CN109480048A - A kind of dandelion chewing gum and preparation method thereof for treating canker sore - Google Patents

Abstract

The invention belongs to the technical field of functional health food, in particular to a dandelion chewing gum for treating oral ulcers, and further discloses a preparation method thereof. The chewing gum for treating oral ulcers of the present invention adds dandelion extract and other suitable traditional Chinese medicine extracts as natural pharmaceutical active ingredients, and can treat oral ulcers daily by chewing daily, which not only changes the traditional method for treating oral ulcers, but also So that patients no longer need to take medicine or spray medicine to the wound to treat oral ulcers; it is not only convenient to carry, but also more convenient for daily use.

Description

A kind of dandelion chewing gum for treating oral ulcer and preparation method thereof

technical field

The invention belongs to the technical field of functional health food, in particular to a dandelion chewing gum for treating oral ulcers, and further discloses a preparation method thereof.

Background technique

Oral ulcer, also known as "aphthous ulcer", is a very common oral mucosal disease, and it is the disease with the highest incidence among oral membrane diseases. The age of onset is generally between 10-30 years old. Among them, recurrent oral ulcers, also known as recurrent aphthous ulcers, among many oral diseases, in addition to dental caries and periodontal disease, are the most troublesome recurrent ulcers. It often repeatedly invades the non-keratinizing epithelium in the oral cavity, such as lip membrane, buccal membrane and tongue membrane, etc., causing trouble and inconvenience to patients in speaking, swallowing and eating.

At present, the treatment of recurrent oral ulcers lacks radical therapy, and there is no specific treatment plan, and domestic treatment plans are relatively inconsistent, but most of them advocate systemic combined with local, and traditional Chinese medicine combined with Western medicine. Topical therapy is the most common treatment for recurrent oral ulcers and is required in almost all patients. Topical treatment is based on the principles of anti-inflammatory, analgesic, infection control, and healing promotion. Common dosage forms of topical medication include gargles, powders, etc., but due to the flushing and dilution effect of saliva in the oral cavity, these dosage forms often cannot maintain an effective concentration locally on the ulcer surface. In conclusion, the existing topical drugs for the treatment of recurrent oral ulcers generally have problems such as inconvenient measures and poor treatment effects. Although traditional Chinese medicine treatment does have curative effect, it usually has a slow curative effect and a long course of treatment.

Dandelion is a perennial herb of the Compositae family, which is rich in protein, fat, carbohydrates, vitamins and trace elements, especially selenium, iron, calcium and other minerals needed by the human body. Dandelion has a wide range of pharmacological activities, especially the most significant antibacterial effect. Dandelion has a broad-spectrum bacteriostatic effect, especially for L-type streptococcus, Staphylococcus aureus, hemolytic streptococcus, and has a strong bactericidal effect on pneumococcus, meningococcus, diphtheria, Pseudomonas aeruginosa, Shigella , Salmonella typhi, etc. also have a certain bactericidal effect. Studies have shown that L-type streptococcus is a hemolytic streptococcus, which is transformed into a drug-resistant protoplast under the action of certain drugs. Recurrent oral ulcers occur. People have isolated and cultured L-type streptococcus from the lesions of recurrent oral ulcers, and found that its reproductive cycle is consistent with the recurrence cycle of oral ulcers; and injecting L-type streptococcus culture solution into animal mucosa can also cause oral cavity damage. ulcer. It can be seen that L-type streptococcus can cause delayed allergic reaction in the body. It has a common antigen with the oral mucosal epithelium, and can cause recurrent oral ulcers through cross-reaction. Therefore, dandelion has the potential to treat recurrent oral ulcers and is an ideal functional health care product for the treatment of recurrent oral ulcers.

Chewing gum is a kind of sugar that has become more popular in recent years, not only because chewing gum seems to be a trendy performance, but more because of the benefits of chewing this action to the human body. Chewing is good for oral health, stimulates saliva production, and promotes periodontal health. Therefore, the use of chewing gum as a carrier for the treatment of oral ulcers has become a feasible way, and it is expected that the treatment of oral ulcers can be achieved without taking medicine.

SUMMARY OF THE INVENTION

Therefore, the technical problem to be solved by the present invention is to provide a dandelion chewing gum for treating oral ulcer, and further disclose the preparation method thereof.

In order to solve the above-mentioned technical problems, the dandelion chewing gum for treating oral ulcers of the present invention comprises the following raw material components by weight: 0.1-50 parts by weight of dandelion extract, 0.1-20 parts by weight of traditional Chinese medicine extract, 1-50 parts by weight of chewing gum base, 0-30 parts by weight of sugar, 1-20 parts by weight of mint, 1-15 parts by weight of essence, and 0-20 parts by weight of polyol.

For the dandelion chewing gum for treating oral ulcers, the dandelion extract is prepared according to the following method: take dandelion, add 2-4 times by weight of 70-80% ethanol to soak, and perform reflux extraction for 2-4 times, each time Extract for 1-2 hours; collect the filtrate and concentrate it to extract, add water to make a suspension, adsorb it by macroporous resin D301, and elute with water; collect the eluate, decolorize and concentrate, and use 90-95 % ethanol is subjected to alcohol precipitation treatment, and the filter cake is filtered and vacuum-dried to obtain the desired dandelion extract.

The traditional Chinese medicine extracts include licorice extract, Bletilla striata extract and/or Angelica root extract.

The traditional Chinese medicine extract is obtained by extracting licorice, angelica and angelica with a mass ratio of 1-20:1-10:1-10.

The traditional Chinese medicine extract is prepared according to the following method: take licorice, Bletilla striata, and/or Angelica dahurica and add water to soak, and add 3-5 times of water of the total amount of raw materials to carry out high-fire boiling and simmering decoction, after cooling, concentrating, spray-drying, Obtain the desired traditional Chinese medicine extract.

The sugar is at least one of glucose, fructose, sucrose, maltose, lactose, syrup, oligosaccharide, and white sugar. Sucralose and white granulated sugar are preferred.

The polyol is at least one of xylitol, sorbitol, maltitol and lactitol. Xylitol is preferred.

The invention also discloses a method for preparing the dandelion chewing gum for treating oral ulcer, comprising the following steps:

(1) get selected amount of described chewing gum base heating and softening, for subsequent use;

(2) get selected amount of described dandelion extract, Chinese medicine extract, chewing gum base, sugar, mint, essence and polyhydric alcohol, mix at 60-80 ℃, obtain mixture;

(3) The obtained mixture is cooled, tableted and cut to obtain the required dandelion chewing gum.

The method for preparing the dandelion chewing gum for treating oral ulcers further includes the step of preparing the dandelion extract, specifically comprising: taking the dandelion and adding 2-4 times the weight of 70-80% ethanol to soak, and refluxing Extract 2-4 times, 1-2 hours each time; collect the filtrate and concentrate it to extract, add water to make a suspension, adsorb it by macroporous resin D301, and elute with water; collect the eluate and decolorize it After concentration, alcohol precipitation is carried out with 90-95% ethanol, and the filter cake is collected by filtration and vacuum-dried to obtain the desired dandelion extract.

The method for preparing the dandelion chewing gum for treating oral ulcers further includes the steps of preparing the Chinese medicine extract, which specifically includes: taking licorice, Bletilla striata, and/or Angelica dahurica and soaking in water, and adding 3-5 times the total amount of raw materials The obtained water is boiled with high heat and decocted with slow fire, and then cooled, concentrated and spray-dried to obtain the desired traditional Chinese medicine extract.

The chewing gum for treating oral ulcers of the present invention adds dandelion extract and other suitable traditional Chinese medicine extracts as natural pharmaceutical active ingredients, and can treat oral ulcers daily by chewing daily, which not only changes the traditional method for treating oral ulcers, but also So that patients no longer need to take medicine or spray medicine to the wound to treat oral ulcers; it is not only convenient to carry, but also more convenient for daily use.

The chewing gum for treating oral ulcers of the present invention, wherein the active ingredients of the medicine are selected from licorice extract, Bletilla striata extract and/or Angelica root extract. Among them, licorice has anti-inflammatory and anti-allergic effects, which help to protect the inflamed throat and tracheal mucosa; Baiji has the effects of astringent, hemostasis, swelling and muscle regeneration; Angelica has the effects of dispelling rheumatism, promoting blood circulation and expelling pus, promoting muscle and relieving pain. . The traditional Chinese medicine ingredients and dandelion have the effect of clearing away heat and detoxification, hemostasis, swelling and muscle regeneration, and have a good curative effect on the treatment of oral ulcers.

The chewing gum for treating oral ulcer has a scientific and reasonable formula, no toxic and side effects, natural green raw materials, easy to obtain, comfortable taste, simple and easy preparation process and low cost.

Detailed ways

Example 1

The dandelion chewing gum for treating oral ulcers described in this example, the preparation raw materials include: 0.1kg of dandelion extract, 0.5kg of traditional Chinese medicine extract, 50kg of chewing gum base, 10kg of sucralose, 20kg of mint, 15kg of essence, and 5kg of xylitol.

The dandelion extract described in this example is prepared according to the following method: take 1 kg of dandelion, add 3 kg of 75% ethanol to soak for 2 hours, and extract 3 times by reflux for 1.5 hours each time; collect the filtrate and concentrate it into extract, add water to make the extract A suspension was formed, adsorbed by macroporous resin D301, and eluted with water. The collected eluate was decolorized, concentrated, and subjected to alcohol precipitation with 95% ethanol by volume, placed in a refrigerator, filtered and the filter cake was taken. After vacuum drying, dandelion extract was obtained.

The traditional Chinese medicine extract described in this example is prepared according to the following method: 15 kg of licorice root, 5 kg of Bletilla striata, and 10 kg of Angelica dahurica are washed respectively, and soaked for 50 minutes; Add water 5 times the total amount of raw materials into the machine. After boiling and simmering for 50 minutes, the decocting liquid is cooled, concentrated and spray-dried to obtain the desired Chinese herbal medicine extract.

The dandelion chewing gum for the treatment of oral ulcer described in the present embodiment, its preparation method comprises the following steps:

(1) get the described chewing gum base of selected amount and heat to 70 ℃, make it soften, standby;

(2) get selected amount of described dandelion extract, Chinese medicine extract, chewing gum base, sucralose, mint, essence, polyol, heat to 70 ℃ and mix well, prepare mixture;

(3) The obtained mixture is cooled, tableted and cut to obtain dandelion chewing gum.

The dandelion chewing gum described in this example, adding dandelion extract and other traditional Chinese medicine composition extracts to the chewing gum as natural pharmaceutical active ingredients, can be used for the treatment of oral ulcers, which not only changes the traditional method of treating oral ulcers, but also enables patients to No more taking medicine or spraying the wound to treat mouth ulcers.

Example 2

The dandelion chewing gum for treating oral ulcers described in this example, the preparation raw materials include: 0.1kg of dandelion extract, 0.5kg of traditional Chinese medicine extract, 50kg of chewing gum base, 10kg of white sugar, 20kg of mint, 15kg of essence, and 5kg of maltitol.

The preparation method of the dandelion extract described in this example is the same as that in Example 1.

The preparation method of the traditional Chinese medicine extract described in this example is the same as that in Example 1.

The dandelion chewing gum for the treatment of oral ulcer described in the present embodiment, its preparation method comprises the following steps:

(1) get the described chewing gum base of selected amount and heat to 70 ℃, make it soften, standby;

(2) get selected amount of described dandelion extract, Chinese medicine extract, chewing gum base, sucralose, mint, essence, polyol, heat to 70 ℃ and mix well, prepare mixture;

(3) The obtained mixture is cooled, tableted and cut to obtain dandelion chewing gum.

The dandelion chewing gum described in this example, adding dandelion extract and other traditional Chinese medicine composition extracts to the chewing gum as natural pharmaceutical active ingredients, can be used for the treatment of oral ulcers, which not only changes the traditional method of treating oral ulcers, but also enables patients to No more taking medicine or spraying the wound to treat mouth ulcers.

Example 3

The dandelion chewing gum for the treatment of oral ulcers described in this example, the preparation raw materials include: 1kg of dandelion extract, 0.5kg of traditional Chinese medicine extract, 50kg of chewing gum base, 10kg of sucralose, 20kg of mint, 15kg of essence, and 5kg of sorbitol.

The preparation method of the dandelion extract described in this example is the same as that in Example 1.

The preparation method of the traditional Chinese medicine extract described in this example is the same as that in Example 1.

The dandelion chewing gum for the treatment of oral ulcer described in the present embodiment, its preparation method comprises the following steps:

(1) get the described chewing gum base of selected amount and heat to 70 ℃, make it soften, standby;

(2) get selected amount of described dandelion extract, Chinese medicine extract, chewing gum base, sucralose, mint, essence, polyol, heat to 70 ℃ and mix well, prepare mixture;

(3) The obtained mixture is cooled, tableted and cut to obtain dandelion chewing gum.

The dandelion chewing gum described in this example, adding dandelion extract and other traditional Chinese medicine composition extracts to the chewing gum as natural pharmaceutical active ingredients, can be used for the treatment of oral ulcers, which not only changes the traditional method of treating oral ulcers, but also enables patients to No more taking medicine or spraying the wound to treat mouth ulcers.

Example 4

The dandelion chewing gum for treating oral ulcers described in this example, the preparation raw materials include: 1kg of dandelion extract, 0.5kg of Chinese medicine extract, 50kg of chewing gum base, 10kg of white sugar, 20kg of mint, 15kg of essence, and 5kg of lactitol.

The preparation method of the dandelion extract described in this example is the same as that in Example 1.

The preparation method of the traditional Chinese medicine extract described in this example is the same as that in Example 1.

The dandelion chewing gum for the treatment of oral ulcer described in the present embodiment, its preparation method comprises the following steps:

(1) get the described chewing gum base of selected amount and heat to 70 ℃, make it soften, standby;

(2) get selected amount of described dandelion extract, Chinese medicine extract, chewing gum base, sucralose, mint, essence, polyol, heat to 70 ℃ and mix well, prepare mixture;

(3) The obtained mixture is cooled, tableted and cut to obtain dandelion chewing gum.

The dandelion chewing gum described in this example, adding dandelion extract and other traditional Chinese medicine composition extracts to the chewing gum as natural pharmaceutical active ingredients, can be used for the treatment of oral ulcers, which not only changes the traditional method of treating oral ulcers, but also enables patients to No more taking medicine or spraying the wound to treat mouth ulcers.

Example 5

The dandelion chewing gum for treating oral ulcers described in this example, the preparation raw materials include: 0.1kg of dandelion extract, 20kg of traditional Chinese medicine extract, 1kg of chewing gum base, 30kg of white sugar, 1kg of mint, and 15kg of essence.

The preparation method of the dandelion extract described in this example is the same as that in Example 1.

The traditional Chinese medicine extract described in this example is prepared according to the extraction method in Example 1, from licorice, Bletilla striata, and Angelica in a mass ratio of 1:10:1.

The preparation method of the dandelion chewing gum for treating oral ulcers described in this example is the same as that in Example 1.

The dandelion chewing gum described in this example, adding dandelion extract and other traditional Chinese medicine composition extracts to the chewing gum as natural pharmaceutical active ingredients, can be used for the treatment of oral ulcers, which not only changes the traditional method of treating oral ulcers, but also enables patients to No more taking medicine or spraying the wound to treat mouth ulcers.

Example 6

The dandelion chewing gum for treating oral ulcers described in this embodiment includes: 50kg of dandelion extract, 0.1kg of traditional Chinese medicine extract, 50kg of chewing gum base, 20kg of mint, 1kg of essence, and 20kg of xylitol.

The preparation method of the dandelion extract described in this example is the same as that in Example 1.

The traditional Chinese medicine extract described in this example is prepared from licorice, angelica, and angelica with a mass ratio of 20:1:10 according to the extraction method in Example 1.

The preparation method of the dandelion chewing gum for treating oral ulcers described in this example is the same as that in Example 1.

The dandelion chewing gum described in this example, adding dandelion extract and other traditional Chinese medicine composition extracts to the chewing gum as natural pharmaceutical active ingredients, can be used for the treatment of oral ulcers, which not only changes the traditional method of treating oral ulcers, but also enables patients to No more taking medicine or spraying the wound to treat mouth ulcers.

Experimental example

1. Clinical treatment

50 patients with oral ulcer were clinically observed and treated, including 25 males and 25 females, aged between 10 and 60 years old.

Using the dandelion chewing gum prepared in Example 1 of the present invention, chew it twice in the morning, noon and evening, one tablet each time, and chew it after meals, and the patient takes it for about 5 days.

According to the above treatment methods, 50 patients with oral ulcers were tracked and followed up, and the clinical treatment effects were recorded as follows: 47 cases (94%) were clinically cured, 1 case (2%) was markedly effective, 1 case (2%) was effective, and ineffective 1 case (2%), the total effective rate was 98%.

2. Typical cases:

Case 1

Zhang XX, male, 20 years old, a patient with oral ulcer; using the chewing gum of the present invention, after continuous use for 5 days, the oral ulcer was cured; no serious disease was found by follow-up for two months.

Case 2

Chen XX, female, 10 years old, a patient with oral ulcer; using the chewing gum of the present invention, after continuous use for 5 days, the oral ulcer was fully recovered; no serious disease was seen by follow-up visits for two months.

Case 3

XX, male, 40 years old, a patient with oral ulcer; using chewing gum of the present invention, after 5 days of continuous use, oral ulcer was fully recovered; no serious disease was seen by follow-up visits for two months.

Case 4

Wang XX, male, 35 years old, a patient with oral ulcer; using the chewing gum of the present invention, after 5 days of continuous use, the oral ulcer was fully recovered; no serious disease was seen by follow-up visits for two months.

Case 5

Yang XX, female, 50 years old, a patient with oral ulcer; using the chewing gum of the present invention, after continuous use for 5 days, the oral ulcer was fully recovered; no serious disease was seen by follow-up visits for two months.

Case 6

Fu XX, female, 60 years old, a patient with oral ulcer; using the chewing gum of the present invention, after 5 days of continuous use, the oral ulcer was fully recovered; no serious disease was seen by follow-up visits for two months.

Obviously, the above-mentioned embodiments are only examples for clear description, and are not intended to limit the implementation manner. For those of ordinary skill in the art, changes or modifications in other different forms can also be made on the basis of the above description. There is no need and cannot be exhaustive of all implementations here. And the obvious changes or changes derived from this are still within the protection scope of the present invention.

Claims (10)

1. a dandelion chewing gum for the treatment of oral ulcer, is characterized in that, described chewing gum comprises the raw material component of following weight portion: dandelion extract 0.1-50 weight portion, Chinese medicine extract 0.1-20 weight portion, chewing gum base 1- 50 parts by weight, 0-30 parts by weight of sugar, 1-20 parts by weight of mint, 1-15 parts by weight of essence, and 0-20 parts by weight of polyol. 2. the dandelion chewing gum for the treatment of oral ulcer according to claim 1, is characterized in that, described dandelion extract is obtained according to the following method: get dandelion and add 2-4 weight times of 70-80% ethanol to soak, and Perform reflux extraction for 2-4 times, each extraction for 1-2 hours; collect the filtrate and concentrate it to extract, add water to make a suspension, adsorb it by macroporous resin D301, and elute with water; collect the eluate After decolorization, the mixture is concentrated, and subjected to alcohol precipitation treatment with 90-95% ethanol, and the filter cake is collected by filtration and vacuum-dried to obtain the desired dandelion extract. 3. The dandelion chewing gum for the treatment of oral ulcers according to claim 1 or 2, wherein the traditional Chinese medicine extract comprises licorice extract, Bletilla striata extract and/or Angelica root extract. 4. The dandelion chewing gum for the treatment of oral ulcer according to claim 3, characterized in that, the Chinese medicine extract is obtained by extracting licorice, Bletilla striata and Angelica Radix with a mass ratio of 1-20:1-10:1-10. 5. the dandelion chewing gum for the treatment of oral ulcer according to claim 3 or 4, is characterized in that, described Chinese medicine extract is obtained according to the following method: get licorice, Bletilla striata, and/or Angelica dahurica and add water to soak, and add raw material total amount 3-5 times of water is boiled with high fire and decocted with slow fire, cooled, concentrated and spray-dried to obtain the desired traditional Chinese medicine extract. 6. The dandelion chewing gum for treating oral ulcers according to any one of claims 1-5, wherein the sugar is at least one selected from the group consisting of glucose, fructose, sucrose, maltose, lactose, syrup, oligosaccharide and white granulated sugar. A sort of. 7. The dandelion chewing gum for treating oral ulcers according to any one of claims 1-5, wherein the polyol is at least one of xylitol, sorbitol, maltitol, and lactitol. 8. a method of preparing the dandelion chewing gum for the treatment of oral ulcer described in any one of claims 1-7, is characterized in that, comprises the steps: (1) get selected amount of described chewing gum base heating and softening, for subsequent use; (2) get selected amount of described dandelion extract, Chinese medicine extract, chewing gum base, sugar, mint, essence and polyhydric alcohol, mix at 60-80 ℃, obtain mixture; (3) The obtained mixture is cooled, tableted and cut to obtain the required dandelion chewing gum. 9. The method for preparing the dandelion chewing gum for the treatment of oral ulcers according to claim 8, further comprising the step of preparing the dandelion extract, specifically comprising: taking dandelion and adding 70% of 2-4 weight times. - Soak in 80% ethanol, and perform reflux extraction for 2-4 times, each extraction for 1-2 hours; collect the filtrate and concentrate it to extract, and add water to make a suspension, which is adsorbed by macroporous resin D301 and extracted with water. Elution is carried out; the eluate is collected, decolorized, concentrated, and subjected to alcohol precipitation treatment with 90-95% ethanol, and the filter cake is filtered and dried under vacuum to obtain the desired dandelion extract. 10. the method for preparing the dandelion chewing gum for the treatment of oral ulcer according to claim 8 or 9, is characterized in that, also comprises the step of preparing described Chinese medicine extract, specifically comprises: taking licorice, Bletilla striata, and/or Angelica dahurica Add water to soak, and add water 3-5 times the total amount of raw materials to carry out high-fire boiling and slow-fire decocting, cooling, concentrating and spray drying to obtain the desired traditional Chinese medicine extract.