CN102579863B - Traditional Chinese medicine oral paster and preparation method thereof - Google Patents
Traditional Chinese medicine oral paster and preparation method thereof Download PDFInfo
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- CN102579863B CN102579863B CN201210014814.1A CN201210014814A CN102579863B CN 102579863 B CN102579863 B CN 102579863B CN 201210014814 A CN201210014814 A CN 201210014814A CN 102579863 B CN102579863 B CN 102579863B
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 10
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 10
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 7
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 14
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Abstract
The invention provides a traditional Chinese medicine oral paster used for treating canker sore, which consists of an adhesion layer containing a medicine and a water-insoluble protection layer, wherein the adhesion layer containing the medicine contains traditional Chinese medicine extract. The traditional Chinese medicine oral paster is characterized in that the traditional Chinese medicine extract comprises the extracts of the following components: citrus, rheum officinale, parasitic loranthus, common lophatherum herb, poria cocos, rehmannia glutinosa libosch, rhizoma bletillae, dwarf lilyturf tuber, radix paeoniae alba, Chinese yam, oldenlandia diffusa, barbed skullcap herb, rhizoma cimicifugae, medicated leaven and rhizoma alismatis. The traditional Chinese medicine oral paster has the advantages of being rapid in treatment effect, high in cure rate, low in cost, long in medicine effect time and the like when used for treating canker sore.
Description
Technical field
The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese medicine oral paster for the treatment of oral ulcer
Background technology
Oral ulcer, is among the peoplely generally referred to as " getting angry in oral cavity " or " aphtha ", is a kind of oral mucosa limitation ulcerative lesions that periodically outbreak is feature repeatedly of take, can spontaneous recovery, can occur in any position of oral mucosa.The mucosa of locating with lip, cheek, soft palate or the gums etc. in oral cavity is common, there is single or a plurality of circular or oval ulcer differing in size, greyish white or the yellow pseudomembrane of surface coverage, concavity, clear border, around mucosa is red and micro-swollen, and the local causalgia of ulcer is obvious, has the feature of periodicity, recurrent, self limiting.Oral ulcer is called again recurrent aphtha stomatitis (recurrent aphthous stomatitis, RAS), recurrent oral ulceration (recurrent oral ulcer, ROU), recurrent aphtha.Motherland's medical circle is on the books to oral ulcer already.According to the theoretical system of the traditional Chinese medical science, oral ulcer has following several cause of disease: the one, and diseases caused by exogenous pathogenic factor six climate exopathogens, are mainly dry, fiery two heresies, pathogenic dryness is dry and astringent, easy impairment of body fluid liquid, fire belongs with yang is evil, and in its property inflammation, Tianjin wound fire burns, and aphtha is to send out.Therefore how in the fall and easily recur during abrupt change of climate aphtha.The 2nd, eating and drinking without temperance, product or monophagia due to the pungent plumpness of surfeit, cause endogenous fire formation, follow through on attack, stifling dispute, and often consume cloudy Tianjin of sad lung kidney, causes aphtha and occurs.The 3rd, emotional stress, patient is excessive thinking generally, dysphoria and insomnia, the strongly fragrant and fire-transformation of five will, hyperactivity of heart-fire, the smoked dispute of burning of upper inflammation, or heart-fire moving downward is in small intestinal, follow through on attack Yu Kou, all can cause aphtha of the mouth and tongue; Or usually have disgruntled, stagnation of QI due to depression of the liver, irritability is not dredged, strongly fragrant and fire-transformation secretly consumes cloudy blood, causes punching to appoint passages through which vital energy circulates uncomfortable, in row, through the stagnation of QI, holds back more very, liver-fire is vigorous, upper bright dispute and cause aphtha.The 4th, plain body is cloudy to be lost, patient's element body YIN-fluid being insufficient, or the cloudy damage of prolonged illness, deficiency-fire produced in the interior, the dispute of burning, and even aphtha of the mouth and tongue.The 5th, overstrain internal injury, or the prolonged illness impairment of the spleen, damage of spleen-QI, water is wet not to be transported, upper stain dispute, and cause aphtha; Or strongly fragrant heat-transformation of a specified duration, damp and hot upper steaming, also can cause aphtha.What is more, and temper fictitious pole injures spleen sun, spleen YANG deficiency, cold-damp heat-dissipating, on steep in mouth, can send out aphtha.The 6th, congenital examining composed not enoughly, or uses for a long time cold and coolly, injures spleen kidney, and deficiency of spleen-YANG and kidneyYANG is yin-cold excess, steeps dispute in cold-damp, and blood stasis due to accumulation of cold, causes aphtha of the mouth and tongue for a long time.Diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire in a word, interior impairment of ZANG FU-organs intenseness of heat is the main cause of causing a disease, the dirty heart and the spleen (stomach) of being of main disease.The medicine that is used at present this disease for the treatment of is steroid dose, antibiotic, immunosuppressant, antihistaminic etc. mostly.At present the Chinese medicine of this disease for the treatment of comprises two kinds of medicine for external use and oral medicine, and these medicines carry out part alleviation or treat oral ulcer, cannot solve the problem that intractable oral cavity ulcer disease is shown effect repeatedly.Oral medicine does not have special specific aim, and the course of disease is long, though can control oral ulcer recurrence, said medicine or because for the treatment of time longer, or because price is more expensive, so development good effect, price is low, preparation easy to use remains the problem that we need to solve.
Summary of the invention
Technical problem to be solved by this invention is that Chinese medicine oral paster providing a kind of novel treatment oral ulcer and preparation method thereof is provided, adopt this Chinese medicine oral paster to there is curative effect to the treatment of oral ulcer fast, the advantages such as cure rate is high, and cost is low, and effective drug duration is long.
Adopt the mode of oral paster can phenomenal growth effective drug duration, meanwhile, the Chinese medicine extract drug effect of using in the present invention be excellent especially, and the combination of two kinds of modes makes drug effect performance especially abundant.
In order to solve the problems of the technologies described above; the invention provides a kind of Chinese medicine oral paster for the treatment of oral ulcer; this Chinese medicine oral paster is comprised of adhesion layer and the water-fast protective layer of pastille; wherein pastille adhesion layer contains Chinese medicine extract; it is characterized in that: the extract that Chinese medicine extract wherein contains following component: Citrus, Radix Et Rhizoma Rhei, Herba Taxilli; Herba Lophatheri, Poria, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ophiopogonis, the Radix Paeoniae Alba, Rhizoma Dioscoreae Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Rhizoma Cimicifugae, Massa Medicata Fermentata and Rhizoma Alismatis.
Wherein, the Chinese medicine extract that pastille adhesion layer contains 0.1～15mg.
Wherein, pastille adhesion layer also contains carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose.
Wherein, water-fast protective layer is comprised of ethyl cellulose, food coloring
Wherein, the ratio of weight and number of each component of each Chinese medicinal components of using in described Chinese medicine extract is, Citrus 100-110 part, Radix Et Rhizoma Rhei 110-130 part, Herba Taxilli 20-40 part, Herba Lophatheri 5-15 part, Poria 10-15 part, Radix Rehmanniae 4-8 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1.5-3 part, Radix Ophiopogonis 6-8 part, Radix Paeoniae Alba 5-8 part, Rhizoma Dioscoreae 2-20 part, Herba Hedyotidis Diffusae 1-5 part, Herba Scutellariae Barbatae 1-5 part, Rhizoma Cimicifugae 1-2 part, Massa Medicata Fermentata 5-7 part, Rhizoma Alismatis 5-15 part.
Wherein, each Chinese medicinal components of using in described Chinese medicine extract also comprises Fructus Crataegi and Radix Angelicae Sinensis, and the ratio of weight and number of each component in described Fructus Crataegi, Radix Angelicae Sinensis and described Chinese medicine composition is, Fructus Crataegi 3～5 weight portion Radix Angelicae Sinensis 10-25 weight portions.
Wherein, each Chinese medicinal components of using in described Chinese medicine extract also comprises Radix Trichosanthis and Fructus Corni, and the ratio of weight and number of each component in described Radix Trichosanthis and Fructus Corni and described Chinese medicine composition is, Radix Trichosanthis 5.6～7 weight portions, Fructus Corni 10 weight portions.
Wherein, the adhesion layer of pastille contains Chinese medicine extract 3-10mg, carbopol 2-4mg, Borneolum Syntheticum 8-9mg, low-substituted hydroxypropyl cellulose 5-10mg, sodium carboxymethyl cellulose 10-20mg, magnesium stearate 0.1-0.5mg, Pulvis Talci 0.1-1mg; Water-fast protective layer contains ethyl cellulose 0.1～3mg, food coloring 1～5 μ g.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine oral paster, it is characterized in that: comprise the following steps:
(1) by each Chinese medicinal components alcohol reflux using in described Chinese medicine extract, extract 2-3 time, filtrate is condensed into extractum, add water and make extractum become suspension, through macroporous resin, water elution, concentrated after eluent decolouring, vacuum drying, pulverize and sieve or the dry coal of spraying obtains fine-powdered extract;
(2) Chinese medicine extract mixes with Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose, granulates, dry; Add carbopol, Pulvis Talci and magnesium stearate, mix rear tabletting, stopping off.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine oral paster for the treatment of oral ulcer, it is characterized in that, described Chinese medicine oral paster is prepared from by the following method:
(1) by each Chinese medicinal components alcohol reflux using in described Chinese medicine extract, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, concentrated after eluent decolouring, vacuum drying, pulverize and sieve or the dry fine-powdered extract that obtains of spraying, wherein, Chinese medicine extract comprises Citrus, Radix Et Rhizoma Rhei, Herba Taxilli, Herba Lophatheri, Poria, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ophiopogonis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Rhizoma Cimicifugae, Massa Medicata Fermentata, Rhizoma Alismatis;
(2) Chinese medicine extract mixes with Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose; Add carbopol, Pulvis Talci and magnesium stearate, mix rear tabletting, stopping off.
The advantages such as it is fast that the present invention adopts this this Chinese medicine oral paster to have curative effect to the treatment of oral ulcer, and cure rate is high, and cost is low, and effective drug duration is long.
The specific embodiment
The invention provides a kind of Chinese medicine oral paster for the treatment of oral ulcer, this Chinese medicine oral paster is comprised of adhesion layer and the water-fast protective layer of pastille, and wherein pastille adhesion layer contains Chinese medicine extract, carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose; Water-fast protective layer is comprised of ethyl cellulose, food coloring; It is characterized in that: each Chinese medicinal components of using in described Chinese medicine extract comprises: Citrus, Radix Et Rhizoma Rhei, Herba Taxilli, Herba Lophatheri, Poria, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ophiopogonis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Rhizoma Cimicifugae, Massa Medicata Fermentata, Rhizoma Alismatis.
The ratio of weight and number of each Chinese medicinal components of using in described Chinese medicine extract is preferably, Citrus 100-110 part, Radix Et Rhizoma Rhei 110-130 part, Herba Taxilli 20-40 part, Herba Lophatheri 5-15 part, Poria 10-15 part, Radix Rehmanniae 4-8 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1.5-3 part, Radix Ophiopogonis 6-8 part, Radix Paeoniae Alba 5-8 part, Rhizoma Dioscoreae 2-20 part, Herba Hedyotidis Diffusae 1-5 part, Herba Scutellariae Barbatae 1-5 part, Rhizoma Cimicifugae 1-2 part, Massa Medicata Fermentata 5-7 part, Rhizoma Alismatis 5-15 part.
The ratio of weight and number of each Chinese medicinal components of using in described Chinese medicine extract more preferably, Citrus 103-108 part, Radix Et Rhizoma Rhei 105-120 part, Herba Taxilli 25-35 part, Herba Lophatheri 8-12 part, Poria 12-14 part, Radix Rehmanniae 5-7 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5-3 part, Radix Ophiopogonis 7-8 part, Radix Paeoniae Alba 6-8 part, Rhizoma Dioscoreae 10-20 part Herba Hedyotidis Diffusae 2-4 part, Herba Scutellariae Barbatae 2-4 part, Rhizoma Cimicifugae 1-2 part, Massa Medicata Fermentata 6-7 part, Rhizoma Alismatis 10-15 part
Each Chinese medicinal components of using in described Chinese medicine extract also comprises Fructus Crataegi and Radix Angelicae Sinensis, the ratio of weight and number of each component in described Fructus Crataegi, Radix Angelicae Sinensis and described Chinese medicine composition is preferably, Fructus Crataegi 3～5 weight portions, Radix Angelicae Sinensis 10-25 weight portion, Fructus Crataegi 4 weight portions more preferably, Radix Angelicae Sinensis 15-20 weight portion.
Each Chinese medicinal components of using in described Chinese medicine extract also comprises Radix Trichosanthis and Fructus Corni, and the ratio of weight and number of each component in described Radix Trichosanthis and Fructus Corni and described Chinese medicine composition is preferably, Radix Trichosanthis 5.6～7 weight portions, Fructus Corni 10 weight portions; More preferably, Radix Trichosanthis 6 weight portions, Fructus Corni 10 weight portions.
The adhesion layer of pastille preferably contains Chinese medicine extract 3-10mg, carbopol 2-4mg, Borneolum Syntheticum 8-9mg, low-substituted hydroxypropyl cellulose 5-10mg, sodium carboxymethyl cellulose 10-20mg, magnesium stearate 0.1-0.5mg, Pulvis Talci 0.1-1mg, water-fast protective layer contains ethyl cellulose 0.1～3mg, food coloring 1～5 μ g; Further preferably contain Chinese medicine extract 4-10mg, carbopol 3-4mg, Borneolum Syntheticum 8-9mg, low-substituted hydroxypropyl cellulose 6-10mg, sodium carboxymethyl cellulose 15-20mg, magnesium stearate 0.3-0.5mg, Pulvis Talci 0.5-1mg; Water-fast protective layer contains ethyl cellulose 0.8～3mg, food coloring 3～5 μ g
The preparation method of Chinese medicine oral paster comprises the following steps:
(1) by each component alcohol reflux in Chinese medicine extract, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, concentrated after eluent decolouring, vacuum drying (can auxiliary heating), pulverize and sieve or the dry fine-powdered extract that obtains of spraying;
(2) Chinese medicine extract mixes (can be dry mixed or add solvent, after interpolation solvent, need to be dried) with Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose; Add carbopol, Pulvis Talci and magnesium stearate, mix rear tabletting, stopping off.
This product is with reference to 2000 editions drug release determination methods of Chinese Pharmacopoeia, measures release in vitro situation, and result shows, the double-deck oral cavity adhesion tablet energy of Chinese medicine extract sustained release 3～4 hours, can bring into play drug effect for a long time, alleviates the pain that ulcer is brought.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1
The Chinese medicinal components of using: Citrus 110g, Radix Et Rhizoma Rhei 110g, Herba Taxilli 30g, Herba Lophatheri 10g, Poria 10g, Radix Rehmanniae 6g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5g, Radix Ophiopogonis 7g, Radix Paeoniae Alba 7g, Rhizoma Dioscoreae 15g, Herba Hedyotidis Diffusae 3g, Herba Scutellariae Barbatae 3g, Rhizoma Cimicifugae 2g, Massa Medicata Fermentata 6g, Rhizoma Alismatis 13g, after being mixed, these components use alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, concentrated after eluent decolouring, vacuum drying (can auxiliary heating), pulverize and sieve or the dry fine-powdered extract that obtains of spraying;
(2) Chinese medicine extract 0.5g and Borneolum Syntheticum 0.8g, low-substituted hydroxypropyl cellulose 0.5g, sodium carboxymethyl cellulose mixing 1g, be uniformly mixed, and adds carbopol 0.3g, Pulvis Talci 0.1g and magnesium stearate 0.03g, mixes rear tabletting (100); To with 95% alcohol 95 ml, dissolve containing ethyl cellulose 0.2g, add pigment 0.1mg, be sprayed at tablet surface, after natural drying, form the protective layer of tablet.Make paster 1 after measured, medicine energy sustained release 3.5 hours.
Embodiment 2: in the Chinese medicinal components of embodiment 1, further add Fructus Crataegi 4g, and Radix Angelicae Sinensis 15g, other components and technique make paster 2 with embodiment 1.After measured, medicine energy sustained release is 3.5 hours.
Embodiment 3: in the Chinese medicinal components of embodiment 3, further add Radix Trichosanthis 6g, Fructus Corni 10g, other components and technique make paster 3 with embodiment 2.After measured, medicine energy sustained release is 3.5 hours.
100 routine Blood of Patients with Recurrent Orals are carried out to the test of pesticide effectiveness, are divided into four groups (every group of 25 people), use respectively paster 1,2,3 and blank, one time 1 slice/day.After 3 days, result shows, the effective percentage of recurrent oral ulceration is respectively to 100%, 100%, 100% and 40%, and recovery from illness patient number is respectively: 23,24,25,8.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (4)
1. a Chinese medicine oral paster for the treatment of oral ulcer, this Chinese medicine oral paster is comprised of adhesion layer and the water-fast protective layer of pastille, wherein pastille adhesion layer contains Chinese medicine extract, it is characterized in that: the extract that Chinese medicine extract is wherein following component: Citrus, Radix Et Rhizoma Rhei, Herba Taxilli, Herba Lophatheri, Poria, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ophiopogonis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Rhizoma Cimicifugae, Massa Medicata Fermentata and Rhizoma Alismatis, wherein, the ratio of weight and number of described component is, Citrus 100-110 part, Radix Et Rhizoma Rhei 110-130 part, Herba Taxilli 20-40 part, Herba Lophatheri 5-15 part, Poria 10-15 part, Radix Rehmanniae 4-8 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1.5-3 part, Radix Ophiopogonis 6-8 part, Radix Paeoniae Alba 5-8 part, Rhizoma Dioscoreae 2-20 part, Herba Hedyotidis Diffusae 1-5 part, Herba Scutellariae Barbatae 1-5 part, Rhizoma Cimicifugae 1-2 part, Massa Medicata Fermentata 5-7 part, Rhizoma Alismatis 5-15 part.
2. Chinese medicine oral paster as claimed in claim 1, wherein, the Chinese medicine extract that pastille adhesion layer contains 0.1～15mg.
3. the Chinese medicine oral paster as described in any one in claim 1-2, wherein, pastille adhesion layer also contains carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose.
4. the Chinese medicine oral paster as described in any one in claim 1-2, wherein, water-fast protective layer is comprised of ethyl cellulose, food coloring.
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| CN1426689A (en) * | 2001-12-21 | 2003-07-02 | 张莹 | Chinese medicine antiseptic |
| CN101700299A (en) * | 2009-11-19 | 2010-05-05 | 张晓玲 | Traditional Chinese medicine preparation for curing oral ulcer |
| CN102028825A (en) * | 2010-11-19 | 2011-04-27 | 天津太平洋制药有限公司 | Dental ulcer tablet containing dandelion and preparation method thereof |
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|---|---|---|---|---|
| CN1426689A (en) * | 2001-12-21 | 2003-07-02 | 张莹 | Chinese medicine antiseptic |
| CN101700299A (en) * | 2009-11-19 | 2010-05-05 | 张晓玲 | Traditional Chinese medicine preparation for curing oral ulcer |
| CN102028825A (en) * | 2010-11-19 | 2011-04-27 | 天津太平洋制药有限公司 | Dental ulcer tablet containing dandelion and preparation method thereof |
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