CN103751614A - Traditional Chinese medicinal composition for treating radioactive oral mucositis - Google Patents
Traditional Chinese medicinal composition for treating radioactive oral mucositis Download PDFInfo
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- CN103751614A CN103751614A CN201410020767.0A CN201410020767A CN103751614A CN 103751614 A CN103751614 A CN 103751614A CN 201410020767 A CN201410020767 A CN 201410020767A CN 103751614 A CN103751614 A CN 103751614A
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating radioactive oral mucositis. Radioactive oral mucositis belongs to aphthous stomatitis in traditional Chinese medicine. Traditional Chinese medicinal materials with effects of invigorating qi and blood, clearing away heat and toxic materials, promoting salivation and moistening dryness, including Pedicularis rhinanthoides, Ventilago leiocarpa benth, Juglans cathayensis kernel, Blumea, Clerodendron fortunatum root, Aristolochia cathcartii, Thalictrum aquilegiifolium, Disporum calcaratum, seed of Foxtail Millet and Antidesma bunius, are made into decoction for mouthwash by patients. By clinical trials, the total effective rate is 96%, which is significantly superior to that of a control group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of radiotherapy oral mucositis.
Background technology
Radioactivity oral mucositis is a kind of complication occurring in the process of radiotherapy oral cavity and tumor of head and neck.Because therapeutic process inevitably merges radioreaction and damage, mucomembranous epithelial cell is more responsive to lonizing radiation, therefore inevitably causes radioactivity oral mucositis, to patient, brings very large misery.Chinese medicine Combined with Radiotherapy treatment tumor of head and neck has obvious synergism and attenuation.Chinese traditional treatment, adopts the mode of decocting soup rinsing the mouth, from pathology, starts with, and take blood yiqi, resolving heat and reducing pathogenic fire as Therapeutic Principle, pharmaceutical quantities is few and power is special, and rinsing the mouth again and again in addition, makes medicine directly act on focus part, and clinical effectiveness is remarkable.Doctor trained in Western medicine adopts these diseases for the treatment of such as antibiotic more, easily cause Drug resistance, and side effect is serious but take this type of medicine, and therapeutic effect is poor.Therefore adopt this disease of Chinese traditional treatment to have a clear superiority in.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of radiotherapy oral mucositis.Radioactivity oral mucositis should belong to the category of " erosion of the oral mucosa " in Chinese medicine.Chinese traditional treatment should invigorating qi and benefiting blood, heat-clearing and toxic substances removing, promote the production of body fluid and moisturize.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this radiotherapy oral mucositis is made by the Chinese medicine of following weight portion: Pedicularis rex C. B. Clarke ex Maxim. 20-25 part, Radix seu Caulis Verntilaginis Leiocarpae 15-25 part, Semen juglandis cathayensis 20-30 part, Herba Blumeae Lacerae 9-15 part, Radix Clerodendri Fortunati 9-15 part, Fructus Aristolochiae Kwangsiensis 1-3 part, Herba thalictri sibirici 3-9 part, Rhizoma Dispori Calcarati 10-15 part, foxtail millet seed 30-40 part, Radix seu Folium Antidesmae bunii 15-25 part.
Preferably, 23 parts of Pedicularis rex C. B. Clarke ex Maxim., 20 parts of Radix seu Caulis Verntilaginis Leiocarpae, 25 parts of Semen juglandis cathayensiss, 12 parts of Herba Blumeae Laceraes, 12 parts of Radix Clerodendri Fortunatis, 2 parts of Fructus Aristolochiae Kwangsiensiss, 6 parts of Herba thalictri sibirici, 13 parts of Rhizoma Dispori Calcaratis, 35 parts of foxtail millet seeds, 20 parts of Radix seu Folium Antidesmae buniis.
Preparation method is made decoction by above-mentioned Chinese medicine decocting.
In side: Pedicularis rex C. B. Clarke ex Maxim. benefiting vital QI and blood, invigorating spleen to remove dampness; Radix seu Caulis Verntilaginis Leiocarpae benefiting vital QI and blood, dispelling, collateral-activating; Semen juglandis cathayensis invigorating QI and blood, the beneficial gate of vitality, moistening the lung and resolving the phlegm; Herba Blumeae Lacerae heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Radix Clerodendri Fortunati heat-clearing and toxic substances removing, pain relieving removing heat from blood; Fructus Aristolochiae Kwangsiensis heat-clearing and toxic substances removing, expelling the stasis for the new, regulating QI to relieve pain; Herba thalictri sibirici heat-clearing and toxic substances removing, moistening lung and nourishing throat; Rhizoma Dispori Calcarati promoting the production of body fluid and benefiting QI, nourishing YIN and moistening the lung; The invigorating middle warmer of foxtail millet seed QI invigorating, dysphoria with smothery sensation are quenched one's thirst; May bitter edible plant promoting the production of body fluid to quench thirst, promoting blood circulation and detoxication.
Clinical data
1. the routine patient of physical data 50 all makes a definite diagnosis through cytology or histopathology, is all kinds of Malignant Tumor Cases of radiocurable incidence first, and at 29～80 years old age, function, electrocardiogram are all normal, without metastasis.Random packet, treatment group 25 examples, male 17 examples, female's 8 examples, 46.8 years old mean age.Matched group 25 examples, male 15 examples, female's 10 examples, 47.4 years old mean age.Two groups at aspects such as age, the course of disease, the state of an illness, sexes without significant difference (P>0.05), there is comparability.
2. diagnostic criteria: 1) accept radiotherapy medical history, have part or all of oral cavity to be included in radiation open country; 2) there is following symptoms: xerostomia, pharyngeal discomfort or pharyngalgia, hyperesthesia, feed difficulty etc.; 3) sign: saliva of buccal cavity reduces, mucosa is dry, congested, tunica albuginea formation, ulcer when serious.4) get rid of oral mucosa inflammation or the ulcer that other reason causes.
Therapeutic Method treatment group patient from radiotherapy start from the present invention selected Chinese medicine decocting soup rinsing the mouth, take Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Semen juglandis cathayensis 25g, Herba Blumeae Lacerae 12g, Radix Clerodendri Fortunati 12g, Fructus Aristolochiae Kwangsiensis 2g, Herba thalictri sibirici 6g, Rhizoma Dispori Calcarati 13g, foxtail millet seed 35g, Radix seu Folium Antidesmae bunii 20g, decocting is made decoction, each 25ml, every day buccal 5～8 times, under each 20 minutes posterior phraynxs of rinsing the mouth, after taking medicine, in half an hour, forbid drinking-water.Matched group patient uses compound recipe furacilin solution rinsing the mouth, until radiotherapy finishes.Two groups of radiotheraping methods, mode, dosage are basic identical.
4. criterion of therapeutical effect is effective: anergy mucous hyperemia, without pain, normal radiotherapy; Effective: the mucositis of spottiness shape, mild pain, normal radiotherapy; Invalid: lamellar mucositis accounts for irradiated region more than 50%, obviously pain, radiotherapy is interrupted.With obvious effective rate and effective percentage, calculate total effective rate.
5. two groups of patients of therapeutic outcome curative effect comparison after ten days, treatment group 25 examples, effective 13 examples (52%), effective 11 examples (44%), invalid 1 example (4%), total effective rate 96%; Matched group 25 examples, effective 4 examples (16%), effective 12 examples (48%), no effect 9 (36%), total effective rate 64%.Two groups of comparisons, treatment group cure rate, total effective rate are obviously better than matched group, have comparability (P<0.05).
The specific embodiment
Embodiment mono-: take Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Semen juglandis cathayensis 25g, Herba Blumeae Lacerae 12g, Radix Clerodendri Fortunati 12g, Fructus Aristolochiae Kwangsiensis 2g, Herba thalictri sibirici 6g, Rhizoma Dispori Calcarati 13g, foxtail millet seed 35g, May bitter edible plant 20g, above-mentioned Chinese medicine decocting is made to decoction.
Embodiment bis-: take Pedicularis rex C. B. Clarke ex Maxim. 25g, Radix seu Caulis Verntilaginis Leiocarpae 15g, Semen juglandis cathayensis 30g, Herba Blumeae Lacerae 9g, Radix Clerodendri Fortunati 15g, Fructus Aristolochiae Kwangsiensis 1g, Herba thalictri sibirici 9g, Rhizoma Dispori Calcarati 10g, foxtail millet seed 40g, Radix seu Folium Antidesmae bunii 15g, above-mentioned Chinese medicine decocting is made to decoction.
Embodiment tri-: take Pedicularis rex C. B. Clarke ex Maxim. 20g, Radix seu Caulis Verntilaginis Leiocarpae 25g, Semen juglandis cathayensis 20g, Herba Blumeae Lacerae 15g, Radix Clerodendri Fortunati 9g, Fructus Aristolochiae Kwangsiensis 3g, Herba thalictri sibirici 3g, Rhizoma Dispori Calcarati 15g, foxtail millet seed 30g, Radix seu Folium Antidesmae bunii 25g, above-mentioned Chinese medicine decocting is made to decoction.
Claims (2)
1. a Chinese medicine composition for radiotherapy oral mucositis, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Pedicularis rex C. B. Clarke ex Maxim. 20-25 part, Radix seu Caulis Verntilaginis Leiocarpae 15-25 part, Semen juglandis cathayensis 20-30 part, Herba Blumeae Lacerae 9-15 part, Radix Clerodendri Fortunati 9-15 part, Fructus Aristolochiae Kwangsiensis 1-3 part, Herba thalictri sibirici 3-9 part, Rhizoma Dispori Calcarati 10-15 part, foxtail millet seed 30-40 part, Radix seu Folium Antidesmae bunii 15-25 part.
2. the Chinese medicine composition of a kind of radiotherapy oral mucositis as claimed in claim 1, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 23 parts of Pedicularis rex C. B. Clarke ex Maxim., 20 parts of Radix seu Caulis Verntilaginis Leiocarpae, 25 parts of Semen juglandis cathayensiss, 12 parts of Herba Blumeae Laceraes, 12 parts of Radix Clerodendri Fortunatis, 2 parts of Fructus Aristolochiae Kwangsiensiss, 6 parts of Herba thalictri sibirici, 13 parts of Rhizoma Dispori Calcaratis, 35 parts of foxtail millet seeds, 20 parts of Radix seu Folium Antidesmae buniis.
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| CN201410020767.0A CN103751614A (en) | 2014-01-12 | 2014-01-12 | Traditional Chinese medicinal composition for treating radioactive oral mucositis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434890A (en) * | 2015-12-14 | 2016-03-30 | 孙绍娟 | Radiation stomatitis treating traditional Chinese medicine composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066298A (en) * | 2006-05-06 | 2007-11-07 | 杨志毅 | Chinese medicine powder for treating portacaval mucositis |
| CN101239119A (en) * | 2008-03-13 | 2008-08-13 | 张旭明 | Chinese herbal medicine oral liquid formulations for treating intractable oral ulcer and halitosis |
| CN102048816A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof |
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2014
- 2014-01-12 CN CN201410020767.0A patent/CN103751614A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066298A (en) * | 2006-05-06 | 2007-11-07 | 杨志毅 | Chinese medicine powder for treating portacaval mucositis |
| CN101239119A (en) * | 2008-03-13 | 2008-08-13 | 张旭明 | Chinese herbal medicine oral liquid formulations for treating intractable oral ulcer and halitosis |
| CN102048816A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434890A (en) * | 2015-12-14 | 2016-03-30 | 孙绍娟 | Radiation stomatitis treating traditional Chinese medicine composition |
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Application publication date: 20140430 |