CN107137540A - It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof - Google Patents
It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof Download PDFInfo
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- CN107137540A CN107137540A CN201710490153.2A CN201710490153A CN107137540A CN 107137540 A CN107137540 A CN 107137540A CN 201710490153 A CN201710490153 A CN 201710490153A CN 107137540 A CN107137540 A CN 107137540A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
Abstract
The present invention relates to technical field of Chinese patent medicine, disclose a kind of for treating Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof.The tablet includes the raw material of following parts by weight：15 25 parts of bupleurum extract, 10 20 parts of Baical Skullcap root P.E, 35 parts of ginseng extract, 35 parts of mint extract, 35 parts of chrysanthemum extract, 35 parts of Honegsukle flower P.E, 13 parts of radix glycyrrhizae, 59 parts of borneol, 5 15 parts of hydroxypropyl methyl cellulose, 26 parts of oyster shell whiting base quick-dissolving agent, 13 17 parts of filler, 37 parts of lubricant, 48 parts of adhesive, 25 parts of gadol extract, 47 parts of Monochoria vaginalis and perfume (or spice) eat 25 parts.Active constituent content is high in Instant Chinese patent medicine tablet of the present invention for treating pharyngitis, and its dissolution efficiency in digestive tract environment is high, easily absorbs, therefore good drug efficacy.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, more particularly to a kind of Instant Chinese patent medicine tablet and its system for being used to treat pharyngitis
Preparation Method.
Background technology
Pharyngitis is pharyngeal nonspecific inflammation, is that various microorganism infections are pharyngeal and produce the general designation of inflammation, can be independent
In the presence of also or being the premonitory symptom of some diseases with rhinitis, tonsillitis and laryngitis and depositing.Acpuei pharyngitis can be divided into and slow
Property pharyngitis.Acpuei pharyngitis is the acute inflammation of pharyngeal mucous membrane and sub-mucosal tissues, and pharynx lymphoid tissue is often involved, and inflammation early stage can
Limitation, whole pharyngeal cavity is often can relate to disease progression, with the autumn and winter and at the end of winter and the beginning of spring more typical.Pharyngeal drying is mainly shown as, is burnt
Heat, pain swallows pain substantially, congestion of throat swelling etc..Chronic pharyngitis can be divided into chronic simple pharyngitis, chronic hypertrophic again
Pharyngitis and atrophic pharyngitis, wherein chronic simple pharyngitis are more common, and lesion shows as pharyngeal mucous membrane chronic mainly in mucous layer
Connective tissue proliferation under hyperemia, mucous membrane and mucous membrane, mucous gland can be loose, and secreting function is hyperfunction, and mucilage secretion increases.Patient often coughs up
Going out glutinous phlegm in pharynx, or feel pharyngeal has foreign body sensation, can not cough up, does not swallow.Common adult, the course of disease is long, easily recurrence, and symptom is stupid
Gu, it is more difficult to cure.
The patent of Application No. 201310393761.3 discloses a kind of Chinese medicinal capsule for treating chronic pharyngitis, can eliminate lung
The inflammation and intra-alveolar edema of leaf, thus reach radical cure laryngitis purpose, its by radix bupleuri, ginseng, the wind-weed, the tuber of dwarf lilyturf, indigo naturalis, borneol,
The traditional Chinese medicines such as dried peppermint leaf are formed.
Application No. CN201510551747.0 patent discloses a kind of Chinese medicine preparation for treating chronic pharyngitis, takes following
The primary raw material of weight proportion is prepared from：8-12 parts of the coptis, 30-35 parts of borneol, 15-20 parts of almond, 5-10 parts of tendril-leaved fritillary bulb, spider
5-7,100-150 parts of honey, 8-14 parts of honeysuckle, 10-15 parts of radix glycyrrhizae.It is slow that Chinese medicine preparation of the present invention is based on traditional Chinese medical herbal treatment
The principle of property pharyngitis.The medicinal material of selection has the antipruritic effect of relieving cough and reducing sputum, moistening lung, for chronic pharyngitis diagnosis and treatment based on an overall analysis of the illness and the patient's condition, belongs to
The prescription treated both principal and secondary aspect of disease.There is fabulous therapeutic action to chronic pharyngitis.
Application No. CN201510047340.4 patent disclose a kind of Chinese medicine composition for treating chronic pharyngitis and its
Preparation method, the Chinese medicine composition of described treatment chronic pharyngitis includes reed rhizome, Chinese olive, radix glycyrrhizae, chrysanthemum, radix scrophulariae, semen brassicae, stone
Long Rui, terminaliae billericae,fructus, justicia.Preparation method is：Dry reed rhizome, Chinese olive, radix glycyrrhizae, chrysanthemum, radix scrophulariae, semen brassicae, Shi Long are taken respectively
Rui, terminaliae billericae,fructus, justicia, respectively smash above-mentioned Chinese medicine to pieces, are ground after smashing to pieces, and it is powdered to be ground to Chinese medicine, is pressed
It is 8-14 parts that weight, which takes the reed rhizome after grinding, Chinese olive is 4-10 parts, radix glycyrrhizae is 5-11 parts, chrysanthemum is 4-9 parts, radix scrophulariae is 6-12
Part, semen brassicae be 5-9 part, Ranunculus sceleratus be 4-9 part, terminaliae billericae,fructus be 4-8 parts, justicia be 2-6 parts, by above-mentioned powder mixing
It is even, to treat the Chinese medicine composition of chronic pharyngitis.
The defect that said medicine is present is directly to be mixed to prepare after each taste Chinese medicine milling, on the one hand, ingredients is not
By extracting, cause active constituent content in medicinal material relatively low, drug effect is have impact on to a certain extent.On the other hand, due to without
Extract, the digestion, dissolved efficiency after drug administration in alimentary canal are low, be difficult to absorb.And even across extraction, due to medicine
Containing the water-soluble poor material such as a large amount of glycosides, ketone in material active ingredient, the dissolution rate of these materials is slower, also can shadow
Ring and absorb.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides it is a kind of be used for treat pharyngitis Instant Chinese patent medicine tablet and
Its preparation method.Active constituent content is high in Instant Chinese patent medicine tablet of the present invention for treating pharyngitis, and it is in digestion
Dissolution efficiency is high in road environment, easily absorbs, therefore good drug efficacy.
The present invention concrete technical scheme be：A kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis, including it is following heavy
Measure the raw material of part：15-25 parts of bupleurum extract, 10-20 parts of Baical Skullcap root P.E, 3-5 parts of ginseng extract, mint extract 3-5
Part, 3-5 parts of chrysanthemum extract, 3-5 parts of Honegsukle flower P.E, 1-3 parts of radix glycyrrhizae, 5-9 parts of borneol, hydroxypropyl methyl cellulose 5-15
Part, 2-6 parts of oyster shell whiting base quick-dissolving agent, 13-17 parts of filler, 3-7 parts of lubricant, 4-8 parts of adhesive, gadol extract 2-5
Part, 4-7 parts of Monochoria vaginalis and perfume (or spice) eat 2-5 parts.
Main ingredient composition of the invention first includes bupleurum extract, Baical Skullcap root P.E, ginseng extract, mint extract,
Chrysanthemum extract, Honegsukle flower P.E, radix glycyrrhizae and borneol；Those directly just add traditional Chinese medicinal material raw materials without purification with other
Medicine compare, the invalid impurity component due to reducing so that the content of composition active drug composition is higher.
Secondly, the present invention for after medicine is taken in the prior art in human body alimentary canal specified temp and faintly acid
Active ingredient rate of dissolution is relatively slow in environment, be difficult the technical problem of absorption, employs hydroxypropyl methyl cellulose and oyster shell whiting
Base quick-dissolving agent is coordinated so that medicine in the specific environment of human body alimentary canal can fater disintegration, dissolution, in favor of timely
Absorb.Wherein, carboxyl bear electricity intermolecular repulsion under carboxyl, alkaline environment is contained in the molecule of hydroxypropyl methyl cellulose to be made to twine
Around macromolecule unfold and dissolve, therefore there is under weak acid environment preferable dissolubility.
Further, the oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate.
Further, the preparation method of the oyster shell whiting base quick-dissolving agent is as follows：Oyster shell whiting is cleaned, first at 300-400 DEG C
Lower calcining 0.5-1.5h, is ground to 100-200 mesh after cooling, continue to calcine 2-4h at 600-800 DEG C after cleaning；Ground after cooling
400-800 mesh is milled to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to it
It is uniformly dispersed in the sodium alginate of 0.5-1.0 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
The present invention oyster shell whiting base quick-dissolving agent in, major matrix material for calcining after oyster shell whiting, and its surface by
Sodium alginate is coated.In its preparation process, first to oyster shell whiting step calcination under the above specified conditions, in the first step, first
The biological organic matter adhered in shell is removed；In second step, the main component of oyster shell whiting is calcium carbonate, and calcium carbonate is by high temperature
Calcining and decomposing is calcium oxide and carbon dioxide, then is crushed as compared with little particulate.After the calcining of above-mentioned two steps specified conditions, by
In the removal and the disengaging of carbon dioxide of organic matter, the nanometer, micron-sized largely communicated can be produced on shell matrix
Micropore so that it has larger specific surface area, so that with outstanding adsorptivity and reactivity.Shell after thus calcining
Powder has extremely strong adsorptivity and respond for water.And certain heat can be produced after its moisture absorption reaction, so that plus
The disintegration of fast medicine, helps the dissolution of active ingredient.Have and sodium alginate also has outstanding hygroscopicity, after its moisture absorption glutinous
Property, easy film forming is coated on behind oyster shell whiting surface, on the one hand can absorb Environmental Water and pass it to oyster shell whiting, makees
The intermediary transmitted for moisture；On the other hand because oyster shell whiting moisture absorption heat release may have a certain impact to human body alimentary canal tool,
Cause human body uncomfortable, therefore sodium alginate coats oyster shell whiting, can avoid its directly with a large amount of water haptoreactions and big calorimetric
Amount；And due to the isolation of sodium alginate after reaction, moment is not transferred to outside to heat, and security is higher.The rhodiola root of addition
Phenyl propyl activity in extract is stronger, with effective anti-oxidation efficacy, coordinates raw material using medicine being made to be had by human body
The absorption of effect, improves the utilization rate of drug effect.
In addition, being also added into Monochoria vaginalis in the present invention and perfume (or spice) is eaten, Monochoria vaginalis has clearing heat and detoxicating effect, cure mainly dysentery,
Enteritis, acute tonsillitis, gums abscess, erysipelas, furunculosis etc.；Perfume (or spice), which is eaten, has effects that clearing heat and promoting diuresis, cures mainly heatstroke vomiting and diarrhoea, dysentery
Disease, damp and hot edema, gingivitis, backache, herpes zoster etc..Monochoria vaginalis and perfume (or spice) are eaten can be done directly on bottleneck throat with reference to above-mentioned raw materials
Position, is conducive to mucous membrane directly to absorb, immediately enters under mucous membrane, directly participate in blood circulation, and heat-clearing, cool blood, purging intense heat are played rapidly
Effect that removing toxic substances, enriching yin wet one's whistle, reaches dryness-heat, the purpose of the pharyngeal slight illness of solution of clearing lung-heat stomach.This herbal medicine efficacy wide spectrum, curative effect shows
Write, wet one's whistle by clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, enriching yin, the effect such as antiviral, anti-inflammation.It is fumigated especially for because of lung stomach
The sphagitis caused by a variety of causes such as scorching, removing toxic substances, wound, the turbid, infection of phlegm have peculiar curative effect.
Alternatively, the filler is selected from lactose, starch or pregelatinized starch.
Alternatively, the lubricant is selected from magnesium stearate, talcum powder, superfine silica gel powder, stearic acid or polyethylene glycol.
Alternatively, described adhesive is ethanol.Ethanol not only has preferable wetting action to various raw materials, and will not
So that the material easily absorbed water in raw material in preparation process with regard to dissolving.
The above-mentioned preparation method for being used to treat the Instant Chinese patent medicine tablet of pharyngitis, comprises the following steps：
(1) each raw material is weighed by proportioning.
(2) by bupleurum extract, Baical Skullcap root P.E, ginseng extract, mint extract, chrysanthemum extract, honeysuckle carries
Thing is taken, radix glycyrrhizae, borneol, hydroxypropyl methyl cellulose, oyster shell whiting base quick-dissolving agent, filler is well mixed.
(3) it will be bonded with adhesive after the compound wetting of step (2), added after drying after lubricant and use tablet press machine pressure
Piece, is made tablet.
The invention has the advantages that：Active ingredient in Instant Chinese patent medicine tablet of the present invention for treating pharyngitis
Content is high, and its dissolution efficiency in digestive tract environment is high, easily absorbs, therefore good drug efficacy.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1
A kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：Bupleurum extract 22
Part, 13 parts of Baical Skullcap root P.E, 4 parts of ginseng extract, 4 parts of mint extract, 4 parts of chrysanthemum extract, 4 parts of Honegsukle flower P.E,
2 parts of radix glycyrrhizae, 7 parts of borneol, 10 parts of hydroxypropyl methyl cellulose, 4 parts of oyster shell whiting base quick-dissolving agent, 15 parts of pregelatinized starch, poly- second two
5 parts of alcohol, 6 parts of ethanol adhesive, 5 parts of gadol extract, 7 parts of Monochoria vaginalis and perfume (or spice) eat 2 parts.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 380 DEG C and 100-200 mesh is ground to after 1h, cooling, continue to calcine 3h at 700 DEG C after cleaning；Ground after cooling
400-800 mesh is milled to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, by calcined shell powder be added to its 0.7
It is uniformly dispersed in the sodium alginate of times quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 2
A kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：Bupleurum extract 20
Part, 15 parts of Baical Skullcap root P.E, 3 parts of ginseng extract, 5 parts of mint extract, 3 parts of chrysanthemum extract, 5 parts of Honegsukle flower P.E,
1 part of radix glycyrrhizae, 8 parts of borneol, 5 parts of hydroxypropyl methyl cellulose, 6 parts of oyster shell whiting base quick-dissolving agent, 14 parts of lactose, 7 parts of magnesium stearate, second
8 parts of alcohol adhesive, 4 parts of Monochoria vaginalis and perfume (or spice) eat 5 parts.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 300 DEG C and 100-200 mesh is ground to after 1.5h, cooling, continue to calcine 4h at 600 DEG C after cleaning；After cooling
400-800 mesh is ground to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to it
It is uniformly dispersed in the sodium alginate of 1.0 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 3
A kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：Bupleurum extract 25
Part, 10 parts of Baical Skullcap root P.E, 5 parts of ginseng extract, 3 parts of mint extract, 5 parts of chrysanthemum extract, 3 parts of Honegsukle flower P.E,
3 parts of radix glycyrrhizae, 6 parts of borneol, 15 parts of hydroxypropyl methyl cellulose, 2 parts of oyster shell whiting base quick-dissolving agent, 13 parts of starch, 6 parts of superfine silica gel powder,
4 parts of ethanol adhesive, 5 parts of Monochoria vaginalis and perfume (or spice) eat 3 parts.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 350 DEG C and 100-200 mesh is ground to after 1h, cooling, continue to calcine 3.5h at 650 DEG C after cleaning；After cooling
400-800 mesh is ground to, calcined shell powder is obtained standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to it
It is uniformly dispersed in the sodium alginate of 0.8 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 4
A kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：Bupleurum extract 18
Part, 12 parts of Baical Skullcap root P.E, 5 parts of ginseng extract, 5 parts of mint extract, 5 parts of chrysanthemum extract, 5 parts of Honegsukle flower P.E,
2 parts of radix glycyrrhizae, 8 parts of borneol, 12 parts of hydroxypropyl methyl cellulose, 5 parts of oyster shell whiting base quick-dissolving agent, 15 parts of pregelatinized starch, talcum powder 3
Part, 5 parts of ethanol adhesive, 6 parts of Monochoria vaginalis and perfume (or spice) eat 4 parts.
The oyster shell whiting base quick-dissolving agent is the oyster shell whiting coated by sodium alginate, and its preparation method is as follows：Oyster shell whiting is washed
Only, first calcined at 320 DEG C and 100-200 mesh is ground to after 1.5h, cooling, continue to calcine 2.5h at 750 DEG C after cleaning；Cooling
After be ground to 400-800 mesh, obtain calcined shell powder standby；Sodium alginate is soaked with ethanol, calcined shell powder is added to
It is uniformly dispersed in the sodium alginate of its 1.0 times of quality, oyster shell whiting base quick-dissolving agent is obtained after drying.
Embodiment 5
A kind of preparation method for being used to treat the Instant Chinese patent medicine tablet of pharyngitis, comprises the following steps：
(1) each raw material is weighed by proportioning.
(2) by bupleurum extract, Baical Skullcap root P.E, ginseng extract, mint extract, chrysanthemum extract, honeysuckle carries
Thing is taken, radix glycyrrhizae, borneol, hydroxypropyl methyl cellulose, oyster shell whiting base quick-dissolving agent, filler is well mixed.
(3) it will be bonded with adhesive after the compound wetting of step (2), added after drying after lubricant and use tablet press machine pressure
Piece, is made tablet.
Comparative example 1
A kind of Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：22 parts of bupleurum extract, radix scutellariae
13 parts of extract, 4 parts of ginseng extract, 4 parts of mint extract, 4 parts of chrysanthemum extract, 4 parts of Honegsukle flower P.E, 2 parts of radix glycyrrhizae,
7 parts of borneol, 29 parts of pregelatinized starch, 5 parts of polyethylene glycol, 6 parts of ethanol adhesive.
Comparative example 2
A kind of Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：22 parts of bupleurum extract, radix scutellariae
13 parts of extract, 4 parts of ginseng extract, 4 parts of mint extract, 4 parts of chrysanthemum extract, 4 parts of Honegsukle flower P.E, 2 parts of radix glycyrrhizae,
7 parts of borneol, 10 parts of hydroxypropyl methyl cellulose, 19 parts of pregelatinized starch, 5 parts of polyethylene glycol, 6 parts of ethanol adhesive.
Comparative example 3
A kind of Chinese patent medicine tablet for being used to treat pharyngitis, includes the raw material of following parts by weight：22 parts of bupleurum extract, radix scutellariae
13 parts of extract, 4 parts of ginseng extract, 4 parts of mint extract, 4 parts of chrysanthemum extract, 4 parts of Honegsukle flower P.E, 2 parts of radix glycyrrhizae,
7 parts of borneol, 4 parts of oyster shell whiting base quick-dissolving agent, 25 parts of pregelatinized starch, 5 parts of polyethylene glycol, 6 parts of ethanol adhesive.
Active ingredient (selection bupleurum extract and Huang are carried out to embodiment 1-4 and comparative example 1-3 Chinese patent medicine tablet
A kind of reed mentioned in ancient books extract, which is used as, represents detection composition) dissolution rate tested, test condition is as follows, by 5g Chinese patent medicine tablet throw in
200mL temperature is 38 ± 0.5 DEG C, and pH is in 6.8 water, respectively at 5min, 15min, 30min and 60min detects active ingredient
Dissolution rate, it is as a result as follows：
By data comparison, in embodiment 1-4 the dissolution efficiency of effective ingredient apparently higher than comparative example 1-3,
Dissolution rate particularly in 30min, lifting is notable, and if fully absorbed medicine in 30min, has been more beneficial for
Effect, therapeutic effect is more preferable.
Raw materials used in the present invention, equipment, is the conventional raw material, equipment of this area unless otherwise noted；In the present invention
Method therefor, is the conventional method of this area unless otherwise noted.
It is described above, only it is presently preferred embodiments of the present invention, not the present invention is imposed any restrictions, it is every according to the present invention
Any simple modification, change and equivalent transformation that technical spirit is made to above example, still fall within the technology of the present invention side
The protection domain of case.
Claims (7)
1. a kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis, it is characterised in that include the raw material of following parts by weight：Radix bupleuri
15-25 parts of extract, 10-20 parts of Baical Skullcap root P.E, 3-5 parts of ginseng extract, 3-5 parts of mint extract, chrysanthemum extract 3-5
Part, 3-5 parts of Honegsukle flower P.E, 1-3 parts of radix glycyrrhizae, 5-9 parts of borneol, 5-15 parts of hydroxypropyl methyl cellulose, oyster shell whiting base is instant
2-6 parts of agent, 13-17 parts of filler, 3-7 parts of lubricant, 4-8 parts of adhesive, 2-5 parts of gadol extract, 4-7 parts of Monochoria vaginalis and
Perfume (or spice) eats 2-5 parts.
2. a kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis as claimed in claim 1, it is characterised in that the shell
Powder base quick-dissolving agent is the oyster shell whiting coated by sodium alginate.
3. a kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis as claimed in claim 2, it is characterised in that the shell
The preparation method of powder base quick-dissolving agent is as follows：Oyster shell whiting is cleaned, 0.5-1.5h is first calcined at 300-400 DEG C, is ground after cooling
To 100-200 mesh, continue to calcine 2-4h at 600-800 DEG C after cleaning；400-800 mesh is ground to after cooling, obtains calcining shellfish
Shell powder is standby；Sodium alginate is soaked with ethanol, calcined shell powder is added in the sodium alginate of its 0.5-1.0 times of quality and divided
Dissipate uniform, oyster shell whiting base quick-dissolving agent is obtained after drying.
4. a kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis as claimed in claim 1, it is characterised in that the filling
Agent is selected from lactose, starch or pregelatinized starch.
5. a kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis as claimed in claim 1, it is characterised in that the lubrication
Agent is selected from magnesium stearate, talcum powder, superfine silica gel powder, stearic acid or polyethylene glycol.
6. a kind of Instant Chinese patent medicine tablet for being used to treat pharyngitis as claimed in claim 1, it is characterised in that the bonding
Agent is ethanol.
7. a kind of preparation method for being used to treat the Instant Chinese patent medicine tablet of pharyngitis as described in one of claim 1-6, its
It is characterised by comprising the following steps：
(1) each raw material is weighed by proportioning；
(2) by bupleurum extract, Baical Skullcap root P.E, ginseng extract, mint extract, chrysanthemum extract, Honegsukle flower P.E,
Radix glycyrrhizae, borneol, hydroxypropyl methyl cellulose, oyster shell whiting base quick-dissolving agent, filler is well mixed；
(3) it will be bonded with adhesive after the compound wetting of step (2), added after drying and tabletting machine is used after lubricant,
Tablet is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710490153.2A CN107137540A (en) | 2017-06-25 | 2017-06-25 | It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710490153.2A CN107137540A (en) | 2017-06-25 | 2017-06-25 | It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107137540A true CN107137540A (en) | 2017-09-08 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710490153.2A Withdrawn CN107137540A (en) | 2017-06-25 | 2017-06-25 | It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1636584A (en) * | 2003-10-31 | 2005-07-13 | 成都三明药物研究所 | Medicine composition for treating upper respiratory tract infection and its prepn process |
| CN102512533A (en) * | 2011-12-16 | 2012-06-27 | 曲靖开发区格力康生物科技发展有限公司 | Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof |
| CN103432379A (en) * | 2013-08-26 | 2013-12-11 | 任国祚 | Traditional Chinese medicine capsule for treating chronic pharyngitis |
| CN105055828A (en) * | 2015-09-01 | 2015-11-18 | 陈啸天 | Traditional Chinese medicine preparation for treating chronic pharyngitis and preparing method thereof |
-
2017
- 2017-06-25 CN CN201710490153.2A patent/CN107137540A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1636584A (en) * | 2003-10-31 | 2005-07-13 | 成都三明药物研究所 | Medicine composition for treating upper respiratory tract infection and its prepn process |
| CN102512533A (en) * | 2011-12-16 | 2012-06-27 | 曲靖开发区格力康生物科技发展有限公司 | Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof |
| CN103432379A (en) * | 2013-08-26 | 2013-12-11 | 任国祚 | Traditional Chinese medicine capsule for treating chronic pharyngitis |
| CN105055828A (en) * | 2015-09-01 | 2015-11-18 | 陈啸天 | Traditional Chinese medicine preparation for treating chronic pharyngitis and preparing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 梅全喜: "《现代中药药理与临床应用手册》", 31 October 2016 * |
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Application publication date: 20170908 |
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