CN107744554A - A kind of pharyngitis mouth-sucking tablet and preparation method thereof - Google Patents
A kind of pharyngitis mouth-sucking tablet and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of pharyngitis mouth-sucking tablet and preparation method thereof, is related to technical field of traditional Chinese medicines.A kind of pharyngitis mouth-sucking tablet, mainly it is made up of following raw material：20~40 parts of great Ye delicate fragrance osmanthus, 10~20 parts of Poria cocos, 5~15 parts of radix scrophulariae, 10~20 parts of great burdock achene, 10~20 parts of Oroxylum indicum, 10~20 parts of dried orange peel, 5~15 parts of borneol, 5~15 parts of rhizoma cyperi, 5~15 parts of dandelion, 5~15 parts of radix glycyrrhizae, 5~15 parts of peppermint.With the characteristics of quick, good effect, cure rate is high.A kind of preparation method of pharyngitis mouth-sucking tablet, including：By great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint drying, crush, radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are subjected to solvent extraction, medicinal powder, extraction product are mixed with excipient, it is tabletted.The preparation method is simple and easy, workable, is easy to industrialized production.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and more particularly to a kind of pharyngitis mouth-sucking tablet and preparation method thereof.
Background technology
Sphagitis is a kind of common and multiple diseases, is specifically divided into acute and chronic two class, common performance symptom is in
It is now to have sore throat, swallow uncomfortable, hoarseness or have foreign body sensation.Its cause of disease of causing a disease is broadly divided into：Virus and bacteria infects, thing
Physicochemical factor such as high temperature, dust, smog, irritative gas etc.；In addition with bad life, eating habit etc..Laryngeal
Medicine is divided by the demand of consumer groups on the market, is generally divided into two kinds of therapeutic type and health.Therapeutic type includes Chinese patent drug and change
The major class of medicine two is learned, is mainly used in the disease for having manifest symptom that treatment triggers by flu or sphagitis.Non-therapeutic type is mainly
Health products and food, generally face because of excessive drinking and smoking or improper diet, excessive with throat, the lighter crowd of throat symptom.
Current treatment method is predominantly taken medicine, and western medicine pharyngitis is mainly antibiotics, thin to tissue
Born of the same parents' destructiveness is very strong, while antibiotic also has the very strong resistance to the action of a drug, and effect reduces after taking repeatedly；Chinese medicine for it is general,
Initial stage, pharyngitis symptom had mitigation, but was not easy to cure, medicining cycle length.
The content of the invention
The characteristics of it is an object of the invention to provide a kind of pharyngitis mouth-sucking tablet, has quick, good effect, and cure rate is high.
Another object of the present invention is to provide a kind of preparation method of pharyngitis mouth-sucking tablet, the preparation method is simple and easy, can
Strong operability, it is easy to industrialized production.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of pharyngitis mouth-sucking tablet, counts, is mainly made up of following raw material in parts by weight：Great Ye delicate fragrance osmanthus 20~
40 parts, 10~20 parts of Poria cocos, 5~15 parts of radix scrophulariae, 10~20 parts of great burdock achene, 10~20 parts of Oroxylum indicum, 10~20 parts of dried orange peel, borneol
5~15 parts, 5~15 parts of rhizoma cyperi, 5~15 parts of dandelion, 5~15 parts of radix glycyrrhizae, 5~15 parts of peppermint.
The present invention proposes a kind of preparation method of pharyngitis mouth-sucking tablet, including：By great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and
Peppermint is dry, crushes, and radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are carried out into solvent extraction, by medicinal powder, extraction product with assigning
Shape agent mixes, tabletted.
A kind of beneficial effect of pharyngitis mouth-sucking tablet of the embodiment of the present invention and preparation method thereof is：
The present invention is studied with reference to modern medicines, and the prescription of science is formed with reference to clinical experience, and the prescription has " Sweeling-eliminating medicine powder
The effect of knot, antimicrobial antiphlogistic, removing heat from the lung and relieving sorethroat ", great Ye delicate fragrance osmanthus, Poria cocos, radix scrophulariae, great burdock achene, Oroxylum indicum, dried orange peel, borneol, perfume (or spice)
Attached, dandelion, radix glycyrrhizae and peppermint are compatible, have the function that Synergistic, radix glycyrrhizae coordinating the drug actions of a prescription, auxiliary are clearing heat and detoxicating.The group
By changing the permeability of blood vessel, the water suppressed in blood is seeped into tissue for side, plays a part of detumescence, while the prescription can be with
Immunocompetence is improved, antibacterial using self immune system anti-inflammatory, snap action is in pharyngeal.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase
Product.
A kind of pharyngitis mouth-sucking tablet of the embodiment of the present invention and preparation method thereof is specifically described below.
A kind of pharyngitis mouth-sucking tablet provided in an embodiment of the present invention, is counted in parts by weight, is mainly made up of following raw material：Great Ye is clear
20~40 parts of fragrant osmanthus, 10~20 parts of Poria cocos, 5~15 parts of radix scrophulariae, 10~20 parts of great burdock achene, 10~20 parts of Oroxylum indicum, dried orange peel 10~
20 parts, 5~15 parts of borneol, 5~15 parts of rhizoma cyperi, 5~15 parts of dandelion, 5~15 parts of radix glycyrrhizae, 5~15 parts of peppermint.
Preferably, great Ye delicate fragrance osmanthus can be 21 parts, 24 parts, Poria cocos can be 11 parts, 19 parts, radix scrophulariae can be 6 parts, 7
Part, 13 parts, great burdock achene can be 11 parts, 19 parts, Oroxylum indicum can be 11 parts, 19 parts, dried orange peel can be 11 parts, 18 parts, borneol
It can be 7 parts, 13 parts, rhizoma cyperi can be 6 parts, 13 parts, and dandelion can be 9 parts, 13 parts, and radix glycyrrhizae can be 7 parts, 13 parts, thin
Lotus can be 6 parts, 7 parts, 14 parts.
Further, in the present invention preferably embodiment, count in parts by weight, raw material includes：Great Ye delicate fragrance osmanthus 25~
35 parts, 12~18 parts of Poria cocos, 8~12 parts of radix scrophulariae, 12~18 parts of great burdock achene, 12~18 parts of Oroxylum indicum, 13~17 parts of dried orange peel, borneol
8~12 parts, 8~12 parts of rhizoma cyperi, 8~12 parts of dandelion, 8~12 parts of radix glycyrrhizae, 8~12 parts of peppermint.
Preferably, great Ye delicate fragrance osmanthus can be 27 parts, 29 parts, 31 parts, 33 parts, 34 parts, Poria cocos can be 13 parts, 14 parts,
16 parts, 17 parts, radix scrophulariae can be 9 parts, 11 parts, great burdock achene can be 13 parts, 14 parts, 16 parts, Oroxylum indicum can be 14 parts, 16
Part, 17 parts, dried orange peel can be 14 parts, 16 parts, and borneol can be 9 parts, 11 parts, and rhizoma cyperi can be 9 parts, 11 parts, and dandelion 8 can be with
For 9 parts, 11 parts, radix glycyrrhizae can be 9 parts, 11 parts, and peppermint can be 10 parts, 11 parts.
Doctor trained in Western medicine thinks that pharyngitis is that mucous layer is in chronic congestion, has local telangiectasis, there is more leaching around blood vessel
Bar cellular infiltration, also can be by leucocyte or plasmocyte infiltrating.Its mucous membrane and submucosa connective tissue hyperplasia, mucosal gland increase
Raw, its secreting function is hyperfunction, causes mucous secretion to increase.
The traditional Chinese medical science thinks that pharyngitis has hot and suffocating dry throat, the mistake of deficiency of Yin throat to moisten, deficiency of vital energy throat loses foster, the warm, blood of deficiency of yang throat mistake
Stasis of blood throat, phlegm coagulate the types such as throat.In a word, in the traditional Chinese medical science " cure the disease and effect a permanent cure ", only healthy tendency are deposited, immunologic function is improved and could cured.
Great Ye delicate fragrance osmanthus, also referred to as Buxaceae, it is Buxaceae Sarcococca plant.It is among the people to promoting blood circulation and removing blood stasis, anti-inflammatory
Analgesic, and the anti-inflammatory analgetic of abscess of throat, anemopyretic cold.Ability with hemostasis, lifting macrophage phagocytosis clot, simultaneously
With raising immunity, the effect of resistance building.
Poria cocos, it is sweet, light, put down.The thoughts of returning home, lung, spleen, kidney channel.With clearing damp and promoting diuresis, the effect of invigorating the spleen calming heart.For treating water
Swollen, phlegm and retained fluid and insufficiency of the spleen.Poria cocos mild in medicine property and, Li Shui is without hindering healthy tendency.
Radix scrophulariae, it is sweet, bitter, salty, it is slightly cold.Return lung, stomach, kidney channel.With clearing heat and cooling blood, the effect of detoxicating and resolving a mass.To promotion office
Portion's blood circulation has certain effect so as to diminish inflammation.
Great burdock achene, it is pungent, bitter, tremble with fear.Attach to the lung and stomach meridians.With removing toxic substances relieving sore-throat, the effect of dispelling wind and heat from the body.
Oroxylum indicum, bitter is cold in nature, Return liver, Liver Channel.Can removing heat from the lung and relieving sorethroat, expelling pus and promoting granulation, for treating abscess of throat, branch gas
Guan Yan, cough, can also dissolving phlegm.
Dried orange peel, bitter, pungent, temperature.Return liver, the spleen channel.With regulating qi-flowing for strengthening spleen, it is eliminating dampness and eliminating phlegm the effect of.Contained volatile oil has passively
The effect of eliminating the phlegm, make the easy expectoration of sputum.There is faint dilating effect to bronchus.
Borneol, also known as borneol, it is pungent, bitter, it is slightly cold.The thoughts of returning home, spleen, lung channel.With antibacterial, the effect of clearing away heat to and alleviating pain,
Rhizoma cyperi, pungent, slight bitter, micro-sweet, put down.Return liver, spleen, tri-jiao channel.The effect of with regulating the flow of QI to ease the stomach, detumescence.Contained by rhizoma cyperi
Rhizoma Cyperi volatile oil there is bacteriostasis.
Dandelion, it is bitter, sweet, tremble with fear.Return liver, stomach.With clearing heat and detoxicating, the effect of dispersing swelling and dissipating binds.Radix glycyrrhizae, it is sweet, put down.Return
The heart, lung, spleen, stomach.With clearing heat and detoxicating, invigorate the spleen and benefit qi, the effect of expelling phlegm and arresting coughing.Radix glycyrrhizae also has anti-inflammation, reconciles all
The effect of medicine.
Peppermint, it is pungent, it is cool.Return liver, lung channel.The effect of with wind-dispelling heat-dissipating, relieving sore-throat.The tea naphthols acid that peppermint contains is effective
Antiinflammatory, there is anti-inflammatory.
Great Ye delicate fragrance osmanthus, Poria cocos, radix scrophulariae, great burdock achene, Oroxylum indicum, dried orange peel, borneol, rhizoma cyperi, dandelion, radix glycyrrhizae and peppermint phase
Compatibility, there is Synergistic, dispersing swelling and dissipating binds, antimicrobial antiphlogistic, removing heat from the lung and relieving sorethroat, radix glycyrrhizae coordinating the drug actions of a prescription, auxiliary are clearing heat and detoxicating.
By changing the permeability of blood vessel, the water suppressed in blood is seeped into tissue the prescription, plays a part of detumescence, while the prescription
Immunocompetence can be improved, antibacterial using self immune system anti-inflammatory, snap action is in pharyngeal.
Further, in the present invention preferably embodiment, count in parts by weight, 30 parts of great Ye delicate fragrance osmanthus, 15 parts of Poria cocos,
10 parts of radix scrophulariae, 15 parts of great burdock achene, 13 parts of Oroxylum indicum, 13 parts of dried orange peel, 8 parts of borneol, 8 parts of rhizoma cyperi, 10 parts of dandelion, 10 parts of radix glycyrrhizae,
10 parts of peppermint.
Provided by the invention is a kind of pharyngitis mouth-sucking tablet, and raw material also includes medicinal excipient, and excipient includes filler, profit
At least one of humectant and flavouring.Specifically, at least one of mannitol, maltodextrin and Icing Sugar, wetting agent can
Think water, ethanol or ethanol water, flavouring can be Sucralose or stevioside etc., and excipient also includes lubricant, such as sliding
Stone flour or magnesium stearate etc..Preferably, the quality of excipient is the 1~3% of material quality, can both ensure the medicine of pharyngitis mouth-sucking tablet
Effect, the taste of lozenge can be improved again.
Present invention also offers a kind of preparation method of pharyngitis mouth-sucking tablet, including：
Raw material is weighed in proportion, is cleaned.
Great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint are crushed.It is more excellent in order to strengthen absorption of the human body to medicine
, by raw material under conditions of 40~60 DEG C dry 4~6 hours, use superfine communication technique by raw material be crushed to 800 mesh with
On.
Radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are extracted into active principle using the method for water extraction.Specifically, will be profound
Ginseng, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are placed in water 20~30min of immersion, and the dosage of general water did not had 2~3cm of medicinal material to be
Preferably；Cold water is generally 0~30 DEG C.Boiled with high heat after immersion, then with being cooked by slow fire 25~35 minutes, filter the first filtrate and
The dregs of a decoction；Wherein, intense fire is 300~400 DEG C, and slow fire is 130~170 DEG C.By the dregs of a decoction plus water, general plus water amount there was not medicinal material 1
~2cm is advisable, and the second filtrate is filtered to obtain with being cooked by slow fire 15~25 minutes again after boiling with high heat；Merge the first filtrate, second
Filtrate obtains extract solution.Extract solution is boiled with high heat, and with concentration is cooked by slow fire, preferably, the relative density for extracting product is 1.13
~1.17.
Carry and take in order to facilitate patient, medicinal powder, extraction product are mixed with excipient, it is tabletted as required
Agent.And tablet can improve the compliance of patient, preferably ensure clinical efficacy.Through drying process, test package, obtain into
Product.
The preparation method of the pharyngitis mouth-sucking tablet, by the way of medicinal material beats powder and medicine is made in the mode of water effective component extracting
Agent, the active ingredient in lozenge is improved, improve drug effect.Lozenge relies primarily on oral cavity and pharyngeal mucosal absorption, medicine directly act on
In patient affected part, local concentration is high, rapid-action.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of pharyngitis mouth-sucking tablet is present embodiments provided, is made by following preparation method：
Count in parts by weight, weigh 23 parts of great Ye delicate fragrance osmanthus, 11 parts of Poria cocos, 5 parts of radix scrophulariae, 10 parts of great burdock achene, Oroxylum indicum 10
Part, 20 parts of dried orange peel, 5 parts of borneol, 5 parts of rhizoma cyperi, 5 parts of dandelion, 5 parts of radix glycyrrhizae, 5 parts of peppermint.
Great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint are dried 6 hours under conditions of 40 DEG C, using Ultramicro-powder
Raw material is crushed to 850 mesh by broken technology.
Radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are placed in water immersion 30min, boiled with high heat after immersion, then
With being cooked by slow fire 25 minutes, the first filtrate and the dregs of a decoction are filtered to obtain；By the dregs of a decoction plus water, general plus water amount there was not 1~2cm of medicinal material to be
Preferably, the second filtrate is filtered to obtain after boiling with high heat with being cooked by slow fire 25 minutes again；Merge the first filtrate, the second filtrate must extract
Liquid.Extract solution is boiled with high heat, and relative density is concentrated into as 1.13 with being cooked by slow fire.
Medicinal powder, extraction product are mixed with quality for the excipient of raw material 1%, it is tabletted as required.Through drying
Processing, test package, obtain finished product.
Embodiment 2
A kind of pharyngitis mouth-sucking tablet is present embodiments provided, is made by following preparation method：
Count in parts by weight, weigh 40 parts of great Ye delicate fragrance osmanthus, 20 parts of Poria cocos, 15 parts of radix scrophulariae, 10 parts of great burdock achene, Oroxylum indicum 10
Part, 10 parts of dried orange peel, 8 parts of borneol, 11 parts of rhizoma cyperi, 12 parts of dandelion, 12 parts of radix glycyrrhizae, 7 parts of peppermint.
Great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint are dried 5 hours under conditions of 50 DEG C, using Ultramicro-powder
Raw material is crushed to 800 mesh by broken technology.
Radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are placed in water immersion 20min, boiled with high heat after immersion, then
With being cooked by slow fire 25 minutes, the first filtrate and the dregs of a decoction are filtered to obtain；By the dregs of a decoction plus water, general plus water amount there was not 1~2cm of medicinal material to be
Preferably, the second filtrate is filtered to obtain after boiling with high heat with being cooked by slow fire 15 minutes again；Merge the first filtrate, the second filtrate must extract
Liquid.Extract solution is boiled with high heat, and relative density is concentrated into as 1.17 with being cooked by slow fire.
Medicinal powder, extraction product are mixed with quality for the excipient of raw material 3%, it is tabletted as required.Through drying
Processing, test package, obtain finished product.
Embodiment 3
A kind of pharyngitis mouth-sucking tablet is present embodiments provided, is made by following preparation method：
Count in parts by weight, weigh 25 parts of great Ye delicate fragrance osmanthus, 12 parts of Poria cocos, 12 parts of radix scrophulariae, 12 parts of great burdock achene, Oroxylum indicum 18
Part, 14 parts of dried orange peel, 8 parts of borneol, 8 parts of rhizoma cyperi, 8 parts of dandelion, 12 parts of radix glycyrrhizae, 12 parts of peppermint.
Great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint are dried 4 hours under conditions of 40 DEG C, using Ultramicro-powder
Raw material is crushed to 900 mesh by broken technology.
Radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are placed in water immersion 20min, boiled with high heat after immersion, then
With being cooked by slow fire 25 minutes, the first filtrate and the dregs of a decoction are filtered to obtain；By the dregs of a decoction plus water, general plus water amount there was not 1~2cm of medicinal material to be
Preferably, the second filtrate is filtered to obtain after boiling with high heat with being cooked by slow fire 15 minutes again；Merge the first filtrate, the second filtrate must extract
Liquid.Extract solution is boiled with high heat, and relative density is concentrated into as 1.13 with being cooked by slow fire.
Medicinal powder, extraction product are mixed with quality for the excipient of raw material 3%, it is tabletted as required.Through drying
Processing, test package, obtain finished product.
Embodiment 4
A kind of pharyngitis mouth-sucking tablet is present embodiments provided, is made by following preparation method：
Count in parts by weight, weigh 35 parts of great Ye delicate fragrance osmanthus, 12 parts of Poria cocos, 8 parts of radix scrophulariae, 18 parts of great burdock achene, Oroxylum indicum 12
Part, 13 parts of dried orange peel, 12 parts of borneol, 12 parts of rhizoma cyperi, 8 parts of dandelion, 8 parts of radix glycyrrhizae, 8 parts of peppermint.
Great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint are dried 4 hours under conditions of 60 DEG C, using Ultramicro-powder
Raw material is crushed to 800 mesh by broken technology.
Radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are placed in water immersion 20min, boiled with high heat after immersion, then
With being cooked by slow fire 35 minutes, the first filtrate and the dregs of a decoction are filtered to obtain；By the dregs of a decoction plus water, general plus water amount there was not 1~2cm of medicinal material to be
Preferably, the second filtrate is filtered to obtain after boiling with high heat with being cooked by slow fire 15 minutes again；Merge the first filtrate, the second filtrate must extract
Liquid.Extract solution is boiled with high heat, and relative density is concentrated into as 1.14 with being cooked by slow fire.
Medicinal powder, extraction product are mixed with quality for the excipient of raw material 2%, it is tabletted as required.Through drying
Processing, test package, obtain finished product.
Embodiment 5
A kind of pharyngitis mouth-sucking tablet is present embodiments provided, is made by following preparation method：
Count in parts by weight, weigh 30 parts of great Ye delicate fragrance osmanthus, 15 parts of Poria cocos, 10 parts of radix scrophulariae, 15 parts of great burdock achene, Oroxylum indicum 13
Part, 13 parts of dried orange peel, 8 parts of borneol, 8 parts of rhizoma cyperi, 10 parts of dandelion, 10 parts of radix glycyrrhizae, 10 parts of peppermint.
Great Ye delicate fragrance osmanthus, Poria cocos, borneol, dandelion and peppermint are dried 5 hours under conditions of 50 DEG C, using Ultramicro-powder
Raw material is crushed to 1000 mesh by broken technology.
Radix scrophulariae, great burdock achene, Oroxylum indicum, rhizoma cyperi and radix glycyrrhizae are placed in water immersion 20min, boiled with high heat after immersion, then
With being cooked by slow fire 30 minutes, the first filtrate and the dregs of a decoction are filtered to obtain；By the dregs of a decoction plus water, general plus water amount there was not 1~2cm of medicinal material to be
Preferably, the second filtrate is filtered to obtain after boiling with high heat with being cooked by slow fire 20 minutes again；Merge the first filtrate, the second filtrate must extract
Liquid.Extract solution is boiled with high heat, and relative density is concentrated into as 1.15 with being cooked by slow fire.
Medicinal powder, extraction product are mixed with quality for the excipient of raw material 2%, it is tabletted as required.Through drying
Processing, test package, obtain finished product.
Comparative example 1
This comparative example provides a kind of pharyngitis mouth-sucking tablet, is made by following preparation method：
Count in parts by weight, weigh 13 parts of dried orange peel, 10 parts of dandelion, 10 parts of radix glycyrrhizae, 10 parts of peppermint.
Dried orange peel, dandelion, radix glycyrrhizae and peppermint are dried 4 hours under conditions of 40 DEG C, using superfine communication technique by original
Feed powder is broken to 800 mesh.
Medicinal powder is mixed with quality for the excipient of raw material 1%, it is tabletted as required.Through drying process, examine
Packaging, obtains finished product.
The zoopery of test example 1
1. Animal Model
The qualified cleaning grade Kunming mouse 160 of health is chosen, male and female half and half, 18~22g of body weight, is randomly divided into 8 groups.
2. medicine feed
The pharyngitis mouth-sucking tablet that embodiment 1~5 and comparative example 1 are provided crushes, and after the sieving of 120 mesh, weighs and is dissolved in right amount
In 0.5% carboxymethylcellulose sodium solution, 0.15g/ml suspension is made into, dexamethasone acetate tablets are crushed, is dissolved in 0.5%
In carboxymethylcellulose sodium solution, 19.8 μ g/ml suspension is made into.Respectively to 1~6 group of mouse feeding embodiment 1~5, right
Turbid solution corresponding to ratio 1, to the suspension of 7 groups of mouse feeding dexamethasone acetate tablets.Same dose is fed to 8 groups of mouse
Physiological saline.Gavage medicine twice daily.
3. experiment
After administration 3 days, it is administered once by same procedure, after 30min, before the painting of 0.05ml dimethylbenzene and each group mouse right ear
Two sides afterwards, coating is not used as control to left ear.To scorching 40min, mouse cervical dislocation is put to death, left and right ear is cut, uses card punch
The equal position auricle of ears is taken, is weighed.The difference of left and right ear weight is swelling, classified statistics, t inspections is carried out between group, by following
Formula calculates by reagent swelling inhibiting rate：Swelling inhibiting rate=(the average swelling of the average swelling-administration group of normal group)/normal
Average swelling × 100% of group.
4. result and analysis
The experimental result of table 1
| Swelling (g) | Swelling inhibiting rate (%) | |
| Embodiment 1 | 0.0072±0.0022 | 35.9 |
| Embodiment 2 | 0.0071±0.0028 | 36.1 |
| Embodiment 3 | 0.0064±0.0042 | 50.0 |
| Embodiment 4 | 0.0063±0.0042 | 50.1 |
| Embodiment 5 | 0.0055±0.0022 | 56.3 |
| Comparative example 1 | 0.0114±0.0028 | 18.5 |
| Control group | 0.0101±0.0034 | 20.0 |
| Blank group | 0.0127±0.0041 |
As shown in Table 1, compared with blank group, other inhibited to mouse swelling, swelling of embodiment 1~5 of group
Inhibiting rate is above comparative example 1 and control group, and the swelling inhibiting rate of wherein embodiment 5 is higher, illustrates its pharyngitis mouth-sucking tablet provided
Antiinflammatory action it is preferable.
The zoopery of test example 2
1. Animal Model
The qualified cleaning grade Kunming mouse 160 of health is chosen, male and female half and half, 18~22g of body weight, is randomly divided into 8 groups.
2. medicine feed
The pharyngitis mouth-sucking tablet that embodiment 1~5 and comparative example 1 are provided crushes, and after the sieving of 120 mesh, weighs and is dissolved in right amount
In 0.5% carboxymethylcellulose sodium solution, 0.15g/ml suspension is made into, dexamethasone acetate tablets are crushed, is dissolved in 0.5%
In carboxymethylcellulose sodium solution, 19.8 μ g/ml suspension is made into.Respectively to 1~6 group of mouse feeding embodiment 1~5, right
Turbid solution corresponding to ratio 1, to the suspension of 7 groups of mouse feeding dexamethasone acetate tablets.Same dose is fed to 8 groups of mouse
Physiological saline.Gavage medicine twice daily.
3. experiment
Administration 3 days after, be administered once by same procedure, after 30min, every group of animal by 0.1ml/10g through tail iv1% she
Train of thought orchid physiological saline, 0.9% glacial acetic acid is then injected intraperitoneally, 40min puts to death each animal cervical dislocation after injection, with life
Salt water washing abdominal cavity is managed, and collects cleaning solution, adjustment volume to 7ml, 3000r/min centrifugation 5min, is determined under 580nm wavelength
Absorbance.
4. result and analysis
The experimental result of table 2
As shown in Table 2, compared with blank group, the absorbance that 1~5 group of embodiment declines, and shows that embodiment 1~5 provides
Pharyngitis mouth-sucking tablet can suppress the permeability of blood vessel, the wherein absorbance of embodiment 5 illustrates the blood of its pharyngitis mouth-sucking tablet provided the bottom of compared with
The inhibition of pipe permeability is preferable.
The clinical trial of test example 3
1. case is selected in
All cases suffer from the patient of pharyngitis from certain hospital diagnosis, are selected in 150 patients, 18~60 years old age, sheet
Medicine not allergy.It is randomly divided into 5 groups, every group of 30 people, the general information such as the sex of each group patient, stadium compares, and difference is without system
Meter learns meaning (p>0.05).
2. treatment method
1~5 group of patient distinguishes the pharyngitis mouth-sucking tablet that oral embodiment 1~5 provides.It is daily oral 3~6, a Monday
The course for the treatment of, use 4 courses for the treatment of.
3. curative effect determinate standard
It is effective：The symptoms such as pharyngitis enlargement, pain substantially mitigate, and bottleneck throat is clearly better.
Take a turn for the better：The symptoms such as pharyngitis enlargement, pain have mitigated, and bottleneck throat has taken a turn for the better.
It is invalid：Without mitigation or aggravated by symptom after treatment.
4. result and analysis
From in the treatment group of medicine of the present invention, the effective percentage of embodiment 1~5 is respectively 80%, 80%, 83.3%,
83.3%th, 86.7%, the effect for the pharyngitis mouth-sucking tablet that embodiment 5 provides is preferable, efficient higher, illustrates reasonable recipe, preparation side
Method more science.
In summary, pharyngitis mouth-sucking tablet provided by the invention has the function that " dispersing swelling and dissipating binds, antimicrobial antiphlogistic, removing heat from the lung and relieving sorethroat ",
Great Ye delicate fragrance osmanthus, Poria cocos, radix scrophulariae, great burdock achene, Oroxylum indicum, dried orange peel, borneol, rhizoma cyperi, dandelion, radix glycyrrhizae and peppermint are compatible, tool
There is Synergistic, radix glycyrrhizae coordinating the drug actions of a prescription, auxiliary are clearing heat and detoxicating.The prescription suppresses blood by changing the permeability of blood vessel
Water in liquid is seeped into tissue, plays a part of detumescence, while the prescription can improve immunocompetence, utilize self immune system
Anti-inflammatory is antibacterial, and snap action is in pharyngeal.
Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of pharyngitis mouth-sucking tablet, it is characterised in that count, be mainly made up of following raw material in parts by weight：Great Ye delicate fragrance osmanthus 20~
40 parts, 10~20 parts of Poria cocos, 5~15 parts of radix scrophulariae, 10~20 parts of great burdock achene, 10~20 parts of Oroxylum indicum, 10~20 parts of dried orange peel, borneol
5~15 parts, 5~15 parts of rhizoma cyperi, 5~15 parts of dandelion, 5~15 parts of radix glycyrrhizae, 5~15 parts of peppermint.
2. pharyngitis mouth-sucking tablet according to claim 1, it is characterised in that count in parts by weight, the raw material includes：It is described big
25~35 parts of leaf delicate fragrance osmanthus, 12~18 parts of the Poria cocos, 8~12 parts of the radix scrophulariae, 12~18 parts of the great burdock achene, the wooden butterfly
12~18 parts of butterfly, 13~17 parts of the dried orange peel, 8~12 parts of the borneol, 8~12 parts of the rhizoma cyperi, the dandelion 8~12
Part, 8~12 parts of the radix glycyrrhizae, 8~12 parts of the peppermint.
3. pharyngitis mouth-sucking tablet according to claim 2, it is characterised in that count in parts by weight, the raw material includes：It is described big
30 parts of leaf delicate fragrance osmanthus, 15 parts of the Poria cocos, 10 parts of the radix scrophulariae, 15 parts of the great burdock achene, 13 parts of the Oroxylum indicum, the dried orange peel
13 parts, 8 parts of the borneol, 8 parts of the rhizoma cyperi, 10 parts of the dandelion, 10 parts of the radix glycyrrhizae, 10 parts of the peppermint.
4. pharyngitis mouth-sucking tablet according to claim 1, it is characterised in that the pharyngitis mouth-sucking tablet also includes medicinal excipient,
The excipient includes at least one of filler, wetting agent and flavouring.
5. pharyngitis mouth-sucking tablet according to claim 4, it is characterised in that the excipient includes filler, the filler
Including at least one of mannitol, maltodextrin and Icing Sugar.
6. pharyngitis mouth-sucking tablet according to claim 4, it is characterised in that the quality of the excipient is the material quality
1~3%.
A kind of 7. preparation method of pharyngitis mouth-sucking tablet as described in any one of claim 1~6, it is characterised in that including：By described in
Great Ye delicate fragrance osmanthus, the Poria cocos, the borneol, the dandelion and the peppermint are dry, crush, by the radix scrophulariae, the ox
Burdock, the Oroxylum indicum, the rhizoma cyperi and the radix glycyrrhizae carry out solvent extraction, and medicinal powder, extraction product are mixed with excipient, pressed
Tablet is made.
8. the preparation method of pharyngitis mouth-sucking tablet according to claim 7, it is characterised in that using superfine communication technique by described in
Great Ye delicate fragrance osmanthus, the Poria cocos, the borneol, the dandelion and the peppermint are crushed to more than 800 mesh.
9. the preparation method of pharyngitis mouth-sucking tablet according to claim 7, it is characterised in that the method for solvent extraction includes：Will
The radix scrophulariae, the great burdock achene, the Oroxylum indicum, the rhizoma cyperi and the radix glycyrrhizae mix with water, after decocting extraction, concentration extraction
Liquid.
10. the preparation method of pharyngitis mouth-sucking tablet according to claim 9, it is characterised in that the extraction production by concentration
The relative density of thing is 1.13~1.17.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108635310A (en) * | 2018-08-14 | 2018-10-12 | 海南金香远药业科技有限公司 | Inflammation-diminishing toothpaste and preparation method thereof |
| CN109480028A (en) * | 2019-01-01 | 2019-03-19 | 孟九任 | A kind of prebiotic tea and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631425A (en) * | 2004-12-02 | 2005-06-29 | 李佩服 | Lozenge for treating its pharyngitis and preparation process thereof |
| CN103055130A (en) * | 2013-02-17 | 2013-04-24 | 张洪君 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
-
2017
- 2017-11-30 CN CN201711245076.0A patent/CN107744554A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631425A (en) * | 2004-12-02 | 2005-06-29 | 李佩服 | Lozenge for treating its pharyngitis and preparation process thereof |
| CN103055130A (en) * | 2013-02-17 | 2013-04-24 | 张洪君 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 朱兆云等: "《云南天然药物图鉴》", 28 February 2012, 云南科技出版社 * |
| 王士贞等: "《中医耳鼻咽喉科学》", 31 March 2017, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108635310A (en) * | 2018-08-14 | 2018-10-12 | 海南金香远药业科技有限公司 | Inflammation-diminishing toothpaste and preparation method thereof |
| CN109480028A (en) * | 2019-01-01 | 2019-03-19 | 孟九任 | A kind of prebiotic tea and preparation method thereof |
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Application publication date: 20180302 |