CN102048816A - Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof - Google Patents
Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof Download PDFInfo
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- CN102048816A CN102048816A CN2009100711962A CN200910071196A CN102048816A CN 102048816 A CN102048816 A CN 102048816A CN 2009100711962 A CN2009100711962 A CN 2009100711962A CN 200910071196 A CN200910071196 A CN 200910071196A CN 102048816 A CN102048816 A CN 102048816A
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Abstract
The invention relates to a Chinese medicinal double-layer patch for treating oral ulcer. The patch consists of a medicine-containing adhesion layer and a water-insoluble protective layer, wherein the medicine-containing adhesion layer comprises 0.1 to 15mg of Chinese medicinal extract, carbopol, borneol, low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose; the water-insoluble protective layer consists of ethyl cellulose and edible pigment; and the Chinese medicinal extract consists of 8 to 12g of mint, 15 to 20g of honeysuckle flower, 5 to 10g of liquoric root and 10 to 15g of Chinese gall. The double-layer patch medicine can fully improve local ulcer tissues and repair and cure the ulcer soon to fulfill the aim of treatment; the Chinese patent medicine is nontoxic and harmless to human bodies, is not required to be decocted and is convenient to administrate; the patch treats both symptoms and root causes and has obvious clinical curative effects; and the effective rate reaches 96 percent.
Description
Technical field
The present invention relates to treat the medicine of oral disease, particularly relate to a kind of Chinese medicine stomatocace double-layer paster and preparation method thereof.
Technical background
Recurrent oral ulceration also claims recurrent aphtha, in the many diseases in oral cavity, except dental caries and periodontal disease, just belongs to recurrent ulcer and makes us puzzlement most.It is often invaded in the oral cavity repeatedly, the epithelium of non-keratinization, for example lip mucosa, cheek mucosa and lingual mucous membrane etc., cause the patient speak, swallow with diet on puzzlement and inconvenience.As far back as the 19th-century end, just intactly put down in writing the course of disease of recurrent oral ulceration in history, in initial 24 hours, its symptom is also not obvious, some people may have the prodrome of twinge or causalgia, and two to three days afterwards, the affected part produced red macule or pimple, its epithelium forms ulcer by corrosion and then in focus central authorities, and enlarge outward gradually, the pain increased, the rounded or oval of its outward appearance, affected part central part depression, peripheral erythema haloing is one of its characteristic.About five to seven days, the ulcer surface was gradually covered by the fibroid eschar, and pain gradually relaxes, and ulcer also begins healing, and erythema fades away, and it is smooth that mucous membrane surface recovers again.Unless ulcer is very dark, can not stay cicatrix usually.This light-duty recurrent oral ulceration, when showing effect at every turn, about one to five of its focus number, the diameter of each focus is less than one centimeter, and pilosity is born in non-keratinization oral mucosa, and whole focus is fortnight approximately.In addition, still have heavy and bubble rash type recurrent ulcer, its infection wider, the focus number and the state of an illness are all heavier, and only this two classes recurrent ulcer is comparatively rare.Really cause the reason of recurrent oral ulceration, still not fully aware of so far, only suspecting may be relevant with the autoimmune disease that oral cavity infection or cross reaction are caused.But on the contrary many for the research of oral ulcer inducement.Wherein more valued inducement as: the patient of most of recurrent oral ulcerations once had the medical history of previous wound, and therefore, wound may be one of inducement.
The variation of hormone in vivo is also relevant with the incidence rate of ulcer, and the normal complaint of female patient is higher through the situation that last week ulcer takes place, and is then on the low side in women's incidence rate of pregnancy.And pressure and emotional factor often are considered to the major incentive of recurrent ulcer especially.In addition, some anaphylactogen also may see through a succession of reaction and cause ulcer.Because it is the cause of disease determines so far as yet, therefore still on the low side for the expection of the prevention of this disease and therapeutic outcome.Being used in the medicine of this disease of treatment at present, is steroid dose, antibiotic, immunosuppressant, antihistaminic and astringent etc. mostly.The Amlexanox oral patch that the U.S. releases recently has better curative effect to light-duty recurrent oral ulceration.Because of reaction and the difference of patient,,,, can make the order of severity of effective disease controlling and shorten the course of disease time promptly with administration if can send out in early days in disease so should find out indivedual suitable medicine and dosage in the mode of attempting therapy to various kinds of drug.
Summary of the invention
One object of the present invention is to provide a kind of Chinese medicine stomatocace double-layer paster and preparation method thereof.
Chinese medicine stomatocace double-layer paster of the present invention, one deck are the adhered layer that soluble high-molecular is formed pastille, and another layer is the protective layer of the molecular not pastille of insoluble high score.
Technical scheme of the present invention is as follows: a kind of Chinese medicine stomatocace double-layer paster, adhesion layer and water-fast protective layer by pastille are formed, and wherein the pastille adhesion layer contains Chinese medicine extract, carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, the sodium carboxymethyl cellulose of 0.1～15mg; Water-fast protective layer is made up of ethyl cellulose, food coloring; Chinese medicine extract wherein is by Herba Menthae 1.5～12 grams, and Flos Lonicerae 1.5～20 restrains, Radix Glycyrrhizae 5～10 grams, and Galla Chinensis 10～15 grams are formed.
Chinese medicine stomatocace double-layer paster of the present invention, Chinese medicine extract preferred content wherein is 0.5～5mg.
It is 2-5mg that Chinese medicine stomatocace double-layer paster of the present invention, Chinese medicine extract wherein are more preferably content.
Chinese medicine stomatocace double-layer paster of the present invention, best technical scheme is: the adhesion layer of pastille contains Chinese medicine extract 5mg, carbopol 3mg, Borneolum Syntheticum 8.5mg, low-substituted hydroxypropyl cellulose 8mg, sodium carboxymethyl cellulose 17mg, magnesium stearate 0.2mg, Pulvis Talci 0.6mg; Water-fast protective layer contains ethyl cellulose 0.5～1.5mg, food coloring 1～2 μ g.
Chinese medicine stomatocace double-layer paster of the present invention, being prepared as of Chinese medicine extract: with Herba Menthae 1.5～12 grams (preferred 1.5～5 grams), Flos Lonicerae 1.5～20 grams (preferred 1.5～3 grams), Radix Glycyrrhizae 5～10 grams, Galla Chinensis 10～15 grams, use the 60-95% alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, eluent decolouring back concentrates, with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
In the research of biologic adhesion preparation, make medicine can stick to the mucosa position for a long time, will use the macromolecular material of biocompatibility, this material usually makes drug release very slow; But drug release is crossed to delay and can be caused drug level low, the performance that affects the treatment.Therefore, the research of biologic adhesion preparation need solve and adhere to effectiveness and this a pair of contradiction of curative effect of medication, generally is difficult to take into account.
Formulation and technology of the present invention is through research screening repeatedly, selected low-substituted hydroxypropyl cellulose, three kinds of macromolecular materials of different nature of sodium carboxymethyl cellulose and carbopol (Carbopol) are bioadhesive polymer and slow-release material, make paster stick to ulcer membranous part position, reach the purpose of site-specific delivery of drugs; Use Borneolum Syntheticum to be porogen and filler simultaneously, avoid drug release slow excessively; Add moderate lubrication agent and fluidizer magnesium stearate and Pulvis Talci at last, make bilayer tablet, well reached and effectively to have adhered to medicine-feeding part, again can be within a certain period of time (between two meal 3～4 hours) discharge the purpose of medicine fully, avoided the influence of feed simultaneously to administration, because used bioabsorbable polymer material has stronger adhesive capacity, can drink water during administration, not the adhesion of the paster that can influence.
Chinese medicine oral ulcer double-layer sticking tablet content of the present invention is 0.1～15mg, is preferably 0.5～5mg, and optimal dose is 2-3mg.
The prescription of explaining in the claim is the best proportioning of each supplementary product consumption, and the amount of increase and decrease 10% also can reach the adherent ability of drug release effect and location preferably on the basis of the existing consumption of each adjuvant.
Double layer design; protective layer selected for use ethyl cellulose this commonly used, under the pH condition of oral cavity insoluble macromolecular material; reduced dissolving and tablet the two-way adhesion gums and oral mucosa between of medicine to the offside of oral mucosa; medicine is infiltrated and the sense of discomfort of minimizing in the oral cavity to ulcer surface, make the patient more acceptant.
The protective layer macromolecular material that adopts in the preparation process except that ethyl cellulose, also available other insoluble macromolecular materials under the pH condition of oral cavity, as acrylic resin etc., though similar on the effect, more inferior than using ethyl cellulose on cost.Described pigment is generally food coloring, can be red pigment, flavochrome, cyanine, preferred flavochrome.
Chinese medicine stomatocace double-layer paster of the present invention prepares by the following method:
(1) being prepared as of Chinese medicine extract: with Herba Menthae 8～12 grams, Flos Lonicerae 1.5～20 grams, Radix Glycyrrhizae 5～10 grams, Galla Chinensis 10～15 grams are used the 60-95% alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adds water and makes extractum become suspension, through macroporous resin, water elution, eluent decolouring back concentrates, and with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, filter, filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
(2) Chinese medicine extract and Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose mixes, and uses 30% alcohol granulation, drying; Add carbopol (Carbopol), Pulvis Talci and the magnesium stearate of recipe quantity, use flat stamping behind the mixing, the solution spraying that will contain ethyl cellulose and pigment by Membrane jetter is made protective layer in the tablet surface again, and natural drying gets final product.
The physicochemical property of each medical material of the present invention is as follows:
Herba Menthae: it is menthene, ocimene, Herba Menthae lactone, Herba Menthae lactone alcohol etc. that fruit contains volatile oil.Also contain Herba Menthae acid.Herba Menthae decoct (100%) has strong suppress to render a service (agar ditching flat band method) to vibrio cholera.10% water logging agent has inhibitory action to acrothesium floccosum in vitro; The stomachache, stomachache, cold syndrome of the stomach that is used for cold syndrome felt sick, vomiting, acid regurgitation.It is descending also can to ignite: control aphtha of the mouth and tongue.
Flos Lonicerae: be the pigment in the leaves such as Isatis indigotica Fort., Acanthaceous indigo, polygonum tinctorium ait., careless Folium Isatidis.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, clearing away liver-fire, dispelling wind and relieving convulsion. cure mainly maculae caused by violent heat pathogen, hematemesis and epistaxis, pathopyretic ulcer, sore throat mumps, cough with blood-flecked phlegm, convulsion with spasms.
Radix Glycyrrhizae: Radix Glycyrrhizae property is flat, and sweet in the mouth has detoxifcation, eliminates the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and separate poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and big loose stool is thin, weak heating and cough, cardiopalmus etc.
Galla Chinensis: Galla Chinensis is Anacardiaceae machaka or dungarunga plant Fructus rhois chinensis, or parasitic insect gall on the blue or green bran Folium Populi Pseudo-simonii of congener.The function astringing intestine to stop diarrhea of astringing the lung, the hemostasis detoxifcation.Tradition is mainly used in diseases such as chronic cough, chronic dysentery, spontaneous perspiration, night sweat.Modern pharmacological research shows, effect such as Galla Chinensis tool astringent therapy, antibiotic, antiviral can be used for the treatment of aphtha of the mouth and tongue.
This product is measured the release in vitro situation with reference to 2000 editions drug release determination methods of Chinese Pharmacopoeia, and the result shows that the double-deck oral cavity adhesion tablet of Chinese medicine extract can continue to discharge 3～4 hours, can bring into play drug effect for a long time, alleviates the pain that ulcer is brought.
Product of the present invention is tested by placing each influence factor of 10 days under the conditions such as illumination (2500Lux), high temperature (40 ℃, 60 ℃), room temperature, the study on the stability that accelerated test (40 ℃, RH75%) three months and room temperature kept sample 24 months, its medicated layer character, related substance amount, dissolubility, content etc. have no significant change.
Product of the present invention has been carried out mucomembranous irritant test, adopted the local excitation experiment of Chinese medicine extract adhesion tablet external application, observed Cavia porcellus oral mucosa after the drug of topical application, dermoreaction Cavia porcellus oral mucosa and intact skin, damaged skin.
The result: the Chinese medicine extract oral cavity adhesion tablet to Cavia porcellus oral mucosa and intact skin, the damaged skin drug of topical application after, Cavia porcellus oral mucosa and skin of back are not found local edema and obvious erythematous response, compare no significant difference with the skin of own control one side.Illustrate that this product does not have zest to mucosa.
Product of the present invention is used for the treatment of oral ulcer and mucositis, carries out 120 routine patients' clinical experiment altogether, and counter point is at random adopted in experiment, test group (Chinese medicine extract oral cavity adhesion tablet) 80 examples, matched group (comfort group, blank) 40 examples, dosage: one time 1 (2mg/ sheet), 4 times on the one.The course of treatment: recurrent aphtha: 4 days, mucositis 10 days.The result: test group and matched group total effective rate are respectively 95.3% and 31%.Wherein the recurrent aphtha effective percentage is respectively 96% and 38%, and the mucositis effective percentage is respectively 97% and 30%.Test group is compared with matched group, has significant curative effect.
Specifically prepare according to the following steps:
1. Herba Menthae 8～12 restrains, Flos Lonicerae 15～20 grams, and Radix Glycyrrhizae 5～10 grams, Galla Chinensis 10～15 grams boil 1-3 time through decocting, and each 2-3 hour, when the water extract is concentrated into proportion 1.2-1.4, high speed centrifugation;
2. centrifugal liquid or concentrate drying get crude extract;
3. macroporous resin through water elution, concentrates after the eluent decolouring, and with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Dosage form of the present invention is compared with existing membrane, monolayer patch, has following advantage:
1, this product has the adhesion layer that a side is a pastille; another layer is the characteristics of the double layer design of water-fast protective layer; can reduce dissolving and tablet the two-way adhesion gums and oral mucosa between of medicine, medicine is infiltrated and the sense of discomfort of minimizing in the oral cavity to ulcer surface to the offside of oral mucosa.
2, different with existing dosage form is that this product has the slow releasing function that reaches lasting release in 3-4 hour, can be positioned lesions position performance drug effect for a long time, alleviates the pain that ulcer is brought.Make the part that concentration higher, the long period be arranged and obtain curative effect preferably, thereby alleviate systemic side effects.
3, this dosage form confirms the mucosa nonirritant through the pharmacology zoopery, confirms through preliminary clinical experiment again, and the ulcer treatment rate can be up to more than 96%, and is evident in efficacy, is the novel form of present comparatively ideal treatment oral ulcer.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but not as limitation of the present invention.
Embodiment one
1. Herba Menthae 8 restrains, Flos Lonicerae 15 grams, and Radix Glycyrrhizae 5 grams, Galla Chinensis 10 grams boil 3 times through decocting, and each 2 hours, when the water extract is concentrated into proportion 1.2-1.4, high speed centrifugation; 2. centrifugal liquid or concentrate drying get crude extract; 3. macroporous resin through water elution, concentrates after the eluent decolouring, and with 95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Embodiment two
With Herba Menthae 12 grams, Flos Lonicerae 20 grams, Radix Glycyrrhizae 10 grams, Galla Chinensis 15 grams are used 75% alcohol reflux, extract 3 times, filtrate is condensed into extractum, adds water and makes extractum become suspension, through macroporous resin D301, water elution, eluent decolouring back concentrates, and with 95% ethanol precipitate with ethanol, refrigerator is placed, filter, filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Embodiment three
Herba Menthae 10 grams, Flos Lonicerae 150 grams, Radix Glycyrrhizae 8 grams, Galla Chinensis 15 grams, with Herba Menthae 10 grams, Flos Lonicerae 150 grams, Radix Glycyrrhizae 8 grams, Galla Chinensis 15 grams are used 95% alcohol reflux, extract 2 times, filtrate is condensed into extractum, adds water and makes extractum become suspension, through macroporous resin D301, water elution, eluent decolouring back concentrates, with 95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
Embodiment four
The double-deck oral cavity adhesion tablet (1000) of preparation Chinese medicine extract
Preparation technology:
Chinese medicine extract with recipe quantity, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose are crossed 100 mesh sieves respectively, abundant mixing, granulate through 30 mesh sieves, after 60 ℃ of oven dry, through 30 mesh sieve granulate, after adding the abundant mixing of carbopol, magnesium stearate, Pulvis Talci of 100 mesh sieves, with diameter 6mm flat punch tabletting promptly, every heavily about 40mg contains amlexanox 0.5mg.Ethyl cellulose 0.8g is dissolved with 95% alcohol 95 ml, add pigment 1mg, evenly be sprayed at the tablet surface, behind natural drying, form the protective layer of tablet with Membrane jetter.
According to the release in vitro situation of the double-deck oral cavity adhesion tablet of Chinese Pharmacopoeia 2000 editions drug release determination methods inspections Chinese medicine extract, the result is as follows:
The full release profiles of table 1 Chinese medicine extract oral cavity adhesion tablet
The result shows that the sustainable slow release medicine of this product is about 4 hours.
This paster sticks time average and reaches 3.6 hours (n=5) in the healthy volunteer oral cavity.
Embodiment two:
The double-deck oral cavity adhesion tablet (1000) of preparation Chinese medicine extract
Preparation technology:
Chinese medicine extract with recipe quantity, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose are crossed 100 mesh sieves respectively, abundant mixing, granulate through 30 mesh sieves, after 60 ℃ of oven dry, through 30 mesh sieve granulate, after adding the abundant mixing of carbopol, magnesium stearate, Pulvis Talci of 100 mesh sieves, with diameter 6mm flat punch tabletting promptly, every heavily about 42mg contains amlexanox 2mg.Ethyl cellulose 0.8 gram with 95% alcohol 95 ml dissolving, is added 1.5 milligrams of pigments, evenly be sprayed at the tablet surface, behind natural drying, form the protective layer of tablet with Membrane jetter.
Embodiment three:
The double-deck oral cavity adhesion tablet (1000) of preparation Chinese medicine extract
Preparation technology:
Chinese medicine extract with recipe quantity, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, sodium carboxymethyl cellulose are crossed 100 mesh sieves respectively, abundant mixing, granulate through 30 mesh sieves, after 60 ℃ of oven dry, through 30 mesh sieve granulate, after adding the abundant mixing of carbopol, magnesium stearate, Pulvis Talci of 100 mesh sieves, with diameter 6mm flat punch tabletting promptly, every heavily about 45mg contains amlexanox 5mg.Ethyl cellulose 0.8 gram with 95% alcohol 95 ml dissolving, is added pigment 2mg, evenly be sprayed at the tablet surface, behind natural drying, form the protective layer of tablet with Membrane jetter.
According to the release in vitro situation of the double-deck oral cavity adhesion tablet of Chinese Pharmacopoeia 2000 editions drug release determination methods inspections Chinese medicine extract, the result is as follows:
The full release profiles of table 3 Chinese medicine extract oral cavity adhesion tablet
The result shows that the sustainable slow release medicine of this product is about 4 hours.
This paster sticks time average and reaches 3.3 hours (n=5) in the healthy volunteer oral cavity.
Embodiment four:
The double-deck oral cavity adhesion tablet (2000) of preparation Chinese medicine extract
Preparation technology: with embodiment one.
Claims (5)
1. a Chinese medicine stomatocace double-layer paster is made up of the adhesion layer and the water-fast protective layer of pastille, and wherein the pastille adhesion layer contains Chinese medicine extract, carbopol, Borneolum Syntheticum, low-substituted hydroxypropyl cellulose, the sodium carboxymethyl cellulose of 0.1～15mg; Water-fast protective layer is made up of ethyl cellulose, food coloring; Chinese medicine extract wherein is by Herba Menthae 1.5～12 grams, and Flos Lonicerae 15～20 restrains, Radix Glycyrrhizae 5～10 grams, and Galla Chinensis 10～15 grams are formed.
2. Chinese medicine stomatocace double-layer paster as claimed in claim 1, Chinese medicine extract content wherein is 0.5～5mg.
3. Chinese medicine stomatocace double-layer paster as claimed in claim 1, Chinese medicine extract content wherein is 2-5mg.
4. Chinese medicine stomatocace double-layer paster as claimed in claim 1, wherein the adhesion layer of pastille contains Chinese medicine extract 5mg, carbopol 3mg, Borneolum Syntheticum 8.5mg, low-substituted hydroxypropyl cellulose 8mg, sodium carboxymethyl cellulose 17mg, magnesium stearate 0.2mg, Pulvis Talci 0.6mg; Water-fast protective layer contains ethyl cellulose 0.5～1.5mg, food coloring 1～2 μ g.
5. as the described Chinese medicine stomatocace double-layer paster of claim 1-4, being prepared as of Chinese medicine extract wherein: with Herba Menthae 1.5～12 grams, Flos Lonicerae 15～20 grams, Radix Glycyrrhizae 5～10 grams, Galla Chinensis 10～15 grams, use the 60-95% alcohol reflux, extract 2-3 time, filtrate is condensed into extractum, adding water makes extractum become suspension, through macroporous resin, water elution, eluent decolouring back concentrates, with 35%-95% ethanol precipitate with ethanol, refrigerator is placed, and filters, and filter cake vacuum drying, crushing screening or spray drying obtain off-white color fine-powdered extract.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526510A (en) * | 2012-02-06 | 2012-07-04 | 青岛农业大学 | Chinese composition for preventing and treating duck virus hepatitis |
| CN103751614A (en) * | 2014-01-12 | 2014-04-30 | 杨树国 | Traditional Chinese medicinal composition for treating radioactive oral mucositis |
| CN103908595A (en) * | 2014-04-02 | 2014-07-09 | 李志强 | Oral health lozenge and preparation method thereof |
| CN106974893A (en) * | 2017-04-14 | 2017-07-25 | 佛山市海科知识产权交易有限公司 | A kind of mouth ulcer paster and preparation method thereof |
| CN107260957A (en) * | 2017-06-25 | 2017-10-20 | 长沙善道新材料科技有限公司 | A kind of mouth ulcer paster and preparation method thereof |
-
2009
- 2009-11-05 CN CN2009100711962A patent/CN102048816A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526510A (en) * | 2012-02-06 | 2012-07-04 | 青岛农业大学 | Chinese composition for preventing and treating duck virus hepatitis |
| CN102526510B (en) * | 2012-02-06 | 2013-08-14 | 青岛农业大学 | Chinese composition for preventing and treating duck virus hepatitis |
| CN103751614A (en) * | 2014-01-12 | 2014-04-30 | 杨树国 | Traditional Chinese medicinal composition for treating radioactive oral mucositis |
| CN103908595A (en) * | 2014-04-02 | 2014-07-09 | 李志强 | Oral health lozenge and preparation method thereof |
| CN106974893A (en) * | 2017-04-14 | 2017-07-25 | 佛山市海科知识产权交易有限公司 | A kind of mouth ulcer paster and preparation method thereof |
| CN107260957A (en) * | 2017-06-25 | 2017-10-20 | 长沙善道新材料科技有限公司 | A kind of mouth ulcer paster and preparation method thereof |
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Application publication date: 20110511 |