CN107260957A - A kind of mouth ulcer paster and preparation method thereof - Google Patents
A kind of mouth ulcer paster and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
Abstract
The present invention relates to technical field of Chinese patent medicine, a kind of mouth ulcer paster and preparation method thereof is disclosed.The mouth ulcer paster includes the raw material of following parts by weight：58 parts of 15 25 parts of Notogineng Extract, 10 20 parts of American ginseng extract, 5 15 parts of Honegsukle flower P.E, 5 15 parts of Radix Sangusorbae extract, 26 parts of bletilla striata extract, 37 parts of Baical Skullcap root P.E, 13 parts of snake oil, 35 parts of borneol, 26 parts of oyster shell whiting base quick-dissolving agent, 13 parts of lubricant, 24 parts of sodium carboxymethylcellulose, 8 18 parts of forming agent, 13 parts of adhesive, 13 parts of coating agent, 37 parts of chitosan, 14 parts of polyvinyl alcohol and sodium carboxymethyl starch.Active constituent content is high in the mouth ulcer paster of the present invention, and its dissolution efficiency in oral environment is high, easily absorbs, therefore drug effect is rapid-action, and therapeutic effect is good.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, more particularly to a kind of mouth ulcer paster and preparation method thereof.
Background technology
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in
The positions such as lip inner side, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, the mucous membrane at these positions lack keratinization layer or angling compared with
Difference.Tongue ulcer, which refers to, betides tongue, the canker sore of tongue belly position.Sharp ache when canker sore is broken out, local cusalgia is bright
Aobvious, severe patient can also influence diet, speak, and very big inconvenience is caused to daily life；Can concurrently halitosis, chronic pharyngitis, constipation, head
The constitutional symptoms such as bitterly, dizzy, nauseous, weak, irritated, heating, enlargement of lymph nodes.
Application No. CN200910071196.2 patent discloses a kind of Chinese medicinal double-layer patch for treating oral ulcer, wherein pastille
Adhesion layer contains 0.1~15mg Chinese medical extract, carbopol, borneol, low-substituted hydroxypropyl cellulose, carboxymethyl cellulose
Sodium；Water insoluble protective layer is made up of ethyl cellulose, food coloring；Chinese medical extract therein is by 8~12 grams of peppermint, gold
15~20 grams of honeysuckle flower, 5~10 grams of radix glycyrrhizae, 10~15 grams of compositions of Chinese gall.The double-layer paster medicine that the present invention is provided can fully change
Kind topical ulcers tissue, repairs recovery from illness, to reach the purpose for the treatment of, this Chinese patent drug is nontoxic to human body, without decoction early,
It is convenient to take.Treat both principal and secondary aspect of disease, clinical efficacy is significantly, efficient up to 96%.
Application No. CN200910228276.4 patent disclose a kind of Oralease Chinese medicine patch, sticking tablet and
Its preparation method.The paster includes two layers of medicated layer and separation layer.Medicated layer includes mucosal ulcer Chinese medicine, adhesion material etc..Every
Absciss layer includes water proof material etc., and wherein weight ratio of the Chinese medicine in medicated layer is 10-60%.Double-decker prepared by the present invention
Oral mucosa ulcer sticking tablet, it is accurate with drug dose, it is affixed directly on oral ulcer surface, fixed ulcer surface mitigates pain
Bitterly, it can keep with ulcerated mucosa longer time of contact, the characteristics of giving full play to drug effect, while medicine can be avoided to be migrated in oral cavity
The sense of discomfort brought to patient.Drug therapy canker sore of the present invention is efficient up to 98%, and cure rate is up to 90%.
Said medicine exist defect be directly by each taste Chinese medicine milling be mixed to prepare, on the one hand, ingredients without
Extraction is crossed, causes active constituent content in medicinal material relatively low, drug effect is have impact on to a certain extent.On the other hand, due to without carrying
Take, the medicine of topical class is not easy to dissolution in the oral cavity, be difficult to absorb.Cause action slower.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides a kind of mouth ulcer paster and preparation method thereof.The present invention
Mouth ulcer paster in active constituent content it is high, and its dissolution efficiency in oral environment is high, easily absorbs, therefore drug effect
Rapid-action, therapeutic effect is good.
The present invention concrete technical scheme be：A kind of mouth ulcer paster, includes the raw material of following parts by weight：Pseudo-ginseng is extracted
15-25 parts of thing, 10-20 parts of American ginseng extract, 5-15 parts of Honegsukle flower P.E, 5-15 parts of Radix Sangusorbae extract, bletilla striata extract
2-6 parts, 3-7 parts of Baical Skullcap root P.E, 1-3 parts of snake oil, 3-5 parts of borneol, 2-6 parts of oyster shell whiting base quick-dissolving agent, 1-3 parts of lubricant, carboxylic
1-3 parts of 2-4 parts of sodium carboxymethylcellulose pyce, 8-18 parts of forming agent, 1-3 parts of adhesive and coating agent, 3-7 parts of chitosan, polyvinyl alcohol
1-4 parts and 5-8 parts of sodium carboxymethyl starch.
Main ingredient composition of the invention includes Notogineng Extract, American ginseng extract, Honegsukle flower P.E, garden burnet extraction first
Thing, bletilla striata extract, Baical Skullcap root P.E, snake oil, borneol, carboxymethyl chitosan.Wherein Notogineng Extract, American ginseng extract,
Honegsukle flower P.E, Radix Sangusorbae extract, Baical Skullcap root P.E, borneol have effects that purging intense heat, clearing heat and detoxicating, swelling and pain relieving, the bletilla striata
With astringing to arrest bleeding, detumescence and promoting granulation, the effect for promoting ulcer part tissue repair.Snake oil has stronger infiltration to mucous membrane of mouth
Property, feeling cool after being fitted with mucous membrane of mouth is pleasant, can moisten mucous membrane of mouth, promote mucous membrane of mouth reparation.And the bletilla striata and shell
Glycan is more affine with skin, can further improve drug effect, promotion organization reparation in oral mucosal surface film forming.Carboxymethyl
Chitosan also has bactericidal action, prevents superinfection., can be quick for treatment canker sore after above-mentioned each herbal medicine coordinates
Effectively.Also, it is invalid due to reducing compared with the medicine that those directly just add traditional Chinese medicinal material raw materials without purifying with other
Impurity component so that the content of composition active drug composition is higher.
In addition, the chitosan in the present invention has the advantages that preferable biocompatibility and biodegradable, it can promote
The healing of canker sore, there play the role of to the treatment of ulcer to be special；Polyvinyl alcohol (PVA) is the water with good biocompatibility
Gel-like biomaterial, is used as one of active ingredient of film forming agent.Sodium carboxymethyl starch can improve the fusing time of film, with good
Good film forming and viscosity, makes it have good air penetrability and imbibition, this is for patch absorption wound fluid and ulcer
The protection in face is very favourable.Inventor is by a large amount of it was verified that paster made from these three raw materials is added, with good
Pliability, imbibition and airing function, are the optimal selections of canker sore surface of a wound covering patch material.
Secondly, the present invention for after medicine use in the prior art in the specific environment of oral cavity active ingredient rate of dissolution compared with
Slowly, be difficult absorb technical problem, employ oyster shell whiting base quick-dissolving agent so that medicine in oral environment can Fast Stripping,
In favor of absorption in time.There is preferably viscosity after sodium carboxymethylcellulose moisture absorption, paster can be helped to be bonded with cavity mucous membrane.
Preferably, the forming agent includes 2-6 parts of 6-12 parts of carbomer and propolis.Carbomer and propolis can make paster into
Type, and bonded after docile with mucous membrane of mouth.
Preferably, the coating agent is selected from acrylic resin II or acrylic resin III.
Further, the oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate.
Further, the preparation method of the oyster shell whiting base quick-dissolving agent is as follows：Oyster shell whiting is cleaned, first at 300-400 DEG C
Lower calcining 0.5-1.5h, is ground to 100-200 mesh after cooling, continue to calcine 2-4h at 600-800 DEG C after cleaning；Ground after cooling
400-800 mesh is milled to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to it
It is uniformly dispersed in the sodium alginate of 0.5-1.0 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
The present invention oyster shell whiting base quick-dissolving agent in, major matrix material for calcining after oyster shell whiting, and its surface by
Sodium alginate is coated.In its preparation process, first to oyster shell whiting step calcination under the above specified conditions, in the first step, first
The biological organic matter adhered in shell is removed；In second step, the main component of oyster shell whiting is calcium carbonate, and calcium carbonate is by high temperature
Calcining and decomposing is calcium oxide and carbon dioxide, then is crushed as compared with little particulate.After the calcining of above-mentioned two steps specified conditions, by
In the removal and the disengaging of carbon dioxide of organic matter, the nanometer, micron-sized largely communicated can be produced on shell matrix
Micropore so that it has larger specific surface area, so that with outstanding adsorptivity and reactivity.Shell after thus calcining
Powder has extremely strong adsorptivity and respond for water.And certain heat can be produced after its moisture absorption reaction, so that plus
The dissolution of active ingredient in fast medicine.And sodium alginate also have outstanding hygroscopicity, after its moisture absorption have stickiness, easily into
Film, is coated on behind oyster shell whiting surface, on the one hand can absorb Environmental Water and pass it to oyster shell whiting, be transmitted as moisture
Intermediary；On the other hand because oyster shell whiting moisture absorption heat release may have a certain impact to mucous membrane of mouth tool, cause human body uncomfortable,
Therefore sodium alginate coats oyster shell whiting, can avoid its directly with a large amount of water haptoreactions and amount of heat；And after reaction
Due to the isolation of sodium alginate, moment is not transferred to outside to heat, and security is higher.
Preferably, the lubricant is selected from magnesium stearate, talcum powder, superfine silica gel powder or stearic acid.
Preferably, described adhesive is ethanol.Ethanol not only has preferable wetting action to various raw materials, and will not
So that the material easily absorbed water in raw material in preparation process with regard to dissolving.
The preparation method of above-mentioned mouth ulcer paster, comprises the following steps：
(1) each raw material is weighed by proportioning.
(2) by Notogineng Extract, American ginseng extract, Honegsukle flower P.E, Radix Sangusorbae extract, bletilla striata extract, radix scutellariae
Extract, borneol, chitosan, oyster shell whiting base quick-dissolving agent, sodium carboxymethylcellulose are well mixed, and are subsequently added into snake oil mixing equal
It is even.
(3) it is the compound of step (2) and forming agent, mix lubricant is uniform, after being soaked with adhesive, carry out tabletting.
(4) it is coated after tabletting with coating agent, mouth ulcer paster is made after drying.
The invention has the advantages that：Active constituent content is high in mouth ulcer paster of the present invention, and it is disappearing
Change dissolution efficiency in road environment high, easily absorb, therefore good drug efficacy.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1
A kind of mouth ulcer paster, includes the raw material of following parts by weight：20 parts of Notogineng Extract, American ginseng extract 15
Part, 10 parts of Honegsukle flower P.E, 10 parts of Radix Sangusorbae extract, 4 parts of bletilla striata extract, 5 parts of Baical Skullcap root P.E, 2 parts of snake oil, borneol 4
Part, the bonding of 4 parts of oyster shell whiting base quick-dissolving agent, 2 parts of magnesium stearate, 3 parts of sodium carboxymethylcellulose, 9 parts of carbomer, 4 parts of propolis, ethanol
8 parts of 2 parts of agent, 2 parts of acrylic resin III, 3 parts of chitosan, 4 parts of polyvinyl alcohol and sodium carboxymethyl starch.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 380 DEG C and 100-200 mesh is ground to after 1h, cooling, continue to calcine 3h at 700 DEG C after cleaning；Ground after cooling
400-800 mesh is milled to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, by calcined shell powder be added to its 0.7
It is uniformly dispersed in the sodium alginate of times quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 2
A kind of mouth ulcer paster, includes the raw material of following parts by weight：15 parts of Notogineng Extract, American ginseng extract 20
Part, 5 parts of Honegsukle flower P.E, 15 parts of Radix Sangusorbae extract, 2 parts of bletilla striata extract, 7 parts of Baical Skullcap root P.E, 1 part of snake oil, borneol 5
Part, 6 parts of oyster shell whiting base quick-dissolving agent, 1 part of talcum powder, 4 parts of sodium carboxymethylcellulose, 6 parts of carbomer, 6 parts of propolis, ethanol adhesive
5 parts of 2 parts, 3 parts of acrylic resin II, 7 parts of chitosan, 1 part of polyvinyl alcohol and sodium carboxymethyl starch.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 300 DEG C and 100-200 mesh is ground to after 1.5h, cooling, continue to calcine 4h at 600 DEG C after cleaning；After cooling
400-800 mesh is ground to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to it
It is uniformly dispersed in the sodium alginate of 1.0 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 3
A kind of mouth ulcer paster, includes the raw material of following parts by weight：25 parts of Notogineng Extract, American ginseng extract 10
Part, 15 parts of Honegsukle flower P.E, 5 parts of Radix Sangusorbae extract, 6 parts of bletilla striata extract, 3 parts of Baical Skullcap root P.E, 3 parts of snake oil, borneol 3
Part, 2 parts of oyster shell whiting base quick-dissolving agent, 3 parts of superfine silica gel powder, 2 parts of sodium carboxymethylcellulose, 12 parts of carbomer, 2 parts of propolis, ethanol glue
6 parts of 2 parts of mixture, 1 part of acrylic resin III, 4 parts of chitosan, 2 parts of polyvinyl alcohol and sodium carboxymethyl starch.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 350 DEG C and 100-200 mesh is ground to after 1h, cooling, continue to calcine 3.5h at 650 DEG C after cleaning；After cooling
400-800 mesh is ground to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to it
It is uniformly dispersed in the sodium alginate of 0.8 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 4
A kind of preparation method of mouth ulcer paster, comprises the following steps：
(1) each raw material is weighed by proportioning
(2) by Notogineng Extract, American ginseng extract, Honegsukle flower P.E, Radix Sangusorbae extract, bletilla striata extract, radix scutellariae
Extract, borneol, chitosan, oyster shell whiting base quick-dissolving agent, sodium carboxymethylcellulose are well mixed, and are subsequently added into snake oil mixing equal
It is even.
(3) it is the compound of step (2) and forming agent, mix lubricant is uniform, after being soaked with adhesive, carry out tabletting.
(4) it is coated after tabletting with coating agent, mouth ulcer paster is made after drying.
Comparative example 1
A kind of mouth ulcer paster, includes the raw material of following parts by weight：20 parts of Notogineng Extract, American ginseng extract 15
Part, 10 parts of Honegsukle flower P.E, 10 parts of Radix Sangusorbae extract, 4 parts of bletilla striata extract, 5 parts of Baical Skullcap root P.E, 2 parts of snake oil, borneol 4
Part, 4 parts of chitosan, 2 parts of magnesium stearate, 3 parts of sodium carboxymethylcellulose, 11 parts of carbomer, 6 parts of propolis, 2 parts of ethanol adhesive and
2 parts of acrylic resin III.
Comparative example 2
A kind of mouth ulcer paster, includes the raw material of following parts by weight：15 parts of Notogineng Extract, American ginseng extract 20
Part, 5 parts of Honegsukle flower P.E, 15 parts of Radix Sangusorbae extract, 2 parts of bletilla striata extract, 7 parts of Baical Skullcap root P.E,
1 part of snake oil, 5 parts of borneol, 2 parts of chitosan, 1 part of talcum powder, 4 parts of sodium carboxymethylcellulose, 9 parts of carbomer, propolis 9
3 parts of part, 2 parts of ethanol adhesive and acrylic resin II.
Embodiment 1-3 and comparative example 1-2 mouth ulcer paster is carried out active ingredient (choose Notogineng Extract and
American ginseng extract, which is used as, represents detection composition) dissolution rate tested, and test condition is as follows, by 2g mouth ulcer paster
(area is 0.5cm2) throw in the water that 20mL temperature is 38 ± 0.5 DEG C, it is effective respectively at 1min, 5min and 10min detection
Composition dissolution rate, it is as a result as follows：
By data comparison, in embodiment 1-3 the dissolution efficiency of effective ingredient apparently higher than comparative example 1-2,
Dissolution rate particularly in 5min, lifting is notable, and if fully absorbed medicine in 5min, is more beneficial for working,
Therapeutic effect is more preferable.
Raw materials used in the present invention, equipment, is the conventional raw material, equipment of this area unless otherwise noted；In the present invention
Method therefor, is the conventional method of this area unless otherwise noted.
It is described above, only it is presently preferred embodiments of the present invention, not the present invention is imposed any restrictions, it is every according to the present invention
Any simple modification, change and equivalent transformation that technical spirit is made to above example, still fall within the technology of the present invention side
The protection domain of case.
Claims (8)
1. a kind of mouth ulcer paster, it is characterised in that include the raw material of following parts by weight：15-25 parts of Notogineng Extract, the West
10-20 parts of conopsea extraction, 5-15 parts of Honegsukle flower P.E, 5-15 parts of Radix Sangusorbae extract, 2-6 parts of bletilla striata extract, radix scutellariae are extracted
3-7 parts of thing, 1-3 parts of snake oil, 3-5 parts of borneol, 2-6 parts of oyster shell whiting base quick-dissolving agent, 1-3 parts of lubricant, sodium carboxymethylcellulose 2-4
Part, 8-18 parts of forming agent, 1-3 parts of adhesive, 1-3 parts of coating agent, 3-7 parts of chitosan, 1-4 parts of polyvinyl alcohol and CMS
5-8 parts of sodium.
2. a kind of mouth ulcer paster as claimed in claim 1, it is characterised in that the forming agent includes 6-12 parts of carbomer
With 2-6 parts of propolis.
3. a kind of mouth ulcer paster as claimed in claim 1, it is characterised in that the coating agent is selected from acrylic resin II
Or acrylic resin III.
4. a kind of mouth ulcer paster as claimed in claim 1, it is characterised in that the oyster shell whiting base quick-dissolving agent is by marine alga
The oyster shell whiting of sour sodium cladding.
5. a kind of mouth ulcer paster as claimed in claim 4, it is characterised in that the preparation side of the oyster shell whiting base quick-dissolving agent
Method is as follows：Oyster shell whiting is cleaned, is first calcined at 300-400 DEG C and 100-200 mesh is ground to after 0.5-1.5h, cooling, after cleaning
Continuation calcines 2-4h at 600-800 DEG C；400-800 mesh is ground to after cooling, calcined shell powder is obtained standby；With ethanol by sea
Mosanom is soaked, and calcined shell powder is added in the sodium alginate of its 0.5-1.0 times of quality and is uniformly dispersed, and shellfish is obtained after drying
Shell powder base quick-dissolving agent.
6. a kind of mouth ulcer paster as claimed in claim 1, it is characterised in that the lubricant is selected from magnesium stearate, cunning
Stone flour, superfine silica gel powder or stearic acid.
7. a kind of mouth ulcer paster as claimed in claim 1, it is characterised in that described adhesive is ethanol.
8. the preparation method of a kind of mouth ulcer paster as described in one of claim 1-7, it is characterised in that including following step
Suddenly：
(1) each raw material is weighed by proportioning；
(2) Notogineng Extract, American ginseng extract, Honegsukle flower P.E, Radix Sangusorbae extract, bletilla striata extract, radix scutellariae are extracted
Thing, borneol, chitosan, oyster shell whiting base quick-dissolving agent, sodium carboxymethylcellulose are well mixed, and are subsequently added into snake oil and are well mixed；
(3) it is the compound of step (2) and forming agent, mix lubricant is uniform, after being soaked with adhesive, carry out tabletting；
(4) it is coated after tabletting with coating agent, mouth ulcer paster is made after drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710490166.XA CN107260957A (en) | 2017-06-25 | 2017-06-25 | A kind of mouth ulcer paster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710490166.XA CN107260957A (en) | 2017-06-25 | 2017-06-25 | A kind of mouth ulcer paster and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108404197A (en) * | 2018-04-28 | 2018-08-17 | 陈建峰 | A kind of styptic powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048816A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof |
| CN102058734A (en) * | 2009-11-16 | 2011-05-18 | 天津必佳药业集团有限公司 | Chinese medicinal adhesive tablets for treating oral mucosa ulcer |
| CN106065941A (en) * | 2015-04-23 | 2016-11-02 | 丰田自动车株式会社 | The control device of vehicle |
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| CN102048816A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof |
| CN102058734A (en) * | 2009-11-16 | 2011-05-18 | 天津必佳药业集团有限公司 | Chinese medicinal adhesive tablets for treating oral mucosa ulcer |
| CN106065941A (en) * | 2015-04-23 | 2016-11-02 | 丰田自动车株式会社 | The control device of vehicle |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108404197A (en) * | 2018-04-28 | 2018-08-17 | 陈建峰 | A kind of styptic powder |
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Application publication date: 20171020 |