CN105535386A - Traditional Chinese medicine for treating infantile acute suppurative mastoiditis and preparation method - Google Patents
Traditional Chinese medicine for treating infantile acute suppurative mastoiditis and preparation method Download PDFInfo
- Publication number
- CN105535386A CN105535386A CN201610099719.4A CN201610099719A CN105535386A CN 105535386 A CN105535386 A CN 105535386A CN 201610099719 A CN201610099719 A CN 201610099719A CN 105535386 A CN105535386 A CN 105535386A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- mastic
- chinese medicine
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine for treating infantile acute suppurative mastoiditis and a preparation method. The traditional Chinese medicine is prepared from a chien briggsia herb, plantain lily flowers, an Elodea-like St.John's wort herb, largeflower Gardenia roots, common averrhoa leaves, a shortlobed wormwood herb, Milkvetch roots, bodinier ampelopsis root-barks, a sampson St.John's wort herb, a zeylan pouzolzia herb, a hairy knotweed herb, mirabilite and all-grass of Leafyinvolucre Saussurea. The traditional Chinese medicine has the advantages that the traditional Chinese medicine can be matched with Western medicine antibiotics to jointly treat infantile acute suppurative mastoiditis, effectively improves the cure rate and total effective rate, is free of toxic and side effects and adverse reaction, quick in effect and simple in preparation process and enables the infantile acute suppurative mastoiditis not to easily relapse.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine and preparation method for the treatment of the suppurative mastoiditis of children's acute.
Background technology
Acute festering type mastoiditis is the acute suppurative inflammation of mastoid air cell mucosa and sclerotin thereof, how to be developed by acute suppurative otitis media.Mainly betide pneumatic mastoid, child is common.Primary disease pathogenic bacterium are common with streptococcus pneumoniae, staphylococcus aureus, bacillus pyocyaneus etc.Have mucosa continuous mutually between middle ear mastoidectomy, after middle ear suppurative infection, mastoid process mucosa also should have inflammatory reaction mutually, and from the beginning of being mucositis inflammatory, may there be mild tenderness mastoid region, and after the perforation of ear drum of waiting is suppurated, mastoid process inflammatory reaction disappears immediately.As evacuation of pus is smooth, or the IIIth type pneumococcal infection, toxicity is very strong, destroys sclerotin, makes mastoid cells myxedema, hemorrhage, downright bad suppuration, just becomes acute festering type mastoiditis.
The otitis media perforation of ear drum suppurate after symptom and sign add severe one on the contrary, mostly be caused by mastoid process infects, Mastoid X-ray photograph films or CT scan, visible mastoid region is muddy or have bone destruction.Mastoid process gasification degree is different, shows and also have difference after inflammation.(1) gasify mastoid process: houselet osteocomma is very thin, be easy to downright bad fusion and form large cavity, be called coalescent mastoiditis, as infected for the stronger Hemolytic streptococcus of toxicity and hemolytic hemophilus influenzae, often cause mucosa blood vessel embolism, hemorrhagic necrosis, houselet is full of courageous and upright secretions, and bone wall does not go to pot, be called hemorrhagic mastoiditis.(2) interstitial type (diplolc type) mastoid process: bone houselet is few, cortex is thicker and have bone marrow structure, forms osteomyelitis, inflammation lingering, because of the easy concurrent intracranial infection of inadequate drainage after infection.(3) atherosclerotic type (hard matter type) mastoid process: houselet is very little, and in Dens Elephatis spline structure, after infection, both not easily drain also not easily forms bone destruction, often causes mucosal tissue hypertrophy, tympanal flaccid part is congested, downright bad, forms gallbladder gallbladder tumor.
Summary of the invention
Technical problem to be solved by this invention is, the Chinese medicine of the suppurative mastoiditis for the treatment of children's acute providing a kind of determined curative effect, toxic and side effects little and preparation method.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of the suppurative mastoiditis of children's acute, described Chinese medicine comprises following raw medicinal material: Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Herba Artemisiae Brachylobae, Radix Astragali, Cortex Ampelopsis Bodinieri Radicis, Herba Hyperici Sampsonii, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Mirabilitum and Herba Saussureae peguensis.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Briggsiae Chienii 20 ~ 30 parts, Flos Hostae Plantagineae 10 ~ 20 parts, Herba hyperici elodeoidis 15 ~ 25 parts, Fructus Gardeniae grandiflorae 20 ~ 30 parts, Folium Averrhoae Carambolae 15 ~ 25 parts, Herba Artemisiae Brachylobae 10 ~ 25 parts, Radix Astragali 15 ~ 25 parts, Cortex Ampelopsis Bodinieri Radicis 20 ~ 30 parts, Herba Hyperici Sampsonii 5 ~ 15 parts, Herba Pouzolziae Zeylanicae 15 ~ 25 parts, Herba Polygoni Barbati 10 ~ 20 parts, Mirabilitum 15 ~ 25 parts and Herba Saussureae peguensis 10 ~ 20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Herba Briggsiae Chienii 20 ~ 25 parts, Flos Hostae Plantagineae 10 ~ 15 parts, Herba hyperici elodeoidis 20 ~ 25 parts, Fructus Gardeniae grandiflorae 25 ~ 30 parts, Folium Averrhoae Carambolae 20 ~ 25 parts, Herba Artemisiae Brachylobae 15 ~ 20 parts, Radix Astragali 15 ~ 20 parts, Cortex Ampelopsis Bodinieri Radicis 25 ~ 30 parts, Herba Hyperici Sampsonii 10 ~ 15 parts, Herba Pouzolziae Zeylanicae 20 ~ 25 parts, Herba Polygoni Barbati 15 ~ 20 parts, Mirabilitum 15 ~ 20 parts and Herba Saussureae peguensis 10 ~ 15 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Briggsiae Chienii 21 parts, Flos Hostae Plantagineae 15 parts, Herba hyperici elodeoidis 22 parts, Fructus Gardeniae grandiflorae 28 parts, Folium Averrhoae Carambolae 21 parts, Herba Artemisiae Brachylobae 19 parts, Radix Astragali 16 parts, Cortex Ampelopsis Bodinieri Radicis 29 parts, Herba Hyperici Sampsonii 11 parts, Herba Pouzolziae Zeylanicae 24 parts, Herba Polygoni Barbati 16 parts, Mirabilitum 19 parts and Herba Saussureae peguensis 12 parts.
The present invention further provides again the preparation method of the Chinese medicine of the suppurative mastoiditis of a kind of above-mentioned treatment children's acute, and the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in proportion, add relative to mixture 4 ~ 7 times amount determining alcohol be 70% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 3 ~ 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, refrigerated storage temperature is 0 DEG C ~ 7 DEG C, and the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
The present invention further provides again the preparation method of the Chinese medicine of the suppurative mastoiditis of a kind of above-mentioned treatment children's acute, and the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, surplus stock medical material is mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, the powder mixing that the first step and second step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.
Beneficial effect of the present invention: Chinese medicine of the present invention, can coordinate the suppurative mastoiditis of western medicine antibiotics co-therapy children's acute, and effectively improve cure rate and total effective rate, have no side effect and untoward reaction, instant effect, not easily recurs, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of the suppurative mastoiditis of children's acute, Chinese medicine comprises following raw medicinal material: Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Herba Artemisiae Brachylobae, Radix Astragali, Cortex Ampelopsis Bodinieri Radicis, Herba Hyperici Sampsonii, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Mirabilitum and Herba Saussureae peguensis.
The pharmacology of various raw medicinal material is as follows:
Herba Briggsiae Chienii: [another name] East China Buddhist, tripe lettuce tongue, rock green vegetable, Fossilia Spiriferis Radix Notoginseng, Herba Melicae Scabrosae, Budgerigar, Rhizoma Seu Herba Bergeniae, little lotus grass.[source] medical material Ji Yuan: be root or the herb of Anhui, Gesneriaceae Zhejiang thick cylinder lettuce tongue.[nature and flavor] mildly bitter flavor; Property is put down.[function cures mainly] expelling pathogenic wind from the body surface; To invigorate blood circulation eliminating carbuncle.Main headache due to common cold; Impairment caused by overstrain; Muscles and bones is ached; Carbuncle skin ulcer; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "
Flos Hostae Plantagineae: [another name] internal diabetes is colored, white crane is colored, white crane is celestial, white calyx, beautiful flower bulb, silver flower only.[source] is come from " product converge with essence want ": Flos Hostae Plantagineae, more than height of seedling chi, and the raw stem end of leaf, light green, six, to put forth difference July, raw number stamen, long two, three cun, delicate fragrance jade-like stone is white, and shape is as hat hairpin, and therefore named Flos Hostae Plantagineae is also.Pod pintongs is made as Semen Iridis, if Ulmus pumila L. and also long and narrow in fact to the autumn.[source] medical material Ji Yuan: be the flower of liliaceous plant Flos Hostae Plantagineae.[nature and flavor] are bitter; Sweet; Cool; Mild toxicity.[function cures mainly] heat-clearing and toxic substances removing; Diuretic; Stimulate the menstrual flow.Main laryngopharynx swelling and pain; Sore, carbuncle and painful swelling; Dysuria; Amenorrhea.[each discussion] 1. " detailed outline is picked up any lost article from the road ": control urinary obstruction.2. " classify herbal ": control seminal emission, spit blood, edema due to disorder of QI, leucorrhea, pharyngitis.3. " south of the Five Ridges gather medicinal herbs record ": lung moistening, cough-relieving blood, mashes with water again, drink can separate Mylabris poison.4. " Hebei medical material ": tire is pregnant absolutely, loose toxic swelling.5. " Chongqing medical herbs ": regulating QI, invigorate blood circulation, tonify deficiency.Control red collapsing, leucorrhea.[extracts] " China's book on Chinese herbal medicine "
Herba hyperici elodeoidis: [another name] littleization blood, little chemical medicine, Formica fusca grass, little Hypericum beanii, Herba Hyperici Japonici, measles grass, Fel Mylopharyngodon piceus, Herba hedyotis costatae, Herba Hyperici Japonici, Herba Cynanchi Hancockiani, loose, the large Herba Hyperici Japonici of thousand hammers, ant medicine, Radix Indigoferae hancockii, poisonous snake grass.[source] medical material Ji Yuan: be the herb of Garcinia maingayii Herba hyperici elodeoidis, very stem Herba hyperici elodeoidis.[nature and flavor] tremble with fear; Bitter; Puckery.[return through] large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Antidiarrheal.Main infantile whitish aphthae; Infantile pneumonia; Stomatitis; Mastalgia; Impetigo; Venom; Diarrhoea; Chronic dysentery.[extracts] " China's book on Chinese herbal medicine "
Fructus Gardeniae grandiflorae: [another name] volt corpse Fructus Gardeniae, Fructus Gardeniae grandiflorae, yellow dustpan, Semen Pittospori Glabrati, gingival cyst of mucous gland in the newborn Cape jasmine, Fructus Gardeniae grandiflorae, Yellow Fructus Gardeniae, little Fructus Gardeniae.[source] medical material Ji Yuan: be the fruit of dicotyledon medicine Maguireothamnus speciosus Flos Caryophylli Fructus Gardeniae.[nature and flavor] are bitter; Cold.[return through] heart; Liver Channel.[function cures mainly] heat radiation removing toxic substances; Reducing swelling and alleviating pain.Main pyretic toxicity; Jaundice; Epistaxis; Oedema due to nephritis; Contusion is sprained.[extracts] " China's book on Chinese herbal medicine "
Folium Averrhoae Carambolae: [source] medical material Ji Yuan: be the leaf of medicine Oxalidaceae plant Fructus Averrhoae Carambolae.Gather and store: the whole year all can gather, using fresh herb or dry.[nature and flavor] puckery; Bitter; Cold in nature.[return through] liver; Spleen channel.[function cures mainly] expelling wind and removing dampness; Heat-clearing and toxic substances removing; Pain relieving.Main anemopyretic cold; Dysuria; Puerperal edema; Swollen ulcer drug; Dermatitis rhus; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Artemisiae Brachylobae: [another name] camel Artemisia.[source] medical material Ji Yuan: be the herb of feverfew mountain Artemisia.Gather and store: summer, autumn gather, and remove earth, dry.[nature and flavor] acrid in the mouth; Bitter; Property is put down.[function cures mainly] expelling wind and removing dampness; Clearing heat for detumescence.Main air pain of dampness syndrome; Pain is closed in polarization; Laryngopharynx swelling and pain.[extracts] " China's book on Chinese herbal medicine "
Radix Astragali: [another name] wears crushed grain (" herbal classic "), wear mulberry, solely mulberry, another name for Sichuan Province fat, hundred (" not Lu "), Rhizoma Paridis tetraphyllae's (" property of medicine opinion "), hundred medicine silk flosses (Hou Ningji " medicine spectrum "), continuous Radix Astragali (" Bencao Tujing "), the Radix Astragali (" detailed outline "), arrow stilbene (Liu Shilian " medical science is integrated "), soil quick-fried of mountain root (" Xinjiang medical material "), only son and heir's (" Gansu Chinese medicine handbook "), two people lift (" Liaoning economic plants will ").[source] is the dry root of leguminous plant Radix Astragali or Inner Mongol Radix Astragali etc.Autumn excavates.Ex-all earth, cuts root head and supporting root, dries rear bundling respectively.Or shine to six, seventy percent dry, be bundled into wisp, then dry.[nature and flavor] are sweet, tepor.[return through] enters lung, spleen channel.[function cures mainly] is raw to be used: benefit defends consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting.Control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and do not hold back for a long time.Process use: invigorating the spleen and replenishing QI.Control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, gas tiger blood prostration, metrorrhagia and leukorrhagia, and the card of all weakness of QI blood deficiency.[extracts] " Chinese medicine voluminous dictionary "
Cortex Ampelopsis Bodinieri Radicis: [another name] Radix seu folium Gaultheriae intermediae, Cortex Ampelopsis Aconitifoliae Radicis.[source] medical material Ji Yuan: be the root bark of vitaceae blue fruit Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae).[nature and flavor] acid; Puckery; Micro-pungent; Flat.[return through] liver; Kidney channel.[function cures mainly] expelling wind and removing dampness; Dissipating blood stasis stops blooding.Main air pain of dampness syndrome; Hemostagnant metrorrhagia; Traumatic injury.[each discussion] " Shaanxi Chinese herbal medicine ": subduing swelling and detoxicating, hemostasis and pain-relieving, evacuation of pus life, wind-damp dispelling.Control traumatic injury, fracture, rheumatic arthritis, rheumatic lumbago and scelalgia, has blood in stool, metrorrhagia, leucorrhea.[extracts] " China's book on Chinese herbal medicine "
Herba Hyperici Sampsonii: [another name] yearning between lovers, lamp-stand, pairing conjunction, Herba leonuri pseudoma cranthi, great Ye boil on the nape opposite the mouth lotus, punching arrow, Herba lysimachiae capillipedis, to through grass, boil on the nape opposite the mouth lotus, Herba Artemisiae Anomalae, bell perfume, Herba Cynanchi Hancockiani, Serpentis sharp edge of broken glass, to the moon lotus, Herba Canscorae, red without treasured, sharp JINHUA, Semen Vaccariae, large first sow perfume, Ye Baozhi, Herba Hyperici, pagoda grass, Serpentis opening, big sub-grass, wild tobacco, cry that pearl grass, careless, the fine dragonfly of the sub-grass of nebula, rotten intestinal are careless, Herba Artemisiae Anomalae, whistle grass, Radix Ardisiae Punctatae, yellow leaf Fructus Forsythiae, Candle desk lamp greatly.[source] is come from " Bencao Congxin "." detailed outline is picked up any lost article from the road ": Herba Hyperici Sampsonii has two kinds, a kind of two leaf phimosis, also DUIJIESHENG; A kind of solely leaf, stem wears the leaf heart.Be used as medicine with only leaf person for victory.[source] medical material Ji Yuan: be the herb of Garcinia maingayii Herba Hyperici Sampsonii.Gather and store: summer, autumn gather, cleaning, dry or using fresh herb.[nature and flavor] are bitter; Pungent; Cold.[return through] liver; Spleen channel.[function cures mainly] cooling blood for hemostasis; Heat-clearing and toxic substances removing; Promoting blood flow to regulate menstruation; Dispelling wind and removing obstruction in the collateral.Main haematemesis; Spitting of blood; Epistaxis; Stranguria with blood; Menoxenia; Dysmenorrhea; Leucorrhea; Traumatic injury; Rheumatic arthralgia; Lumbago and skelalgia; External also can control tinea capitis; Aphtha; Corneal nebula.[extracts] " China's book on Chinese herbal medicine "
Herba Pouzolziae Zeylanicae: [another name] dissipate, pus see disappear, feed pus cream, field potato, stone potato, Debregeasia orientalis C. J. Chen seedling, cream of drawing out the pus, SHANSHEN, Oryza glutinosa hill covered with grass three eggplant, raw meat medicine.[source] medical material Ji Yuan: for contrayerva fog band root is very removed from office entirely.[nature and flavor] are sweet; Light; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Clear swollen evacuation of pus; Relieving stranguria by diuresis.Main pyogenic skin infection and carbuncle-abscess; Acute mastitis; Acute toothache; Dysentery; Diarrhoea; Urine leaching pain; Nebulousurine.[extracts] " China's book on Chinese herbal medicine "
Herba Polygoni Barbati: [another name] little Herba Polygoni gracilis, Herba Polygoni gracilis, smartweed, Herba Commelinae Bengalensis, little Mao grass, willow spicy, red stalk grass, spinelet Herba Polygoni Barbati, Rhizoma et radix valerianae.[source] medical material Ji Yuan: be the herb of polygonaceae plant Herba Polygoni Barbati.[nature and flavor] are pungent; Warm in nature.[function cures mainly] heat-clearing and toxic substances removing; Evacuation of pus granulation promoting; Invigorate blood circulation; Rash.Main fever caused by exogenous pathogens; Throat moth; Chronic malaria; Dysentery; Have loose bowels; Carbuncle; Cellulitis; Fistula; Scrofula diabrosis is not held back, snake bite and insect sting; Traumatic injury; Rheumatic arthralgia; Measles does not lure.[extracts] " China's book on Chinese herbal medicine "
Mirabilitum: [another name] Mirabilitum stone, Sal Nitri Piao, Hai Mo, Mirabilitum, skin disappears, salt disappears, water disappears, extra large skin disappears, hair disappears.[source] medical material Ji Yuan: for Sulfates Natrii Sulfas talks about the semifinished product of mineral nitre or artifact Natrii Sulfas.[nature and flavor] are pungent; Bitter salty; Cold.[return through] stomach; Large intestine channel.[function cures mainly] is purged heat and is moisturized; Clearing heat for detumescence; Hard masses softening and resolving.Main excess-heat stagnates; Abdominal distention constipation; Retention of phlegm gathers; Conjunctival congestion and swelling pain; Sore throat; Carbuncle; Swelling of the breast; Swelling and pain of hemorrhoid; Retention of phlegm gathers; Married woman's abdominal pain due to blood stasis.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Herba Saussureae peguensis: [another name] Artemisia branch, black powder, cockscomb are joined; HERBA CIRSII.[source] medical material Ji Yuan: be root and the herb of feverfew leaf head hieracioides.[nature and flavor] sweet in the mouth; Bitter; Cold nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxicity for eliminating carbuncles.Main lung-heat cough with asthma; Jaundice due to damp-heat; Carbuncle; Venom.[each discussion] " Xinhua's book on Chinese herbal medicine outline ": herb or root: sweet in the mouth, hardship, cold nature.There is the function of nourishing, heat-clearing and toxic substances removing, anti-inflammation hemostasia.For hepatitis, giddy, night sweat, puerperal asthenia, edema, outward for venom.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can more preferably: Herba Briggsiae Chienii 20 ~ 30 parts, Flos Hostae Plantagineae 10 ~ 20 parts, Herba hyperici elodeoidis 15 ~ 25 parts, Fructus Gardeniae grandiflorae 20 ~ 30 parts, Folium Averrhoae Carambolae 15 ~ 25 parts, Herba Artemisiae Brachylobae 10 ~ 25 parts, Radix Astragali 15 ~ 25 parts, Cortex Ampelopsis Bodinieri Radicis 20 ~ 30 parts, Herba Hyperici Sampsonii 5 ~ 15 parts, Herba Pouzolziae Zeylanicae 15 ~ 25 parts, Herba Polygoni Barbati 10 ~ 20 parts, Mirabilitum 15 ~ 25 parts and Herba Saussureae peguensis 10 ~ 20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Herba Briggsiae Chienii 20 ~ 25 parts, Flos Hostae Plantagineae 10 ~ 15 parts, Herba hyperici elodeoidis 20 ~ 25 parts, Fructus Gardeniae grandiflorae 25 ~ 30 parts, Folium Averrhoae Carambolae 20 ~ 25 parts, Herba Artemisiae Brachylobae 15 ~ 20 parts, Radix Astragali 15 ~ 20 parts, Cortex Ampelopsis Bodinieri Radicis 25 ~ 30 parts, Herba Hyperici Sampsonii 10 ~ 15 parts, Herba Pouzolziae Zeylanicae 20 ~ 25 parts, Herba Polygoni Barbati 15 ~ 20 parts, Mirabilitum 15 ~ 20 parts and Herba Saussureae peguensis 10 ~ 15 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Briggsiae Chienii 21 parts, Flos Hostae Plantagineae 15 parts, Herba hyperici elodeoidis 22 parts, Fructus Gardeniae grandiflorae 28 parts, Folium Averrhoae Carambolae 21 parts, Herba Artemisiae Brachylobae 19 parts, Radix Astragali 16 parts, Cortex Ampelopsis Bodinieri Radicis 29 parts, Herba Hyperici Sampsonii 11 parts, Herba Pouzolziae Zeylanicae 24 parts, Herba Polygoni Barbati 16 parts, Mirabilitum 19 parts and Herba Saussureae peguensis 12 parts.
The present invention further provides again the preparation method of the Chinese medicine of the suppurative mastoiditis of a kind of above-mentioned treatment children's acute, and the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in proportion, add relative to mixture 4 ~ 7 times amount determining alcohol be 70% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 3 ~ 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, refrigerated storage temperature is 0 DEG C ~ 7 DEG C, and the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
The present invention further provides again the preparation method of the Chinese medicine of the suppurative mastoiditis of a kind of above-mentioned treatment children's acute, and the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, surplus stock medical material is mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, the powder mixing that the first step and second step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: oral solutions prepared by the present invention
Get Herba Briggsiae Chienii 210g, Flos Hostae Plantagineae 150g, Herba hyperici elodeoidis 220g, Fructus Gardeniae grandiflorae 280g, Folium Averrhoae Carambolae 210g, Herba Artemisiae Brachylobae 190g, Radix Astragali 160g, Cortex Ampelopsis Bodinieri Radicis 290g, Herba Hyperici Sampsonii 110g, Herba Pouzolziae Zeylanicae 240g, Herba Polygoni Barbati 160g, Mirabilitum 190g and Herba Saussureae peguensis 120g.
Its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in proportion, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 3 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 6 times of water gagings, boils 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;
3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, refrigerated storage temperature is 1 DEG C, and the chilling treatment time is 36 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.24; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 30 minutes, and temperature is 105 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
Embodiment 2: prepared by the present invention contains tablet
Get Herba Briggsiae Chienii 240g, Flos Hostae Plantagineae 120g, Herba hyperici elodeoidis 240g, Fructus Gardeniae grandiflorae 260g, Folium Averrhoae Carambolae 250g, Herba Artemisiae Brachylobae 160g, Radix Astragali 180g, Cortex Ampelopsis Bodinieri Radicis 260g, Herba Hyperici Sampsonii 150g, Herba Pouzolziae Zeylanicae 210g, Herba Polygoni Barbati 190g, Mirabilitum 170g and Herba Saussureae peguensis 140g.
Its preparation method comprises the following steps:
The first step, mixes Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis in described ratio, and with the dissolve with ethanol of the determining alcohol 90% of 5 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 4 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, surplus stock medical material is mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 90% of 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, the powder mixing that the first step and second step are obtained, add the carboxymethyl starch sodium of mixture quality 0.07 times, the microcrystalline Cellulose of 0.08 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.03 times obtained, then with decompressor by granule tabletted, obtain containing tablet.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 30-38g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the extract oral liquor prepared by embodiments of the invention 1 is dissolved in water, (concentration is 7.82g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 39.1 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage oral solutions LD50>39.1 crude drug/kg of the present invention, every day, maximum dosage-feeding was 78.2 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.26g crude drug/day/people, adult body weight in 60KG, average dosage is 0.1377g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 34g) oral administration gavage Chinese medicine of the present invention is 568 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 oral solutions of the present invention to three groups of mices (often organize 20) by 13.28,25.32 and 42.47g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: all 98 routine cases all derive from this Out-patient Department and inpatient, and infant is divided into treatment group and matched group at random.Wherein, treatment group 50 example, man 25 example, female 25 example, age 4-12 year, course of disease 3-45h.Matched group 48 example, man 24 example, female 24 example, age 4-12 year, course of disease 3-48h.Treatment group and matched group patient no significant difference in age, sex, the course of disease and the state of an illness, two groups of data comparing difference not statistically significants (P > 0.05), have comparability.
Diagnostic criteria: have upper respiratory tract infection history or injury of tympanic membrane history etc. more; Hearing test is conductive deafness; The visible mastoid air cell of x ray examination is fuzzy, or has necrosis of bone, forms cavity; Conscious in ear pain is aggravated gradually, very then aching as needle stabbing, traction brains, companion's tinnitus, auditory dysesthesia; Heating, attaches most importance to children's; Child patient often has uneasiness of crying and screaming, shakes the head and grab ear; Occasionally can vertigo, nausea,vomiting,diarrhea, or headache stiffness of the nape, spurting vomiting; Inspection is shown in that tympanum is congested, bulge, can swell in mamillary, and after perforation, secretions is that pulsation flows out as beacon shape (beacon is levied).Send out febrile lysis after routed pus, otalgia falls sharply.As being acute mastoiditis person, visible tympanum is congested, should bore a hole and puncherless, or has bored a hole and pus inadequate drainage, and after external auditory meatus, upper wall stays shape, the red and swollen tenderness in mastoid region.Inspection is shown in that tympanum is congested, bulge, can swell in mamillary, and after perforation, secretions is that pulsation flows out as beacon shape (beacon is levied).Send out febrile lysis after routed pus, otalgia falls sharply.As being acute mastoiditis person, visible tympanum is congested, should bore a hole and puncherless, or has bored a hole and pus inadequate drainage, and after external auditory meatus, upper wall stays shape, the red and swollen tenderness in mastoid region.The visible mastoid air cell of x ray examination is fuzzy, or has necrosis of bone, forms cavity.Carry out CT examination if desired.
Therapeutic Method:
Matched group: oral amoxicillin capsule, 0.5g/ time, every day 3 times; The process such as conventional warm-down, drain; There are vomiting, diarrhoea person, suitable fluid infusion should be noted, correct electrolyte disturbance; 7 days courses for the treatment of, treat two courses for the treatment of.
Treatment group: on treatment of control group basis, simultaneously oral Chinese medicine embodiment 1 oral solutions of the present invention, each 20ml, every day 3 times; 7 days courses for the treatment of, treat two courses for the treatment of.
Curative effect judging standard: recovery from illness: the clinical symptom disappearance such as heating, otalgia and ear suppurate transference cure, and auditory rehabilitation is normal, mastoidea skin turgor and tenderness disappearance.Effective: the clinical symptoms such as heating disappear substantially, there is otalgia and ear once in a while and to suppurate symptom, audition significantly improves, and mastoidea skin turgor and tenderness disappear substantially.Take a turn for the better: the clinical symptoms such as heating take a turn for the better to some extent, otalgia and ear symptom of suppurating takes a turn for the better to some extent, and pus amount compares minimizing before treatment, audition be improved but and not obvious, mastoidea skin turgor, has tenderness phenomenon.Invalid: the state of an illness adds severe one without obviously improving or having.
Therapeutic outcome: two groups treat 2 courses for the treatment of respectively after, statistical result is see table 1 and table 2.
Table 1 liang group treats Clinical efficacy comparison (unit: example) after 2 courses for the treatment of respectively
| Group | Number of cases | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 50 | 40 | 6 | 4 | 0 | 50(100％) |
| Matched group | 48 | 31 | 5 | 6 | 6 | 42(87.5％) |
As can be seen from Table 1, relative to matched group, treatment group, on therapeutic effect, has significant improvement.
After a table 2 liang group treats 2 courses for the treatment of respectively, healing number and time compare (unit: example)
| Group | Number of cases | Medication 7 days | Medication 10 days | Medication 14 days |
| Treatment group | 40 | 32(62％) | 35(70％) | 40(80％) |
| Matched group | 31 | 17(35.4％) | 24(50％) | 31(64.6％) |
As can be seen from Table 2, relative to matched group, treatment group is better efficacy not only, takes effect also faster.
Relapse rate is added up: the 31 routine patients that the 40 routine patients cure treatment group and matched group are cured follow up a case by regular visits to 3 months respectively, and result is added up, and treatment group is without recurrence, and relapse rate is 0%; Matched group, recurs 3 people, relapse rate 9.68%.
Untoward reaction: the routine patient of matched group 48, in therapeutic process, there is the gastrointestinal upset such as nausea,vomiting,diarrhea in 5 examples, and erythra appears in 2 examples, all do not occur hepatic and renal function injure or other untoward reaction., in therapeutic process, all there is not hepatic and renal function injure, gastrointestinal reaction or other untoward reaction in the routine patient for the treatment of group 50.
Concrete case: infant Zhang, women, 7 years old, before 4 days because of otalgia, suppurate to other hospital admissions, being diagnosed as acute suppurative otitis media, slightly taking a turn for the better after treatment, increasing because suppurating suddenly, heating etc., transfer from one hospital to another to the court and see a doctor, carrying with the case history of other hospitals and x-ray, to take the photograph sheet for reference, carries out CT examination display: right mastoid process is diplolc type, mastoid air cell increase in density, interval increases thick, tegmen tympani and sigmoid sinus antetheca sclerotin complete, have no destruction, attic, aditus ad antrum and mastoid antrum slightly expand, and osteosclerosis is shown in by bone wall; Left mastoid process is pneumatic type, and the gasification of gas room is good, and interval is clear, and attic, aditus ad antrum and mastoid antrum are normally clear, has no osteosclerosis or destruction.Be diagnosed as through clinical health check-up and CT examination etc.: right side acute festering type features of chronic otitis media.Oral amoxicillin capsule, 0.5g/ time, every day 3 times; The process such as Typical physical cooling, drain; Oral Chinese medicine embodiment 1 oral solutions of the present invention simultaneously, each 20ml, every day 3 times; After taking 10 days, the clinical symptom disappearance such as heating, otalgia and ear suppurate transference cure, and auditory rehabilitation is normal, and mastoidea skin turgor and tenderness disappear, and clinical diagnosis is fully recovered.Follow up a case by regular visits to 3 months without recurrence.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat the Chinese medicine of the suppurative mastoiditis of children's acute for one kind, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Herba Artemisiae Brachylobae, Radix Astragali, Cortex Ampelopsis Bodinieri Radicis, Herba Hyperici Sampsonii, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Mirabilitum and Herba Saussureae peguensis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Briggsiae Chienii 20 ~ 30 parts, Flos Hostae Plantagineae 10 ~ 20 parts, Herba hyperici elodeoidis 15 ~ 25 parts, Fructus Gardeniae grandiflorae 20 ~ 30 parts, Folium Averrhoae Carambolae 15 ~ 25 parts, Herba Artemisiae Brachylobae 10 ~ 25 parts, Radix Astragali 15 ~ 25 parts, Cortex Ampelopsis Bodinieri Radicis 20 ~ 30 parts, Herba Hyperici Sampsonii 5 ~ 15 parts, Herba Pouzolziae Zeylanicae 15 ~ 25 parts, Herba Polygoni Barbati 10 ~ 20 parts, Mirabilitum 15 ~ 25 parts and Herba Saussureae peguensis 10 ~ 20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Briggsiae Chienii 20 ~ 25 parts, Flos Hostae Plantagineae 10 ~ 15 parts, Herba hyperici elodeoidis 20 ~ 25 parts, Fructus Gardeniae grandiflorae 25 ~ 30 parts, Folium Averrhoae Carambolae 20 ~ 25 parts, Herba Artemisiae Brachylobae 15 ~ 20 parts, Radix Astragali 15 ~ 20 parts, Cortex Ampelopsis Bodinieri Radicis 25 ~ 30 parts, Herba Hyperici Sampsonii 10 ~ 15 parts, Herba Pouzolziae Zeylanicae 20 ~ 25 parts, Herba Polygoni Barbati 15 ~ 20 parts, Mirabilitum 15 ~ 20 parts and Herba Saussureae peguensis 10 ~ 15 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Briggsiae Chienii 21 parts, Flos Hostae Plantagineae 15 parts, Herba hyperici elodeoidis 22 parts, Fructus Gardeniae grandiflorae 28 parts, Folium Averrhoae Carambolae 21 parts, Herba Artemisiae Brachylobae 19 parts, Radix Astragali 16 parts, Cortex Ampelopsis Bodinieri Radicis 29 parts, Herba Hyperici Sampsonii 11 parts, Herba Pouzolziae Zeylanicae 24 parts, Herba Polygoni Barbati 16 parts, Mirabilitum 19 parts and Herba Saussureae peguensis 12 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in proportion, add relative to mixture 4 ~ 7 times amount determining alcohol be 70% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 3 ~ 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, refrigerated storage temperature is 0 DEG C ~ 7 DEG C, and the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, surplus stock medical material is mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, the powder mixing that the first step and second step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.
7. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in proportion, add relative to mixture 4 ~ 7 times amount determining alcohol be 70% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 3 ~ 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, refrigerated storage temperature is 0 DEG C ~ 7 DEG C, and the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
8. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Flos Hostae Plantagineae, Herba hyperici elodeoidis, Fructus Gardeniae grandiflorae, Folium Averrhoae Carambolae, Mirabilitum and Herba Saussureae peguensis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, surplus stock medical material is mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, the powder mixing that the first step and second step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610099719.4A CN105535386A (en) | 2016-02-23 | 2016-02-23 | Traditional Chinese medicine for treating infantile acute suppurative mastoiditis and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610099719.4A CN105535386A (en) | 2016-02-23 | 2016-02-23 | Traditional Chinese medicine for treating infantile acute suppurative mastoiditis and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105535386A true CN105535386A (en) | 2016-05-04 |
Family
ID=55815296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610099719.4A Pending CN105535386A (en) | 2016-02-23 | 2016-02-23 | Traditional Chinese medicine for treating infantile acute suppurative mastoiditis and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105535386A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920413A (en) * | 2016-06-19 | 2016-09-07 | 柳春华 | Traditional Chinese medicine for treating juvenile bronchial pneumonia and method of preparation for same |
| CN105943975A (en) * | 2016-07-01 | 2016-09-21 | 周茂军 | Traditional Chinese medicine for treating breast cystic hyperplasia and preparation method thereof |
| CN113521009A (en) * | 2021-06-29 | 2021-10-22 | 徐艳华 | Granules for relieving sore throat and eliminating phlegm and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147575A (en) * | 2014-08-27 | 2014-11-19 | 刘德学 | Traditional Chinese medicine preparation for treating wind-cold lung-closure-type chronic bronchitis and preparation method thereof |
-
2016
- 2016-02-23 CN CN201610099719.4A patent/CN105535386A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147575A (en) * | 2014-08-27 | 2014-11-19 | 刘德学 | Traditional Chinese medicine preparation for treating wind-cold lung-closure-type chronic bronchitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 田道法: "《耳鼻咽喉科中西医诊疗套餐》", 30 September 2013, 人民军医出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920413A (en) * | 2016-06-19 | 2016-09-07 | 柳春华 | Traditional Chinese medicine for treating juvenile bronchial pneumonia and method of preparation for same |
| CN105943975A (en) * | 2016-07-01 | 2016-09-21 | 周茂军 | Traditional Chinese medicine for treating breast cystic hyperplasia and preparation method thereof |
| CN113521009A (en) * | 2021-06-29 | 2021-10-22 | 徐艳华 | Granules for relieving sore throat and eliminating phlegm and preparation process thereof |
| CN113521009B (en) * | 2021-06-29 | 2022-12-23 | 徐艳华 | Granules for relieving sore-throat and eliminating phlegm and preparation process thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105535386A (en) | Traditional Chinese medicine for treating infantile acute suppurative mastoiditis and preparation method | |
| CN104888011A (en) | Traditional Chinese medicine capsule for treating pneumonia and preparation method of traditional Chinese medicine capsule | |
| CN103356802B (en) | Medicament for treating mastitis, and preparation method thereof | |
| CN106267028A (en) | A kind of Chinese medicine composition treating pneumonia and preparation method thereof | |
| CN105381104A (en) | Traditional Chinese medicine for treating child acute suppurative otomastoiditis and preparing method | |
| CN108498649B (en) | Scorpion-astragalus root ointment | |
| CN105031065A (en) | Traditional Chinese medicine for treating acute suppurative otitis media and preparation method of traditional Chinese medicine | |
| CN106237206A (en) | A kind of Chinese medicine preparation treating tumor and preparation method thereof | |
| CN105943639A (en) | Traditional Chinese medicine composition assisting in treating chronic subdural hematoma | |
| CN105726969A (en) | Traditional Chinese medicine for treating acute radiation pneumonitis and preparation method of traditional Chinese medicine | |
| CN105998781A (en) | Pharmaceutical composition for treating acute gastroenteritis | |
| CN105168847A (en) | Traditional Chinese medicine for treating helicobacter pylori infected peptic ulcer | |
| CN105412560A (en) | Medicine for treating common cold and preparation method thereof | |
| CN105412679A (en) | Traditional Chinese medicine preparation for treating lung abscess and preparation method thereof | |
| CN117379510A (en) | Oral medicinal liquor and preparation method thereof | |
| CN113456790A (en) | Lung clearing soup for preventing lung diseases | |
| CN103393973B (en) | Chinese medicinal composition for treating rhinitis | |
| CN103877425A (en) | Chinese medicinal composition as well as preparation method and application thereof | |
| CN115944692A (en) | A pharmaceutical composition for treating common cold and preparation method thereof | |
| CN112516241A (en) | Pharmaceutical composition for treating nasopharyngeal carcinoma and application thereof | |
| CN105832901A (en) | Traditional Chinese medicine preparation for treating acute pancreatitis and preparation method thereof | |
| CN107714983A (en) | A kind of medicine for treating chronic pharyngitis and preparation method thereof | |
| CN107823424A (en) | A kind of Chinese medicine composition for treating chronic pharyngitis and preparation method thereof | |
| CN107468920A (en) | A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction | |
| CN106267111A (en) | A kind of Chinese medicine composition treating mastitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160504 |