CN110115739A

CN110115739A - A kind of Chinese medicine composition and preparation method thereof for treating disease of viral infection or cough variant asthma

Info

Publication number: CN110115739A
Application number: CN201810122362.6A
Authority: CN
Inventors: 齐继贵
Original assignee: Shenzhen Rui Laiguisheng Biological Medicine Science And Technology Ltd
Current assignee: Shenzhen Rui Laiguisheng Biological Medicine Science And Technology Ltd
Priority date: 2018-02-05
Filing date: 2018-02-05
Publication date: 2019-08-13

Abstract

The invention discloses treatment diseases of viral infection or the Chinese medicine composition of cough variant asthma and preparation method thereof: the composition includes the bulk pharmaceutical chemicals of following parts by weight: 1-30 parts of perilla leaf, 1-30 parts of aster, 1-30 parts of almond, 1-30 parts of perilla seed, 1-30 parts of rhizoma pinellinae praeparata, 1-30 parts of radix scutellariae, 1-30 parts of the root bark of white mulberry, 1-20 parts of Radix Glycyrrhizae.Above-mentioned crude drug is equipped with auxiliary material and corrigent, and a variety of dosage forms such as acceptable capsule, oral solution, granule, syrup, tablet, effervescence granular, dripping pill, the water-bindered pill, condensed pill, soft capsule, aerosol, spray, gargarisma in pharmacy are directly or indirectly made by normal process steps.It can be clinically used for treating or preventing adenovirus infection disease or influenza B virus infectious diseases or cough variant asthma.

Description

A kind of Chinese medicine composition that treating disease of viral infection or cough variant asthma and Preparation method

Technical field

The invention belongs to technical field of traditional Chinese medicines, especially with regard to treatment disease of viral infection or cough variant asthma Chinese medicine composition and preparation method thereof.

Background technique

Cough variant asthma is also known as cough type asthma or allergic cough, is a kind of bronchial asthma of specific type, Clinically be mainly shown as duration or chronic cough, without obviously wheeze, the symptom or signs such as shortness of breath, but have airway hyper-reaction Property, coughing fit can be made to alleviate using bronchodilator.Due to the Special Clinical Manifestation of cough variant asthma, often by mistaken diagnosis Or fail to pinpoint a disease in diagnosis, many patients are eventually developed to by delay treatment as bronchial asthma.Therefore how to early diagnose, early treatment is The problem that physician faces.

Cough variant asthma clinical symptoms are mainly shown as irritation, dry persistent coughs, and usually cough is more violent.Cough Cough it is lasting generation or recurrent exerbation one month or more.It especially go to bed at night or morning is obvious, it is the most common with spring, autumn, Breaking-out is frequent, violent, the symptoms such as many patients itch with throat, have a stuffy nose；Small number of patients idol audible and larynx when coughing violent Middle wheezing.Often after respiratory tract infection, strenuous exercise, cold air sucking, contact allergy source due to induce and aggravate；It can also be because of sucking Penetrating odor (paint, gasoline, oil smoke, perfume, pollen etc.) and break out；Also there are some patientss no any inducement the case where Lower breaking-out.This disease can be without obvious positive sign.Double pulmonary respiration sounds are slightly coarse when physical examination, idol audible and are dispersed in a little when coughing violent Wheezing sound can disappear after cough.

Studies at home and abroad show that the pathogenic factor of cough variant asthma is mainly the following aspects: infective agent, something lost Biography factor, environment and chemical factors, triggering factors.Wherein infective agent is unanimously listed in first place by external expert, it is believed that virus sense Dye causes airway tissue to damage, and makes vagus nerve fibers exposure, cholinergic nerve fibers sensitization, once stimulated cause branch gas The enhancing of pipe smooth muscle reflectivity, causes local tracheole to shrink, this shrinks stimulation tip cough receptor, directly causes cough anti- It penetrates, can there is no wheezing symptoms and sign, become with the variant asthma mainly showed of coughing.

At present for the western modern medicine conventional therapy of this disease: 1. hormone administration approach include sucking, oral and intravenous applications etc., Sucking is preferred approach.It can start Glucocorticoid Inhalation as early as possible after diagnosis cough variant asthma.External guide is recommended The dosage used is 200~400 μ g/d of 400~800 μ g/d of budesonide or fluticasone propionate, some cases may may require that Higher dosage.Such as it is applied alone glucocorticoid Inhalation in Treating that cannot alleviate symptom, the treatment of Ying Lianhe bronchodilators.2.β₂By Short-acting-the β of body agonist₂Receptor stimulating agent, common drug have salbutamol and Terbutaline etc..Do not recommend generally long-term independent Use long-acting-β₂Receptor stimulating agent, common drug have salmeterol and Formoterol etc..Recommend combination inhalation hormone in recent years With long-acting-β₂Receptor agonist treatment asthma.3. theophylline has the effect of diastole bronchial smooth muscle, and has heart tonifying, diuresis, expansion The effects of opening coronary artery, excited respiratory center and respiratory muscle.Oral administration is mostly used, symptoms last not alleviation person also can vein Administration.4. the common drug of leukotriene receptor antagonists has Montelukast Sodium, zafirlukast, Ibudilast etc..Division of chest disease, Britain is learned The therapeutic scheme for the cough variant asthma that can recommend includes short-acting β₂Receptor stimulating agent, inhaled and white three Alkene receptor antagonist.5. the common drug of anticholinergic agent has ipratropium bromide, bromination oxitropine and Tiotropium Bromide etc., relax It opens bronchial effect and compares β₂Receptor stimulating agent is weak, works also relatively slow, but prolonged application is not likely to produce drug resistance, to the elderly's Curative effect is not less than young man.This product and β₂Receptor stimulating agent use in conjunction has collaboration, complementation.

Some areas and hospital clinical usually add when treating this disease with antibiotic at present, and clinical practice proves plus uses antibiosis Extract for treating cannot mitigate cough variant asthma symptom and shorten the course of disease.The abuse of antibiotic not only causes the increasing of medical expenses Add, and easily reduce Abwehrkraft des Koepers, so as to cause suprainfection.

Traditional Chinese medicine thinks the etiology and pathogenesis of this disease, and caused by surely belonging to the invasion of healthy tendency virtual loss exopathogen, due to healthy tendency virtual loss, nothing is resisted strenuously With the passing of time heresy, disease and evil invade, influence a surname's drop function of lung, lead to disease recurrent exerbation.Therefore " body ressitance weakened while pathogenic factors prevailing " is then that its is most basic Pathomechanism.1. healthy tendency virtual loss is weakened body resistance with native endowment is insufficient or day after tomorrow asthenia of pulmonosplenic qi based on.Clinical findings with disease easily repeatedly Based on breaking-out, especially climate change easily induces this onste.2. exopathogen invades the disease always feels exopathogen again on the basis of weakened body resistance.Cough Variant asthma four seasons of coughing can all fall ill, and be broken out with spring and autumn in the majority, though " wind, cold, heat, wet, dry, fiery six gas all make us Cough ", but the reason of this disease is inventors believe that based on ailment said due to cold or exposure.3. the frequent diet raw food of eating and drinking without temperance or addiction tobacco and wine, sea The gas for injuring lung spleen such as fresh all makes body fluid not cloth, and cohesion is into cold phlegm, and interior volt is on lung and diaphragm, and mental disorder is mutually hit, and air flue is obstructed, Lung qi blocks and sends out cough and asthma etc..4. daily life imbalance clinical findings the occurrence of this disease and daily life imbalance also have certain relationship.It sleeps daytime Night is reverse, secretly consumes painstaking effort, breakdown of the normal physiological coordination between the heart and the kidney, and a surname that flaring up of deficient fire and ailment said due to cold or exposure hand over resistance to influence lung sends out drop respectful this can be caused sick.

This disease accounts for about 31.4% in the patient of chronic cough, is the common disease factor of chronic cough, due to often not with asthma Symptom is ceased, clinic is easily by mistaken diagnosis, or even prolongs and control, and develops into serious Asthma Status.Western medical treatment is with bronchodilator and suction Enter based on hormone, majority cannot adhere to treating for a long time, and the state of an illness is easy repeatedly, and cannot take into account virus infection factor.Therefore it researches and develops It is extremely urgent with the new medicine product for treating disease of viral infection or/and cough variant asthma simultaneously, it is to adapt to rule The inevitable outcome of the ever-increasing market demand of mould, and comply with socio-economic development and development in science and technology demand, have it is advanced, Importance and necessity.Chinese medicine has the characteristics that low drug resistance, side effect and adverse reaction is few, in treatment disease of viral infection Or there is unique advantage and vast potential for future development in terms of cough variant asthma.

Summary of the invention

Therefore, people preferably treat disease of viral infection to curative effect or the Chinese materia medica preparation of cough variant asthma exists Greatly demand.Up to now, it has not been found that any report in relation to pharmaceutical composition of the present invention.The present inventor is by repeatedly Research, and by antiviral study in vitro and the verifying repeatedly of clinical test, have finally found the treatment virus of more preferable curative effect The Chinese medicine composition of infectious diseases or cough variant asthma, so as to complete the present invention.This research is aiming at above-mentioned disease Because of the interpretation of the cause, onset and process of an illness, using targeted and Chinese herbal medicine with unique treatment disease of viral infection or cough variant asthma effect It is formulated.The composition mainly by perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae prepare and At with dispelling wind and heat, the function of ventilating the lung and relieving cough can be clinically used for treatment disease of viral infection or cough variant asthma.

The purpose of the present invention is: disease of viral infection can effectively be treated by overcoming the deficiencies of the prior art and provide one kind Or cough variant asthma and the Chinese medicine composition having no toxic side effect.

It is another object of the present invention to: the preparation method of the Chinese medicine composition is provided, meets the needs of market.

To reach better curative effect, drug of the present invention can be combined with bulk pharmaceutical chemicals radix bupleuri or/and cicada slough.

To reach better curative effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals Oroxylum indicum or/and myrobalan.

To reach better curative effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals schizonepeta or/and Chinese ephedra.

To reach better curative effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals PERICARPIUM TRICHOSANTHIS or/and dark plum.

To reach better curative effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals great burdock achene or/and tussilago.

To reach optimal curative effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals cordate houttuynia or/and Cortex Magnoliae Officinalis.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 1-30 parts of perilla leaf, 1-30 parts of aster, 1-30 parts of almond, 1-30 parts of perilla seed, 1-30 parts of rhizoma pinellinae praeparata, radix scutellariae 1- 30 parts, 1-30 parts of the root bark of white mulberry, 1-20 parts of Radix Glycyrrhizae.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae, 3-20 parts of radix bupleuri or/and 3-20 parts of cicada slough.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 3-20 parts of 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae, 3-20 parts of radix bupleuri or/and cicada slough, 3-20 parts of Oroxylum indicum or/and myrobalan 3-20 parts.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 3-20 parts of 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae, 3-20 parts of radix bupleuri or/and cicada slough, 3-20 parts of Oroxylum indicum or/and myrobalan 3-20 parts, 3-20 parts of schizonepeta or/and 3-20 parts of Chinese ephedra.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 3-20 parts of 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae, 3-20 parts of radix bupleuri or/and cicada slough, 3-20 parts of Oroxylum indicum or/and myrobalan 3-20 parts of 3-20 parts, 3-20 parts of schizonepeta or/and Chinese ephedra, 3-20 parts of PERICARPIUM TRICHOSANTHIS or/and 3-20 parts of dark plum.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 3-20 parts of 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae, 3-20 parts of radix bupleuri or/and cicada slough, 3-20 parts of Oroxylum indicum or/and myrobalan 3-20 parts of 3-20 parts of 3-20 parts, 3-20 parts of schizonepeta or/and Chinese ephedra, 3-20 parts of PERICARPIUM TRICHOSANTHIS or/and dark plum, 3-20 parts of great burdock achene or/ With 3-20 parts of tussilago.

A kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, with the original of following parts by weight Expect medicine composition: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 3-20 parts of 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae, 3-20 parts of radix bupleuri or/and cicada slough, 3-20 parts of Oroxylum indicum or/and myrobalan 3-20 parts of 3-20 parts of 3-20 parts, 3-20 parts of schizonepeta or/and Chinese ephedra, 3-20 parts of PERICARPIUM TRICHOSANTHIS or/and dark plum, 3-20 parts of great burdock achene or/ With 3-20 parts of tussilago, 5-25 parts of cordate houttuynia or/and 3-20 parts of Cortex Magnoliae Officinalis.

The technical solution adopted by the present invention to solve the technical problems is: treatment disease of viral infection or cough anomaly The Chinese medicine composition of asthma, the bulk pharmaceutical chemicals including following weight fraction: 1-30 parts of perilla leaf, 1-30 parts of aster, 1-30 parts of almond, 1-30 parts of perilla seed, 1-30 parts of rhizoma pinellinae praeparata, 1-30 parts of radix scutellariae, 1-30 parts of the root bark of white mulberry, 1-20 parts of Radix Glycyrrhizae.

Preferable amount are as follows: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, rhizoma pinellinae praeparata 3-20 Part, 3-20 parts of radix scutellariae, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae.

Drug of the present invention the preparation method is as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae.Add water to cook merging filtrate, It is concentration, cooling, add ethyl alcohol to make alcohol content 20-80% (percentage by volume, V/V, similarly hereinafter), recycles ethyl alcohol, be condensed into supernatant Thick paste, it is spare.Capsule is added in the thick paste of preparation and often uses auxiliary material, dry, crushing is packed into capsule, that is, can be prepared into treatment virus The capsule of infectious diseases or cough variant asthma；Or often mix thick paste with auxiliary material with granule, it pelletizes, dry and packing At bag, that is, it can be prepared into the granule for the treatment of disease of viral infection or cough variant asthma；Or it is thick paste is normal with oral solution It is mixed, is boiled with auxiliary material, is diluted with water, stood, filtering, mixing is distributed into bottle, that is, can be prepared into treatment disease of viral infection Or the oral solution of cough variant asthma；Or sucrose, corrigent, preservative is added in thick paste, it boils, is diluted with water to 1000ml is stood, and is filtered, and is mixed, and the syrup to get treatment disease of viral infection or cough variant asthma is dispensed, wherein The sucrose weight > 450g.

The corrigent is stevioside, saccharin sodium, acesulfame-K, glycyrrhizin, thiacyclohexane sulfamic acid, asparagine, alcohol One of sugar, radix asparagi sweet extract, menthol, various essence and various fruity material are several, and dosage is 0.1~10%；It is described Preservative is the sorbic acid of dosage < 0.3% and its methyl hydroxybenzoate class of k-na salt or dosage < 0.05%；The packing uses Packaging material be vial, plastic bottle.

If also in conjunction with bulk pharmaceutical chemicals radix bupleuri or/and cicada slough, preparation method are as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, radix bupleuri or/and cicada slough.Add Water decocts merging filtrate, concentration, cooling, and ethyl alcohol is added to make alcohol content 20-80% (V/V), recycles ethyl alcohol, is condensed into supernatant thick Cream, it is spare.Capsule is added in the thick paste of preparation and often uses auxiliary material, dry, crushing is packed into capsule, that is, can be prepared into treatment virus sense The capsule of infectious diseases or cough variant asthma；Or often mix thick paste with auxiliary material with granule, it pelletizes, dries and be distributed into Bag can be prepared into the granule for the treatment of disease of viral infection or cough variant asthma；Or thick paste and oral solution are commonly used Auxiliary material mixing, boil, be diluted with water, stand, filtering, mixing be distributed into bottle, that is, can be prepared into treatment disease of viral infection or The oral solution of cough variant asthma；Or sucrose, corrigent, preservative is added in thick paste, it boils, is diluted with water to 1000ml, It stands, filters, mix, the syrup to get treatment disease of viral infection or cough variant asthma is dispensed, wherein the sucrose Weight > 450g.

If also in conjunction with bulk pharmaceutical chemicals Oroxylum indicum or/and myrobalan, preparation method are as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, radix bupleuri or/and cicada It sloughs off, Oroxylum indicum or/and myrobalan.Merging filtrate, concentration, cooling are added water to cook, ethyl alcohol is added to make alcohol content 20-80% (V/V), is recycled Ethyl alcohol makes supernatant be condensed into thick paste, spare.Capsule is added in the thick paste of preparation and often uses auxiliary material, dry, crushing is packed into glue Capsule can be prepared into the capsule for the treatment of disease of viral infection or cough variant asthma；Or thick paste is commonly used with granule auxiliary Material mixing, granulation is dry and be distributed into bag, that is, can be prepared into the particle for the treatment of disease of viral infection or cough variant asthma Agent；Or often mix thick paste with auxiliary material with oral solution, it boils, is diluted with water, stand, filtering, mixing is distributed into bottle, can prepare At treatment disease of viral infection or the oral solution of cough variant asthma；Or sucrose, corrigent, preservative is added in thick paste, It boils, is diluted with water to 1000ml, stand, filter, mix, packing is to get treatment disease of viral infection or cough anomaly The syrup of asthma, wherein the sucrose weight > 450g.

If also in conjunction with bulk pharmaceutical chemicals schizonepeta or/and Chinese ephedra, preparation method are as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, radix bupleuri or/and cicada slough, wood Butterfly or/and myrobalan, schizonepeta or/and Chinese ephedra.Merging filtrate, concentration, cooling are added water to cook, ethyl alcohol is added to make alcohol content 20-80% (V/V), ethyl alcohol is recycled, supernatant is made to be condensed into thick paste, it is spare.Capsule is added in the thick paste of preparation and often uses auxiliary material, dry, powder Broken loading capsule can be prepared into the capsule for the treatment of disease of viral infection or cough variant asthma；Or by thick paste and particle Auxiliary material mixing is commonly used in agent, granulation, dry and be distributed into bag, that is, can be prepared into treatment disease of viral infection or cough anomaly is roared The granule of asthma；Or often mix thick paste with auxiliary material with oral solution, it boils, is diluted with water, stand, filtering, mixing is distributed into bottle, It can be prepared into the oral solution for the treatment of disease of viral infection or cough variant asthma；Or by thick paste be added sucrose, corrigent, Preservative boils, and is diluted with water to 1000ml, stands, and filters, and mixes, and packing is to get treatment disease of viral infection or cough The syrup of variant asthma, wherein the sucrose weight > 450g.

If also in conjunction with bulk pharmaceutical chemicals PERICARPIUM TRICHOSANTHIS or/and dark plum, preparation method are as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, radix bupleuri or/and cicada slough, wood Butterfly or/and myrobalan, schizonepeta or/and Chinese ephedra, PERICARPIUM TRICHOSANTHIS or/and dark plum.Merging filtrate, concentration, cooling are added water to cook, ethyl alcohol is added Make alcohol content 20-80% (V/V), recycles ethyl alcohol, supernatant is made to be condensed into thick paste, it is spare.Capsule is added in the thick paste of preparation Common auxiliary material, dry, crushing are packed into capsule, that is, can be prepared into the glue for the treatment of disease of viral infection or cough variant asthma Capsule；Or often mix thick paste with auxiliary material with granule, it pelletizes, dries and be distributed into bag, that is, can be prepared into treatment viral infection The granule of disease or cough variant asthma；Or often mix thick paste with auxiliary material with oral solution, it boils, is diluted with water, stand, Filtering, mixing are distributed into bottle, that is, can be prepared into the oral solution for the treatment of disease of viral infection or cough variant asthma；Or it will be thick Sucrose, corrigent, preservative is added in cream, boils, is diluted with water to 1000ml, stands, and filters, and mixes, and packing is to get treatment disease The syrup of malicious infectious diseases or cough variant asthma, wherein the sucrose weight > 450g.

If also in conjunction with bulk pharmaceutical chemicals great burdock achene or/and tussilago, preparation method are as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, radix bupleuri or/and cicada slough, wood Butterfly or/and myrobalan, schizonepeta or/and Chinese ephedra, PERICARPIUM TRICHOSANTHIS or/and dark plum, great burdock achene or/and tussilago.Add water to cook merging filter Liquid, concentration, cooling add ethyl alcohol to make alcohol content 20-80% (V/V), recycle ethyl alcohol, supernatant is made to be condensed into thick paste, spare.It will system Standby thick paste is added capsule and often uses auxiliary material, and dry, crushing is packed into capsule, that is, can be prepared into treatment disease of viral infection or cough It coughs the capsule of variant asthma；Or often mix thick paste with auxiliary material with granule, it pelletizes, dries and be distributed into bag, can prepare At treatment disease of viral infection or the granule of cough variant asthma；Or often mix thick paste with auxiliary material with oral solution, it boils Boiling, is diluted with water, and stands, and filtering, mixing is distributed into bottle, that is, can be prepared into treatment disease of viral infection or cough anomaly is roared The oral solution of asthma；Or sucrose, corrigent, preservative is added in thick paste, it boils, is diluted with water to 1000ml, stand, filter, mix It is even, the syrup to get treatment disease of viral infection or cough variant asthma is dispensed, wherein the sucrose weight > 450g.

If also in conjunction with bulk pharmaceutical chemicals cordate houttuynia or/and Cortex Magnoliae Officinalis, preparation method are as follows:

Take bulk pharmaceutical chemicals perilla leaf, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, radix bupleuri or/and cicada slough, wood Butterfly or/and myrobalan, schizonepeta or/and Chinese ephedra, PERICARPIUM TRICHOSANTHIS or/and dark plum, great burdock achene or/and tussilago, cordate houttuynia or/and thickness Piao.Merging filtrate, concentration, cooling are added water to cook, ethyl alcohol is added to make alcohol content 20-80% (V/V), ethyl alcohol is recycled, keeps supernatant dense Shorten thick paste into, it is spare.Capsule is added in the thick paste of preparation and often uses auxiliary material, dry, crushing is packed into capsule, that is, can be prepared into treatment The capsule of disease of viral infection or cough variant asthma；Or thick paste is often mixed with auxiliary material with granule, pelletize, it is dry and It is distributed into bag, that is, can be prepared into the granule for the treatment of disease of viral infection or cough variant asthma；Or it by thick paste and takes orally Liquid is often mixed with auxiliary material, is boiled, and is diluted with water, and is stood, and filtering, mixing is distributed into bottle, that is, can be prepared into treatment viral infection The oral solution of disease or cough variant asthma；Or sucrose, corrigent, preservative is added in thick paste, it boils, is diluted with water to 1000ml is stood, and is filtered, and is mixed, and the syrup to get treatment disease of viral infection or cough variant asthma is dispensed, wherein The sucrose weight > 450g.

The traditional chinese medicine composition of the invention can be prepared into dosage form described in any pharmacy: capsule, oral solution, particle Agent, syrup, tablet, effervescence granular, dripping pill, the water-bindered pill, condensed pill, soft capsule, aerosol, spray, gargarisma；The tablet is Oral disintegrating tablet, effervescent tablet.

Medicament selection perilla leaf of the present invention, aster, almond, perilla seed, rhizoma pinellinae praeparata, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae carry out group It closes.Make each efficacy of drugs generate synergistic effect these pharmaceutical compositions, so as to effectively treat disease of viral infection or Cough variant asthma.Fang Zhong: perilla leaf, property is pungent, and tepor is nontoxic, and converge to the spleen channel, lung channel two pass through, and " drugization justice " meaning is hair The object of life, pungent-warm can dissipate, gas Bao Nengtong, and taste is thin to be given vent to, and special expelling pathogenic factors from muscles and skin is delivered, wind typhoid fever of curing the wound and malaria from the beginning of, exogenous disease cholera, Hygropyretic beriberi, all category table diseases, puts the key medicine of perverse trend outlet；Aster: " materia medica ": " aster, it is soft and moist to have a surplus, though say toil And it is warm, it is non-quick-fried strong comparable, it can specially open that let out lung strongly fragrant, it is inverse to determine cough drop, and a surname is logical to stop up stagnant, and thin lung man qi and blood.All the exterior tightened by pathogenic wind-cold, lung qi are stopped up Plug, cough are choked not well, and syndrome characterized by dyspnea croup and gas fire are burnt bright, and strongly fragrant is pulmonary abscess, cough vomiting of pus and blood, and the dirty all cards of the smelly raw meat of phlegm control it invariably；And it trembles with fear Drink is entrenched, and turbid saliva glue is consolidated such as water bird sound person in larynx, especially suitable；Precisely because temperature embellishes but not dry without heat, fever and chills are all suitable, nothing It is evaded；Both perilla leaf, aster are monarch drug in a prescription, dispelling wind cough-relieving altogether；Almond master enters lung channel, and bitter can drop, and simultaneous thin benefit opens it Property, the function for having promoting the dispersing function of the lung among lung qi concurrently is dropped up to relieving cough and asthma, for the key medicine for controlling cough and asthma, can be used for a variety of cough illness with card compatibility Card；Gas under perilla seed, clear phlegm, moistening lung, wide intestines, it is inverse to control cough, phlegm asthma, the stagnation of the circulation of vital energy, constipation；Rhizoma pinellinae praeparata is eliminating dampness and eliminating phlegm, is used for abundant expectoration cough Asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache；Almond, perilla seed, rhizoma pinellinae praeparata three share, regulating qi-flowing for eliminating phlegm, relieving cough and asthma, altogether For ministerial drug；Radix scutellariae hardship, cold, return lung, stomach, gallbladder, large intestine channel, function heat-clearing and damp-drying drug, purging fire for removing toxin, and be good at removing lung-fire and the part of the body cavity above the diaphragm housing the heart and lungs It is damp and hot, be used for cough with lung heat, abscess of throat, carbuncle sore tumefacting virus etc..Modern pharmacological studies have shown that flavones is the important work in radix scutellariae Property substance, mainly include four kinds of ingredients such as scutelloside, baicalein, wogonin, wogonoside, numerous studies confirm in radix scutellariae Flavones ingredient, which has, the extensive pharmacology such as inhibits activity of pancreatic enzyme, antibacterial, inhibits inflammatory reaction, is antiviral, removing free radical make With；The root bark of white mulberry is sweet in flavor, pungent, cold in nature, return lung, the spleen channel, effect removing heat from lung and relieving asthma, inducing diuresis for removing edema, is used for dyspnea and cough due to lung-heat phlegm, and water drink stops Lung, turgor asthma is anxious, oedema, tinea pedis, difficult urination；Radix scutellariae, the root bark of white mulberry are adjutant, same to almond, tuber of pinellia phase 5, and clearing heat and eliminating phlegm is flat Asthma；Radix Glycyrrhizae is raw to be used, preventing phlegm from forming and stopping coughing, mediation property of medicine, and is made for assistant.All medicine compatibilities play dispelling wind and heat, the function of ventilating the lung and relieving cough altogether.

In order to reach better curative effect, drug of the present invention is also combined with radix bupleuri or/and cicada slough.This is because radix bupleuri and inducing diaphoresis In, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever, for cold, fever, fevers and chills alternate.Cicada slough dispelling wind and heat from the body, relieving sore-throat open sound, use In anemopyretic cold, warm disease is from the beginning of pharyngalgia hoarse voice.

In order to reach better curative effect, drug of the present invention is also combined with Oroxylum indicum or/and myrobalan.This is because Oroxylum indicum is clear Lung relieving sore-throat cures mainly cough with lung heat, sore throat, hoarse voice.Myrobalan is astringeed the lung to stop cough, fall fire relieving sore-throat, is cured mainly the deficiency syndrome of the lung and is breathed with cough, and is coughed long more than, pharynx Pain hoarse voice.

In order to reach better curative effect, drug of the present invention is also combined with schizonepeta or/and Chinese ephedra.This is because schizonepeta wind-dispelling solution Table, promoting eruption disappear sore, and pharmacological property mitigates, no matter chill, wind-heat or the unobvious person of fever and chills, can be widely used.Shennong's Herbal calls Chinese ephedra: " main apoplexy, cold headache, a kind of malaria；Perspiration is delivered, uncharm hot gas, only cough with dyspnea, removes fever and chills, breaks hard accumulation."；Dense Huang Warm profit partially, pungent scattered perspiration mitigate, and enhance moistening lung to arrest cough, with cough-relieving power victory of freeinging lung and relieving asthma, are chiefly used in table disease and have solved, cough of panting It coughs.

In order to reach better curative effect, drug of the present invention is also combined with PERICARPIUM TRICHOSANTHIS or/and dark plum.This is because PERICARPIUM TRICHOSANTHIS is clear Lung resolving sputum, sharp gas relieving stuffiness of the chest by dispersing aggregation of pathogens cure mainly cough with lung heat, chest side of body ruffian pain, abscess of throat.Dark plum astringing lung-QI is used for chronic cough of deficiency lung.

In order to reach better curative effect, drug of the present invention is also combined with great burdock achene or/and tussilago.This is because great burdock achene Dispelling wind and heat from the body, promoting the dispersing function of the lung relieving sore-throat cure mainly anemopyretic cold, warm disease from the beginning of.Tussilago moistening lung to lower qi, preventing phlegm from forming and stopping coughing cure mainly new chronic cough and cough, Asthma.

In order to reach better curative effect, drug of the present invention is also combined with cordate houttuynia or/and Cortex Magnoliae Officinalis.This is because cordate houttuynia taste It is pungent, it is cold, it is distributed in lung channel, can be clearing heat and detoxicating, it is the pulmonary abscess etc. suffered from real heat, heat toxin, damp evil is controlled, modern pharmacology experiment shows This product has the effects that antibacterial, antiviral, raising immunity of organisms.Cortex Magnoliae Officinalis eliminating dampness dissolving phlegm, lower gas removes full cure mainly sputum cough.

In recent years, the etiology and pathogenesis of Chinese medicine, which is studied, carries out exploration all around body ressitance weakened while pathogenic factors prevailing.In terms of the domination of pathogen all around Kindling wind, cold, heat, wet, dry, the six external factors which cause diseases heresy are studied.Inventor takes the lead in proposing that ailment said due to cold or exposure is that cough variant asthma occurs, sends out Main pathogenic in exhibition and evolution process.And evil visitor is in lung, it is the main pathogenesis of this disease that air flue is impaired.Chinese medicine group of the present invention Closing object is to summarize to use in the traditional Chinese medicine treatment disease of viral infection of many years or the clinical practice of cough variant asthma Empirical formula, each component can play respective pharmacological action and play mutual synergistic effect, enhance pharmacological action, match Fang Heli, flavour of a drug refining, the Chinese medicine composition is curative for effect for treating disease of viral infection or cough variant asthma, It has no toxic side effect, dosage form and preparation process are suitble to industrial mass production.

Specific embodiment

The present invention treats the Chinese medicine composition of disease of viral infection or cough variant asthma, including following parts by weight Bulk pharmaceutical chemicals: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, radix scutellariae 3- 20 parts, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae.

For the curative effect reached, drug of the present invention can be combined with bulk pharmaceutical chemicals radix bupleuri or/and cicada slough.To reach better treatment Effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals Oroxylum indicum or/and myrobalan.To reach better curative effect, drug of the present invention is also It can be combined with bulk pharmaceutical chemicals schizonepeta or/and Chinese ephedra.To reach better curative effect, drug of the present invention can also be with bulk pharmaceutical chemicals PERICARPIUM TRICHOSANTHIS Or/and dark plum combines.To reach better curative effect, drug of the present invention can also mutually be tied with bulk pharmaceutical chemicals great burdock achene or/and tussilago It closes.To reach optimal curative effect, drug of the present invention can also be combined with bulk pharmaceutical chemicals cordate houttuynia or/and Cortex Magnoliae Officinalis.

Embodiment 1:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, radix scutellariae 10 Gram, 5 grams of the root bark of white mulberry, 5 grams of Radix Glycyrrhizae, totally 70 grams of above 8 herbal medicine, add water to cook merging filtrate, concentration, cooling, ethyl alcohol added to make to contain Alcohol amount is 20-80%, recycles ethyl alcohol, supernatant is made to be condensed into thick paste, spare.Beta-cyclodextrin is added, dissolves by heating, stirring, filter It crosses, be spray-dried 180 DEG C of hot-air inlet air temperature, 80 DEG C of leaving air temp, flavoring agent is added in spray powder, mixes, material is at 40 DEG C At a temperature of dry granulation, whole grain, be distributed into bag to get the present invention treatment disease of viral infection or cough variant asthma Granula.

Embodiment 2:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 5 grams of white skin, 5 grams of Radix Glycyrrhizae, add water to cook merging filtrate, concentration, cooling, ethyl alcohol are added to make alcohol content by totally 70 grams of above 8 herbal medicine 20-80% recycles ethyl alcohol, supernatant is made to be condensed into thick paste, spare.95% ethyl alcohol of 2 times of cream weights is added in thick paste, sufficiently stirs It mixes, stands 24~48h at room temperature, take supernatant, with 65% ethanol washing 1~2 time, cleaning solution merges sediment with supernatant, If any alcohol extract, also merge with supernatant, after filtering is clear and bright, enters to be concentrated under reduced pressure tank or alcohol distillation column recycling ethyl alcohol until medical fluid No alcohol taste is stopped.Medical fluid adds distilled water to dilute, and is heated to 100 DEG C, makes coacervation of colloid, adjusts pH4.5~5.0, then 0~4 DEG C of low temperature cold Hiding for 24 hours, makes the colloidal precipitation of cohesion, and then, suitable corrigent and preservative is added to clear and bright in filtration, after standing, then filters Clear and bright, low-temp storage does last purification filtering before filling, filtrate set detected under lamp inspection instrument it is clear and bright after, upper mechanical irrigation is encapsulated in straight tube In easy open cover nutrition bottle, built-in 10ml ± 4% of every oral liquid bottle becomes to get present invention treatment disease of viral infection or cough The oral solution of special-shaped asthma.

Embodiment 3:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry Totally 80 grams of above 9 herbal medicine, particle then is made by method described in embodiment 1 in 5 grams of white skin, 5 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri Agent.

Embodiment 4:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 5 grams of white skin, 5 grams of Radix Glycyrrhizae, 10 grams of cicada slough, are then made by method described in embodiment 2 oral totally by 80 grams of above 9 herbal medicine Liquid.

Embodiment 5:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 5 grams of white skin, 5 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of Oroxylum indicum, totally 90 grams of above 10 herbal medicine, then by described in embodiment 1 Granule is made in method.

Embodiment 6:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, radix scutellariae 10 Gram, 5 grams of the root bark of white mulberry, 5 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of myrobalan, totally 90 grams of above 10 herbal medicine, then by described in embodiment 2 Method oral solution is made.

Embodiment 7:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 5 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, Sang Bai 10 grams of skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of Oroxylum indicum, 10 grams of schizonepeta, then press embodiment party by totally 105 grams of above 11 herbal medicine Granule is made in method described in formula 1.

Embodiment 8:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of myrobalan, 5 grams of Chinese ephedra, then press embodiment party by totally 105 grams of above 11 herbal medicine Oral solution is made in method described in formula 2.

Embodiment 9:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of Oroxylum indicum, 10 grams of schizonepeta, 10 grams of PERICARPIUM TRICHOSANTHIS, above 12 herbal medicine totally 120 Gram, granule then is made by method described in embodiment 1.

Embodiment 10:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of myrobalan, 5 grams of Chinese ephedra, 10 grams of dark plum, totally 115 grams of above 12 herbal medicine, then Oral solution is made by method described in embodiment 2.

Embodiment 11:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of Oroxylum indicum, 10 grams of schizonepeta, 10 grams of PERICARPIUM TRICHOSANTHIS, 10 grams of great burdock achene, above 13 taste Totally 130 grams of drug, granule then is made by method described in embodiment 1.

Embodiment 12:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of myrobalan, 5 grams of Chinese ephedra, 10 grams of dark plum, 10 grams of tussilago, above 13 herbal medicine Totally 125 grams, oral solution then is made by method described in embodiment 2.

Embodiment 13:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of Oroxylum indicum, 10 grams of schizonepeta, 10 grams of PERICARPIUM TRICHOSANTHIS, 10 grams of great burdock achene, cordate houttuynia 15 Gram, totally 145 grams of above 14 herbal medicine, granule then is made by method described in embodiment 1.

Embodiment 14:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of myrobalan, 5 grams of Chinese ephedra, 10 grams of dark plum, 10 grams of tussilago, 10 grams of Cortex Magnoliae Officinalis, it is above Totally 135 grams of 14 herbal medicines, oral solution then is made by method described in embodiment 2.

Embodiment 15:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of myrobalan, 10 grams of schizonepeta, 10 grams of dark plum, 10 grams of great burdock achene, 10 grams of Cortex Magnoliae Officinalis, with Totally 140 grams of upper 14 herbal medicine, granule then is made by method described in embodiment 1.

Embodiment 16:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 5 grams of rhizoma pinellinae praeparata, 15 grams of radix scutellariae, Sang Bai 20 grams of skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of cicada slough, 20 grams of Oroxylum indicum, 10 grams of myrobalan, 10 grams of schizonepeta, 5 grams of Herba ephedrae, it is above Totally 155 grams of 14 herbal medicines, oral solution then is made by method described in embodiment 2.

Embodiment 17:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of Oroxylum indicum, 5 grams of Chinese ephedra, 10 grams of PERICARPIUM TRICHOSANTHIS, 10 grams of tussilago, cordate houttuynia 15 Gram, totally 140 grams of above 14 herbal medicine, granule then is made by method described in embodiment 1.

Embodiment 18:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of radix bupleuri, 10 grams of Oroxylum indicum, 10 grams of schizonepeta, 10 grams of dark plum, 10 grams of tussilago, 10 grams of Cortex Magnoliae Officinalis, Totally 140 grams of above 14 herbal medicine, oral solution then is made by method described in embodiment 2.

Embodiment 19:

Weigh 10 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 10 grams of radix scutellariae, mulberry 10 grams of white skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 10 grams of myrobalan, 5 grams of Chinese ephedra, 10 grams of PERICARPIUM TRICHOSANTHIS, 10 grams of great burdock achene, 15 grams of cordate houttuynia, Totally 140 grams of above 14 herbal medicine, granule then is made by method described in embodiment 1.

Embodiment 20:

Weigh 5 grams of bulk pharmaceutical chemicals perilla leaf, 10 grams of aster, 10 grams of almond, 10 grams of perilla seed, 10 grams of rhizoma pinellinae praeparata, 20 grams of radix scutellariae, Sang Bai 20 grams of skin, 10 grams of Radix Glycyrrhizae, 10 grams of cicada slough, 20 grams of Oroxylum indicum, 10 grams of schizonepeta, 5 grams of Chinese ephedra, totally 140 grams of above 12 herbal medicine, then Oral solution is made by method described in embodiment 2.

Test example 1: the Germicidal efficacy of Chinese medicine composition anti-adenovirus in vitro

Test philosophy: with human embryonic kidney cells (HEK-293) for virus host, measurement sample inhibits adenovirus to cause human embryonic kidney cells Lesion degree.

1. test material:

1.1 Strain: adenovirus.

1.2 sample treatments: thick paste made from Example 1,5,7,9,16 is dissolved in water and is respectively prepared 1000mg/ml's Solution bottling is spare；3000rpm centrifugation takes supernatant after twenty minutes, with 50% sodium citrate tune pH7.2~7.6, is poured into nothing In bacterium test tube, 121 DEG C, 15-20 minutes high pressure sterilizations take out in 4 DEG C of refrigerators of postposition and save backup；Solution example is trained when experiment Nutrient solution 1:10 dilution starts, and makees 2 times of dilutions, totally 8 dilutions.

1.3 positive control drugs: Ribavirin (RBV) Jiangxi Huiren Pharmaceutical Co., Ltd production.

2. test method

2.1 by Human embryo epithelial cell (2~4) × 10⁵0.1ml is inoculated into 96 hole micro plastics culture plates, every 100 μ l 37 of hole DEG C, 5%CO₂Culture 1~2 day, grows into cell monolayer.Cell growth medium is MEM 100ml, containing newborn or fetal calf serum 10%, 3% glutamine 1%, penicillin and streptomysin each 100U/ml, NaHCO35%；When cell grows up to single layer, abandoning growth Liquid needs to be washed cell two times with PBS the or Hanks liquid of pre-temperature before virus inoculation.

2.2 drain, and add 100 10~100TCID of μ l₅₀Viral suspension infection cell, 37 DEG C of 1~2h of absorption abandon virus liquid, Again plus 100 μ l of the maintaining liquid containing various concentration untested compound, each 2~3 hole of concentration, 37 DEG C of 5%CO₂Incubation continues Culture.If normal cell controls, drug toxicity control, virus control, Ribavirin (RBV) positive control and virus TCID₅₀Drop It is fixed.

2.3 check and record daily cytopathy under inverted microscope, and (< 25% is plus sige, 25_~50% is two Plus sige, 50_~75% is three plus siges, 75_~100% is four plus siges), until virus control wells (untested compound is not added) occurs 3_~It is experimental endpoints when the cytopathy of 4 plus siges.Each hole cytopathy degree is recorded, every group of average cell lesion journey is calculated Degree is calculated with Reed and Muench method and compound concentration, that is, half of 50% cytopathy is inhibited to press down compared with virus control group Concentration (IC processed₅₀)。

2.4, simultaneously by 2.3 criterion calculation drug to the toxicity of cell, are calculated with Reed and Muench method and occur 50% carefully The compound concentration of born of the same parents' lesion, that is, half toxic concentration (TD₅₀)。

2.5TD₅₀/IC₅₀To select index (SI).

3. experimental result:

Test example 2: the Germicidal efficacy of Chinese medicine composition anti-influenza B virus in vitro

Test philosophy: with MDCK (dog kidney cells) for virus host, measurement sample inhibits influenza B virus to cause mdck cell Lesion degree.

1. test material:

1.1 Strain: influenza B virus.

1.2 sample treatments: thick paste made from Example 2,6,8,10,16 is dissolved in water and 1000mg/ml is respectively prepared Solution bottling it is spare；3000rpm centrifugation takes supernatant after twenty minutes, with 50% sodium citrate tune pH7.2~7.6, is poured into In sterile test tube, 121 DEG C, 15-20 minutes high pressure sterilizations take out in 4 DEG C of refrigerators of postposition and save backup；Solution example when experiment Started with culture solution 1:10 dilution, makees 2 times of dilutions, totally 8 dilutions.

2. test method: 96 well culture plate of Human embryo epithelial cell kind infects influenza B virus (sense respectively after 24 hours Dye amount be 100 TCID50), adsorb 2 hours, abandon virus liquid, by the above dilution be added sample, while set cell control well with Virus control wells, 24 hours observation cytopathy degree (CPE), the half for calculating separately sample with Reed-Muench method are effective Concentration (IC₅₀), and calculate medicament selection index (SI).

3. experimental result:

Test example: traditional Chinese medicine composition for treating cough variant asthma clinical observation

1. data and method

1.1 clinical data

1.1.1 this group of case is the Function in Cough Variant Asthma Patients made a definite diagnosis in January, 2017 in January, 2014, age 18-65 In year, meet following diagnostic criteria, 150 patients are randomly divided into Chinese medicine group (Chinese medicine composition) 75, Western medicine group (montelukast Sodium, Theo-Dur) 75.Chinese medicine group 75 be assigned randomly to 2,5,7,13,16 groups of embodiment example (abbreviation Chinese medicine group A, B, C, D, E) it is 15 each, Western medicine group 75 be randomly divided into five groups (abbreviation Western medicine group A, B, C, D, E) it is 15 each, match by same English alphabet To comparing, each group is distributed upper not statistically significant (P > 0.05) in gender, age, the course of disease and the state of an illness.

1.1.2 diagnostic criteria

1.1.2.1 Western medicine diagnostic criteria

Chronic cough (more than 8 weeks) is often accompanied by apparent night irritable cough, no phlegm or a small amount of white dilute phlegm；

The bronchial provocation test positive or maximum expiratory flow volume (PEF) diurnal variation rate > 20% or Bronchodilation Test sun Property；

Antibiotic and pectoral are invalid, effective with bronchodilator, glucocorticoid treatment；

Physical examination is without obvious positive sign；Rabat is normal, and pulmonary ventilation function is normal (non-coughing fit phase), and ENT dept. checks not It notes abnormalities；

Exclude chronic cough caused by other reasons；

1.2 treatment method

Chinese medicine group gives Chinese medicinal composition granules or oral solution, takes orally, twice daily；Western medicine group 10 milli of Montelukast Sodium piece Gram once a day, 100 milligrams of Theo-Dur twice daily, takes orally, the Chinese and Western treatment group course for the treatment of is 10 days.

2. observation index

Chinese medicine group, Western medicine group Function in Cough Variant Asthma Patients carry out curative effect, adverse reaction comparison between group after treating 10 days；And it carries out Effect follow-up after treatment in 2 months；

3. efficacy assessment standard

Effective: patient's cough symptom disappears after treatment, and auscultation of lung is normal, and follow-up 2 months without recurrence；

Effective: patient's cough symptom is alleviated after treatment, occasionally has coughing fit when meeting dust, cold air stimulation and movement；It is invalid: to control Patient's symptom is without improvement after treatment.

4. result

Cough variant asthma is treated with the Chinese medicine composition (Chinese medicine group A) of embodiment of the present invention example 2, the results showed that in Medicine group A overall clinical efficacy rate 80%；Western medicine group A clinical improvements total effective rate 53.33%；Chinese medicine group A and Western medicine A group comparing difference Statistically significant (P < 0.05).Clinical effectiveness prompt: 2 traditional Chinese medicine composition for treating of embodiment of the present invention example cough anomaly Asthma satisfactory effect, Chinese medicine group is superior to Western medicine group in terms of alleviating clinical symptoms and total effective rate.

Cough variant asthma is treated with the Chinese medicine composition (Chinese medicine group B) of embodiment of the present invention example 5, as a result table It is bright: Chinese medicine group B overall clinical efficacy rate 86.67%；Western medicine group B clinical improvements total effective rate 60%；Chinese medicine group B and Western medicine group B ratio (P < 0.05) statistically significant compared with difference.Clinical effectiveness prompt: 5 traditional Chinese medicine composition for treating of embodiment of the present invention example cough Variant asthma satisfactory effect, Chinese medicine group is superior to Western medicine group in terms of alleviating clinical symptoms and total effective rate.

Cough variant asthma is treated with the Chinese medicine composition (Chinese medicine group C) of embodiment of the present invention example 7, as a result table It is bright: Chinese medicine group C overall clinical efficacy rate 86.67%；Western medicine group C clinical improvements total effective rate 53.33%；Chinese medicine group C and Western medicine group C Comparing difference is statistically significant (P < 0.05).Clinical effectiveness prompt: 8 traditional Chinese medicine composition for treating cough of embodiment of the present invention example It coughs variant asthma satisfactory effect, Chinese medicine group is superior to Western medicine group in terms of alleviating clinical symptoms and total effective rate.

Cough variant asthma is treated with the Chinese medicine composition (Chinese medicine group D) of embodiment of the present invention example 13, as a result table It is bright: Chinese medicine group D clinical improvements total effective rate 93.33%；Western medicine group D clinical improvements total effective rate 66.67%；Chinese medicine group D and west Medicine group D comparing difference is statistically significant (P < 0.05).Clinical effectiveness prompt: 13 Chinese medicine composition of embodiment of the present invention example Cough variant asthma satisfactory effect is treated, Chinese medicine group is superior to Western medicine group in terms of alleviating clinical symptoms and total effective rate.

Cough variant asthma, knot are treated with the Chinese medicine composition (Chinese medicine group E) of embodiment of the present invention example 16

Fruit shows: Chinese medicine group E clinical improvements total effective rate 93.33%；Western medicine group E clinical improvements total effective rate 60%；Chinese medicine group E It is statistically significant (P < 0.05) with Western medicine group E comparing difference.Clinical effectiveness prompt: 16 Chinese medicine group of embodiment of the present invention example It closes object and treats cough variant asthma satisfactory effect, Chinese medicine group is superior to Western medicine in terms of alleviating clinical symptoms and total effective rate Group.

Western medicine group patient is a small number of during treatment to there is the slight adverse reaction performance such as nausea, insomnia, and Chinese medicine group patient is not There is adverse reaction.

The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention Protection scope.

Claims

1. a kind of Chinese medicine composition for treating disease of viral infection or cough variant asthma, it is characterised in that: including following The bulk pharmaceutical chemicals of parts by weight form: 1-30 parts of perilla leaf, 1-30 parts of aster, 1-30 parts of almond, 1-30 parts of perilla seed, rhizoma pinellinae praeparata 1- 30 parts, 1-30 parts of radix scutellariae, 1-30 parts of the root bark of white mulberry, 1-20 parts of Radix Glycyrrhizae.

2. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein The dosage of bulk pharmaceutical chemicals is: 3-20 parts of perilla leaf, 3-20 parts of aster, 3-20 parts of almond, 3-20 parts of perilla seed, 3-20 parts of rhizoma pinellinae praeparata, 3-20 parts of radix scutellariae, 3-20 parts of the root bark of white mulberry, 3-15 parts of Radix Glycyrrhizae.

3. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein Bulk pharmaceutical chemicals are also: 3-20 parts of radix bupleuri or/and 3-20 parts of cicada slough.

4. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein Bulk pharmaceutical chemicals are also: 3-20 parts of Oroxylum indicum or/and 3-20 parts of myrobalan.

5. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein Bulk pharmaceutical chemicals are also: 3-20 parts of schizonepeta or/and 3-20 parts of Chinese ephedra.

6. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein Bulk pharmaceutical chemicals are also: 3-20 parts of PERICARPIUM TRICHOSANTHIS or/and 3-20 parts of dark plum.

7. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein Bulk pharmaceutical chemicals are also: 3-20 parts of great burdock achene or/and 3-20 parts of tussilago.

8. the Chinese medicine composition for the treatment of disease of viral infection according to claim 1 or cough variant asthma, wherein There are also 5-25 parts of cordate houttuynia or/and 3-20 parts of Cortex Magnoliae Officinalis for bulk pharmaceutical chemicals.

9. the Chinese medicine group of described in any item treatment diseases of viral infection or cough variant asthma according to claim 1~8 Close object, it is characterised in that: the dosage form of the composition are as follows: capsule, oral solution, granular pattern, syrup, tablet, dripping pill, the water-bindered pill, Condensed pill, soft capsule, aerosol, spray, gargarisma；The tablet is oral disintegrating tablet, effervescent tablet.

10. the preparation method of the Chinese medicine composition of disease of viral infection or cough variant asthma is treated, comprising steps of

A the described in any item bulk pharmaceutical chemicals of claim 1-8) are taken, merging filtrate, concentration, cooling is added water to cook, ethyl alcohol is added to make alcohol-containing The percentage by volume of 20-80% is measured, ethyl alcohol is recycled, supernatant is made to be condensed into thick paste, it is spare；

B capsule) is added in the thick paste of preparation and often uses auxiliary material, dry, crushing is packed into capsule, that is, is prepared into treatment viral infection The capsule of disease or cough variant asthma；Or often mix thick paste with auxiliary material with granule, it pelletizes, dries and be distributed into bag, It is prepared into the granule for the treatment of disease of viral infection or cough variant asthma；Or thick paste is often mixed with auxiliary material with oral solution It closes, boils, be diluted with water, stand, filtering, mixing is distributed into bottle, that is, is prepared into treatment disease of viral infection or cough variation The oral solution of type asthma；Or sucrose, corrigent, preservative is added in thick paste, it boils, is diluted with water, stand, filter, mix, point The syrup to get treatment disease of viral infection or cough variant asthma is filled, wherein the sucrose weight > 450g；Or it will system Standby thick paste often mixes with auxiliary material with tablet, tabletting, that is, is prepared into treatment disease of viral infection or cough variant asthma Tablet.

11. the preparation for the treatment of disease of viral infection or the Chinese medicine composition of cough variant asthma as claimed in claim 10 Method, it is characterized in that: the corrigent is stevioside, saccharin sodium, acesulfame-K, glycyrrhizin, thiacyclohexane sulfamic acid, asparagus fern acyl One of amine, alcohol sugar, radix asparagi sweet extract, menthol, various essence and various fruity material are several, and dosage is 0.1 ~ 10%；Institute State the methyl hydroxybenzoate class of sorbic acid and its k-na salt or dosage < 0.05% that preservative is dosage < 0.3%；The packing makes Packaging material is vial, plastic bottle.

12. the Chinese medicine group of described in any item treatment diseases of viral infection or cough variant asthma according to claim 1~8 Close object, it is characterised in that: it is treating or preventing adenovirus infection disease or influenza B virus infectious diseases or cough Application in variant asthma.