CN103768438A - Traditional Chinese medicinal desensitization bamboo salt chewing gum and preparation method thereof - Google Patents
Traditional Chinese medicinal desensitization bamboo salt chewing gum and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicinal desensitization bamboo salt chewing gum, which is prepared by the following methods: drying sea salt for later use, mixing calcined oyster, Drynaria fortunei, rehmannia glutinosa and indigo naturalis with the sea salt, adding fresh Dendrocalamus segments, and sealing with yellow mud; and calcining in a high temperature refractory kiln; and cooling to obtain traditional Chinese medicinal desensitization bamboo salt, dissolving the traditional Chinese medicinal desensitization bamboo salt in a Rhizoma coptidis extractive solution, centrifuging, collecting supernatant, adding a sweetener Neotame to remove bitter taste of Rhizoma coptidis liquid, and preparing the traditional Chinese medicinal desensitization bamboo salt chewing gum according to traditional chewing gum preparation process. The traditional Chinese medicinal desensitization bamboo salt chewing gum disclosed by the invention can not only clean oral cavity and keep mouth fresh, but also can effectively block off dentinal tubules, and treat dentin hypersensitivity; further, the traditional Chinese medicinal desensitization bamboo salt chewing gum has a distinct inhibitory effect on several common oral pathogens, and can prevent and treat dental caries and periodontitis to a certain extent.
Description
Technical field
The present invention relates to a kind of Chinese medicine desensitization bamboo salt chewing gum and preparation method thereof.
Background technology
Chewing gum is the basis take natural gum or glycerol resin as colloid, a kind of people of confession that add the mediation compactings such as syrup, Herba Menthae, sweeting agent to form put into mouth and chew a kind of saccharide that liked by the people of the world of stinging, it is not only nice but also joyful, liked by child and adolescence, also become simultaneously most ofly youthfully play cool, the new lover of fashion.The substrate stickiness of chewing gum is very strong.Can remove the food debris of dental surface, the mechanical stimulus of masticatory movement can increase again the secretion of saliva, rinses oral surfaces, there is the effect of certain cleaning oral cavity, chew gum, has promoted the exercise of facial blood circulation and muscle, and the growth of tooth jaw face is had to facilitation.When chew gum, salivation increases, can facilitating digestion.The nearest research of Japan scientist shows, all right temporary transient memory that improves of chewing gum.
Dental hypersensitiveness refers to when the dentin part exposing on tooth is subject to machinery, chemistry or thermal stimulus, the symptom of a kind of special acid of generation, soft, pain.Current more scholar adopts hydrodynamics to explain in fact the pain phenomenon of dental hypersensitiveness: after dentin exposes, and the liquid in dentinal tubule, the mechanicalness reaction that dentin liquid stimulates to external world.While accepting cold stimulation, dentin liquid flows from inside to outside, and while being subject to thermostimulation, ecto-entad flows.Odontoblast's film is very responsive with unexpected pressure variation to flowing of this liquid, then causes diastole and the compression of dentin cell and projection, can cause pain symptom through Intradental nerve tip conduction around.Therefore, thus shutoff dentinal tubule alleviates or eliminates the ultimate principle that stimulates on dentin liquid stream moving impact to become the medicines of great majority treatments hyperesthesia of dentin.At present, medicine kind and the method for the treatment of dentine hypersensitivity are a lot, but Chinese medicine and the compound Therapeutic Method of making desensitizing gum of bamboo salt are reported fewer.
Bamboo salt is the material with health care and medicinal curative effect of making through special process take sea salt and bamboo as raw material.Ancient Times in China just has the record about bamboo salt preparation method.Sea salt is put in fresh thick bamboo tube, seals thick bamboo tube two ends with yellow mud, high-temperature baking, makes the sea salt in thick bamboo tube be combined with Succus Bambusae, the dehydration that then heats up, multiple high temp calcining.The bamboo salt obtaining with this technique can be used as by " digestive pharmaceutical " in the time of dyspepsia, when injured, as " hemorrhage ", can also brush teeth, and washes eye.Modern scientific research shows, Succus Bambusae contains various trace elements, as silicon, zinc, selenium, germanium, ferrum etc.; Contain and enrich vitamin and polysaccharide, can enhance metabolism, activating human body cells, makes function of human body reach a stable equilibrium, thereby maintenance health, has that toxin expelling relieves the effect of alcohol, skin care, relieving cough and resolving phlegm, hemostasis disappear hemorrhoid, many effects such as disappear lipoid and reducing blood pressure, cancer-resisting etc.Bamboo salt also has application aspect oral cavity health, as bamboo salt toothpaste.The curative mechanism of bamboo salt is: 1, bamboo salt solution is alkalescence, and under the same terms, its pH value is than high approximately 0.5 left and right of salt solution.The normal pH value of human body fluid is 7.3～7.4.Therefore, take in appropriate bamboo salt every day, can in and unnecessary acid in body, as gastric acid, lactic acid, uric acid etc., thereby performance regulates the effect of pH value of human body; 2, the electrical conductivity of bamboo salt is lower than the electrical conductivity of Sal, and its penetration is strong, easily enters cell, is convenient to dissolve the refuse of piling up in human body; 3, sea salt condensing crystallizing, in sea water, is rich in number of chemical element, as Cl, Na, Mg, S, Ca, K, Br, C, Sr, B, F etc.In calcination process, the trace element in bamboo, loess, fuel also can be joined and enter into, and as silicon, zinc, selenium, germanium, ferrum, has also increased the micronutrient levels in bamboo salt, and these trace element are all needed by human body materials.
Concha Ostreae contains 80%～95% calcium carbonate, calcium phosphate, and " Chinese Pharmacopoeia " nineteen ninety-five version is defined as " get clean Concha Ostreae, be calcined to crisp according to method of direct calcination " to the process of preparing Chinese medicine of Concha Ostreae (calcined).Concha Ostreae (calcined) has the effect of the astringent or styptic treatment for spontaneous sweating deacidification of convergence, can be used for that treatment has a stomach-ache, gastric acid etc.
Rhizoma Drynariae, is the rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi or drynaria baronii Diels, and calcium content is higher.Compendium of Material Medica is recorded: " controlling tinnitus and the chronic diarrhea of suffering from a deficiency of the kidney, toothache ".This product energy promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, reunion of fractured tendons and bones, warming and recuperating the kidney-YANG, also can be used for the treatment of the diseases such as toothache, alopecia areata, vitiligo.
Indigo Naturalis is the Powdered thing that stem, the leaves such as Acanthaceous indigo, Folium et Caulis Indigoferae Tinctoriae, polygonum tinctorium ait., Isatis indigotica Fort. are processed into through traditional handicraft, and fluorinated volume is higher.Have removing fire from the liver, effect of heat clearing away, removing heat from blood, removing toxic substances, also has stronger inhibitory action to staphylococcus aureus, Staphylococcus albus, alpha streptococcus, meningococcus.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, toothache, aphtha, mumps, sore throat, pediatric epilepsy scared.
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant.Radix Rehmanniae is slowly cured to approximately most probably doing i.e. " Radix Rehmanniae ".Radix Rehmanniae fluorinated volume is higher, has clearing away heat and cooling blood, effect of YIN nourishing and the production of body fluid promoting.Control fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation, chews Radix Rehmanniae and can also treat toothache.
Rhizoma Coptidis is cohosh, the rhizome of Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.There is heat clearing and damp drying, effect of eliminating fire and detoxication.A lot of research shows, Rhizoma Coptidis has preventive and therapeutic action to oral cavity bacterial infection disease, the multiple oral cavity common pathogens such as staphylococcus aureus, Candida albicans, Streptococcus mutans, porphyromonas gingivalis, bacterium actinomycetem comitans, streptococcus sobrinus are had to stronger inhibitory action, aspect the preventing and treating of dental caries and periodontal disease, there are bright prospects.Its main antipathogenic composition is berberine, can suppress the oxidative deamination process of acetone acid, and this process is the glycometabolic intermediate link of yeast and antibacterial.The berberine of higher concentration also can suppress mixing of Nucleic acid precurser, thereby anti-bacteria nucleic acid is synthetic.
Neotame is a kind of novel sweetener by the special Developed of U.S.'s knob, chemical name N-[N-(3,3-dimethylbutyl)-L-α-asparagine-L-Phe 1-methyl ester, 2002, U.S. FDA is examined by food additives, allows neotame to be applied in all food and beverage.2003, ministry of Health of China approval neotame was common in various Food & Drink as sweeting agent, was that China's " food additive sanitary standard " is unique without scope of application restriction, without the high sweetener of use amount restriction.Its sugariness is 8000 times of left and right of Saccharum Sinensis Roxb., and sugariness cost is low, is called as the emperor in sweeting agent.Sweet taste is pure, fresh and clean, and sweet taste is long, and contained nutrient substance is easily absorbed by the body.Low-yield or the noenergy of neotame, can supply diabetes patient, can not cause blood glucose fluctuation, and unlikely dental caries can promote bacillus bifidus propagation, is the first-selected sweeting agent of health-related food.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of Chinese medicine desensitization bamboo salt chewing gum that is used for the treatment of dentine hypersensitivity, the present invention also provides its preparation method.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine desensitization bamboo salt chewing gum, prepares by the following method:
(1) get 30～34 parts of sea salt dry powder, 30～32 parts of Concha Ostreae (calcined)s, 1～4 part of Rhizoma Drynariae, 30～32 parts of Indigo Naturaliss, 1～4 part of Radix Rehmanniae, mix, pulverize, obtain mixed powder, by weight;
Described sea salt dry powder prepares by the following method: get sea salt, dry the percetage by weight to moisture≤1%(at 150 ℃～200 ℃), pulverize, obtain sea salt dry powder, for subsequent use;
Described sea salt, refers in the open under environment, relies on the radiant heat of the sun, makes sea water in large-area salt pan, by natural evaporation, and progressively concentrated salt of analysing salt and obtain.
(2) (bamboo section is by sweet bamboo one-tenth: select new fresh and sweet bamboo to get bamboo section, be cut into the bamboo section that length is identical, each bamboo section retains a ring, this is conventional method, repeat no more), to adding mixed powder (the shared volume of mixed powder is advisable to account for 30～70% of bamboo section volume, 50% the best) in it, then with mud sealing (preferably natural free of contamination yellow mud; Yellow mud refers to the semifluid that yellow mud and water mix);
(3) the above-mentioned bamboo section with mud sealing is placed in to pottery, to the Colophonium that adds sea salt dry powder weight 5% in pottery, then carrying out high-temperature calcination (sends in high-temperature flame-proof kiln and calcines, when calcining, pottery is added a cover, but blow-by), calcine 20 hours for 900～1100 ℃, then temperature is brought up to 1500 ℃ of calcinings 4 hours, made salt fusing; After calcining, naturally cool to room temperature (opening high-temperature flame-proof kiln ventilates cooling), take out pottery, from bamboo section, take out the bamboo salt that has become crystal bulk, after pulverizing, obtain the bamboo salt that desensitizes;
(4) get Rhizoma Coptidis, add water to submerge, soak 10～20 hours, decoct 30min, filter to get filtrate and filtering residue, in filtering residue, add water again, decoct 30min, filter to get filtrate and filtering residue, filtering residue repeats to decoct once (decocting 30min) again, filters to get filtrate and filtering residue; Merge the filtrate of three times, be concentrated into 0.2g/ml(by crude drug amount), obtain Rhizoma Coptidis extract;
(5) desensitization bamboo salt is joined in Rhizoma Coptidis extract, heating is dissolved it, and the concentration of desensitization bamboo salt is 0.1g/ml, and the centrifugal 30min of 1200r/min, gets supernatant; In supernatant, add sweeting agent neotame, heating is dissolved it, and the concentration of sweeting agent is 0.03g/ml, obtains chewing gum solvent;
(6) in 5g chewing gum solvent, add 5g gum base, 0.5g plasticizer, 1.2g emulsifying agent, 0.8g spice, makes chewing gum according to traditional chewing gum processing technology, to obtain final product.
Preferably 3～5 years age of bamboo of described new fresh and sweet bamboo, and appearance light is emerald green, there is no insect pest, and injury-free.Adopt so sweet bamboo, its Succus Bambusae is fresh sweet, nutritious.In Succus Bambusae, contain the nutrient substances such as several amino acids (take glutamic acid, arginine, alanine, aspartic acid and serine as many), trace and macroelement (sodium, magnesium, calcium, potassium, manganese, zinc, copper, ferrum etc.), polysaccharide (fructose, glucose, mannose and arabinose etc.) and water soluble vitamins VB1VC, nicotinic acid, folic acid, especially body-care is worth to very high flavonoid content very high, have that nutrition is moistened, heat clearing away, removing toxic substances, diuresis, antitumor, improve the health-care effects such as body immunity.
Described sweeting agent neotame is provided by Si Weite bio tech ltd, Jinan, is a kind of novel sweetener of the special Developed of U.S. knob, can effectively suppress Rhizoma Coptidis extract with bitterness, eliminate the discomfort of patient in using.
Described gum base, plasticizer, emulsifying agent and spice are conventional products of the prior art, can conventional commercial obtaining, the present invention's gum base used is hydrogenated rosin glyceride, has good mouthfeel and non-oxidizability, can extend the shelf-life of chewing gum, and keep soft, fine and smooth mouthfeel; The present invention's plasticizer used is solid edible paraffin, and main component is the normal paraffin of 20～30 carbon atoms, as the softening processing of rubber in gum base, makes elastomeric rubber have plasticity; The present invention's emulsifying agent used is glyceryl monostearate (HLB3.8), by using emulsifying agent to make gum base even tissue, prevents from sticking to one's teeth, and reduces the high molecular elasticity of colloid, regulates hardness, plays emollescence; The spice flavor three triacetin vinegar that the present invention is used, affine good with gum base, can soften to a certain extent gum base, make gum base be rich in elastoplasticity, smooth mouth feel exquisiteness.
The desensitization bamboo salt that the present invention prepares is light grey fine-powdered, and taste is salty; Desensitizing gum is light yellow, and taste is sweet.
The preparation method of described Chinese medicine desensitization bamboo salt chewing gum, the same.
Chinese medicine of the present invention desensitization bamboo salt chewing gum, after use, can not only cleaning oral cavity health, keep breath freshening, the more important thing is that it can be used for the treatment of dentine hypersensitivity, also there is obvious inhibitory action for several frequently seen pathogenic bacterium in oral cavity.When concrete application, if chew desensitization bamboo salt chewing gum each two hours, one day twice, general two to three months can take effect, and responsive symptom greatly alleviates.
The present invention is by useful to oral cavity health and be easy to a few herbs Concha Ostreae (calcined), Rhizoma Drynariae, the Radix Rehmanniae, Indigo Naturalis and the sea salt mixed calcining of absorption of human body, then Chinese medicine desensitization bamboo salt and Rhizoma Coptidis extract and the sweeteners obtaining cooling has been prepared into the Chinese medicine bamboo salt chewing gum that desensitizes, effect of Concha Ostreae (calcined), Rhizoma Drynariae, the Radix Rehmanniae, Indigo Naturalis is dissolved in bamboo salt, is jointly brought into play oral disease therapeutic and oral cavity health effect.Chinese medicine desensitization effectively shutoff dentinal tubule of bamboo salt chewing gum prepared by the present invention, treatment dentine hypersensitivity, there is obvious inhibitory action for several frequently seen pathogenic bacterium in oral cavity, can prevent and treat to a certain extent dental caries and periodontal disease, cleaning oral cavity health, and the discomforts such as the original bitterness of Chinese medicine are removed, facilitate patient to use voluntarily, be easy to carry, can there is no cariogenicity for diabetic, human body being had no side effect, also there is no the phenomenon such as allergy, stimulation, is a kind of health food healthy and helpful to oral cavity that integrates bamboo salt and Chinese medicine advantage.
Accompanying drawing explanation
Fig. 1: the Electronic Speculum figure of transverse section after normal saline processing dentin.
Fig. 2: the Electronic Speculum figure of vertical section after normal saline processing dentin.
From Fig. 1, Fig. 2, under normal saline is processed, most dentinal tubules are sealed.
Fig. 3: the Electronic Speculum figure of transverse section after collutory processing dentin.
Fig. 4: the Electronic Speculum figure of vertical section after collutory processing dentin.
From Fig. 3, Fig. 4, after collutory is processed, there is fluoride deposition in part dentinal tubule, and sealing process embodies to some extent.
Fig. 5: the Electronic Speculum figure of transverse section after sodium fluoride processing dentin.
Fig. 6: the Electronic Speculum figure of vertical section after sodium fluoride processing dentin.
From Fig. 5, Fig. 6, after sodium fluoride is processed, there is fluoride deposition in most dentinal tubules, and the nearly enamel end of vertical section tubule sealing process is obvious.
Fig. 7: the Electronic Speculum figure of transverse section after Chinese medicine desensitization bamboo salt chewing gum solvent processing dentin.
Fig. 8: the Electronic Speculum figure of vertical section after Chinese medicine desensitization bamboo salt chewing gum solvent processing dentin.
From Fig. 7, Fig. 8, after Chinese medicine desensitization bamboo salt chewing gum solvent processing, most dentinal tubules are fluorinated thing sealing, and the nearly enamel end of vertical section tubule sealing process is comparatively obvious.
Fig. 9: the bacteriostatic test result of Chinese medicine desensitization bamboo salt chewing gum solvent to staphylococcus aureus, in figure, 1 is normal saline group, antibacterial ring is 0mm; 2 is collutory group, and antibacterial ring is 6.6mm; 3 is how happy fluorine group, and antibacterial ring is 0mm; 4 is penicillin group, and antibacterial ring is 18.6mm; 5 is desensitization bamboo salt chewing gum group of solvents, and antibacterial ring is 8.6mm; As seen from the figure, the effect of Chinese medicine desensitization bamboo salt chewing gum solvent inhibition staphylococcus aureus is comparatively obvious.
Figure 10: the bacteriostatic test result of Chinese medicine desensitization bamboo salt chewing gum solvent to Candida albicans, in figure, 1 is normal saline group, antibacterial ring is 0mm; 2 is collutory group, and antibacterial ring is 3.6mm; 3 is how happy fluorine group, and antibacterial ring is 0mm; 4 is nystatin group, and antibacterial ring is 14.6mm; 5 is desensitization bamboo salt chewing gum group of solvents, and antibacterial ring is 8.6mm; As seen from the figure, Chinese medicine desensitization bamboo salt chewing gum solvent is obvious to the inhibitory action of Candida albicans.
Figure 11: the result of Chinese medicine desensitization bamboo salt chewing gum solvent to Streptococcus mutans bacteriostatic test, in figure, 1 is normal saline group, antibacterial ring is 0mm; 2 is collutory group, and antibacterial ring is 6.6mm, and 3 is how happy fluorine group, and antibacterial ring is 2.6mm, and 4 is penicillin group, and antibacterial ring is 26.6mm; 5 is desensitization bamboo salt chewing gum group of solvents, and antibacterial ring is 3.6mm; ; As seen from the figure, Chinese medicine desensitization bamboo salt chewing gum solvent is obvious to the inhibitory action of Streptococcus mutans.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1 prepares Chinese medicine desensitization bamboo salt chewing gum
Step is as follows:
(1) get 32 grams of sea salt dry powder, 31 grams of Concha Ostreae (calcined)s, 3 grams of Rhizoma Drynariae, 31 grams of Indigo Naturaliss, 3 grams of Radix Rehmanniae, mix, pulverize, obtain mixed powder;
Described sea salt dry powder prepares by the following method: gets sea salt, at 150 ℃～200 ℃, dries to moisture≤1%, pulverize, obtain sea salt dry powder, and for subsequent use;
(2) (bamboo section is by sweet bamboo one-tenth: select new fresh and sweet bamboo to get bamboo section, be cut into the bamboo section that length is identical, each bamboo section retains a ring), to adding mixed powder (the shared volume of mixed powder account for bamboo section volume 50%) in it, then seal with yellow mud;
(3) the above-mentioned bamboo section with mud sealing is placed in to pottery, to the Colophonium that adds sea salt dry powder weight 5% in pottery, then send in high-temperature flame-proof kiln and calcine, when calcining, pottery is added a cover, but blow-by, calcine 20 hours for 1000 ℃, then add Masson Pine as fuel, temperature is brought up to 1500 ℃ of calcinings 4 hours, make salt fusing; After having calcined, open the ventilation of high-temperature flame-proof kiln and be cooled to room temperature, take out pottery, take out the bamboo salt that has become crystal bulk from bamboo section, obtain the bamboo salt that desensitizes after pulverizing, be light grey fine-powdered, taste is salty;
(4) get 200 grams of Rhizoma Coptidis, add water to submerge, soak 15 hours, decoct 30min, filter to get filtrate and filtering residue, in filtering residue, add water again, decoct 30min, filter to get filtrate and filtering residue, filtering residue repeats to decoct once (decocting 30min) again, filters to get filtrate and filtering residue; Merge the filtrate of three times, be concentrated into 1000ml(and be equivalent to crude drug amount 0.2g/ml), obtain Rhizoma Coptidis extract;
(5) desensitization bamboo salt is joined in Rhizoma Coptidis extract, heating is dissolved it, and the concentration of desensitization bamboo salt is 0.1g/ml, and the centrifugal 30min of 1200r/min, gets supernatant; In supernatant, add sweeting agent neotame, heating is dissolved it, and the concentration of sweeting agent is 0.03g/ml, obtains chewing gum solvent;
(6) in 5g chewing gum solvent, add 5g gum base, 0.5g plasticizer, 1.2g emulsifying agent, 0.8g spice, according to traditional chewing gum processing technology, obtains Chinese medicine desensitization bamboo salt chewing gum of the present invention.
Be 3～5 years bamboo age of described new fresh and sweet bamboo, and appearance light is emerald green, there is no insect pest, injury-free.
Described sweeting agent neotame is a kind of novel sweetener of the special Developed of U.S.'s knob.
The present invention's gum base used is hydrogenated rosin glyceride; The present invention's plasticizer used is solid edible paraffin; The present invention's emulsifying agent used is glyceryl monostearate (HLB3.8); The spice flavor three triacetin vinegar that the present invention is used.
Embodiment 2 prepares Chinese medicine desensitization bamboo salt chewing gum
Step is with embodiment 1, and difference is: in step (1), and the consisting of of mixed powder: 32 grams of sea salt dry powder, 33 grams of Concha Ostreae (calcined)s, 1 gram of Rhizoma Drynariae, 33 grams of Indigo Naturaliss, 1 gram of Radix Rehmanniae.
Step is with embodiment 1, and difference is: in step (1), and the consisting of of mixed powder: 34 grams of sea salt dry powder, 30 grams of Concha Ostreae (calcined)s, 3 grams of Rhizoma Drynariae, 30 grams of Indigo Naturaliss, 3 grams of Radix Rehmanniae.
Embodiment 4 prepares Chinese medicine desensitization bamboo salt chewing gum
Step is with embodiment 1, and difference is: in step (1), and the consisting of of mixed powder: 30 grams of sea salt dry powder, 32 grams of Concha Ostreae (calcined)s, 3 grams of Rhizoma Drynariae, 32 grams of Indigo Naturaliss, 3 grams of Radix Rehmanniae.
Effect and the inhibiting bacteria and diminishing inflammation effect of test example Chinese medicine desensitization bamboo salt chewing gum treatment dentine hypersensitivity
(1) treatment dentine hypersensitivity
The Chinese medicine adding in Chinese medicine desensitization bamboo salt chewing gum product of the present invention is all rich in calcium or fluorine element, can be in conjunction with forming fluoride precipitation, by the dentinal tubule sealing exposing, reduce or avoid flowing of little liquid in pipe, thereby alleviate or eliminate the mobile stimulation to dental pulp of TF.And bamboo salt electrical conductivity is low, osmosis is good, can effectively enter dentinal tubule, makes to precipitate better sealing tubule.The inventor coats chewing gum solvent (prepared by embodiment 1) to expose Dentinal natural facing effect one hour, set normal saline, collutory, three groups of matched groups of sodium fluoride simultaneously, and the dentin transect and vertical section of several groups of Isolated Tooths after effect is carried out to scanning electron microscopic observation, result demonstration, the dentinal tubule of chewing gum group of solvents and sodium fluoride group has all obtained effective sealing.As Fig. 1～8, show the shutoff situation of processing rear dentinal tubule transverse section and vertical section under Electronic Speculum by different material.
(2) inhibiting bacteria and diminishing inflammation effect
The Chinese medicine containing in Chinese medicine desensitization bamboo salt chewing gum of the present invention and bamboo salt have the effect of certain inhibition growth to common pathogen in oral cavity, the bamboo salt solution of meta-alkalescence can regulate pH value, thus the diseases such as the inflammation that effectively prevention or treatment cause because of oral cavity common pathogen.The berberine containing in Rhizoma Coptidis extract can suppress the oxidative deamination process of acetone acid, and this process is the glycometabolic intermediate link of yeast and antibacterial.The berberine of higher concentration also can suppress mixing of Nucleic acid precurser, thereby anti-bacteria nucleic acid is synthetic.The Chinese medicine desensitization bamboo salt chewing gum solvent that the inventor prepares with embodiment 1 has carried out bacteriostatic experiment, and be provided with corresponding positive control and negative control group, result shows, chewing gum solvent product of the present invention is to staphylococcus aureus, Candida albicans, the growth of three kinds of common oral cavity pathogens such as Streptococcus mutans has obvious inhibitory action, and Fig. 9,10,11 has shown that chewing gum solvent of the present invention is to three kinds of inhibiting antibacterial rings of oral cavity common pathogen.
Application example:
Example 1: the Qin so-and-so, man, 28 years old, Jinan, Shandong Province people, because sleep bruxism causes occlusal wear serious, dentin exposes, caloric stimulation sensitivity is used Chinese medicine of the present invention desensitization bamboo salt chewing gum (prepared by embodiment 1), hyposensitiveness after three months in May, 2013.
Example 2: Shen, female, 38 years old, people from Linyi, Shandong, because of once row periodontal scaling of periodontitis, caloric stimulation sensitivity, and patient's periodontal disease is obvious.Use Chinese medicine desensitization bamboo salt chewing gum of the present invention (prepared by embodiment 1) in July, 2013, one day three times, after four months, responsive symptom is clearly better, and caloric stimulation alleviates greatly, and periodontal disease is also alleviated to some extent.
Example 3: river so-and-so, man, 42 years old, Jinan, Shandong Province people, cause 13,23 wedge shaped defect because teeth brushing way is improper, another this patient's jaw power more roughly tooth is closed face and is slightly worn away readme and often have caloric stimulation sense of discomfort, applies Chinese medicine desensitization bamboo salt chewing gum of the present invention (prepared by embodiment 1) in June, 2013, wedge shaped defect and abrasion place hyposensitiveness after March.
Claims (4)
1. the preparation method of Chinese medicine desensitization bamboo salt chewing gum, is characterized in that: comprise the following steps
(1) get 30～34 parts of sea salt dry powder, 30～32 parts of Concha Ostreae (calcined)s, 1～4 part of Rhizoma Drynariae, 30～32 parts of Indigo Naturaliss, 1～4 part of Radix Rehmanniae, mix, pulverize, obtain mixed powder, by weight;
Described sea salt dry powder prepares by the following method: gets sea salt, at 150 ℃～200 ℃, dries to moisture≤1%, pulverize, obtain sea salt dry powder, and for subsequent use;
(2) get bamboo section, to adding mixed powder in it, then seal with mud;
(3) the above-mentioned bamboo section with mud sealing is placed in to pottery, to the Colophonium that adds sea salt dry powder weight 5% in pottery, then carries out high-temperature calcination, 900～1100 ℃ of calcinings 20 hours, then bring up to temperature 1500 ℃ of calcinings 4 hours; After having calcined, naturally cool to room temperature, take out pottery, from bamboo section, take out the bamboo salt that has become crystal bulk, after pulverizing, obtain the bamboo salt that desensitizes;
(4) get Rhizoma Coptidis, add water to submerge, soak 10～20 hours, decoct 30min, filter to get filtrate and filtering residue, in filtering residue, add water again, decoct 30min, filter to get filtrate and filtering residue, filtering residue repeats to decoct once again, filters to get filtrate and filtering residue; Merge the filtrate of three times, be concentrated into 0.2g/ml(by crude drug amount), obtain Rhizoma Coptidis extract;
(5) desensitization bamboo salt is added in Rhizoma Coptidis extract, heating is dissolved it, centrifugal, gets supernatant; In supernatant, add sweeting agent neotame, heating is dissolved it, obtains chewing gum solvent;
(6) in 5g chewing gum solvent, add 5g gum base, 0.5g plasticizer, 1.2g emulsifying agent, 0.8g spice, makes chewing gum, obtains Chinese medicine desensitization bamboo salt chewing gum of the present invention.
2. the preparation method of Chinese medicine desensitization bamboo salt chewing gum according to claim 1, is characterized in that: in described step (5), the concentration of desensitization bamboo salt is 0.1g/ml, and the concentration of sweeting agent is 0.03g/ml.
3. the Chinese medicine desensitization bamboo salt chewing gum that utilizes the preparation method of the desensitization of the Chinese medicine described in any one bamboo salt chewing gum in claim 1～2 to prepare.
4. the application of the desensitization of the Chinese medicine described in claim 1～3 bamboo salt chewing gum in the food of preparation treatment dentine hypersensitivity.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105053493A (en) * | 2015-07-14 | 2015-11-18 | 界首市兆龙食品有限公司 | Tooth care chewing gum |
| CN115720954A (en) * | 2022-12-02 | 2023-03-03 | 刘晓军 | Chewing gum containing salt and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1080519A (en) * | 1990-12-28 | 1994-01-12 | 株式会社幸运 | Be used to promote the bamboo/salt composite that contains of oral hygiene |
| CN101019592A (en) * | 2006-12-19 | 2007-08-22 | 万金林 | Bamboo salt chewing gum and bubble gum |
| CN102342363A (en) * | 2011-09-23 | 2012-02-08 | 万金林 | Bamboo salt healthy tasty chewing gum |
-
2014
- 2014-01-24 CN CN201410036091.4A patent/CN103768438B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1080519A (en) * | 1990-12-28 | 1994-01-12 | 株式会社幸运 | Be used to promote the bamboo/salt composite that contains of oral hygiene |
| CN101019592A (en) * | 2006-12-19 | 2007-08-22 | 万金林 | Bamboo salt chewing gum and bubble gum |
| CN102342363A (en) * | 2011-09-23 | 2012-02-08 | 万金林 | Bamboo salt healthy tasty chewing gum |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105053493A (en) * | 2015-07-14 | 2015-11-18 | 界首市兆龙食品有限公司 | Tooth care chewing gum |
| CN115720954A (en) * | 2022-12-02 | 2023-03-03 | 刘晓军 | Chewing gum containing salt and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103768438B (en) | 2016-01-13 |
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