CN107929393A - Chitosan oligosaccharide wets one's whistle oral cavity tabletting and preparation method thereof - Google Patents
Chitosan oligosaccharide wets one's whistle oral cavity tabletting and preparation method thereof Download PDFInfo
- Publication number
- CN107929393A CN107929393A CN201711448499.2A CN201711448499A CN107929393A CN 107929393 A CN107929393 A CN 107929393A CN 201711448499 A CN201711448499 A CN 201711448499A CN 107929393 A CN107929393 A CN 107929393A
- Authority
- CN
- China
- Prior art keywords
- milligrams
- chitosan oligosaccharide
- tabletting
- whistle
- oral cavity
- Prior art date
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- Pending
Links
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 title claims abstract description 28
- 210000000214 mouth Anatomy 0.000 title claims abstract description 14
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 8
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 7
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- JCZPMGDSEAFWDY-SQOUGZDYSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanamide Chemical compound NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO JCZPMGDSEAFWDY-SQOUGZDYSA-N 0.000 description 1
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
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- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
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- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical group Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
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- LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Wet one's whistle oral cavity tabletting and preparation method thereof the present invention relates to a kind of chitosan oligosaccharide, include each component of following parts by weight, 100 300 milligrams of chitosan oligosaccharide, 80 120 milligrams of fructose, 30 100 milligrams of Fructus Canarii extract, 30 80 milligrams of smoked plum extractive, 30 80 milligrams of Hang Ju extracts, 5 15 milligrams of maltodextrin, 5 15 milligrams of microcrystalline cellulose, 5 15 milligrams of hydroxypropyl methyl cellulose, 5 15 milligrams of sodium carboxymethylcellulose, 40 60 milligrams of lecithin.Advantages of the present invention：The demand of the market health of chronic pharyngitis and canker sore is solved, effect is obvious, with strong points, and easy to preserve, preparation method is simple and practicable.
Description
Technical field
Wet one's whistle oral cavity tabletting and preparation method thereof the present invention relates to a kind of chitosan oligosaccharide, belong to health-care sweets fruit technology neck
Domain.
Background technology
Chronic pharyngitis is most common disease in pharyngolaryngitis, and clinic is common to be：Abscess of throat, pharyngeal discomfort, foreign body sensation,
The symptoms such as cough, pharyngeal secretion are not easy to bring up, nausea and vomiting, pharyngeal dry gargalesthesia, burn feeling, dry sensation or excitement.Its disease
Change is related to pharyngeal neighbouring upper respiratory tract lesion, temperature, the change of humidity, air quality are poor, tobacco and wine stimulate, pungent irritation is eaten
Thing, dust etc., allergy and other factors.The incidence of the various mouth diseases in China is up to 97.6%, wherein 20% is canker sore,
Canker sore is mostly recurrent, since ulcer gives people burn feeling and the feeling of pain brought, makes us really worried.China is chronic
Pharyngitis incidence is up to 50%, and wherein Urban Areas will be far above rural area.
There are Caoshan Hu Hanpian, water melon frost, slow tight Shu Ning, the vertical refreshing, Hua Su of pharynx on the market for chronic pharyngitis and canker sore
Piece, Bingpeng San, meaning can paste etc. and the thoat-soothing drops of the various Chinese medicines containing antipyretic and antidotal type.Although this kind of medicine, candy can alleviate pharynx
The symptom of pain and canker sore.But the materials such as glucose, sucrose are with the addition of in terms of main additive, for glycemic control and body
Body is unfavorable.
The content of the invention
The defects of to overcome the prior art, the present invention provide a kind of chitosan oligosaccharide and wet one's whistle oral cavity tabletting and preparation method thereof, this
The technical solution of invention is：
Chitosan oligosaccharide wets one's whistle oral cavity tabletting, includes each component of following parts by weight, 100-300 milligrams of chitosan oligosaccharide, fructose 80-120 millis
Gram, 30-100 milligrams of Fructus Canarii extract, 30-80 milligrams of smoked plum extractive, 30-80 milligrams of Hang Ju extracts, maltodextrin 5-15
Milligram, 5-15 milligrams of microcrystalline cellulose, 5-15 milligrams of hydroxypropyl methyl cellulose, 5-15 milligrams of sodium carboxymethylcellulose, lecithin
40-60 milligrams of fat.
200 milligrams of the chitosan oligosaccharide, 100 milligrams of fructose, 50 milligrams of Fructus Canarii extract, 50 milligrams of smoked plum extractive, Hangzhoupro
50 milligrams of chrysanthemum extract, 10 milligrams of maltodextrin, 10 milligrams of microcrystalline cellulose, 10 milligrams of hydroxypropyl methyl cellulose, carboxymethyl
10 milligrams of sodium cellulosate, 50 milligrams of lecithin.
A kind of chitosan oligosaccharide for preparing wets one's whistle the preparation method of oral cavity tabletting, comprises the following steps：
（1）Each parts by weight are weighed according to proportioning；
（2）All components are uniformly mixed；
（3）It is put into tabletting in tablet press machine；
（4）Tabletting is dried on drying machine；
（5）Disinfection；
（6）It is packaged into box.
It is an advantage of the invention that：
Chitosan oligosaccharide：Chitosan oligosaccharide is that a kind of degree of polymerization that chitosan is degraded through biological enzyme technology oligosaccharides between 2 ~ 20 produces
Product, molecular weight≤3200Da, is water-soluble low molecular weight product preferable, function is big, bioactivity is high, has molecular weight
The advantage such as low, good water solubility, function is big, be easily absorbed by the body, bioactivity height；Human body negative oxygen ion can substantially be eliminated certainly
By base, body cell is activated, is slowed down aging, suppresses skin surface harmful bacteria and grows；It is immune with improving, suppress the life of cancerous swelling cell
It is long, promote liver and spleen antibody to be formed, promote the human body profitable strain such as the absorption of calcium and mineral matter, propagation Bifidobacterium, lactic acid bacteria, drop
The functions such as blood fat, blood pressure lowering, hypoglycemic, adjusting cholesterol, weight-reducing, prevention adult disease.
Fructose：One kind is refined from various fruit and cereal, the new carbohydrate all natural, sweet taste is strong, and fructose is monose, molecule
Small compared with sucrose, osmotic pressure is higher by one times than sucrose, can penetration cell tissue quickly, be conducive to suppress the life of food surface microorganism
It is long, have the advantages that in good taste, sugariness is high, glycemic index is low and do not easily lead to carious tooth.The sugariness of fructose is the 1.8 of sucrose
Times, it is the highest sugar of sugariness in all natural sugars, antiseptic property is good.
Fructus Canarii extract：This product is the fruit extract of rosaceae plant deciduous tree plum, and the excited salivary gland of this product energy, is
Salivary secretion increase, therefore contribute to digestion.Function is clearing heat and detoxicating, secretion replenishing and throat moistening, preventing phlegm from forming and stopping coughing.Attacked in wind-heat or hot
Poison pents up and causes abscess of throat etc.；Can be with dry throat to be controlled, polydipsia is silent, cough with ropy sputum.
Smoked plum extractive：Numerous organic acids such as smoked plum extractive edge containing Chinese holly acid, malic acid, oxalic acid.Pharmacological action is anti-inflammatory
Parasite elimination, relieving spasm and pain, relieving restlessness heat-clearing effect, controls neurasthenia, controls the diabetes glucose effect of not dropping etc..Histocyte can be strengthened
Function, improves phagocytic function, has inhibitory action to cancer cell.
Hang Ju extracts：Glucoside containing chrysanthemum, amino acid, flavonoids and multivitamin and trace element, there is antibacterial, antipyretic work
With.Chinese medical research shows, Hang Ju extracts, which have, to nourish the liver to improve visual acuity, clears away heart-fire, kidney tonifying, strengthening the spleen and stomach, wets one's whistle, promote the production of body fluid, and
Adjust blood fat and other effects.Often drink this product, the spring warm up dry, summer heat quenches one's thirst, solution dry, winter on autumn days relieves inflammation or internal heat.More can beautifying face and moistering lotion, enrich blood
Refresh oneself, to strengthen the vigor of life, make one to slow down aging, can more the elderly is promoted longevity.
The basic matterial shell with obvious antibacterial action is added on the basis of original clearing heat and detoxicating, enriching yin clearing away the heart-fire Chinese medicine
Oligosaccharides, addition sugariness is low on adjustment taste, to fructose of the blood glucose without influence.Fructose is as general in a kind of most fruits
All over existing component, eaten for a long time by people.The 70's of 20th century fructose production technology bottleneck is broken through, by business
Productization are applied among many food such as beverage, bakery product, preserved fruit, until 20th century latter stage fructose because its sugariness is high,
Mouthfeel alcohol, metabolic pathway are different from sucrose, and are considered as always a kind of carbohydrate with healthcare function that may replace sucrose, and
Recommend the table sugar as diabetic.According to the literature, nearly 2 000 ten thousand tons of global shrimp and crab shells annual output, shellfish, shell class
Produce 1390000 tons of chitin per year, the hyphomycetes in fermentation by-product produces 90000 tons of chitin per year.The Department of Science and Technology is by " chitosan oligosaccharide new product
Development and application " be classified as national " 15 " Program for Tackling Key Problems, it is desirable to establish several chitosan oligosaccharide production lines for producing more than 500 tons per year,
2015 gross annual output values are up to hundred million yuan of 1 100 hundred million~1 3OO, to meet the needs of domestic market.But chitosan oligomer
Prepare, especially the preparation of 6~8 chitosan oligosaccharide of the degree of polymerization is greatly all in the conceptual phase in laboratory.It is known as " the 6th life of human body
The chitin of key element ", the good reputation of " soft gold "（Chitin）It is widely present in marine product and hyphomycetes.But since its is insoluble
Yu Shui, is limited by very large in development and application.And chitosan oligosaccharide（Also known as oligomerization aminoglucose, chitin oligosaccharide）By crust
Matter（Chitin）Deacetylated product degradation of chitosan obtains, and is to pass through β -1-4 glycosidic bonds by 2~10 aminoglucoses
The oligosaccharide being formed by connecting, and unique a large amount of existing basic amine group polysaccharide in natural sugar, good water solubility, is easily inhaled by animal body
Receive.Chitosan oligosaccharide has the function that harmful bacteria in suppression alimentary canal, and chitosan oligosaccharide has the function of to promote bifidobacterium growth, improves intestines
Road tissue morphology, adjust intestinal microecology.Strengthen immune function.Buccal tablet is not only to chronic pharyngitis made of above material
With canker sore tool improve significantly, and in added material it is environmentally friendly, natural, easy to maintain, mouthfeel is good, to blood glucose and stomach
Gut function has no adverse effects, the early recovery for promoting oropharynx health.The purpose of the present invention is to solve chronic pharyngitis and
The demand of the market health of canker sore, effect is obvious, with strong points, and easy to preserve, preparation method is simple and practicable.
Embodiment
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.But these embodiments are only exemplary, do not form any restrictions to the scope of the present invention.People in the art
Member it should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and form into
Row modifications or substitutions, but these modifications and replacement are each fallen within protection scope of the present invention.
Embodiment 1：Wet one's whistle oral cavity tabletting the present invention relates to a kind of chitosan oligosaccharide, include each component of following parts by weight, shell is few
100 milligrams of sugar, 80 milligrams of fructose, 30 milligrams of Fructus Canarii extract, 30 milligrams of smoked plum extractive, 30 milligrams of Hang Ju extracts, malt
5 milligrams of dextrin, 5 milligrams of microcrystalline cellulose, 5 milligrams of hydroxypropyl methyl cellulose, 5 milligrams of sodium carboxymethylcellulose, lecithin 40
Milligram.
The chitosan oligosaccharide wets one's whistle the preparation method of oral cavity tabletting, comprises the following steps：
（1）Each parts by weight are weighed according to proportioning；
（2）All components are uniformly mixed；
（3）It is put into tabletting in tablet press machine；
（4）Tabletting is dried on drying machine；
（5）Disinfection；
（6）It is packaged into box.
Embodiment 2：Wet one's whistle oral cavity tabletting the present invention relates to a kind of chitosan oligosaccharide, include each component of following parts by weight, it is described
200 milligrams of chitosan oligosaccharide, 100 milligrams of fructose, 50 milligrams of Fructus Canarii extract, 50 milligrams of smoked plum extractive, the milli of Hang Ju extracts 50
Gram, 10 milligrams of maltodextrin, 10 milligrams of microcrystalline cellulose, 10 milligrams of hydroxypropyl methyl cellulose, the milli of sodium carboxymethylcellulose 10
Gram, 50 milligrams of lecithin, preparation method is the same as embodiment 1.
Embodiment 3：Wet one's whistle oral cavity tabletting the present invention relates to a kind of chitosan oligosaccharide, include each component of following parts by weight, shell is few
300 milligrams of sugar, 120 milligrams of fructose, 100 milligrams of Fructus Canarii extract, 80 milligrams of smoked plum extractive, 80 milligrams of Hang Ju extracts, wheat
15 milligrams of bud dextrin, 15 milligrams of microcrystalline cellulose, 15 milligrams of hydroxypropyl methyl cellulose, 15 milligrams of sodium carboxymethylcellulose, ovum
0 milligram of phosphatidase 6, preparation method is the same as embodiment 1.
Clinical case：Patient totally 200 is observed, daily lozenge 3 times, 1 tablet once, continuous 10 days.Diagnostic criteria is equal
Meet what bureau of drug administration of the Ministry of Public Health formulated for 2002《New drug (Chinese medicine) treats chronic pharyngitis guideline of clinical investigations》Diagnosis mark
It is accurate；Efficacy assessment standard is effective：Symptom disappears, and pharyngeal contrafluxion decline, having folliculus, person disappears substantially；Effectively：Clinical symptoms
Improve, pharyngeal mucosa is congested to be mitigated, and pharynx rear wall lymph follicle is reduced；It is invalid：Symptom, sign are without improvement after treatment.
As a result effective 112, effective 88, total effective rate 100%.
Claims (3)
- The oral cavity tabletting 1. chitosan oligosaccharide wets one's whistle, it is characterised in that include each component of following parts by weight, 100-300 milligrams of chitosan oligosaccharide, 80-120 milligrams of fructose, 30-100 milligrams of Fructus Canarii extract, 30-80 milligrams of smoked plum extractive, 30-80 milligrams of Hang Ju extracts, 5-15 milligrams of maltodextrin, 5-15 milligrams of microcrystalline cellulose, 5-15 milligrams of hydroxypropyl methyl cellulose, sodium carboxymethylcellulose 5- 15 milligrams, 40-60 milligrams of lecithin.
- The oral cavity tabletting 2. chitosan oligosaccharide according to claim 1 wets one's whistle, it is characterised in that 200 milligrams of the chitosan oligosaccharide, fruit 100 milligrams of sugar, 50 milligrams of Fructus Canarii extract, 50 milligrams of smoked plum extractive, 50 milligrams of Hang Ju extracts, 10 milligrams of maltodextrin, 10 milligrams of microcrystalline cellulose, 10 milligrams of hydroxypropyl methyl cellulose, 10 milligrams of sodium carboxymethylcellulose, 50 milligrams of lecithin.
- The preparation method of oral cavity tabletting 3. a kind of chitosan oligosaccharide prepared described in claim 1 or 2 wets one's whistle, it is characterised in that including Following steps：（1）Each parts by weight are weighed according to proportioning；（2）All components are uniformly mixed；（3）It is put into tabletting in tablet press machine；（4）Tabletting is dried on drying machine；（5）Disinfection；（6）It is packaged into box.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904539A (en) * | 2018-07-23 | 2018-11-30 | 广东永青生物科技有限公司 | Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge |
| CN109985014A (en) * | 2019-05-17 | 2019-07-09 | 贵州天安药业股份有限公司 | Hydrochloric acid glitazone dispersion piece is used in a kind for the treatment of of diabetes B |
| CN113349278A (en) * | 2021-06-16 | 2021-09-07 | 青岛三皇农业科技有限公司 | Functional food containing chitosan oligosaccharide |
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| CN103892025A (en) * | 2014-04-15 | 2014-07-02 | 太仓市伟基生物科技有限公司 | Throat-smoothing candy with functions of clearing heat and eliminating phlegm |
| CN104056070A (en) * | 2014-06-20 | 2014-09-24 | 苏州法莫生物技术有限公司 | Throat-moistening oral liquid |
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| CN103892025A (en) * | 2014-04-15 | 2014-07-02 | 太仓市伟基生物科技有限公司 | Throat-smoothing candy with functions of clearing heat and eliminating phlegm |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904539A (en) * | 2018-07-23 | 2018-11-30 | 广东永青生物科技有限公司 | Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge |
| CN109985014A (en) * | 2019-05-17 | 2019-07-09 | 贵州天安药业股份有限公司 | Hydrochloric acid glitazone dispersion piece is used in a kind for the treatment of of diabetes B |
| CN113349278A (en) * | 2021-06-16 | 2021-09-07 | 青岛三皇农业科技有限公司 | Functional food containing chitosan oligosaccharide |
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Application publication date: 20180420 |