CN106421314A

CN106421314A - Traditional Chinese medicinal composition for treating viral respiratory infection and preparation method of traditional Chinese medicinal composition

Info

Publication number: CN106421314A
Application number: CN201610278986.8A
Authority: CN
Inventors: 曲敬来; 高雪; 陈生; 齐继贵
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-04-29
Filing date: 2016-04-29
Publication date: 2017-02-22

Abstract

The invention discloses a traditional Chinese medicinal composition for treating viral respiratory infection and a preparation method of the traditional Chinese medicinal composition. The composition consists of the following medicinal raw materials in parts by weight: 5-20 parts of folium perillae, 1-15 parts of cortex magnoliae officinalis processed with ginger, 5-25 parts of schizonepeta spikes, 5-20 parts of radix asteris, 5-15 parts of apricot kernels, 5-20 parts of fried fructus perillae, 3-15 parts of rhizoma anemarrhenae, 3-15 parts of bulbus fritillariae thunbergii, 5-25 parts of fructus arctii and 2-15 parts of liquorice root. The medicinal raw materials, in coordination with adjuvants and a flavoring agent, are directly or indirectly prepared into pharmaceutically acceptable dosage forms such as capsules, oral liquid, granules, syrup, tablets, effervescent granules, dropping pills, an aerosol, a spray, gargarisma, mouthwash and the like by virtue of a conventional process. In the clinical field, the traditional Chinese medicinal composition can be used for preventing or treating respiratory virus infectious diseases caused by influenza A viruses, influenza B viruses, rhinoviruses, coronaviruses, respiratory syncytial viruses, hand, foot and mouth viruses, adenoviruses, parainfluenza viruses, echoviruses, Coxsackie viruses and the like.

Description

A kind of Chinese medicine composition treating viral respiratory infection and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicines, be a kind of with regard to Chinese traditional treatment respiratory viral infection disease, particularly Treat Chinese medicine composition based on following respiratory viral infection disease and preparation method thereof.Wherein, described respiratory diseases Poison infects and refers to influenza A virus, influenza B virus, rhinovirus, coronavirus, Respiratory Syncytial Virus(RSV), hand-foot-and-mouth disease The respiratory virus infection that poison, adenovirus, parainfluenza virus, echovirus, Coxsackie virus etc. are caused.

Background technology

Human respiratory tract is the door of an opening, and extraneous virus easily enters human body by respiratory tract, causes respiratory system Infecting, relevant investigation display, the ratio that the respiratory tract infection causing after virus attack human body occurs greatly exceeds bacterium sense The ratio of the respiratory infectious disease that dye human body causes.Virus has had stronger infectiousness mostly, and onset is hurried, passes Broadcast rapidly, it is easy to the progress of disease, there is higher morbidity risk rate and death rate.Respiratory tract infection includes the infection of the upper respiratory tract, tracheae Inflammation, bronchitis and Bronchopneumonia.The pathogen of ALRI is various virus and bacterium.Weak, allergy and slow Property nasosinusitis person is often susceptible to suffer from this disease, the especially more easy infection when climate change, air pollution environmental.During lower respiratory channel virus infection In addition to having upper respiratory tract infection symptoms, cough is many in dryness in early days, transfers moist cough in the later stage. and also have some patients companion to breathe heavily The symptoms such as ring, respiratory rhythm speed, appetite difference drowsiness, spiritual, the lower respiratory channel virus infection disease incidence of disease in recent years has The trend increasing, as shown according to etiologic research, viral pneumonia accounts for the 18% of community acquired pneumonia, in hospital's same period Interior Acquired Infection accounts for 5%, is especially infecting human immunodeficiency virus when cause（HIV）AIDS VICTIMS in, its The incidence of disease drastically raises especially, is more and more paid close attention to by people.Thus how can cure Respirovirus efficiently and effectively Infectious diseases is particularly important.

The common virus of respiratory tract infection has influenza A virus, influenza B virus, rhinovirus, coronavirus, breathing Road syncytial virus, hand-foot-and-mouth disease poison, adenovirus, parainfluenza virus, echovirus, Coxsackie virus etc..Acute viral laryngitis How to be caused by influenza A virus, influenza B virus, rhinovirus, parainfluenza virus and adenovirus etc., Clinical symptoms be trachyphonia, Pain when difficulty speaking, cough, often has heating, pharyngitis or cough, and health check-up shows laryngeal edema, hyperemia, and regional nodes is slight Enlargement and tenderness, audible and whoop；Acute viral bronchitis is how sick by rhinovirus, influenza A virus, influenza B Poison, parainfluenza virus, Respiratory Syncytial Virus(RSV), adenovirus etc. cause, and clinical manifestation is cough, is mucus without phlegm or phlegm, companion Have and generate heat and weak, uncomfortable in chest.Other symptoms often have pain, audible and dryness or moist sound, X under trachyphonia, non-pleura breastbone Line chest films showed blood vessel shade increases, strengthens, but apneumia infiltration shade；Influenza A virus, influenza B virus or rhinovirus Property bronchitis often causes the acute attack of chronic bronchitis；Viral bronchiolitis is mainly drawn by Respiratory Syncytial Virus(RSV) Rising, typically occurring in infant, performance cough, asthma, severe patient may occur in which cyanosis；Viral pneumonia is mainly sick by Flu-A Poison, influenza B virus, rhinovirus, parainfluenza virus, adenovirus and Respiratory Syncytial Virus(RSV) etc. cause.Performance heating, cough, The circulation of vital energy in the wrong direction, shortness of breath, flaring nares, severe one may occur in which that lip and nail are livid purple, and Chest X-rays shows pulmonary shadow.

Because virus utilizes the metabolic pathway of host cell to replicate, so, in general, can be right if do not used The medicine that host cell produces toxic action is difficult to be eliminated.At present, domestic and international doctor trained in Western medicine is to the virus such as rhinovirus, coronavirus Infect many employing Ribavirins to treat.Owing to rhinovirus serotype is many, and viral antigen constantly makes a variation, for each blood Clear type all works out corresponding vaccine to prevent this target of rhinovirus infection to be difficult to.To influenza A virus, second The prevention and controls of type influenza virus is exactly the generation using the pre-anti-virus of vaccine according to antigen-antibody theory, but due to viral Antigen constantly occurs to make a variation, and vaccine often also just loses effect.And be used for antiviral drug, based on viral variability and Problems such as the resistance of medicine, and antibiotic is invalid to virus, make virus to prevent and treat problem still very severe.

Respiratory viral infection disease belongs to " flu ", " cough ", " dyspnea " of the traditional Chinese medical science, among " roar disease ", this disease Generation many, six external factors which cause diseases inappropriate at weather cataclysm, changes in temperature when evil vigorous when, or human righteousness's virtual loss, easily by outer evil when.As 《Plain Questions comments pyretography》Say：" being gathered of heresy, its gas must be empty ".If daily life is lacked of proper care, cold temperature is uncomfortable, or overstrain, all The human body flesh natural fibre line of meat can be made to loosen, and disharmony between ying and wei, healthy tendency virtual loss, weakened defensive QI, being invaded by exogenous pathogen,invasion of exogenous pathogen i.e. susceptible disease theory of traditional Chinese medical science thinks " lung Main gas, department breathes "." gas " mentioned here, on the one hand refers to the gas of breathing, on the one hand refers to that lung and other internal organs show and exhales Function in terms of suction." lung opening at nose and throat, outer conjunction fur ".《Plain Questions. cough opinion》Say：" fur person, the conjunction of lung also, fur First by perverse trend, perverse trend is to close also from it ", say is that lung is communicated with the external world by pharynx nasalis and skin hair key, just as one barrier, The defensive enginery of supervisor's human body.External wind, cold, heat, wet, dry, fiery（It is referred to as the heresy of the six external factors which cause diseases）Etc. paathogenic factor often through Pharynx nasalis and fur, first invade in lung, causes lung qi to lose and sends out or during respectful fall in a surname, all can make Lung Qi upward reversal and cause cough, Pant, the symptom such as expectoration, this belongs to exogenous cough.The heresy of the six external factors which cause diseases cause a disease, how with ailment said due to cold or exposure based on, winter many chill, spring many wind-heat, Xia Duo Summer-heat and damp, autumn many wind-dryness, plum rain season holds damp evil under the arm more.Rather than when gas when holding under the arm row virus hurt sb.'s feelings, then be often not limited to season, and The state of an illness is multiple, easily causes infection popular.And influenza, belong to the wind-warm syndrome category of warm disease, belong to influenza, its feature also positive capsule Include the feature of diseases caused by external factors respiratory disease：Seasonable, heating height, state of an illness weight, infection popularity is strong, scope is wide.

Chinese medicine not only has that drug resistance is low, side effect and the advantage such as bad reaction is few, and also has suppression virus replication, tune Save immunologic function, improve the comprehensive effect such as blood circulation, antipyretic-antalgic and anti-inflammation, some antipyretic and antidotal type medium-height grass therein In medical instrument plays the role of induction human body, interferon produces, such that it is able to suppression virus replication, the immunity of regulation human body, promotes lung The improvement of ventilatory function and microcirculatory improvement, can reach further to mitigate the state of an illness of patient, shorten the course of disease, the reduction death rate Purpose.It has advantage and the vast potential for future development of uniqueness in terms of preventing and treating virus infection.Research shows, antipyretic and antidotal type Chinese medicine plays the role of many and has directly antiviral, such as rhizome of cyrtomium, honeysuckle, mother chrysanthemum, folium isatidis etc..

Content of the invention

Therefore, the Chinese medicine preparation to curative effect more preferable treatment respiratory virus infection for the people still suffers from demand.Up to now, Also do not find any report about pharmaceutical composition of the present invention.The present inventor is through repeatedly studying, and by external and face The checking repeatedly of bed test, have found the Chinese medicine composition of the treatment respiratory virus infection of more preferable curative effect finally, thus complete Become the present invention.The present invention is directed to above-mentioned etiology and pathogenesis, use targetedly and there is unique treatment respiratory virus infection The prepared from traditional Chinese medicines of effect forms.Said composition mainly by perilla leaf, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, ching-chieh, aster, almond, roasted perilla fruit, know Mother, fritillaria thunbergii, great burdock achene, Radix Glycyrrhizae composition, there is wind and heat dispersing, relieving cough and asthma work(, can be clinically used for treatment or prevention by Influenza A virus, influenza B virus, rhinovirus, coronavirus, Respiratory Syncytial Virus(RSV), hand-foot-and-mouth disease poison, adenovirus, pair The respiratory viral infection disease that influenza virus, echovirus, Coxsackie virus etc. are caused.At the medicine that this patent is declared Side is owing to have employed monarch drug in a prescription perilla leaf so that this prescription is more suitable for high blood pressure, prostate, neurasthenia insomniac.This The addition of another monarch drug in a prescription stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice of the drug prescription that patent is declared so that this prescription is more suitable for outer heresy and attacks lung, impairment of purifying and descending function of the lung Cough.Positive so-called《The Treatise on Fevrile Diseases》" asthmatic, makees Guizhi decoction, thickeies Piao Xingzi good ".

It is an object of the invention to：Overcome the deficiencies in the prior art, provide one can effectively to treat or prevent by A type stream Influenza Virus, influenza B virus, rhinovirus, coronavirus, Respiratory Syncytial Virus(RSV), hand-foot-and-mouth disease poison, adenovirus, parainfluenza virus The Chinese medicine composition of the viral respiratory infection that poison, echovirus, Coxsackie virus etc. are caused.

It is another object of the present invention to：Provide the preparation method of this Chinese medicine composition, meet the demand in market.

For reaching more preferable curative effect, medicine of the present invention can combine with raw material radix bupleuri, the root of large-flowered skullcap.

For reaching more preferable curative effect, medicine of the present invention can combine with raw material Oroxylum indicum, Lasiosphaera fenzlii.

For reaching more preferable curative effect, medicine of the present invention can combine with the raw material root of kudzu vine, Bulbus Fritillariae Cirrhosae.

A kind of Chinese medicine composition treating viral respiratory infection, including the bulk drug of following parts by weight：Perilla leaf 5-20 part, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-15 part, ching-chieh 5-25 part, aster 5-20 part, almond 5-15 part, roasted perilla fruit 5-20 part, wind-weed 3- 15 parts, fritillaria thunbergii 3-15 part, great burdock achene 5-25 part, Radix Glycyrrhizae 2-15 part.

Wherein the consumption of bulk drug can also is that：Perilla leaf 5-15 part, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-10 part, ching-chieh 5-15 part, aster 5-15 part, almond 5-10 part, roasted perilla fruit 5-10 part, wind-weed 3-10 part, fritillaria thunbergii 3-10 part, great burdock achene 5-15 part, Radix Glycyrrhizae 2- 10 parts.

Wherein bulk drug also has：Radix bupleuri 5-15 part, root of large-flowered skullcap 5-15 part.

Wherein bulk drug also has：Oroxylum indicum 10-30 part, Lasiosphaera fenzlii 10-20 part.

Wherein bulk drug also has：Root of kudzu vine 10-80 part, Bulbus Fritillariae Cirrhosae 5-20 part.

The technical solution adopted for the present invention to solve the technical problems is：The Chinese drug-treated group of Chinese traditional treatment respiratory virus infection Compound, including the bulk drug of following parts by weight：Perilla leaf 5-20 gram, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-15 gram, ching-chieh 5-25 gram, aster 5-20 Gram, 5-15 gram of almond, roasted perilla fruit 5-20 gram, wind-weed 3-15 gram, fritillaria thunbergii 3-15 gram, great burdock achene 5-25 gram, 2-15 gram of Radix Glycyrrhizae.

Preferable amount is：Perilla leaf 5-15 gram, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-10 gram, ching-chieh 5-15 gram, aster 5-15 gram, almond 5-10 Gram, roasted perilla fruit 5-10 gram, wind-weed 3-10 gram, fritillaria thunbergii 3-10 gram, great burdock achene 5-15 gram, 2-10 gram of Radix Glycyrrhizae.

The preparation method of medicine of the present invention is as follows：

Take bulk drug perilla leaf, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, ching-chieh, aster, almond, roasted perilla fruit, the wind-weed, fritillaria thunbergii, great burdock achene, Radix Glycyrrhizae add Soak by water merging filtrate, concentration, cooling, adding ethanol makes alcohol content 20-80%, reclaims ethanol, makes supernatant concentration become thick paste, standby With.Add capsule to commonly use auxiliary material the thick paste of preparation, be dried, pulverize loading capsule, can be prepared as treating Respirovirus The capsule infecting；Or thick paste and granule are commonly used auxiliary material mix, pelletize, be dried and be distributed into bag, treatment can be prepared as and exhale Inhale the granule that road virus infects；Or thick paste and oral liquid are commonly used auxiliary material mix, boil, be diluted with water, stand, filter, mixed It even is distributed into bottle, can be prepared as treating the oral liquid of respiratory virus infection；Or thick paste is added sucrose, flavouring, anticorrosion Agent, boils, and is diluted with water to 1000ml, stands, and filters, and mixes, and packing must treat the sugar of respiratory viral infection disease Slurry, wherein said sucrose weight ＞ 450g, described flavouring is stevioside, saccharin sodium, acesulfame-K, glycyrrhizin, thiacyclohexane ammonia Base sulfonic acid, asparagine, alcohol sugar, radix asparagi sweet extract, menthol, various essence and various fruity material, consumption is 0.1 ~ 10%, described Preservative be sorbic acid and k-na salt consumption be ＜ the 0.3%th, methyl hydroxybenzoate class consumption be ＜ 0.05%, described packing uses Packaging material is vial, plastic bottle；Or the thick paste of preparation and tablet are commonly used auxiliary material mix, compressing tablet, can be prepared as treatment breathe The tablet that road virus infects.

If also combined with raw material radix bupleuri, the root of large-flowered skullcap, its preparation method is：

Take bulk drug perilla leaf, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, ching-chieh, aster, almond, roasted perilla fruit, the wind-weed, fritillaria thunbergii, great burdock achene, Radix Glycyrrhizae, Radix bupleuri, the root of large-flowered skullcap add boiling water merging filtrate, concentration, cooling, and adding ethanol makes alcohol content 20-80%, reclaims ethanol, makes supernatant dense Shorten thick paste into, standby.Add capsule to commonly use auxiliary material the thick paste of preparation, be dried, pulverize loading capsule, treatment can be prepared as The capsule of respiratory virus infection；Or thick paste and granule are commonly used auxiliary material mix, pelletize, be dried and be distributed into bag, can make The granule of standby one-tenth treatment respiratory virus infection；Or thick paste and oral liquid are commonly used auxiliary material mix, boil, be diluted with water, quiet Put, filter, mix and be distributed into bottle, can be prepared as treating the oral liquid of respiratory virus infection；Or thick paste is added sucrose, rectifys Taste agent, preservative, boil, and is diluted with water to 1000ml, stands, and filters, and mixes, and packing obtains treatment respiratory virus infection The syrup of property disease, wherein said sucrose weight ＞ 450g, described flavouring is stevioside, saccharin sodium, acesulfame-K, glycyrrhizin Element, thiacyclohexane sulfamic acid, asparagine, alcohol sugar, radix asparagi sweet extract, menthol, various essence and various fruity material, consumption is 0.1 ~ 10%, described preservative be sorbic acid and k-na salt consumption be ＜ the 0.3%th, methyl hydroxybenzoate class consumption be ＜ 0.05%, institute The packaging material stating packing use is vial, plastic bottle；Or the thick paste of preparation and tablet are commonly used auxiliary material mix, compressing tablet, can make The tablet of standby one-tenth treatment respiratory virus infection.

If also combined with raw material Oroxylum indicum, Lasiosphaera fenzlii, its preparation method is：

Take bulk drug perilla leaf, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, ching-chieh, aster, almond, roasted perilla fruit, the wind-weed, fritillaria thunbergii, great burdock achene, Radix Glycyrrhizae, Radix bupleuri, the root of large-flowered skullcap, Oroxylum indicum, Lasiosphaera fenzlii add boiling water merging filtrate, concentration, cooling, and adding ethanol makes alcohol content 20-80%, reclaims second Alcohol, makes supernatant concentration become thick paste, standby.Add capsule to commonly use auxiliary material the thick paste of preparation, be dried, pulverize loading capsule, Can be prepared as treating the capsule of respiratory virus infection；Or thick paste and granule commonly used auxiliary material mix, pelletize, be dried and point Dress up bag, can be prepared as treating the granule of respiratory virus infection；Or thick paste and oral liquid are commonly used auxiliary material mix, boil Boiling, is diluted with water, and stands, and filters, and mixes and is distributed into bottle, can be prepared as treating the oral liquid of respiratory virus infection；Or will Thick paste adds sucrose, flavouring, preservative, boils, is diluted with water to 1000ml, stands, and filters, and mixes, and packing obtains treatment The syrup of respiratory viral infection disease, wherein said sucrose weight ＞ 450g, described flavouring be stevioside, saccharin sodium, Acesulfame-K, glycyrrhizin, thiacyclohexane sulfamic acid, asparagine, alcohol sugar, radix asparagi sweet extract, menthol, various essence and various fruit Taste substance, consumption is 0.1 ~ 10%, and described preservative is sorbic acid and k-na salt consumption is that ＜ the 0.3%th, methyl hydroxybenzoate class consumption is ＜ 0.05%, the packaging material that described packing uses is vial, plastic bottle；Or the thick paste of preparation and tablet are commonly used auxiliary material mix, Compressing tablet, can be prepared as treating the tablet of respiratory virus infection.

If also combined with the raw material root of kudzu vine, Bulbus Fritillariae Cirrhosae, its preparation method is：

Take bulk drug perilla leaf, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, ching-chieh, aster, almond, roasted perilla fruit, the wind-weed, fritillaria thunbergii, great burdock achene, Radix Glycyrrhizae, Radix bupleuri, the root of large-flowered skullcap, Oroxylum indicum, Lasiosphaera fenzlii, the root of kudzu vine, Bulbus Fritillariae Cirrhosae add boiling water merging filtrate, concentration, cooling, and adding ethanol makes alcohol content 20- 80%, reclaim ethanol, make supernatant concentration become thick paste, standby.Add capsule to commonly use auxiliary material the thick paste of preparation, be dried, pulverize Load capsule, can be prepared as treating the capsule of respiratory virus infection；Or thick paste and granule are commonly used auxiliary material mix, system Grain, is dried and is distributed into bag, can be prepared as treating the granule of respiratory virus infection；Or thick paste and oral liquid are commonly used auxiliary Material mixing, boils, is diluted with water, and stands, and filters, and mixes and is distributed into bottle, can be prepared as treating the mouth of respiratory virus infection Take liquid；Or thick paste is added sucrose, flavouring, preservative, boil, be diluted with water to 1000ml, stand, filter, mix, point Dress, must treat the syrup of respiratory viral infection disease, and wherein said sucrose weight ＞ 450g, described flavouring is stevia rebaudianum Glycosides, saccharin sodium, acesulfame-K, glycyrrhizin, thiacyclohexane sulfamic acid, asparagine, alcohol sugar, radix asparagi sweet extract, menthol, various perfume (or spice) Smart and various fruity material, consumption is 0.1 ~ 10%, and described preservative is sorbic acid and k-na salt consumption is ＜ the 0.3%th, oxybenzene first Esters consumption is ＜ 0.05%, and the packaging material that described packing uses is vial, plastic bottle；Or the thick paste of preparation and tablet are commonly used Auxiliary material mixing, compressing tablet, can be prepared as treating the tablet of respiratory virus infection.

Chinese medicine composition of the present invention can be prepared as formulation described in any pharmacy：Capsule, oral liquid, particle Agent, syrup, tablet, effervescence granular, dripping pill, aerosol, spray, gargarisma, mouthwash；Wherein said tablet be oral disintegrating tablet, Effervescent tablet.

Medicament selection perilla leaf of the present invention, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, ching-chieh, aster, almond, roasted perilla fruit, the wind-weed, fritillaria thunbergii, ox Burdock, Radix Glycyrrhizae are combined.These drug regimens make each efficacy of drugs produce synergy such that it is able to effectively treatment is exhaled Inhale road virus to infect.Wherein perilla leaf is pungent, tepor, nontoxic, returns spleen, lung two warp, and dispelling wind declares lung, in promoting the circulation of qi width,《Compendium of Materia Medica》 Cloud：" in promoting the circulation of qi width, dissolving phlegm profit lung, and blood, Wen Zhong, pain relieving, Dingchuan, antiabortive.”；The bark of official magnolia is bitter, pungent, temperature, and function is eliminating dampness and eliminating phlegm, fall Gas cough-relieving《Do not record》Cloud " gas under dissolving phlegm ",《Property of medicine opinion》Cloud " eliminating phlegm is drunk, and goes to bear water ".《Book on Chinese herbal medicine converges to be sayed》Say：" all wet smouldering and not Going, wet phlegm is poly-and does not disappears, with the temperature of the bark of official magnolia can with eliminating dampness, pungent can be with dissolving phlegm, hardship can following gas." there is out chest promoting the circulation of qi, eliminating dampness is removed Phlegm, the work(relievingd asthma.Modern pharmacology research show, the bark of official magnolia have affect stomach and intestine movable, antibacterial, antiviral, of flaccid muscles and in Pivot suppression, antiallergy etc. act on.The clear purte the white of the wind-weed, nourshing Yin and drynsessmoistening prescription,《Japan hanako materia medica》：" logical small intestine, dissolving phlegm is only coughed, and moistens the heart Lung, qi-restoratives is weary, feels at ease only to palpitate with fear." three is monarch drug in a prescription altogether, plays wind and heat dispersing, relieving cough and asthma work(altogether.Schizonepeta is pungent, tepor is returned Lung, Liver Channel, have effect of induce sweat scattered wind, promoting eruption；Helping perilla leaf a surname and sending out lung qi, saturating heresy is gone out.Almond bitter, fall profit lung qi and Relieving asthma；Matching with Su Ye then declares fall suitable, matches then clear respectful collaborative with the wind-weed.Fritillaria thunbergii clearing lung and eliminating phlegm cough-relieving；Share with the wind-weed Play clearing away the lungheat and moisturizing altogether, effect of preventing phlegm from forming and stopping coughing.Three dissipates ailment said due to cold or exposure for ministerial drug principal drug assistance a surname altogether, relieving cough and asthma.The pungent Wen Errun of perillaseed, Its main fall of property, is longer than fall lung qi dissolving phlegm, stops up the key medicine of circulation of vital energy in the wrong direction fullness sensation in chest for treatment phlegm, and arrogates to oneself and relax bowel, makes intestines internal organs unobstructed and help The respectful fall of lung,《Herbal classic meets source》Call it " cough except dihydroxypropyltheophylline, pleasant good dose of dissolving phlegm." and almond share, then the circulation of vital energy in the wrong direction is coughed and is breathed heavily and can solve.Purple Garden bitter and gentle, have gasified phlegm, the work(that reason lung is only coughed；Great burdock achene is pungent, bitter, cold in nature, attaches to the lung and stomach meridians, dispelling wind and heat from the body, heat-clearing Removing toxic substances promoting eruption, a surname's lung profit pharynx dissipate swollen；The two altogether be adjutant, help monarch-minister drug reduce phlegm profit pharynx, sending down abnormally ascending cough-relieving.The raw use of Radix Glycyrrhizae, is in harmonious proportion all Medicine, and energy cough-relieving, hold concurrently and make for assistant.All medicine compatibilities, outer dispersing wind and cold, interior clear phlegm heat, dispersing and lowering lung-QI, make lung heat clear, outer heresy dissipates, inverse gas Fall, phlegm turbidity and cough and breathe heavily flat.

For the curative effect having reached, medicine of the present invention also combines with radix bupleuri, the root of large-flowered skullcap.This is because the root of large-flowered skullcap is bitter, cold, return lung, Courage, spleen, large intestine, small intestinl channel；Function heat-clearing and damp-drying drug, purging intense heat and detonicating, it is good at clearing lung-heat stomach courage and large intestinal damp-heat, be especially longer than the clear middle part of the body cavity above the diaphragm housing the heart and lungs Damp and hot.Master enters lung channel, is apt to clear purte the white and the real heat of the part of the body cavity above the diaphragm housing the heart and lungs, thick with the cough phlegm controlled caused by lung heat heap soil or fertilizer over and around the roots is contained；Radix bupleuri reducing fever by reconciliation, Rise and lift yang-energy, with the root of large-flowered skullcap share one liter one clear, jointly discongest the heresy of part of the body cavity above the diaphragm housing the heart and lungs wind-heat.

For the curative effect having reached, medicine of the present invention also combines with Oroxylum indicum, Lasiosphaera fenzlii.This is because Oroxylum indicum：Cool in nature, return Lung, stomach, Liver Channel.Function removing heat from the lung and relieving sorethroat, soothing liver and harmonizing stomach, there is clearing lung-heat heat, effect of throat, be the key medicine controlling abscess of throat, There is again the work(of clearing lung and eliminating phlegm cough-relieving, be usually used in treating cough with lung heat；Lasiosphaera fenzlii is pungent, flat, enters lung channel, function：Removing heat from the lung and relieving sorethroat, solves Poison, hemostasis.Controlling larynx numbness pharyngalgia, cough with aphonia, spitting blood, bleeding from five sense organs or subcutaneous tissue, traumatism and bleeding, compatibility great burdock achene can dissipate wind and heat in the lung meridian and profit pharynx stops Cough.

In order to reach more preferable curative effect, medicine of the present invention also combines with the root of kudzu vine, Bulbus Fritillariae Cirrhosae.This is because root of kudzu vine energy expelling pathogenic factors from muscles and skin moves back Heat, promotes the production of body fluid, promoting eruption, rises sun antidiarrheal.《Book on Chinese herbal medicine justice》：" root of kudzu vine, uses this person, cool dissipates with it, though all yang channels of Starch 1500, and sun bright is , light with its gas, therefore kind sweating of inducing sweat.How hot the medicine of all dismission is, and this is solely cool and sweet, thus solve warm when row epidemic, Fan Re and Hold concurrently thirsty person, and this is the best." perilla leaf, ching-chieh expelling pathogenic factors from muscles and skin can be assisted to deliver, dispelling wind pathogens.Bulbus Fritillariae Cirrhosae moisten the lung and relieve the cough reduce phlegm flat Breathing heavily, effect of clearing heat and eliminating phlegm, experimental study shows that Bulbus Fritillariae Cirrhosae has antibechic, phlegm-dispelling functions.Use ammonia induced cough in mice experiment, Tissue cultures tendril-leaved fritillary bulb and wild tendril-leaved fritillary bulb, 3.0g/kg gavage, when 30 minutes, antitussive effect is the strongest, and cough-relieving rate is more than 50%, uses little Mouse PSP method is tested, and family plants and wild Bulbus Fritillariae Cirrhosae 200% liquid extract 25ml/kg, Bulbus Fritillariae Cirrhosae alkaloid 11.3mg/kg and shellfish Female saponin I～No. III 0.5mg/kg, all has more apparent expectorant effect.

Chinese medicine composition of the present invention is the experience used out of summing up in the clinical practice of antiviral property respiratory tract infection for many years Side, the experimental basis of science in addition, each component can play respective pharmacological action, can play again mutual synergy, make Pharmacological action enhancing, rationally, flavour of a drug refine formula, and the party is used for treating or preventing viral respiratory tract infection, determined curative effect, and Having no side effect, in popular period, all effective with prevention for treatment as general side, formulation and preparation technology are suitable for industrialization Produce in enormous quantities.

Detailed description of the invention

Present invention treatment or the Chinese medicine composition of prevention respiratory viral infection disease, including following parts by weight is former Material medicine：Perilla leaf 5-15 gram, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-10 gram, ching-chieh 5-15 gram, aster 5-15 gram, 5-10 gram of almond, roasted perilla fruit 5- 10 grams, wind-weed 3-10 gram, fritillaria thunbergii 3-10 gram, great burdock achene 5-15 gram, 2-10 gram of Radix Glycyrrhizae.For the curative effect having reached, the present invention Medicine can combine with bulk drug radix bupleuri, the root of large-flowered skullcap；In order to reach more preferable curative effect, medicine of the present invention also can be with bulk drug wood butterfly Butterfly, Lasiosphaera fenzlii combine；In order to obtain optimum curative effect, medicine of the present invention also can combine with the bulk drug root of kudzu vine, Bulbus Fritillariae Cirrhosae.

Embodiment 1：

Weighting raw materials perilla leaf 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae.Above ten herbal medicines totally 100 grams, add boiling water merging filter Liquid, concentration, cooling, add ethanol making alcohol content is 20-80%, reclaims ethanol, makes supernatant concentration become thick paste, standby.Add β-ring Dextrin, heating for dissolving, stirring, filtration, spray drying hot-air EAT 180 DEG C, leaving air temp 80 DEG C, spray powder adds to be adjusted Taste agent, mixes, material at a temperature of 40 DEG C dry granulation, whole grain, be distributed into bag, obtaining the present invention, to treat viral respiratory sick The granule that poison infects.

Embodiment 2：

Weighting raw materials perilla leaf 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae.Above ten herbal medicines totally 100 grams, add boiling water merging filter Liquid, concentration, cooling, add ethanol making alcohol content is 20-80%, reclaims ethanol, makes supernatant concentration become thick paste, standby.Add in thick paste Enter 95% ethanol of 2 times of cream weights, be sufficiently stirred for, left at room temperature 24～48h, take supernatant, sediment with 65% ethanol washing 1～ 2 times, cleaning solution merges with supernatant, if any alcohol extract, also merges with supernatant, filter clear and bright after, enter reduced pressure concentration tank or wine Essence recovery tower reclaims ethanol until liquid stops without alcohol taste.Liquid after dealcoholysis, after adding distilled water diluting, is heated to 100 DEG C, makes glue Body condenses, and adjusts pH4.5～5.0, then low temperature 0～4 DEG C refrigeration 24h, makes the colloidal precipitation of cohesion, then, filters to clear and bright, add Appropriate flavouring and preservative, after standing, then filter clear and bright, low-temp storage, filling before do last purification filtering, filtrate is put Detect under lamp inspection instrument clear and bright after, upper mechanical irrigation is encapsulated in straight tube easy open cover nutrition bottle, built-in 10ml ± 4% of every oral liquid bottle, to obtain final product The present invention treats the oral liquid of viral respiratory infection；Described flavouring be stevioside, saccharin sodium, acesulfame-K, glycyrrhizin, Thiacyclohexane sulfamic acid, asparagine, alcohol sugar, radix asparagi sweet extract, menthol, various essence and various fruity material, consumption is 0.1 ~ 10%, described preservative be sorbic acid and k-na salt consumption be ＜ the 0.3%th, methyl hydroxybenzoate class consumption be ＜ 0.05%.

Embodiment 3：

Weighting raw materials perilla leaf 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae, radix bupleuri 10 grams, the root of large-flowered skullcap 10 grams.Above 12 herbal medicines are altogether 120 grams, then the method as described in embodiment 1 makes granule.

Embodiment 4：

Weighting raw materials perilla leaf 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae, radix bupleuri 10 grams, the root of large-flowered skullcap 10 grams.Above 12 herbal medicines are altogether 120 grams, then the method as described in embodiment 2 makes oral liquid.

Embodiment 5：

Weighting raw materials perilla leaf 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae, radix bupleuri 10 grams, the root of large-flowered skullcap 10 grams, Oroxylum indicum 10 grams, Lasiosphaera fenzlii 10 grams.Above ten four traditional Chinese medicine things totally 140 grams, then the method as described in embodiment 1 makes granule.

Embodiment 6：

Weighting raw materials perilla leaf 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae, radix bupleuri 10 grams, the root of large-flowered skullcap 10 grams, Oroxylum indicum 10 grams, Lasiosphaera fenzlii 10 grams.Above ten four traditional Chinese medicine things totally 140 grams, then the method as described in embodiment 2 makes oral liquid.

Embodiment 7：

Weighting raw materials perilla leaf 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae, radix bupleuri 10 grams, the root of large-flowered skullcap 10 grams, Oroxylum indicum 10 grams, Lasiosphaera fenzlii 10 grams, the root of kudzu vine 10 grams, Bulbus Fritillariae Cirrhosae 5 grams.Above ten six medicaments totally 155 grams, then the method as described in embodiment 1 is made Granula.

Embodiment 8：

Weighting raw materials perilla leaf 10 grams, ching-chieh 10 grams, aster 10 grams, 10 grams of almond, roasted perilla fruit 10 grams, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10 Gram, the wind-weed 10 grams, fritillaria thunbergii 10 grams, great burdock achene 10 grams, 10 grams of Radix Glycyrrhizae, radix bupleuri 10 grams, the root of large-flowered skullcap 10 grams, Oroxylum indicum 10 grams, Lasiosphaera fenzlii 10 grams, the root of kudzu vine 10 grams, Bulbus Fritillariae Cirrhosae 5 grams.Above ten six medicaments totally 155 grams, then the method as described in embodiment 2 makes mouth Take liquid.

Test example 1：The Germicidal efficacy of Chinese medicine composition In Vitro Anti rhinovirus (HRV, N36)

Test philosophy：With Human embryo epithelial cell as virus host, measure sample suppression rhinovirus and cause Human embryo epithelial cell Lesion degree.

Test material and method：1. Strain：Rhinovirus (HRV, N36).

. sample treatment:Example the 1st, the 3rd, the 5th, 7 prepare thick pastes be dissolved in water and be respectively prepared the solution of 1000mg/ml Bottle standby；3000rpm takes supernatant after centrifuging 20 minutes, and the sodium citrate with 50% adjusts pH7.2～7.6, is poured into sterile test tube In, 121 DEG C, 15 20 minutes autoclavings, take out in rearmounted 4 DEG C of refrigerators and save backup；Solution example nutrient solution during experiment 1:10 dilutions start, and make 2 times of dilutions, totally 8 dilution factors.

3. positive control drug：Ribavirin (RBV) Jiangxi Huiren Pharmaceutical Co., Ltd produces.

4. method of testing：

1. by Human embryo epithelial cell（2～4）×10⁵0.1ml is inoculated into 96 hole micro plastics culture plates, every hole 100 μ l 37 DEG C, 5%CO₂Cultivate 1～2 day, grow into cell monolayer.Cell growth medium is MEM100ml, the 10%th, 3% glutamy containing hyclone Amine the 1%th, penicillin and streptomysin each 100U/ml, NaHCO3 5%；When cell grows up to individual layer, abandon growth-promoting media, need before virus inoculation to use PBS or the Hanks liquid of pre-temperature washes cell two times.

2. drain, add 100 μ l 10～100TCID₅₀Viral suspension infection cell, 37 DEG C of absorption 1～2h, abandon virus liquid, Add the maintenance liquid 100 μ l containing variable concentrations testing compound again, each concentration 2 hole, 37 DEG C of 5%CO₂Incubation continues Cultivate.If normal cell controls, drug toxicity control, virus control, Ribavirin (RBV) positive control and virus TCID₅₀Drip Fixed.

3. check under inverted microscope and record cytopathy every day（<25% be a plus sige, 25_~50% is two adds Number, 50_~75% be three plus siges, 75_~100% is four plus siges）, until virus control wells（It is not added with testing compound）Occur 3_~4 It is experimental endpoints during the cytopathy of individual plus sige.Record each porocyte lesion degree, calculate and often organize average cell lesion degree, with Virus control group compares, and calculates suppression 50% cytopathic compound concentration i.e. half suppression by Reed and Muench method dense Degree（IC₅₀）.

4. press the toxicity to cell for the criterion calculation medicine 3. simultaneously, calculate generation 50% by Reed and Muench method thin The compound concentration of born of the same parents' pathology i.e. half toxic concentration（TD₅₀）.

⑤ TD₅₀/ IC₅₀For selecting index（SI）.

5. experimental result

Test example 2：The Germicidal efficacy of Chinese medicine composition In Vitro Anti influenza virus A type

Test philosophy：With MDCK (MDCK) as virus host, measure sample suppression influenza virus A type and cause mdck cell Lesion degree.

Test material and method：

1. Strain：/ 243/72 (H3N2) is prevented in influenza virus A type A/ Guangdong.

2. sample treatment:Example the 2nd, the 4th, the 6th, 8 prepare thick pastes be dissolved in water and be respectively prepared the molten of 1000mg/ml Liquid bottling is standby；3000rpm takes supernatant after centrifuging 20 minutes, and the sodium citrate with 50% adjusts pH7.2～7.6, is poured into aseptic examination Guan Zhong, 121 DEG C, 15 20 minutes autoclavings, take out in rearmounted 4 DEG C of refrigerators and save backup；During experiment, solution example is cultivated Liquid 1:10 dilutions start, and make 2 times of dilutions, totally 8 dilution factors.

3. positive control drug：Tamiflu.

4. method of testing：1. by mdck cell（2～4）× 10⁵0.1ml is inoculated into 96 hole micro plastics culture plates, often Hole 100 μ l 37 DEG C, 5%CO₂Cultivate 1～2 day, grow into cell monolayer.Cell growth medium is MEM 100ml, contains hyclone 10%th, 3% glutamine the 1%th, penicillin and streptomysin each 100U/ml, NaHCO3 5%；Maintain liquid not increase serum, because serum includes Have the nonspecific inhibitor that suppression influenza virus is replicated, when cell grows up to individual layer, need before virus inoculation with the PBS of pre-temperature or Hanks liquid washes cell two times, to remove the growth-promoting media containing cow's serum of residual, substitutes cow's serum with 1% albumin 10%, and adds 0.25% pancreatin 0.2%, the same growth-promoting media of other compositions.

2. abandon growth-promoting media, drain, add 100 μ l 10～100TCID₅₀Viral suspension infection cell, 37 DEG C of absorption 1～2h, Abandon virus liquid, then add the maintenance liquid 100 μ l containing variable concentrations testing compound, each concentration 2 hole, 37 DEG C of 5%CO₂Temperature Case hatches continuation cultivation.If normal cell controls, drug toxicity control, virus control, Ribavirin (RBV) positive control and disease Poison TCID₅₀Titration.

3. check under inverted microscope and record cytopathy every day（<25% be a plus sige, 25_~50% is two adds Number, 50_~75% be three plus siges, 75_~100% is four plus siges）, until virus control wells（It is not added with testing compound）Occur 3_~4 It is experimental endpoints during the cytopathy of individual plus sige.Record each porocyte lesion degree, calculate and often organize average cell lesion degree, with Virus control group compares, and calculates suppression 50% cytopathic compound concentration i.e. half suppression by Reed and Muench method dense Degree（IC50）.

⑤ TD₅₀/ IC₅₀For selecting index（SI）.

5. experimental result

Test example 3：The clinical observation of traditional Chinese medicine composition for treating rhinovirus ALRI

1.1 data and method

1.1.1 clinical data

This group case is the patient of the rhinovirus ALRI that in December, 2013 in December, 2015 makes a definite diagnosis, age 1 ~ 72 In year, meeting the patient of following traditional Chinese and western medicine diagnostic criteria, 120 case patients are randomly divided into treatment group（Chinese medicine composition）60 cases, comparison Group（Ribavirin）60 cases.Treatment group 60 case is assigned randomly to embodiment example the 1st, the 3rd, the 5th, 7 groups（It is called for short treatment group A, B, C, D）Respectively 15 cases, control group 60 case is randomly divided into four groups（It is called for short control group A, B, C, D）Each 15 cases, two groups in sex, age, the course of disease and disease Not statistically significant (P on mutual affection cloth>0.05).

1.1.2 diagnostic criteria

1.1.2.1 doctor trained in Western medicine diagnostic criteria

（1）Clinical symptoms:Have the rhinovirus infection medical history of affirmative, Acute onset, the course of disease≤3 day；With generating heat, cough, cough up phlegm, Nasal mucus, trachyphonia, stridulate, the symptom such as shortness of breath；

（2）Health check-up:Congestion of throat, regional nodes's silght enlargement or tenderness, two lung audibles and dryness or moist rale；

（3）Laboratory examination：Using RT-PCR method detection rhinovirus positive, peripheral blood conventional white cell count and classification are all just Between normal scope or white blood cell count(WBC) is low；

（4）X-ray rabat or CT examination show bronchitis or pneumonia.

1.1.2.2 tcm diagnosis standard：

Clinical symptoms to generate heat, aversion to cold, cough, cough up phlegm, nasal mucus, trachyphonia, the circulation of vital energy in the wrong direction, shortness of breath, stridulate as principal character, reddish tongue, The thin Huang of tongue, arteries and veins are sliding.

1.2 treatment method

Treatment group gives Chinese medicine composition, and oral, twice daily, each consumption is equivalent to each raw medicinal herbs 10g；Control group profit bar Wei Lin effervescence granular 150mg/ time, three times a day, oral.Children are cut down according to the circumstance.The course for the treatment of is 7 days.

1.3 criterion of therapeutical effect

Criterion of therapeutical effect：

Recovery from illness：Treat seven days internal heat generation aversion to cold, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, the Clinical symptom and sign such as shortness of breath Disappear；

Effective：Treat seven days internal heat generation aversion to cold, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, the Clinical symptom and sign such as shortness of breath Mitigate more than 2/3；

Effectively：Treat seven days internal heat generation aversion to cold, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, the Clinical symptom and sign such as shortness of breath Mitigate 2/3～1/3；

Invalid：Feel in treating seven days or other symptoms are all not improved or increase the weight of.

1.4 result

Use the Chinese medicine composition of embodiment of the present invention example 1（Treatment group A）Treatment rhinovirus ALRI, result table Bright：Fever with chilliness before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, shortness of breath Improve situation, treatment group A clinical improvements total effective rate 62.98% etc. clinical symptoms；Control group A clinical improvements total effective rate 33.69%；Treatment group A and control group A comparing difference statistically significant (P ＜ 0.05).Poison is not found in clinical treatment observation Side effect.Clinical effectiveness is pointed out：Embodiment of the present invention example 1 traditional Chinese medicine composition for treating rhinovirus ALRI curative effect is full Meaning, in terms of alleviating clinical symptoms time and total effective rate and cure rate, Chinese drug-treated group is superior to Ribavirin group.

Use the Chinese medicine composition of embodiment of the present invention example 3（Treatment group B）Treatment rhinovirus ALRI, result Show：Fever with chilliness before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, gas The clinical symptoms such as rush improve situation, treatment group B clinical improvements total effective rate 86.96%；Control group B clinical improvements total effective rate 38.49%；Treatment group B and control group B comparing difference statistically significant (P ＜ 0.05).Poison is not found in clinical treatment observation Side effect.Clinical effectiveness is pointed out：Embodiment of the present invention example 3 traditional Chinese medicine composition for treating rhinovirus ALRI curative effect is full Meaning, in terms of alleviating clinical symptoms time and total effective rate and cure rate, Chinese drug-treated group is superior to Ribavirin group.

Use the Chinese medicine composition of embodiment of the present invention example 5（Treatment group C）Treatment rhinovirus ALRI, result Show：Fever with chilliness before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, gas The clinical symptoms such as rush improve situation, treatment group C clinical improvements total effective rate 74.43%；Control group C clinical improvements total effective rate 42.87%；Treatment group C and control group C comparing difference statistically significant (P ＜ 0.05).Poison is not found in clinical treatment observation Side effect.Clinical effectiveness is pointed out：Embodiment of the present invention example 5 traditional Chinese medicine composition for treating rhinovirus ALRI curative effect is full Meaning, in terms of alleviating clinical symptoms time and total effective rate and cure rate, Chinese drug-treated group is superior to Ribavirin group.

Use the Chinese medicine composition of embodiment of the present invention example 7（Treatment group D）Treatment rhinovirus ALRI, result Show：Fever with chilliness before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, gas The clinical symptoms such as rush improve situation, treatment group D clinical improvements total effective rate 69.23%；Control group D clinical improvements total effective rate 39.69%；Treatment group D and control group D comparing difference statistically significant (P ＜ 0.05).Poison is not found in clinical treatment observation Side effect.Clinical effectiveness is pointed out：Embodiment of the present invention example 7 traditional Chinese medicine composition for treating rhinovirus ALRI curative effect is full Meaning, in terms of alleviating clinical symptoms time and total effective rate and cure rate, Chinese drug-treated group is superior to Ribavirin group.

Test example 4：The clinical observation that traditional Chinese medicine composition for treating influenza B virus infects

1.1 data and method

1.1.1 clinical data

This group case is the patient that the influenza B virus made a definite diagnosis in June, 2013 in March, 2016 infects, 6 ~ 69 years old age, Meeting the patient of following traditional Chinese and western medicine diagnostic criteria, 120 case patients are randomly divided into treatment group（Chinese medicine composition）60 cases, control group （Ribavirin）60 cases.Treatment group 60 case is assigned randomly to embodiment example the 2nd, the 4th, the 6th, 8 groups（It is called for short treatment group A, B, C, D）Each 15 Example, control group 60 case is randomly divided into four groups（It is called for short control group A, B, C, D）Each 15 cases, two groups in sex, age, the course of disease and the state of an illness Not statistically significant (P in distribution>0.01).

1.1.2 diagnostic criteria

1.1.2.1 doctor trained in Western medicine diagnostic criteria

（1）Clinical symptoms:Have the influenza infection medical history of affirmative, Acute onset, the course of disease≤2 day；With generating heat, cough up phlegm, sound Neigh, pharyngalgia, the circulation of vital energy in the wrong direction, the symptom such as shortness of breath；

（2）Health check-up:Body temperature raises, congestion of throat, regional nodes's silght enlargement or tenderness, two lung audibles and dryness or moist sieve Sound；

（3）Laboratory examination：Use RT-PCR method detection influenza B virus positive, peripheral blood conventional white cell count and classification All between normal range (NR) or white blood cell count(WBC) is low；

（4）X-ray rabat or CT examination show bronchitis or pneumonia.

1.1.2.2 tcm diagnosis standard：

Clinical symptoms to generate heat, to cough, to cough up phlegm, trachyphonia, pharyngalgia, the circulation of vital energy in the wrong direction, shortness of breath as principal character, reddish tongue, the thin Huang of tongue, arteries and veins are sliding Number.

1.2 treatment method

1.3 criterion of therapeutical effect

Criterion of therapeutical effect：

Recovery from illness：Treat internal heat generation in seven days, cough, cough up phlegm, trachyphonia, pharyngalgia, the circulation of vital energy in the wrong direction, the Clinical symptom and sign such as shortness of breath disappear；

Effective：Treat internal heat generation in seven days, cough, cough up phlegm, trachyphonia, pharyngalgia, the circulation of vital energy in the wrong direction, the Clinical symptom and sign such as shortness of breath mitigate 2/3 with On；

Effectively：Treat internal heat generation in seven days, cough, cough up phlegm, trachyphonia, pharyngalgia, the circulation of vital energy in the wrong direction, the Clinical symptom and sign such as shortness of breath mitigate 2/3～ 1/3；

1.4 result

Use the Chinese medicine composition of embodiment of the present invention example 2（Treatment group A）Controlling influenza B virus to infect, result shows：Ratio Generate heat compared with before and after two groups of patient's total effective rates and medication, cough, cough up phlegm, trachyphonia, pharyngalgia, the circulation of vital energy in the wrong direction, the clinical symptoms such as shortness of breath are improved Situation, treatment group A clinical improvements total effective rate 69.46%；Control group A clinical improvements total effective rate 36.09%；Treatment group A with right According to group A comparing difference statistically significant (P ＜ 0.01).Toxic and side effect is not found in clinical treatment observation.Clinical effectiveness carries Show：Embodiment of the present invention example 2 traditional Chinese medicine composition for treating influenza B virus ALRI satisfactory effect, is alleviating clinic Symptom time and total effective rate and cure rate aspect Chinese drug-treated group are superior to Ribavirin group.

Use the Chinese medicine composition of embodiment of the present invention example 4（Treatment group B）Treatment influenza B virus infects, result table Bright：Generate heat before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, trachyphonia, pharyngalgia, the circulation of vital energy in the wrong direction, the clinical symptoms such as shortness of breath Improvement situation, treatment group B clinical improvements total effective rate 79.91%；Control group B clinical improvements total effective rate 39.55%；Treatment group B Statistically significant with control group B comparing difference (P ＜ 0.01).Toxic and side effect is not found in clinical treatment observation.Clinical knot Fruit prompting：Embodiment of the present invention example 4 traditional Chinese medicine composition for treating influenza B virus ALRI satisfactory effect, is alleviating Clinical symptoms time and total effective rate and cure rate aspect Chinese drug-treated group are superior to Ribavirin group.

Use the Chinese medicine composition of embodiment of the present invention example 6（Treatment group C）Treatment influenza B virus lower respiratory tract sense Dye, result shows：Fever with chilliness before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, The clinical symptoms such as the circulation of vital energy in the wrong direction, shortness of breath improve situation, treatment group C clinical improvements total effective rate 74.58%；Control group C clinical improvements always has Efficiency 42.76%；Treatment group C and control group C comparing difference statistically significant (P ＜ 0.01).Clinical treatment observation is not sent out Existing toxic and side effect.Clinical effectiveness is pointed out：Embodiment of the present invention example 6 traditional Chinese medicine composition for treating influenza B virus lower respiratory tract sense Dye satisfactory effect, in terms of alleviating clinical symptoms time and total effective rate and cure rate, Chinese drug-treated group is superior to Ribavirin group.

Use the Chinese medicine composition of embodiment of the present invention example 8（Treatment group D）Treatment influenza B virus infects, result table Bright：Fever with chilliness before and after relatively two groups of patient's total effective rates and medication, cough, cough up phlegm, nasal mucus, trachyphonia, stridulate, the circulation of vital energy in the wrong direction, shortness of breath Improve situation, treatment group D clinical improvements total effective rate 71.46% etc. clinical symptoms；Control group D clinical improvements total effective rate 37.26%；Treatment group D and control group D comparing difference statistically significant (P ＜ 0.01).Poison is not found in clinical treatment observation Side effect.Clinical effectiveness is pointed out：Embodiment of the present invention example 8 traditional Chinese medicine composition for treating influenza B virus infects satisfactory effect, In terms of alleviating clinical symptoms time and total effective rate and cure rate, Chinese drug-treated group is superior to Ribavirin group.

Above content is to combine concrete preferred embodiment further description made for the present invention, it is impossible to assert Being embodied as of the present invention is confined to these explanations.For general technical staff of the technical field of the invention, On the premise of without departing from present inventive concept, some simple deduction or replace can also be made, all should be considered as belonging to the present invention's Protection domain.

Claims

1. the Chinese medicine composition treating viral respiratory infection, it is characterised in that：Including the raw material of following parts by weight Medicine：Perilla leaf 5-20 part, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-15 part, ching-chieh 5-25 part, aster 5-20 part, almond 5-15 part, roasted perilla fruit 5-20 Part, wind-weed 3-15 part, fritillaria thunbergii 3-15 part, great burdock achene 5-25 part, Radix Glycyrrhizae 2-15 part.

2. the Chinese medicine composition for the treatment of viral respiratory infection according to claim 1, wherein the consumption of bulk drug is also Can be：Perilla leaf 5-15 part, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 1-10 part, ching-chieh 5-15 part, aster 5-15 part, almond 5-10 part, roasted perilla fruit 5-10 part, wind-weed 3-10 part, fritillaria thunbergii 3-10 part, great burdock achene 5-15 part, Radix Glycyrrhizae 2-10 part.

3. the Chinese medicine composition for the treatment of viral respiratory infection according to claim 2, wherein bulk drug also has：Radix bupleuri 5-15 part, root of large-flowered skullcap 5-15 part.

4. the Chinese medicine composition for the treatment of treatment viral respiratory infection according to claim 3, wherein bulk drug also has： Oroxylum indicum 10-30 part, Lasiosphaera fenzlii 10-20 part.

5. the Chinese medicine composition for the treatment of viral respiratory infection according to claim 4, wherein bulk drug also has：The root of kudzu vine 10-80 part, Bulbus Fritillariae Cirrhosae 5-20 part.

6. the Chinese medicine composition for the treatment of viral respiratory infection according to claims 1 to 5, it is characterised in that：Described The formulation of composition be：Capsule, oral liquid, granule, syrup, tablet, effervescence granular, dripping pill, aerosol, spray, contain Cough liquid, mouthwash；Wherein said tablet is oral disintegrating tablet, effervescent tablet.

7. the Chinese medicine composition for the treatment of viral respiratory infection according to claims 1 to 5, it is characterised in that：Clinical On can be used for treatment or prevention by influenza A virus, influenza B virus, rhinovirus, coronavirus, Respiratory Syncytial Virus(RSV), The respiratory viral infection disease that hand-foot-and-mouth disease poison, adenovirus, parainfluenza virus, echovirus, Coxsackie virus etc. are caused Sick.