CN103656410B - A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof Download PDFInfo
- Publication number
- CN103656410B CN103656410B CN201310677075.9A CN201310677075A CN103656410B CN 103656410 B CN103656410 B CN 103656410B CN 201310677075 A CN201310677075 A CN 201310677075A CN 103656410 B CN103656410 B CN 103656410B
- Authority
- CN
- China
- Prior art keywords
- parts
- fructus
- herba
- radix
- cough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Chinese medicine preparation for the treatment of cough and preparation method thereof; it is made up of 12 taste Chinese herbal medicine such as Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Ficis; by medicine thick paste, dextrin mixing; wet granular is made as wetting agent with ethanol; drying, lets cool, and spray adds volatile oil; mixing, obtains.This preparation centering, slight affection of exogenous wind-cold, cough caused by Lung Qi obstruction, cough up phlegm, fever with aversion to cold, has a headache lossless, limb aching pain, has a stuffy nose low voice speakingly to wait disease to have good curative effect.Compared with other Technology, formation, the technique of medicine of the present invention are simple, clear and definite, and quality is easy to control.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, especially a kind of Chinese medicine preparation for the treatment of cough and preparation method thereof.
Background technology
Cough is the protectiveness respiratory reflex action that human body removes secretions in respiratory tract or foreign body.But violent cough can cause respiratory tract hemorrhage, as a long time, frequently, violent cough affects work, has a rest, even causes laryngalgia, and hoarseness and breathing myalgia are the cardinal symptoms of respiratory system disease.The common disease of cough is caused to have upper respiratory tract infection, acute pharyngolaryngitis, bronchitis, pneumonia etc.Due to urban air environment worse and worse, clinical onset rate has the trend constantly risen in recent years.
The Chinese patent medicine that at present treatment cough is clinically conventional has a lot, in treatment, slight affection of exogenous wind-cold, cough caused by inhibited pulmonary QI, cough up phlegm, fever with aversion to cold, has a headache lossless, limb aching pain and nasal obstruction is low voice speaking etc. that disease commonly uses affection of exogenous wind-cold granule, affection of exogenous wind-cold ball etc.Said medicine differs from one another, and all has certain effect, but often falls flat.The present invention is based on the theoretical method of Chinese traditional treatment cough, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical tune, emergency is taken in concurrently, filter out clearing away lung-heat to relieve cough, natural vegetable Chinese herbal medicine that cold expelling reduces phlegm, be prepared from according to certain weight proportion, a kind of Chinese medicine preparation of evident in efficacy, with low cost, treatment cough that toxic and side effects is minimum be provided.
Summary of the invention
The object of this invention is to provide after the 12 taste Chinese herbal medicine extracting such as Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici are gone out effective ingredient by one and be made into Chinese medicine preparation; for in, cough caused by slight affection of exogenous wind-cold, inhibited pulmonary QI; cough up phlegm; fever with aversion to cold; have a headache lossless; limb aching pain, low voice speaking disease such as grade of having a stuffy nose has reasonable therapeutic effect.
The technical solution used in the present invention is:
Treat a Chinese medicine preparation for cough, comprise the Chinese medicine of following composition by weight: 0.5 ~ 4 part, Herba Ephedrae, the Radix Stemonae 0.5 ~ 4 part, Fructus Viticis Negundo 0.5 ~ 4 part, Herba Gnaphalii Affinis 0.5 ~ 4 part, 0.5 ~ 4 part, Radix Eriobotryae dry powder, Calculus Bovis 0.5 ~ 4 part, Rhizoma Polygonati Odorati 1 ~ 6 part, Fructus Momordicae 1 ~ 6 part, Radix Puerariae 0.5 ~ 4 part, Herba monochasmatis 0.5 ~ 4 part, Fructus Fici Pumilae 1 ~ 6 part and Fructus Fici 0.5 ~ 4 part.
Preferably; described a kind of Chinese medicine preparation for the treatment of cough, comprises the Chinese medicine of following composition by weight: 1 part, Herba Ephedrae, the Radix Stemonae 1.67 parts, Fructus Viticis Negundo 2.44 parts, Herba Gnaphalii Affinis 1.54 parts, 2.46 parts, Radix Eriobotryae dry powder, Calculus Bovis 3.45 parts, Rhizoma Polygonati Odorati 2.56 parts, Fructus Momordicae 5.8 parts, Radix Puerariae 3.2 parts, Herba monochasmatis 2.4 parts, Fructus Fici Pumilae 1.6 parts and Fructus Fici 1.55 parts.
Preferably; described a kind of Chinese medicine preparation for the treatment of cough, comprises the Chinese medicine of following composition by weight: 2 parts, Herba Ephedrae, the Radix Stemonae 2.43 parts, Fructus Viticis Negundo 2.44 parts, Herba Gnaphalii Affinis 3.57 parts, 1.49 parts, Radix Eriobotryae dry powder, Calculus Bovis 2.35 parts, Rhizoma Polygonati Odorati 3.43 parts, Fructus Momordicae 4.51 parts, Radix Puerariae 3.5 parts, Herba monochasmatis 3.56 parts, Fructus Fici Pumilae 2.55 parts and Fructus Fici 3.45 parts.
Preferably; described a kind of Chinese medicine preparation for the treatment of cough, comprises the Chinese medicine of following composition by weight: 2.5 parts, Herba Ephedrae, the Radix Stemonae 3.5 parts, Fructus Viticis Negundo 1.5 parts, Herba Gnaphalii Affinis 2.6 parts, 3.8 parts, Radix Eriobotryae dry powder, Calculus Bovis 1.2 parts, Rhizoma Polygonati Odorati 5.4 parts, Fructus Momordicae 3.5 parts, Radix Puerariae 1.6 parts, Herba monochasmatis 2.4 parts, Fructus Fici Pumilae 4.7 parts and Fructus Fici 1.3 parts.
According to Chinese medicine and modern pharmacology toxicity reported in literature, effect of each component of Chinese medicine preparation of the present invention and the effect in prescription thereof are described below:
Herba Ephedrae
ephedrasinicaStapf, be Ephedraceae, Ephedra is important medicinal plants, and alkaloid enriches, and energy diaphoresis cold expelling, depressed lung-energy dispersing, is applicable to wind and cold sense stomach, cough, asthma.
The Radix Stemonae
stemonasessilifolia (Miq.) Miq, another name: Herba delphinii grandiflori, Angiospermae is Stemonaceae plant Radix Stemonae.Radix Stemonae nature and flavor are sweet, bitter, and tepor returns lung meridian, cure mainly nourishing the lung to keep the adverse QI downward cough-relieving, cough for new chronic cough, pulmonary tuberculosis cough, pertussis.
Fructus Viticis Negundo
vitexnegundoL.,another name cloth Fructus Vitics Simplicifoliae, gold, Folium vilicis Negundo, Radix Hydrangeae Strigosae, five-leaved chaste tree bar, derive from the fruit of Verbenaceae five-leaved chaste tree, and energy relieving cough and asthma, loosening bowel to relieve constipation, is applicable to cough, expectoration, constipation.
Herba Gnaphalii Affinis
herbaGnaphaiiAffinis,feverfew.Gather when blooming, dry, remove most impurity, the dry place of storage.Cure mainly and eliminate the phlegm, cough, relievings asthma, wind-damp dispelling.
Radix Eriobotryae dry powder, for Folium Eriobotryae (
eriobotryajaponica (Thunb.) Lindl.) seed, Radix Eriobotryae selenium is done, smash to pieces and make powder, has preventing phlegm from forming and stopping coughing, effect of depressed liver-energy dispersing and QI regulating.
Calculus Bovis
calculusbovis, be the cholelithiasis of bovid cattle drying.Chinese medicine thinks Calculus Bovis gas delicate fragrance, and mildly bitter flavor is then sweet, cool in nature.Can be used for removing toxic substances, control laryngopharynx swelling and pain, eliminating pathogen from the lung for relieving asthma and cough with asthma.Because natural Calculus Bovis is very precious, artificial Calculus Bovis can be used.
Rhizoma Polygonati Odorati
polygonatumodoratum (Mill.), be Liliaceae herbaceos perennial.The rhizome of plant can hyoscine, and Chinese medicine name is also Rhizoma Polygonati Odorati, and autumn excavates, and cleans, shines to softness, repeatedly rub, and dry in the sun, to without hard-core, is dried, or steams thoroughly, rubs to translucent, dries, and cuts sheet or section use.Can control deficiency of YIN fire scorching, hemoptysis, cough, dry pharynx expectorant is tied, the diseases such as aphonia.
Fructus Momordicae
corsvenorMomordicaFruit, be the distinctive cucurbitaceous plant of China, sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, and effect of promoting the production of body fluid to quench thirst is applicable to lung-heat or xeropulmonary cough, pertussis and summer-heat impairment of body fluid thirsty etc., also have effect of loosening bowel to relieve constipation in addition.Energy anti-inflammation, is applicable to various infection.
Radix Puerariae
lobedKudzuvineRoot, be the tuber of liana Herba Gelsemii Elegantis, be that the one of some provinces and regions of southern china often eats vegetable, its sweet in the mouth is cool good to eat, can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, and Clinical practice Radix Puerariae treats flu and upper respiratory tract infection, cough, expectoration.
Herba monochasmatis
antlerpilosegrass, be the dry herb of goatweed Herba monochasmatis, energy nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription, is applicable to cough and asthma, laryngopharynx swelling and pain.
Fructus Fici Pumilae
manglietiafordiana (Hemsl.) OliV., be Magnoliaceae Manglietia plant, have another name called gold zone tree.Fructus Fici Pumilae stem branch can be controlled as medical material, cures mainly that excess-fire is just closed, punish-old people dry cough.
Fructus Fici
ficuscaricaLinn, belong to Moraceae Ficus, Fructus Fici sweet in the mouth, property is put down, nontoxic, has spleen invigorating, nourishes, effect of intestine moistening.Lipase contained by Fructus Fici, hydrolytic enzyme etc. have the function reducing blood fat Sum decomposition blood fat, can reduce fat in endovascular deposition, and then play the effect of blood pressure lowering, prevention coronary heart disease; Fructus Fici also has the merit of anti-inflammation detumescence, can relieving sore throat and diminishing swelling.
Above-mentioned composition can as treatment cough, asthma, throat swells and ache, the prescription of the diseases such as disease such as low voice speaking of having a stuffy nose, for clothes for patients; Be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make liquid dosage form product or solid dosage forms product, as: any dosage form on the pharmaceuticss such as oral liquid, capsule, tablet, granule, especially granule effect is better.
A kind of preparation method for the treatment of the Chinese medicine preparation of cough of the present invention, comprises the following steps:
1. Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici 12 taste Chinese herbal medicine is taken, for subsequent use;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the aqueous solution after distillation and the another device of medicinal residues are collected, for subsequent use;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and the mixing of Fructus Fici Six-element medicine, soak 1.5 ~ 2 hours, decoct three times, first time adds 15 ~ 20 times of water gagings, decoct 2 ~ 6 hours, second time adds 6 ~ 15 times of water gagings, decoct 1 ~ 4 hour, third time adds 3 ~ 8 times of water gagings, add 5 ~ 10 parts, crystal sugar, decoct 1 ~ 2 hour, merging filtrate, the filtrate that filter pressing obtains and the aqueous solution that 2. above-mentioned steps collects merge, be concentrated into the extractum that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, leave standstill 24 hours, reconcentration to relative density is the thick paste of 1.35 ~ 1.38/80 DEG C,
4. take thick paste 3 ~ 6 parts, meet adjuvant 0.1 ~ 0.6 part mixing of medicinal standard, make wet granular with ethanol as wetting agent, dry, let cool, spray adds the volatile oil that 2. step is extracted, and mixing, obtains product.
Preferably, a kind of preparation method for the treatment of the Chinese medicine preparation of cough, is characterized in that:
1. Herba Ephedrae 200g, Radix Stemonae 180g, Fructus Viticis Negundo 220g, Herba Gnaphalii Affinis 150g, Radix Eriobotryae dry powder 250g, Calculus Bovis 300g, Rhizoma Polygonati Odorati 260g, Fructus Momordicae 580g, Radix Puerariae 340g, Herba monochasmatis 220g, Fructus Fici Pumilae 170g and Fructus Fici 130g 12 taste Chinese herbal medicine is taken, for subsequent use;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the aqueous solution after distillation and the another device of medicinal residues are collected, for subsequent use;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and the mixing of Fructus Fici Six-element medicine, soak 1.5 hours, decoct three times, first time adds 15 times of water gagings, decoct 4 hours, second time adds 10 times of water gagings, decoct 2 hours, third time adds 4 times of water gagings, add crystal sugar 500g, decoct 1 hour, merging filtrate, the filtrate that filter pressing obtains and the aqueous solution that 2. above-mentioned steps collects merge, be concentrated into the extractum that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, leave standstill 24 hours, reconcentration to relative density is the thick paste of 1.35 ~ 1.38/80 DEG C,
4. take thick paste 5 parts, meet the adjuvant 0.3 part mixing of medicinal standard, make wet granular with ethanol as wetting agent, dry, let cool, spray adds the volatile oil that 2. step is extracted, and mixing, obtains product.
The described adjuvant meeting medicinal standard is the mixture of one or more in dextrin, starch, lactose.
The present invention is the medicine made by the preparation method of advanced person for raw material with 12 taste Chinese herbal medicine such as Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Ficis.The formation of medicine of the present invention, technique, simple, clear and definite, quality is convenient to control, and making granule can increase applicable crowd; This product taking convenience, rapid-action, in, cough caused by slight affection of exogenous wind-cold, inhibited pulmonary QI, expectoration, fever with aversion to cold, has a headache lossless, limb aching pain, has a stuffy nose low voice speakingly to wait disease to have reasonable therapeutic effect.This volumes of formulation is little, takes after mixing it with hot water, is applicable to the standing medication of family.
Usage and dosage: boiled water is taken after mixing it with water, a 15g, 3 times on the one.
Detailed description of the invention
Embodiment 1:
Get Herba Ephedrae 100g, Radix Stemonae 167g, Fructus Viticis Negundo 244g, Herba Gnaphalii Affinis 154g, Radix Eriobotryae dry powder 246g, Calculus Bovis 345g, Rhizoma Polygonati Odorati 256g, Fructus Momordicae 580g, Radix Puerariae 320g, Herba monochasmatis 240g, Fructus Fici Pumilae 160g and Fructus Fici 155g 12 taste, soak 2 hours, decoct three times, first time adds 15 times amount, decoct 6 hours, second time adds 10 times amount, decoct 4 hours, third time adds 6 times of water gagings, add crystal sugar 800g, decoct 1.5 hours, merging filtrate, filter, filtrate and above-mentioned aqueous solution merge, be concentrated into the clear paste that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, leave standstill 24 hours, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.38/80 DEG C.Calculate with composition by weight: take thick paste 418g, dextrin 32g and mix, make wet granular with ethanol as wetting agent, dry, let cool, spray adds volatile oil, and mixing, makes 30 bags, to obtain final product.
Embodiment 2:
Get Radix Stemonae 243g, Fructus Viticis Negundo 244g, Rhizoma Polygonati Odorati 343g, Fructus Momordicae 451g, Radix Puerariae 350g and Fructus Fici Pumilae 255g and extract volatile oil, the another device of the aqueous solution after distillation is collected, medicinal residues and all the other Herba Ephedrae 200g, Herba Gnaphalii Affinis 357g, Radix Eriobotryae dry powder 149g, artificial Calculus Bovis 235g, Herba monochasmatis 356g and Fructus Fici 345g Six-element, soak 1.5 hours, decoct three times, first time adds 15 times of water gagings, decoct 4 hours, second time adds 10 times of water gagings, decoct 2 hours, third time adds 4 times of water gagings, add crystal sugar 500g, decoct 1 hour, merging filtrate, aqueous solution after the filtrate that filter pressing obtains and above-mentioned distillation merges, be concentrated into the extractum that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, leave standstill 24 hours, reconcentration to relative density is the thick paste of 1.35 ~ 1.38/80 DEG C, calculate with composition by weight: take thick paste 1410g, starch 90g and mix, make wet granular with ethanol as wetting agent, dry, let cool, spray adds volatile oil, and mixing, makes 100 bags, to obtain final product.
Embodiment 3:
Get Radix Stemonae 350g, Fructus Viticis Negundo 150g, Rhizoma Polygonati Odorati 540g, Fructus Momordicae 350g, Radix Puerariae 160g and Fructus Fici Pumilae 470g and extract volatile oil, the another device of the aqueous solution after distillation is collected; Medicinal residues and all the other Herba Ephedrae 250g, Herba Gnaphalii Affinis 260g, Radix Eriobotryae dry powder 380g, artificial Calculus Bovis 120g, Herba monochasmatis 240g and Fructus Fici 130g Six-element, soak 2 hours, decoct secondary, first time adds 20 times of water gagings, decoct 6 hours, second time adds 15 times of water gagings, add crystal sugar 1000g, decoct 4 hours, merging filtrate, the aqueous solution that the filtrate that filter pressing obtains obtains with distillation merges, be concentrated into the extractum that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, and leave standstill 24 hours, reconcentration to relative density is the thick paste of 1.35 ~ 1.38/80 DEG C; Calculate with composition by weight: take thick paste 2750g, lactose 250g and mix, make wet granular with ethanol as wetting agent, dry, let cool, spray adds volatile oil, and mixing, makes 200 bags, to obtain final product.
Toxicology test research of the present invention:
Studies on acute toxicity result: Chinese medicine preparation of the present invention, to mouse stomach 200g crude drug/kg/ day, is equivalent to 250 times that draft clinical dosage for adults (0.8g crude drug/kg), has no dead mouse.Therefore can think clinical draft adult every daily dose be safe.
Long term toxicity result of study: rat 40, is divided into 4 groups at random, i.e. blank group and three daily dose (0 crude drug/kg, 20g crude drug/kg, 40g crude drug/kg and 60g crude drug/kg) groups, each dosage for adult every consumption per day 25 times, 50 times, 75 times.Give rat oral gavage 3 months, drug withdrawal 2 weeks continuously.Experimental result: during the administration of each group rat and the behavior of drug withdrawal during 2 weeks, activity, spirit, fur, defecation reaction without exception, respectively organize rat body weight, food-intake increase all day by day, compare no significant difference p>0.05 with matched group; Hematological examination, blood biochemical analysis inspection and internal organs pathological examination, no significant difference difference between administration group and matched group.Therefore, can think that product of the present invention is safe by using the dosage of clinical plan and the course for the treatment of.
Pharmacodynamic study result of the present invention:
By to invention has been a series of animal experiment study, its result is as follows:
1. antitussive action experimental study: application strong aqua ammonia draws the method for coughing, mice ammonia is drawn to the impact test coughed, the high, medium and low dosage of result proved invention product all draws mice ammonia coughs certain antitussive action, significantly can extend cough latent period and reduce cough number of times.Application sulfur dioxide draws the method for coughing, and mice sulfur dioxide is drawn to the impact test coughed, the cough latent period of product of the present invention high, medium and low dosage group all than blank group leader, property that there were significant differences, visible the present invention draws mice sulfur dioxide and coughs certain antitussive action;
2. phlegm-dispelling functions experimental study: the application phenol red method of trachea and capillary glass-tube expectoration method are tested, the phenol red content of flushing liquor of result high, medium and low dosage group is all higher than blank group, confirm that the high, medium and low dosage of this confirmation product of the present invention all can make mice trachea phenol red output and Hair of Rat thin glass tube expectoration amount showed increased, show that this product has obvious phlegm-dispelling functions;
3. antiinflammatory action experimental study: adopt mice caused by dimethylbenzene xylene ear to swell and test, compare with normal saline group, aspirin matched group, product xylol of the present invention cause mice two auricle weight difference obviously to reduce, ear swelling is obviously alleviated, shows that this product xylol causes acute inflammation and has obvious inhibitory action.
Clinical study results: the several hospital clinical in Guangxi test feedback data, during Chinese medicine preparation of the present invention is used for the treatment of, slight affection of exogenous wind-cold, cough caused by inhibited pulmonary QI, cough up phlegm, fever with aversion to cold, has a headache lossless, limb aching pain, the disease such as to have a stuffy nose low voice speaking, have no untoward reaction.
According to Guangxi provincial hospital use the present invention treat cough Chinese medicinal granular formulation after feedback data, boiled water take after mixing it with water Chinese medicinal granular formulation of the present invention treatment cold cough, one time one bag (15g), every day three times, within 5 days, be a course for the treatment of, treatment 56 example, patient's cough, expectoration symptom obviously alleviate, total effective rate is 95%, has no untoward reaction.
Another Guangxi provincial hospital feedback data, boiled water is taken after mixing it with water in Chinese medicinal granular formulation of the present invention treatment, slightly affection of exogenous wind-cold, cough, cough up phlegm, one time one bag (15g), every day three times, treatment 25 example, patient's laryngopharynx swelling and pain significantly alleviates, and cough, expectoration symptom obviously improve, and body temperature is normal, total effective rate is 92%, has no untoward reaction.
Nanning City Hospitals feedback data, oral Chinese medicine preparation treatment cough of the present invention, asthma, fever with aversion to cold, have a headache lossless, limb aching pain, the disease such as to have a stuffy nose low voice speaking, one time one bag (30g), every twice-daily, treat 30 examples, patients symptomatic obviously improves, alleviate, total effective rate is 85%.Have no untoward reaction.
Concrete clinical case:
Case 1: Wei so-and-so, 3 years old, in December, 2012 was gone to a doctor.Low grade fever, cough, nasal obstruction watery nasal discharge, has rale sound, inappetence, once takes and quiet antibiotic, less effective in larynx.Have a medical check-up: body temperature 38.5 DEG C, swallow red, red tongue, tongue is white.Auscultation of lung: two fullness of the lung cloth rhonchi.Dialectical is accumulation of phlegm-damp in the lung, strongly fragrant and generate heat.Take the present invention and treat cough Chinese medicinal granular formulation, take 3 day, each two bag 30g.Examine after 2 days, disease alleviates again, and within 5 days, accuses more.
Case 2: Zhang, female, Zhuang, 58 years old, retired worker.On February 6th, 2013 goes to a doctor in certain hospital outpatient, and tcm diagnosis is cough, and Western medicine diagnose is acute episode of chronic bronchitis, symptoms including cough (+++), cough up phlegm (+++), and asthma (++), looking into pulmonary has wheezing sound (+).Body temperature 38.9 DEG C, x-ray display lung marking strengthens; Routine blood test: leukocyte 9.4 × 10/L, neutrophilic granulocyte O.73.Take the present invention treat cough Chinese medicinal granular formulation after cough reduce, stopping of coughing after 2 days, amount of expectoration obviously reduces.Continue checking cough (-) with the party after 6 days, cough up phlegm (-), asthma (-), wheezing sound (-), body temperature 36.6 DEG C, the two lung no abnormality seen of x-ray display.
Case 3: thank certain, female, 10 years old, in March, 2013 went to a doctor.Mother generation tell: cough January with slight asthma, low grade fever before 2 days.Oral Chinese patent medicine, Western medicine, less effective.Disease: cough, the yellow thickness of expectorant, tongue is white; Body temperature 37.8 DEG C, two pulmonary respiration sounds are thick, audible and moderate rale.X-ray shows: two lung marking increase rent, disorder.Take the present invention and treat cough Chinese medicinal granular formulation, take 3 day, each 1 bag.Examine after 2 days, cough obviously alleviates again, and without heating, amount of expectoration reduces, and tonsil diminishes, following the service this prescription recovery from illness in 6 days.
Case 4: Wu so-and-so, man, 66 years old.On March 7th, 2013 is admitted to hospital.Be diagnosed as acute episode of chronic bronchitis.Symptoms including cough (+++), cough up phlegm (++), asthma (++), pulmonary's heavy breathing toot sound (++), body temperature 38.1 DEG C, the two lung marking of x-ray display strengthens, the wild lung marking disorder in lower-left; Routine blood test: leukocyte 9.3 × 1O/L, neutrophilic granulocyte 0.78.Take after the present invention treats cough Chinese medicinal granular formulation and to pant disappearance, cough weakens, and after 18 hours, amount of expectoration significantly reduces.Continue coughing (-) after 7 days with the party, cough up phlegm (-), asthma (+), wheezing sound (+), body temperature 36.6 DEG C, and x-ray checks two lung no abnormality seen; Routine blood test is normal.Of that month clinical cure on the 20th is left hospital.
Case 5: Chen, man, 38 years old, first visit on April 21 in 2013, before two days, throat was uncomfortable, and with cough, before one day, the pain increased for throat, dry cough, has a headache lossless, and systemic pain is uncomfortable, slight aversion to cold.Health check-up body temperature reaches 38.6 DEG C, and cough uncomfortable in chest increases the weight of, the pharyngeal obvious hyperemia of health check-up, pale tongue yellow fur, two lung audibles and dry wet mouth rale; Routine blood test: numeration of leukocyte is abnormal, neutrophilic granulocyte 0.81%, x-ray microscopical examination showed: bronchitis.Give granular preparation of the present invention to take, every day 3 times, each 2 bags, advise the product that its fasting raw food is pungent, cough, spit after 3 days, uncomfortable in chestly subtract greatly, and temperature recovery is normal, and following the service is with after 10 days, and disease is known and removed.
Claims (8)
1. treat a Chinese medicine preparation for cough, it is characterized in that the Chinese medicine comprising following composition by weight: 0.5 ~ 4 part, Herba Ephedrae, the Radix Stemonae 0.5 ~ 4 part, Fructus Viticis Negundo 0.5 ~ 4 part, Herba Gnaphalii Affinis 0.5 ~ 4 part, 0.5 ~ 4 part, Radix Eriobotryae dry powder, Calculus Bovis 0.5 ~ 4 part, Rhizoma Polygonati Odorati 1 ~ 6 part, Fructus Momordicae 1 ~ 6 part, Radix Puerariae 0.5 ~ 4 part, Herba monochasmatis 0.5 ~ 4 part, Fructus Fici Pumilae 1 ~ 6 part and Fructus Fici 0.5 ~ 4 part.
2. a kind of Chinese medicine preparation for the treatment of cough according to claim 1, is characterized in that the Chinese medicine comprising following composition by weight: 1 part, Herba Ephedrae, the Radix Stemonae 1.67 parts, Fructus Viticis Negundo 2.44 parts, Herba Gnaphalii Affinis 1.54 parts, 2.46 parts, Radix Eriobotryae dry powder, Calculus Bovis 3.45 parts, Rhizoma Polygonati Odorati 2.56 parts, Fructus Momordicae 5.8 parts, Radix Puerariae 3.2 parts, Herba monochasmatis 2.4 parts, Fructus Fici Pumilae 1.6 parts and Fructus Fici 1.55 parts.
3. a kind of Chinese medicine preparation for the treatment of cough according to claim 1, is characterized in that the Chinese medicine comprising following composition by weight: 2 parts, Herba Ephedrae, the Radix Stemonae 2.43 parts, Fructus Viticis Negundo 2.44 parts, Herba Gnaphalii Affinis 3.57 parts, 1.49 parts, Radix Eriobotryae dry powder, Calculus Bovis 2.35 parts, Rhizoma Polygonati Odorati 3.43 parts, Fructus Momordicae 4.51 parts, Radix Puerariae 3.5 parts, Herba monochasmatis 3.56 parts, Fructus Fici Pumilae 2.55 parts and Fructus Fici 3.45 parts.
4. a kind of Chinese medicine preparation for the treatment of cough according to claim 1, is characterized in that the Chinese medicine comprising following composition by weight: 2.5 parts, Herba Ephedrae, the Radix Stemonae 3.5 parts, Fructus Viticis Negundo 1.5 parts, Herba Gnaphalii Affinis 2.6 parts, 3.8 parts, Radix Eriobotryae dry powder, Calculus Bovis 1.2 parts, Rhizoma Polygonati Odorati 5.4 parts, Fructus Momordicae 3.5 parts, Radix Puerariae 1.6 parts, Herba monochasmatis 2.4 parts, Fructus Fici Pumilae 4.7 parts and Fructus Fici 1.3 parts.
5. a kind of preparation method for the treatment of the Chinese medicine preparation of cough according to claim 1, is characterized in that:
1. Herba Ephedrae, the Radix Stemonae, Fructus Viticis Negundo, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae, Herba monochasmatis, Fructus Fici Pumilae and Fructus Fici 12 taste Chinese herbal medicine is taken, for subsequent use;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the aqueous solution after distillation and the another device of medicinal residues are collected, for subsequent use;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and the mixing of Fructus Fici Six-element medicine, soak 1.5 ~ 2 hours, decoct three times, first time adds 15 ~ 20 times of water gagings, decoct 2 ~ 6 hours, second time adds 6 ~ 15 times of water gagings, decoct 1 ~ 4 hour, third time adds 3 ~ 8 times of water gagings, add 5 ~ 10 parts, crystal sugar, decoct 1 ~ 2 hour, merging filtrate, the filtrate that filter pressing obtains and the aqueous solution that 2. above-mentioned steps collects merge, be concentrated into the extractum that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, leave standstill 24 hours, reconcentration to relative density is the thick paste of 1.35 ~ 1.38/80 DEG C,
4. take thick paste 3 ~ 6 parts, meet adjuvant 0.1 ~ 0.6 part mixing of medicinal standard, make wet granular with ethanol as wetting agent, dry, let cool, spray adds the volatile oil that 2. step is extracted, and mixing, obtains product.
6. a kind of preparation method for the treatment of the Chinese medicine preparation of cough according to claim 1, is characterized in that:
1. Herba Ephedrae 200g, Radix Stemonae 180g, Fructus Viticis Negundo 220g, Herba Gnaphalii Affinis 150g, Radix Eriobotryae dry powder 250g, Calculus Bovis 300g, Rhizoma Polygonati Odorati 260g, Fructus Momordicae 580g, Radix Puerariae 340g, Herba monochasmatis 220g, Fructus Fici Pumilae 170g and Fructus Fici 130g 12 taste Chinese herbal medicine is taken, for subsequent use;
2. get the Radix Stemonae, Fructus Viticis Negundo, Rhizoma Polygonati Odorati, Fructus Momordicae, Radix Puerariae and Fructus Fici Pumilae Six-element Chinese herbal medicine extracting volatile oil, the aqueous solution after distillation and the another device of medicinal residues are collected, for subsequent use;
3. get step 2. in distillation after medicinal residues and Herba Ephedrae, Herba Gnaphalii Affinis, Radix Eriobotryae dry powder, Calculus Bovis, Herba monochasmatis and the mixing of Fructus Fici Six-element medicine, soak 1.5 hours, decoct three times, first time adds 15 times of water gagings, decoct 4 hours, second time adds 10 times of water gagings, decoct 2 hours, third time adds 4 times of water gagings, add crystal sugar 500g, decoct 1 hour, merging filtrate, the filtrate that filter pressing obtains and the aqueous solution that 2. above-mentioned steps collects merge, be concentrated into the extractum that relative density is 1.07 ~ 1.12/80 DEG C, adding ethanol makes alcohol content reach 70%, leave standstill 24 hours, reconcentration to relative density is the thick paste of 1.35 ~ 1.38/80 DEG C,
4. take thick paste 5.7 parts, meet the adjuvant 0.3 part mixing of medicinal standard, make wet granular with ethanol as wetting agent, dry, let cool, spray adds the volatile oil that 2. step is extracted, and mixing, obtains product.
7. a kind of preparation method for the treatment of the Chinese medicine preparation of cough according to claim 5 or 6, is characterized in that the described adjuvant meeting medical standards is the mixture of one or more in dextrin, starch and lactose.
8. a kind of Chinese medicine preparation for the treatment of cough according to claim l, is characterized in that: this Chinese medicine preparation makes granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310677075.9A CN103656410B (en) | 2013-12-13 | 2013-12-13 | A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310677075.9A CN103656410B (en) | 2013-12-13 | 2013-12-13 | A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103656410A CN103656410A (en) | 2014-03-26 |
| CN103656410B true CN103656410B (en) | 2016-01-13 |
Family
ID=50295968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310677075.9A Active CN103656410B (en) | 2013-12-13 | 2013-12-13 | A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103656410B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324345A (en) * | 2014-10-08 | 2015-02-04 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine composition with effect of cough treating, and preparation method thereof |
| CN105535156A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating coughs and preparation method and application thereof |
| CN106038577B (en) * | 2016-05-25 | 2018-12-14 | 暨南大学 | A kind of pharmaceutical composition and its preparation method and application with antitussive effect |
| CN106070792A (en) * | 2016-06-15 | 2016-11-09 | 夏石生 | One wets one's whistle Antitussive health tea and preparation method thereof |
| CN109453298A (en) * | 2018-12-14 | 2019-03-12 | 湖北荆江源制药股份有限公司 | A kind of Chinese materia medica preparation for treating cough |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385848A (en) * | 2008-10-20 | 2009-03-18 | 吴伶 | Medicine for treating bronchitis |
| CN101474373A (en) * | 2009-01-19 | 2009-07-08 | 河南百年康鑫药业有限公司 | Chinese medicine for treating acute pharyngitis |
| CN102204767A (en) * | 2011-05-05 | 2011-10-05 | 惠州市欧野科技有限公司 | Medicinal pillow for preventing and treating rhinitis |
-
2013
- 2013-12-13 CN CN201310677075.9A patent/CN103656410B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385848A (en) * | 2008-10-20 | 2009-03-18 | 吴伶 | Medicine for treating bronchitis |
| CN101474373A (en) * | 2009-01-19 | 2009-07-08 | 河南百年康鑫药业有限公司 | Chinese medicine for treating acute pharyngitis |
| CN102204767A (en) * | 2011-05-05 | 2011-10-05 | 惠州市欧野科技有限公司 | Medicinal pillow for preventing and treating rhinitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103656410A (en) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103550729B (en) | A kind of Chinese medicine composition for the treatment of cough | |
| CN103656410B (en) | A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof | |
| CN101829293A (en) | Traditional Chinese medicine composite for treating cough disease and preparation method thereof | |
| CN106138360A (en) | A kind of Chinese medicine composition and preparation method thereof, application | |
| CN105902906A (en) | Traditional Chinese medicine composition for treating wind-cold-type cold and cough and preparation method thereof | |
| CN103719491B (en) | A kind of sealwort invigorating the spleen moistening lung health protection tea and preparation method thereof | |
| CN102961657B (en) | Chinese medicinal composition for treating cough | |
| CN105169212A (en) | Traditional Chinese medicine composition for treating chronic gastritis | |
| CN104758890A (en) | Traditional Chinese medicine composition for treating cough | |
| CN103961614B (en) | Chinese medicine composition for treating respiratory disease and its production and use | |
| CN103211970B (en) | Traditional Chinese medicine composition for treatment of wind-heat cough | |
| CN103989762B (en) | Chinese medicine composition of internal organs relieving cough and resolving phlegm and preparation method thereof is rushed down in a kind of heat clearing away | |
| CN103405722B (en) | Chinese herba preparation for preventing and treating infantile cough | |
| CN114712478A (en) | Traditional Chinese medicine composition and preparation for treating intestinal diseases and preparation method thereof | |
| CN106421335A (en) | Compound medicine for treating chronic pharyngitis | |
| CN102626511B (en) | Drug composition used for relieving cough and eliminating phlegm | |
| CN104258224A (en) | Schisandra chinensis oral solution for treating lung-and-kidney yin-deficiency type chronic bronchitis and preparation method thereof | |
| CN104474310A (en) | Traditional Chinese medicine composition for treating cough as well as preparation method and application of traditional Chinese medicine composition | |
| CN102772645B (en) | Traditional Chinese medicine for treating cold and preparation method thereof | |
| CN108143944A (en) | A kind of Chinese medicine composition for treating cold | |
| CN105327198A (en) | Heat-clearing and cough-relieving health care tea and preparation method and application thereof | |
| CN106421314A (en) | Traditional Chinese medicinal composition for treating viral respiratory infection and preparation method of traditional Chinese medicinal composition | |
| CN104258231A (en) | Traditional Chinese medicine composition for treating cough | |
| CN103768569B (en) | A kind of Chinese medicinal capsule for the treatment of chronic bronchitis | |
| CN107823424A (en) | A kind of Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |