CN104840734A - Throat-clearing health-care traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Throat-clearing health-care traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a throat-clearing health-care traditional Chinese medicine composition as well as a preparation method and an application thereof. The effective components of the traditional Chinese medicine are prepared from the following raw materials in parts by weight: 20-40 parts of rehmannia, 20-40 parts of radix ophiopogonis, 20-40 parts of radix scrophulariae, 10-30 parts of honeysuckle, 10-30 parts of unibract fritillary bulb, 10-20 parts of liquorice and 10-20 parts of fructus momordicae. According to the traditional Chinese medicine composition, materials with dual-purpose drug and food and with effects of clearing away heat and toxic materials, nourishing yin and clearing away fire, helping produce saliva and slake thirst, moistening lung and expelling phlegm to arrest coughing and the like are used; the traditional Chinese medicine can be prepared into dosage forms such as oral liquid, buccal tablets or capsules, is used for treating diseases such as acute and chronic faucitis, and is particularly suitable for dry mouth and swollen sore throat resulted from heat toxin and chronic pharyngitis resulted from hyperactivity of fire due to yin deficiency and excess syndrome accompanied by deficiency syndrome.
Description
Technical field
The invention belongs to health care Chinese medicine field of pharmaceutical technology, be specifically related to a kind of moistening and cleaning throat health-care Chinese medicinal composition and its preparation method and application.
Background technology
Pharyngolaryngitis is a kind of disease caused by antibacterial or virus, can be divided into acute pharyngolaryngitis and chronic pharyngolaryngitis two kinds.Acute pharyngitis is often a part for upper respiratory tract infection, how caused by viral infection.Acute pharyngitis recurrent exerbation can transfer chronic pharyngitis to, and long-term tobacco and wine excessively or by harmful micro-tapping also can cause chronic pharyngitis.
According to theory of Chinese medical science, swallow the pass into stomach, larynx is the door of lung, and the heresy of diseases caused by exogenous pathogenic factor enters lung and easily hinders larynx, and improper diet enters stomach and is vulnerable to pharynx, and throat is the ground that evil malicious good leaching is stayed for a long time.The pharyngolaryngitis cause of disease is clinical inside and outside dividing, and exopathogenic factor mostly is the heresy be affected by the cold, the heresy of strongly fragrant heat-transformation of a specified duration or wind heat; Endogenous cause of ill mostly is the ferritic deficiency of YIN, pungently decocts stir-fry, stagnation of phlegm-heat again addicted to food, upper bright throat or with the passing of time consume the moon of impairing the lung kidney, and cause hyperactivity of deficient fire, consumption of body fluid by heat becomes expectorant, expectorant heat follow through on disturb throat, clean the street caused by failure.
Chinese traditional treatment pharyngolaryngitis, it has been generally acknowledged that all diseases of throat all belong to fire, chronic pharyngitis is relevant with fire, and this fire asthenic fire may also be excess-fire, the medicine of some YIN nourishing, dispelling wind, heat clearing away, sore-throat relieving, and to throat problems such as treatment chronic pharyngitiss, the good results are evident.Chronic pharyngitis is divided into YIN-deficiency type, deficiency of yang type, qi-deficiency type, phlegm stagnancy type etc. in the traditional Chinese medical science, but common with YIN-deficiency type.YIN-deficiency type main manifestations is pharyngeal discomfort, dry pharynx itching throat, congestion and swelling pain, and brothers' heart generates heat, dry mouth, the symptoms such as soreness of the waist and knees.
Summary of the invention
Based on this, the invention provides one and there is moistening and cleaning throat effect, be particularly useful for the health-care Chinese medicinal composition of chronic pharyngolaryngitis.
The concrete technical scheme solved the problems of the technologies described above is as follows:
A kind of moistening and cleaning throat health-care Chinese medicinal composition, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 20-40 part, Radix Ophiopogonis 20-40 part, Radix Scrophulariae 20-40 part, Flos Lonicerae 10-30 part, Bulbus Fritillariae Cirrhosae 10-30 part, Radix Glycyrrhizae 10-20 part, Fructus Momordicae 10-20 part.
Wherein in some embodiments, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 30 parts, Radix Ophiopogonis 30 parts, Radix Scrophulariae 30 parts, Flos Lonicerae 20 parts, Bulbus Fritillariae Cirrhosae 20 parts, 15 parts, Radix Glycyrrhizae, Fructus Momordicae 15 parts.
The present invention, mainly by the collaborative collocation of Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae, Flos Lonicerae, Bulbus Fritillariae Cirrhosae, Radix Glycyrrhizae, Fructus Momordicae, plays effect of pharynx-clearing throat-benefiting, reaches the object for the treatment of acute and chronic pharyngitis.
The pharmacology of each raw material of moistening and cleaning throat health-care Chinese medicinal composition of the present invention is as follows:
1, Radix Rehmanniae: cool in nature, sweet-bitter flavor, has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, for maculae caused by virulent heat pathogen, crimson tongue excessive thirst, laryngopharynx swelling and pain.The performance nourishing YIN and clearing away fire of Radix Rehmanniae, no matter the damp and hot clothes of deficiency-heat is all suitable.The Radix Rehmanniae and Radix Ophiopogonis Chang Xiangxu be use, strengthen the effect that nourishing kidney-yin relieves inflammation or internal heat, tradition is applied to hyperactivity of fire caused by deficiency of YIN, hectic fever night sweat, and xerostomia pharyngalgia, uses flexibly in recent years after Chinese medical discrimination, has good therapeutic effect to chronic pharyngitis etc.
2, Radix Ophiopogonis: sweet in the mouth, micro-hardship, cool, there is effect of nourishing YIN for benefiting the kidney, nourishing the lung to arrest cough, promoting the production of body fluid to quench thirst.Radix Ophiopogonis is used for the treatment of chronic pharyngitis clinically, excellent to curative effects such as chronic pharyngitis pharyngeal pain, drying, restlessness and thirst, hoarseness.Have share Radix Scrophulariae and Radix Ophiopogonis the effect of good YIN nourishing sore-throat relieving, have Radix Scrophulariae and Radix Ophiopogonis effect of yin nourishing, nourishing kidney-yin is partial to by Radix Scrophulariae, and can rush down asthenic fire again, it is dry that Radix Ophiopogonis is partial to lung moistening, is usually used in dry cough, spitting of blood, pharyngalgia etc. that the dryness of the lung or asthenic fire cause.By the Radix Scrophulariae of nourishing yin and purging fire and the chronic pharyngitis for the treatment of YIN-deficiency type the Radix Ophiopogonis of nourishing YIN and moistening the lung, can obviously alleviate pharyngitis symptom, improve overall deficiency of YIN state.
3, Radix Scrophulariae: property sweetness and bitterness is salty-cold, has clearing away heat and nourishing YIN, effect of detoxicating and resolving stagnation of pathogens, as a heat and toxic materials clearing away medicine treatment laryngopharynx swelling and pain, may be used for the laryngopharynx swelling and pain that pyretic toxicity causes, the deficiency of YIN of the vital organs of the human body is had to the effect of YIN nourishing simultaneously, asthenic fire falls in outstanding being apt to, and cures mainly the deficiency of YIN and gets angry, laryngopharynx swelling and pain.Radix Scrophulariae throat, be on the one hand its eliminating fire and detoxication by it, flourishing for fire-toxin, laryngopharynx swelling and pain can be used; It again can nourishing YIN to lower pathogenic fire in addition, for hyperactivity of fire caused by deficiency of YIN, upper bright throat and the dry pain of itching of throat occurred, it usually with compatibility Radix Ophiopogonis.Radix Scrophulariae is normal and Radix Rehmanniae compatibility also, and both can clearing away heat and cooling blood, can nourish kidney yin again, and it is quite effective in cure that the pharyngalgia caused hyperactivity of fire caused by deficiency of YIN, eyes are dry and astringent etc.
4, Flos Lonicerae: cold in nature, sweet in the mouth, energy eliminating fire and detoxication, lung moistening expelling phlegm for arresting cough, have the effect of coordinating the actions of various ingredients in a prescription and liyan jiedu, hygropyrexia resistance larynx, laryngopharynx swelling and pain etc. then had to the effect of removing toxic substances dysentery relieving, removing heat from blood sore-throat relieving, can treat the disease such as influenza, acute and chronic tonsillitis.Modern medicine study confirms that this medicine not only can heat-clearing and toxic substances removing, also has broad-spectrum antibacterial action, has inhibition in various degree to various bacteria and virus.Chronic pharyngitis, usually caused by bacteriological infection, therefore, can play good bacteriostasis with Flos Lonicerae, favourable to treatment pharyngitis.
5, Bulbus Fritillariae Cirrhosae: conventional Chinese medicine, bitter in the mouth, cold nature, primary efficacy and effect are resolving phlegm and relieving asthma, removing heat-phlegm, sugariness of holding concurrently again, therefore kind nourishing the lung to arrest cough, treatment lung has scorching cough expectorant few, the laryngopharyngeal diseases that deficiency of lung-YIN or the moon thanks to cause.Bulbus Fritillariae Cirrhosae is equal to use with Radix Ophiopogonis, the Radix Rehmanniae, can nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, be applicable to chronic cough lung-dryness syndrome due to deficiency of YIN person.
6, Radix Glycyrrhizae: sweet in the mouth, gas is put down, and property is delayed.There is heat-clearing and toxic substances removing, quench the thirst eliminate the phlegm, the effect such as coordinating the actions of various ingredients in a prescription.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and antiallergic action, can relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis.
7, arhat: cool in nature, sweet in the mouth, function lung heat clearing intestine moistening, cures mainly the disease such as pertussis, phlegm-fire cough; Be applicable to the pharyngitis of YIN-deficiency of the lung and kidney, have good curative effect for treatment acute tracheitis, acute tonsillitis, throat fire etc., there is promoting the production of body fluid to quench thirst, moisten the effect of throat and protection vocal cords.
Present invention also offers the application of described Chinese medicine composition in the medicine of preparation treatment acute and chronic pharyngitis, described medicine can be, according to market demand, described moistening and cleaning throat health-care Chinese medicinal composition is prepared into the dosage forms such as buccal tablet, capsule or oral liquid.
Present invention also offers the preparation method of described moistening and cleaning throat health-care Chinese medicinal composition, described moistening and cleaning throat health-care Chinese medicinal composition can according to the needs of market and user, and be prepared into the dosage forms such as buccal tablet, capsule or oral liquid, preparation method is as follows:
(1) Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae, Flos Lonicerae, Bulbus Fritillariae Cirrhosae, Radix Glycyrrhizae, Fructus Momordicae is taken by described weight, decoct with water 1-3 time, each 0.5-2 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.25-1.30 (50 DEG C);
(2) prepare buccal tablet: get step (1) described clear paste, with sucrose, dextrin, makes granule, dry, is pressed into buccal tablet;
(3) capsule is prepared: get step (1) described clear paste, add Pulvis Talci, magnesium oxide, dry, pulverize, sieve, incapsulate;
(4) prepare oral liquid: get step (1) described clear paste, add Mel, benzoic acid, sodium benzoate and water, stir, filter, make oral liquid.
Described Chinese medicine composition employs the material of the medicine-food two-purpose with effects such as heat-clearing and toxic substances removing, nourishing YIN and clearing away fire, promoting the production of body fluid to quench thirst, lung moistening expelling phlegm for arresting cough, cooperatively interact, can be used for the diseases such as treatment acute and chronic pharyngitis, be particularly useful for the dry mouth and tougue because pyretic toxicity causes, laryngopharynx swelling and pain, and the deficiency of YIN fiery, the prosperous asthenic fire folder chronic laryngitis person of the reality.
Detailed description of the invention
Below with reference to specific embodiment, the invention will be further described, for the technological parameter do not indicated especially or condition, can refer to routine techniques and carry out.
Embodiment 1 one kinds of moistening and cleaning throat health-care Chinese medicinal compositions (buccal tablet)
A kind of moistening and cleaning throat health-care Chinese medicinal composition, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 30 parts, Radix Ophiopogonis 30 parts, Radix Scrophulariae 30 parts, Flos Lonicerae 20 parts, Bulbus Fritillariae Cirrhosae 20 parts, 15 parts, Radix Glycyrrhizae, Fructus Momordicae 15 parts.
The preparation method of this moistening and cleaning throat health-care Chinese medicinal composition is as follows:
(1) take above-mentioned raw material, decoct with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.25-1.30 (50 DEG C);
(2) with sucrose, dextrin, makes granule, dry, is pressed into buccal tablet.
Embodiment 2 one kinds of moistening and cleaning throat health-care Chinese medicinal compositions (oral liquid)
A kind of moistening and cleaning throat health-care Chinese medicinal composition, the effective ingredient of described Chinese medicine composition is identical with embodiment 1.
The preparation method of this moistening and cleaning throat health-care Chinese medicinal composition is as follows:
(1) identical with step (1) method of embodiment 1;
(2) add Mel, benzoic acid, sodium benzoate and water, stir, filter, make oral liquid.
Embodiment 3 one kinds of moistening and cleaning throat health-care Chinese medicinal compositions (capsule)
A kind of moistening and cleaning throat health-care Chinese medicinal composition, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 20 parts, Radix Ophiopogonis 20 parts, Radix Scrophulariae 20 parts, Flos Lonicerae 10 parts, Bulbus Fritillariae Cirrhosae 15 parts, 10 parts, Radix Glycyrrhizae, Fructus Momordicae 10 parts.
The preparation method of this moistening and cleaning throat health-care Chinese medicinal composition is as follows:
(1) identical with step (1) method of embodiment 1;
(2) add Pulvis Talci, magnesium oxide, dry, pulverize, sieve, incapsulate.
Embodiment 4 Chinese medicine composition of the present invention is to the therapeutic effect of pharyngitis
Experimental subject: 60 routine patients, symptom with pharyngeal discomfort itch or pain or drying for primary symptom, the visible pharyngeal congestion of pharyngeal inspection be kermesinus, and that touches has obvious pain, swallows rear wall follicle hypertrophy.
Experimental technique: 60 routine patients are divided into three groups at random, often organize 20 examples, experimental group 1 takes buccal tablet prepared by the embodiment of the present invention 1, once takes 1; Experimental group 2 takes oral liquid prepared by the embodiment of the present invention 2, once takes 10 ~ 20ml; Experimental group 3 takes capsule prepared by the embodiment of the present invention 3, once takes one.Three groups are and take 3-6 time every day, within 5 days, are a course for the treatment of.
Experimental standard: 1. fully recover: pharyngalgia disappears, the transference cures such as dry mouth and tougue; 2. effective: the symptoms such as pharyngalgia disappears substantially, dry mouth and tougue be improved significantly; 3. effective: the symptoms such as pharyngalgia alleviates, dry mouth and tougue improve; 4. invalid: the symptoms such as pharyngalgia does not alleviate, dry mouth and tougue do not improve
Treatment test effect is in table 1, and result shows: after patient takes a course for the treatment of of Chinese medicine composition of the present invention, pharyngalgia disappears substantially, the symptoms such as dry mouth and tougue be improved significantly, the traditional Chinese medicine composition for treating effect wherein prepared by the proportioning of embodiment 1 is better.We find in addition, for some because heat, drink water very few, tcm diagnosis red tongue, no fur, thready pulse and counting, card belongs to hyperactivity of fire caused by deficiency of YIN, and asthenic fire upper punch person, after taking above-mentioned Chinese medicine composition, while pharyngalgia symptom is eased, the symptom such as insomnia and dreamful sleep, vexed hectic fever also be improved significantly.
The therapeutic effect test of table 1 pharyngitis
| Recovery from illness | Effective | Effectively | Invalid | Total effective rate | |
| Experimental group 1 | 3 | 12 | 3 | 2 | 90％ |
| Experimental group 2 | 2 | 11 | 4 | 3 | 85％ |
| Experimental group 3 | 1 | 9 | 5 | 5 | 75％ |
Each technical characteristic of the above embodiment can combine arbitrarily, for making description succinct, the all possible combination of each technical characteristic in above-described embodiment is not all described, but, as long as the combination of these technical characteristics does not exist contradiction, be all considered to be the scope that this description is recorded.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be construed as limiting the scope of the patent.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (7)
1. a moistening and cleaning throat health-care Chinese medicinal composition, it is characterized in that, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 20-40 part, Radix Ophiopogonis 20-40 part, Radix Scrophulariae 20-40 part, Flos Lonicerae 10-30 part, Bulbus Fritillariae Cirrhosae 10-30 part, Radix Glycyrrhizae 10-20 part, Fructus Momordicae 10-20 part.
2. moistening and cleaning throat health-care Chinese medicinal composition according to claim 1, it is characterized in that, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 25-35 part, Radix Ophiopogonis 25-35 part, Radix Scrophulariae 25-35 part, Flos Lonicerae 15-25 part, Bulbus Fritillariae Cirrhosae 15-25 part, Radix Glycyrrhizae 13-17 part, Fructus Momordicae 13-17 part.
3. moistening and cleaning throat health-care Chinese medicinal composition according to claim 2, it is characterized in that, the effective ingredient of described Chinese medicine composition is prepared from by following raw material: Radix Rehmanniae 30 parts, Radix Ophiopogonis 30 parts, Radix Scrophulariae 30 parts, Flos Lonicerae 20 parts, Bulbus Fritillariae Cirrhosae 20 parts, 15 parts, Radix Glycyrrhizae, Fructus Momordicae 15 parts.
4. the moistening and cleaning throat health-care Chinese medicinal composition according to any one of claim 1-3, is characterized in that, the dosage form of described Chinese medicine composition is tablet, capsule, oral liquid, granule, mixture, pill, drop pill, slow releasing tablet, microcapsule, micropill.
5. moistening and cleaning throat health-care Chinese medicinal composition according to claim 4, is characterized in that, the dosage form of described Chinese medicine composition is buccal tablet, capsule or oral liquid.
6. the preparation method of the moistening and cleaning throat health-care Chinese medicinal composition described in an any one of claim 1-5, it is characterized in that, comprise the following steps: take Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae, Flos Lonicerae, Bulbus Fritillariae Cirrhosae, Radix Glycyrrhizae, Fructus Momordicae, decoct with water 1-3 time, each 0.5-2 hour, collecting decoction, filters, relative density when filtrate is concentrated into 50 DEG C is the clear paste of 1.25-1.30, obtains described moistening and cleaning throat health-care Chinese medicinal composition.
7. the application of the Chinese medicine composition described in an any one of claim 1-5 in the medicine of preparation treatment acute and chronic pharyngitis.
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| CN113940944A (en) * | 2021-12-07 | 2022-01-18 | 东阳市人民医院 | A Chinese medicinal composition for treating chronic pharyngitis |
| CN116077601A (en) * | 2023-04-07 | 2023-05-09 | 江西草珊瑚药业有限公司 | Lozenge for clearing heat, relieving cough and reducing sputum and preparation method thereof |
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| CN108077514A (en) * | 2018-01-24 | 2018-05-29 | 重庆创生生物科技集团有限公司 | A kind of radix scrophulariae clearing health-care cold tea and preparation method thereof |
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| CN113940944B (en) * | 2021-12-07 | 2023-10-17 | 东阳市人民医院 | A Chinese medicinal preparation for treating chronic pharyngitis |
| CN116077601A (en) * | 2023-04-07 | 2023-05-09 | 江西草珊瑚药业有限公司 | Lozenge for clearing heat, relieving cough and reducing sputum and preparation method thereof |
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