CN100475258C

CN100475258C - Antasthmatic

Info

Publication number: CN100475258C
Application number: CNB2006100933964A
Authority: CN
Inventors: 史桂芳; 曹丽萍
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-06-20
Filing date: 2006-06-20
Publication date: 2009-04-08
Anticipated expiration: 2026-06-20
Also published as: CN1895604A

Abstract

A Chinese medicine 'Cough stopping' for treating cough is prepared from 6 Chinese-medicinal materials including liquorice, stemona root, tendrilled fritillary bulb, scutellaria root, etc.

Description

Antasthmatic

Affiliated technical field

The present invention relates to a kind of Chinese medicine, relating to a kind of specifically is the antasthmatic of raw material treatment cough with the Chinese herbal medicine.

Background technology

Cough is the respiratory system commonly encountered diseases.Differential diagnosis in tcm: cough is pulmonary's illness, insufficiency of lung-QI, failure of defensive QI to protect the body against pathogen is loose in the lung, perspire easily, the flu that is easy to get, lung governing qi is shared a common fate, main a surname sends out and respectful falling, and can not declare to send out and stop up and stagnate, and breast is inaccessible yearningly, and coughing spits prolongs, superinverse also can be led existing cough, pant if lung qi can not respectful falling, affection of exogenous wind-cold and the cough that causes, cough and be one of cardinal symptom, thin sputum white is coughed violent, reflexive has been shaken headache, and the cold and heat floating pulse promptly is that wind and cold is violated due to the lung.The doctor trained in Western medicine theory, cough is that respiratory mucosa is subjected to physics, behind the bacteroidal inflammatory stimulus of chemistry, a kind of defensive reflex cough who is produced is again one of common sympton of respiratory system disease, during bronchitis, the tube wall inflammatory changes, congested, edema, thicken leukocyte, erythrocyte, lymphocyte and cytophagy cellular infiltration, tube chamber narrows down, the sticking glandular secretion that converges of trachea increases, add inflammatory stimulus again, can produce tracheal smooth muscle spasm in various degree, and cause dysfunction of ventilation, formation is breathed heavily and is suppressed, beginning is zest dry cough, and then expectoration, white foam sample expectorant, inflammation is further made progress, yellow purulent sputum is suppressed then to breathe heavily and is increased the weight of, and can produce four big complication of upper respiratory tract infection if untimely medication is controlled, that is, one, up sinusitis; Two, to the both sides otitis media; Three, back pharynx back abscess of nose; Four, reach bronchitis and pneumonia downwards.The many policies with the combination of Chinese and Western medicine of present Therapeutic Method, inflammation-diminishing and cough-controlling, is relievingd asthma at spasmolytic, removes bronchial muscular spasm.

Summary of the invention

The object of the present invention is to provide a kind of cough suppressing effect good, treating both the principal and secondary aspects of a disease, short treating period, the cure rate height, treatment time is short, to the undamaged antasthmatic of health.

Medicine of the present invention be the inventor based on motherland's medical science to pathogenetic understanding of coughing, and based on secret prescription handed down in the family from generation to generation and traditional Chinese medicine, the clinical trial of combining with the practice for many years of oneself through for many years, checking draws repeatedly.

Medicine of the present invention is made by following component:

Radix Glycyrrhizae 1--15 weight portion, Herba Ephedrae 1--15 weight portion, Radix Platycodonis 2--15 weight portion, Radix Stemonae 5--20 weight portion, Bulbus Fritillariae Cirrhosae 2--15 weight portion, Radix Scutellariae 3-15 weight portion.With these drug regimens, make each efficacy of drugs produce synergism, thereby can effectively treat cough.The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have curative effect preferably in the following weight parts scope.

Preferred weight part is:

Radix Glycyrrhizae 1.5--9 weight portion, Herba Ephedrae 2--9 weight portion, Radix Platycodonis 3--10 weight portion, Radix Stemonae 5--15 weight portion, Bulbus Fritillariae Cirrhosae 3--10 weight portion, Radix Scutellariae 5-10 weight portion.

Optimum weight part is:

Radix Glycyrrhizae 5 weight portions, Herba Ephedrae 5 weight portions, Radix Platycodonis 6 weight portions, the Radix Stemonae 8 weight portions, Bulbus Fritillariae Cirrhosae 6 weight portions, Radix Scutellariae 7 weight portions.

In order to reach better curative effect, also add the crude drug of following component in the crude drug of drug component of the present invention: Pheretima 2--12 weight portion, Ganoderma 5--15 weight portion.

Be preferably: Radix Glycyrrhizae 1.5--9 weight portion, Herba Ephedrae 2--9 weight portion, Radix Platycodonis 3--10 weight portion, Radix Stemonae 5--15 weight portion, Pheretima 4.5--9 weight portion, Bulbus Fritillariae Cirrhosae 3--10 weight portion, Ganoderma 6--12 weight portion, Radix Scutellariae 5-10 weight portion.

The best is: Radix Glycyrrhizae 5 weight portions, Herba Ephedrae 5 weight portions, Radix Platycodonis 6 weight portions, the Radix Stemonae 8 weight portions, Pheretima 5 weight portions, Bulbus Fritillariae Cirrhosae 6 weight portions, Ganoderma 8 weight portions, Radix Scutellariae 7 weight portions.

The preparation method of medicine of the present invention: Herba Ephedrae, Radix Glycyrrhizae, the Radix Stemonae are made extract powder respectively, grind into powder stand-by after Pheretima is steamed and did in 30 minutes, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Ganoderma clean up the back, and levigation is stand-by respectively, take by weighing Herba Ephedrae powder extract powder, Radix Glycyrrhizae extractum powder by drug weight part, Radix Stemonae extract powder, Pheretima powder, Bulbus Fritillariae Cirrhosae powder, balloonflower powder, Ganoderma powder, each medicated powder can be taken after mixing, and medicine is looked the administration of cough weight, need not be by the medication course of treatment.

Beneficial effect of the present invention is: drug regimen of the present invention makes each medicine produce synergism, can effectively treat cough.The feature of this medicine is based on secret prescription handed down in the family from generation to generation, be that grandfather's grandfather promptly practises medicine before 200 years in the period of the Emperor XianFeng, former generation people are in the process of practising medicine, summed up abundant clinical practice, allot relieving cough and asthma good medicine targetedly, in ancestors practise medicine process, firmly got hundred li broad masses' of circumference favorable comment.With the clinical experience in more than 40 years, on this basis, make cough-relieving benefit produce effects more in person.The antitussive of being joined is that the antitussive of selling on the market is unrivaled.

Medicine of the present invention comprises Radix Glycyrrhizae, Herba Ephedrae, Radix Platycodonis, the Radix Stemonae, Pheretima, Bulbus Fritillariae Cirrhosae, Ganoderma, Radix Scutellariae, and the pharmacological effect of each medicine of distinguishing the flavor of is as follows:

Radix Glycyrrhizae, flat GUIXIN lung taste warp, eliminates the phlegm at nourishing the lung to arrest cough, slightly the tool antiasthmatic effect can be used for the multiple cough of cold and heat and asthenia and sthenia with the disease compatibility, new chronic cough is coughed, and has expectorant not have all benefits of expectorant, according to modern " Chinese materia medica " etiology and pathology: " wet three gas of wind and cold are assorted extremely; close and be numbness ", wet three heresies of wind and cold are arthromyodynia main causes, but children's is in the majority with heat symptom-complex, arthromyodynia is no exception, because children's is a pure-yang constituent, wind and cold is easy to heat-transformation, so show as " rheumatism pyretic arthralgia " clinically, it is scorchingly hot mainly to show as rheumatism more.

Herba Ephedrae: the little hardship of acrid in the mouth is gone into lung meridian, lung qi dispersing air to open space between skin and muscles, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, dispersing wind-cold, cough-relieving is dried breathes heavily, and can untie the closing of fur so that lung qi a surname is smooth, the gas of cataract superinverse, with multiple lung department respectful fall normal, so dried the breathing heavily of improvement." Chinese materia medica " (existing institution of higher learning state-compiled textbook) work, its chemical constituent, be mainly ephedrine, and contain a spot of pseudo-ephedrine, volatilization wet goods chemical compound, its pharmacological action, ephedrine can make the sweat gland secretion that is in the human body in the hot environment increase and discharge, so the merit of bringing down a fever and inducing sweat is arranged, resolve phlegm effect is arranged, alleviate the effect of bronchial muscular spasm, so relieving asthma, can strengthen the effect of mental and physical efforts contractility and diuresis, so alleviated the pulmonary hypertension that pneumonia causes, the effect of anti-pneumonia heart failure is arranged, volatile oil has inhibitory action to influenza virus, and its methanolic extract has antiinflammatory action, and decoct has the effect of resisting pathogenic microbes.

Radix Platycodonis, bitter in the mouth is hot flat, returns lung meridian, opens lung qi dispersing gas, dispelling phlegm and relieving sore-throat, no matter cold and heat all can." Chinese materia medica " modern study, its chemical constituent contains multiple saponin, be mainly platycodigenin, Polygalacic acid and a small amount of platycogenic acid etc., all relieving sore throat to recover voice,, gastric mucosa pharyngeal to the oral cavity directly stimulates, the increase of reflection, the hypersecretion of bronchus body of gland is diluted thereby expectorant is converged, be easy to discharge, antitussive effect is arranged.Simultaneously also have antiinflammatory and immunization, strengthen cytophagous phagocytic function, strengthen leukocytic sterilizing ability, improve lysosomal activity, relaxing smooth muscle is alleviated the spasm of bronchial smooth muscle, reaches the purpose of relieving cough and asthma.

The Radix Stemonae, the sweet in the mouth toil is gone into lung meridian, the moistening the lung and resolving phlegm cough-relieving, sweet profit hardship is fallen, tepor is not dry, new chronic cough is coughed, pertussis, pulmonary tuberculosis cough, no matter wound, internal injury, cough caused by dryness, chronic cough all available it." Chinese materia medica " modern study, its chemical constituent mainly contains Ethyl 2-methylbutyl ketoxine, radix stemonae tuberosae alkali and contains glycolipid proteinoid etc., pharmacological action, can reduce the irritability of respiratory center, suppress coughre flex, and play the effect of cough-relieving, bronchial muscular spasm there is relexation, its intensity is similar to peace tea alkali, in vitro tests all has inhibitory action to bacillus such as tubercule bacillus, streptococcus pneumoniae, coccus, streptococcus, diphtheria, dysentery, green pus, typhoid fever, and popularity flu and dermatophytes etc. all have inhibitory action.

Pheretima, salty in the mouth is cold, returns liver spleen urinary bladder channel, the heat clearing away arresting convulsion, collateral dredging is relievingd asthma, diuresis, this moral character is walked to scurry, and is good at the meridian dredging, removing obstruction in the collateral to relieve pain, cold in nature falling let out, clearing lung, relieving asthma is controlled hot and suffocating heap soil or fertilizer over and around the roots lung, and respectful the gasping for breath of falling of pneumonia has wheezing commonly used in shouting, and the compound recipe medication all can prove effective." Chinese materia medica " modern study, its chemical constituent contains several amino acids, glutamic acid, aspartic acid, leucine, content is the highest, also contains various trace element such as ferrum, zinc, magnesium, copper, and its pharmacological action has good refrigeration function, also have effects such as enhance immunity, antitumor, antibiotic diuresis.

Bulbus Fritillariae Cirrhosae, flavor: sweetness and bitterness, be slightly cold, return lung heart channel, removing heat-phlegm, nourishing the lung to arrest cough, mass dissipating and swelling eliminating, the chronic consumptive disease cough, lung-heat type cough, the internal injury chronic cough, the disease of expectorant heat is all effective." ancient books summary " " book on Chinese herbal medicine converge with speech " Bulbus Fritillariae Uninbracteatae has the dissipating depression of QI therapeutic method to keep the adverse QI flowing downwards, the effect of reducing phlegm also, lung moistening expectorant, cough-relieving pyridine are breathed heavily, the levying of chronic consumptive disease fire knot, Bulbus Fritillariae Uninbracteatae is specially taken charge of beneficial agent." Chinese materia medica " modern study, chemical constituent are multiple microorganism alkali, and the Bulbus Fritillariae Uninbracteatae total alkaloids all has the effect of relieving cough and expelling phlegm, and antitumor is still arranged, the effect that diuresis is antibiotic.

Ganoderma, sweet in the mouth is flat, returns lung Liver and kidney warp, relieving cough and asthma, invigorating QI and tranquilization, energy reinforcing the heart blood, the benefit motive, tranquilizing mind, benefiting qi and nourishing blood are controlled chronic consumptive disease disease, and the flat temperature partially of property is gone into lung meridian, replenishing and restoring lung-QI, warming the lung for resolving phlegm can be controlled phlegm retention syndrome, the cold physique cough, abundant expectoration asthma person is excellent to expectorant warm type or asthenic cold type curative effect especially.

Radix Scutellariae, withered purte the white, the clear large intestine of son damp and hotly all can.Bitter in the mouth is cold, returns lung, gallbladder, spleen, stomach warp.Heat clearing away lung-fire and part of the body cavity above the diaphragm housing the heart and lungs excess-heat are used for lung-heat and stop up cough due to holding back, the tired temperature of hyperpyrexia due to the thick abundant expectoration of expectorant, middle part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, flushed face and red lips etc." Chinese materia medica " modern study, its main component are noroxylin, baicalin wogonin, wogonoside etc.Its decoct has a broad-spectrum antibacterial action external, Bacillus typhi, bacillus pyocyaneus, dysentery bacterium, bordetella pertussis and staphylococcus, streptococcus, Diplococcus pneumoniae, meningococcus etc. all there is inhibitory action, also have effects such as analgesic blood pressure lowering, diuresis function of gallbladder promoting in addition, synergism is arranged with ephedrine.

Because of Pheretima go into more lung meridian, taste through, cough illness because of, main lung sense pathogen, expectorant is stopped up due to the air flue, the heap soil or fertilizer over and around the roots of wind and cold diseases caused by exogenous pathogenic factor space between skin and muscles is held back obstructed, and lung qi is gloomy, and a surname falls unbalance, its gas is non-return, tachypnea, gurgling with sputum, satisfy into cough with asthma,, transfer lung qi more so this product is gone into lung meridian, trachea, and reach relieving cough and asthma, because of its property of Pheretima is walked to scurry, play dredging the meridian, relieving asthma and reach.Above medicine has returns the taste warp, the effect of spleen invigorating stomach strengthening is all arranged, and the doctor trained in Western medicine theory is said, after pathogen entered human body, each system was subjected to influence in various degree, the spleen invigorating stomach strengthening, diet is adjusted, and can increase the intrinsic resistance of body, thereby play a leading role.This medicine feature is based on the traditional Chinese medical science, symptomatic treatment, and treating both the principal and secondary aspects of a disease, when using the antibiotic medicine, this medicine of dual-purpose reaches good Expected Results.Medicine of the present invention can also be regulated the whole machine body state except that to the lung meridian.From being regulated mentally with on the body deficient syndrome, make whole machine body from diet, sleep, can both be adjusted to optimum state mentally, thereby improve the intrinsic resistance of body, the endogenous cause of ill of body is played a leading role, strengthen resistance against diseases, quicken the recovery from illness of disease.

Clinical observation of the present invention:

Physical data: cough is one of cardinal symptom of the disease that causes of affection of exogenous wind-cold, that is to say the upper respiratory tract infection (throat is with upper part nose, mouth, pharyngeal) that causes after having a cold in various degree and under breathe infection (below the throat, trachea, bronchus, bronchia, lung) one of cardinal symptom, incident dispensable fever, dizziness, breathe heavily and suppress etc., promptly the people known flu.Clearly say the cough that pharyngitis (red and swollen around the scorching portion) causes, reach the cough that tracheitis causes.Morbidity is all arranged throughout the year, because of the wind and cold invasion and attack cause, so morbidity is many in cold season, based on late autumn, winter, the early spring, gender's zero difference is bigger with old people and child's proportion.

Accept patient's totally 9500 examples for medical treatment, the age has until old every year from infant.

Diagnostic criteria: because of cough is the cardinal symptom of respiratory tract infection, can diagnose so the patient has the cough symptom, but Differential Diagnosis being the cough that is caused by pharyngitis, is the cough that lower respiratory infection causes by tracheitis still.

Therapeutic Method:

General every day, potion divided secondary oral, and 3-10 days medicines of the present invention are taken in the serious symptom cough when taking the antibiotic medicine; The moderate cough was with medicine 3-5 of the present invention days; Slight cough was with medicine 1-2 of the present invention days.

Efficacy assessment standard:

Cure: the cough complete obiteration.

Effectively: cough disappears substantially.

Invalid: the commentaries on classics of not getting better of coughing.

Therapeutic outcome:

(1) the treatment of cough result such as the following table that cause of trachea lower respiratory tract

(2) the treatment of cough result such as the following table that cause of pharyngitis

The specific embodiment

A kind of antitussive, make by following component:

Radix Glycyrrhizae 5 weight portions, Herba Ephedrae 5 weight portions, Radix Platycodonis 6 weight portions, the Radix Stemonae 8 weight portions, Pheretima 5 weight portions, Bulbus Fritillariae Cirrhosae 6 weight portions, Ganoderma 8 weight portions, Radix Scutellariae 7 weight portions.

The preparation method of medicine of the present invention: Herba Ephedrae, Radix Glycyrrhizae, the Radix Stemonae are made extract powder respectively, grind into powder stand-by after Pheretima is steamed and did in 30 minutes, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Ganoderma clean up the back, and levigation is stand-by respectively, take by weighing Herba Ephedrae powder extract powder, Radix Glycyrrhizae extractum powder by drug weight part, Radix Stemonae extract powder, Pheretima powder, Bulbus Fritillariae Cirrhosae powder, balloonflower powder, Ganoderma powder, each medicated powder is taken after mixing, and medicine is looked the administration of cough weight, need not be by the medication course of treatment.

Claims

1, a kind of antitussive is characterized in that: this medicine is made by following bulk drugs: Radix Glycyrrhizae 1-15 weight portion, Herba Ephedrae 1-15 weight portion, Radix Platycodonis 2-15 weight portion, Radix Stemonae 5-20 weight portion, Bulbus Fritillariae Cirrhosae 2-15 weight portion, Radix Scutellariae 3-15 weight portion.

2, antitussive according to claim 1 is characterized in that: wherein the consumption of each crude drug is: Radix Glycyrrhizae 1.5-9 weight portion, Herba Ephedrae 2-9 weight portion, Radix Platycodonis 3-10 weight portion, Radix Stemonae 5-15 weight portion, Bulbus Fritillariae Cirrhosae 3-10 weight portion, Radix Scutellariae 5-10 weight portion.