CN103705890A - Pharmaceutical composition with function of removing heat from lung to relieve cough - Google Patents

Pharmaceutical composition with function of removing heat from lung to relieve cough Download PDF

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Publication number
CN103705890A
CN103705890A CN201310738384.2A CN201310738384A CN103705890A CN 103705890 A CN103705890 A CN 103705890A CN 201310738384 A CN201310738384 A CN 201310738384A CN 103705890 A CN103705890 A CN 103705890A
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parts
cough
lung
bulbus fritillariae
gypsum fibrosum
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CN201310738384.2A
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邓权艳
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GUANGXI JINYE PHARMACEUTICAL CO Ltd
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GUANGXI JINYE PHARMACEUTICAL CO Ltd
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Abstract

The invention discloses a medicament with a function of removing heat from lung to relieve cough. The medicament is prepared from the following raw materials in parts by weight: 60-100 parts ephedra, 140-180 parts of gypsum, 120-160 parts of semen armeniacae amarae, 30-50 parts of sessile stemona root, 30-50 parts of tussilago farfara, 30-50 parts of thunberg fritillary bulb, 60-100 parts of white mulberry root bark, 60-100 parts of cordate houttuynia, 60-100 parts of Chinese mahonia stem, 18-30 parts of pericarpium citri reticulatae, 30-50 parts of liquorice, 60-120 parts of fresh momordica grosvenori and 5-15 parts of fresh ginger. The medicament is clinically used for dispelling wind and opening the inhibited lung-energy, relieving cough and reducing sputum, and is suitable for improving symptoms of cough, expectoration and the like.

Description

A kind of pharmaceutical composition with clearing away lung-heat to relieve cough effect
Technical field
The present invention relates to a kind of medicine with clearing away lung-heat to relieve cough effect, the pharmaceutical composition with clearing away lung-heat to relieve cough effect that the Chinese herbal medicine of take is specifically prepared from as preparation of raw material.
Background technology
Cough is a kind of important defense mechanism of human body, stimulate, or harmful gas sucks, or foreign body is while being accidentally strayed into air flue, just causes cough, therefore cough is a kind of guarding reflex when respiratory mucosa is subject to too much secretions.Cough can significantly increase intrathoracic pressure and expiration speed and hemodynamics is exerted an influence; it is a kind of guarding reflex; can effectively remove the respiratory tract factor; or when there is severe arrhythmia, assist to maintain patient and realize even conversion; play the effect of spontaneity " cardio-pulmonary resuscitation "; but it is also the clinical symptoms that numerous disease occurs simultaneously, is one of modal disease main suit.Frequent and long-term cough can make to infect and spread in respiratory tract; Impact sleep, consumes one's strength; Make to contain pathogenic former secretions and send out, cause pathophoresis; Bring out the complication of a plurality of systems such as cardiovascular, nerve, digestive tract, breathing.Therefore, the diagnosis and treatment of cough have been subject to great attention in the world.
Treatment for cough, Chinese medicine has the features such as integration, personalization and body constitution, side's medicine used, except using modern pharmacological research to have the heat-clearing and toxic substances removing medicine of antibacterial, antivirus action, is mostly to note contacting of certain dirty certain internal organs and cough, dialectical dispenser, take and get rid of evils as routine treatment, medication is warm-dryness syndrome or cold and cool and biased and do the doctor trained in Western medicine comparison of contraria with antibiotic too not, and to the treatment of cough, Chinese medicine all exists its unique advantage at aspects such as theory, principle-method-recipe-medicineses.Existing research data show the traditional Chinese medical science to the treatment of cough especially to intractable cough, chronic cough and through doctor trained in Western medicine with the invalid patient of antibiotic therapy, still can obtain good curative effect, Chinese medicine is coughed and is had its unique curative effect considering the feature treatment of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to its Overall View.
Chinese medicine with its safely and efficiently advantage win more and more patients' favor.Stone Fructus Pruni productive cough sheet (the accurate word B20020463 of traditional Chinese medicines) is more ripe in the market Chinese patent medicine, also be the product that applicant researches and develops and goes on the market in early days, take Herba Ephedrae, Gypsum Fibrosum, Semen Armeniacae Amarum, the Radix Stemonae, Flos Farfarae, Bulbus Fritillariae Thunbergii, Cortex Mori, Herba Houttuyniae, Caulis Mahoniae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae is raw material, be applicable to improve the symptoms such as cough, expectorant Huang, have good curative effect.But this medicine is when some anemopyretic cough for the treatment of, and therapeutic effect is not too desirable.Particularly in south early spring, wet weather, temperature neglect to rise and suddenly to fall, and raw and sultryly alternately causes the wind-heat invading the lung cough that flu causes, and effect is unequal to ideal.For this reason, applicant improves existing formula, develops new product, and can effectively overcome some intrinsic shortcomings of existing formula body, have advantages of that quality is higher, curative effect is more stable and features good taste, simple, safety, reasonable price, bring more economic benefit and social benefit.
Summary of the invention
The deficiency such as the technical problem to be solved in the present invention is undesirable for the existing cough suppressing medicine clearing away lung-heat to relieve cough effect with herbal prescription or curative effect is unstable, provides a kind of more effective pharmaceutical composition with clearing away lung-heat to relieve cough effect.
In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, by the raw material of following weight parts, is made:
Herba Ephedrae 60-100 part, Gypsum Fibrosum 140-180 part, Semen Armeniacae Amarum 120-160 part, Radix Stemonae 30-50 part, Flos Farfarae 30-50 part, Bulbus Fritillariae Thunbergii 30-50 part, Cortex Mori 60-100 part, Herba Houttuyniae 60-100 part, Caulis Mahoniae 60-100 part, Pericarpium Citri Reticulatae 18-30 part, Radix Glycyrrhizae 30-50 part, fresh Fructus Momordicae 60-120 part, Rhizoma Zingiberis Recens 5-15 part.
Be preferably: Herba Ephedrae 70-90 part, Gypsum Fibrosum 150-170 part, Semen Armeniacae Amarum 130-150 part, Radix Stemonae 35-45 part, Flos Farfarae 35-45 part, Bulbus Fritillariae Thunbergii 35-45 part, Cortex Mori 75-85 part, Herba Houttuyniae 75-85 part, Caulis Mahoniae 75-85 part, Pericarpium Citri Reticulatae 21-27 part, Radix Glycyrrhizae 35-45 part, fresh Fructus Momordicae 72-108 part, Rhizoma Zingiberis Recens 8-12 part.
Optimum is: 80 parts, Herba Ephedrae, 160 parts, Gypsum Fibrosum, 140 parts of Semen Armeniacae Amarums, 40 parts of the Radixs Stemonae, 40 parts of Flos Farfaraees, 40 parts of Bulbus Fritillariae Thunbergiis, 80 parts of Cortex Mori, 80 parts of Herba Houttuyniae, 80 parts of Caulis Mahoniaes, 24 parts of Pericarpium Citri Reticulataes, 40 parts, Radix Glycyrrhizae, 90 parts of fresh Fructus Momordicaes, 10 parts, Rhizoma Zingiberis Recens.
The above-mentioned pharmaceutical composition with clearing away lung-heat to relieve cough effect can adopt existing conventional method to be prepared, and is preferably prepared by the following method: by proportional quantity, take above each raw material, get the Bulbus Fritillariae Thunbergii of half, be ground into fine powder, and standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, add for the first time 7-8 times of water gaging, decoct 1.5-2 hour, add for the second time 6-8 times of water gaging, decoct 1-1.5 hour, collecting decoction, filters, when filtrate is concentrated into relative density and is 1.30-1.35(70 ℃, survey) clear paste, add Bulbus Fritillariae Thunbergii fine powder, add cane sugar powder approximately appropriate, granulation.
Preferably be prepared by the following method: by proportional quantity, take above each raw material, the Bulbus Fritillariae Thunbergii of getting half is ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder, and all the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water twice, add for the first time 7-8 times of water gaging, decoct 1.5-2 hour, add for the second time 6-8 times of water gaging, decoct 1-1.5 hour, collecting decoction, filters, filtrate is concentrated into the thick paste that relative density is 1.38-1.42 (85 ℃ time survey), add Bulbus Fritillariae Thunbergii fine powder and starch to mix in right amount, dry, pulverize into fine powder, incapsulate, obtain.
The dosage form of medicine of the present invention can be the medically acceptable dosage forms such as granule, capsule, tablet, oral liquid, and their preparation method, supplementary product consumption are undertaken by existing common process.
In pharmaceutical composition prescription of the present invention:
Herba Ephedrae is HANYAO or claims the wind-cold-dispersing medicinal in Chinese medicine, ancient times is called imperial sand, inferior phase, include the plant of three kinds of Ephedras: Ephedra sinica (Ephedra sinica), ephedra equisetina (Ephedra equisetina) and epheday intermedia (Ephedra intermedia), main diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Relieving the exterior syndrome by diaphoresis and inducing diuresis to remove edema power are strong, are used for chill exterior syndrome, uncomfortable in chest breathing with cough, edema due to wind pathogen edema, rheumatic arthralgia, carbuncle of yin nature, sucutaneous nodule.
The Gypsum Fibrosum lung that clears away heart-fire, controls agitation, lets out hot and suffocatingly, stops dry yearningly, controls fanatically, and cough caused by pathogenic fire, receives febrile perspiration, and heat-phlegm disappears.
Semen Armeniacae Amarum, expelling phlegm for arresting cough, relievings asthma, intestine moistening, the therapeutic method to keep the adverse QI flowing downwards is opened numbness.
The Radix Stemonae belongs to expectorant cough suppressant and anti-asthmatic class Chinese medicine, sweet in the mouth, and hardship, property is flat, returns lung meridian.The effect that has nourishing the lung to arrest cough, is applied to treat new and old cough, pertussis, the cards such as lung impairment and cough.
Flos Farfarae is the alabastrum of Compositae coltsfoot, and property and flavor of peppery and warm, has nourishing the lung to keep the adverse QI downward, the effect of the antitussive that reduces phlegm.In < < herbal classic > >, record: to " pathogenic fluid-retention of cold bundle lung meridian is breathed heavily, coughs the most suitable ".Though abnormal smells from the patient is warm, embellish but not dry, warm heresy, strongly fragrant in lung meridian and must not catharsis person, also can control it.Therefore the cough of Exogenous and internal injuries, cold and heat and asthenia and sthenia, all can apply.Particularly chronic cough of deficiency lung is more than, the most applicable.
The effect of Bulbus Fritillariae Thunbergii and effect are removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating, control wind heat or phlegm-heat cough, lung abscess vomiting pus.
Cortex Mori is sweet cold, eliminating pathogen from the lung for relieving asthma, and inducing diuresis to remove edema, treatment pneumonia is coughed and is gargled.
Herba Houttuyniae acrid in the mouth, cold nature, returns lung meridian, and function cures mainly: have heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus effect is used for the treatment of cough due to lung-heat, and is treatment phlegm-heat obstructing in the lung, sends out as lung abscess, coughs the key medicine of vomiting bloody pus.
Caulis Mahoniae, heat clearing away, dampness, removing toxic substances, main cough due to lung-heat.
Fructus Momordicae, is described as " angle fruit " by people, particularly fresh fruit nutritive value is very high, contains abundant vitamin C (containing 400 milligrams-500 milligrams in every 100 grams of fresh fruits) and glucoside, fructose, glucose, protein, lipid etc.Fructus Momordicae is the distinctive precious cucurbitaceous plant of China, have the title of the good fruit of good medicine, and in north, osmanthus, wide geographic area has rich in natural resources.In fresh fruit, contain abundant glucose, fructose and multivitamin etc., of many uses.Function cures mainly: clearing heat and moistening lung, and cough-relieving, sore-throat relieving, laxation relieving constipation, for lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.It has the pharmacological action of cough-relieving, is mainly that wherein contained PEARLITOL 25C and triterpenoid saponin has antitussive action.Fructus Momordicae is used to treatment cough or as food additive among the people always.
Rhizoma Zingiberis Recens is also a kind of food with medical value, and Rhizoma Zingiberis Recens has the effect of lung qi dispersing cough-relieving, has again the effect of the cold-damp dispelled.
Pharmaceutical composition of the present invention, reasonable recipe, with Herba Ephedrae, Gypsum Fibrosum depressed lung-energy dispersing; Semen Armeniacae Amarum, Flos Farfarae, Radix Stemonae nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing; Herba Houttuyniae heat-clearing and toxic substances removing, antiphlogistic antibacterial; Bulbus Fritillariae Thunbergii, Caulis Mahoniae, Cortex Mori removing heat-phlegm purte the white and reach the effect for the treatment of both the principal and secondary aspects of a disease; Add fresh Fructus Momordicae, Rhizoma Zingiberis Recens, inventor finds by test again, and compositions of the present invention has good curative effect in the common anemopyretic cough for the treatment of Spring In Southern.In the present invention formula, added that the action effect of cough-relieving to be compared to the formula or the single dose that do not add after fresh Fructus Momordicae, Rhizoma Zingiberis Recens incomparable.
The present invention is clinically for dispelling wind and ventilating the lung, and relieving cough and resolving phlegm, is applicable to improve the symptoms such as cough, expectoration.
The specific embodiment
With embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.
Embodiment 1:
Herba Ephedrae 80g, Gypsum Fibrosum 160g, Semen Armeniacae Amarum 140g, Radix Stemonae 40g, Flos Farfarae 40g, Bulbus Fritillariae Thunbergii 40g, Cortex Mori 80g, Herba Houttuyniae 80g, Caulis Mahoniae 80g, Pericarpium Citri Reticulatae 24g, Radix Glycyrrhizae 40g, fresh Fructus Momordicae 90g, Rhizoma Zingiberis Recens 10g.
Get Bulbus Fritillariae Thunbergii 20g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, adds for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct collecting decoction 1.5 hours, filter, when filtrate is concentrated into relative density and is 1.35(70 ℃, survey) clear paste, add Bulbus Fritillariae Thunbergii fine powder, add the about 860g of cane sugar powder, granulation, every packed 10g.
Embodiment 2:
Herba Ephedrae 80g, Gypsum Fibrosum 160g, Semen Armeniacae Amarum 140g, Radix Stemonae 40g, Flos Farfarae 40g, Bulbus Fritillariae Thunbergii 40g, Cortex Mori 80g, Herba Houttuyniae 80g, Caulis Mahoniae 80g, Pericarpium Citri Reticulatae 24g, Radix Glycyrrhizae 40g, fresh Fructus Momordicae 120g, Rhizoma Zingiberis Recens 15g.
Get Bulbus Fritillariae Thunbergii 20g and be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder, and all the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water twice, add for the first time 8 times of water gagings, decoct 1.5 hours, add for the second time 6 times of water gagings, decoct 1 hour, collecting decoction, filters, filtrate is concentrated into relative density be 1.38 thick paste of (85 ℃ time survey), add Bulbus Fritillariae Thunbergii fine powder and starch 40g to mix, dry, pulverize into fine powder, incapsulate every dress 0.4g.
Embodiment 3:
Herba Ephedrae 60g, Gypsum Fibrosum 180g, Semen Armeniacae Amarum 120g, Radix Stemonae 50g, Flos Farfarae 30g, Bulbus Fritillariae Thunbergii 50g, Cortex Mori 60g, Herba Houttuyniae 100g, Caulis Mahoniae 60g, Pericarpium Citri Reticulatae 18g, Radix Glycyrrhizae 50g, fresh Fructus Momordicae 60g, Rhizoma Zingiberis Recens 5g.
Get Bulbus Fritillariae Thunbergii 25g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, adds for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 6 times of water gagings, decoct collecting decoction 1.5 hours, filter, when filtrate is concentrated into relative density and is 1.30(70 ℃, survey) clear paste, add Bulbus Fritillariae Thunbergii fine powder, add the about 870g of cane sugar powder, granulation, every packed 10g.
Embodiment 4:
Herba Ephedrae 80g, Gypsum Fibrosum 140g, Semen Armeniacae Amarum 130g, Radix Stemonae 30g, Flos Farfarae 40g, Bulbus Fritillariae Thunbergii 30g, Cortex Mori 80g, Herba Houttuyniae 60g, Caulis Mahoniae 80g, Pericarpium Citri Reticulatae 18g, Radix Glycyrrhizae 30g, fresh Fructus Momordicae 85g, Rhizoma Zingiberis Recens 8g.
Get Bulbus Fritillariae Thunbergii 45g and be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder, and all the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water twice, add for the first time 8 times of water gagings, decoct 2 hours, add for the second time 6 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.42 thick paste of (85 ℃ time survey), add Bulbus Fritillariae Thunbergii fine powder and starch 140g to mix, dry, pulverize into fine powder, incapsulate every dress 0.4g.
Embodiment 5:
Herba Ephedrae 70g, Gypsum Fibrosum 170g, Semen Armeniacae Amarum 130g, Radix Stemonae 45g, Flos Farfarae 35g, Bulbus Fritillariae Thunbergii 45g, Cortex Mori 85g, Herba Houttuyniae 75g, Caulis Mahoniae 85g, Pericarpium Citri Reticulatae 21g, Radix Glycyrrhizae 45g, fresh Fructus Momordicae 72g, Rhizoma Zingiberis Recens 12g part.
Get Bulbus Fritillariae Thunbergii 20g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, add for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into relative density and is 1.35(70 ℃, surveys) clear paste, add Bulbus Fritillariae Thunbergii fine powder, technique is prepared into oral liquid routinely.
Embodiment 6:
Herba Ephedrae 90g, Gypsum Fibrosum 150g, Semen Armeniacae Amarum 130g, Radix Stemonae 45g, Flos Farfarae 35g, Bulbus Fritillariae Thunbergii 45g, Cortex Mori 75g, Herba Houttuyniae 85g, Caulis Mahoniae 75g, Pericarpium Citri Reticulatae 27g, Radix Glycyrrhizae 35g, fresh Fructus Momordicae 108g, Rhizoma Zingiberis Recens 8g.
Get Bulbus Fritillariae Thunbergii 22.5g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, add for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into relative density and is 1.30(70 ℃, surveys) clear paste, add Bulbus Fritillariae Thunbergii fine powder, technique is prepared into tablet routinely.
Comparative example 1:
Herba Ephedrae 80g, Gypsum Fibrosum 160g, Semen Armeniacae Amarum 140g, Radix Stemonae 40g, Flos Farfarae 40g, Bulbus Fritillariae Thunbergii 40g, Cortex Mori 80g, Herba Houttuyniae 80g, Caulis Mahoniae 80g, Pericarpium Citri Reticulatae 24g, Radix Glycyrrhizae 40g.
Get Bulbus Fritillariae Thunbergii 20g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, adds for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, when filtrate is concentrated into relative density and is 1.35(70 ℃, survey) clear paste, add Bulbus Fritillariae Thunbergii fine powder and starch 40g to mix, dry, be ground into fine powder, incapsulate, every dress 0.4g.
Comparative example 2:
Herba Ephedrae 80g, Gypsum Fibrosum 160g, Semen Armeniacae Amarum 140g, Radix Stemonae 40g, Flos Farfarae 40g, Bulbus Fritillariae Thunbergii 40g, Cortex Mori 80g, Herba Houttuyniae 80g, Caulis Mahoniae 80g, Pericarpium Citri Reticulatae 24g, Radix Glycyrrhizae 40g, fresh Fructus Momordicae 90g.
Get Bulbus Fritillariae Thunbergii 20g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, adds for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, when filtrate is concentrated into relative density and is 1.35(70 ℃, survey) clear paste, add Bulbus Fritillariae Thunbergii fine powder and starch 40g to mix, dry, be ground into fine powder, incapsulate, every dress 0.4g.
Comparative example 3:
Herba Ephedrae 80g, Gypsum Fibrosum 160g, Semen Armeniacae Amarum 140g, Radix Stemonae 40g, Flos Farfarae 40g, Bulbus Fritillariae Thunbergii 40g, Cortex Mori 80g, Herba Houttuyniae 80g, Caulis Mahoniae 80g, Pericarpium Citri Reticulatae 24g, Radix Glycyrrhizae 40g, Rhizoma Zingiberis Recens 10g.
Get Bulbus Fritillariae Thunbergii 20g, be ground into fine powder, standby; Gypsum Fibrosum powder is broken into coarse powder; All the other Bulbus Fritillariae Thunbergiis and Gypsum Fibrosum coarse powder, Herba Ephedrae, Semen Armeniacae Amarum etc., decoct with water secondary, adds for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, when filtrate is concentrated into relative density and is 1.35(70 ℃, survey) clear paste, add Bulbus Fritillariae Thunbergii fine powder and starch 40g to mix, dry, be ground into fine powder, incapsulate, every dress 0.4g.
Comparative example 4:
Fresh Fructus Momordicae 1kg, decocts with water secondary, adds for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, when filtrate is concentrated into relative density and is 1.35(70 ℃, survey) extractum, add starch 20g to mix, dry, be ground into fine powder, incapsulate, every dress 0.4g.
Comparative example 5:
Rhizoma Zingiberis Recens 1kg, decocts with water secondary, adds for the first time 7 times of water gagings, decoct 2 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, when filtrate is concentrated into relative density and is 1.35(70 ℃, survey) extractum, add starch 20g to mix, dry, be ground into fine powder, incapsulate, every dress 0.4g.
In order to verify its effect, the product that embodiment is obtained, in Yi Fu institute of Colleges Of Traditional Chinese Medicine Of Guangxi, the People's Hospital, the Er Fuyuanhe of Colleges Of Traditional Chinese Medicine Of Guangxi Guangxi District, has carried out clinical verification to 250 routine patients, and result is as follows:
Clinical data
Treatment group and matched group be totally 420 examples, and 150 examples are observed by Yi Fu institute of Colleges Of Traditional Chinese Medicine Of Guangxi, 150 examples are observed by Er Fu institute of Colleges Of Traditional Chinese Medicine Of Guangxi, and 120 examples are observed by the People's Hospital, Guangxi District.
One, physical data:
The object of observation of being included in is 18-65 year, and Chinese medical discrimination belongs to the cough patient of syndrome of wind-heat invading lung.Treatment group 250 examples wherein, the product that uses embodiment to obtain.Matched group 170 examples, are used reference examples to obtain product.
Two, case selection:
(1) inclusive criteria: the cough patient that all Chinese medical discriminations belong to syndrome of wind-heat invading lung all can include in to observe and resemble.
(2) exclusion standard (comprising inadaptation and rejecting standard)
1, the age is under-18s or over-65s, gestation or women breast-feeding their children, those who are allergic to this drug;
2, be associated with the serious primary disease such as cardiovascular, liver, kidney and hemopoietic system, psychotic;
3, do not meet inclusive criteria, not medication in accordance with regulations, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
Three, diagnostic criteria:
(1) tcm diagnosis standard (cough syndrome of wind-heat invading lung): rough, sticky white or yellow, the pharyngalgia of coughing up phlegm of coughing or to cough hoarseness mute or have a heating, slight chill, mouthful micro-thirsty, red tip of the tongue, white or yellow thin fur, floating pulse stricture of vagina.
(2) Western medicine diagnose standard: the Diseases of WM that assertive evidence relates to, by the up-to-date diagnostic criteria of this disease, carry out with reference to < < clinical disease diagnosis according to curing improvement standard > >.
Four, method of administration and the course for the treatment of:
The oral embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5 and comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5.
Each 2 of capsule, 0.5g/ grain (content 0.4g); Each 15 milliliters of oral liquid; Each one bag of granule, 10g/ bag.
Every day 3 times, be used in conjunction 7 days.
Five, observational technique:
Curative effect judgement is directly made by observer.Viewing duration is without other similar medicines.
Six, therapeutic evaluation:
Efficacy assessment standard:
1, recovery from illness: symptom, sign disappear or substantially disappear;
2, effective: symptom, sign are clearly better;
3, effective: symptom, sign take a turn for the better;
4, invalid: not reach above standard person.
Table one, the clinical observation of the present invention to cough-relieving
Compositions Number of cases Recovery from illness Effective Effectively Invalid Total effective rate %
Embodiment 1 50 12 21 13 4 92
Embodiment 2 50 11 23 13 3 94
Embodiment 3 50 14 21 11 4 92
Embodiment 4 50 15 19 13 3 94
Embodiment 5 50 10 13 17 5 90
Comparative example 1 50 8 18 13 9 82
Comparative example 2 50 8 15 20 7 86
Comparative example 3 50 9 17 16 8 84
Comparative example 4 10 1 1 1 7 30
Comparative example 5 10 0 1 1 8 20
Side effect:
Treatment group 250 examples, matched group 170 examples, all do not find obvious adverse reaction and toxic and side effects at viewing duration.
Conclusion
Embodiment 1-5, the product that comparative example 1-3 obtains has the effect of reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing, can be used for the cough with copious phlegm of syndrome of wind-heat invading lung, fever of the body, the diseases such as xerostomia wish drink; The cough suppressing effect of comparative example 4-5 is undesirable; The product that embodiment 1-5 obtains compares the product that ratio 1-3 obtains and has better cough suppressing effect.

Claims (3)

1. a medicine with clearing away lung-heat to relieve cough effect, is characterized in that it is made by the raw material of following weight parts:
Herba Ephedrae 60-100 part, Gypsum Fibrosum 140-180 part, Semen Armeniacae Amarum 120-160 part, Radix Stemonae 30-50 part, Flos Farfarae 30-50 part, Bulbus Fritillariae Thunbergii 30-50 part, Cortex Mori 60-100 part, Herba Houttuyniae 60-100 part, Caulis Mahoniae 60-100 part, Pericarpium Citri Reticulatae 18-30 part, Radix Glycyrrhizae 30-50 part, fresh Fructus Momordicae 60-120 part, Rhizoma Zingiberis Recens 5-15 part.
2. a kind of pharmaceutical composition with clearing away lung-heat to relieve cough effect according to claim 1, is characterized in that: the weight portion of each raw material is:
Herba Ephedrae 70-90 part, Gypsum Fibrosum 150-170 part, Semen Armeniacae Amarum 130-150 part, Radix Stemonae 35-45 part, Flos Farfarae 35-45 part, Bulbus Fritillariae Thunbergii 35-45 part, Cortex Mori 75-85 part, Herba Houttuyniae 75-85 part, Caulis Mahoniae 75-85 part, Pericarpium Citri Reticulatae 21-27 part, Radix Glycyrrhizae 35-45 part, fresh Fructus Momordicae 72-108 part, Rhizoma Zingiberis Recens 8-12 part.
3. a kind of pharmaceutical composition with clearing away lung-heat to relieve cough effect according to claim 2, is characterized in that: the weight portion of each raw material is:
80 parts, Herba Ephedrae, 160 parts, Gypsum Fibrosum, 140 parts of Semen Armeniacae Amarums, 40 parts of the Radixs Stemonae, 40 parts of Flos Farfaraees, 40 parts of Bulbus Fritillariae Thunbergiis, 80 parts of Cortex Mori, 80 parts of Herba Houttuyniae, 80 parts of Caulis Mahoniaes, 24 parts of Pericarpium Citri Reticulataes, 40 parts, Radix Glycyrrhizae, 90 parts of fresh Fructus Momordicaes, 10 parts, Rhizoma Zingiberis Recens.
CN201310738384.2A 2013-12-27 2013-12-27 Pharmaceutical composition with function of removing heat from lung to relieve cough Pending CN103705890A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468950A (en) * 2017-06-30 2017-12-15 成都恒凌科技有限公司 A kind of cough-relieving paste
CN107468951A (en) * 2017-06-30 2017-12-15 成都恒凌科技有限公司 A kind of anti-cough granules
CN112316076A (en) * 2020-12-11 2021-02-05 海南黄嘉堡生物科技有限公司 Lung healing clearing formula and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840122A (en) * 2006-01-23 2006-10-04 广西金页制药有限公司 Chinese medicinal preparation for stopping cough and resolving phlegm and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840122A (en) * 2006-01-23 2006-10-04 广西金页制药有限公司 Chinese medicinal preparation for stopping cough and resolving phlegm and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468950A (en) * 2017-06-30 2017-12-15 成都恒凌科技有限公司 A kind of cough-relieving paste
CN107468951A (en) * 2017-06-30 2017-12-15 成都恒凌科技有限公司 A kind of anti-cough granules
CN112316076A (en) * 2020-12-11 2021-02-05 海南黄嘉堡生物科技有限公司 Lung healing clearing formula and preparation method thereof

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Application publication date: 20140409