CN105434890A - Radiation stomatitis treating traditional Chinese medicine composition - Google Patents
Radiation stomatitis treating traditional Chinese medicine composition Download PDFInfo
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- CN105434890A CN105434890A CN201510973670.6A CN201510973670A CN105434890A CN 105434890 A CN105434890 A CN 105434890A CN 201510973670 A CN201510973670 A CN 201510973670A CN 105434890 A CN105434890 A CN 105434890A
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 208000003265 stomatitis Diseases 0.000 title claims abstract description 9
- 230000005855 radiation Effects 0.000 title abstract 3
- 241000392039 Oreas martiana Species 0.000 claims abstract description 10
- 241001517368 Coelogyne Species 0.000 claims description 9
- 230000002285 radioactive effect Effects 0.000 claims description 9
- 241000196324 Embryophyta Species 0.000 abstract 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 235000015873 Antidesma dallachyanum Nutrition 0.000 abstract 1
- 244000159188 Antidesma dallachyanum Species 0.000 abstract 1
- 244000248539 Asparagus cochinchinensis Species 0.000 abstract 1
- 235000009292 Asparagus cochinchinensis Nutrition 0.000 abstract 1
- 241000723363 Clerodendrum Species 0.000 abstract 1
- 241000674039 Coelogyne occultata Species 0.000 abstract 1
- 241000723221 Crepis Species 0.000 abstract 1
- 241000026010 Dendrobium candidum Species 0.000 abstract 1
- 241000755641 Disporum Species 0.000 abstract 1
- 241001517310 Eria Species 0.000 abstract 1
- 240000003065 Malva verticillata Species 0.000 abstract 1
- 235000002384 Malva verticillata Nutrition 0.000 abstract 1
- 241000767839 Semiaquilegia adoxoides Species 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 8
- 208000005946 Xerostomia Diseases 0.000 description 7
- 206010013781 dry mouth Diseases 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 239000003440 toxic substance Substances 0.000 description 5
- 208000007117 Oral Ulcer Diseases 0.000 description 4
- 208000002399 aphthous stomatitis Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
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- 206010038743 Restlessness Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
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- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 231100000567 intoxicating Toxicity 0.000 description 1
- 230000002673 intoxicating effect Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000000693 radiobiological effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
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- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta (mosses)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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Abstract
The present invention discloses a radiation stomatitis treating traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicines. In clinical practice, according to the Chinese medicine theory, based on the cause of the radiation stomatitis, the traditional Chinese medicines such as radix scrophulariae, root of malva verticillata l, asparagus cochinchinensis, whole plant of oreas martiana (hopp. et hornsch.) brid, whole plant of dendrobium moniliforme(l.)sw, root and leaf of antidesma bunius (l.) spreng, herb of grassleaf eria, coelogyne occultata hook. f, crepis rigescens, root tuber of semiaquilegia adoxoides, rhizome of longspurred fairybells, and root or root bark of clerodendron fortunatum l are selected, decocting is performed with water to obtain a decoction, and the clinical trial results show that the total efficiency achieves 90%.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of herb mixture for the treatment of radioactive stomatitis.
Background technology
Radiotherapy is one of Main Means for the treatment of malignant tumor at present, and it is evident in efficacy, and the malignant tumor of about more than 70% need accept radiotherapy according to statistics.But in the treatment, tumor is controlled on the one hand; On the other hand, due to radiobiological effect, normal structure also correspondingly comes to harm, often cause again the toxic and side effects of some whole bodies or local, and Inflammation of Radioactive Oral Cavity is the one of its toxicity, main manifestations is xerostomia pharyngalgia, oral lesions, gingivitis, eating difficulties etc.Current doctor trained in Western medicine mainly relies on traditional therapy to be treated, and its curative effect is undesirable, easily produces drug resistance, and is not easily accepted by patient.I finds through clinical observation for many years, utilize treatment by Chinese herbs Inflammation of Radioactive Oral Cavity not only to have good curative effect, and toxic and side effects is little.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of radioactive stomatitis.The traditional Chinese medical science is thought: ionizing radiation is that kind of " hot " kills and wounds material, and heat can fire-transformation, and fire can burn Tianjin and drill into bright deficiency of YIN syndrome.Heat is fought mutually with cancer poison, and intoxicating heat is accumulate mutually, so the modal side reaction that is radiotherapy of the deficiency of YIN and pyretic toxicity.Chinese traditional treatment should YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treating radioactive stomatitis is made up of the Chinese medicine of following weight portion: Radix Scrophulariae 12-18 part, Radix Malvae 40-50 part, Radix Asparagi 10-16 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 15-21 part, Herba Dendrobii 12-16 part, Radix seu Folium Antidesmae bunii 20-30 part, Herba Eriae Graminifoliae 5-11 part, Herba Coelogynes 9-14 part, Radix Crepidis elongatae 20-30 part, Radix Semiaquilegiae 5-11 part, Rhizoma Dispori Calcarati 14-20 part, Radix Clerodendri Fortunati 12-20 part.
Preferred: Radix Scrophulariae 15 parts, Radix Malvae 45 parts, Radix Asparagi 13 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 parts, Herba Dendrobii 14 parts, May the bitter edible plant 25 parts, Herba Eriae Graminifoliae 8 parts, Herba Coelogynes 11 parts, Radix Crepidis elongatae 25 parts, Radix Semiaquilegiae 8 parts, Rhizoma Dispori Calcarati 17 parts, Radix Clerodendri Fortunati 16 parts.
Above-mentioned Chinese medicine is traditionally made decoction.
Fang Zhong: Radix Scrophulariae nourishing YIN to lower pathogenic fire, relieving restlessness removing toxic substances; Radix Malvae heat-clearing and toxic substances removing, sharp key is treating stranguria; Radix Asparagi is nourshing Yin and drynsessmoistening prescription, lung heat clearing pathogenic fire reducing; Oreas martiana (Hopp. Et Hornsch.) Brid. replenishing YIN and removing heat, tranquilizing the mind, expelling wind and removing dampness, hemostatic analgesia; Herba Dendrobii replenishing YIN and removing heat, strengthening the spleen and stomach; Radix seu Folium Antidesmae bunii promoting the production of body fluid to quench thirst, promoting blood circulation and detoxication; Herba Eriae Graminifoliae nourishing yin for benefiting stomach, born fluid; Herba Coelogynes tonifying-Yin and nourishing-stomach, promoting the production of body fluid to quench thirst, relieving restlessness; Radix Crepidis elongatae kidney-replenishing, replenishing QI and blood, strengthening the spleen and stomach; Radix Semiaquilegiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Rhizoma Dispori Calcarati nourishing YIN and moistening the lung, promoting the production of body fluid and benefiting QI; Radix Clerodendri Fortunati heat-clearing and toxic substances removing, cooling blood and relieving pain.
Clinical data
1. physical data accepts in JIUYUE, 2009 ~ 2012 Inflammation of Radioactive Oral Cavity patient 80 example in year August for medical treatment, wherein man 40 example, female 40 example; Age 22-67 year, average 48 years old; Be tumor of head and neck and accept radiotherapy patient, and have radioactivity oral cavity reaction in various degree.By being divided into treatment group 40 example at random, matched group 40 example.
2. Therapeutic Method treatment group adopts Chinese medicine composition of the present invention: take Radix Scrophulariae 15g, Radix Malvae 45g, Radix Asparagi 13g, Oreas martiana (Hopp. Et Hornsch.) Brid. 18g, Herba Dendrobii 14g, Radix seu Folium Antidesmae bunii 25g, Herba Eriae Graminifoliae 8g, Herba Coelogynes 11g, Radix Crepidis elongatae 25g, Radix Semiaquilegiae 8 parts, Rhizoma Dispori Calcarati 17g, Radix Clerodendri Fortunati 16g, traditionally make decoction, potion, divided and sooner or later took for twice every day.The matched group safe collutory of mouth, every day gargles for 3 times.
3. the reaction of observation index oral cavity is divided into I-III degree.I degree: only have xerostomia, can enter xerophagia; II degree: xerostomia is heavier, pharyngalgia, but without oral ulcer, enter xerophagia more difficult, can soft diet be entered; III degree: serious xerostomia, has oral ulcer, can only influent stream matter.
In addition, according to differential diagnosis in tcm, these patients show as scorchingly hot flourishing to some extent, the syndrome that cloudy Tianjin is impaired, as: restlessness and thirst, xerostomia halitosis, oral erosion, pharyngalgia, even the few tongue no fur of red tongue, or red tongue with yellow fur.
4, efficacy determination: oral ulcer heals, and xerostomia symptom is improved as healing, xerostomia pharyngalgia symptom is improved, and alleviates more than I degree for taking a turn for the better; Symptom is without improvement, or oral ulcer is invalid without healing.
5, before therapeutic outcome treatment, the reaction for the treatment of group oral cavity is 10 examples of I degree, II degree 21 example, III degree 9 example, 3 weeks post-evaluation curative effects: cure 18 examples, and take a turn for the better 18 examples, invalid 4 examples, effective percentage 90%.Before treatment, the reaction of matched group oral cavity is 10 examples of I degree, II degree 20 example, III degree 10 example.Cure 10 examples after treatment, take a turn for the better 15 examples, invalid 15 examples, effective percentage 62.5%.Through statistical test, two groups of comparitive study have significant difference P < 0.01, and treatment group is better than matched group.
Detailed description of the invention
Embodiment one: take Radix Scrophulariae 12g, Radix Malvae 40g, Radix Asparagi 10g, Oreas martiana (Hopp. Et Hornsch.) Brid. 15g, Herba Dendrobii 12g, Radix seu Folium Antidesmae bunii 20g, Herba Eriae Graminifoliae 5g, Herba Coelogynes 9g, Radix Crepidis elongatae 20g, Radix Semiaquilegiae 5g, Rhizoma Dispori Calcarati 14g, Radix Clerodendri Fortunati 12g, traditionally make decoction.
Embodiment two: take Radix Scrophulariae 15g, Radix Malvae 45g, Radix Asparagi 13g, Oreas martiana (Hopp. Et Hornsch.) Brid. 18g, Herba Dendrobii 14g, Radix seu Folium Antidesmae bunii 25g, Herba Eriae Graminifoliae 8g, Herba Coelogynes 11g, Radix Crepidis elongatae 25g, Radix Semiaquilegiae 8 parts, Rhizoma Dispori Calcarati 17g, Radix Clerodendri Fortunati 16g, traditionally make decoction.
Embodiment three: take Radix Scrophulariae 18g, Radix Malvae 50g, Radix Asparagi 16g, Oreas martiana (Hopp. Et Hornsch.) Brid. 21g, Herba Dendrobii 16g, Radix seu Folium Antidesmae bunii 30g, Herba Eriae Graminifoliae 11g, Herba Coelogynes 14g, Radix Crepidis elongatae 30g, Radix Semiaquilegiae 11g, Rhizoma Dispori Calcarati 20g, Radix Clerodendri Fortunati 20g, traditionally make decoction.
Claims (2)
1. a Chinese medicine composition for treating radioactive stomatitis, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Scrophulariae 12-18 part, Radix Malvae 40-50 part, Radix Asparagi 10-16 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 15-21 part, Herba Dendrobii 12-16 part, Radix seu Folium Antidesmae bunii 20-30 part, Herba Eriae Graminifoliae 5-11 part, Herba Coelogynes 9-14 part, Radix Crepidis elongatae 20-30 part, Radix Semiaquilegiae 5-11 part, Rhizoma Dispori Calcarati 14-20 part, Radix Clerodendri Fortunati 12-20 part.
2. the Chinese medicine composition of a kind for the treatment of radioactive stomatitis as claimed in claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: preferred: Radix Scrophulariae 15 parts, Radix Malvae 45 parts, Radix Asparagi 13 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 parts, Herba Dendrobii 14 parts, Radix seu Folium Antidesmae bunii 25 parts, Herba Eriae Graminifoliae 8 parts, Herba Coelogynes 11 parts, Radix Crepidis elongatae 25 parts, Radix Semiaquilegiae 8 parts, Rhizoma Dispori Calcarati 17 parts, Radix Clerodendri Fortunati 16 parts.
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Cited By (1)
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CN106581525A (en) * | 2017-01-17 | 2017-04-26 | 重庆市肿瘤研究所 | Throat-clearing mixture for treating radioactive stomatitis |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102210817A (en) * | 2011-05-10 | 2011-10-12 | 赵丽君 | Chinese medicine for treating radioactive stomatitis |
CN103751614A (en) * | 2014-01-12 | 2014-04-30 | 杨树国 | Traditional Chinese medicinal composition for treating radioactive oral mucositis |
CN104274706A (en) * | 2014-09-19 | 2015-01-14 | 魏文君 | Traditional Chinese medicine mixture for treating radioactive stomatitis |
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CN102210817A (en) * | 2011-05-10 | 2011-10-12 | 赵丽君 | Chinese medicine for treating radioactive stomatitis |
CN103751614A (en) * | 2014-01-12 | 2014-04-30 | 杨树国 | Traditional Chinese medicinal composition for treating radioactive oral mucositis |
CN104274706A (en) * | 2014-09-19 | 2015-01-14 | 魏文君 | Traditional Chinese medicine mixture for treating radioactive stomatitis |
Cited By (1)
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CN106581525A (en) * | 2017-01-17 | 2017-04-26 | 重庆市肿瘤研究所 | Throat-clearing mixture for treating radioactive stomatitis |
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Application publication date: 20160330 |