CN109480048A - A kind of dandelion chewing gum and preparation method thereof for treating canker sore - Google Patents
A kind of dandelion chewing gum and preparation method thereof for treating canker sore Download PDFInfo
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- CN109480048A CN109480048A CN201811474495.6A CN201811474495A CN109480048A CN 109480048 A CN109480048 A CN 109480048A CN 201811474495 A CN201811474495 A CN 201811474495A CN 109480048 A CN109480048 A CN 109480048A
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- Prior art keywords
- dandelion
- chewing gum
- extract
- canker sore
- treatment
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- 229940112822 chewing gum Drugs 0.000 title claims abstract description 80
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 80
- 208000020670 canker sore Diseases 0.000 title claims abstract description 75
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 title claims abstract description 63
- 241000245665 Taraxacum Species 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 60
- 239000003814 drug Substances 0.000 claims abstract description 32
- 229940067866 dandelion extract Drugs 0.000 claims abstract description 29
- 235000020691 dandelion extract Nutrition 0.000 claims abstract description 29
- 239000001845 taraxacum officinale leaf extract Substances 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 18
- 235000019441 ethanol Nutrition 0.000 claims description 17
- 244000246386 Mentha pulegium Species 0.000 claims description 14
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 14
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 14
- 235000001050 hortel pimenta Nutrition 0.000 claims description 14
- 241001313857 Bletilla striata Species 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 11
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 10
- 235000000346 sugar Nutrition 0.000 claims description 8
- 150000005846 sugar alcohols Polymers 0.000 claims description 8
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 7
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 235000021552 granulated sugar Nutrition 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 5
- 239000012065 filter cake Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
- 235000010447 xylitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
- 229960002675 xylitol Drugs 0.000 claims description 5
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 4
- 235000011477 liquorice Nutrition 0.000 claims description 4
- 241000213006 Angelica dahurica Species 0.000 claims description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 3
- 239000000832 lactitol Substances 0.000 claims description 3
- 235000010448 lactitol Nutrition 0.000 claims description 3
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 3
- 229960003451 lactitol Drugs 0.000 claims description 3
- 229940010454 licorice Drugs 0.000 claims description 3
- 239000000845 maltitol Substances 0.000 claims description 3
- 235000010449 maltitol Nutrition 0.000 claims description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 3
- 229940035436 maltitol Drugs 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229920001542 oligosaccharide Polymers 0.000 claims description 2
- 150000002482 oligosaccharides Chemical class 0.000 claims description 2
- -1 sorbierite Chemical compound 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 claims 3
- ZTVIKZXZYLEVOL-DGKWVBSXSA-N 2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester Chemical group C([C@H]1CC[C@@H](C2)N1C)C2OC(=O)C(O)C1=CC=CC=C1 ZTVIKZXZYLEVOL-DGKWVBSXSA-N 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract description 8
- 238000005507 spraying Methods 0.000 abstract description 8
- 230000001055 chewing effect Effects 0.000 abstract description 5
- 230000006978 adaptation Effects 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 12
- 240000001949 Taraxacum officinale Species 0.000 description 9
- 230000000306 recurrent effect Effects 0.000 description 9
- 241000194017 Streptococcus Species 0.000 description 8
- 241000125175 Angelica Species 0.000 description 7
- 206010028034 Mouth ulceration Diseases 0.000 description 7
- 239000004376 Sucralose Substances 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 235000019408 sucralose Nutrition 0.000 description 7
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000001114 myogenic effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000461895 Keratosa Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002804 anti-anaphylactic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
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- 230000003694 hair properties Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000036445 liquid secretion Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 208000018962 mouth sore Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940037201 oris Drugs 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 201000006727 periodontosis Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Confectionery (AREA)
Abstract
The invention belongs to functional health-care food technical fields, and in particular to a kind of dandelion chewing gum for treating canker sore, and preparation method is further disclosed.The chewing gum for the treatment of canker sore of the present invention, dandelion extract and other adaptation Chinese medical extracts are added as natural active pharmaceutical ingredient, it can daily treatment canker sore by daily chewing, the method for not only changing traditional treatment canker sore can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound；It is not only convenient for carrying and routine use is more convenient.
Description
Technical field
The invention belongs to functional health-care food technical fields, and in particular to a kind of dandelion for treating canker sore mouthful is fragrant
Sugar, and preparation method is further disclosed.
Background technique
Canker sore, also known as " aphtha " are a kind of very common diseases of cari oris mucosa, are sent out in the film disease of oral cavity
A kind of sick highest disease of rate, age of onset is generally between 10-30 years old.Wherein, recurrent oral ulceration, also referred to as recurrent mouth
Sore other than saprodontia and periodontosis, just belongs to recurrent ulcer and most makes us perplexing in many diseases in oral cavity.It is often repeatedly invaded
Violate non-keratosa epithelium, such as lip film, cheek film and tongue film etc. in oral cavity, cause patient to speak, swallow on diet
Puzzlement and inconvenient.
Currently, the treatment for recurrent oral ulceration lacks radical treatment, there is no specific treatment scheme, and the country controls yet
Treatment scheme is compared with disunity, but most opinion whole bodies combine the treatment method of part and Enema compress doctor trained in Western medicine.Local treatment is multiple
The hair property most common treatment method of canker sore, nearly all patient require to use.Local treatment is with anti-inflammatory, analgesic, control
Infection promotes healing to be principle.Local application's common dosage forms have gargle, powder etc., but due in oral cavity saliva wash away
Diluting effect makes these dosage forms tend not to locally keep effective concentration in ulcer surface.In short, existing local application is to recurrence
Property canker sore the generally existing measure for the treatment of is inconvenient, the problems such as therapeutic effect is bad.Though traditional Chinese medical herbal treatment truly has curative effect,
Usual slow curative effect, the course for the treatment of are longer.
Dandelion is composite family herbaceos perennial, protein rich in, fat, carbohydrate, Duo Zhongwei
Raw element and microelement, the minerals of the needed by human body such as selenium especially rich in, iron, calcium.Dandelion has extensive pharmacology
Activity, especially antibacterial action are the most significant.Dandelion has broad-spectrum antibacterial effect, especially to L-type streptococcus, golden yellow Portugal
Grape coccus, hemolytic streptococcus have stronger bactericidal effect, to Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, green pus bar
Bacterium, shigella dysenteriae, typhoid bacillus etc. also have certain biocidal efficacies.Studies have shown that L-type streptococcus is hemolytic streptococcus, at certain
The protoplast with drug resistance being transformed under a little drug effects, it usually hides in the cell, becomes when condition is suitable for
Hemolytic streptococcus, and lead to recurrent oral ulceration.People have separated training from recurrent oral ulceration lesion
L-type streptococcus has been raised, and has found that its breeding cycle is consistent with the recurrence period of canker sore；And L-type streptococcus is trained
Canker sore can also be caused under nutrient solution injection mucous membrane of animal.As it can be seen that L-type streptococcus can cause body Tardive allergy, it
There are common antigens with Oral mucosa keratinocyte, cause recurrent oral ulceration by cross reaction.Therefore, dandelion has
The effect of potential treatment recurrent oral ulceration, is the ideal functional health product for treating recurrent oral ulceration.
Chewing gum is a kind of sugar relatively popular in recent years, not just merely because chew gum seems a kind of trend
The performance being cool is more because chewing this movement to the benefit of human body.Chewing is beneficial to oral health, can stimulate saliva
Liquid secretion has and is easy to periodontal health.Therefore, a kind of feasible side is become using the treatment that chewing gum carries out canker sore as carrier
Formula is contemplated for realizing the treatment of canker sore by way of without medication.
Summary of the invention
For this purpose, technical problem to be solved by the present invention lies in a kind of dandelion chewing gum for treating canker sore is provided,
And preparation method is further disclosed.
In order to solve the above technical problems, a kind of dandelion chewing gum for treating canker sore of the present invention, the mouth
Fragrant sugar includes the raw material components of following parts by weight: dandelion extract 0.1-50 parts by weight, Chinese medical extract 0.1-20 parts by weight,
Chewing gum base 1-50 parts by weight, sugar 0-30 parts by weight, peppermint 1-20 parts by weight, essence 1-15 parts by weight, polyalcohol 0-20 weight
Measure part.
The dandelion chewing gum of the treatment canker sore, the dandelion extract are made as follows: taking
The ethyl alcohol that the 70-80% of 2-4 times of weight amount is added in dandelion impregnates, and carries out refluxing extraction 2-4 times, extracts 1-2 hours every time；
It collects filtrate and is concentrated into medicinal extract, and water is added to make that suspension is made, adsorbed through macroreticular resin D301, and eluted with water；It collects
Eluent is concentrated after decolourizing, and carries out alcohol precipitation processing with the ethyl alcohol of 90-95%, and it is vacuum dried to filter to take filter cake, obtains institute
Need dandelion extract.
The Chinese medical extract includes licorice, bletilla striata extract and/or Angelica Dahurica extract.
The Chinese medical extract be 1-20:1-10:1-10 by mass ratio Radix Glycyrrhizae, the bletilla striata, the root of Dahurain angelica extract to obtain.
The Chinese medical extract is made as follows: extracting liquorice, the bletilla striata, and/or the root of Dahurain angelica are soaked in water, and original is added
The water of 3-5 times of total amount of material is boiled by intense fire and is cooked by slow fire, and through cooling, concentration, spray drying, obtains required traditional Chinese medicine extraction
Object.
The sugar is at least one of glucose, fructose, sucrose, maltose, lactose, syrup, oligosaccharide, white granulated sugar.
It is preferred that Sucralose, white granulated sugar.
The polyalcohol is at least one of xylitol, sorbierite, maltitol, lactitol.It is preferred that xylitol.
The invention also discloses a kind of methods of dandelion chewing gum for preparing the treatment canker sore, including walk as follows
It is rapid:
(1) a selected amount of chewing gum base is taken to heat and soften, it is spare；
(2) a selected amount of dandelion extract, Chinese medical extract, chewing gum base, sugar, peppermint, essence and more are taken
First alcohol mixes in 60-80 DEG C, obtains mixture；
(3) by the obtained mixture through cooling, tabletting, cutting to get required dandelion chewing gum.
The method of the dandelion chewing gum for preparing the treatment canker sore, further includes preparing the dandelion to mention
The step of taking object specifically includes: the ethyl alcohol for taking dandelion that the 70-80% of 2-4 times of weight amount is added impregnates, and carries out refluxing extraction
It 2-4 times, extracts 1-2 hours every time；It collects filtrate and is concentrated into medicinal extract, and water is added to make that suspension is made, inhaled through macroreticular resin D301
It is attached, and eluted with water；It collects eluent to be concentrated after decolourizing, and alcohol precipitation processing is carried out with the ethyl alcohol of 90-95%, filter to take
Filter cake is vacuum dried, obtains required dandelion extract.
The method of the dandelion chewing gum for preparing the treatment canker sore, further includes preparing the traditional Chinese medicine extraction
The step of object specifically includes: extracting liquorice, the bletilla striata, and/or the root of Dahurain angelica are soaked in water, and the water that 3-5 times of raw material total amount is added carries out force
Fire is boiled and is cooked by slow fire, and through cooling, concentration, spray drying, obtains required Chinese medical extract.
The chewing gum for the treatment of canker sore of the present invention adds dandelion extract and other adaptation Chinese medical extracts
As natural active pharmaceutical ingredient, by daily chewing can daily treatment canker sore, not only change traditional treatment mouth
The method of chamber ulcer can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound；No
It is only convenient for carrying and routine use is more convenient.
The chewing gum for the treatment of canker sore of the present invention, active ingredient of Chinese herbs chooses licorice, the bletilla striata is extracted
Object and/or Angelica Dahurica extract.Wherein, Radix Glycyrrhizae has anti-inflammatory, antianaphylactic effect, facilitates the throat for protecting inflammation and tracheae is viscous
Film；The bletilla striata has the effect of astringing to arrest bleeding, detumescence and promoting granulation；The root of Dahurain angelica then has the effect of wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving.
The effect of traditional Chinese medicine ingredients and dandelion play its effect altogether, play its clearing heat and detoxicating, hemostasis, detumescence, myogenic, to canker sore
Treatment tool has a better effect.
The chewing gum for the treatment of canker sore of the present invention, formula is scientific and reasonable, has no toxic side effect, each raw material natural green
Color and easy, comfortable taste of drawing materials, and preparation is simple, cost is relatively low.
Specific embodiment
Embodiment 1
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparing raw material includes: dandelion extract
0.1kg, Chinese medical extract 0.5kg, chewing gum base 50kg, Sucralose 10kg, peppermint 20kg, essence 15kg, xylitol
5kg。
Dandelion extract described in the present embodiment is prepared as follows: taking dandelion 1kg, 3kg volumetric concentration is added
75% ethyl alcohol impregnates 2 hours, refluxing extraction 3 times, every time 1.5 hours；It collects filtrate and is condensed into medicinal extract, water is added to make medicinal extract at mixed
Suspension is adsorbed through macroreticular resin D301, and is eluted with water, is collected eluent and is concentrated after decolourizing, with volumetric concentration 95%
Ethyl alcohol carry out alcohol precipitation processing, be placed in refrigerator placement, filter and take filter cake vacuum dried, obtain dandelion extract.
Chinese medical extract described in the present embodiment is prepared as follows: by Radix Glycyrrhizae 15kg, bletilla striata 5kg and root of Dahurain angelica 10kg,
It cleans and impregnates 50 minutes respectively；Chinese medicine material after immersion is put into sealing boiling machine, it is total that raw material is added in boiling machine
The water of 5 times of amount, after being boiled and being cooked by slow fire by intense fire 50 minutes, decoction liquor obtains in required through cooling, concentration, spray drying
Medicament extract.
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparation method includes the following steps:
(1) it takes a selected amount of chewing gum base to be heated to 70 DEG C, makes its softening, it is spare；
(2) a selected amount of dandelion extract, Chinese medical extract, chewing gum base, Sucralose, peppermint, perfume (or spice) are taken
Essence, polyalcohol are heated to 70 DEG C and are sufficiently mixed uniformly, mixture is prepared；
(3) by the obtained mixture through cooling, tabletting, cutting to get dandelion chewing gum.
Dandelion chewing gum described in the present embodiment adds the extract and other Chinese medicine composition of dandelion in chewing gum
Extract can be used for treating canker sore as natural active pharmaceutical ingredient, not only change traditional treatment canker sore
Method can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound.
Embodiment 2
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparing raw material includes: dandelion extract
0.1kg, Chinese medical extract 0.5kg, chewing gum base 50kg, white granulated sugar 10kg, peppermint 20kg, essence 15kg, maltitol
5kg。
The preparation method of dandelion extract described in the present embodiment is same as Example 1.
The preparation method of Chinese medical extract described in the present embodiment is same as Example 1.
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparation method includes the following steps:
(1) it takes a selected amount of chewing gum base to be heated to 70 DEG C, makes its softening, it is spare；
(2) a selected amount of dandelion extract, Chinese medical extract, chewing gum base, Sucralose, peppermint, perfume (or spice) are taken
Essence, polyalcohol are heated to 70 DEG C and are sufficiently mixed uniformly, mixture is prepared；
(3) by the obtained mixture through cooling, tabletting, cutting to get dandelion chewing gum.
Dandelion chewing gum described in the present embodiment adds the extract and other Chinese medicine composition of dandelion in chewing gum
Extract can be used for treating canker sore as natural active pharmaceutical ingredient, not only change traditional treatment canker sore
Method can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound.
Embodiment 3
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparing raw material includes: dandelion extract
1kg, Chinese medical extract 0.5kg, chewing gum base 50kg, Sucralose 10kg, peppermint 20kg, essence 15kg, D-sorbite
5kg。
The preparation method of dandelion extract described in the present embodiment is same as Example 1.
The preparation method of Chinese medical extract described in the present embodiment is same as Example 1.
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparation method includes the following steps:
(1) it takes a selected amount of chewing gum base to be heated to 70 DEG C, makes its softening, it is spare；
(2) a selected amount of dandelion extract, Chinese medical extract, chewing gum base, Sucralose, peppermint, perfume (or spice) are taken
Essence, polyalcohol are heated to 70 DEG C and are sufficiently mixed uniformly, mixture is prepared；
(3) by the obtained mixture through cooling, tabletting, cutting to get dandelion chewing gum.
Dandelion chewing gum described in the present embodiment adds the extract and other Chinese medicine composition of dandelion in chewing gum
Extract can be used for treating canker sore as natural active pharmaceutical ingredient, not only change traditional treatment canker sore
Method can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound.
Embodiment 4
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparing raw material includes: dandelion extract
1kg, Chinese medical extract 0.5kg, chewing gum base 50kg, white granulated sugar 10kg, peppermint 20kg, essence 15kg, lactitol 5kg.
The preparation method of dandelion extract described in the present embodiment is same as Example 1.
The preparation method of Chinese medical extract described in the present embodiment is same as Example 1.
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparation method includes the following steps:
(1) it takes a selected amount of chewing gum base to be heated to 70 DEG C, makes its softening, it is spare；
(2) a selected amount of dandelion extract, Chinese medical extract, chewing gum base, Sucralose, peppermint, perfume (or spice) are taken
Essence, polyalcohol are heated to 70 DEG C and are sufficiently mixed uniformly, mixture is prepared；
(3) by the obtained mixture through cooling, tabletting, cutting to get dandelion chewing gum.
Dandelion chewing gum described in the present embodiment adds the extract and other Chinese medicine composition of dandelion in chewing gum
Extract can be used for treating canker sore as natural active pharmaceutical ingredient, not only change traditional treatment canker sore
Method can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound.
Embodiment 5
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparing raw material includes: dandelion extract
0.1kg, Chinese medical extract 20kg, chewing gum base 1kg, white granulated sugar 30kg, peppermint 1kg, essence 15kg.
The preparation method of dandelion extract described in the present embodiment is same as Example 1.
Chinese medical extract described in the present embodiment be by mass ratio be by mass ratio be 1:10:1 Radix Glycyrrhizae, the bletilla striata, the root of Dahurain angelica, press
It is prepared according to extracting method in embodiment 1.
The preparation method is the same as that of Example 1 for the dandelion chewing gum for the treatment of canker sore described in the present embodiment.
Dandelion chewing gum described in the present embodiment adds the extract and other Chinese medicine composition of dandelion in chewing gum
Extract can be used for treating canker sore as natural active pharmaceutical ingredient, not only change traditional treatment canker sore
Method can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound.
Embodiment 6
The dandelion chewing gum of canker sore is treated described in the present embodiment, preparing raw material includes: dandelion extract
50kg, Chinese medical extract 0.1kg, chewing gum base 50kg, peppermint 20kg, essence 1kg, xylitol 20kg.
The preparation method of dandelion extract described in the present embodiment is same as Example 1.
Chinese medical extract described in the present embodiment be by mass ratio be by mass ratio be 20:1:10 Radix Glycyrrhizae, the bletilla striata, the root of Dahurain angelica,
It is prepared according to extracting method in embodiment 1.
The preparation method is the same as that of Example 1 for the dandelion chewing gum for the treatment of canker sore described in the present embodiment.
Dandelion chewing gum described in the present embodiment adds the extract and other Chinese medicine composition of dandelion in chewing gum
Extract can be used for treating canker sore as natural active pharmaceutical ingredient, not only change traditional treatment canker sore
Method can also make patient no longer need to carry out treatment canker sore by taking medicine or spraying medicament toward wound.
Experimental example
1, clinical treatment
Clinical observation treatment is carried out to 50 canker sore patients, wherein male 25, female 25, the age was at 10-60 years old
Between.
Using the dandelion chewing gum prepared in the embodiment of the present invention 1, each chewing 2 times in the morning, afternoon and evening, each one, after meal
It chews, patient takes 5 days or so.
Therapeutic effect tracking and follow-up, record clinical treatment effect are carried out to 50 canker sore patients according to above-mentioned treatment method
Fruit is as follows: clinic reaches patient 47 (94%) of recovery from illness, effective 1 (2%), effective 1 (2%), invalid 1 (2%), always has
Efficiency is 98%.
2, typical case:
Case 1
XX is opened, it is male, 20 years old, canker sore patient；Using chewing gum of the invention, after continuous use 5 days, canker sore is fullyed recover from an illness
More；It has no within follow-up two months and suffers from again.
Case 2
Old XX, female, 10 years old, canker sore patient；Using chewing gum of the invention, after continuous use 5 days, canker sore is fullyed recover from an illness
More；It has no within follow-up two months and suffers from again.
Case 3
XX is given as security, it is male, 40 years old, canker sore patient；Using chewing gum of the invention, after continuous use 5 days, canker sore is fullyed recover from an illness
More；It has no within follow-up two months and suffers from again.
Case 4
King XX, male, 35 years old, canker sore patient；Using chewing gum of the invention, after continuous use 5 days, canker sore is fullyed recover from an illness
More；It has no within follow-up two months and suffers from again.
Case 5
Poplar XX, female, 50 years old, canker sore patient；Using chewing gum of the invention, after continuous use 5 days, canker sore is fullyed recover from an illness
More；It has no within follow-up two months and suffers from again.
Case 6
Pay XX, female, 60 years old, canker sore patient；Using chewing gum of the invention, after continuous use 5 days, canker sore is fullyed recover from an illness
More；It has no within follow-up two months and suffers from again.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (10)
1. a kind of dandelion chewing gum for treating canker sore, which is characterized in that the chewing gum includes the original of following parts by weight
Expect component: dandelion extract 0.1-50 parts by weight, Chinese medical extract 0.1-20 parts by weight, chewing gum base 1-50 parts by weight,
Sugared 0-30 parts by weight, peppermint 1-20 parts by weight, essence 1-15 parts by weight, polyalcohol 0-20 parts by weight.
2. the dandelion chewing gum for the treatment of canker sore according to claim 1, which is characterized in that the dandelion is extracted
Object is made as follows: the ethyl alcohol for taking dandelion that the 70-80% of 2-4 times of weight amount is added impregnates, and carries out refluxing extraction
It 2-4 times, extracts 1-2 hours every time；It collects filtrate and is concentrated into medicinal extract, and water is added to make that suspension is made, inhaled through macroreticular resin D301
It is attached, and eluted with water；It collects eluent to be concentrated after decolourizing, and alcohol precipitation processing is carried out with the ethyl alcohol of 90-95%, filter to take
Filter cake is vacuum dried, obtains required dandelion extract.
3. the dandelion chewing gum for the treatment of canker sore according to claim 1 or 2, which is characterized in that the Chinese medicine mentions
Taking object includes licorice, bletilla striata extract and/or Angelica Dahurica extract.
4. the dandelion chewing gum for the treatment of canker sore according to claim 3, which is characterized in that the Chinese medical extract
For be 1-20:1-10:1-10 by mass ratio Radix Glycyrrhizae, the bletilla striata, the root of Dahurain angelica extract to obtain.
5. the dandelion chewing gum for the treatment of canker sore according to claim 3 or 4, which is characterized in that the Chinese medicine mentions
Take object to be made as follows: extracting liquorice, the bletilla striata, and/or the root of Dahurain angelica are soaked in water, and be added the water of 3-5 times of raw material total amount into
Row is boiled by intense fire and is cooked by slow fire, and through cooling, concentration, spray drying, obtains required Chinese medical extract.
6. the dandelion chewing gum for the treatment of canker sore according to claim 1-5, which is characterized in that the sugar
For at least one of glucose, fructose, sucrose, maltose, lactose, syrup, oligosaccharide, white granulated sugar.
7. the dandelion chewing gum for the treatment of canker sore according to claim 1-5, which is characterized in that described more
First alcohol is at least one of xylitol, sorbierite, maltitol, lactitol.
8. a kind of method for the dandelion chewing gum for preparing any one of claim 1-7 treatment canker sore, feature exist
In including the following steps:
(1) a selected amount of chewing gum base is taken to heat and soften, it is spare；
(2) a selected amount of dandelion extract, Chinese medical extract, chewing gum base, sugar, peppermint, essence and polyalcohol are taken,
It is mixed in 60-80 DEG C, obtains mixture；
(3) by the obtained mixture through cooling, tabletting, cutting to get required dandelion chewing gum.
9. the method for the dandelion chewing gum according to claim 8 for preparing the treatment canker sore, which is characterized in that
Further include the steps that preparing the dandelion extract, specifically include: dandelion being taken to be added the 70-80%'s of 2-4 times of weight amount
Ethyl alcohol impregnates, and carries out refluxing extraction 2-4 times, extracts 1-2 hours every time；It collects filtrate and is concentrated into medicinal extract, and water is added to make to be made
Suspension is adsorbed through macroreticular resin D301, and is eluted with water；It collects eluent to be concentrated after decolourizing, and with 90-95%'s
Ethyl alcohol carries out alcohol precipitation processing, and it is vacuum dried to filter to take filter cake, obtains required dandelion extract.
10. the method for the dandelion chewing gum for preparing the treatment canker sore according to claim 8 or claim 9, feature
It is, further include the steps that preparing the Chinese medical extract, specifically include: extracting liquorice, the bletilla striata, and/or the root of Dahurain angelica are soaked in water, and
The water that 3-5 times of raw material total amount is added is boiled by intense fire and is cooked by slow fire, and through cooling, concentration, spray drying, obtains required Chinese medicine
Extract.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113662926A (en) * | 2021-08-23 | 2021-11-19 | 上海六普医疗科技有限公司 | TPU (thermoplastic polyurethane) oral elastic membrane and preparation method thereof |
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| KR20180068697A (en) * | 2016-12-14 | 2018-06-22 | 윤셍 종 | Mouthwash containing green tea |
| CN108671212A (en) * | 2018-07-03 | 2018-10-19 | 温州医科大学 | A kind of chewing gum lozenge and preparation method thereof for treating canker sore |
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| CN102028825A (en) * | 2010-11-19 | 2011-04-27 | 天津太平洋制药有限公司 | Dental ulcer tablet containing dandelion and preparation method thereof |
| KR20180068697A (en) * | 2016-12-14 | 2018-06-22 | 윤셍 종 | Mouthwash containing green tea |
| CN106728859A (en) * | 2016-12-15 | 2017-05-31 | 青岛海澄知识产权事务有限公司 | A kind of method for preparing chewing gum for treating canker sore |
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