CN102512533A - Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof - Google Patents
Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating swelling and pain in throat and a preparation thereof, wherein the traditional Chinese medicine composition contains traditional Chinese medicines in the following parts by weight: 50-200 parts of honeysuckle, 50-200 parts of mother chrysanthemum, 50-200 parts of houttuynia cordata, 50-200 parts of radix bupleuri, 0.1-5 parts of menthol crystal and 0.05-5.0 parts of borneol. The traditional Chinese medicine composition provided by the invention is mainly used for swelling and pain in throat caused by acute tonsillitis, acute pharyngitis, simple laryngitis, peritonsillar abscess etc.
Description
Technical field
The present invention relates to medical invention field, be specifically related to a kind of Chinese medicine composition and preparation thereof of treating laryngopharynx swelling and pain.
Background technology
Laryngopharynx swelling and pain (sore throat) is the cardinal symptom of oropharynx and laryngopharynx portion pathological changes, with the bottleneck throat congestion and swelling pain, to swallow discomfort be characteristic, claims again " sore throat ".Laryngopharynx swelling and pain is shown in acute tonsillitis, acute pharyngitis and simple laryngitis, the peritonsillar abscess etc. of western medicine.
Laryngopharynx swelling and pain is a kind of modal disease, and it is mainly in the cold season in 1 year, and flu, tonsillitis, sinusitis, pertussis, pharyngolaryngitis and viral infection are usually all with throat pain.Most acute throat pains can disappear in a couple of days to several weeks automatically; Yet,, need see the doctor if pain continues to exist or in several days, increase the weight of.Because if do not treat for a long time, this disease possibly cause rheumatic fever, harm heart and kidney.
Oral have LIUSHEN WAN, QINGRE JIEDU KOUFUYE, a Radix Isatidis electuary.Buccal Herba Pileae Scriptae Tabellae arranged, watermelon crystal buccal tablet, JINSANGZIHOUBAO etc., effect is all good.
After but oral drugs get into gastrointestinal tract in the said medicine; Get into blood through gastrointestinal tract and carry out the whole body distribution, few part needs concentration can all reach throat, and the effectiveness that arrives throat obviously weakens; And existing buccal tablet and spray can directly act on the throat; Drug level concentrates in diseased region, and is rapid-action, rapidly relief of symptoms.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition of treating laryngopharynx swelling and pain.
The object of the invention also provides the preparation of the Chinese medicine composition of above-mentioned laryngopharynx swelling and pain.
Another object of the present invention is to provide preparing such formulations.
A kind of Chinese medicine composition of treating laryngopharynx swelling and pain provided by the invention contains following parts by weight of Chinese traditional medicine: Flos Lonicerae 50-200 part, Flos Chrysanthemi Indici 50-200 part, Herba Houttuyniae 50-200 part, Radix Bupleuri 50-200 part, Mentholum 0.1-5 part and Borneolum Syntheticum 0.05-5.0 part.
Preferably, Chinese medicine composition provided by the invention contains following parts by weight of Chinese traditional medicine: Flos Lonicerae 100-150 part, Flos Chrysanthemi Indici 100-150 part, Herba Houttuyniae 100-150 part, Radix Bupleuri 100-150 part, Mentholum 0.5-3 part and Borneolum Syntheticum 0.1-1.0 part.
Further preferably, Chinese medicine composition provided by the invention contains following parts by weight of Chinese traditional medicine: 0.5 part of 125 parts of Flos Loniceraes, 125 parts of Flos Chrysanthemi Indicis, 125 parts of Herba Houttuyniae, 125 parts of Radix Bupleuri, 1 part of Mentholum and Borneolum Syntheticum.
Chinese medicine composition provided by the invention further also contains eucalyptus oil, and the w/v g of above-mentioned Chinese medicine and eucalyptus oil: ml is 200-500: 1-5, is preferably 200-300: 1-2.
The present invention also provides the preparation that contains above-mentioned Chinese medicine composition, and said preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier or excipient.
Said preparation is solid or liquid preparation, and solid preparation is sheet, capsule, granule or spray, and said solid preparation is preferably buccal tablet, spray; Liquid preparation is an oral liquid.
Said pharmaceutically acceptable carrier or diluent are meant the pharmaceutical carrier that pharmaceutical field is conventional, are selected from filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives one or more.
Said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.;
Said binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.;
Said disintegrating agent is selected from microcrystalline Cellulose, pregelatinized Starch, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose;
Said lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate;
Said suspending agent is selected from micropowder silica gel, Cera Flava, cellulose, solid polyethylene glycol;
Said wetting agent is selected from glycerol, tween 80, ethyoxyl castor oil hydrogenated or lecithin;
Said solvent is selected from ethanol, liquid polyethylene glycol, isopropyl alcohol, tween 80, glycerol, propylene glycol or vegetable oil, and said vegetable oil is selected from soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, mediation wet goods;
Said surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, polyoxyethylene-polyoxypropylene copolymer, tween 80 etc.;
Said correctives is selected from Icing Sugar, aspartame, Sucralose, essence, citric acid or saccharin sodium.
Preferably, the preparation that contains Chinese medicine composition provided by the invention is a spray, is made up of above-mentioned Chinese medicine composition and tween 80.Further preferred, this spray, be grouped into by the one-tenth of following weight portion: above-mentioned Chinese medicine composition 500-1000g and tween 80 30-100g form.
Preferably, the preparation that contains Chinese medicine composition provided by the invention is a buccal tablet, is made up of in above-mentioned Chinese medicine composition and the following adjuvant one or more: filler, disintegrating agent, binding agent or correctives.
The present invention also provides preparing such formulations, may further comprise the steps:
1) above seven flavors, Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add water and soak in right amount after 3-8 hour and carry out vapor distillation, collect the about 600-1000ml of distillate, and are subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and pharmaceutically acceptable carrier or excipient then, be prepared into preparation according to conventional method.
The present invention also provides above-mentioned spray preparing process, and this method may further comprise the steps: above seven flavors, Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add an amount of the immersion after 4 hours of water and carry out vapor distillation, collect the about 800ml of distillate, and are subsequent use.Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and tween 80 more respectively, fully stirring and evenly mixing; Then, while stirring, mixing filters, and processes 1000ml in the adding distillate, and packing promptly gets.
The present invention also provides above-mentioned Chinese medicine composition and the application of preparation in the medicine of preparation treatment laryngopharynx swelling and pain thereof, and this laryngopharynx swelling and pain symptom is the symptom of performances such as acute tonsillitis, acute pharyngitis and simple laryngitis or peritonsillar abscess.
The Chinese medicine composition and the preparation thereof of treatment laryngopharynx swelling and pain provided by the invention have the following advantages:
1, in the medicine of the present invention:
Flos Lonicerae is the dry flower of Caprifoliaceae Radix Ophiopogonis Lonicera japonica Thunb. or the flower that band is just opened.The property sweet, cold.Return lung, the heart, stomach warp; Has heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Be used for the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Flos Chrysanthemi Indici is the dry head titbit of feverfew Herba Dendranthematis indici Chrysanthenum indicum L..Nature and flavor are bitter, hot, are slightly cold, and return liver, heart channel.Heat-clearing and toxic substances removing, the pathogenic fire purging suppressing the hyperactive liver is used for the furuncle carbuncle, conjunctival congestion and swelling pain, it is dizzy to have a headache.
Herba Houttuyniae is fresh herb or the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Suffering is slightly cold.Return lung meridian.Heat-clearing and toxic substances removing, the eliminating carbuncle evacuation of pus; Inducing diuresis for treating stranguria syndrome.Be used for the lung abscess vomiting pus; The expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Radix Bupleuri is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..The property hot, bitter, be slightly cold.Return liver, gallbladder, lung meridian.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for cold, fever, alternate attack of chill and fever, sternal rib pain, menoxenia, uterine prolapse, proctoptosis.
Mentholum is fresh stem and the Ye Jing steam distillation of labiate Mentha haplocalyx Briq., freezing, a kind of saturated cyclic alcohol that recrystallization obtains, is l-1-methyl-4-isopropyl cyclohexanol-3.Acrid in the mouth, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, the headache, conjunctival congestion, sore throat, aphtha, rubella, measles, costa sternales feeling of distension and oppression.Borneolum Syntheticum (borneolum syntheticum) C
10H
18O, acrid in the mouth, hardship are slightly cold.GUIXIN, spleen, lung meridian.The refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be used for calentura coma, convulsions, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, obstruction of qi in the chest and cardialgia, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Eucalyptus oil is that myrtle Eucalyptus globulus Labill Eucalyptus globulus Labill., canella Camphor tree Cinnamomum camphora (L.) Presl or above-mentioned two sections belong to the volatile oil of other plant through vapor extraction together.Acrid in the mouth, hardship; Cold in nature.Return lung; Stomach; Spleen; Liver Channel.Dispelling wind to relieve the exterior syndrome; Heat-clearing and toxic substances removing; Phlegm-eliminiating and qi-regulating; Killing parasites for relieving itching.Be used for flu, influenza, dysentery, enteritis, arthralgia, cystitis is scalded scabies, erysipelas, neurodermatitis, eczema, carbuncle pyogenic infections from tumour or sore.
The effect of clearing throat is played by full side.
2, medical effect experiment shows, the present invention has the effect of treatment laryngopharynx swelling and pain, and not only pain relieving can also be subsided a swelling.
3, Chinese medicine composition provided by the invention is the distinguished veteran doctors of TCM clinical proved recipe; The hospital preparation that adopts the technological development of modern Chinese medicine formulation preparation to form; Independent use can be treated laryngopharynx swelling and pain through clinical trial Chinese medicine composition provided by the invention, and effect is superior to existing product.Can also be equipped with other drug and use, be used to alleviate the symptom of laryngopharynx swelling and pain, not only pain relieving also has the detumescence function.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1: the spray of treatment laryngopharynx swelling and pain
1, forms: Flos Lonicerae 125g, Flos Chrysanthemi Indici 125g, Herba Houttuyniae 125g, Radix Bupleuri 125g, Mentholum 1g, Borneolum Syntheticum 0.5g, eucalyptus oil 2ml, tween 80 2ml.
2, method for preparing:
1) Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add an amount of the immersion after 4 hours of water and carries out vapor distillation, collect the about 800ml of distillate, and is subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and tween 80 more respectively, abundant stirring and evenly mixing adds in the distillate while stirring then, and mixing filters, and processes 1000ml, and packing promptly gets.
3, specification: the 8ml/ bottle contains crude drug 0.50g.
Embodiment 2: the spray of treatment laryngopharynx swelling and pain
1, forms: Flos Lonicerae 150g, Flos Chrysanthemi Indici 100g, Herba Houttuyniae 100g, Radix Bupleuri 150g, Mentholum 3g, Borneolum Syntheticum 1g, eucalyptus oil 3ml, tween 80 2ml
2, method for preparing:
1) Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add an amount of the immersion after 4 hours of water and carries out vapor distillation, collect the about 600ml of distillate, and is subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and tween 80 more respectively, abundant stirring and evenly mixing adds in the distillate while stirring then, and mixing filters, and processes 1000ml, and packing promptly gets.
3, specification: the 8ml/ bottle contains crude drug 0.50g.
Embodiment 3: the spray of treatment laryngopharynx swelling and pain
1, forms: Flos Lonicerae 100g, Flos Chrysanthemi Indici 150g, Herba Houttuyniae 150g, Radix Bupleuri 100g, Mentholum 1g, Borneolum Syntheticum 1g, eucalyptus oil 1.5ml, tween 80 2ml
2, method for preparing:
1) Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add an amount of the immersion after 6 hours of water and carries out vapor distillation, collect the about 800ml of distillate, and is subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and tween 80 more respectively, abundant stirring and evenly mixing adds in the distillate while stirring then, and mixing filters, and processes 1000ml, and packing promptly gets.
3, specification: the 8ml/ bottle contains crude drug 0.50g.
Embodiment 4: the spray of treatment laryngopharynx swelling and pain
1, forms: Flos Lonicerae 80g, Flos Chrysanthemi Indici 120g, Herba Houttuyniae 200g, Radix Bupleuri 100g, Mentholum 2g, Borneolum Syntheticum 1g, eucalyptus oil 2ml, tween 80 2ml
2, method for preparing:
1) Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add an amount of the immersion after 4 hours of water and carries out vapor distillation, collect the about 900ml of distillate, and is subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and tween 80 more respectively, abundant stirring and evenly mixing adds in the distillate while stirring then, and mixing filters, and processes 1000ml, and packing promptly gets.
3, specification: the 8ml/ bottle contains crude drug 0.50g.
Embodiment 5: the buccal tablet of treatment laryngopharynx swelling and pain
1, forms: Flos Lonicerae 200g, Flos Chrysanthemi Indici 100g, Herba Houttuyniae 100g, Radix Bupleuri 200g, Mentholum 0.5g, Borneolum Syntheticum 1g, carboxymethyl starch sodium 10g, pregelatinized Starch 3g, Icing Sugar 3g.
2, method for preparing:
1) Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add an amount of the immersion after 4 hours of water and carries out vapor distillation, collect the about 600ml of distillate, and is subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil, carboxymethyl starch sodium 10g, pregelatinized Starch 3g, Icing Sugar 3g according to the equivalent method of progressively increasing again, granulation, granulate, tabletting promptly get.
3, specification: contain crude drug 0.50g/ sheet.
Experimental example: effect experiment
This product directly gets into clinical use through doctor formula, without zoopery.
1, clinical data
1.1 diagnostic criteria is formulated with reference to high medical college teaching material " otolaryngology ", " otolaryngology book series pharyngology ": pharyngalgia, odynophagia; Tonsil and palatoglossal arch hyperemia, swelling, crypts mouth have yellow-white pus point.Heating.
1.2 physical data
Clinical data: select acute tonsillitis patient 85 examples altogether.Male's 47 examples, women's 38 examples.Minimum 4 years old of age, maximum 42 years old.Mean age, (X ± S) was 18.97 ± 9.10 years old.The course of disease was less than 3 days.Two groups of patients are checking through harmony aspect age, sex and the course of disease,
2, method
2.1 select pharyngalgia, odynophagia, tonsil hyperemia, swelling, fever patient's 35 examples.
Be divided into two groups at random by the prescription on individual diagnosis order:
Matched group 53 examples give general conventional therapy (independent or Combined application such as Compound recipe Radix Isatidis sheet, Amoxicillin Capsules, paracetamol tablet), 3 days courses of treatment.
Treatment group 85 examples are treated with the Jinhua oil spray that embodiment 1 makes, and spray in the oral cavity, sucks, and sprays every day 3 times, 5 days courses of treatment 2 times at every turn.
Observing clinical symptoms and sign changes: comprise traditional Chinese medical science disease, pharyngalgia, odynophagia, tonsil hyperemia, swelling, heating.
2.2 statistical method:
Adopt SPSS forWindows 10.0.7 statistical package, enumeration data adopts the x2 check, and ranked data adopt Ridit to analyze, and measurement data adopts the t check.
3, criterion of therapeutical effect:
People's Republic of China's Chinese medicine industry standard " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " with reference to State Administration of Traditional Chinese Medicine's issue:
Cure: pharyngeal transference cure, tonsil are not congested, the no pus point.
Take a turn for the better: pharyngeal sx, tonsil pus point is eliminated.
Do not heal: sings and symptoms does not have obvious improvement.
4, experimental result:
4.1 clinical symptoms:
Before the treatment, clinical symptoms of different degrees appears in the patient, mainly shows as pharyngalgia, odynophagia, congested, the heating of tonsil.Through treatment, symptom is greatly improved, and the doing well,improving rate of treatment group is high than matched group.
Table 1: two groups of clinical symptoms are improved relatively
From clinical comprehensive therapeutic effect, treatment is organized in 85 examples, produce effects 69 examples, and effective 11 examples, invalid 5 examples, total effective rate is 94.00%; In matched group 53 examples, produce effects 35 examples, effective 12 examples, invalid 6 examples, total effective rate 88.68%.
Clinical total effective rate compares between two groups, and difference has statistical significance (P＜0.05), specifically relatively sees table 2.
Table 2: the clinical comprehensive therapeutic effect of treatment group and matched group is (n) relatively
| Group | Total number of persons | Produce effects | Effectively | Invalid | Effective percentage (%) |
| Matched group | 53 | 37 | 10 | 6 | 88.68 |
| The treatment group | 85 | 69 | ll | 5 | 92.00 |
4.2 untoward reaction:
In therapeutic process, do not find the capsular obvious adverse reaction of digestion, to blood, routine urinalysis, electrocardiogram, hepatic and renal function are checked, all do not see influence.
4.3 the buccal tablet that spray that embodiment 2-4 is made with appearance and embodiment 5 make is treated, the effect of effect and embodiment 1 is similar.
5, conclusion: visible Chinese medicine composition of the present invention and preparation thereof have the effect of treatment laryngopharynx swelling and pain, can effectively treat the also symptom of pharyngalgia, odynophagia, tonsil hyperemia and heating.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (10)
1. a Chinese medicine composition of treating laryngopharynx swelling and pain is characterized in that, this Chinese medicine composition contains following parts by weight of Chinese traditional medicine: Flos Lonicerae 50-200 part; Flos Chrysanthemi Indici 50-200 part; Herba Houttuyniae 50-200 part, Radix Bupleuri 50-200 part, Mentholum 0.1-5 part and Borneolum Syntheticum 0.05-5.0 part.
2. Chinese medicine composition according to claim 1 is characterized in that, this Chinese medicine composition contains following parts by weight of Chinese traditional medicine: Flos Lonicerae 100-150 part; Flos Chrysanthemi Indici 100-150 part; Herba Houttuyniae 100-150 part, Radix Bupleuri 100-150 part, Mentholum 0.5-3 part and Borneolum Syntheticum 0.1-1.0 part.
3. Chinese medicine composition according to claim 2 is characterized in that, this Chinese medicine composition contains following parts by weight of Chinese traditional medicine: 125 parts of Flos Loniceraes, 125 parts of Flos Chrysanthemi Indicis, 125 parts of Herba Houttuyniae, 125 parts of Radix Bupleuri, 0.5 part of 1 part of Mentholum and Borneolum Syntheticum.
4. according to each described Chinese medicine composition of claim 1-3, it is characterized in that also contain eucalyptus oil in this Chinese medicine composition, the gross weight of Chinese medicine and the volume ratio g of eucalyptus oil: ml are 200-500: 1-10, are preferably 200-300: 1-2.
5. contain the preparation that right requires each said Chinese medicine composition of 1-4, it is characterized in that, said preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier or excipient.
6. preparation according to claim 5 is characterized in that, said preparation is solid or liquid preparation, and solid preparation is sheet, capsule, granule or spray, and said solid preparation is preferably buccal tablet, spray; Liquid preparation is an oral liquid.
7. preparation according to claim 6 is characterized in that, said preparation is a spray, is made up of Chinese medicine composition and tween 80.
8. preparation according to claim 7 is characterized in that, this spray is grouped into by the one-tenth of following weight portion: Chinese medicine 500-1000g and tween 80 30-100g form.
9. a method for preparing each said preparation of claim 5-8 is characterized in that, this method may further comprise the steps:
1) above seven flavors, Flos Lonicerae, Flos Chrysanthemi Indici, Herba Houttuyniae, Radix Bupleuri add water and soak in right amount after 3-8 hour and carry out vapor distillation, collect the about 600-1000ml of distillate, and are subsequent use;
2) Mentholum, Borneolum Syntheticum are dissolved with small amount of ethanol, add eucalyptus oil and pharmaceutically acceptable carrier or excipient then, be prepared into preparation according to conventional method.
10. each said Chinese medicine composition of claim 1-4 or each said preparation of claim 5-8 application in the medicine of preparation treatment laryngopharynx swelling and pain, said laryngopharynx swelling and pain symptom is the symptom of performances such as acute tonsillitis, acute pharyngitis and simple laryngitis or peritonsillar abscess.
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| CN103142733A (en) * | 2013-03-05 | 2013-06-12 | 刘风荣 | Chinese medicine composition for treating upper respiratory infection |
| CN106963813A (en) * | 2017-04-14 | 2017-07-21 | 佛山市海科知识产权交易有限公司 | It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof |
| CN107137540A (en) * | 2017-06-25 | 2017-09-08 | 长沙善道新材料科技有限公司 | It is a kind of to be used to treat Instant Chinese patent medicine tablet of pharyngitis and preparation method thereof |
| CN109331080A (en) * | 2018-11-02 | 2019-02-15 | 云南康创生物医药科技孵化有限公司 | The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection |
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