CN104274706A

CN104274706A - Traditional Chinese medicine mixture for treating radioactive stomatitis

Info

Publication number: CN104274706A
Application number: CN201410513438.XA
Authority: CN
Inventors: 魏文君
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-19
Filing date: 2014-09-19
Publication date: 2015-01-14

Abstract

The invention discloses a traditional Chinese medicine mixture for treating radioactive stomatitis. The traditional Chinese medicine considers that the pathogenesis of the radioactive stomatitis refers to yin deficiency and heat toxins caused by ionization radiation. Therefore, the traditional Chinese medicines such as prepared salt, bornet cowlily rhizome, Dendrobium moniliforme, all-grass of dichotomous fimbristylis, antidesma bunius, grass-leaved eria, centaury, arcangelisia loureiri, buddhist bauhinia flower, tripair-leaved heynea root, Yunnan cowpea root and snake arrow back with the effects of nourishing yin and promoting the secretion of saliva or body fluid and clearing away heat and toxic materials are selected to be prepared into the mixture to be internally taken. The clinical test proves that the total effective rate is 82.50 percent, and the traditional Chinese medicine mixture does not have an obvious toxic or side effect.

Description

A kind of herb mixture for the treatment of radioactive stomatitis

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of herb mixture for the treatment of radioactive stomatitis.

Background technology

Radiotherapy is one of Main Means for the treatment of malignant tumor at present, and it is evident in efficacy, and the malignant tumor of about more than 70% need accept radiotherapy according to statistics.But in the treatment, tumor is controlled on the one hand; On the other hand, due to radiobiological effect, normal structure also correspondingly comes to harm, and often causes again the toxic and side effects of some whole bodies or local.Local response is in incidence, and main manifestations is xerostomia pharyngalgia, oral lesions, gingivitis, eating difficulties etc.I finds through clinical observation for many years, utilizes treatment by Chinese herbs Inflammation of Radioactive Oral Cavity to have good curative effect.

Summary of the invention

The object of this invention is to provide a kind of herb mixture for the treatment of radioactive stomatitis.The traditional Chinese medical science is thought, the few tongue of dry mouth and throat, red tongue belongs to that cloudy liquid is impaired, the syndrome of body fluid being damaged.Ionizing radiation is that kind of " hot " kills and wounds material, heat can fire-transformation, and fire can burn Tianjin and drill into bright deficiency of YIN syndrome.Heat and cancer poison are fought mutually, and intoxicating heat is accumulate mutually, so the deficiency of YIN and pyretic toxicity are radiotherapy (particularly incidence) modal side reactions.The local toxicity caused for radiotherapy, with YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing for primary treatment principle.

The object of the invention is to be achieved through the following technical solutions, the herb mixture of this treating radioactive stomatitis is made up of the Chinese medicine of following weight portion: Depositum urinae preparatum 3-9 part, Rhizoma Nupharis Bornetii 40-50 part, Herba Dendrobii 9-15 part, Radix Fimbristylis rigidulae 15-25 part, Radix seu Folium Antidesmae bunii 20-30 part, Herba Eriae Graminifoliae 9-15 part, Herba centaurll altaici 6-9 part, Caulis Arcangelisiae 20-30 part, Flos Bauhiniae Variegatae 9-15 part, Radix heyneae trijugae 15-20 part, Radix Vignae yunnanensis 9-15 part.

Preferred: Depositum urinae preparatum 6 parts, Rhizoma Nupharis Bornetii 45 parts, Herba Dendrobii 12 parts, Radix Fimbristylis rigidulae 20 parts, Radix seu Folium Antidesmae bunii 25 parts, Herba Eriae Graminifoliae 12 parts, Herba centaurll altaici 7.5 parts, Caulis Arcangelisiae 25 parts, Flos Bauhiniae Variegatae 12 parts, Radix heyneae trijugae 18 parts, Radix Vignae yunnanensis 12 parts.

Preparation method, by corresponding for above-mentioned Chinese medicine equal portions cold water soak 40min, soaks into rear decoction, and head decocts and boils rear slow fire with high heat and boil 30min, leaches medicinal liquid; Two decoct and add horizontal medicinal residues and decoct 20min, leach medicinal liquid; Three decoct and add horizontal medicinal residues and decoct 10min, leach medicinal liquid, three liquid medicine mixings.

Fang Zhong: Depositum urinae preparatum: nourishing YIN to lower pathogenic fire; Rhizoma Nupharis Bornetii: nourishing YIN and clearing away heat; Herba Dendrobii: yin nourishing, heat clearing away, strengthening the spleen and stomach; Radix Fimbristylis rigidulae: the beneficial damage of nourshing Yin and drynsessmoistening prescription, tonify deficiency; Radix seu Folium Antidesmae bunii: raw the moon quenches the thirst, promoting blood circulation and detoxication; Herba Eriae Graminifoliae: nourishing yin for benefiting stomach, born fluid; Herba centaurll altaici: heat-clearing and toxic substances removing; Caulis Arcangelisiae: heat-clearing and toxic substances removing; Flos Bauhiniae Variegatae: heat-clearing and toxic substances removing; Radix heyneae trijugae: heat-clearing and toxic substances removing, throat; Radix Vignae yunnanensis: heat-clearing and toxic substances removing, detumescence sore-throat relieving;

Clinical data

1. physical data accepts in JIUYUE, 2009 ~ 2011 Inflammation of Radioactive Oral Cavity patient 62 example in year April for medical treatment, wherein man 34 example, female 28 example; Age 21-68 year, average 48 years old; Be tumor of head and neck and accept radiotherapy patient, and have radioactivity oral cavity reaction in various degree.By random packet, be divided into treatment group 40 example (Chinese medicine plus radiotherapy), matched group 22 example (the safe collutory plus radiotherapy of mouth).

2. Therapeutic Method treatment group adopts new herb mixture: take Depositum urinae preparatum 6g, Rhizoma Nupharis Bornetii 45g, Herba Dendrobii 12g, Radix Fimbristylis rigidulae 20g, Radix seu Folium Antidesmae bunii 25g, Herba Eriae Graminifoliae 12g, Herba centaurll altaici 7.5g, Caulis Arcangelisiae 25g, Flos Bauhiniae Variegatae 12g, Radix heyneae trijugae 18g, Radix Vignae yunnanensis 12g, by corresponding equal portions medicine cold water soak 40min, soak into rear decoction, head decocts and boils rear slow fire with high heat and boil 30min, leaches medicinal liquid; Two decoct and add horizontal medicinal residues and decoct 20min, leach medicinal liquid; Three decoct and add horizontal medicinal residues and decoct 10min, leach medicinal liquid, three liquid medicine mixings.The matched group safe collutory of mouth, every day gargles for 3 times.

3. the reaction of observation index oral cavity is divided into I-III degree.I degree: only have xerostomia, can enter xerophagia; II degree: xerostomia is heavier, pharyngalgia, but without oral ulcer, enter xerophagia more difficult, can soft diet be entered; III degree: serious xerostomia, has oral ulcer, can only influent stream matter.

In addition, according to differential diagnosis in tcm, these patients show as scorchingly hot flourishing to some extent, the syndrome that cloudy Tianjin is impaired, as: restlessness and thirst, xerostomia halitosis, oral erosion, pharyngalgia, even the few tongue no fur of red tongue, or red tongue with yellow fur.

4, efficacy determination: oral ulcer heals, and xerostomia symptom is improved as healing, xerostomia pharyngalgia symptom is improved, and alleviates I degree, upper for taking a turn for the better; Symptom is without improvement, or oral ulcer is invalid without healing.

5, before therapeutic outcome treatment, the reaction for the treatment of group oral cavity is 7 examples of I degree, II degree 24 example, III degree 9 example, 3 weeks post-evaluation curative effects: cure 15 examples, and take a turn for the better 18 examples, invalid 7 examples, effective percentage 82.50%.Before treatment, the reaction of matched group oral cavity is 2 examples of I degree, II degree 15 example, III degree 5 example.Cure 1 example after treatment, take a turn for the better 9 examples, and invalid 12 examples, have digit rate 45.45%.Through statistical test, two groups of comparitive study have significant difference P < 0.01, and treatment group is better than matched group.

Detailed description of the invention

Embodiment one: take Depositum urinae preparatum 6g, Rhizoma Nupharis Bornetii 45g, Herba Dendrobii 12g, Radix Fimbristylis rigidulae 20g, Radix seu Folium Antidesmae bunii 25g, Herba Eriae Graminifoliae 12g, Herba centaurll altaici 7.5g, Caulis Arcangelisiae 25g, Flos Bauhiniae Variegatae 12g, Radix heyneae trijugae 18g, Radix Vignae yunnanensis 12g, Serpentis arrow back of the body 22.5g.By corresponding equal portions medicine cold water soak 40min, soak into rear decoction, head decocts and boils rear slow fire with high heat and boil 30min, leaches medicinal liquid; Two decoct and add horizontal medicinal residues and decoct 20min, leach medicinal liquid; Three decoct and add horizontal medicinal residues and decoct 10min, leach medicinal liquid, three liquid medicine mixings.

Embodiment two: take Depositum urinae preparatum 3g, Rhizoma Nupharis Bornetii 50g, Herba Dendrobii 9g, Radix Fimbristylis rigidulae 25g, Radix seu Folium Antidesmae bunii 20g, Herba Eriae Graminifoliae 9g, Herba centaurll altaici 6g, Caulis Arcangelisiae 30g, Flos Bauhiniae Variegatae 9g, Radix heyneae trijugae 20g, Radix Vignae yunnanensis 9g, Serpentis arrow back of the body 9g.By corresponding equal portions medicine cold water soak 40min, soak into rear decoction, head decocts and boils rear slow fire with high heat and boil 30min, leaches medicinal liquid; Two decoct and add horizontal medicinal residues and decoct 20min, leach medicinal liquid; Three decoct and add horizontal medicinal residues and decoct 10min, leach medicinal liquid, three liquid medicine mixings.

Embodiment three: take Depositum urinae preparatum 9g, Rhizoma Nupharis Bornetii 40g, Herba Dendrobii 15g, Radix Fimbristylis rigidulae 15g, Radix seu Folium Antidesmae bunii 30g, Herba Eriae Graminifoliae 15g, Herba centaurll altaici 9g, Caulis Arcangelisiae 20g, Flos Bauhiniae Variegatae 15g, Radix heyneae trijugae 15g, Radix Vignae yunnanensis 15g, Serpentis arrow back of the body 15g.By corresponding equal portions medicine cold water soak 40min, soak into rear decoction, head decocts and boils rear slow fire with high heat and boil 30min, leaches medicinal liquid; Two decoct and add horizontal medicinal residues and decoct 20min, leach medicinal liquid; Three decoct and add horizontal medicinal residues and decoct 10min, leach medicinal liquid, three liquid medicine mixings.

Claims

1. a herb mixture for treating radioactive stomatitis, is characterized in that this herb mixture is made up of the Chinese medicine of following weight portion: Depositum urinae preparatum 3-9 part, Rhizoma Nupharis Bornetii 40-50 part, Herba Dendrobii 9-15 part, Radix Fimbristylis rigidulae 15-25 part, Radix seu Folium Antidesmae bunii 20-30 part, Herba Eriae Graminifoliae 9-15 part, Herba centaurll altaici 6-9 part, Caulis Arcangelisiae 20-30 part, Flos Bauhiniae Variegatae 9-15 part, Radix heyneae trijugae 15-20 part, Radix Vignae yunnanensis 9-15 part.

2. the herb mixture of a kind for the treatment of radioactive stomatitis as claimed in claim 1, is characterized in that this herb mixture is made up of the Chinese medicine of following weight portion: Depositum urinae preparatum 6 parts, Rhizoma Nupharis Bornetii 45 parts, Herba Dendrobii 12 parts, Radix Fimbristylis rigidulae 20 parts, Radix seu Folium Antidesmae bunii 25 parts, Herba Eriae Graminifoliae 12 parts, Herba centaurll altaici 7.5 parts, Caulis Arcangelisiae 25 parts, Flos Bauhiniae Variegatae 12 parts, Radix heyneae trijugae 18 parts, Radix Vignae yunnanensis 12 parts.