CN104337898A - Traditional Chinese medicine composition containing bunge cherry seeds for treating gout - Google Patents

Traditional Chinese medicine composition containing bunge cherry seeds for treating gout Download PDF

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CN104337898A
CN104337898A CN201410626089.2A CN201410626089A CN104337898A CN 104337898 A CN104337898 A CN 104337898A CN 201410626089 A CN201410626089 A CN 201410626089A CN 104337898 A CN104337898 A CN 104337898A
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chinese medicine
medicine composition
gout
traditional chinese
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CN104337898B (en
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彭超
张玲
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CHENGDU HUAXI TECHNOLOGY Co Ltd
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CHENGDU HUAXI TECHNOLOGY Co Ltd
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Abstract

The invention relates to a traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition containing bunge cherry seeds for treating gout, which belongs to the technical field of medicines. The traditional Chinese medicine composition for treating gout is prepared from the following medicinal raw materials in parts by weight: 4 to 20 parts of lycopodium clavatum, 3 to 15 parts of fructus choerospondiatis, 2 to 12 parts of dandelion, 2 to 11 parts of pennycress, 2 to 11 parts of apiary, 1 to 7 parts of bunge cherry seed and 1 to 7 parts of gynostemma pentaphylla. According to the traditional Chinese medicine composition for treating gout, after the seven medicinal raw materials are proportionally combined, the traditional Chinese medicine composition for treating gout has a synergy function and has an obvious curative effect on treating gout, and obvious side effects and untoward effects are not found.

Description

A kind of Chinese medicine composition of the treatment gout containing Semen Pruni
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of the treatment gout containing Semen Pruni, belong to medical art.
Background technology
Gout is also known as hyperuricemia, and sickness rate is high, healing is difficult, recurrent exerbation, belongs to the metabolic disease that disorders of purine metabolism causes.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, the gouty acute arthritis recurrent exerbation that its clinical characters is hyperuricemia and causes thus, tophaceous deposition, tophaceous chronic arthritis and joint deformity etc., dumb for main clinical manifestation with redness and swelling of joints, burning pain, recurrent exerbation, joint motion.Often involving kidney causes chronic interstitial nephritis and uric acid kidney stones to be formed.Increase reason according to uric acid in blood and can be divided into constitutional and the large class of Secondary cases two.The cause of disease of primary gout is caused by congenital purine metabolic disturbance, belongs to heritability.The cause of disease of secondary gout, can be caused by many reasons such as nephropathy, leukemia, medicine, foods, be apt to occur in male and menopausal woman.
The Western medicine being used for the treatment of gout at present mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only stablize the state of an illness mostly, gout can not be effected a radical cure; Serious side effect also can be caused to cause the infringement of hepatic and renal function; Even if Emergent therapy effectively can not recur by symptom management, and drug resistance and repellence can be produced, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes.
In Chinese medicine, gout belongs to " arthromyodynia " category, " treatise on blood trouble ": " gout, general numbness and hypoesthesia, limbs pain, modern name gout, Gu say arthromyodynia ".Increasing expert thinks, from the organic conception of the traditional Chinese medical science, treats with Chinese medicine integral syndrome differentiation, the good footpath of another bar for the treatment of gout of can yet be regarded as; Not only the toxic and side effects of Chinese medicine itself is little, and can reduce Western medicine dose, overcomes the huge toxic and side effects taken merely Western medicine for a long time and bring.
Summary of the invention
To the object of the invention is to overcome in prior art existing Western medicine side effect large, treat halfway above-mentioned deficiency, a kind of Chinese medicine composition of the treatment gout containing Semen Pruni is provided, this traditional Chinese medicine composition for treating gout good effect, instant effect, and little to patient body side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a Chinese medicine composition for the treatment gout of Semen Pruni, it is prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 4 ~ 20 parts, Fructus Choerospondiatis 3 ~ 15 parts, Herba Taraxaci 2 ~ 12 parts of, Herba Thlaspiss 2 ~ 11 parts, 2 ~ 11 parts, Nidus Vespae, Semen Pruni 1 ~ 7 part, Herb Gynostemmae Pentaphylli 1 ~ 7 part.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herba Lycopodii is 8 ~ 16 parts.Preferred, part by weight shared by Herba Lycopodii is 12 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Fructus Choerospondiatis is 5 ~ 12 parts.Preferred, part by weight shared by Fructus Choerospondiatis is 8 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herba Taraxaci is 4 ~ 9 parts.Preferred, part by weight shared by Herba Taraxaci is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, shared by ， Herba Thlaspis, part by weight is 4 ~ 9 parts.Shared by preferred ， Herba Thlaspis, part by weight is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Nidus Vespae is 4 ~ 8 parts.Preferred, part by weight shared by Nidus Vespae is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Semen Pruni is 2 ~ 5 parts.Preferred, part by weight shared by Semen Pruni is 3 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herb Gynostemmae Pentaphylli is 2 ~ 5 parts.Preferred, part by weight shared by Herb Gynostemmae Pentaphylli is 3 parts.
The Chinese medicine composition for the treatment of gout of the present invention, the active component of medicinal raw material can be extracted according to extracting method conventional on Chinese materia medica, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
The extracting method of Chinese medicine composition of the present invention can adopt but be not limited to following methods:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is condensed into extractum, dry, obtain the extract of medicinal raw material of the present invention.
(2) in above-mentioned extract, add pharmaceutic adjuvant and be mixed and made into acceptable various pharmaceutical dosage form on pharmaceutics.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of gout, be inventor based on the pathogenetic understanding of motherland's medical science to gout, according to oneself clinical experience for many years, first from numerous Chinese medicine, determine the effective Chinese medicine of a series for the treatment of gouts, repeatedly verify through clinical again, screen.Wherein, Herba Lycopodii, calls Lycopodium clavatum, lion tail, lion grass, green hair stretches muscle etc., is the dry herb of lycopsid Lycopodium clavatum; Mildly bitter flavor, pungent, warm in nature; Return liver,spleen,kidney warp; There is effect of expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral; For joint aches, the diseases such as joint stuffiness.Fructus Choerospondiatis is the dry mature fruit of Anacardiaceae plant Fructus Choerospondiatis; Sweet in the mouth, acid, property is put down; There is promoting flow of QI and blood, tranquilizing by nourishing the heart, resist myocardial ischemia and the effect such as cardiac function protecting, be mainly used in qi depression to blood stasis, the disease such as the thoracic obstruction is had a pain, shortness of breath and palpitation, irritability.Herba Taraxaci, another name Herba crotalariae albidae, Po Poding, feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herb of several plants together; Bitter, sweet, cold; Return liver, stomach warp; There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome; For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the diseases such as the puckery pain of pyretic stranguria.Herba Thlaspis, another name Herba Patriniae, Thalaspi arvense L.; For Cruciferae herba thlaspis genus plant Herba Thlaspis herb; Bitter in the mouth, sweet, property is put down; Return liver, kidney channel; There is heat-clearing and toxic substances removing, inducing diuresis and reducing edema, and the effect of middle appetizing; For appendicitis, lung abscess, carbuncle furuncle and phyma poison, erysipelas, endometritis, leucorrhea, nephritis, cirrhotic ascites, the diseases such as infantile dyspepsia.Nidus Vespae, Nidus Vespae, the nest etc. that another name Nidus Vespae, hornet's nest, Nidus Vespae, wild bee nest, hornet's nest, hundred are worn; For the nest of Vespidae insecticide fruit hornet, Japanese long foot wasp or different abdomen wasp; Sweet, flat; Return stomach warp; Have dispel the wind, merit poison, parasite killing, pain relieving effect; For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, the diseases such as fungal infection of hand and foot.Semen Pruni, another name semen pruni humilidis et japonicae, semen pruni tomentosae et trilobae; For the dry mature seed of rosaceous plant Prunus humilis (sour fourth, Xiao Li red), strongly fragrant Lee (red Fructus Pruni salicinae) or Prunus pedunculata Maxim.; Acrid in the mouth, hardship, sweet, property is put down; Return spleen, large intestine, small intestine meridian; Have and moisturize laxation, the therapeutic method to keep the adverse QI flowing downwards, effect of diuretic; For intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, edema, beriberi, the diseases such as dysuria.Herb Gynostemmae Pentaphylli, another name Herba Gynostemmatis, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, the root stock of cucurbitaceae genus gynostemma Herb Gynostemmae Pentaphylli; Hardship, cold; Return lung, spleen, kidney channel; There is effect of heat-clearing and toxic substances removing, eliminating phlegm and stopping cough; For chronic bronchitis, infectious hepatitis, nephritis, gastroenteritis.Above-mentioned 7 taste Chinese herbal medicine, flavour of a drug are few but function is complete, 7 taste medicinal raw materials are by after described proportioning combination, treatment gout has Synergistic function, and through clinical research test, Chinese medicine composition of the present invention is used for the treatment of gout short treating period, instant effect, administration is after 4 days, can take effect, and evident in efficacy, there is not obvious adverse reaction during patient consumes.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, and all technology realized based on content of the present invention all belong to scope of the present invention.
In embodiments of the invention and comparative example, ethanol used is the aqueous solution of ethanol, and the percentage composition of ethanol, if no special instructions, is volumn concentration.
Embodiment 1
The Chinese medicine composition of the treatment gout of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 12g, Fructus Choerospondiatis 8g, Herba Taraxaci 6g, Herba Thlaspis 6g, Nidus Vespae 6g, Semen Pruni 3g, Herb Gynostemmae Pentaphylli 3g.
The extracting method of above-mentioned medicinal raw material:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is concentrated into relative density 1.20 (80 DEG C), obtain the extract of embodiment 1 medicinal raw material.
(2) in above-mentioned extract, add the soluble starch of extract weight 2 times of weight, granulate, dry, be distributed into bag, obtain granule.
Embodiment 2
The Chinese medicine composition of the treatment gout of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 20g, Fructus Choerospondiatis 11g, Herba Taraxaci 2g, Herba Thlaspis 2g, Nidus Vespae 9g, Semen Pruni 1g, Herb Gynostemmae Pentaphylli 7g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 2 treats gout.
Embodiment 3
The Chinese medicine composition of the treatment gout of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 15g, Fructus Choerospondiatis 10g, Herba Taraxaci 8g, Herba Thlaspis 7g, Nidus Vespae 5g, Semen Pruni 4g, Herb Gynostemmae Pentaphylli 5g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 3 treats gout.
Comparative example
The Chinese medicine composition of the treatment gout of this comparative example is prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 12g, Fructus Choerospondiatis 8g, Herba Taraxaci 6g, Herba Thlaspis 6g, Nidus Vespae 6g, Herb Gynostemmae Pentaphylli 3g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition of comparative example treatment gout.
Pharmacodynamics and toxicity test:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to the Chinese medicine composition of embodiment 1 prepared by embodiment 1;
According to the Chinese medicine composition of comparative example prepared by comparative example;
Colchicine: be Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
2, test method and result
(1) on the impact of hyperuricemia Mouse Blood uric acid level
Get Kunming mouse 50, male and female are use all, and body weight 18 ~ 22g is divided into five groups at random, often organize 10, first group is normal saline group, and second group is drug study group of the present invention (8g raw medicinal herbs/kg), 3rd group is positive controls, and the 4th group is matched group 1, and the 5th group is model group.
Normal saline is gavaged by the dosage of 8g/kg to first group, second group gavages the Chinese medicine composition of the embodiment of the present invention 1 preparation by the dosage of 8g raw medicinal herbs/kg, 3rd group gavages colchicine by the drug dose of 0.1mg/kg, 4th group gavages Chinese medicine composition prepared by comparative example by the dosage of 8g raw medicinal herbs/kg, do not do any process for 5th group, every day 1 time, continuous 4 days.
After last administration 1h, except normal saline group, all the other each group, namely second group to the 5th group, animal Intraperitoneal injection of hypoxanthine 1mg/kg, causes mice hyperuricemia, and normal saline group presses 1mg/kg injecting normal saline.0.5h after injection, plucks eyeball to each treated animal and gets blood, and the blood obtained after centrifugal 15min, is got serum and surveyed Level of Serum Uric Acid under the speed conditions of 3000r/min.Table 1 be each experimental group and matched group after treatment, the statistical result of blood uric acid measured value.
Table 1
Note: compare with model group: *p<0.01; Compare with matched group 1: ▲ ▲p<0.01.
In table 1, it is 169 ± 36umol/l that drug study group of the present invention records Level of Serum Uric Acid: close with the Level of Serum Uric Acid 125 ± 26umol/l of normal saline group and the Level of Serum Uric Acid 146 ± 43umol/l of positive controls; Level of Serum Uric Acid 742 ± 104umol/l that relative model group records reduces about 570umol/l, and the statistical result of drug study group of the present invention is relative to model group P<0.01, has significant difference; The traditional Chinese medicine composition for treating gout that the present invention treats gout has good curative effect.
And in table 1, it is 232 ± 41umol/l that matched group 1 records Level of Serum Uric Acid, relative drug study group of the present invention records Level of Serum Uric Acid 169 ± 36umol/l and exceeds about 63umol/l.And the blood uric acid measured value of drug study group of the present invention is compared with the blood uric acid measured value P < 0.01 of matched group 1, has significant difference.Learn thus, 7 taste medicinal raw materials are by after described weight proportion combination, and have Synergistic function, can significantly improve the curative effect of Chinese medicine composition, lack any component, the curative effect of Chinese medicine composition all significantly declines.
In sum, the present invention treats the Chinese medicine composition of gout, and the short treating period for the treatment of gout, instant effect, administration can take effect for 4 days, evident in efficacy.Administration injected hypoxanthine after 4 days, and the blood uric acid measured value of drug study group of the present invention all can not occur significantly to raise phenomenon; 7 taste medicinal raw materials, by after described weight proportion combination, have Synergistic function, can significantly improve the curative effect of Chinese medicine composition.Lack any component, its curative effect all significantly declines, and as matched group 1, after injection hypoxanthine, the blood uric acid measured value recording the relative drug study group of the present invention of Level of Serum Uric Acid exceeds about 63umol/l.

Claims (10)

1., containing a Chinese medicine composition for the treatment gout of Semen Pruni, it is characterized in that: it is prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 4 ~ 20 parts, Fructus Choerospondiatis 3 ~ 15 parts, Herba Taraxaci 2 ~ 12 parts, Herba Thlaspis 2 ~ 11 parts, 2 ~ 11 parts, Nidus Vespae, Semen Pruni 1 ~ 7 part, Herb Gynostemmae Pentaphylli 1 ~ 7 part.
2. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Herba Lycopodii is 8 ~ 16 parts.
3. the Chinese medicine composition for the treatment of gout according to claim 2, is characterized in that: part by weight shared by Herba Lycopodii is 12 parts.
4. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Fructus Choerospondiatis is 5 ~ 12 parts.
5. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Herba Taraxaci is 4 ~ 9 parts.
6. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that part by weight shared by: Herba Thlaspis is 4 ~ 9 parts.
7. the Chinese medicine composition for the treatment of gout according to claim 6, is characterized in that part by weight shared by: Herba Thlaspis is 6 parts.
8. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Nidus Vespae is 4 ~ 8 parts.
9. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Semen Pruni is 2 ~ 5 parts.
10. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Herb Gynostemmae Pentaphylli is 2 ~ 5 parts.
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