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 1
- 229920000157 polyfructose Polymers 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 3
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract description 3
- 210000001124 body fluid Anatomy 0.000 abstract description 3
- 239000010839 body fluid Substances 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 208000026435 phlegm Diseases 0.000 abstract description 3
- 231100000614 poison Toxicity 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 239000003440 toxic substance Substances 0.000 abstract description 3
- 229930006000 Sucrose Natural products 0.000 abstract description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 229960004793 sucrose Drugs 0.000 abstract description 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 19
- 210000003800 pharynx Anatomy 0.000 description 11
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 229920003081 Povidone K 30 Polymers 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 229940046011 buccal tablet Drugs 0.000 description 2
- 239000006189 buccal tablet Substances 0.000 description 2
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000029951 Laryngeal disease Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006068 taste-masking agent Substances 0.000 description 1
- 210000001260 vocal cord Anatomy 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention proposes a kind of guttural tablets and preparation method thereof, and described guttural tablets includes the raw material composition of following parts by weight: raw material includes green tea extract 5～20 parts, Radix Scutellariae extract 5～20 parts, Flos Lonicerae extract 5～20 parts, Radix Glycyrrhizae extract 2～10 parts, Semen Sterculiae Lychnophorae extract 2～10 parts, Folium Menthae extract 0.2～2 parts by weight.By above raw material by after technological requirement extraction process, add suitable adjuvant, require to be prepared from according to tablet producing technology.The all medicines of the present invention share, and meet the requirement of traditional Chinese medical science medical knowledge and modern pharmacology, reach effect of heat-clearing and toxic substances removing, dispelling phlegm and relieving sore-throat, YIN nourishing and the production of body fluid promoting.And supplementary material used is no cane sugar type, it is suitable for diabetics and obese people is taken.The preparation method technique that the present invention provides is simple, is suitable for industrialized production.
Description
Technical field
The present invention relates to Chinese medicine and field of health care products, particularly to a kind of guttural tablets and preparation method thereof.
Background technology
The pharyngeal channel design common as respiratory tract and digestive tract, for extraneous various chemical factors, biological factor all
Extremely easily infringement pharynx mucosa, causes swallowing mucosa and is inflamed, produce pharyngolaryngitis.Along with growth in the living standard, the drink of people
Feeding habits has a very large change the most therewith.Pungent diet and the stimulation of tobacco and wine, make laryngopharyngeal diseases sickness rate substantially increase, and becomes
A big factor for being detrimental to health.Not only affect people during laryngopharyngeal diseases morbidity and carry out Verbal interaction and sleep, and swallow
The pathological change that causes of active chronic inflammation, not only cause the malfunction of pharynx local, it is possible to involve neighbouring organ-tissue, lure
Send out other diseases.Owing to the harm of laryngopharyngeal diseases is very big, throat expert advice, laryngopharyngeal diseases prevented and controls, will be placed on anti-
Emphasis, it is important that enhancing body defence capability.Moistening and cleaning throat health food had both had the nutrition general character of normal food, had again antiinflammatory
Antibacterial, the cough-relieving that wets one's whistle, eliminate special roles such as swelling and ache, heat-clearing and toxic substances removing, recovery vocal cords are tired, can be used for throat health care, prevention pharynx
Laryngeal disease.Buccal tablet has taking convenience, some drugs by mucosal absorption without liver first-pass effect bioavailability high,
The advantage such as rapid-action.Therefore buccal tablet application is made at many of moistening and cleaning throat treatment and health field preparation.Guttural tablets has clearing throat,
Alleviating the function of throat discomfort, for acute/chronic pharyngitis, what laryngopharynx fatigue caused do, itch, swell and ache, the symptoms such as expectoration is not well.
The traditional Chinese medical science medical knowledge of function of moistening and cleaning throat is the effects such as heat-clearing and toxic substances removing, dispelling phlegm and relieving sore-throat, YIN nourishing and the production of body fluid promoting, modern pharmacology refer to antiinflammatory,
The effect such as antibacterial, antiviral and antipyretic, analgesia.The patent that published many is relevant to moistening and cleaning throat is all with traditional Chinese medical science medical knowledge as base
Plinth invention.For significantly more efficient prevention and treatment laryngopharyngeal diseases, the invention provides a kind of guttural tablets and preparation method.
Summary of the invention
It is an object of the invention to provide a kind of guttural tablets and preparation method.
For reaching above-mentioned purpose, specifically adopt the following technical scheme that:
A kind of guttural tablets, its raw material includes that green tea extract 5-20 part, Radix Scutellariae extract 5-20 part, Flos Lonicerae carry by weight
Take thing 5-20 part, Radix Glycyrrhizae extract 2-10 part, Semen Sterculiae Lychnophorae extract 2-10 part, Folium Menthae extract 0.2-2 part.
Preferably, its raw material includes that green tea extract 10-15 part, Radix Scutellariae extract 10-15 part, Flos Lonicerae carry by weight
Take thing 10-15 part, Radix Glycyrrhizae extract 4-8 part, Semen Sterculiae Lychnophorae extract 2-8 part, Folium Menthae extract 0.5-1 part.
It is furthermore preferred that its raw material includes green tea extract 15 parts, Radix Scutellariae extract 15 parts, Flos Lonicerae extract by weight
15 parts, Radix Glycyrrhizae extract 8 parts, Semen Sterculiae Lychnophorae extract 4 parts, Folium Menthae extract 1 part.
On the basis of above-mentioned raw materials composition, the present invention can also add 20～50 parts of excipient, 0.2～1 part of taste masking
Agent, 0.2～1 part of lubricant and then obtain guttural tablets.
Concrete, the one in oligofructose, Sorbitol, xylitol, mannitol or maltose chosen by described excipient
Or several, preferably oligofructose.
Described correctives chooses one or more in Mentholum, vitamin C, tartaric acid.
Described lubricant chooses one or more in micropowder silica gel, magnesium stearate, preferably magnesium stearate.
Present invention also offers the preparation method of described a kind of guttural tablets, its supplementary material of the guttural tablets of the present invention is pressed
Weight portion includes green tea extract 5-20 part, Radix Scutellariae extract 5-20 part, Flos Lonicerae extract 5-20 part, Radix Glycyrrhizae extract 2-10
Part, Semen Sterculiae Lychnophorae extract 2-10 part, Folium Menthae extract 0.2-2 part, oligofructose 20～50 parts, Mentholum 0.1～0.15 part, wine
Stone acid 0.1～0.2 part, magnesium stearate 0.2～1 part.
Described green tea extract, preparation method comprises the following steps: take green tea, is ground into coarse powder, adds 10 times amount
Drinking water 100 DEG C extraction, each 30 minutes, filters, and totally 2 times, merging filtrate, concentrated extract density is at 1.1-1.2, vacuum microwave
It is dried to moisture≤5.0%, pulverizes, cross 120 mesh sieves, obtain green tea extract.
Described Radix Scutellariae extract, preparation method comprises the following steps: takes Radix Scutellariae, boiling, collecting decoction, is concentrated into
In right amount, with salt acid for adjusting pH value to 1.0～2.0,80 DEG C of insulations, standing, filter, precipitate adds suitable quantity of water and stirs evenly, and uses 40% hydrogen
Sodium hydroxide solution regulation pH value, to 7.0, adds equivalent ethanol, is stirred to dissolve, filter, filtrate with salt acid for adjusting pH value to 1.0～
2.0,60 DEG C of insulations, stand, and filter, and precipitation is washed till pH value to 7.0 with the ethanol of suitable quantity of water and variable concentrations successively, waves most second
Alcohol, drying under reduced pressure, pulverize, cross 120 mesh sieves, to obtain final product.
Described Flos Lonicerae extract, preparation method comprises the following steps: extracting honeysuckle, adds 75% alcohol reflux two
Secondary, the most each 1 hour, united extraction liquid, be evaporated to relative density be 1.15～1.18(60 DEG C) clear paste, add ethanol and make
Alcohol content reaches 65%, stands 24 hours, takes supernatant, be evaporated to relative density be 1.15～1.18(60 DEG C), vacuum drying
To moisture≤5%, pulverize, cross 120 mesh sieves, to obtain final product.
Described Radix Glycyrrhizae extract is Radix Glycyrrhizae extractum, meets " Chinese Pharmacopoeia " regulation.
Described Semen Sterculiae Lychnophorae extract, its preparation method comprises the following steps: take Semen Sterculiae Lychnophorae, adds 12 times amount water, decocts two
Secondary, each 1.5 hours.Merging filtrate, is concentrated in vacuo and is dried to moisture≤5%, pulverize, cross 120 mesh sieves, to obtain final product.
Described Folium Menthae extract, preparation method comprises the following steps: take dry mentha leave, the water of 10 times amount that add water, and adopts
Extracting 6h by the atmospheric steam way of distillation, obtain the faint yellow grease with peat-reek, deepfreeze seals and preserves, i.e.
?.
Wherein, a kind of preferred forms of the present invention is: the supplementary material of described guttural tablets includes green tea by weight
Extract 15 parts, Radix Scutellariae extract 15 parts, Flos Lonicerae extract 15 parts, Radix Glycyrrhizae extract 8 parts, Semen Sterculiae Lychnophorae extract 4 parts, Herba Menthae
Extract 1 part, oligofructose 45 parts, Mentholum 0.2 part, 0.4 part of tartaric acid, magnesium stearate 1 part.
Further, the invention provides the preparation method of described guttural tablets, specifically include following steps:
The raw material (in addition to Folium Menthae extract) of above guttural tablets by weight, adds excipient mixing, makes granule, dry
Dry, cross 20 mesh sieves, be subsequently adding lubricant and correctives, after Folium Menthae extract sprays into, mixing, tabletting and get final product.
Guttural tablets of the present invention is with natural raw material of Chinese medicine as raw material, and all medicines share, and it is clear for meeting traditional Chinese medical science medical knowledge
The effects such as thermal detoxification, dispelling phlegm and relieving sore-throat, YIN nourishing and the production of body fluid promoting, and the effect such as modern pharmacology antiinflammatory, antibacterial, antiviral and antipyretic, analgesia.
And supplementary material used is no cane sugar type, it is suitable for diabetics and obese people is taken.The preparation method that the present invention provides
Technique is simple, is suitable for industrialized production.
Detailed description of the invention
Embodiment 1
A kind of guttural tablets and preparation method are carried out according to the following steps:
According to producing prescription requirements, weigh green tea extract 150g, Radix Scutellariae extract 150g, Flos Lonicerae extract 150g, Radix Glycyrrhizae
Extract 80g, Semen Sterculiae Lychnophorae extract 44g, Folium Menthae extract 10g, oligofructose 450g, Mentholum 2g, tartaric acid 4g, stearic acid
Magnesium 10g.The most each supplementary material (in addition to Folium Menthae extract, Mentholum, magnesium stearate) mixes at mixer, 8% 30 POVIDONE K 30 BP/USP30Ethanol
Solution makees binding agent granule, airpillow-dry, is subsequently adding Mentholum and magnesium stearate, after Folium Menthae extract sprays into, in three-dimensional
Mixing in movement mixer, on tablet machine, 1000, the tablet of 1.05g made by tabletting.
Embodiment 2
A kind of guttural tablets and preparation method are carried out according to the following steps:
According to producing prescription requirements, weigh green tea extract 150g, Radix Scutellariae extract 175g, Flos Lonicerae extract 125g, Radix Glycyrrhizae
Extract 80g, Semen Sterculiae Lychnophorae extract 50g, Folium Menthae extract 4g, oligofructose 450g, Mentholum 2g, vitamin C 4g, stearic acid
Magnesium 10g.The most each supplementary material (in addition to Folium Menthae extract, Mentholum, magnesium stearate) mixes at mixer, 8% 30 POVIDONE K 30 BP/USP30Ethanol
Solution makees binding agent granule, airpillow-dry, is subsequently adding Mentholum and magnesium stearate, after Folium Menthae extract sprays into, in three-dimensional
Mixing in movement mixer, on tablet machine, 1000, the tablet of 1.05g made by tabletting.
Green tea extract described in above-described embodiment 1 and 2, Radix Scutellariae extract, Flos Lonicerae extract, Radix Glycyrrhizae extract,
Semen Sterculiae Lychnophorae extract, Folium Menthae extract are prepared as follows:
Described green tea extract, preparation method comprises the following steps: take green tea, is ground into coarse powder, adds drinking of 10 times amount
The extraction of 100 DEG C of water, each 30 minutes, filters, and totally 2 times, merging filtrate, concentrated extract density is at 1.1-1.2, vacuum microwave drying
To moisture≤5.0%, pulverize, cross 120 mesh sieves, obtain green tea extract.
Described Radix Scutellariae extract, preparation method comprises the following steps: takes Radix Scutellariae, boiling, collecting decoction, is concentrated into
In right amount, with salt acid for adjusting pH value to 1.0～2.0,80 DEG C of insulations, standing, filter, precipitate adds suitable quantity of water and stirs evenly, and uses 40% hydrogen
Sodium hydroxide solution regulation pH value, to 7.0, adds equivalent ethanol, is stirred to dissolve, filter, filtrate with salt acid for adjusting pH value to 1.0～
2.0,60 DEG C of insulations, stand, and filter, and precipitation is washed till pH value to 7.0 with the ethanol of suitable quantity of water and variable concentrations successively, waves most second
Alcohol, drying under reduced pressure, pulverize, cross 120 mesh sieves, to obtain final product.
Described Flos Lonicerae extract, preparation method comprises the following steps: extracting honeysuckle, adds 75% alcohol reflux two
Secondary, the most each 1 hour, united extraction liquid, be evaporated to relative density be 1.15～1.18(60 DEG C) clear paste, add ethanol and make
Alcohol content reaches 65%, stands 24 hours, takes supernatant, be evaporated to relative density be 1.15～1.18(60 DEG C), vacuum drying
To moisture≤5%, pulverize, cross 120 mesh sieves, to obtain final product.
Described Radix Glycyrrhizae extract is Radix Glycyrrhizae extractum, meets " Chinese Pharmacopoeia " regulation.Pulverize, cross 120 mesh sieves, to obtain final product.
Described Semen Sterculiae Lychnophorae extract, its preparation method comprises the following steps: take Semen Sterculiae Lychnophorae, adds 12 times amount water, decocts two
Secondary, each 1.5 hours.Merging filtrate, is concentrated in vacuo and is dried to moisture≤5%, pulverize, cross 120 mesh sieves, to obtain final product.
Described Folium Menthae extract, preparation method comprises the following steps: take dry mentha leave, the water of 10 times amount that add water, and adopts
Extracting 6h by the atmospheric steam way of distillation, obtain the faint yellow grease with peat-reek, deepfreeze seals and preserves, i.e.
?.
Although, the present invention is described in detail the most with a general description of the specific embodiments, but in the present invention
On the basis of, it can be made some modifications or improvements, this is apparent from for professional and technical personnel in the field.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (9)
1. guttural tablets and preparation method thereof, it is characterised in that its raw material include by weight green tea extract 5-20 part,
Radix Scutellariae extract 5-20 part, Flos Lonicerae extract 5-20 part, Radix Glycyrrhizae extract 2-10 part, Semen Sterculiae Lychnophorae extract 2-10 part, Herba Menthae
Extract 0.2-2 part.
A kind of guttural tablets the most according to claim 1 and preparation method thereof, it is characterised in that its raw material wraps by weight
Include green tea extract 10-15 part, Radix Scutellariae extract 10-15 part, Flos Lonicerae extract 10-15 part, Radix Glycyrrhizae extract 4-8 part, fat
Sea extract 2-8 part, Folium Menthae extract 0.5-1 part.
A kind of guttural tablets the most according to claim 2 and preparation method thereof, it is characterised in that its raw material wraps by weight
Include green tea extract 15 parts, Radix Scutellariae extract 15 parts, Flos Lonicerae extract 15 parts, Radix Glycyrrhizae extract 8 parts, Semen Sterculiae Lychnophorae extract 4
Part, Folium Menthae extract 1 part.
A kind of guttural tablets the most according to claims 1 to 3 and preparation method thereof, it is characterised in that described raw material is pressed
Following method is prepared:
(1) green tea extract described in, preparation method comprises the following steps: take green tea, is ground into coarse powder, adds the drink of 10 times amount
With the extraction of 100 DEG C of water, each 30 minutes, filtering, totally 2 times, merging filtrate, concentrated extract density is done at 1.1-1.2, vacuum microwave
Dry to moisture≤5.0%, pulverize, cross 120 mesh sieves, obtain green tea extract；
(2) Radix Scutellariae extract described in, preparation method comprises the following steps: takes Radix Scutellariae, boiling, collecting decoction, is concentrated into
In right amount, with salt acid for adjusting pH value to 1.0～2.0,80 DEG C of insulations, standing, filter, precipitate adds suitable quantity of water and stirs evenly, and uses 40% hydrogen
Sodium hydroxide solution regulation pH value, to 7.0, adds equivalent ethanol, is stirred to dissolve, filter, filtrate with salt acid for adjusting pH value to 1.0～
2.0,60 DEG C of insulations, stand, and filter, and precipitation is washed till pH value to 7.0 with the ethanol of suitable quantity of water and variable concentrations successively, waves most second
Alcohol, drying under reduced pressure, pulverize, cross 120 mesh sieves, to obtain final product；
(3) Flos Lonicerae extract described in, preparation method comprises the following steps: extracting honeysuckle, adds 75% alcohol reflux two
Secondary, the most each 1 hour, united extraction liquid, be evaporated to relative density be 1.15～1.18(60 DEG C) clear paste, add ethanol and make
Alcohol content reaches 65%, stands 24 hours, takes supernatant, be evaporated to relative density be 1.15～1.18(60 DEG C), vacuum drying
To moisture≤5%, pulverize, cross 120 mesh sieves, to obtain final product；
(4) Radix Glycyrrhizae extract described in is Radix Glycyrrhizae extractum, meets " Chinese Pharmacopoeia " regulation；
(5) Semen Sterculiae Lychnophorae extract described in, its preparation method comprises the following steps: take Semen Sterculiae Lychnophorae, adds 12 times amount water, decocts two
Secondary, each 1.5 hours, merging filtrate, it is concentrated in vacuo and is dried to moisture≤5%, pulverize, cross 120 mesh sieves, to obtain final product；
(6) Folium Menthae extract described in, preparation method comprises the following steps: take dry mentha leave, the water of 10 times amount that add water, and uses
The atmospheric steam way of distillation extracts 6h, obtains the faint yellow grease with peat-reek, and deepfreeze seals and preserves, and to obtain final product.
A kind of guttural tablets the most according to claims 1 to 3 and preparation method thereof, it is characterised in that also include 20～50
Part excipient, 0.2～1 part of correctives, 0.2～1 part of lubricant.
A kind of guttural tablets the most according to claim 5 and preparation method thereof, it is characterised in that described excipient is chosen low
One or more in Polyfructose., Sorbitol, xylitol, mannitol or maltose, preferably oligofructose, described correctives
Including one or more in Mentholum, vitamin C, tartaric acid, described lubricant is in magnesium stearate or micropowder silica gel
Kind, preferably magnesium stearate.
A kind of guttural tablets the most according to claims 1 to 4 and preparation method thereof, it is characterised in that its supplementary material is by weight
Amount part includes that 5-20 part, Radix Scutellariae extract 5-20 part, Flos Lonicerae extract 5-20 part, Radix Glycyrrhizae extract 2-10 part, Semen Sterculiae Lychnophorae carry
Take thing 2-10 part, Folium Menthae extract 0.2-2 part, oligofructose 20～50 parts, Mentholum 0.1～0.15 part, tartaric acid 0.1～
0.2 part, magnesium stearate 0.2～1 part.
A kind of guttural tablets the most according to claim 7 and preparation method thereof, it is characterised in that its supplementary material is by weight
Including green tea extract 15 parts, Radix Scutellariae extract 15 parts, Flos Lonicerae extract 15 parts, Radix Glycyrrhizae extract 8 parts, Semen Sterculiae Lychnophorae extract
4 parts, Folium Menthae extract 1 part, oligofructose 45 parts, Mentholum 0.2 part, 0.4 part of tartaric acid, magnesium stearate 1 part.
9. a kind of guttural tablets described in any one of claim 5～8 and preparation method thereof, it is characterised in that preparation method bag
Include following steps: raw material (in addition to Folium Menthae extract) by weight, adds excipient mixing, makes granule, be dried, cross 20 mesh
Sieve, is subsequently adding lubricant and correctives, after Folium Menthae extract sprays into, and mixing, tabletting and get final product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107712232A (en) * | 2017-12-02 | 2018-02-23 | 王艳萍 | A kind of green tea confection and preparation method thereof |
| CN107998240A (en) * | 2017-11-29 | 2018-05-08 | 广西优源生物科技有限公司 | A kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind and preparation method thereof |
| CN111685934A (en) * | 2020-07-17 | 2020-09-22 | 赣州市特可环保技术有限公司 | Eye shield with plant nano crystals and function of improving eyesight and preparation method of eye shield |
| CN115212163A (en) * | 2022-06-20 | 2022-10-21 | 杭州国茶健康产业有限公司 | Natural herbal tea buccal tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053352A (en) * | 2007-05-22 | 2007-10-17 | 浙江大学 | Buccal tablet and its preparation method |
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2016
- 2016-08-15 CN CN201610667123.XA patent/CN106177190A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053352A (en) * | 2007-05-22 | 2007-10-17 | 浙江大学 | Buccal tablet and its preparation method |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107998240A (en) * | 2017-11-29 | 2018-05-08 | 广西优源生物科技有限公司 | A kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind and preparation method thereof |
| CN107712232A (en) * | 2017-12-02 | 2018-02-23 | 王艳萍 | A kind of green tea confection and preparation method thereof |
| CN111685934A (en) * | 2020-07-17 | 2020-09-22 | 赣州市特可环保技术有限公司 | Eye shield with plant nano crystals and function of improving eyesight and preparation method of eye shield |
| CN115212163A (en) * | 2022-06-20 | 2022-10-21 | 杭州国茶健康产业有限公司 | Natural herbal tea buccal tablet and preparation method thereof |
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