CN104056177A - Traditional Chinese medicine composition for treating otitis media - Google Patents
Traditional Chinese medicine composition for treating otitis media Download PDFInfo
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- CN104056177A CN104056177A CN201410327253.XA CN201410327253A CN104056177A CN 104056177 A CN104056177 A CN 104056177A CN 201410327253 A CN201410327253 A CN 201410327253A CN 104056177 A CN104056177 A CN 104056177A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating otitis media, which relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: indigo naturalis, honeysuckle, semen raphani, ligusticum wallichii, cocklebur fruit, notopterygium root, rheum officinale, coix seeds, sweet osmanthus, rhizoma acori graminei, golden cypress, radix bupleuri, salvia miltiorrhiza, houttuynia cordata, bighead atractylodes rhizome, fructus amomi, radix angelicae, codonopsis pilosula, gallnut, cicada slough, poria, plantain herb, rhizoma alismatis and liquorice. The medicine is remarkable in anti-inflammatory and analgesic activity, remarkable in curative effect, safe and reliable, and wide in clinical application prospect.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of Chinese medicine composition and medical usage thereof for the treatment of otitis media.
Background technology
Otitis media is modal a kind of disease, cardinal symptom be suppurate, tinnitus and ear pain.Otitis media has multiple different pathogeny and symptom, and wherein acute and chronic catarrhal otitis media belongs to non-suppurative otitis media, and its symptom is: auditory dysesthesia, has deafness, tinnitus, in ear has current innervation while certainly listening enhancing, head movement.Instrument inspection is visible, otopiesis, and incorrect marking is clear, and limitation of activity has pharyngeal bone vessel dysfunction.Common cold, throat infection all can cause this disease, acutely easily controls chronic cannot radical cure.The conventional treatments of otitis media is exactly drug administration, and the traditional Chinese medical science thinks that kidney governing bones marrow has one's ideas straightened out in ear, should be main from yin nourishing removing heat from the heart to restore the consciousness, with dispelling wind and heat pathogens, and heat-clearing and detoxifying herb, with therapy of combining Chinese and Western medicine, effect is better.
At present, the otitis media Western medicine for the treatment of is more, but most drug therapeutic effect is poor, and also has the shortcomings such as treatment cost is higher, side effect is large, even affects patient health when serious.In addition, also have the Chinese medicine of a lot for the treatment of otitis media, but the shortcoming such as great majority have that therapeutic effect is poor, cure rate is low and treatment cycle is long.
CN1159935A discloses a kind of Powder medicine for otitis media, and it is formulated by Moschus, Borneolum Syntheticum, Camphora, Alumen, Herba Saxifragae, straw mushroom etc.Associate with medical herbs Herba Saxifragae, straw mushroom with Chinese medicine Moschus, ice reed etc., refinforce each other, promote curative effect.
CN1129131A discloses a kind of Medicinal powder for curing otitis media, in, Western medicine compatibility use, prescription is: Chinese Drug Rhizomes of Coptis, SD powder, SG powder, SB powder, natural biological alkali.
CN 1191118A discloses a kind of external pulvis of special treating acute and chronic otitis media, it forms by the Chinese medicine and western medicine such as Borneolum Syntheticum, Os Sepiae, antibiotics are refining, have heat-clearing and toxic substances removing, detumescence only bacterium, sterilizing and itch-relieving, absorption, convergence, fast in ear, and impel epithelial cell regeneration, tympanum reparation.
CN101537019A discloses a kind of medicine for the treatment of otitis media, and the formula composition of this medicine is made up of dried Alumen, Endoconcha Sepiae, Calomelas, Borneolum Syntheticum.
CN102475720A discloses a kind of medicine for the treatment of otitis media, and it is to be ground into powder by Concha Ostreae, these Chinese medicines of dried Alumen coordinating the actions of various ingredients in a prescription, evident in efficacy to treatment otitis media.
The technical problems such as have medicine costliness in prior art, patient tolerability is poor, and cure rate is low, therefore still need to treat the drug development of otitis media.
Summary of the invention
In order to make up the deficiencies in the prior art, it is evident in efficacy, safe and reliable to the invention provides a kind of Chinese medicine composition for the treatment of otitis media, has wide potential applicability in clinical practice.
Technical scheme of the present invention is:
A kind of Chinese medicine composition for the treatment of otitis media, this Chinese medicine composition is made up of the raw material of following weight portion: Indigo Naturalis 10-12 part, Flos Lonicerae 5-10 part, Semen Raphani 5-10 part, Rhizoma Chuanxiong 3-5 part, Fructus Xanthii 5-10 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Et Rhizoma Rhei 5-8 part, Semen Coicis 5-15 part, Flos Osmanthi Fragrantis 3-5 part, Rhizoma Acori Graminei 5-10 part, Cortex Phellodendri 3-5 part, Radix Bupleuri 5-10 part, Radix Salviae Miltiorrhizae 10-12 part, Herba Houttuyniae 5-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Fructus Amomi 6-9 part, Radix Angelicae Dahuricae 10-12 part, Radix Codonopsis 10-12 part, Galla Chinensis 12-15 part, Periostracum Cicadae 9-12 part, Poria 10-15 part, Herba Plantaginis 5-10 part, Rhizoma Alismatis 10-12 part, Radix Glycyrrhizae 15-10 part.
As a preferred embodiment in above-mentioned Chinese medicine composition, this Chinese medicine composition, its raw material by following weight portion is made: 10 parts of Indigo Naturaliss, 10 parts of Flos Loniceraes, 6 parts of Semen Raphanis, 3 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Xanthii, 10 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Et Rhizoma Rhei, 10 parts of Semen Coiciss, 5 parts of Flos Osmanthi Fragrantis, 5 parts of Rhizoma Acori Graminei, 3 parts of Cortex Phellodendris, 5 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Houttuyniae, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Fructus Amomis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 9 parts of Periostracum Cicadaes, 10 parts of Poria, 5 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 15 parts, Radix Glycyrrhizae.
In Chinese medicine composition described above, can also contain Rhizoma Zingiberis 5-8 part and Piper longum 12-15 part.This in two Chinese medicine can further strengthen the anti-inflammatory pain-stopping effect of the above-mentioned Chinese medicine composition of the present invention.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment otitis media medicine.Pharmaceutical composition of the present invention, in the time for the treatment of otitis media, demonstrates remarkable anti-inflammatory and antalgic activity.Drug effect demonstration of the present invention, it is long that mice licks the foot response latency.Chinese medicine composition of the present invention can extend mice to hot plate stimulate lick the sufficient response latency, have certain analgesic activity.Under same experiment condition, positive control drug hydrocortisone has also extended mice and has licked the incubation period that foot reacts, and have certain analgesic activity, but the analgesic effect of Chinese medicine composition of the present invention is more excellent.
In order to express better Chinese medicine composition of the present invention, Chinese medicine composition of the present invention can be prepared into conventional clinically dosage form.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention is prepared into powder, water preparation, tablet or capsule according to conventional preparation technology.
The present invention also provides a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned traditional Chinese medicine powder of recipe quantity and be broken into powder, doubly adding volumetric concentration according to the 4-10 of powder gross weight is the alcoholic solution of 40%-95%, reflux, extract, three times, each return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method, as tablet, capsule etc.
Pulverizing, backflow, the filtration of Chinese crude drug, be dried as this area common technology, breaking method and powder particle diameter are general knowledge well known to those skilled in the art, unless stated otherwise, otherwise are not particularly limited.
Inventor is through research repeatedly, progressively improve, the last medicine of successfully developing a kind of curative effect and treat preferably otitis media, for showing the therapeutic effect of medicine of the present invention to otitis media, the otitis media patient that the present invention takes this medicine to 180 examples has carried out clinical observation, and otitis media patient's 179 examples of selecting to have a comparability as a control group.Treatment group patient takes medicine twice of the present invention every day, sooner or later respectively once, once takes 5 grams of medicines, and matched group patient takes the oral drugs of conventional therapy otitis media.Treat after one month, therapeutic outcome is in table 1.
Table 1 treatment group and treatment of control group result synopsis
Treatment group is compared matched group and is had higher cure rate and effective percentage, thinks thus, and Drug therapy otitis media of the present invention has good effect, and observes through the treatment of month, takes medicine of the present invention and does not occur toxic and side effects.
Chinese medicine composition of the present invention, aspect otitis media, compared with prior art has following advantage:
1) medicine medicine of the present invention source is wide, is easy to get, cheap, is the ideal medicament for the treatment of otitis media.Untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, and medication effect is better, and has improved patient's quality of life.
2) in Chinese medicine composition of the present invention, contain multi-medicament component, action target spot is numerous, and pharmacological evaluation shows that itself and existing anti-inflammatory drug have significant synergism aspect treatment otitis media.
Detailed description of the invention
Further describe the present invention by specific embodiment below, but those skilled in the art should know, described embodiment does not also limit the present invention in any way.
(1) example of formulations part
Embodiment 1 Chinese medicine composition of the present invention and preparation technology
The weight portion of Chinese medicinal components: 10 parts of Indigo Naturaliss, 10 parts of Flos Loniceraes, 6 parts of Semen Raphanis, 3 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Xanthii, 10 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Et Rhizoma Rhei, 10 parts of Semen Coiciss, 5 parts of Flos Osmanthi Fragrantis, 5 parts of Rhizoma Acori Graminei, 3 parts of Cortex Phellodendris, 5 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Houttuyniae, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Fructus Amomis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 9 parts of Periostracum Cicadaes, 10 parts of Poria, 5 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 15 parts, Radix Glycyrrhizae.
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 90% alcoholic solution, reflux, extract, three times, and each return time is 2h, filters, filtrate recycling ethanol, obtains Chinese medical concrete after dry; Those skilled in the art can be in the technical conventional Chinese medicine pharmaceutical dosage forms clinically for preparing of this preparation method.
Embodiment 2 Chinese medicine composition of the present invention and preparation technology
The weight portion of Chinese medicinal components: 10 parts of Indigo Naturaliss, 5 parts of Flos Loniceraes, 5 parts of Semen Raphanis, 5 parts of Rhizoma Chuanxiongs, 5 parts of Fructus Xanthii, 15 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Radix Et Rhizoma Rhei, 5 parts of Semen Coiciss, 3 parts of Flos Osmanthi Fragrantis, 8 parts of Rhizoma Acori Graminei, 5 parts of Cortex Phellodendris, 6 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Herba Houttuyniae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts of Fructus Amomis, 12 parts of the Radixs Angelicae Dahuricae, 12 parts of Radix Codonopsis, 15 parts of Galla Chinensiss, 12 parts of Periostracum Cicadaes, 10 parts of Poria, 10 parts of Herba Plantaginiss, 12 parts of Rhizoma Alismatis, 12 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.Get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 10 times of coarse powder gross weight is 50% alcoholic solution, reflux, extract, three times, and each return time is 3h, filters, filtrate recycling ethanol, obtains Chinese medical concrete after dry; Those skilled in the art can be in the technical conventional Chinese medicine pharmaceutical dosage forms clinically for preparing of this preparation method.
Embodiment 3 Chinese medicine composition of the present invention and preparation technology
The weight portion of Chinese medicinal components: 12 parts of Indigo Naturaliss, 8 parts of Flos Loniceraes, 8 parts of Semen Raphanis, 5 parts of Rhizoma Chuanxiongs, 7 parts of Fructus Xanthii, 12 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Radix Et Rhizoma Rhei, 10 parts of Semen Coiciss, 5 parts of Flos Osmanthi Fragrantis, 10 parts of Rhizoma Acori Graminei, 3 parts of Cortex Phellodendris, 10 parts of Radix Bupleuri, 12 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Houttuyniae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Fructus Amomis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 9 parts of Periostracum Cicadaes, 10 parts of Poria, 5 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 10 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into powder, adding volumetric concentration according to 4 times of powder gross weight is 95% alcoholic solution, reflux, extract, three times, each return time is 2h, filters, filtrate recycling ethanol, obtains Chinese medical concrete after dry; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form capsule clinically for preparing of this preparation method.
Embodiment 4 Chinese medicine composition of the present invention and preparation technology
The weight portion of Chinese medicinal components: 13 parts of 10 parts of Indigo Naturaliss, 10 parts of Flos Loniceraes, 6 parts of Semen Raphanis, 3 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Xanthii, 10 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Et Rhizoma Rhei, 10 parts of Semen Coiciss, 5 parts of Flos Osmanthi Fragrantis, 5 parts of Rhizoma Acori Graminei, 3 parts of Cortex Phellodendris, 5 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Houttuyniae, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Fructus Amomis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 9 parts of Periostracum Cicadaes, 10 parts of Poria, 5 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 15 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 5, Piper longum.
Preparation method is with embodiment 1.
Embodiment 5 Chinese medicine composition of the present invention and preparation technology
The weight portion of Chinese medicinal components: 10 parts of Indigo Naturaliss, 5 parts of Flos Loniceraes, 8 parts of Semen Raphanis, 5 parts of Rhizoma Chuanxiongs, 8 parts of Fructus Xanthii, 12 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Et Rhizoma Rhei, 12 parts of Semen Coiciss, 3 parts of Flos Osmanthi Fragrantis, 5 parts of Rhizoma Acori Graminei, 5 parts of Cortex Phellodendris, 10 parts of Radix Bupleuri, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of Herba Houttuyniae, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts of Fructus Amomis, 12 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 9 parts of Periostracum Cicadaes, 10 parts of Poria, 7 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 10 parts, Radix Glycyrrhizae, 8 parts of Rhizoma Zingiberiss, Piper longum 12.
Preparation method is with embodiment 1.
Embodiment 6 Chinese medicine composition of the present invention and preparation technology
The weight portion of Chinese medicinal components: 12 parts of Indigo Naturaliss, 8 parts of Flos Loniceraes, 5 parts of Semen Raphanis, 3 parts of Rhizoma Chuanxiongs, 5 parts of Fructus Xanthii, 10 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Et Rhizoma Rhei, 5 parts of Semen Coiciss, 3 parts of Flos Osmanthi Fragrantis, 5 parts of Rhizoma Acori Graminei, 3 parts of Cortex Phellodendris, 10 parts of Radix Bupleuri, 12 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Houttuyniae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Fructus Amomis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 12 parts of Periostracum Cicadaes, 15 parts of Poria, 10 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 12 parts, Radix Glycyrrhizae, 6 parts of Rhizoma Zingiberiss, Piper longum 15.
Preparation method is with embodiment 1.
(2) drug effect embodiment part
The impact of embodiment 8 Chinese medicine composition of the present invention on mice hot-plate analgesia
1) mice hot plate pain model is made
Body weight 20g left and right female mice is placed on hot plate dolorimeter, screen 90 of qualified female mices and (lick metapedes time < 5 s or > 30 s throw aside, scald for preventing foot, also should establish deadline, be generally 60s), the incubation period of licking metapedes reaction taking mice is as threshold of pain index, get 72 jennies, be divided into 6 groups, 12/group, i.e. model group, hydrocortisone, Chinese medicine composition embodiment 1-6 of the present invention.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 2, and after successive administration 14d, after mensuration last medicine, 60 min, 120 min lick the time of foot reaction.
2) Chinese medicine composition of the present invention is on licking the impact of foot response latency in the experiment of mice hot-plate analgesia
Mice licks foot response latency time showing, with model group comparison, after administration after 1h and 2h, be all significantly greater than the incubation period that the mice of each administration group of Chinese medicine composition of the present invention licks foot reaction model group (
p< 0.05).Illustrate this Chinese medicine composition of the present invention can extend mice to hot plate stimulate lick the sufficient response latency, have certain analgesic activity.Under same experiment condition, positive control drug hydrocortisone group (
p< 0.05) also extend mice and licked the incubation period of foot reaction, there is certain analgesic activity, but its analgesic effect and model group there was no significant difference.The results are shown in Table 2.
Table 2 mice lick foot response latency timetable (
)
Note: with model group comparison, *
p< 0.05, * *
p< 0.01.
The antiinflammatory action of embodiment 7 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Hydrocortisone has stronger anti-inflammatory activity, that synthetic is also naturally occurring glucocorticoid, hydrocortisone enters after cell, activate cytoplasmic receptor, after allosteric, enter nucleus, be combined with DNA response element, cause inhibition or the induction of genetic transcription, the expression of inflammation associated protein is changed.
Experimental technique:
40 KM mices, male and female half and half, body weight 25-30 gram, be divided at random eight groups by body weight, i.e. dosage group in model control group, combination group high dose group, compositions, compositions low dose group, positive controls, every group 5, each administration group mice gives respectively following medicine:
Model control group: gavage gives the normal saline of same volume;
Positive controls: gavage gives the hydrocortisone drug solution of 5mg/kg;
Compositions group: gavage gives 50mg/kg embodiment 1 Chinese medicine composition Chinese medicine composition by crude drug amount.
Each administration group is administered once every day, successive administration 7d.After last administration, get dimethylbenzene 20 μ l, be applied to each mouse right ear.After 30 minutes, get and be respectively subject to reagent 0.03 ml to be evenly applied to respectively mouse right ear, auris dextra is put to death after 3.5 hours to dimethylbenzene, measures the each group of mice left and right ear method of double differences.Ear method of double differences assay method: place cuts two ears along auricle baseline, lays auricle with 8mm card punch at the same position of left and right ear, weighs, and the ear method of double differences=auris dextra sheet weight-left auricle weight.The ear method of double differences can be used as evaluates antiinflammatory index.
Experimental result:
Measure each experimental mice ear method of double differences and evaluate the antiphlogistic effects of each medication group medicine.Measurement result is in table 3.
The comparison of the each experimental mice ear of table 3 method of double differences
With model control group comparison,
* p< 0.05; With model control group comparison,
* p< 0.01;
With positive controls comparison,
# p< 0.05; With positive controls comparison,
## p< 0.01.
Result demonstration gives positive drug and Chinese medicine composition of the present invention all can be obtained significant antiphlogistic effects.
Claims (6)
1. treat the Chinese medicine composition of otitis media for one kind, it is characterized in that, its raw material by following weight portion is made: Indigo Naturalis 10-12 part, Flos Lonicerae 5-10 part, Semen Raphani 5-10 part, Rhizoma Chuanxiong 3-5 part, Fructus Xanthii 5-10 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Et Rhizoma Rhei 5-8 part, Semen Coicis 5-15 part, Flos Osmanthi Fragrantis 3-5 part, Rhizoma Acori Graminei 5-10 part, Cortex Phellodendri 3-5 part, Radix Bupleuri 5-10 part, Radix Salviae Miltiorrhizae 10-12 part, Herba Houttuyniae 5-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Fructus Amomi 6-9 part, Radix Angelicae Dahuricae 10-12 part, Radix Codonopsis 10-12 part, Galla Chinensis 12-15 part, Periostracum Cicadae 9-12 part, Poria 10-15 part, Herba Plantaginis 5-10 part, Rhizoma Alismatis 10-12 part, Radix Glycyrrhizae 10-15 part.
2. a kind of Chinese medicine composition for the treatment of otitis media as claimed in claim 1, it is characterized in that, its raw material by following weight portion is made: 10 parts of Indigo Naturaliss, 10 parts of Flos Loniceraes, 6 parts of Semen Raphanis, 3 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Xanthii, 10 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Et Rhizoma Rhei, 10 parts of Semen Coiciss, 5 parts of Flos Osmanthi Fragrantis, 5 parts of Rhizoma Acori Graminei, 3 parts of Cortex Phellodendris, 5 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Houttuyniae, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Fructus Amomis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Codonopsis, 12 parts of Galla Chinensiss, 9 parts of Periostracum Cicadaes, 10 parts of Poria, 5 parts of Herba Plantaginiss, 10 parts of Rhizoma Alismatis, 15 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of otitis media as claimed in claim 1, is characterized in that, described Chinese medicine composition also contains Rhizoma Zingiberis 5-8 part and Piper longum 12-15 part.
4. a kind of Chinese medicine composition for the treatment of otitis media as described in claim 1,2 or 3, is characterized in that described Chinese medicine composition is powder, water preparation, tablet or capsule.
5. as described in claim 1,2 or 3, treat the preparation method of the Chinese medicine composition of otitis media for one kind, it is characterized in that comprising following step: get Chinese crude drug and be broken into powder, doubly adding volumetric concentration according to the 4-10 of powder gross weight is the alcoholic solution of 40%-95%, each reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete.
6. the treatment otitis media Chinese medicine composition as described in claim 1,2 or 3 is treated the purposes in otitis media medicine in preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815293A (en) * | 2015-05-26 | 2015-08-05 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine tablet for treating otitis media and preparation method thereof |
| CN105833119A (en) * | 2016-05-24 | 2016-08-10 | 柳晖 | Traditional Chinese medicine composition for treating tympanitis |
| CN106853003A (en) * | 2016-11-10 | 2017-06-16 | 李蕊 | It is a kind of to treat pharmaceutical composition of tympanitis and preparation method thereof |
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| CN101028459A (en) * | 2007-04-02 | 2007-09-05 | 王爱华 | Oral Chinese-medical composition for treating chronic otitis media |
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| CN101028459A (en) * | 2007-04-02 | 2007-09-05 | 王爱华 | Oral Chinese-medical composition for treating chronic otitis media |
Non-Patent Citations (1)
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| 王丽丽: "中医药治疗分泌性中耳炎进展研究", 《中医耳鼻喉科学研究杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815293A (en) * | 2015-05-26 | 2015-08-05 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine tablet for treating otitis media and preparation method thereof |
| CN105833119A (en) * | 2016-05-24 | 2016-08-10 | 柳晖 | Traditional Chinese medicine composition for treating tympanitis |
| CN106853003A (en) * | 2016-11-10 | 2017-06-16 | 李蕊 | It is a kind of to treat pharmaceutical composition of tympanitis and preparation method thereof |
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Application publication date: 20140924 |