CN103656410A - Traditional Chinese medicine preparation for treating cough and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating cough and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating cough and a preparation method thereof. The traditional Chinese medicine preparation consists of the following twelve Chinese herbal medicines: ephedra, radix stemonae, negundo chastetree fruit, affine cudweed, loquat seed dried powder, bezoar, radix polygonati officinalis, momordica grosvenori, radix puerariae, herb of savatier monochasma, manglietia fordiana and fig. The preparation method comprises the following steps: uniformly mixing a thick paste and dextrin of the medicine, taking ethanol as a wetting agent to prepare wet granules, drying, cooling, spraying volatile oil, and uniformly mixing, thereby obtaining the traditional Chinese medicine preparation. The preparation has good curative effects on symptoms such as cough, coughing up phlegm, fever with aversion to cold, headache without sweat, body ache and severe nasal obstruction caused by moderate and medium exogenous cold and unsmooth lung qi. Compared with the other process technologies, the medicine is simple and clear in composition and process, and the quality is easily controlled.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, especially a kind of Chinese medicine preparation for the treatment of cough and preparation method thereof.
Background technology
Cough is that human body is removed secretions in respiratory tract or the protectiveness respiratory reflex action of foreign body.But violent cough can cause respiratory tract hemorrhage, as for a long time, frequent, acutely cough and affect work, have a rest, even cause laryngalgia, hoarseness and breathing myalgia, be the cardinal symptom of respiratory system disease.The common disease that causes cough has upper respiratory tract infection, acute pharyngolaryngitis, bronchitis, pneumonia etc.Due to urban air environment worse and worse, clinical onset rate has the trend of continuous rising in recent years.
At present the conventional Chinese patent medicine for the treatment of cough clinically has a lot, and the cough in treatment, due to slight affection of exogenous wind-cold, inhibited pulmonary QI, coughs up phlegm, and fever with aversion to cold, has a headache lossless, and limb aching pain and nasal obstruction are low voice speaking waits disease to commonly use affection of exogenous wind-cold granule, affection of exogenous wind-cold ball etc.Said medicine differs from one another, and all has certain effect, but often falls flat.The present invention is based on the theoretical method of Chinese traditional treatment cough, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical tune, emergency is taken in concurrently, filter out the natural vegetable Chinese herbal medicine that clearing away lung-heat to relieve cough, cold expelling reduce phlegm, according to certain weight proportion, be prepared from, a kind of Chinese medicine preparation of evident in efficacy, with low cost, treatment cough that toxic and side effects is minimum is provided.
Summary of the invention
The object of this invention is to provide and be a kind ofly made into Chinese medicine preparation after the 12 taste Chinese herbal medicine extracting such as Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici are gone out to effective ingredient; for in, cough due to slight affection of exogenous wind-cold, inhibited pulmonary QI; cough up phlegm; fever with aversion to cold; have a headache lossless; limb aching pain, the low voice speaking disease such as grade of having a stuffy nose has reasonable therapeutic effect.
The technical solution used in the present invention is:
Treat a Chinese medicine preparation for cough, comprise the Chinese medicine of following composition by weight: 0.5 ~ 4 part of 1 ~ 6 part, 0.5 ~ 4 part, Herba Ephedrae, 0.5 ~ 4 part of the Radix Stemonae, 0.5 ~ 4 part of Fructus Viticis Negundo, 0.5 ~ 4 part of Herba Gnaphalii Affinis, 0.5 ~ 4 part, Radix Eriobotryae dry powder, 0.5 ~ 4 part of Calculus Bovis, 1 ~ 6 part of Rhizoma Polygonati Odorati, 1 ~ 6 part of Fructus Momordicae, 0.5 ~ 4 part of Radix Puerariae, 0.5 ~ 4 part of Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici.
Preferably; described a kind of Chinese medicine preparation for the treatment of cough, comprises the Chinese medicine of following composition by weight: 1.55 parts of 1 part, Herba Ephedrae, 1.67 parts of the Radixs Stemonae, 2.44 parts of Fructus Viticis Negundo, 1.54 parts of Herba Gnaphalii Affinis, 2.46 parts, Radix Eriobotryae dry powder, 3.45 parts of Calculus Boviss, 2.56 parts of Rhizoma Polygonati Odorati, 5.8 parts of Fructus Momordicaes, 3.2 parts of Radix Puerariaes, 2.4 parts of Herba monochasmatiss, 1.6 parts of Fructus Fici Pumilaes and Fructus Ficis.
Preferably; described a kind of Chinese medicine preparation for the treatment of cough, comprises the Chinese medicine of following composition by weight: 3.45 parts of 2 parts, Herba Ephedrae, 2.43 parts of the Radixs Stemonae, 2.44 parts of Fructus Viticis Negundo, 3.57 parts of Herba Gnaphalii Affinis, 1.49 parts, Radix Eriobotryae dry powder, 2.35 parts of Calculus Boviss, 3.43 parts of Rhizoma Polygonati Odorati, 4.51 parts of Fructus Momordicaes, 3.5 parts of Radix Puerariaes, 3.56 parts of Herba monochasmatiss, 2.55 parts of Fructus Fici Pumilaes and Fructus Ficis.
Preferably; described a kind of Chinese medicine preparation for the treatment of cough, comprises the Chinese medicine of following composition by weight: 1.3 parts of 2.5 parts, Herba Ephedrae, 3.5 parts of the Radixs Stemonae, 1.5 parts of Fructus Viticis Negundo, 2.6 parts of Herba Gnaphalii Affinis, 3.8 parts, Radix Eriobotryae dry powder, 1.2 parts of Calculus Boviss, 5.4 parts of Rhizoma Polygonati Odorati, 3.5 parts of Fructus Momordicaes, 1.6 parts of Radix Puerariaes, 2.4 parts of Herba monochasmatiss, 4.7 parts of Fructus Fici Pumilaes and Fructus Ficis.
According to Chinese medicine and modern pharmacology toxicity reported in literature, the effect of each component of Chinese medicine preparation of the present invention and the effect in prescription thereof are described below:
Herba Ephedrae
ephedra sinica Stapf, be Ephedraceae, Ephedra, is important medicinal plants, alkaloid is abundant, energy diaphoresis cold expelling, depressed lung-energy dispersing, is applicable to wind and cold sense stomach, cough, asthma.
The Radix Stemonae
stemona sessilifolia (Miq.) Miq, another name: Herba delphinii grandiflori, Angiospermae, is Stemonaceae plant Radix Stemonae.Radix Stemonae nature and flavor are sweet, bitter, and tepor is returned lung meridian, cure mainly nourishing the lung to keep the adverse QI downward cough-relieving, for new chronic cough, cough, and pulmonary tuberculosis cough, pertussis.
Fructus Viticis Negundo
vitex negundo L.,call cloth Fructus Vitics Simplicifoliae, gold, Folium vilicis Negundo, Radix Hydrangeae Strigosae, five-leaved chaste tree bar, derive from the fruit of Verbenaceae five-leaved chaste tree, energy relieving cough and asthma, loosening bowel to relieve constipation, is applicable to cough, expectoration, constipation.
Herba Gnaphalii Affinis
herba Gnaphaii Affinis,feverfew.While blooming, gather, dry, remove most impurity, the dry place of storage.Cure mainly and eliminate the phlegm, cough, relievings asthma, wind-damp dispelling.
Radix Eriobotryae dry powder, for Folium Eriobotryae (
eriobotrya japonica (Thunb.) Lindl.) seed, Radix Eriobotryae selenium is done, is smashed to pieces and make powder, has preventing phlegm from forming and stopping coughing, the effect of depressed liver-energy dispersing and QI regulating.
Calculus Bovis
calculus bovis, be the dry cholelithiasis of bovid cattle.Chinese medicine is thought Calculus Bovis gas delicate fragrance, and mildly bitter flavor is then sweet, cool in nature.Can be used for removing toxic substances, control laryngopharynx swelling and pain, eliminating pathogen from the lung for relieving asthma and cough with asthma.Because natural Calculus Bovis is very precious, can use artificial Calculus Bovis.
Rhizoma Polygonati Odorati
polygonatum odoratum (Mill.), be Liliaceae herbaceos perennial.The rhizome of plant can hyoscine, and Chinese medicine name is also Rhizoma Polygonati Odorati, and excavate autumn, cleans, and shines to softness, repeatedly rubs, and dry in the sun, to without hard-core, is dried, or after steaming thoroughly, rubs to translucent, dries, and cuts sheet or section is used.Can control deficiency of YIN fire scorching, hemoptysis, cough, dry pharynx expectorant knot, the diseases such as aphonia.
Fructus Momordicae
corsvenor Momordica Fruit, be the distinctive cucurbitaceous plant of China, sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, and the effect of promoting the production of body fluid to quench thirst is applicable to lung-heat or xeropulmonary cough, and pertussis and summer-heat impairment of body fluid are thirsty etc., also have in addition the effect of loosening bowel to relieve constipation.Energy anti-inflammation, is applicable to various infection.
Radix Puerariae
lobed Kudzuvine Root, be the tuber of liana Herba Gelsemii Elegantis, be a kind of normal food vegetable of some provinces and regions of southern china, its sweet in the mouth is cool good to eat, can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, clinically treats flu and upper respiratory tract infection, cough, expectoration with Radix Puerariae.
Herba monochasmatis
antlerpilose grass, be the dry herb of goatweed Herba monochasmatis, energy nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription, is applicable to cough and asthma, laryngopharynx swelling and pain.
Fructus Fici Pumilae
manglietia fordiana (Hemsl.) OliV., be Magnoliaceae Manglietia plant, have another name called gold zone tree.Fructus Fici Pumilae stem branch can be controlled as medical material, cures mainly that excess-fire is just closed, punish-old people dry cough.
Fructus Fici
ficus carica Linn, belong to Moraceae Ficus, Fructus Fici sweet in the mouth, property is flat, nontoxic, has spleen invigorating, nourishes the effect of intestine moistening.The contained lipase of Fructus Fici, hydrolytic enzyme etc. have the function that reduces blood fat and reduce blood lipid, and can reduce fat in endovascular deposition, and then play the effect of blood pressure lowering, prevention coronary heart disease; Fructus Fici also has the merit of anti-inflammation detumescence, can relieving sore throat and diminishing swelling.
Above-mentioned composition can be used as treatment cough, asthma, throat swell and ache, the have a stuffy nose prescription of the diseases such as disease such as low voice speaking, for clothes for patients; Be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make liquid dosage form product or solid dosage forms product, as: any dosage form on the pharmaceuticss such as oral liquid, capsule, tablet, granule, especially granule effect is better.
A kind of preparation method for the treatment of the Chinese medicine preparation of cough of the present invention, comprises the following steps:
1. take Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici 12 taste Chinese herbal medicine, standby;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the another device of the aqueous solution after distillation and medicinal residues is collected, standby;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and Fructus Fici Six-element medicine mix, soak 1.5 ~ 2 hours, decoct three times, add for the first time 15 ~ 20 times of water gagings, decoct 2 ~ 6 hours, add for the second time 6 ~ 15 times of water gagings, decoct 1 ~ 4 hour, add for the third time 3 ~ 8 times of water gagings, add 5 ~ 10 parts, crystal sugar, decoct 1 ~ 2 hour, merging filtrate, the aqueous solution that 2. filtrate that filter pressing obtains and above-mentioned steps collect merges, be concentrated into relative density and be the extractum of 1. 07 ~ 1. 12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, reconcentration to relative density is the thick paste of 1. 35 ~ 1. 38/80 ℃,
4. adjuvant 0. 1 ~ 0. 6 part that take 3 ~ 6 parts of thick pastes, meet medicinal standard mix, and with ethanol, as wetting agent, make wet granular, dry, let cool, and spray adds the volatile oil that 2. step is extracted, and mixes, and obtains product.
Preferably, a kind of preparation method for the treatment of the Chinese medicine preparation of cough, is characterized in that:
1. take Herba Ephedrae 200 g, the Radix Stemonae 180 g, Fructus Viticis Negundo 220 g, Herba Gnaphalii Affinis 150 g, Radix Eriobotryae dry powder 250 g, Calculus Bovis 300 g, Rhizoma Polygonati Odorati 260 g, Fructus Momordicae 580 g, Radix Puerariae 340 g, Herba monochasmatis 220 g, Fructus Fici Pumilae 170 g and Fructus Fici 130 g 12 taste Chinese herbal medicine, standby;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the another device of the aqueous solution after distillation and medicinal residues is collected, standby;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and Fructus Fici Six-element medicine mix, soak 1.5 hours, decoct three times, add for the first time 15 times of water gagings, decoct 4 hours, add for the second time 10 times of water gagings, decoct 2 hours, add for the third time 4 times of water gagings, add crystal sugar 500g, decoct 1 hour, merging filtrate, the aqueous solution that 2. filtrate that filter pressing obtains and above-mentioned steps collect merges, be concentrated into relative density and be the extractum of 1. 07 ~ 1. 12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, reconcentration to relative density is the thick paste of 1. 35 ~ 1. 38/80 ℃,
4. 0.3 part of the adjuvant that take 5 parts of thick pastes, meets medicinal standard mixes, and with ethanol, as wetting agent, makes wet granular, dry, lets cool, and spray adds the volatile oil that 2. step is extracted, and mixes, and obtains product.
The described adjuvant that meets medicinal standard is one or more the mixture in dextrin, starch, lactose.
The medicine that the 12 taste Chinese herbal medicine such as Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici make by advanced preparation method as raw material is take in the present invention.The formation of medicine of the present invention, technique, simple, clear and definite, quality is convenient to control, and granulation agent can increase applicable crowd; This product taking convenience, rapid-action, in, cough due to slight affection of exogenous wind-cold, inhibited pulmonary QI, expectoration, fever with aversion to cold, has a headache lossless, limb aching pain is had a stuffy nose and is low voice speakingly waited disease to have reasonable therapeutic effect.This volumes of formulation is little, takes after mixing it with hot water, is applicable to the standing medication of family.
Usage and dosage: boiled water is taken after mixing it with water, a 15g, 3 times on the one.
The specific embodiment
Embodiment 1:
Get Herba Ephedrae 100g, Radix Stemonae 167g, Fructus Viticis Negundo 244g, Herba Gnaphalii Affinis 154g, Radix Eriobotryae dry powder 246g, Calculus Bovis 345g, Rhizoma Polygonati Odorati 256g, Fructus Momordicae 580g, Radix Puerariae 320g, Herba monochasmatis 240g, Fructus Fici Pumilae 160g and Fructus Fici 155g 12 tastes, soak 2 hours, decoct three times, add for the first time 15 times of amounts, decoct 6 hours, add for the second time 10 times of amounts, decoct 4 hours, add for the third time 6 times of water gagings, add crystal sugar 800g, decoct 1.5 hours, merging filtrate, filter, filtrate and above-mentioned aqueous solution merge, be concentrated into relative density and be the clear paste of 1. 07 ~ 1.12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, filter, it is the thick paste of 1.35 ~ 1.38/80 ℃ that filtrate is concentrated into relative density.With composition by weight, calculate: take thick paste 418g, dextrin 32g mixes, and with ethanol, as wetting agent, makes wet granular, dry, let cool, spray adds volatile oil, mixes, and makes 30 bags, obtains.
Embodiment 2:
Get Radix Stemonae 243g, Fructus Viticis Negundo 244g, Rhizoma Polygonati Odorati 343 g, Fructus Momordicae 451g, Radix Puerariae 350g and Fructus Fici Pumilae 255g and extract volatile oil, the another device of aqueous solution after distillation is collected, medicinal residues and all the other Herba Ephedrae 200g, Herba Gnaphalii Affinis 357g, Radix Eriobotryae dry powder 149g, artificial Calculus Bovis 235g, Herba monochasmatis 356g and Fructus Fici 345g Six-element, soak 1.5 hours, decoct three times, add for the first time 15 times of water gagings, decoct 4 hours, add for the second time 10 times of water gagings, decoct 2 hours, add for the third time 4 times of water gagings, add crystal sugar 500g, decoct 1 hour, merging filtrate, aqueous solution after the filtrate that filter pressing obtains and above-mentioned distillation merges, be concentrated into relative density and be the extractum of 1. 07 ~ 1. 12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, reconcentration to relative density is the thick paste of 1. 35 ~ 1. 38/80 ℃, with composition by weight, calculate: take thick paste 1410g, starch 90g mixes, and with ethanol, as wetting agent, makes wet granular, dry, let cool, spray adds volatile oil, mixes, and makes 100 bags, obtains.
Embodiment 3:
Get Radix Stemonae 350g, Fructus Viticis Negundo 150g, Rhizoma Polygonati Odorati 540 g, Fructus Momordicae 350g, Radix Puerariae 160g and Fructus Fici Pumilae 470g and extract volatile oil, the another device of aqueous solution after distillation is collected, medicinal residues and all the other Herba Ephedrae 250g, Herba Gnaphalii Affinis 260g, Radix Eriobotryae dry powder 380g, artificial Calculus Bovis 120g, Herba monochasmatis 240g and Fructus Fici 130g Six-element, soak 2 hours, decoct secondary, add for the first time 20 times of water gagings, decoct 6 hours, add for the second time 15 times of water gagings, add crystal sugar 1000g, decoct 4 hours, merging filtrate, the filtrate that filter pressing obtains merges with the aqueous solution that distillation obtains, be concentrated into relative density and be the extractum of 1. 07 ~ 1. 12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, reconcentration to relative density is the thick paste of 1. 35 ~ 1. 38/80 ℃, with composition by weight, calculate: take thick paste 2750g, lactose 250g mixes, and with ethanol, as wetting agent, makes wet granular, dry, let cool, spray adds volatile oil, mixes, and makes 200 bags, obtains.
Toxicology test research of the present invention:
Studies on acute toxicity result: Chinese medicine preparation of the present invention is to mouse stomach 200g crude drug/kg/ day, is equivalent to draft 250 times of clinical Coming-of-Age Day dosage (0.8g crude drug/kg), has no dead mouse.Therefore can think that clinical to draft the every daily dose of adult be safe.
Long term toxicity result of study: 40 of rats, be divided at random 4 groups, i.e. blank group and three daily doses (0 crude drug/kg, 20g crude drug/kg, 40g crude drug/kg and 60g crude drug/kg) group, each dosage is 25 times, 50 times, 75 times of the every consumption per days of adult.Give continuously rat oral gavage 3 months, drug withdrawal 2 weeks.Experimental result: during each organizes rat administration and the behavior of drug withdrawal during 2 weeks, activity, spirit, fur, defecation without abnormal response, each organizes rat body weight, food-intake all increases day by day, with matched group no significant difference p>0.05 relatively; Hematological examination, blood biochemical are learned and are checked and internal organs pathological examination, no significant difference difference between administration group and matched group.Therefore, can think that product of the present invention is safe by using the dosage of clinical plan use and the course for the treatment of.
Pharmacodynamic study result of the present invention:
By the present invention has been carried out to a series of animal experiment study, its result is as follows:
1. antitussive action experimental study: application strong aqua ammonia draws the method for coughing, mice ammonia is drawn to the impact test of coughing, the high, medium and low dosage of result proved invention product all draws and coughs certain antitussive action mice ammonia, can significantly extend cough latent period and reduce cough number of times.Application sulfur dioxide draws the method for coughing, and mice sulfur dioxide is drawn to the impact test of coughing, and the cough latent period of the high, medium and low dosage group of product of the present invention is all than blank group leader, property that there were significant differences, and visible the present invention draws and coughs certain antitussive action mice sulfur dioxide;
2. phlegm-dispelling functions experimental study: the application phenol red method of trachea and capillary glass-tube expectoration method are tested, the phenol red content of flushing liquor of the high, medium and low dosage group of result is all higher than blank group, confirmed that the high, medium and low dosage of this confirmation product of the present invention all can make phenol red output of mice trachea and Hair of Rat thin glass tube expectoration amount showed increased, shows that this product has obvious phlegm-dispelling functions;
3. antiinflammatory action experimental study: adopt mice caused by dimethylbenzene xylene ear to swell and test, with the comparison of normal saline group, aspirin matched group, product xylol of the present invention cause that mice two auricle weight differences obviously reduce, ear swelling is obviously alleviated, show that this product xylol causes acute inflammation and has obvious inhibitory action.
Clinical research result: the several hospital clinicals in Guangxi test feedback data, the cough during Chinese medicine preparation of the present invention is used for the treatment of, due to slight affection of exogenous wind-cold, inhibited pulmonary QI, coughs up phlegm, fever with aversion to cold, has a headache lossless, limb aching pain, the disease such as have a stuffy nose low voice speaking, has no untoward reaction.
According to Guangxi provincial hospital, use the present invention to treat feedback data after cough Chinese medicinal granular formulation, the boiled water Chinese medicinal granular formulation of the present invention treatment cold cough of taking after mixing it with water, one time one bag (15g), every day three times, within 5 days, be a course for the treatment of, treatment 56 examples, patient's cough, expectoration symptom obviously alleviate, total effective rate is 95%, has no untoward reaction.
Another Guangxi provincial hospital feedback data, boiled water is taken after mixing it with water in Chinese medicinal granular formulation treatment of the present invention, slightly affection of exogenous wind-cold, cough, cough up phlegm, one time one bag (15g), every day three times, treat 25 examples, patient's laryngopharynx swelling and pain significantly alleviates, and cough, expectoration symptom are obviously improved, and body temperature is normal, total effective rate is 92%, has no untoward reaction.
Nanning City Hospitals feedback data, oral Chinese medicine preparation treatment cough of the present invention, asthma, fever with aversion to cold, have a headache lossless, limb aching pain, the disease such as have a stuffy nose low voice speaking, one time one bag (30g), every twice-daily, treat 30 examples, patient's symptom is obviously improved, is alleviated, and total effective rate is 85%.Have no untoward reaction.
Concrete clinical case:
Case 1: Wei so-and-so, 3 years old, in December, 2012 was medical.Low grade fever, cough, nasal obstruction watery nasal discharge, has rale sound in larynx, and inappetence, once took and quiet antibiotic, and effect is not good enough.Have a medical check-up: 38.5 ℃ of body temperature, swallow red, red tongue, tongue is white.Auscultation of lung: two fullness of the lung cloth rhonchi.Dialectical is accumulation of phlegm-damp in the lung, strongly fragrant and generate heat.Take the present invention and treat cough Chinese medicinal granular formulation, day takes 3 times, each two bag 30g.After 2 days, examine, disease alleviates again, and within 5 days, accuses more.
Case 2: Zhang, female, Zhuang, 58 years old, retired worker.On February 6th, 2013 is medical in certain hospital outpatient, and tcm diagnosis is cough, and Western medicine diagnose is acute episode of chronic bronchitis, symptoms including cough (+++), cough up phlegm (+++), and asthma (++), looking into pulmonary has wheezing sound (+).38.9 ℃ of body temperature, x-ray shows that lung marking strengthens; Routine blood test: leukocyte 9.4 * 10/L, neutrophilic granulocyte O. 73.Take the present invention treat cough Chinese medicinal granular formulation after cough reduce, 2 days afterwards cough stop, amount of expectoration obviously reduces.Continue check cough (-) after 6 days with the party, cough up phlegm (-), asthma (-), wheezing sound (-), 36. 6 ℃ of body temperature, x-ray shows two lung no abnormality seens.
Case 3: thank certain, female, 10 years old, in March, 2013 was medical.In mother generation, tells: cough January is with slight asthma, low grade fever before 2 days.Oral Chinese patent medicine, Western medicine, effect is not good enough.Disease: cough, the yellow thickness of expectorant, tongue is white; 37.8 ℃ of body temperature, two pulmonary respiration sounds are thick, audible and moderate rale.X-ray shows: two lung marking increase rent, disorder.Take the present invention and treat cough Chinese medicinal granular formulation, day takes 3 times, each 1 bag.After 2 days, examine, cough obviously alleviates again, and without heating, amount of expectoration reduces, and tonsil diminishes, this prescription recovery from illness in 6 days for following the service.
Case 4: Wu so-and-so, man, 66 years old.On March 7th, 2013 is admitted to hospital.Be diagnosed as acute episode of chronic bronchitis.Symptoms including cough (+++), cough up phlegm (++), asthma (++), pulmonary's heavy breathing toot sound (++), 38.1 ℃ of body temperature, x-ray shows that two lung marking strengthen, the wild lung marking disorder in lower-left; Routine blood test: leukocyte 9.3 * 1O/L, neutrophilic granulocyte 0.78.Take the present invention and treat the cough disappearance of panting after Chinese medicinal granular formulation, cough weakens, and after 18 hours, amount of expectoration significantly reduces.Continue cough after 7 days with the party (-), cough up phlegm (-), asthma (+), wheezing sound (+), 36.6 ℃ of body temperature, x-ray checks two lung no abnormality seens; Routine blood test is normal.Of that month clinical cure on the 20th is left hospital.
Case 5: Chen, man, 38 years old, first visit on April 21 in 2013, before two days, throat is uncomfortable, and with cough, before one day, the pain increased for throat, and dry cough is had a headache lossless, and systemic pain is uncomfortable, slight aversion to cold.Health check-up body temperature reaches 38.6 ℃, and cough uncomfortable in chest increases the weight of, the pharyngeal obvious hyperemia of health check-up, pale tongue yellow fur, two lung audibles and dry wet mouthful rale; Routine blood test: numeration of leukocyte is abnormal, neutrophilic granulocyte 0.81%, x-ray microscopical examination showed: bronchitis.Give granular preparation of the present invention and take, every day 3 times, each 2 bags, advise the pungent product of its fasting raw food, after 3 days, cough, spit, and uncomfortable in chestly subtract greatly, and temperature recovery is normal, and following the service is with after 10 days, and disease is known and removed.
Claims (8)
1. treat a Chinese medicine preparation for cough, it is characterized in that comprising the Chinese medicine of following composition by weight: 0.5 ~ 4 part of 1 ~ 6 part, 0.5 ~ 4 part, Herba Ephedrae, 0.5 ~ 4 part of the Radix Stemonae, 0.5 ~ 4 part of Fructus Viticis Negundo, 0.5 ~ 4 part of Herba Gnaphalii Affinis, 0.5 ~ 4 part, Radix Eriobotryae dry powder, 0.5 ~ 4 part of Calculus Bovis, 1 ~ 6 part of Rhizoma Polygonati Odorati, 1 ~ 6 part of Fructus Momordicae, 0.5 ~ 4 part of Radix Puerariae, 0.5 ~ 4 part of Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici.
2. according to a kind of Chinese medicine preparation for the treatment of cough described in claim 1, it is characterized in that comprising the Chinese medicine of following composition by weight: 1.55 parts of 1 part, Herba Ephedrae, 1.67 parts of the Radixs Stemonae, 2.44 parts of Fructus Viticis Negundo, 1.54 parts of Herba Gnaphalii Affinis, 2.46 parts, Radix Eriobotryae dry powder, 3.45 parts of Calculus Boviss, 2.56 parts of Rhizoma Polygonati Odorati, 5.8 parts of Fructus Momordicaes, 3.2 parts of Radix Puerariaes, 2.4 parts of Herba monochasmatiss, 1.6 parts of Fructus Fici Pumilaes and Fructus Ficis.
3. according to a kind of Chinese medicine preparation for the treatment of cough described in claim 1, it is characterized in that comprising the Chinese medicine of following composition by weight: 3.45 parts of 2 parts, Herba Ephedrae, 2.43 parts of the Radixs Stemonae, 2.44 parts of Fructus Viticis Negundo, 3.57 parts of Herba Gnaphalii Affinis, 1.49 parts, Radix Eriobotryae dry powder, 2.35 parts of Calculus Boviss, 3.43 parts of Rhizoma Polygonati Odorati, 4.51 parts of Fructus Momordicaes, 3.5 parts of Radix Puerariaes, 3.56 parts of Herba monochasmatiss, 2.55 parts of Fructus Fici Pumilaes and Fructus Ficis.
4. according to a kind of Chinese medicine preparation for the treatment of cough described in claim 1, it is characterized in that comprising the Chinese medicine of following composition by weight: 1.3 parts of 2.5 parts, Herba Ephedrae, 3.5 parts of the Radixs Stemonae, 1.5 parts of Fructus Viticis Negundo, 2.6 parts of Herba Gnaphalii Affinis, 3.8 parts, Radix Eriobotryae dry powder, 1.2 parts of Calculus Boviss, 5.4 parts of Rhizoma Polygonati Odorati, 3.5 parts of Fructus Momordicaes, 1.6 parts of Radix Puerariaes, 2.4 parts of Herba monochasmatiss, 4.7 parts of Fructus Fici Pumilaes and Fructus Ficis.
5. according to a kind of preparation method for the treatment of the Chinese medicine preparation of cough described in claim 1, it is characterized in that:
1. take Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici 12 taste Chinese herbal medicine, standby;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the another device of the aqueous solution after distillation and medicinal residues is collected, standby;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and Fructus Fici Six-element medicine mix, soak 1.5 ~ 2 hours, decoct three times, add for the first time 15 ~ 20 times of water gagings, decoct 2 ~ 6 hours, add for the second time 6 ~ 15 times of water gagings, decoct 1 ~ 4 hour, add for the third time 3 ~ 8 times of water gagings, add 5 ~ 10 parts, crystal sugar, decoct 1 ~ 2 hour, merging filtrate, the aqueous solution that 2. filtrate that filter pressing obtains and above-mentioned steps collect merges, be concentrated into relative density and be the extractum of 1. 07 ~ 1. 12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, reconcentration to relative density is the thick paste of 1. 35 ~ 1. 38/80 ℃,
4. adjuvant 0. 1 ~ 0. 6 part that take 3 ~ 6 parts of thick pastes, meet medicinal standard mix, and with ethanol, as wetting agent, make wet granular, dry, let cool, and spray adds the volatile oil that 2. step is extracted, and mixes, and obtains product.
6. according to a kind of preparation method for the treatment of the Chinese medicine preparation of cough described in claim 1, it is characterized in that:
1. take Herba Ephedrae 200 g, the Radix Stemonae 180 g, Fructus Viticis Negundo 220 g, Herba Gnaphalii Affinis 150 g, Radix Eriobotryae dry powder 250 g, Calculus Bovis 300 g, Rhizoma Polygonati Odorati 260 g, Fructus Momordicae 580 g, Radix Puerariae 340 g, Herba monochasmatis 220 g, Fructus Fici Pumilae 170 g and Fructus Fici 130 g 12 taste Chinese herbal medicine, standby;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the another device of the aqueous solution after distillation and medicinal residues is collected, standby;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and Fructus Fici Six-element medicine mix, soak 1.5 hours, decoct three times, add for the first time 15 times of water gagings, decoct 4 hours, add for the second time 10 times of water gagings, decoct 2 hours, add for the third time 4 times of water gagings, add crystal sugar 500g, decoct 1 hour, merging filtrate, the aqueous solution that 2. filtrate that filter pressing obtains and above-mentioned steps collect merges, be concentrated into relative density and be the extractum of 1. 07 ~ 1. 12/80 ℃, adding ethanol makes to reach 70% containing alcohol amount, standing 24 hours, reconcentration to relative density is the thick paste of 1. 35 ~ 1. 38/80 ℃,
4. 0.3 part of the adjuvant that take 5.7 parts of thick pastes, meets medicinal standard mixes, and with ethanol, as wetting agent, makes wet granular, dry, lets cool, and spray adds the volatile oil that 2. step is extracted, and mixes, and obtains product.
7. according to a kind of preparation method for the treatment of the Chinese medicine preparation of cough described in claim 5 or 6, it is characterized in that the described adjuvant that meets medical standard is one or more the mixture in dextrin, starch and lactose.
8. according to a kind of Chinese medicine preparation for the treatment of cough described in claim l, it is characterized in that: may be made in all dosage forms, especially granule on pharmaceutics.
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| CN104324345A (en) * | 2014-10-08 | 2015-02-04 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine composition with effect of cough treating, and preparation method thereof |
| CN105535156A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating coughs and preparation method and application thereof |
| CN106038577A (en) * | 2016-05-25 | 2016-10-26 | 暨南大学 | Medicine composition with cough relieving effect, and preparation method and application thereof |
| CN106070792A (en) * | 2016-06-15 | 2016-11-09 | 夏石生 | One wets one's whistle Antitussive health tea and preparation method thereof |
| CN109453298A (en) * | 2018-12-14 | 2019-03-12 | 湖北荆江源制药股份有限公司 | A kind of Chinese materia medica preparation for treating cough |
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| CN101385848A (en) * | 2008-10-20 | 2009-03-18 | 吴伶 | Medicine for treating bronchitis |
| CN101474373A (en) * | 2009-01-19 | 2009-07-08 | 河南百年康鑫药业有限公司 | Chinese medicine for treating acute pharyngitis |
| CN102204767A (en) * | 2011-05-05 | 2011-10-05 | 惠州市欧野科技有限公司 | Medicinal pillow for preventing and treating rhinitis |
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2013
- 2013-12-13 CN CN201310677075.9A patent/CN103656410B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385848A (en) * | 2008-10-20 | 2009-03-18 | 吴伶 | Medicine for treating bronchitis |
| CN101474373A (en) * | 2009-01-19 | 2009-07-08 | 河南百年康鑫药业有限公司 | Chinese medicine for treating acute pharyngitis |
| CN102204767A (en) * | 2011-05-05 | 2011-10-05 | 惠州市欧野科技有限公司 | Medicinal pillow for preventing and treating rhinitis |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324345A (en) * | 2014-10-08 | 2015-02-04 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine composition with effect of cough treating, and preparation method thereof |
| CN105535156A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating coughs and preparation method and application thereof |
| CN106038577A (en) * | 2016-05-25 | 2016-10-26 | 暨南大学 | Medicine composition with cough relieving effect, and preparation method and application thereof |
| CN106038577B (en) * | 2016-05-25 | 2018-12-14 | 暨南大学 | A kind of pharmaceutical composition and its preparation method and application with antitussive effect |
| CN106070792A (en) * | 2016-06-15 | 2016-11-09 | 夏石生 | One wets one's whistle Antitussive health tea and preparation method thereof |
| CN109453298A (en) * | 2018-12-14 | 2019-03-12 | 湖北荆江源制药股份有限公司 | A kind of Chinese materia medica preparation for treating cough |
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| CN103656410B (en) | 2016-01-13 |
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