CN108904539A - Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge - Google Patents
Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge Download PDFInfo
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- CN108904539A CN108904539A CN201810814585.9A CN201810814585A CN108904539A CN 108904539 A CN108904539 A CN 108904539A CN 201810814585 A CN201810814585 A CN 201810814585A CN 108904539 A CN108904539 A CN 108904539A
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- powder
- nacreous layer
- layer powder
- lozenge
- ulcer
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- 239000005017 polysaccharide Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract
The present invention relates to a kind of preparation methods for preventing and treating mouth ulcer lozenge, and in particular to pearl powder or nacreous layer powder and crystal diabetin composition are in the application for preparing mouth ulcer lozenge.The present invention is proposed by 1 ~ 2 part of nacreous layer powder, 2~5 parts of crystal diabetin one group of compositions can prevent and treat the buccal tablets of canker sore, to multiple, recurrent oral ulceration has prevention and therapeutic effect well, being added to several vitamins and addition the invention also discloses the composition has the glycyrrhiza uralensis fisch of anti-inflammatory, antibacterial, dark plum, Exocarpium Citri Rubrum, dandelion, the traditional Chinese medicine ingredients such as honeysuckle prepare the formula and processing technology of lozenge, the lozenge of anti-treating dental ulcer prepared by the present invention, have the function of antibacterial anti-inflammatory analgesic and promotes ulcer healing, it can be clinically used for the prevention and treatment of canker sore caused by a variety of causes, it can be used for gum swelling, pharyngitis, laryngitis, the prevention and treatment of the oral inflammations such as tonsillitis.
Description
Technical field
The present invention relates to a kind of preparation methods for preventing and treating mouth ulcer lozenge, and in particular to pearl powder or nacreous layer powder and knot
Brilliant fructose composite is in the application for preparing mouth ulcer lozenge.
Background technique
Canker sore is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in lip inside or bicker
Mucous membrane area, the positions such as this outer lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate are also common, due to the mucous membrane at these positions
Lack keratinization layer or angling is poor, occurs on the inside of lip or the canker sore in bicker mucous membrane area is typically all single-shot, head
It is bigger and deep, as a hollow place, the injustice of bottom slightly.The course of disease of the type canker sore is long, can leave after healing
Scar is the problem of patient most has a headache, and betides tongue, the canker sore of tongue abdomen position is also referred to as tongue ulcer.Canker sore
Sharp ache when breaking-out, local cusalgia is obvious, and serious person also will affect diet, speak, and causes very big inconvenience to daily life；It can
The constitutional symptoms such as concurrent halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, out of strength, irritated, fever, enlargement of lymph nodes.Mouthful
The occurrence cause of chamber ulcer is complicated, with systemic disease, local trauma, stress, food, drug, malnutrition, hormone water
Flat change and the factors such as vitamin or microelement deficiencies are related.Clinical application is in the Chinese and Western medicine and health care product type of canker sore
Various, common drug has analgesic, the ulcer surface cauterant etc. of clearing heat and detoxicating, swelling and pain relieving class Chinese medicine and chemical drug, commonly uses agent
Type has containing medicine film, a variety of dosage forms such as gargle, lozenge, powder spray, powder, and buccal tablets are due to being convenient for carrying and quality is steady
It is fixed, easy to use and be used widely.
The treatment existing drug of canker sore is disadvantageous in that at present：It is main chemical drugs with antibiotic and glucocorticoid
It is to be carried out for symptom anti-inflammatory and slow down pain, can reduce ulcer surface using chemical burns, but side effect is very big, Bu Nengcong
Fundamentally solve canker sore breaking-out.Traditional Chinese powder medicine class, powder spray class are mostly that medicinal powder or crude extract dry powder carry out ingredients,
Mouthfeel is bad, it is not easy to which in ulcer surface surface formation protective layer, administration, dosage is not easy to grasp；Medicine film drugloading rate is small, and
Ulcer surface is larger in oral cavity, unsuitable pad pasting administration when multiple ulcer；Gargle drug concentration is low, in oral cavity retention time
It is short, it is not likely to produce drug effect.In the market currently used for treat canker sore lozenge mostly with bitter taste, astringent taste medicinal material extract medicinal extract into
Row tabletting, there are it is buccal when poor taste, patient's compliance is bad, and oral administration biaavailability is low, dosage form absorb work it is slow, sucrose,
The auxiliary materials such as starch are easily adhered to ulcer surface, become the culture medium of bacteria breed, and bacterium is caused largely to be proliferated in ulcer surface, cause to burst
Ulcer face is not easy to heal.Therefore original treatment canker sore similar drug kind is not able to satisfy the need of canker sore crowd on present society
It wants, therefore is limited by very large in clinical use.
Pearl system Pteriidae animal Pinctada martensii Pteria martens (Dunker), Unionidae animal spinnaker
Stimulated point of bivalves animal of Hyriopsis cumingii (1ea) or cristaria plicata Crisrtaria plicata (Leach) etc.
The substance secreted is traditional one of Chinese medicine.With treat it is confused and worried, the long disunion of ulcer, skin maintenance and cosmetic benefits, promote longevity,
Solve taking poison and growing muscle due and other effects.Clinic also turns out it to cardiovascular and cerebrovascular disease, hypertension, diabetes, insomnia, constipation, osteoporosis, bone
Matter hyperplasia, old pain in waist and lower extremities etc. are significant in efficacy.Pearl nutritional ingredient rich in and all kinds of life source substances.Including：（1）Contain
18 kinds of amino acid, including 7 kinds of human bodies must need amino acid：Serine, valine, methionine, isoleucine, leucine, junket
Propylhomoserin, phenylalanine, lysine；The wherein adjustable human endocrine such as serine, valine, strengthen immunity and anti-aging.
It is the important material base that pearl plays given efficacy.(2) containing about 22 kinds of microelements such as selenium, there is important health care function
Effect, as selenium can enhance human immunity.（3）Calcium class containing 38%-40%, ion like calcium contained by Margarita hydrolyzed solution be then easier to for
Absorption of human body.Pearl powder and Margarita hydrolyzed solution are used to treat canker sore and have had history for a long time civil, through patent retrieval
The Chinese medicine compound prescription for the treatment of canker sore containing pearl powder or pearl Margarita hydrolyzed solution has nearly 60, and nacreous layer powder is for treating
Canker sore does not have for one then yet.In addition, being used to prepare the product of buccal tablets, both pearl powder and nacreous layer powder one does not have yet
Have.Nacreous layer powder is the powder cultivating the internal layer of the pearl oyster (shell) of pearl and wearing into, and nacreous layer powder is homologous, nacre with pearl powder
Powder other than main component is the calcium carbonate of aragonite structure, also contain various trace elements, protein (can be obtained after hydrolysis
18 kinds of amino acid, wherein 7 kinds are essential amino acids), 20 various trace elements and vitamin B.The ingredient knot of nacreous layer powder
Structure is essentially identical with pearl powder, and the type of amino acid is essentially identical in the type of amino acid and pearl powder in nacreous layer powder, due to
Nacreous layer powder is cheap and easy to get, replaces pearl powder with nacreous layer powder, preparing anti-treating dental ulcer is a very practical thinking.
Fructose is to be currently known one of carbohydrate most safe, most healthy present in nature, is widely present in fruit
In the foods such as honey.Fructose is faster than glucose in human body metabolism, is easy to be absorbed by organisms, and do not depend on insulin, to blood
Sugar influence very little, suitable for the patient of glucose metabolism and dyshepatia supplement energy, therefore crystal diabetin be diabetes patient,
The ideal sweetener of adiposis patient, infant foods.Have been demonstrated that, fructose there are also inhibit saprodontia characteristic, due to the humidity in oral cavity,
Temperature, nutriment easily breed various cause caries bacterias, and these bacteriums can utilize remaining sucrose, starch in oral cavity etc.
Polysaccharide food, the acidic materials of ferment, decompose, releasing corrosion tooth, the enamel of tooth can not only be destroyed by accumulating over a long period, also
Decayed tooth easy to form.It is demonstrated experimentally that crystal diabetin is not easy to be converted into acid by streptococcus in oral cavity, the bacterium can be inhibited to generate Portugal poly-
Therefore sugar, selects fructose substituting saccharose to be used for the preparation of buccal tablets to inhibit the generation of saprodontia, be optimal at present
Selection.We study and also confirm, contact of the fructose lozenge directly with oral ulcer surface, although having moment stimulation pain, very
The ulcer that will be improved, and individually occur fastly often can begin to rehabilitation at one day or so, multiple, serious oral cavity
Ulcer is just without being so easy, and this also illustrates itself is a the good medicine for the treatment of canker sore for fructose.
Summary of the invention
The present invention proposes, forms one group of buccal tablets that can prevent and treat canker sore by nacreous layer powder and fructose,
To multiple, recurrent oral ulceration has good protection and therapeutic effect, further research it has also been found that, in the compound, add
Add it is some have anti-inflammatory, the effect of the extract of antibacterial, the Chinese medicine of analgesic effect or Chinese medicine, anti-oral ulcer is more preferable, this hair
It is bright mention have anti-inflammatory, the Chinese medicine of antibacterial refers to Radix Glycyrrhizae, dark plum, Exocarpium Citri Rubrum, dandelion, the traditional Chinese medicine ingredients such as honeysuckle, in these
Medicine and its extract are added in buccal tablets that curative effect is better, often take, and can prevent the recurrence of canker sore, the present invention is also
Nacreous layer powder is replaced to prepare buccal tablets including application pearl powder and hydrolyzed pearl solution.
Specific embodiment：
The following is specific embodiments of the present invention, and technical scheme of the present invention is further described, but guarantor of the invention
Shield range be not limited to these examples, it is all be included in without departing substantially from the change of present inventive concept or equivalent substitute it is of the invention
Within protection scope.
Embodiment one
Pearl fructose mouth ulcer lozenge 1：Formula is by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, adhesive and lubricant
Appropriate composition；It is Ultramicro-powder that its production technology, which is nacreous layer powder crushing, equal with crystal diabetin, adhesive and mix lubricant
It is even, particle is made by spray drying process, tabletting to get.
The adhesive that this formula is mentioned refer to starch slurry, sodium carboxymethylcellulose, hydroxypropyl cellulose, methylcellulose and
Ethyl cellulose, hydroxypropyl methyl cellulose, gelatin, carbomer, povidone, one or more groups of polyvinylpyrrolidone etc.
It closes, lubricant refers to magnesium stearate.
Embodiment two
Pearl fructose mouth ulcer lozenge 2：Formula is by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, vitamin B2In right amount,
Appropriate folic acid, vitamin B12In right amount, appropriate pantothenic acid, adhesive and lubricant form in right amount；Its production technology is nacreous layer powder
Crushing is Ultramicro-powder, uniform with crystal diabetin, adhesive and mix lubricant, is made particle by spray drying process, tabletting, i.e.,
?.
" the vitamin B mentioned in the present embodiment2In right amount, appropriate folic acid, vitamin B12In right amount, appropriate pantothenic acid " refers to the work
When skill is prepared as buccal tablets, every lozenge contains vitamin B25~10 milligrams, 0.1~0.4 milligram of folic acid, vitamin B12
0.5~3 microgram, appropriate 5~10 milligrams of pantothenic acid.
Embodiment three
Pearl fructose mouth ulcer lozenge 3：Formula is by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, 1 part of dark plum, Radix Glycyrrhizae 3
Part, 1 part of dried orange peel composition；Its production technology is that nacreous layer powder is crushed is Ultramicro-powder, and dark plum, Radix Glycyrrhizae, dried orange peel heats with 70% ethyl alcohol
Refluxing extraction twice, 1.5 hours every time, filters while hot, and filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.32（60~
65℃）, it is dried under reduced pressure；Filter residue adds water boiling twice, 2 hours for the first time, second 1.5 hours, merges steaming liquid, filters, filter
Liquid is concentrated into relative density 1.30~1.32（60~65 DEG C）Medicinal extract, be dried under reduced pressure, merge with alcohol extract, two kinds of fine powders,
Nacreous layer powder is uniformly mixed with crystal diabetin, is made particle by spray drying process, tabletting to get.
Example IV
Pearl fructose mouth ulcer lozenge 4：Formula is by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, 1 part of honeysuckle, Radix Glycyrrhizae 3
Part, 1 part of Exocarpium Citri Rubrum composition；Its production technology is that nacreous layer powder is crushed is Ultramicro-powder, and honeysuckle, Radix Glycyrrhizae, Exocarpium Citri Rubrum adds with 70% ethyl alcohol
Circumfluence distillation twice, 1.5 hours every time, filters while hot, and filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.32（60
~65 DEG C）, it is dried under reduced pressure；Filter residue adds water boiling twice, 2 hours for the first time, second 1.5 hours, merges steaming liquid, filters,
Filtrate is concentrated into relative density 1.30~1.32（60~65 DEG C）Medicinal extract, be dried under reduced pressure, merge with alcohol extract, two kinds thin
Powder, nacreous layer powder are uniformly mixed with crystal diabetin, are made particle by spray drying process, tabletting to get.
Embodiment five
Pearl fructose mouth ulcer lozenge 5：Formula is by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, 1 part of honeysuckle, Radix Glycyrrhizae 3
Part, 1 part of dandelion, composition；Its production technology is that nacreous layer powder is crushed is Ultramicro-powder, and honeysuckle, Radix Glycyrrhizae, dandelion is with 70%
Ethyl alcohol heating and refluxing extraction twice, 1.5 hours every time, filters while hot, filtrate recycling ethanol and be concentrated into relative density 1.30~
1.32（60~65 DEG C）, it is dried under reduced pressure；Filter residue adds water boiling twice, 2 hours for the first time, second 1.5 hours, merges and steams
Liquid, filtering, filtrate are concentrated into relative density 1.30~1.32（60~65 DEG C）Medicinal extract, be dried under reduced pressure, merge with alcohol extract,
Two kinds of fine powders, nacreous layer powders are uniformly mixed with crystal diabetin, are made particle by spray drying process, tabletting to get.
In the embodiment of front 5, nacreous layer powder can use pearl powder, Superfine pearl powder in formula, and Nano pearl powder is received
Rice nacreous layer powder, hydrolyzed pearl solution, pearl layer powder hydrolysate replace.
It, should by nacreous layer powder and fructose composite in the lozenge for preparing anti-treating dental ulcer described in the embodiment of front 5
Also toffee, hard candy, soft sweets, crisp sweets and chewing gum can be made according to the production technology for preparing candy in formula.
It, should by nacreous layer powder and fructose composite in the lozenge for preparing anti-treating dental ulcer described in the embodiment of front 5
Formula can also be made according to the production technology of pharmacy containing medicine film, gargle, powder spray, powder, oral solution, granule.
By nacreous layer powder and fructose composite in the lozenge for preparing anti-treating dental ulcer, tool described in the embodiment of front 5
There is antibacterial anti-inflammatory analgesic and promote ulcer healing, can be clinically used for the prevention of canker sore caused by a variety of causes and control
It treats, can be used for gum swelling, pharyngitis, laryngitis, the prevention and treatment of the oral inflammations such as tonsillitis.We are to canker sore
Some patientss carried out preliminary observation, obtain well-content effect.
Claims (10)
1. the application that nacreous layer powder and fructose composite prevent and treat mouth ulcer lozenge in preparation.
2. prevent and treat the application of mouth ulcer lozenge in preparation by nacreous layer powder and fructose composite as described in claim 1,
It is characterized in its formula by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, adhesive and lubricant form in right amount；Its production technology
Be nacreous layer powder crush be Ultramicro-powder, it is uniform with crystal diabetin, adhesive and mix lubricant, be made up of spray drying process
Particle, tabletting to get.
3. prevent and treat the application of mouth ulcer lozenge in preparation by nacreous layer powder and fructose composite as described in claim 1,
Be characterized in its formula by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, vitamin B2In right amount, appropriate folic acid, vitamin B12It is suitable
Amount, appropriate pantothenic acid, adhesive and lubricant form in right amount；It is Ultramicro-powder that its production technology, which is nacreous layer powder crushing, with crystallization
Fructose, adhesive and mix lubricant are uniform, are made particle by spray drying process, tabletting to get.
4. prevent and treat the application of mouth ulcer lozenge in preparation by nacreous layer powder and fructose composite as described in claim 1,
It is characterized in its formula by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, 1 part of dark plum, 3 parts of Radix Glycyrrhizae, 1 part of dried orange peel forms；It is given birth to
Production. art be nacreous layer powder crush be Ultramicro-powder, dark plum, Radix Glycyrrhizae, dried orange peel with 70% ethyl alcohol heating and refluxing extraction twice, every time
It 1.5 hours, filters while hot, filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.32（60~65 DEG C）, it is dried under reduced pressure；Filter
Slag adds water boiling twice, 2 hours for the first time, second 1.5 hours, merges steaming liquid, filtering, filtrate is concentrated into relative density
1.30~1.32（60~65 DEG C）Medicinal extract, be dried under reduced pressure, merge with alcohol extract, two kinds of fine powders, nacreous layer powder and crystallization fruit
Sugar is uniformly mixed, and is made particle by spray drying process, tabletting to get.
5. prevent and treat the application of mouth ulcer lozenge in preparation by nacreous layer powder and fructose composite as described in claim 1,
It is characterized in its formula by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, 1 part of honeysuckle, 3 parts of Radix Glycyrrhizae, 1 part of Exocarpium Citri Rubrum forms；Its
Production technology be nacreous layer powder crush be Ultramicro-powder, honeysuckle, Radix Glycyrrhizae, Exocarpium Citri Rubrum with 70% ethyl alcohol heating and refluxing extraction twice, often
It secondary 1.5 hours, filters while hot, filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.32（60~65 DEG C）, it is dried under reduced pressure；
Filter residue adds water boiling twice, 2 hours for the first time, second 1.5 hours, merges steaming liquid, filtering, filtrate is concentrated into relative density
1.30~1.32（60~65 DEG C）Medicinal extract, be dried under reduced pressure, merge with alcohol extract, two kinds of fine powders, nacreous layer powder and crystallization fruit
Sugar is uniformly mixed, and is made particle by spray drying process, tabletting to get.
6. prevent and treat the application of mouth ulcer lozenge in preparation by nacreous layer powder and fructose composite as described in claim 1,
It is characterized in that its formula by 1~2 part of nacreous layer powder, 2~5 parts of crystal diabetin, 1 part of honeysuckle, 3 parts of Radix Glycyrrhizae, 1 part of dandelion, forms；
Its production technology is nacreous layer powder to be crushed for Ultramicro-powder, honeysuckle, Radix Glycyrrhizae, 70% ethyl alcohol heating and refluxing extraction two of dandelion
It is secondary, it 1.5 hours every time, filters while hot, filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.32（60~65 DEG C）, decompression
It is dry；Filter residue adds water boiling twice, 2 hours for the first time, second 1.5 hours, merges steaming liquid, filtering, filtrate is concentrated into phase
To density 1.30~1.32（60~65 DEG C）Clear cream, be dried under reduced pressure, merge with alcohol extract, two kinds of fine powders, nacreous layer powder with
Crystal diabetin is uniformly mixed, and is made particle by spray drying process, tabletting to get.
7. preparing containing for anti-treating dental ulcer by nacreous layer powder and fructose composite described in 3,4,5,6 such as claim 2
Piece, wherein nacreous layer powder can use pearl powder, Superfine pearl powder, Nano pearl powder, Nanometer Pearl Layer Powder, hydrolyzed pearl solution, treasure
Pear powder layer hydrolyzate replaces.
8. such as claim 2, by nacreous layer powder and fructose composite in the lozenge for preparing anti-treating dental ulcer described in 3,4,5,6
Application, which can also be made toffee, hard candy, soft sweets, crisp sweets and chewing gum according to the production technology for preparing candy.
9. such as claim 2, by nacreous layer powder and fructose composite in the lozenge for preparing anti-treating dental ulcer described in 3,4,5,6
Application, which can also be made according to the production technology of pharmacy containing medicine film, gargle, powder spray, powder, oral solution,
Granule.
10. as claimed in claim 3 by nacreous layer powder and fructose composite in the lozenge for preparing anti-treating dental ulcer, formula
In the vitamin B mentioned2In right amount, appropriate folic acid, vitamin B12In right amount, pantothenic acid refers to that the technique is prepared as buccal tablets in right amount
When, every lozenge contains vitamin B25~10 milligrams, 0.1~0.4 milligram of folic acid, vitamin B120.5~3 microgram, pantothenic acid
Appropriate 5~10 milligrams.
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| CN201810814585.9A CN108904539A (en) | 2018-07-23 | 2018-07-23 | Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111000772A (en) * | 2019-12-31 | 2020-04-14 | 广州市香雪制药股份有限公司 | New use of exocarpium Citri Grandis extract |
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