CN104815152A - Throat-moistening and cough-relieving candy, preparation method and application thereof - Google Patents
Throat-moistening and cough-relieving candy, preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a throat-moistening and cough-relieving candy, a preparation method and an application thereof. The throat-moistening and cough-relieving candy comprises following traditional Chinese raw medicines, by weight, 9-21 parts of lily, 1-5 parts of rhododendron mariae, 1-5 parts of trollius chinensis, 9-21 parts of honeysuckles, 4-14 parts of dark plums, 9-21 parts of platycodon grandiflorum and 6-18 parts of pericarpium citri reticulatae. The candy is used for treating laryngeal cough and bronchitis, and is high in curative rate and effective rate.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of throat lozenge and its preparation method and application.
Background technology
The property cough of pharynx source is the chronic stimulation dry cough that chronic pharyngitis causes, and chronic pharyngitis is adenoid diffuse inflammation under pharynx mucosa, mucosa, and belonging to common multiple disease, is the disease that the time in spring and autumn is sent out well.Symptom is simple, but many delays with the passing of time, and touching difficulty more.Namely pharynx source property cough clinical manifestation is coughed as principal character with itching throat, and often bring out because tobacco and wine, pungent, cold and heat etc. stimulate or increase the weight of, disease sees itching throat, foreign body in pharynx sense, and dry cough without phlegm or expectorant glue difficulty and coughs up, the weary effect of medical treatment.The course of disease reaches even several months several weeks, and pulmonary checks without obvious positive sign, and the visible pharyngeal mucous membrane chronic congestion of pharyngeal inspection, drying, retropharyneal folliculosis, severe patient pharynx rear wall mucosal atrophy.Because this type of cough is relevant with pharyngeal Acute and chronic inflammation, therefore be referred to as the property cough of pharynx source, its application antibiotic, calmness and cough suppressing medicine therapeutic effect are often unsatisfied with.
Bronchitis refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Bronchitis main cause is that the repeated infection of virus and antibacterial defines bronchial chronic nonspecific inflammation.When under mercury dropped, respiratory tract small blood vessel spasm ischemia, defense function, degradation is beneficial to pathogenic, the chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill, smoking makes the variation of bronchospasm, mucosa, ciliary movement reduces, mucilage secretion increases advantageous infectivity, and intolerance factors also has certain relation.Clinical symptoms is cough, and expectoration companion pant, Relapse rate, and the course of disease is delayed.Apply the antibiotic such as erythromycin clinically, eliminate the phlegm and cough-relieving, suppressing panting calming medicine treatment, Relapse rate, effect is undesirable.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of throat lozenge and preparation method thereof.
Another object of the present invention is to provide the application of a kind of throat lozenge in the property cough of preparation treatment pharynx source, bronchitis medicine.
A kind of throat lozenge, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 9-21 part, Folium et Cacumen Rhododendri Mariae 1-5 part, Flos Trollii 1-5 part, Flos Lonicerae 9-21 part, Fructus Mume 4-14 part, Radix Platycodonis 9-21 part, Pericarpium Citri Reticulatae 6-18 part.
Preferably, above-mentioned throat lozenge, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 12-18 part, Folium et Cacumen Rhododendri Mariae 2-4 part, Flos Trollii 2-4 part, Flos Lonicerae 12-18 part, Fructus Mume 6-12 part, Radix Platycodonis 12-18 part, Pericarpium Citri Reticulatae 9-15 part.
Preferred, above-mentioned throat lozenge, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 15 parts, Folium et Cacumen Rhododendri Mariae 3 parts, Flos Trollii 3 parts, Flos Lonicerae 15 parts, Fructus Mume 9 parts, Radix Platycodonis 15 parts, Pericarpium Citri Reticulatae 12 parts.
Preferred, above-mentioned throat lozenge, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 12 parts, Folium et Cacumen Rhododendri Mariae 2 parts, Flos Trollii 2 parts, Flos Lonicerae 12 parts, Fructus Mume 6 parts, Radix Platycodonis 12 parts, Pericarpium Citri Reticulatae 9 parts.
Preferred, above-mentioned throat lozenge, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 18 parts, Folium et Cacumen Rhododendri Mariae 4 parts, Flos Trollii 4 parts, Flos Lonicerae 18 parts, Fructus Mume 12 parts, Radix Platycodonis 18 parts, Pericarpium Citri Reticulatae 15 parts.
The preparation method of above-mentioned throat lozenge, comprises the steps:
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each decoction 1.5 hours, merge decoction liquor, 70 DEG C are concentrated into relative density is 1.18-1.22, and drying obtains extract powder;
(2) in clean container, pour 1000 parts of Mel or Sugarless type excipient into, 200 parts of extract powders are added in load weighted 1000 parts of Mel or Sugarless type excipient, stirs, add 150 parts of water again, stir, finally add 1200 portions of white sugars or Sugarless type excipient, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add essence, after stirring, pour mould into, molding, cooling, to obtain final product; Or after stirring, cooling, extruded, to obtain final product.
Preferably, in the preparation method of above-mentioned throat lozenge, the method for described drying can be vacuum drying, spraying dry or microwave drying.
The preparation method of above-mentioned throat lozenge, also can comprise the steps:
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each to decoct 1.5 hours, merge decoction liquor, 70 DEG C concentrated obtains the extraction cream that relative density is 1.18-1.22;
(2) in clean container, pour 1000 parts of Mel or Sugarless type excipient into, extract cream by 200 parts and add in load weighted 1000 parts of Mel or Sugarless type excipient, stir, add 150 parts of water again, stir, finally add 1200 portions of white sugars or Sugarless type excipient, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add essence, after stirring, pour mould into, molding, cooling, to obtain final product; Or after stirring, cooling, extruded, to obtain final product.
The odor type of described essence can be Citrullus vulgaris odor type, freshener odor type, citrus seed oil odor type, lemon flavor, Herba Pileae Scriptae odor type, Mel odor type, draft odor type, Semen Armeniacae Amarum Fruity type, sweet taste odor type etc., but is not limited to the above-mentioned essence odor type enumerated.
Described Sugarless type excipient can be one or more of maltose alcohol, lactose, xylitol or hydroxyl isomaltulose.
The application of above-mentioned throat lozenge in preparation treatment pharynx source property cough medicine.
The application of above-mentioned throat lozenge in preparation treatment bronchitis medicine.
Throat lozenge of the present invention has and relieves inflammation or internal heat, and lung moistening, wets one's whistle, and awake stomach is regulated the flow of vital energy, and astringes the lung, effect of yin nourishing, can be used for bronchitis, chronic pharyngitis and the cough of pharynx source property.
In the prescription of throat lozenge of the present invention, Bulbus Lilii female relieving cough and moistening lung, YIN nourishing sore-throat relieving, Folium et Cacumen Rhododendri Mariae, gold silver the flowers are in blossom lung qi dispersing gas and loose exopathogen, Flos Trollii cleaning throat and moistening larynx, many sick the mistakes for a long time of pharynx source property cough control wrong treatment, and consumption impairment of QI is cloudy, Fructus Mume is astringed the lung and is promoted the production of body fluid, the Pericarpium Citri Reticulatae dispelling wind that reduces phlegm is antipruritic, and Radix Platycodonis is for making medicine, and medicine carrying heads direct for throat and sore-throat relieving.The property cough of we's treatment pharynx source, bronchitis, effect is concentrated one's efforts grand, good recipe of can yet be regarded as.
Throat lozenge of the present invention is adopted to treat 88 routine pharynx source property cough patients, in 88 routine patients, recovery from illness 59 example, effective 26 examples, invalid 3 examples, cure rate 66.29%, total effective rate 96.59%; Treat 140 routine bronochitics, recovery from illness 114 example, effective 17 examples, no effect 9, cure rate 81.43%, total effective rate 93.57%.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1 one kinds of sugar-containing type throat lozenge
Prescription: Bulbus Lilii 150g, Folium et Cacumen Rhododendri Mariae 30g, Flos Trollii 30g, Flos Lonicerae 150g, Fructus Mume 90g, Radix Platycodonis 150g, Pericarpium Citri Reticulatae 120g.
Preparation method:
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each decoction 1.5 hours, merge decoction liquor, 70 DEG C are concentrated into relative density is 1.18-1.22, and spraying dry obtains extract powder;
(2) in clean container, pour 10000g Mel into, 2000g extract powder is added in load weighted 10000g Mel, stirs, add 1500g water again, stir, finally add 12000g white sugar, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add lemon flavor essence, after stirring, pour mould into, molding, cooling, to obtain final product.Prepare throat lozenge 1000 altogether.
Embodiment 2 one kinds of Sugarless type throat lozenge
Bulbus Lilii 120g, Folium et Cacumen Rhododendri Mariae 20g, Flos Trollii 20g, Flos Lonicerae 120g, Fructus Mume 60g, Radix Platycodonis 120g, Pericarpium Citri Reticulatae 90g.
Preparation method:
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each decoction 1.5 hours, merge decoction liquor, 70 DEG C are concentrated into relative density is 1.18-1.22, and vacuum drying obtains extract powder;
(2) in clean container, pour 10000g xylitol into, 2000g extract powder is added in load weighted 10000g xylitol, stirs, add 1500g water again, stir, finally add 12000g lactose, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add Herba Pileae Scriptae flavor essence, after stirring, pour mould into, molding, cooling, to obtain final product.Prepare throat lozenge 1000 altogether.
Embodiment 3 one kinds of sugar-containing type throat lozenge
Bulbus Lilii 180g, Folium et Cacumen Rhododendri Mariae 40g, Flos Trollii 40g, Flos Lonicerae 180g, Fructus Mume 120g, Radix Platycodonis 180g, Pericarpium Citri Reticulatae 150g.
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each to decoct 1.5 hours, merge decoction liquor, 70 DEG C concentrated obtains the extraction cream that relative density is 1.18-1.22;
(2) in clean container, pour 1000 parts of Mel into, extract cream by 200 parts and add in load weighted 1000 parts of Mel, stir, add 150 parts of water again, stir, finally add 1200 portions of white sugars, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add draft flavor essence, after stirring, pour mould into, molding, cooling, to obtain final product; Or after stirring, cooling, extruded, to obtain final product.
Embodiment 4 one kinds of sugar-containing type throat lozenge
Bulbus Lilii 180g, Folium et Cacumen Rhododendri Mariae 40g, Flos Trollii 40g, Flos Lonicerae 180g, Fructus Mume 120g, Radix Platycodonis 180g, Pericarpium Citri Reticulatae 150g.
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each to decoct 1.5 hours, merge decoction liquor, 70 DEG C concentrated obtains the extraction cream that relative density is 1.18-1.22;
(2) in clean container, pour 1000 parts of maltose alcohol excipient into, extract cream by 200 parts and add in load weighted 1000 parts of maltose alcohol excipient, stir, add 150 parts of water again, stir, finally add 1200 parts of maltose alcohol excipient, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add Semen Armeniacae Amarum Fruity type essence, after stirring, pour mould into, molding, cooling, to obtain final product; Or after stirring, cooling, extruded, to obtain final product.
Embodiment 5
Bulbus Lilii 90g, Folium et Cacumen Rhododendri Mariae 10g, Flos Trollii 10g, Flos Lonicerae 90g, Fructus Mume 40g, Radix Platycodonis 90g, Pericarpium Citri Reticulatae 60g.
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each decoction 1.5 hours, merge decoction liquor, 70 DEG C are concentrated into relative density is 1.18-1.22, and spraying dry obtains extract powder;
(2) in clean container, pour 10000g Mel into, 2000g extract powder is added in load weighted 10000g Mel, stirs, add 1500g water again, stir, finally add 12000g white sugar, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add freshener flavor essence, after stirring, pour mould into, molding, cooling, to obtain final product.Prepare throat lozenge 1000 altogether.
Embodiment 6
Bulbus Lilii 210g, Folium et Cacumen Rhododendri Mariae 50g, Flos Trollii 50g, Flos Lonicerae 210g, Fructus Mume 140g, Radix Platycodonis 210g, Pericarpium Citri Reticulatae 180g.
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each decoction 1.5 hours, merge decoction liquor, 70 DEG C are concentrated into relative density is 1.18-1.22, and spraying dry obtains extract powder;
(2) in clean container, pour 10000g lactose into, 2000g extract powder is added in load weighted 10000g lactose, stirs, add 1500g water again, stir, finally add 12000g hydroxyl isomaltulose, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add Citrullus vulgaris flavor essence, after stirring, pour mould into, molding, cooling, to obtain final product.Prepare throat lozenge 1000 altogether.
Test effect of throat lozenge prepared by the embodiment of the present invention 1, Details as Follows:
One, the property cough of pharynx source is used for the treatment of
1, physical data
88 routine patients, the oldest 72 years old, minimum 15 years old; Wherein man 43 example, female 45 example; The course of disease is the longest 1.5 years, the shortest 3d, and its main manifestations is dry cough, and namely itching throat is coughed, and pharyngalgia is uncomfortable, and xerostomia is bitter, happiness drinking-water, and stool or knot, yellow urine, body of the tongue is partially red, yellow and thin fur, floating and rapid pulse.
2, Therapeutic Method
Give throat lozenge of the present invention, each 2, every 2 hours 1 time, 5 ~ 6 times on the one.Treatments period does not all give other drug.The pungent stimulation food of fasting and tobacco and wine, and note preventing cold.
3, criterion of therapeutical effect
Recovery from illness: itching throat cough disappears; Effective: cough obviously alleviates; Invalid: cough is without obviously alleviating.
4, therapeutic outcome
In 88 routine patients, recovery from illness 59 example, effective 26 examples, invalid 3 examples, cure rate 66.29%, total effective rate 96.59%.
Two, bronchitis is used for the treatment of
1, physical data
140 routine patients, the oldest 78 years old, minimum 15 years old; Wherein man 75 example, female 65 example; The course of disease was more than 2 years, and annual morbidity three months, its main manifestations is cough, and expectoration companion pant, and two increased bronchovascular shadows, disorder, in netted or mottling.
2, Therapeutic Method
Give throat lozenge of the present invention, each 1, every 0.5 hour 1 time, 6 ~ 8 times on the one.Treatments period does not all give other drug.The pungent stimulation food of fasting and tobacco and wine, and note preventing cold.
3, criterion of therapeutical effect
Recovery from illness: cough with asthma disappears, and x-ray checks two lung marking no abnormality seens; Effective: cough with asthma obviously alleviates, x-ray checks that netted or mottling improves; Invalid: cough with asthma is without obviously alleviating, and x-ray checks without improving.
4, therapeutic outcome
In 140 routine patients, recovery from illness 114 example, effective 17 examples, no effect 9, cure rate 81.43%, total effective rate 93.57%.
Claims (10)
1. a throat lozenge, is characterized in that, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 9-21 part, Folium et Cacumen Rhododendri Mariae 1-5 part, Flos Trollii 1-5 part, Flos Lonicerae 9-21 part, Fructus Mume 4-14 part, Radix Platycodonis 9-21 part, Pericarpium Citri Reticulatae 6-18 part.
2. throat lozenge according to claim 1, is characterized in that, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 12-18 part, Folium et Cacumen Rhododendri Mariae 2-4 part, Flos Trollii 2-4 part, Flos Lonicerae 12-18 part, Fructus Mume 6-12 part, Radix Platycodonis 12-18 part, Pericarpium Citri Reticulatae 9-15 part.
3. throat lozenge according to claim 2, is characterized in that, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 15 parts, Folium et Cacumen Rhododendri Mariae 3 parts, Flos Trollii 3 parts, Flos Lonicerae 15 parts, Fructus Mume 9 parts, Radix Platycodonis 15 parts, Pericarpium Citri Reticulatae 12 parts.
4. throat lozenge according to claim 2, is characterized in that, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 12 parts, Folium et Cacumen Rhododendri Mariae 2 parts, Flos Trollii 2 parts, Flos Lonicerae 12 parts, Fructus Mume 6 parts, Radix Platycodonis 12 parts, Pericarpium Citri Reticulatae 9 parts.
5. throat lozenge according to claim 2, is characterized in that, the raw material packet of described throat lozenge contains the raw material of Chinese medicine medicine of following parts by weight:
Bulbus Lilii 18 parts, Folium et Cacumen Rhododendri Mariae 4 parts, Flos Trollii 4 parts, Flos Lonicerae 18 parts, Fructus Mume 12 parts, Radix Platycodonis 18 parts, Pericarpium Citri Reticulatae 15 parts.
6. the preparation method of the throat lozenge according to claim 1 or 2 or 3, is characterized in that, comprise the steps:
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each decoction 1.5 hours, merge decoction liquor, 70 DEG C are concentrated into relative density is 1.18-1.22, and drying obtains extract powder;
(2) in clean container, pour 1000 parts of Mel or lactose into, 200 parts of extract powders are added in load weighted 1000 parts of Mel or lactose, stirs, add 150 parts of water again, stir, finally add 1200 portions of white sugars or xylitol, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add essence, after stirring, pour mould into, molding, cooling, to obtain final product; Or after stirring, cooling, extruded, to obtain final product.
7. the preparation method of throat lozenge according to claim 6, is characterized in that, the method for described drying can be vacuum drying, spraying dry or microwave drying.
8. the preparation method of the throat lozenge according to claim 1 or 2 or 3, is characterized in that, comprise the steps:
(1) proportionally take raw material of Chinese medicine medicine, decoct with water 2 times, each to decoct 1.5 hours, merge decoction liquor, 70 DEG C concentrated obtains the extraction cream that relative density is 1.18-1.22;
(2) in clean container, pour 1000 parts of Mel or Sugarless type excipient into, extract cream by 200 parts and add in load weighted 1000 parts of Mel or Sugarless type excipient, stir, add 150 parts of water again, stir, finally add 1200 portions of white sugars or Sugarless type excipient, heat while stirring, when temperature rises to 140 DEG C-170 DEG C, add essence, after stirring, pour mould into, molding, cooling, to obtain final product; Or after stirring, cooling, extruded, to obtain final product.
9. claim 1 or the application of the throat lozenge described in 2 or 3 in preparation treatment pharynx source property cough medicine.
10. claim 1 or the application of the throat lozenge described in 2 or 3 in preparation treatment bronchitis medicine.
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Application publication date: 20150805 |