CN102028825A - Dental ulcer tablet containing dandelion and preparation method thereof - Google Patents
Dental ulcer tablet containing dandelion and preparation method thereof Download PDFInfo
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- CN102028825A CN102028825A CN2010105524804A CN201010552480A CN102028825A CN 102028825 A CN102028825 A CN 102028825A CN 2010105524804 A CN2010105524804 A CN 2010105524804A CN 201010552480 A CN201010552480 A CN 201010552480A CN 102028825 A CN102028825 A CN 102028825A
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Abstract
The invention relates to a dental ulcer tablet containing dandelion, comprising a medicated adhering layer and a water-insoluble protective layer, wherein the medicated adhering layer comprises 0.1-15mg of extracts containing the dandelion, carbopol, borneol, low substituted hydroxypropy cellulose and sodium carboxymethylcellulose; the water-insoluble protective layer consists of ethyl cellulose and edible pigment; the extracts containing the dandelion consist of 8-10 grams of mint, 15-20 grams of dandelion, 5-10 grams of rush, and 10-15 grams of evodia rutaecarpa. The tablet medicament provided by the invention can fully improve local ulcer tissues and heal soon in order to attain the purpose of therapy. The Chinese patent medicine is innoxious and harmless to human bodies, and is convenient to take without decoction. The tablet seeks both temporary solution and permanent cure, and has significant clinical effects with effective rate of 98%.
Description
Technical field
The present invention relates to treat the medicine of oral disease, particularly relate to a kind of mouth ulcer paster that contains Herba Taraxaci and preparation method thereof.
Technical background
Recurrent oral ulceration also claims recurrent aphtha, in the many diseases in oral cavity, except dental caries and periodontal disease, just belongs to recurrent ulcer and makes us puzzlement most.It is often invaded in the oral cavity repeatedly, the epithelium of non-keratinization, for example lip mucosa, cheek mucosa and lingual mucous membrane etc., cause the patient speak, swallow with diet on puzzlement and inconvenience.The oral mucosa disease is a kind of commonly encountered diseases, frequently-occurring disease clinically.Due to illness feelings complexity, symptom are different, the easy mistaken diagnosis of patient.The common method majority is an anti symptom treatment clinically at present, promptly adopts anti-inflammatory analgetic, control disease multiselect methods such as hormone (as meticorten, dexamethasone) and immunosuppressant cellulose dissolution.But its therapeutic effect is unsatisfactory, and side effect is bigger, and the relapse rate height often makes patient lose the confidence of treatment, disease is no longer reported the hope of rehabilitation.Chinese medicine expert thinks, the disease of cari oris mucosa is many because of internal injury caused by excess of seven emotions, plain body weakness, the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, cause hot and suffocating, hyperactivity of deficient fire stifling and send out.For capturing this persistent ailment, national famous expert's establishment " traditional Chinese medical science oral mucosa disease is ground and controlled expert group " is invited in the hospital of traditional Chinese hospital, Deshengmen, Beijing, lead down the famous Prof Lee of China, director Zang, the cause of disease, pathology at the disease of cari oris mucosa, study intensively with great concentration, tackling key problem hand in hand, their break the normal procedure once more medical science final conclusion, absorb the Chinese Pharmacopoeia elite, constantly carried out extensive and deep investigation with domestic traditional Chinese medical science educational circles, a large amount of clinical practices are finished in accumulation, are the Therapeutic Principle with removing the necrotic tissue and promoting granulation, yin nourishing detoxicating, function of spleen and stomach regulating, strengthening vital QI to eliminate pathogenic factors.Created " immunologic balance therapy "., successfully developed the serial oral mucosa disease specially good effect prescription that integrates antiviral, infection, raising immunologic function triple role, treatment (oral ulcer, behcets disease, lichen planus, chronic cheilitis, bright mouth, dry syndrome etc.) oral mucosa chronic disease has been had significant curative effect.Once use, both can make examples up to ten thousand suffer the oral disease patient of ailing puzzlement to obtain rehabilitation for a long time at short notice, the various places patient comes institute to seek medical advice one after another.
Clinical trial certificate: this therapy for treating recurrent oral ulceration, behcets disease and lichen planus, generally effectively treat according to patient's course of disease length, ill degree and health.This therapy is based on the traditional Chinese medical science, special bag is outstanding, pass through secular clinical observation and discover, the have its source in category of " wetting " " heat " " poison " of morbidity, think that pathogenesis is to accumulate in heart spleen volt fire, dysfunction of the spleen in transportation, the noxious dampness, due to the deficiency of both the heart and spleen, stagnation of blood stasis, the not good fire of water, flaming up of heart-fire, proposed dampness detoxifcation, blood circulation promoting and blood stasis dispelling, warming and recuperating the spleen and kidney and treated new therapy.Because of reaction and the difference of patient,,,, can make the order of severity of effective disease controlling and shorten the course of disease time promptly with administration if can send out in early days in disease so should find out indivedual suitable medicine and dosage in the mode of attempting therapy to various kinds of drug.
Summary of the invention
One object of the present invention is to provide a kind of mouth ulcer paster that contains Herba Taraxaci and preparation method thereof.
The mouth ulcer paster that contains Herba Taraxaci of the present invention, one deck are the adhered layer that soluble high-molecular is formed pastille, and another layer is the protective layer of the molecular not pastille of insoluble high score.
Technical scheme of the present invention is as follows: a kind of mouth ulcer paster that contains Herba Taraxaci, adhesion layer and water-fast protective layer by pastille are formed, and wherein the pastille adhesion layer contains the extract that contains Herba Taraxaci, carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, the sodium carboxymethyl cellulose of 0.1～15mg; Water-fast protective layer is made up of ethyl cellulose, food coloring; The extract that contains Herba Taraxaci wherein is by Herba Menthae 1.5～12 grams, and Herba Taraxaci 1.5～20 restrains, Medulla Junci 5～10 grams, and Fructus Evodiae 10～15 grams are formed.
The mouth ulcer paster that contains Herba Taraxaci of the present invention, the extract preferred content that contains Herba Taraxaci wherein is 0.5～5mg.
The mouth ulcer paster that contains Herba Taraxaci of the present invention, it is 2-5mg that the extract that contains Herba Taraxaci wherein is more preferably content.
The mouth ulcer paster that contains Herba Taraxaci of the present invention, best technical scheme is: the adhesion layer of pastille contains extract 5mg, carbopol 3mg, Borneolum Syntheticum 8.5mg, low-substituted hydroxypropyl cellulose 8mg, sodium carboxymethyl cellulose 17mg, magnesium stearate 0.2mg, the Pulvis Talci 0.6mg of Herba Taraxaci; Water-fast protective layer contains ethyl cellulose 0.5～1.5mg, food coloring 1～2 μ g.
The mouth ulcer paster that contains Herba Taraxaci of the present invention, being prepared as of extract that contains Herba Taraxaci: with Herba Menthae 1.5～12 grams (preferred 1.5～5 grams), Herba Taraxaci 1.5～20 grams (preferred 1.～3 grams), Medulla Junci 5～10 grams, Fructus Evodiae 10～15 grams, use the 60-95% alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, eluent decolouring back concentrates, with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
In the research of biologic adhesion preparation, make medicine can stick to the mucosa position for a long time, will use the macromolecular material of biocompatibility, this material usually makes drug release very slow; But drug release is crossed to delay and can be caused drug level low, the performance that affects the treatment.Therefore, the research of biologic adhesion preparation need solve and adhere to effectiveness and this a pair of contradiction of curative effect of medication, generally is difficult to take into account.
Formulation and technology of the present invention is through research screening repeatedly, selected low-substituted hydroxypropyl cellulose, three kinds of macromolecular materials of different nature of sodium carboxymethyl cellulose and carbopol (Carbopol) are bioadhesive polymer and slow-release material, make paster stick to ulcer membranous part position, reach the purpose of site-specific delivery of drugs; Use Borneolum Syntheticum to be porogen and filler simultaneously, avoid drug release slow excessively; Add moderate lubrication agent and fluidizer magnesium stearate and Pulvis Talci at last, make bilayer tablet, well reached and effectively to have adhered to medicine-feeding part, again can be within a certain period of time (between two meal 3～4 hours) discharge the purpose of medicine fully, avoided the influence of feed simultaneously to administration, because used bioabsorbable polymer material has stronger adhesive capacity, can drink water during administration, not the adhesion of the paster that can influence.
The oral ulcer double-layer sticking tablet content that contains Herba Taraxaci of the present invention is 0.1～15mg, is preferably 0.5～5mg, and optimal dose is 2-3mg.
The prescription of explaining in the claim is the best proportioning of each supplementary product consumption, and the amount of increase and decrease 10% also can reach the adherent ability of drug release effect and location preferably on the basis of the existing consumption of each adjuvant.
Double layer design; protective layer selected for use ethyl cellulose this commonly used, under the pH condition of oral cavity insoluble macromolecular material; reduced dissolving and tablet the two-way adhesion gums and oral mucosa between of medicine to the offside of oral mucosa; medicine is infiltrated and the sense of discomfort of minimizing in the oral cavity to ulcer surface, make the patient more acceptant.
The protective layer macromolecular material that adopts in the preparation process except that ethyl cellulose, also available other insoluble macromolecular materials under the pH condition of oral cavity, as acrylic resin etc., though similar on the effect, more inferior than using ethyl cellulose on cost.Described pigment is generally food coloring, can be red pigment, flavochrome, cyanine, preferred flavochrome.
The mouth ulcer paster that contains Herba Taraxaci of the present invention prepares by the following method:
(1) contain being prepared as of extract of Herba Taraxaci: with Herba Menthae 8～12 grams, Herba Taraxaci 1.5～20 grams, Medulla Junci 5～10 grams, Fructus Evodiae 10～15 grams are used the 60-95% alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adds water and makes extractum become suspension, through macroporous resin, water elution, eluent decolouring back concentrates, and with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, filter, filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
(2) contain the extract and the Borneolum Syntheticum of Herba Taraxaci, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose mixes, and uses 30% alcohol granulation, drying; Add carbopol (Carbopol), Pulvis Talci and the magnesium stearate of recipe quantity, use flat stamping behind the mixing, the solution spraying that will contain ethyl cellulose and pigment by Membrane jetter is made protective layer in the tablet surface again, and natural drying gets final product.
The physicochemical property of each medical material of the present invention is as follows:
Herba Menthae: it is menthene, ocimene, Herba Menthae lactone, Herba Menthae lactone alcohol etc. that fruit contains volatile oil.Also contain Herba Menthae acid.Herba Menthae decoct (100%) has strong suppress to render a service (agar ditching flat band method) to vibrio cholera.10% water logging agent has inhibitory action to acrothesium floccosum in vitro; The stomachache, stomachache, cold syndrome of the stomach that is used for cold syndrome felt sick, vomiting, acid regurgitation.It is descending also can to ignite: control aphtha of the mouth and tongue.
Herba Taraxaci: be the pigment in the leaves such as Isatis indigotica Fort., Acanthaceous indigo, polygonum tinctorium ait., careless Folium Isatidis.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, clearing away liver-fire, dispelling wind and relieving convulsion. cure mainly maculae caused by violent heat pathogen, hematemesis and epistaxis, pathopyretic ulcer, sore throat mumps, cough with blood-flecked phlegm, convulsion with spasms.
Medulla Junci: Medulla Junci property is flat, and sweet in the mouth has detoxifcation, eliminates the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Medulla Junci invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and separate poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and big loose stool is thin, weak heating and cough, cardiopalmus etc.
Fructus Evodiae is Anacardiaceae machaka or dungarunga plant Fructus rhois chinensis, or parasitic insect gall on the blue or green bran Folium Populi Pseudo-simonii of congener.The function astringing intestine to stop diarrhea of astringing the lung, the hemostasis detoxifcation.Tradition is mainly used in diseases such as chronic cough, chronic dysentery, spontaneous perspiration, night sweat.Modern pharmacological research shows, effect such as Fructus Evodiae tool astringent therapy, antibiotic, antiviral can be used for the treatment of aphtha of the mouth and tongue.
This product is measured the release in vitro situation with reference to 2000 editions drug release determination methods of Chinese Pharmacopoeia, and the result shows that the double-deck oral cavity adhesion tablet of extract that contains Herba Taraxaci can continue to discharge 3～4 hours, can bring into play drug effect for a long time, alleviates the pain that ulcer is brought.
Product of the present invention is tested by placing each influence factor of 10 days under the conditions such as illumination (2500Lux), high temperature (40 ℃, 60 ℃), room temperature, the study on the stability that accelerated test (40 ℃, RH75%) three months and room temperature kept sample 24 months, its medicated layer character, related substance amount, dissolubility, content etc. have no significant change.
Product of the present invention has been carried out mucomembranous irritant test, adopted the extract adhesion tablet external application contain Herba Taraxaci local excitation experiment, observed Cavia porcellus oral mucosa after the drug of topical application, dermoreaction Cavia porcellus oral mucosa and intact skin, damaged skin.
The result: the extract ora adhesion tablet that contains Herba Taraxaci to Cavia porcellus oral mucosa and intact skin, the damaged skin drug of topical application after, Cavia porcellus oral mucosa and skin of back are not found local edema and obvious erythematous response, compare no significant difference with the skin of own control one side.Illustrate that this product does not have zest to mucosa.
Product of the present invention is used for the treatment of oral ulcer and mucositis, carried out 120 routine patients' clinical experiment altogether, counter point is at random adopted in experiment, test group (the extract ora adhesion tablet that contains Herba Taraxaci) 80 examples, matched group (comfort group, blank) 40 examples, dosage: one time 1 (2mg/ sheet), 4 times on the one.The course of treatment: recurrent aphtha: 4 days, mucositis 10 days.The result: test group and matched group total effective rate are respectively 95.3% and 31%.Wherein the recurrent aphtha effective percentage is respectively 96% and 38%, and the mucositis effective percentage is respectively 97% and 30%.Test group is compared with matched group, has significant curative effect.
Specifically prepare according to the following steps:
1. Herba Menthae 8～12 restrains, Herba Taraxaci 15～20 grams, and Medulla Junci 5～10 grams, Fructus Evodiae 10～15 grams boil 1-3 time through decocting, and each 2-3 hour, when the water extract is concentrated into proportion 1.2-1.4, high speed centrifugation;
2. centrifugal liquid or concentrate drying get crude extract;
3. macroporous resin through water elution, concentrates after the eluent decolouring, and with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Dosage form of the present invention is compared with existing membrane, monolayer patch, has following advantage:
1, this product has the adhesion layer that a side is a pastille; another layer is the characteristics of the double layer design of water-fast protective layer; can reduce dissolving and tablet the two-way adhesion gums and oral mucosa between of medicine, medicine is infiltrated and the sense of discomfort of minimizing in the oral cavity to ulcer surface to the offside of oral mucosa.
2, different with existing dosage form is that this product has the slow releasing function that reaches lasting release in 3-4 hour, can be positioned lesions position performance drug effect for a long time, alleviates the pain that ulcer is brought.Make the part that concentration higher, the long period be arranged and obtain curative effect preferably, thereby alleviate systemic side effects.
3, this dosage form confirms the mucosa nonirritant through the pharmacology zoopery, confirms through preliminary clinical experiment again, and the ulcer treatment rate can be up to more than 96%, and is evident in efficacy, is the novel form of present comparatively ideal treatment oral ulcer.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but not as limitation of the present invention.
Embodiment 1
1. Herba Menthae 8 restrains, Herba Taraxaci 15 grams, and Medulla Junci 5 grams, Fructus Evodiae 10 grams boil 3 times through decocting, and each 2 hours, when the water extract is concentrated into proportion 1.2-1.4, high speed centrifugation; 2. centrifugal liquid or concentrate drying get crude extract; 3. macroporous resin through water elution, concentrates after the eluent decolouring, and with 95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Embodiment 2
With Herba Menthae 12 grams, Herba Taraxaci 20 grams, Medulla Junci 10 grams, Fructus Evodiae 15 grams are used 75% alcohol reflux, extract 3 times, filtrate is condensed into extractum, adds water and makes extractum become suspension, through macroporous resin D301, water elution, eluent decolouring back concentrates, and with 95% ethanol precipitate with ethanol, refrigerator is placed, filter, filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Embodiment 3
Herba Menthae 10 grams, Herba Taraxaci 150 grams, Medulla Junci 8 grams, Fructus Evodiae 15 grams, with Herba Menthae 10 grams, Herba Taraxaci 150 grams, Medulla Junci 8 grams, Fructus Evodiae 15 grams are used 95% alcohol reflux, extract 2 times, filtrate is condensed into extractum, adds water and makes extractum become suspension, through macroporous resin D301, water elution, eluent decolouring back concentrates, with 95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Embodiment 4
Preparation contains the double-deck oral cavity adhesion tablet (1000) of extract of Herba Taraxaci
The extract 0.5g that contains Herba Taraxaci
Carbopol 3g
Borneolum Syntheticum 8.5g
Low-substituted hydroxypropyl cellulose 8g
Sodium carboxymethyl cellulose 17g
Magnesium stearate 0.2g
Pulvis Talci 0.8g
Ethyl cellulose 0.5g
Red pigment 1.5mg
Preparation technology:
The extract that contains Herba Taraxaci with recipe quantity, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose are crossed 100 mesh sieves respectively, abundant mixing, granulate through 30 mesh sieves, after 60 ℃ of oven dry, through 30 mesh sieve granulate, after adding the abundant mixing of carbopol, magnesium stearate, Pulvis Talci of 100 mesh sieves, with diameter 6mm flat punch tabletting promptly, every heavily about 40mg contains amlexanox 0.5mg.Ethyl cellulose 0.8g is dissolved with 95% alcohol 95 ml, add pigment 1mg, evenly be sprayed at the tablet surface, behind natural drying, form the protective layer of tablet with Membrane jetter.
The release in vitro situation result who contains the double-deck oral cavity adhesion tablet of extract of Herba Taraxaci according to the inspection of 2000 editions drug release determination methods of Chinese Pharmacopoeia shows that the sustainable slow release medicine of this product is about 4 hours.
This paster sticks time average and reaches 3.6 hours (n=5) in the healthy volunteer oral cavity.
Embodiment 1:
Preparation contains the double-deck oral cavity adhesion tablet (1000) of extract of Herba Taraxaci
The extract 2g that contains Herba Taraxaci
Carbopol 4.2g
Borneolum Syntheticum 7.5g
Low-substituted hydroxypropyl cellulose 8.1g
Sodium carboxymethyl cellulose 17g
Magnesium stearate 0.3g
Pulvis Talci 0.8g
Preparation technology:
The extract that contains Herba Taraxaci with recipe quantity, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose are crossed 100 mesh sieves respectively, abundant mixing, granulate through 30 mesh sieves, after 60 ℃ of oven dry, through 30 mesh sieve granulate, after adding the abundant mixing of carbopol, magnesium stearate, Pulvis Talci of 100 mesh sieves, with diameter 6mm flat punch tabletting promptly, every heavily about 42mg contains amlexanox 2mg.Ethyl cellulose 0.8 gram with 95% alcohol 95 ml dissolving, is added 1.5 milligrams of pigments, evenly be sprayed at the tablet surface, behind natural drying, form the protective layer of tablet with Membrane jetter.
Embodiment 2:
Preparation contains the double-deck oral cavity adhesion tablet (1000) of extract of Herba Taraxaci
The extract 5g that contains Herba Taraxaci
Carbopol 3.5g
Borneolum Syntheticum 6.5g
Low-substituted hydroxypropyl cellulose 4.5g
Sodium carboxymethyl cellulose 17g
Magnesium stearate 0.2g
Pulvis Talci 0.3g
Ethyl cellulose 1.8g
Flavochrome 2.9mg
Preparation technology:
The extract that contains Herba Taraxaci with recipe quantity, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose are crossed 100 mesh sieves respectively, abundant mixing, granulate through 30 mesh sieves, after 60 ℃ of oven dry, through 30 mesh sieve granulate, after adding the abundant mixing of carbopol, magnesium stearate, Pulvis Talci of 100 mesh sieves, with diameter 6mm flat punch tabletting promptly, every heavily about 45mg contains amlexanox 5mg.Ethyl cellulose 0.8 gram with 95% alcohol 95 ml dissolving, is added pigment 2mg, evenly be sprayed at the tablet surface, behind natural drying, form the protective layer of tablet with Membrane jetter.
The release in vitro situation result who contains the double-deck oral cavity adhesion tablet of extract of Herba Taraxaci according to the inspection of 2000 editions drug release determination methods of Chinese Pharmacopoeia shows that the sustainable slow release medicine of this product is about 4 hours.
This paster sticks time average and reaches 3.3 hours (n=5) in the healthy volunteer oral cavity.
Embodiment 3:
Preparation contains the double-deck oral cavity adhesion tablet (2000) of extract of Herba Taraxaci
The extract 10g that contains Herba Taraxaci
Carbopol 7.5g
Borneolum Syntheticum 1.7g
Low-substituted hydroxypropyl cellulose 16g
Sodium carboxymethyl cellulose 3.4g
Magnesium stearate 0.4g
Pulvis Talci 1.5g
Ethyl cellulose 1.1g
Flavochrome 2.4mg
Preparation technology: with embodiment one.
Claims (5)
1. mouth ulcer paster that contains Herba Taraxaci, adhesion layer and water-fast protective layer by pastille are formed, and wherein the pastille adhesion layer contains the extract that contains Herba Taraxaci, carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, the sodium carboxymethyl cellulose of 0.1～15mg; Water-fast protective layer is made up of ethyl cellulose, food coloring; The extract that contains Herba Taraxaci wherein is by Herba Menthae 1.5～12 grams, and Herba Taraxaci 15～20 restrains, Medulla Junci 5～10 grams, and Fructus Evodiae 10～15 grams are formed.
2. the mouth ulcer paster that contains Herba Taraxaci as claimed in claim 1, the extractive content that contains Herba Taraxaci wherein is 0.5～5mg.
3. the mouth ulcer paster that contains Herba Taraxaci as claimed in claim 1, the extractive content that contains Herba Taraxaci wherein is 2-5mg.
4. the mouth ulcer paster that contains Herba Taraxaci as claimed in claim 1, wherein the adhesion layer of pastille extract 5mg, the carbopol 3mg, Borneolum Syntheticum 8.5mg, low-substituted hydroxypropyl cellulose 8mg, sodium carboxymethyl cellulose 17mg, magnesium stearate 0.2mg, the water-fast protective layer of Pulvis Talci 0.6mg that contain Herba Taraxaci contains ethyl cellulose 0.5～1.5mg, food coloring 1～2 μ g.
5. as the described mouth ulcer paster that contains Herba Taraxaci of claim 1-4, being prepared as of extract that wherein contains Herba Taraxaci: with Herba Menthae 1.5～12 grams, Herba Taraxaci 15～20 grams, Medulla Junci 5～10 grams, Fructus Evodiae 10～15 grams, use the 60-95% alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, eluent decolouring back concentrates, with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105524804A CN102028825A (en) | 2010-11-19 | 2010-11-19 | Dental ulcer tablet containing dandelion and preparation method thereof |
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| CN2010105524804A CN102028825A (en) | 2010-11-19 | 2010-11-19 | Dental ulcer tablet containing dandelion and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579863A (en) * | 2012-01-18 | 2012-07-18 | 王磊 | Traditional Chinese medicine oral paster and preparation method thereof |
| CN103767970A (en) * | 2014-01-15 | 2014-05-07 | 孙亚男 | Oral care preparation and preparation method thereof |
| CN106137995A (en) * | 2016-08-18 | 2016-11-23 | 上海颂露医药科技有限公司 | Tianwangbuxin pills and preparation method thereof |
| CN109480048A (en) * | 2018-12-04 | 2019-03-19 | 广州医科大学 | A kind of dandelion chewing gum and preparation method thereof for treating canker sore |
-
2010
- 2010-11-19 CN CN2010105524804A patent/CN102028825A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579863A (en) * | 2012-01-18 | 2012-07-18 | 王磊 | Traditional Chinese medicine oral paster and preparation method thereof |
| CN102579863B (en) * | 2012-01-18 | 2014-04-09 | 山东大学齐鲁医院 | Traditional Chinese medicine oral paster and preparation method thereof |
| CN103767970A (en) * | 2014-01-15 | 2014-05-07 | 孙亚男 | Oral care preparation and preparation method thereof |
| CN103767970B (en) * | 2014-01-15 | 2015-11-25 | 孙亚男 | A kind of oral care formulations and preparation method thereof |
| CN106137995A (en) * | 2016-08-18 | 2016-11-23 | 上海颂露医药科技有限公司 | Tianwangbuxin pills and preparation method thereof |
| CN109480048A (en) * | 2018-12-04 | 2019-03-19 | 广州医科大学 | A kind of dandelion chewing gum and preparation method thereof for treating canker sore |
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Application publication date: 20110427 |