CN103479932B

CN103479932B - One treats bronchitic Chinese medicine composition and preparation method thereof

Info

Publication number: CN103479932B
Application number: CN201310470398.0A
Authority: CN
Inventors: 郭红霞; 齐季红
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-25
Filing date: 2013-09-25
Publication date: 2015-09-23
Anticipated expiration: 2033-09-25
Also published as: CN103479932A

Abstract

The invention discloses one and treat bronchitic Chinese medicine composition, this pharmaceutical pack is containing Fel Serpentis, the Rhizoma Pinelliae, Herba Ephedrae, Fructus Forsythiae, Folium Isatidis, Radix Isatidis, Semen Armeniacae Amarum, Herba Menthae, the Chinese medicine ingredients such as Bulbus Fritillariae Cirrhosae, respective drug effect can not only be ensured after making decoct, can also complement each other, learn from other's strong points to offset one's weaknesses, whole Chinese medicine composition is made to have good cough-relieving, reduce phlegm, antiinflammatory, effect of sterilization, effectively can eliminate the cough that bronchitis brings, abundant expectoration, many symptoms such as pain and breathing discomfort, bronchitis can be cured from root, also the effectively bronchitic recurrence of containment simultaneously, promote patient's recovery from illness.In addition, the invention also discloses a kind of preparation method for the treatment of bronchitic Chinese medicine composition, the method is simple, convenient, easy and cost is low.

Description

One treats bronchitic Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, relate to one specifically and treat bronchitic Chinese medicine composition and preparation method thereof.

Background technology

Bronchitis refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Clinically with cough, expectoration or with pant and the chronic process of recurrent exerbation for feature.If the state of an illness is slowly in progress, Chang Bingfa obstructive emphysema, even pulmonary hypertension, pulmonary heart disease.It is a kind of commonly encountered diseases of serious harm human health, common with old people again.Bronchitis main cause is that the repeated infection of virus and antibacterial defines bronchial chronic nonspecific inflammation.When there's a sudden fall in temperature, under respiratory tract small blood vessel spasm ischemia, defense function, degradation is beneficial to pathogenic, the chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill, smoking makes the variation of bronchospasm, mucosa, ciliary movement reduces, mucous secretion increases advantageous infectivity, and intolerance factors also has certain relation.

The bronchitic medicine of current treatment is a lot, general based on inflammation-diminishing and cough-controlling, multiplex antibiotics Western medicine, and Western medicine easily develops immunity to drugs, after healing, disease is once recurrence, take this type of antibiotic medicine again, curative effect is poor, does not even work, bring painful and unnecessary trouble to patient, and take antibiotics Western medicine for a long time and bring more side effect to patient.

Summary of the invention

The problem to be solved in the present invention is to provide a kind of good effect, instant effect and the bronchitic Chinese medicine composition for the treatment of not easily developed immunity to drugs, and preparation method thereof, this preparation method is simple, convenient, easy and cost is low.

For solving the problem, the technical solution adopted in the present invention is:

One treats bronchitic Chinese medicine composition, it is characterized in that: this medicine comprises following component:

Fel Serpentis 3-8 gram, the Rhizoma Pinelliae 8-12 grams, Herba Ephedrae 3-8 gram, Fructus Forsythiae 3-8 gram, Folium Isatidis 3-8 gram, Radix Isatidis 3-8 gram, Herba Patriniae 10-20 gram, Radix Platycodonis 8-12 gram, Cortex Mori 8-12 grams, 8-12 grams, Radix Glycyrrhizae, Radix Scrophulariae 8-12 gram, Rhizoma Dioscoreae 8-12 grams, Radix Ophiopogonis 3-8 gram, Rhizoma Coptidis 3-8 grams, Semen Coicis 10-20 gram, Semen Armeniacae Amarum 8-12 gram, Herba Menthae 3-8 gram, Bulbus Fritillariae Cirrhosae 8-12 gram.

As a kind of preferred version:

This medicine comprises following component:

Fel Serpentis 3 grams, the Rhizoma Pinelliae 8 grams, 3 grams, Herba Ephedrae, Fructus Forsythiae 3 grams, Folium Isatidis 3 grams, Radix Isatidis 3 grams, Herba Patriniae 10 grams, Radix Platycodonis 8 grams, Cortex Mori 8 grams, 8 grams, Radix Glycyrrhizae, Radix Scrophulariae 8, Rhizoma Dioscoreae 8 grams, Radix Ophiopogonis 3 grams, Rhizoma Coptidis 3, Semen Coicis 10 grams, 8 grams, Semen Armeniacae Amarum, Herba Menthae 3 grams, Bulbus Fritillariae Cirrhosae 8 grams.

As a kind of preferred version:

This medicine comprises following component:

Fel Serpentis 8 grams, the Rhizoma Pinelliae 12 grams, 8 grams, Herba Ephedrae, Fructus Forsythiae 8 grams, Folium Isatidis 8 grams, Radix Isatidis 8 grams, Herba Patriniae 20 grams, Radix Platycodonis 12 grams, Cortex Mori 12 grams, 12 grams, Radix Glycyrrhizae, Radix Scrophulariae 12 grams, Rhizoma Dioscoreae 12 grams, Radix Ophiopogonis 8 grams, Rhizoma Coptidis 8 grams, Semen Coicis 20 grams, 12 grams, Semen Armeniacae Amarum, Herba Menthae 8 grams, Bulbus Fritillariae Cirrhosae 12 grams.

As a kind of preferred version:

This medicine comprises following component:

Fel Serpentis 5 grams, the Rhizoma Pinelliae 5 grams, 5 grams, Herba Ephedrae, Fructus Forsythiae 5 grams, Folium Isatidis 5 grams, Radix Isatidis 5 grams, Herba Patriniae 15 grams, Radix Platycodonis 10 grams, Cortex Mori 10 grams, 10 grams, Radix Glycyrrhizae, Radix Scrophulariae 10 grams, Rhizoma Dioscoreae 10 grams, Radix Ophiopogonis 5 grams, Rhizoma Coptidis 5 grams, Semen Coicis 15 grams, 10 grams, Semen Armeniacae Amarum, Herba Menthae 5 grams, Bulbus Fritillariae Cirrhosae 10 grams.

Treat a preparation method for bronchitic Chinese medicine composition, it is characterized in that: said method comprising the steps of:

A, capture each Chinese herb by weight, prepare enough the water of five times of Chinese medicine composition gross weights;

B, first Herba Ephedrae is put into crucible and decoct, remove foam on it, and then all the other each Chinese herbs are put into crucible with boiling, first very hot oven seethes with excitement to water, continues five minutes, less fire decocts half an hour;

C, filtering medicinal residues, obtain institute's drink-service medicinal liquid.

Wherein, Fel Serpentis contains abundant trace copper, ferrum, calcium, magnesium, injection Vitamin B_6 etc., they are being safeguarded people's hormone in vivo and are delaying in the vital movements such as senility of humanbody, play an important role, often take Fel Serpentis, by adjustment human internal environment, improve human body circulation, enhancing immunity, reaches the object of outer sick treatment by oral administration of medicines.Fel Serpentis also has effect of anti-inflammatory analgetic, relieving cough and asthma, this effect that the present invention utilizes just, it and Bulbus Fritillariae Cirrhosae with the use of, effect is better.

The Rhizoma Pinelliae enters lung, spleen, stomach warp, has expectorant saliva, cough-relieving retroaction, energy strengthening the spleen and stomach, dissipating depression of QI eliminating stagnation, and has the pharmacological action obviously suppressing to cough, eliminate the phlegm.

Herba Ephedrae has effect of relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema, loose carbuncle of yin nature, eliminating mass knot, its effective ingredient is ephedrine, d-pseudo-ephedrine, volatile oil and 2,3,5,6-tetramethylpyazine L-α-terpinenol, these compositions can suppress irritated tramsmitter release effectively, and can antibacterial, antiviral, relieving cough and expelling phlegm.

Fructus Forsythiae bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Chinese medicine cures mainly calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain etc.

Folium Isatidis has effect of heat clearing away, removing toxic substances, removing heat from blood, hemostasis, can control the symptoms such as epidemic febrile disease intenseness of heat excessive thirst, influenza, acute pneumonia.

Radix Isatidis has heat-clearing and toxic substances removing, removing heat from blood profit cigarette, bactericidal antiphlogistic, antiviral effect.

Herba Patriniae has heat-clearing and toxic substances removing, the effect coughed is equalled in anti-inflammatory analgetic, damp eliminating.

Radix Platycodonis bitter in the mouth, pungent, property is put down, and enters lung meridian, has lung qi dispersing and eliminate the phlegm, removing pus and relieving carbuncle, relieving cough and relieving asthma, effect of clearing away heat from the throat and easing the chest.

Cortex Mori sweet in the mouth, cold in nature, return lung meridian, there is eliminating pathogen from the lung for relieving asthma, effect of inducing diuresis to remove edema.

Radix Glycyrrhizae nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, and middle emergency, lung moistening, and removing toxic substances, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, laryngopharynx swelling and pain, peptic ulcer.

Radix Scrophulariae has effect of clearing away heat and cooling blood, hard masses softening and resolving, enhancing body immunity.

Rhizoma Dioscoreae has spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, and is mainly used in ruins and breathes with cough.

Radix Ophiopogonis sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have promoting diuresis to eliminate damp pathogen, spleen invigorating, reduce phlegm, effect of mind tranquilizing and the heart calming.

Rhizoma Coptidis has effect of heat clearing and damp drying, eliminating fire and detoxication.

Semen Coicis spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, for symptoms such as emphysema, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.

Semen Armeniacae Amarum nature and flavor are bitter, warm, enter lung, large intestine channel, expelling phlegm for arresting cough, relieving asthma, intestine moistening, control exogenous cough, dyspnea with fullness of the chest, sore throat, the dry constipation of breast.

Herba Menthae acrid in the mouth, cool in nature.Return lung, Liver Channel.Cure mainly: dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.

Bulbus Fritillariae Cirrhosae has effect of nourishing the lung to arrest cough, resolving phlegm and relieving asthma, removing heat-phlegm.

In above-mentioned Chinese medicine, for Fel Serpentis, Herba Ephedrae, the Rhizoma Pinelliae, Radix Platycodonis, Semen Armeniacae Amarum, Cortex Mori, Radix Ophiopogonis, Bulbus Fritillariae Cirrhosae principal agent, auxiliary have Radix Scrophulariae, Rhizoma Dioscoreae, Semen Coicis promotes the production of body fluid lung benefiting, strengthen body immunity, Fructus Forsythiae, Folium Isatidis, Radix Isatidis, Rhizoma Coptidis, Herba Patriniae bactericidal, and Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, respective drug effect can not only be ensured after making decoct, can also complement each other, learn from other's strong points to offset one's weaknesses, whole Chinese medicine composition is made to have good cough-relieving, reduce phlegm, antiinflammatory, effect of sterilization, effectively can eliminate the cough that bronchitis brings, abundant expectoration, many symptoms such as pain and breathing discomfort, bronchitis can be cured from root, also the effectively bronchitic recurrence of containment simultaneously, promote patient's recovery from illness.

Detailed description of the invention

Embodiment 1: one treats bronchitic medicine, this medicine comprises following component:

Fel Serpentis 3, the Rhizoma Pinelliae 8 grams, 3 grams, Herba Ephedrae, Fructus Forsythiae 3 grams, Folium Isatidis 3 grams, Radix Isatidis 3 grams, Herba Patriniae 10 grams, Radix Platycodonis 8 grams, Cortex Mori 8 grams, 8 grams, Radix Glycyrrhizae, Radix Scrophulariae 8, Rhizoma Dioscoreae 8 grams, Radix Ophiopogonis 3 grams, Rhizoma Coptidis 3, Semen Coicis 10 grams, 8 grams, Semen Armeniacae Amarum, Herba Menthae 3 grams, Bulbus Fritillariae Cirrhosae 8 grams.

First, Chinese herb described above is prepared by grams, be soaked in water half an hour, wherein the weight of water is five times of Chinese herb composition total weight, first very hot oven decoction is seethed with excitement to water, continue five minutes, after change little fire decoct half an hour, if period water reduce very fast, can add a small amount of water supplement, drink when after elimination medicinal residues, equitemperature is moderate, every part decocts once, can drink at twice, and Ganderwa is respectively sooner or later half an hour after the meal, a course for the treatment of is three days, general once fully recovering to two courses for the treatment of.

In this embodiment, the dosage of each taste Chinese medicine is less, is applicable to children's, bronchitis symptom comparatively the lighter.

Embodiment 2: one treats bronchitic medicine, this medicine comprises following component:

In this embodiment, the dosage of each taste Chinese medicine is comparatively large, is applicable to adult, the heavier person of bronchitis symptom.

Embodiment 3: one treats bronchitic medicine, this medicine comprises following component:

Pharmacological evaluation:

In this embodiment, the dosage of each taste Chinese medicine is moderate, is applicable to multiple-age bracket crowd, has good therapeutic effect, also can suitably reduce or increase the grams of each Chinese medicine on this basis, but should follow the doctor's advice usually bronchitis.

For checking the property of medicine of medicine of the present invention further, choosing white mice, making white mice be test body by anthropic factor, carry out cough-relieving respectively, experiment of reducing phlegm, each laboratory mouse is 50, male and female half and half, random point five groups, often organizes ten.The experimental result data form obtained is as follows:

(1) cough-relieving

By strong aqua ammonia nebulization, evaluate the antitussive action of this medicine.White mice divides 5 groups, i.e. normal saline group, positive drug control group (ZHENKELING 6.2ml/kg), each one group of this Medications Example 1, embodiment 2, embodiment 3, continuous gastric infusion 3d, after 3d administration 40min, put by white mice in 1000ml closed glass container, spray into ammonia 1:7 with ultrasound atomizer, 3s excites white mice to cough, there is contraction of abdominal muscle with white mice simultaneously, contracting breast, open one's mouth (cough sound with or without) is cough standard, record, draws and coughs white mice cough number of times in incubation period and 5min.The results are shown in Table 1.This Medications Example 1, embodiment 2 all can make that white mice cough latent period obviously extends, number of times of coughing obviously reduces, and all have statistical significance with blank group comparing difference, and in certain dose-effect relationship, show that this medicine has good antitussive action.

This medicine of table 1 on white mice ammonia draw cough impact ( n=10)

Compare with normal saline group: * P<0.05, * * P<0.01

(2) reduce phlegm

By observing the impact of this medicine on white mice phenol red output, evaluate the resolve phlegm effect of this medicine.White mice divides 5 groups, is respectively this Medications Example 1, embodiment 2, embodiment 3, positive drug control group: ammonium chloride group (10g/kg) and blank group, be disposable gastric infusion, and matched group is given and waited capacity distilled water.After administration 1h, give the phenol red normal saline solution of mice by intraperitoneal injection 5% respectively, the every 20g body weight 0.5ml of volume injected, after injecting phenol red 30min, cervical dislocation puts to death white mice, is separated trachea, inserts syringe, connect to prick and fix, with 5% sodium bicarbonate lavation white mice trachea-bronchial epithelial cell, continuous 4 times, each 0.5ml, collect irrigating solution, measure absorbance with 722 type spectrophotometers at wavelength 546nm place, obtain the phenol red output of every white mice according to standard curve, compare between organizing.The results are shown in Table 2.This Medications Example 1, embodiment 2 and embodiment 3 all can make white mice phenol red output increase, and all have statistical significance, and in certain dose-effect relationship, illustrate that this medical instrument has good phlegm-dispelling functions with blank group comparing difference.

This medicine of table 2 on the impact of white mice phenol red output ( n=10)

Group	Phenol red concentration (mg/ml)
		Blank group	1.34±0.21
Embodiment 1	2.79±0.54**
		Embodiment 2	2.65±0.43**
Embodiment 3	2.54±0.46**
		Ammonium chloride (1.0g/kg)	2.96±0.61

Compare with blank group: expect P<0.01

Model case:

In through curing with this prescription 100 routine patients, wherein man 48 example, female 52 example is the course of disease the shortest half a year, the longest 12 years.

Efficacy determination: adopt 4 grade standards

Recovery from illness clinical improvements rate >96%

Effective clinical improvements rate <96%

Effective clinical improvement rate <63%

Invalid clinical improvements rate <17%

Therapeutic outcome statistics is in table 3.

Table 3

	Recovery from illness (routine %)	Effective (routine %)	Effectively (routine %)	Invalid (routine %)	Effective percentage (%)
						Latter 1 week for the treatment of	22(22)	31(31)	34(34)	13(13)	87
Latter 2 weeks for the treatment of	58(58)	23(23)	12(12)	7(7)	93
						Latter 3 weeks for the treatment of	79(79)	7(7)	9(9)	5(5)	95
Latter 4 weeks for the treatment of	96(96)	2(2)	1(1)	1(1)	99

By shown in table 3, one of the present invention treat bronchitic Chinese medicine composition its to treat bronchitic cure rate be 96%, effective cure rate is 99%.

Success case:

Feng, cotton mill, Weifang City workman, suffers from bronchitis, within the next few days because of flu cough with asthma, uncomfortable in chest, coughs yellow-white and glues expectorant.After taking a course for the treatment of of this medicine, symptom alleviates, and situation uncomfortable in chest disappears substantially, fully recovers after taking two courses for the treatment of.

Zheng, Kuiwen District, Weifang City office worker, i.e. cough with asthma of throughout the year suffering from cold is felt suffocated, and after taking two courses for the treatment of of this medicine, symptom disappears substantially, and recovery from illness after two weeks, follows up a case by regular visits to 1 year without recurring.

Chen, Qingzhou City Wang Fen town peasant, occasionally has the symptoms such as cough, abundant expectoration, asthma, is diagnosed as bronchitis, takes transference cure after a course for the treatment of of this medicine, adds again a course for the treatment of, fully recover because of worried.

Huang, Qingzhou City company clerk, low grade fever, coughs yellow sticky expectorant more than 50 sky, obstinate, takes condition after two courses for the treatment of of this medicine.

Claims

1. treat a bronchitic Chinese medicine composition, it is characterized in that: said composition is made up of following component: Fel Serpentis 3-8 gram, Rhizoma Pinelliae 8-12 gram, Herba Ephedrae 3-8 gram, Fructus Forsythiae 3-8 gram, Folium Isatidis 3-8 gram, Radix Isatidis 3-8 gram, Herba Patriniae 10-20 gram, Radix Platycodonis 8-12 gram, Cortex Mori 8-12 gram, Radix Glycyrrhizae 8-12 gram, Radix Scrophulariae 8-12 gram, Rhizoma Dioscoreae 8-12 gram, Radix Ophiopogonis 3-8 gram, Rhizoma Coptidis 3-8 gram, Semen Coicis 10-20 gram, Semen Armeniacae Amarum 8-12 gram, Herba Menthae 3-8 gram, Bulbus Fritillariae Cirrhosae 8-12 gram.

2. the bronchitic Chinese medicine composition for the treatment of according to claim 1, is characterized in that: said composition is made up of following component:

Fel Serpentis 3 grams, the Rhizoma Pinelliae 8 grams, 3 grams, Herba Ephedrae, Fructus Forsythiae 3 grams, Folium Isatidis 3 grams, Radix Isatidis 3 grams, Herba Patriniae 10 grams, Radix Platycodonis 8 grams, Cortex Mori 8 grams, 8 grams, Radix Glycyrrhizae, Radix Scrophulariae 8 grams, Rhizoma Dioscoreae 8 grams, Radix Ophiopogonis 3 grams, Rhizoma Coptidis 3 grams, Semen Coicis 10 grams, 8 grams, Semen Armeniacae Amarum, Herba Menthae 3 grams, Bulbus Fritillariae Cirrhosae 8 grams.

3. the bronchitic Chinese medicine composition for the treatment of according to claim 1, is characterized in that: said composition is made up of following component: