CN103356891B - Sugar-free throat-clearing lozenge and preparation method thereof - Google Patents
Sugar-free throat-clearing lozenge and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a sugar-free throat-clearing lozenge and a preparation method thereof. The preparation method comprises that trollflower, platycodon grandiflorum, lily, polygonatum odoratum and liquorice as raw materials are orderly subjected to extraction, filtration, condensation, and excipient, flavoring and lubricant addition processes to form the sugar-free throat-clearing lozenge having health care effects. The sugar-free throat-clearing lozenge has a simple and reasonable formula, contains all traditional Chinese medicines, has synergistic effects of dispelling wind and clearing heat, nourishing yin and discharging fire, and removing toxins and relieving sore-throat, can produce the health care functions of clearing and nourishing throat, has good stability and a high product yield, adopts main and auxiliary materials without cane sugar, and is suitable for diabetes patients. The preparation method has simple processes and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of Chinese medicine class health product, particularly relate to a kind of health product of sugar-free guttural tablets class
Background technology
Along with improving constantly of living standard, the health care consciousness of people is also strengthening day by day, which constitute the large good environment of China's health product development, the annual turnover of health product once increased progressively with the amount of increase of 30%-50%, Chinese medicine class health product, as the important component part of healthy consumption, just become the consumption growth point with the absolute advantages of " green, back to nature ".Laryngeal medicine, health product become one of maximum Medicines and Health Product of consumption after stomach medicine, coldrex.Because throat and oral disease belong to frequently-occurring disease and commonly encountered diseases, waiting a moment property pharyngolaryngitis symptom is difficult to thorough elimination, and this just makes throat oral health-care product and medication have the huge consumer group and wide market development space.
Buccal tablet is the dosage form of cleaning throat and moistening larynx product main flow, its advantage is mainly manifested in: the consumer objects of general cleaning throat and moistening larynx product is patients with chronic pharyngitis, have the symptoms such as throat is itched, twinge, dry cough, the not too suitable product needing to swallow, as capsule, peroral tablets; Buccal tablet can the long time, directly act on affected part, effectiveness comparison is good, and tea, beverage to the adjustment of health entirety and prevention throat discomfort effectiveness comparison desirable, but moment comfortable effect not as good as buccal tablet; In addition, buccal tablet form also has the advantage of carrying, conveniently taking, and is applicable to the rhythm of life of modern, therefore more has popular basis.
Summary of the invention
The object of this invention is to provide a kind of formula to simplify, rationally, and be applicable to diabetics and take, play the sugar-free guttural tablets of effects of clearing and nourishing throat, to solve problems of the prior art.
Another object of the present invention is to provide a kind of preparation method of above-mentioned sugar-free guttural tablets.
Sugar-free guttural tablets of the present invention comprises following composition, is respectively by weight percentage:
Flos Trollii 1-20 part, Radix Platycodonis 1-20 part, Bulbus Lilii 1-20 part, Rhizoma Polygonati Odorati 1-20 part, Radix Glycyrrhizae 1-10 part, Sorbitol 20-80 part, Mentholum 0.1-0.5 part, aspartame 0.04-0.12 part, citric acid 0.2-1.0 part, magnesium stearate 0.2-0.5 part.
In wherein said buccal tablet composition, Sorbitol is excipient, can be replaced by different ratio such as soluble starch, dextrin, lactose, mannitol, maltose; Described Mentholum 0.1-0.5 part, aspartame 0.04-0.12 part, citric acid 0.2-1.0 part are correctives, and wherein Mentholum can use Oleum menthae, Herba Menthae Haplocalycis volatile oil to replace, and Aspartane can use acesulfame potassium, stevioside to replace; Described magnesium stearate is lubricant.
This invention formula, from the hygienic measures on of the traditional Chinese medical science to cleaning throat and moistening larynx, is finally formed by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Flos Trollii nature and flavor in side, bitter, be slightly cold, clearing away heat-fire; Radix Platycodonis nature and flavor, bitter, pungent, flat, return lung meridian, lung qi dispersing, sore-throat relieving; Bulbus Lilii nature and flavor, sweet, cold, GUIXIN, lung meridian; Rhizoma Polygonati Odorati nature and flavor, sweet, be slightly cold, attach to the lung and stomach meridians, two medicines share, and promote the production of body fluid, nourshing Yin and drynsessmoistening prescription, moistening and cleaning throat and non-impairment of YIN, and also play restriction to the side effect of heat clearing and fire purging medicine; Radix Glycyrrhizae nature and flavor, sweet, flat, GUIXIN, lung, spleen, stomach warp, moistening and cleaning throat, expelling phlegm for arresting cough, and coordinating the actions of various ingredients in a prescription.Formula is simplified, rationally.All medicines share, and play wind and heat dispersing altogether, yin nourishing pathogenic fire purging, and the merit of resolving toxin and disinhibiting the throat plays the health-care effect of cleaning throat and moistening larynx.
The internal metabolism such as batching Sorbitol, aspartame of this invention does not need insulin to participate in, and is applicable to diabetes and bariatric patients; Aspartame, Mentholum, citric acid are as correctives, and wherein Mentholum is pharmaceutically having refrigerant itching-relieving action, take orally and can be used as carminative, for headache and nose, pharynx, laryngitis etc.; Citric acid has expelling phlegm for arresting cough, symptom such as treatment rhinitis, pharyngitis etc. on medical; Magnesium stearate is mainly as lubricant.
The technological process or the method step that manufacture buccal tablet of the present invention are as follows:
1, Flos Trollii adds water warm macerating (or decoct), filters, for subsequent use;
2, Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water, and filter, merge, be condensed into thick paste with above-mentioned reserve liquid;
3, add excipient appropriate, mixing, makes granule, dry;
4, add correctives, lubricant is appropriate, mixing, airtight, tabletted.
Further, the finished product of above-mentioned tabletted (also known as plain sheet) can be carried out coating, form coated tablet.
Wherein in step 1 and 2, be ensure drug effect, Flos Trollii can be taked to add water warm macerating (or decoction) 2-3 time, each warm macerating (or decoction) 40-90 minute, filtration, and filtrate is merged; Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water twice, and each decocting time is no less than 90 minutes, filter, and filtrate are merged.
Wherein in step 2, the relative density being condensed into thick paste is 1.14-1.20.
Accompanying drawing explanation
Fig. 1 is the production technological process of sugar-free guttural tablets of the present invention
Detailed description of the invention
Further describe the present invention below in conjunction with concrete embodiment, but protection scope of the present invention is not limited to this:
Embodiment 1
Formula: Flos Trollii 200g Radix Platycodonis 100g Bulbus Lilii 60g Rhizoma Polygonati Odorati 60g Radix Glycyrrhizae 50g
Sorbitol 700g, Mentholum 3g, aspartame 1g, citric acid 5g, magnesium stearate 4g
Preparation method: Flos Trollii decocts with water secondary, each 20 times of water gagings, decoct 60 minutes, and decocting liquid filters, and filtrate merges, for subsequent use; Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water secondary, each 10 times of water gagings, decoct 90 minutes, decocting liquid filters, and filtrate merges, and merges with above-mentioned reserve liquid, being concentrated into relative density is 1.18(60 DEG C), add Sorbitol, mixing, make granule, drying, it is appropriate to add magnesium stearate, citric acid, Mentholum and aspartame, mixing, airtight, tabletted, to obtain final product.
Embodiment 2
Formula: Flos Trollii 100g Radix Platycodonis 200g Bulbus Lilii 80g Rhizoma Polygonati Odorati 60g Radix Glycyrrhizae 40g
Sorbitol 800g, Mentholum 8g, aspartame 0.5g, citric acid 3g, magnesium stearate 2g
Preparation method: Flos Trollii decocts with water secondary, first time adds 24 times of water gagings, decocts 90 minutes, and second time adds 20 times of water gagings, decocts 60 minutes, and decocting liquid filters, and filtrate merges, for subsequent use; Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water three times, and 12 times of water gagings, decoct 120 minutes for the first time, second time 10 times of water gagings, decoct 90 minutes, 8 times of water gagings, decoct 60 minutes for the third time, and decocting liquid filters, filtrate merges, and merge with above-mentioned reserve liquid, being concentrated into relative density is 1.20(60 DEG C), add Sorbitol, mixing, makes granule, drying, adds magnesium stearate, citric acid, Mentholum and aspartame, mixing, airtight, tabletted, film coating, to obtain final product.
Embodiment 3
Flos Trollii 220g Radix Platycodonis 77g Bulbus Lilii 55g Rhizoma Polygonati Odorati 44g Radix Glycyrrhizae 44g
Sorbitol 750g, Mentholum 4g, aspartame 1.5g, citric acid 6g, magnesium stearate 3g
Preparation method: Flos Trollii adds water warm macerating (90 DEG C) three times, and first time adds 30 times of water gagings, warm macerating 90 minutes, and second time adds 20 times of water gagings, warm macerating 60 minutes, and third time adds 16 times of water gagings, warm macerating 45 minutes, and medicinal liquid filters, and filtrate merges, for subsequent use; Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water secondary, and 10 times of water gagings, decoct 90 minutes for the first time, second time 8 times of water gagings, decoct 60 minutes decocting liquids and filter, filtrate merges, merge with above-mentioned reserve liquid, being concentrated into relative density is 1.20(60 DEG C), add Sorbitol, mixing, makes granule, dry, add magnesium stearate, citric acid, Mentholum and aspartame, mixing, airtight, tabletted, film coating, to obtain final product.
Claims (6)
1. a sugar-free guttural tablets, is made up of following raw material, and each raw material weight number is respectively:
Flos Trollii 22 parts, Radix Platycodonis 7.7 parts, Bulbus Lilii 5.5 parts, Rhizoma Polygonati Odorati 4.4 parts, 4.4 parts, Radix Glycyrrhizae, Sorbitol 75 parts, magnesium stearate 0.3 part, Mentholum 0.4 part, aspartame 0.15 part, citric acid 0.6 part.
2. a sugar-free guttural tablets, is made up of following raw material, and each raw material weight number is respectively:
Flos Trollii 20 parts, Radix Platycodonis 10 parts, Bulbus Lilii 6 parts, Rhizoma Polygonati Odorati 6 parts, 5 parts, Radix Glycyrrhizae, Sorbitol 70 parts, magnesium stearate 0.4 part, Mentholum 0.3 part, aspartame 0.1 part, citric acid 0.5 part.
3. the manufacture method of sugar-free guttural tablets as claimed in claim 1 or 2, the method comprises following steps:
(1) Flos Trollii adds water warm macerating or decoction, filters, for subsequent use;
(2) Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water, and filter, merge, be condensed into thick paste with above-mentioned reserve liquid;
(3) add Sorbitol appropriate, mixing, makes granule, dry;
(4) add magnesium stearate, Mentholum, aspartame, citric acid is appropriate, mixing, airtight, tabletted.
4. the manufacture method of sugar-free guttural tablets as claimed in claim 3, is characterized in that after completing steps (4), then the buccal tablet of tabletted is carried out coating, be made into coated tablet.
5. the manufacture method of sugar-free guttural tablets as claimed in claim 3, it is characterized in that in step (1) and (2), described Flos Trollii is taked to add water warm macerating or decoct 2-3 time, each warm macerating or decoct 45-90 minute, filters afterwards and filtrate is merged; Described Radix Platycodonis, Bulbus Lilii, Rhizoma Polygonati Odorati, Radix Glycyrrhizae decoct with water 2-3 time, each decocting time 60-120 minute, filter rear and filtrate are merged.
6. the manufacture method of sugar-free guttural tablets as claimed in claim 3, it is characterized in that in step (2), the relative density being condensed into thick paste is 1.14-1.20.
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CN104206614A (en) * | 2014-04-26 | 2014-12-17 | 钟祥亿源生物科技有限公司 | Sugar-free Chinese herbal medicine-vegetable-fruit product having effects of clearing heat from throat and raising spirit |
CN104225196B (en) * | 2014-09-09 | 2017-04-12 | 武汉科德中医医院有限公司 | Traditional Chinese medicine effervescent tablet for treating respiratory diseases and preparation method of traditional Chinese medicine effervescent tablet |
CN104815152A (en) * | 2015-05-06 | 2015-08-05 | 山东宏济堂制药集团有限公司 | Throat-moistening and cough-relieving candy, preparation method and application thereof |
CN105193911A (en) * | 2015-09-24 | 2015-12-30 | 湖南炎帝生物工程有限公司 | Throat-clearing lozenges and preparation method thereof |
CN106389966B (en) * | 2016-11-25 | 2019-06-18 | 广东大鹏医药科技有限公司 | A kind of Chinese globeflower buccal tablets and preparation method thereof |
CN108935881A (en) * | 2018-06-29 | 2018-12-07 | 贵州苗嗓子原生态产业发展有限公司 | Using radix polygonati officinalis as throat-clearing lung-moistening functional form candy of major ingredient and preparation method thereof |
CN109125597B (en) * | 2018-08-27 | 2021-03-16 | 重庆市中药研究院 | Shaddock pulp buccal tablet and preparation method thereof |
CN109601683A (en) * | 2019-01-08 | 2019-04-12 | 广东大鹏医药科技有限公司 | A kind of trollflower dark plum larynx sugar and preparation method thereof |
CN115211485A (en) * | 2022-06-08 | 2022-10-21 | 湖北科技学院 | Sweet osmanthus buccal tablets for clearing heat from throat and moistening lung |
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