CN105943975A - Traditional Chinese medicine for treating breast cystic hyperplasia and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating breast cystic hyperplasia and a preparation method thereof. The traditional Chinese medicine comprises the following Chinese herbal medicines of herb of argun groundsel, dracocephalum rupestre hance, haloragis micrantha, flower of operculate cleistocalyx, glycosmis pentaphylla, rhaphidophora decursiva, patience dock root, red-knees herb, sowthistle tasselflower herb, glomeris nipponica kishida, lindera communis, rubus parvifolius, bridal wreath, polygala japonica, caulis et folium plucheae, sparganium stoloniferum, ludwigia hyssopifo-lia (G.Don) exekk and root of emblic leafflower. The traditional Chinese medicine has the beneficial effects that by combining with the conventional western medicine method, the breast cystic hyperplasia can be treated; the convenience in use is realized, the treatment effect is effectively improved, the effective rate and curative rate are increased, any toxic or side effect is avoided, the treatment effect is quick, the easiness in reoccurrence is avoided after recovery, the adverse effect of western medicines is reduced, and the preparation technology is simple.

Description

A kind of Chinese medicine treating cystic cyclomastopathy and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of cystic cyclomastopathy for the treatment of Chinese medicine and preparation method thereof.

Background technology

Cystic cyclomastopathy (disease of the breast cystic hyperplasia, BCH) Be with lobules of mammary gland, ductule and Song Portugal duct height expansion and formed with cyst as principal character, with Time with the disease of some other dysplasia pathological changes.This disease hypertrophy, atypical hyperplasia coexist, and there is evil The danger become.Cystic hyperplasia disease is entirely pathologic, and Histological change is irreversible.Cyclomastopathy is breast Cystic glandular hyperplasia disease refers to that breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and breast lobule are in structure On degeneration and the growth of Progressive symmetric erythrokeratodermia connective tissue, its pathogenic factor mainly due to endocrine swash Element imbalance.Cystic cyclomastopathy disease is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for mastopathy First place.This disease sickness rate the most increasingly became younger in the trend risen year by year, age in the last few years.According to Investigation there are about the women of 70%～80% cystic cyclomastopathy in various degree, is more common in 25～45 The women in year.Have a different characteristics in age groups, unmarried female, married do not educate, the woman of not yet suckling Female, its cardinal symptom is distending pain of the breast, can involve bilateral simultaneously, but how to lay particular stress on side.Menstruation foremilk Gland distending pain is obvious, i.e. sees and alleviate and taper off after menstruation, and before menstruation next time comes, pain occurs once again, Whole breast has diffusivity tuberosity sense, and with tenderness.After 35 years old, women's cardinal symptom is mammary gland tumor, Breast pain and tenderness are relatively light and unrelated with menstrual cycle.With hands touch breast can touch differ in size, oblate Shape or irregular shape, the tuberosity that quality is pliable and tough, obscure boundary Chu, with skin and deep tissue without adhesion, Can be promoted.The single or multiple Cystic lesions being dispersed in often is shown as after 45 years old, clear border, accompany more There are blunt pain, distending pain or burn feeling.Postmenopausal women's mammary gland atrophy, cystic lesion is the most prominent.Breast The scope non-correlation that has that it's too late of the order of severity of room pain and tuberosity, pain can to oxter, shoulder back puts Dissipate.Small number of patients can occur together nipple discharge.Owing to the cause of disease is from health endocrine dysfunction, therefore except breast It may also occur that menstruation irregularis outside symptom in terms of room simultaneously, have a bad temper, like to worry love anger, like The symptoms such as antiperspirant.

Motherland's medical science thinks the sick generation of breast, the disorder of movement of QI of many duties, therefore method for the treatment of focuses on dredging mechanism of qi, with It is main for regulating the flow of vital energy, and mechanism of qi one is suitable, and all diseases all heal.Tie in occurring stagnation of liver-QI to take advantage of spleen, insufficiency of the spleen caused dampness, breast Network is obstructed；Or pathogenic fire derived from stagnation of liver-QI, perverse and unreasonable manner criminal's stomach, when injuring blood network, expectorant, wet, the stasis of blood will occur in breast , there is the physiological hypertrophy described in doctor trained in Western medicine and subinvolution, shows as breast bulk body of gland, tuberosity in knot mutually Shape body of gland and streak body of gland etc..Expectorant, wet, the stasis of blood tie development further mutually, and caking will be made hardening, The atypical hyperplasia of doctor trained in Western medicine indication is similar with this, either the traditional Chinese medical science or doctor trained in Western medicine, and treatment mammary gland capsule increases Raw disease is required for breaking cystic cyclomastopathy and develops into the trilogy of breast carcinoma, i.e. cystic cyclomastopathy Atypical hyperplasia breast carcinoma.

Summary of the invention

The technical problem to be solved is, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of Determined curative effect and the Chinese medicine for the treatment of cystic cyclomastopathy free of toxic effects and preparation method thereof.

In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating cystic cyclomastopathy, Described Chinese medicine includes following raw medicinal material: Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae, Rubus Parvifolius L., Radix spiraeae prunifoliae, Fructus Cucumidis sativi core Grass, goldenrain tree sweet-scented osmanthus, rhizoma scirpi, grass dragon root and Radix Phyllanthi.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Senecionis Argunensis 20～30 Part, Herba Dracocephali Rupestris 10～20 parts, Herba Haloragidis Micranthae 15～25 parts, Flos Cleistocalycis Operculati 5～15 parts, Radix Glycosmidis Citrifoliae 10～ 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 20～30 parts, Radix Rumicis Patientiae 25～35 parts, Herba polygoni hydropiperis 8～18 parts, Herba Emiliae 10～20 Part, Prospiroboli joannsi 25～30 parts, Cortex Seu Folium Linderae 20～30 parts, Rubus Parvifolius L. 10～20 parts, Radix spiraeae prunifoliae 15～25 Part, Fructus Cucumidis sativi core grass 5～15 parts, goldenrain tree sweet-scented osmanthus 20～30 parts, rhizoma scirpi 15～25 parts, grass dragon root 10～20 Part and Radix Phyllanthi 25～35 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Senecionis Argunensis 25～30 parts, Herba Dracocephali Rupestris 12～17 parts, Herba Haloragidis Micranthae 17～22 parts, Flos Cleistocalycis Operculati 8～13 parts, mountain are little Fructus Citri tangerinae 13～18 parts, Radix Seu Caulis Rhaphidophorae Decursivae 22～27 parts, Radix Rumicis Patientiae 28～33 parts, Herba polygoni hydropiperis 10～15 parts, Radix Rumicis Japonici Grass 15～20 parts, Prospiroboli joannsi 23～28 parts, Cortex Seu Folium Linderae 22～27 parts, Rubus Parvifolius L. 15～20 parts, dimple Spend 20～25 parts, Fructus Cucumidis sativi core grass 9～14 parts, goldenrain tree sweet-scented osmanthus 25～30 parts, rhizoma scirpi 18～23 parts, grass dragon Root 15～20 parts and Radix Phyllanthi 25～30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Senecionis Argunensis 28 parts, Herba Dracocephali Rupestris 13 parts, Herba Haloragidis Micranthae 21 parts, Flos Cleistocalycis Operculati 9 parts, Radix Glycosmidis Citrifoliae 17 parts, Radix Seu Caulis Rhaphidophorae Decursivae 22 parts, Radix Rumicis Patientiae 32 parts, Herba polygoni hydropiperis 11 parts, Herba Emiliae 20 parts, Prospiroboli joannsi 24 parts, Cortex Seu Folium Linderae 26 Part, Rubus Parvifolius L. 16 parts, Radix spiraeae prunifoliae 21 parts, Fructus Cucumidis sativi core grass 13 parts, goldenrain tree sweet-scented osmanthus 26 parts, rhizoma scirpi 22 parts, Grass dragon root 15 parts and Radix Phyllanthi 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Senecionis Argunensis 26 parts, Herba Dracocephali Rupestris 16 parts, Herba Haloragidis Micranthae 18 parts, Flos Cleistocalycis Operculati 12 parts, Radix Glycosmidis Citrifoliae 14 parts, Radix Seu Caulis Rhaphidophorae Decursivae 26 parts, Radix Rumicis Patientiae 30 parts, Herba polygoni hydropiperis 15 parts, Herba Emiliae 16 parts, Prospiroboli joannsi 27 parts, Cortex Seu Folium Linderae 22 Part, Rubus Parvifolius L. 20 parts, Radix spiraeae prunifoliae 24 parts, Fructus Cucumidis sativi core grass 10 parts, goldenrain tree sweet-scented osmanthus 28 parts, rhizoma scirpi 20 parts, Grass dragon root 18 parts and Radix Phyllanthi 27 parts.

When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae and Radix Seu Caulis Rhaphidophorae Decursivae by institute State ratio mixing, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heat back Stream extracts 2～4 times, each reflux, extract, 2 hours～3 hours, and united extraction liquid uses tube centrifuge Centrifugal remove impurity, is evaporated to when 60 DEG C relative under conditions of 60 DEG C～70 DEG C by the extracting solution after remove impurity Density is the medicinal liquid of 1.05～1.10, and the concentrated solution spray dryer after concentrating is dried, and pulverizes subsequently Become 100～200 mesh, it is thus achieved that dry powder；

Second step, by Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae and Rubus Parvifolius L. in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed remainder raw medicinal material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter respectively, Each time filtrate merges, and reclaims ethanol, and when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, It is dried in 55 DEG C～65 DEG C of reduced vacuum, obtains dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～ The water dissolution of 5 times, with 40% sodium hydroxide solution regulation pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 30～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3% or parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

When the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, cattle Cc, Herba polygoni hydropiperis and Herba Emiliae mixing, adding relative to 3 times of mixture～5 times amount determining alcohols is 55%～65% Alcohol reflux 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims second Alcohol, is concentrated into the mastic that 70 DEG C of relative densities are 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum Being dried, get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～ 40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；

5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated, Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is 1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process, Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.

Beneficial effects of the present invention: Chinese medicine of the present invention can Combined with Routine Western Medicine cystic hyperplasia of breast Disease, easy to use, it is effectively improved therapeutic effect, increases effective percentage and cure rate, have no side effect, see Effect is fast, difficulty in relapse after healing, additionally it is possible to reducing the untoward reaction of Western medicine medicine, preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine treating cystic cyclomastopathy, Chinese medicine includes following crude drug Material: Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae, Rubus Parvifolius L., Radix spiraeae prunifoliae, Fructus Cucumidis sativi core grass, goldenrain tree sweet-scented osmanthus, rhizoma scirpi, grass dragon Root and Radix Phyllanthi.

The pharmacology of various raw medicinal materials is as follows:

Herba Senecionis Argunensis: [another name] Herba Senecionis Scandentis, big Herba Artemisiae Sieversianae.[source] medical material Ji Yuan: for feverfew plumage The root of leaf Herba Senecionis Scandentis and herb.[nature and flavor] mildly bitter flavor；Cold in nature.[function cures mainly] heat-clearing and toxic substances removing；Clearly Liver improving eyesight.Main dysentery；Coffee swells and ache；Conjunctival congestion；Carbuncle furuncle；Scrofula；Eczema；Scabies；Poisonous snake stings Wound；Scorpion bee sting.[extracts] " China's book on Chinese herbal medicine "

Herba Dracocephali Rupestris: [source] medical material Ji Yuan: for the herb of labiate Mao Jiancao.[nature and flavor] taste Pungent；Bitter；Cool in nature.[function cures mainly] wind and heat dispersing；Cool liver is stopped blooding.Main anemopyretic cold；Headache；Pharynx Larynx swells and ache；Cough；Jaundice；Dysentery；Spit blood；Epistaxis.[extracts] " China's book on Chinese herbal medicine "

Herba Haloragidis Micranthae: [another name] Semen Sojae Preparatum grass, Radix Berchemiae Yunnanensis, husky SHENGCAO, water Semen Sojae Preparatum, Nasturtium officinale, ant tower, Sand SHENGCAO, stickweed alizarin, white, with red medicine, Strepopelia orientalis nest, deck of boat grass, Pericarpium Zanthoxyli.[source] medical material Ji Yuan: for the herb of Haloragaceae plant Herba Haloragidis Micranthae.[nature and flavor] bitter in the mouth；Puckery；Cool in nature.[return Warp] return lung；Large intestine；Bladder；Nontoxic.[function cures mainly] relieving cough and asthma；Clearing away heat-damp and promoting diuresis；Regulating menstruation is lived Blood.Main cough；Asthma；Pyretic stranguria；Constipation；Dysentery；Menoxenia；Fall damage fracture；Furuncle；Acute mastitis； Scald；Venom.[extracts] " China's book on Chinese herbal medicine "

Flos Cleistocalycis Operculati: [another name] water harmony flower, Radix seu Cortex Heteropanacis Fragrantis.[source] medical material Ji Yuan: plant for Myrtaceae The alabastrum of thing water father-in-law.[nature and flavor] bitter in the mouth；Micro-sweet；Cool in nature.[return through] lung；Spleen；Stomach warp.[merit Can cure mainly] dispel the wind；Induce sweat；Help digestion.Main heat-clearing and toxic substances removing；Drive away summer heat and promote the production of body fluid；Disappear stagnant dampness removing.[extracts] " China's book on Chinese herbal medicine "

Radix Glycosmidis Citrifoliae: [another name] wild husky Citrus chachiensis Hort., meal soup wood, wine cake wood, mountain Phyllanthus emblica L., mountain Fructus Citri tangerinae.[source] Medical material Ji Yuan: for root and the leaf of rutaceae Radix Glycosmidis Citrifoliae.[nature and flavor] are bitter；Flat.[return through] lung； Stomach；Liver Channel.[function cures mainly] expelling pathogenic wind from the body surface；Preventing phlegm from forming and stopping coughing；Regulate the flow of vital energy removing food stagnancy；Dissipating blood stasis for subsidence of swelling.Main sense Emit cough；Dyspepsia is indigestion and loss of appetite；Abdominal pain due to retention of food；Colicky；Treating swelling and pain by traumatic injury is eaten.[extracts] " China's book on Chinese herbal medicine "

Radix Seu Caulis Rhaphidophorae Decursivae: [another name] Cayratia trifolia (L.) Domin, Acer buergerianum Miq．, Malong head lobe, fly Scolopendra, Red Triangle region maple, big Leaf green grapes, little Radix Seu Caulis Rhaphidophorae Decursivae.[source] medical material Ji Yuan: climb rattan and Zhi Nan for vitaceae Folium Trapae precipice Root or the rattan of rattan is climbed on precipice.[nature and flavor] are pungent；Temperature.[function cures mainly] wind-damp dispelling；Dissipating blood stasis swells；Continuous muscle Bone.Main rheumatic arthritis；Traumatic injury congestive edema；Fracture；Burn；Ulcerative carbuncle red and swollen [extracts] " China's book on Chinese herbal medicine "

Radix Rumicis Patientiae: [another name] Radix Rumicis Crispi, cow tongue, open country are rescued greatly, Radix Rumicis Crispi, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), pin Thorn Radix rumicis acetosae, Radix Rumicis, Radix rumicis acetosae root, sheep ferrous acid mould, Radix et Rhizoma Rhei Franzenbachii, ox louse son.[source] medical material base Source: for the root of polygonaceae plant Rumex patientia Linn..[nature and flavor] are bitter；Acid；Cold in nature.[function cures mainly] heat clearing away Removing toxic substances；Hemostasia and detumescence；Relieving constipation；Parasite killing.Main haematemesis；Epistaxis；Have blood in stool；Metrorrhagia；Leucorrhea with red and white discharge；Purple Purplish or white patches on the skin；Dysentery；Hepatitis；Constipation；Dysuria；Ulcerative carbuncle toxic swelling；Scabies；Traumatic injury；Scald fire Wound.[extracts] " China's book on Chinese herbal medicine "

Herba polygoni hydropiperis: [another name] Herba polygoni hydropiperis.[source] Polygonaceae arsesmart Herba polygoni hydropiperis and Herba Polygoni hydropiperis, with herb or Root, leaf are used as medicine.The herb four seasons can adopt, and root and leaf can be adopted at any time, dry.[nature and flavor] are pungent, temperature.[merit Can cure mainly] expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.For dysentery, gastroenteritis, Diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage；Venom is controlled in external, and skin is wet Rash.[extracts] " whole nation Chinese herbal medicine compilation "

Herba Emiliae: [another name] purple, and to carry on the back cabbage mustard careless, false, firecracker grass, Radix seu Folium Alchorneae trewioidis, YEXIAHONG, loudspeaker red Herba Taraxaci careless, little, 72 flowers, oxtail knee joint, purple back of the body Herba Violae japonicae, goatweed, sky hair grass, the colour of loess Even, wild cabbage mustard, milk cylinder list careless, empty, Flos Gomphrenae, purple fourth privately, wild hardship buy, rabbitweed, rabbit ginseng, Crow furuncle grass.[source] medical material Ji Yuan: for herb or the whole herb with root of feverfew Herba Duchesneae Indicae.The whole year can Adopt, using fresh herb or dry.[nature and flavor] bitter in the mouth；Cool in nature.[function cures mainly] heat-clearing and toxic substances removing；Dissipating blood stasis for subsidence of swelling. Your Majesty's respiratory tract infection；Oral ulcer；Pneumonia；Mastitis；Enteritis；Bacillary dysentery；Urinary tract infection；Furuncle Carbuncle；Eczema；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Prospiroboli joannsi: [another name] rolling mountain pearl, arhat.[source] medical material Ji Yuan: move for Glomeridae The entirety of thing glomeris nipponica.[nature and flavor] acrid in the mouth；Salty；Warm in nature.[return through] kidney channel.[function master Control] dispelling wind and removing obstruction in the collateral, eliminating stasis to stop pain.Main air pain of dampness syndrome；Muscle arteries and veins contracture；Traumatic injury；Fracture swells and ache. [extracts] " China's book on Chinese herbal medicine "

Cortex Seu Folium Linderae: [another name] cold and cheerless son, Qian Nianshu, soil Ilicis Purpureae, Oleum sesami fruit, Fructus Pyracanthae leaf, little viscous leaf, Redwood Rhizoma Zingiberis Recens, Rohdea japonica Roth, bright leaf tree, bright leaf perfume, Emmenopterys henryi oliv., Fructus Linderae Glaucae, glutinous leaf tree, spire vacation Camphor tree, Very heavy perfume (or spice), a thousand pieces of gold tree, wild Fructus Litseae pungentis, Cortex Linderae Fragrantis, big Herba Pelargonii Graveolentis, furuncle tree.[source] medical material Ji Yuan: Branch and leaf or peel of stem for canella Cortex Seu Folium Linderae.[nature and flavor] are puckery；Micro-pungent；Cold nature.[return through] lung； Kidney channel.[function cures mainly] removing toxic substances and promoting subsidence of swelling；Eliminating stasis to stop pain；.Main treating swelling and pain by traumatic injury；Traumatic hemorrhage；Carbuncle sore Furuncle and phyma.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Rubus Parvifolius L.: [another name] She Pao, Herba Rubi parvifolii, Fructus Mume disappear, Herba Rubi parvifolii, ull up seedling.[source] Rosaceae rubus Rubus Parvifolius L., is used as medicine with root or stem, leaf.Autumn uproots, Xia Qiucai stem and leaf, fresh With or cutting dry.[nature and flavor] are bitter, puckery, cool.[function cures mainly] clearing away heat and cooling blood, eliminating stagnation, pain relieving, Inducing diuresis to remove edema.For cold, fever, laryngopharynx swelling and pain, spitting of blood, spit blood, dysentery, enteritis, hepatitis, liver Splenomegaly, oedema due to nephritis, urinary system infection, calculus, menoxenia, leucorrhea, rheumatic ostalgia, traumatic injury Swell and ache；Eczema, dermatitis are controlled in external.[extracts] " whole nation Chinese herbal medicine compilation "

Radix spiraeae prunifoliae: [source] medical material Ji Yuan: for the root of rosaceous plant Li Ye Ramulus et Folium Spiraeae Salicifolia.[nature and flavor] Bitter；Cool.[return through] lung meridian.[function cures mainly] relieving sore throat and diminishing swelling, wind-expelling pain-stopping.Main laryngopharynx swelling and pain, Rheumatic arthralgia.[extracts] " China's book on Chinese herbal medicine "

Fructus Cucumidis sativi core grass: [another name] Herba Polygalae Japonicae, Armoracia rusticana (Lam.) P. Gaertner et Sc.[source] medical material Ji Yuan: plant for Polygalaceae The herb of thing knotweedleaf milkwort herb.[nature and flavor] are pungent；Bitter；It is slightly cold.[function cures mainly] dissipating phlegm and resolving masses；Removing toxic substances Detumescence.Main laryngopharynx swelling and pain；Cough chest pain；Cough up phlegm not well；Venom；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Goldenrain tree sweet-scented osmanthus: the miscellaneous tree of [another name] lattice.[source] medical material Ji Yuan: for the stem and leaf of feverfew fetid marsh fleabane Or root.[nature and flavor] sweet in the mouth；Slightly warm in nature.[function cures mainly] warming the stomach goes to amass；Software heavily fortified point eliminating stagnation；Dispel the wind Dehumidifying.Main food stagnation of child；Gall subcutaneous nodule；Rheumatic ostalgia [extracts] " China's book on Chinese herbal medicine "

Rhizoma scirpi: [another name] Rhizoma Sparganii, bubble Rhizoma Sparganii.[source] medical material Ji Yuan: for sedge chaste tree The tuber of Rhizoma Sparganii.[nature and flavor] acrid in the mouth；Bitter；Property flat.[return through] liver；Spleen channel.[function cures mainly] Blood stasis dispelling stimulates the menstrual flow；Removing blood stasis eliminating mass；Circulation of qi promoting removing food stagnancy.Main amenorrhea due to stagnation of blood；Dysmenorrhea；Postpartum stagnation is suffered from abdominal pain；Traumatic injury Congestive edema；Enclosed mass in abdomen；Abdominal pain due to retention of food.[extracts] " China's book on Chinese herbal medicine "

Grass dragon root: [source] medical material Ji Yuan: for the root of onagraceae plant line leaf Herba Ludwigiae Prostratae.[nature and flavor] Bitter in the mouth；Property flat.[function cures mainly] antiasthmatic-antitussive；Removing food stagnancy；Eliminating stagnation.Main asthma；Cough；Infantile malnutrition； Scrofula.[extracts] " China's book on Chinese herbal medicine "

Radix Phyllanthi: [another name] emblic daughter root.[nature and flavor] sweet in the mouth；Micro-hardship；Cool in nature.[return through] liver； Spleen channel.[function cures mainly] clearing away heat-damp and promoting diuresis；Detoxicating and resolving stagnation of pathogens.Master has loose bowels；Dysentery；Jaundice；Scrofula；Skin Skin eczema；Centipete bite.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Senecionis Argunensis 20～30 Part, Herba Dracocephali Rupestris 10～20 parts, Herba Haloragidis Micranthae 15～25 parts, Flos Cleistocalycis Operculati 5～15 parts, Radix Glycosmidis Citrifoliae 10～ 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 20～30 parts, Radix Rumicis Patientiae 25～35 parts, Herba polygoni hydropiperis 8～18 parts, Herba Emiliae 10～20 Part, Prospiroboli joannsi 25～30 parts, Cortex Seu Folium Linderae 20～30 parts, Rubus Parvifolius L. 10～20 parts, Radix spiraeae prunifoliae 15～25 Part, Fructus Cucumidis sativi core grass 5～15 parts, goldenrain tree sweet-scented osmanthus 20～30 parts, rhizoma scirpi 15～25 parts, grass dragon root 10～20 Part and Radix Phyllanthi 25～35 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Senecionis Argunensis 25～30 parts, Herba Dracocephali Rupestris 12～17 parts, Herba Haloragidis Micranthae 17～22 parts, Flos Cleistocalycis Operculati 8～13 parts, mountain are little Fructus Citri tangerinae 13～18 parts, Radix Seu Caulis Rhaphidophorae Decursivae 22～27 parts, Radix Rumicis Patientiae 28～33 parts, Herba polygoni hydropiperis 10～15 parts, Radix Rumicis Japonici Grass 15～20 parts, Prospiroboli joannsi 23～28 parts, Cortex Seu Folium Linderae 22～27 parts, Rubus Parvifolius L. 15～20 parts, dimple Spend 20～25 parts, Fructus Cucumidis sativi core grass 9～14 parts, goldenrain tree sweet-scented osmanthus 25～30 parts, rhizoma scirpi 18～23 parts, grass dragon Root 15～20 parts and Radix Phyllanthi 25～30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Senecionis Argunensis 28 parts, Herba Dracocephali Rupestris 13 parts, Herba Haloragidis Micranthae 21 parts, Flos Cleistocalycis Operculati 9 parts, Radix Glycosmidis Citrifoliae 17 parts, Radix Seu Caulis Rhaphidophorae Decursivae 22 parts, Radix Rumicis Patientiae 32 parts, Herba polygoni hydropiperis 11 parts, Herba Emiliae 20 parts, Prospiroboli joannsi 24 parts, Cortex Seu Folium Linderae 26 Part, Rubus Parvifolius L. 16 parts, Radix spiraeae prunifoliae 21 parts, Fructus Cucumidis sativi core grass 13 parts, goldenrain tree sweet-scented osmanthus 26 parts, rhizoma scirpi 22 parts, Grass dragon root 15 parts and Radix Phyllanthi 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Senecionis Argunensis 26 parts, Herba Dracocephali Rupestris 16 parts, Herba Haloragidis Micranthae 18 parts, Flos Cleistocalycis Operculati 12 parts, Radix Glycosmidis Citrifoliae 14 parts, Radix Seu Caulis Rhaphidophorae Decursivae 26 parts, Radix Rumicis Patientiae 30 parts, Herba polygoni hydropiperis 15 parts, Herba Emiliae 16 parts, Prospiroboli joannsi 27 parts, Cortex Seu Folium Linderae 22 Part, Rubus Parvifolius L. 20 parts, Radix spiraeae prunifoliae 24 parts, Fructus Cucumidis sativi core grass 10 parts, goldenrain tree sweet-scented osmanthus 28 parts, rhizoma scirpi 20 parts, Grass dragon root 18 parts and Radix Phyllanthi 27 parts.

When the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae and Radix Seu Caulis Rhaphidophorae Decursivae by institute State ratio mixing, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heat back Stream extracts 2～4 times, each reflux, extract, 2 hours～3 hours, and united extraction liquid uses tube centrifuge Centrifugal remove impurity, is evaporated to when 60 DEG C relative under conditions of 60 DEG C～70 DEG C by the extracting solution after remove impurity Density is the medicinal liquid of 1.05～1.10, and the concentrated solution spray dryer after concentrating is dried, and pulverizes subsequently Become 100～200 mesh, it is thus achieved that dry powder；

Second step, by Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae and Rubus Parvifolius L. in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed remainder raw medicinal material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter respectively, Each time filtrate merges, and reclaims ethanol, and when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, It is dried in 55 DEG C～65 DEG C of reduced vacuum, obtains dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～ The water dissolution of 5 times, with 40% sodium hydroxide solution regulation pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 30～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3% or parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

When the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, cattle Cc, Herba polygoni hydropiperis and Herba Emiliae mixing, adding relative to 3 times of mixture～5 times amount determining alcohols is 55%～65% Alcohol reflux 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims second Alcohol, is concentrated into the mastic that 70 DEG C of relative densities are 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum Being dried, get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～ 40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；

5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated, Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is 1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process, Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.

Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this Execute.

Embodiment 1: syrup

Take Herba Senecionis Argunensis 260g, Herba Dracocephali Rupestris 160g, Herba Haloragidis Micranthae 180g, Flos Cleistocalycis Operculati 120g, Radix Glycosmidis Citrifoliae 140g, Radix Seu Caulis Rhaphidophorae Decursivae 260g, Radix Rumicis Patientiae 300g, Herba polygoni hydropiperis 150g, Herba Emiliae 160g, Prospiroboli joannsi 270g, Cortex Seu Folium Linderae 220g, Rubus Parvifolius L. 200g, Radix spiraeae prunifoliae 240g, Fructus Cucumidis sativi core grass 100g, goldenrain tree sweet-scented osmanthus 280g, rhizoma scirpi 200g, Grass dragon root 180g and Radix Phyllanthi 270g.

Its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae and Radix Seu Caulis Rhaphidophorae Decursivae by institute State ratio mixing, add the ethanol that determining alcohol is 90% relative to 5 times of mixture, heating and refluxing extraction 4 Secondary, each reflux, extract, 2 hours, united extraction liquid, it is centrifuged remove impurity with tube centrifuge, after remove impurity Extracting solution when being evaporated to 60 DEG C under conditions of 65 DEG C relative density be the medicinal liquid of 1.08, by dense Concentrated solution spray dryer after contracting is dried, and is ground into 200 mesh subsequently, it is thus achieved that dry powder；

Second step, by Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae and Rubus Parvifolius L. in described ratio Mixing, is ground into powder, with the ethanol that determining alcohol is 95% as solvent, impregnates 60 hours, and employing is oozed Method of filtering, with the speed slowly percolation of 1ml per minute, collects percolate, and when being concentrated into 60 DEG C, relative density is The mastic of 1.26, is dried with spray dryer, is ground into 200 mesh subsequently, it is thus achieved that dry powder, is added The quality of ethanol is 4 times of second step mixture quality；

3rd step, is mixed remainder raw medicinal material in described ratio, adds pure and strong relative to mixture 5 times amount Degree is the alcohol reflux 3 times of 80%, each 2 hours, filters respectively, and each time filtrate merges, and returns Receiving ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.21, is dried in 60 DEG C of reduced vacuum, Dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 4 Times water dissolution, with 40% sodium hydroxide solution regulate pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 20%, ethyl hydroxybenzoate 0.05%.

Embodiment 2: oral solutions

Take Herba Senecionis Argunensis 280g, Herba Dracocephali Rupestris 130g, Herba Haloragidis Micranthae 210g, Flos Cleistocalycis Operculati 90g, Radix Glycosmidis Citrifoliae 170g, Radix Seu Caulis Rhaphidophorae Decursivae 220g, Radix Rumicis Patientiae 320g, Herba polygoni hydropiperis 110g, Herba Emiliae 200g, Prospiroboli joannsi 240g, Cortex Seu Folium Linderae 260g, Rubus Parvifolius L. 160g, Radix spiraeae prunifoliae 210g, Fructus Cucumidis sativi core grass 130g, goldenrain tree sweet-scented osmanthus 260g, rhizoma scirpi 220g, Grass dragon root 150g and Radix Phyllanthi 300g.

Its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, cattle Cc, Herba polygoni hydropiperis and Herba Emiliae mixing, adding relative to mixture 4 times amount determining alcohol is the alcohol reflux of 60% Extracting 2 times, each 2.5 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into 70 DEG C the closeest Degree is the mastic of 1.31, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times amount water, boils 2 hours, filtering, being concentrated into 70 DEG C of relative densities is the mastic of 1.28；

3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum are dried, Get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described The alcohol content of containing alcohol mastic is 70%；Described containing alcohol mastic is carried out successively chilling treatment, precipitation process, Filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, and wherein, the chilling treatment time is 35 hours, Refrigerated storage temperature is 4 DEG C；

5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated, Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is 1∶0.2；Described dealcoholysis mastic is 1: 0.002 with the weight ratio of described activated carbon；Described heat treated Time is 30 minutes, and temperature is 100 DEG C；

6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process, Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20-38g, carries out acute poison Property test.Mice is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours before experiment, incite somebody to action this The Chinese materia medica syrup of inventive embodiment 1 preparation is dissolved in water, (concentration is 8.73g crude drug/ml, High concentration) gavage, gavage volume is 5ml/kg (i.e. unit dosage form is 43.65 crude drugs/kg), Matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, connects after administration Continuous observe 14 days, and record mice toxic reaction and death toll.Test result indicate that: with matched group Relatively, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, Drinking-water, body weight increase the most normal.Syrup LD50 > 43.65 crude drugs/the kg of the Mouse oral gavage present invention, Every day, maximum dosage-feeding was 87.3 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 7.9g crude drug/ Day/people, adult's body weight is in terms of 60KG, and average dosage is 0.132g crude drug/kg/ day.By weighing machine: The dosis tolerata of the Chinese medicine of mice (average weight is in terms of 29g) the oral administration gavage present invention as quantity 661 Times.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: three groups of mices (often group 20) are pressed by Chinese medicine embodiment 1 syrup of the present invention 14.25,27.31 and 41.49g crude drugs/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 Secondary) and drug withdrawal 3 weeks after, result shows: Chinese medicine of the present invention is to the hair of mice, behavior, defecation, body The indexs such as weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, internal organs meat Eye does not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, and mice Each internal organs are all without substantially changing.Illustrate that Chinese medicine of the present invention is little, after drug withdrawal also to toxicity after mice long-term prescription There is no difference reaction, application safety.

Clinical data:

Case selection: all 120 example cases derive from this Out-patient Department and the cystic cyclomastopathy being in hospital Patient, is randomly divided into two groups by patient, treatment group and each 60 examples of matched group.Treatment group 60 example, the age 26～57 years old；The course of disease 3 months～6 years；Wherein, unilateral patient 18 example, bilateral patient 42 example；Not Wedding patient 9 example, married patients 51 example.Matched group 60 example, age 24～55 years old；The course of disease 3 months～ 5 years；Wherein, unilateral patient 17 example, bilateral patient 43 example；Unmarried patient 8 example, married patients 52 Example.Treatment group compares at aspects such as age, the course of disease, site of pathological change, marriage and childbirth and clinical symptoms with matched group No significant difference, has comparability.

Diagnostic criteria: 1, mostly be Women of Childbearing Age, but youth or elderly woman also show.2, multiple many The lump in breast of sample, including single tuberosity, multiple tuberosity and blockiness tuberosity sense.Breast examination is accessible Multiple nodules, capsule sample sense, body of gland thickens, and can diminish or deliquescing after menstruation, and tuberosity is not of uniform size, matter Tough, obscure boundary, mobility can.3, often there is periodically premenstrual distending pain of the breast, and capsule increases；The moon passes through After alleviate and capsule reduces.Medical history elder periodically can be inconspicuous.4, minority can be with nipple discharge, nipple Discharge is unilateral or bilateral, mostly is serosity or serosity is courageous and upright, and pure blood person is less.If discharge is slurry When liquid courage and uprightness or pure blood, then there are intracanalicular papilloma or people's comedocarcinoma possible.5, B ultrasonic, molybdenum target X Line is taken the photograph the inspections such as sheet, near infrared ray inspection, MRI and Needle-sucking cytology checks and is contributed to diagnosis.

Therapeutic Method:

Matched group: give Tamoxifen citrate tablet (Yangtze River Pharmaceutical) 10mg, is administered orally for 2 times every day；3 Within individual month, it is a course for the treatment of, treats two courses for the treatment of.

Treatment group: on the basis of matched group conventional western medicine is treated, of the present invention Chinese medicine embodiment 1 is simultaneously administered orally Syrup, each 20ml, three times a day；Within 3 months, it is a course for the treatment of, treats two courses for the treatment of.

Curative effect judging standard: clinical cure: lump in breast and pain disappear.Effective: lump in breast reduces More than 1/2, pain disappears or substantially disappears.Effective: lump in breast reduces, pain relief.Invalid: Lump in breast and pain are without improving.

Therapeutic outcome: after two groups are treated 6 months respectively, statistical result sees Tables 1 and 2.

Clinical efficacy comparison (unit: example) after treating 6 months respectively organized by 1 liang of table

As it can be seen from table 1 treatment group uses the Chinese medicine of the present invention, western medical treatment mammary gland capsule is coordinated to increase Raw disease, relative to matched group, on therapeutic effect, has and is markedly improved.

2 liang of table is organized clinical cure number and time after treating 6 months respectively and is compared (unit: example/%)

Group	Number of cases	Medication 3 months	Medication 4 months	Medication 5 months	Medication 6 months
						Treatment group	46	19 (31.7%)	29 (48.3%)	39 (65%)	46 (76.7%)
Matched group	25	9 (15%)	14 (23.3%)	22 (36.7%)	25 (41.6%)

From table 2 it can be seen that treatment group uses the Chinese medicine of the present invention, western medical treatment mammary gland capsule is coordinated to increase Raw disease, relative to matched group, not only better efficacy, takes effect the most faster.

Untoward reaction: matched group 60 example patient, in therapeutic process, there is Nausea and vomiting, appetite in 5 examples Depressed gastrointestinal reaction such as grade, there is Blushing in 3 examples, and leukopenia occurs in 1 example, all do not occur other Obvious adverse reaction.Treatment group 60 example patient, in therapeutic process, there is Nausea and vomiting in 3 examples, the most not Liver function injury or other obvious adverse reaction occur.

Relapse rate is added up: divide 46 examples for the treatment of group clinical cure and 25 examples of matched group clinical cure Not following up a case by regular visits to 6 months, result is added up, and treatment group is without recurrence, and relapse rate is 0%；Matched group recurs 3 people, Relapse rate 12%.

Concrete case: high certain, female, 49 years old, patient is the unconscious right breast of middle discovery when having a bath before about 4 months Adenoncus thing, about Fructus Litchi size, without pain, change without local skin redness heat, without nipple abnormal secretion thing, Do not give concern, after because distending pain of the breast and tenderness occur, see a doctor to the court, through B ultrasonic, magnetic resonance and cell Learning the clinical definites such as inspection is cystic cyclomastopathy.Give Tamoxifen citrate tablet and the present invention implements The syrup of example 1, treats 3 months, and lump in breast and pain disappear, and clinical cure follows up a case by regular visits to 6 months Without recurrence.

The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention, Still fall within the protection domain of technical solution of the present invention.

Claims (9)

1. the Chinese medicine treating cystic cyclomastopathy, it is characterised in that described Chinese medicine includes following former Material medical material: Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae, Rubus Parvifolius L., Radix spiraeae prunifoliae, Fructus Cucumidis sativi core grass, goldenrain tree sweet-scented osmanthus, rhizoma scirpi, Grass dragon root and Radix Phyllanthi.

2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of described raw medicinal material For: Herba Senecionis Argunensis 20～30 parts, Herba Dracocephali Rupestris 10～20 parts, Herba Haloragidis Micranthae 15～25 parts, Flos Cleistocalycis Operculati 5～ 15 parts, Radix Glycosmidis Citrifoliae 10～20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 20～30 parts, Radix Rumicis Patientiae 25～35 parts, Herba polygoni hydropiperis 8～18 Part, Herba Emiliae 10～20 parts, Prospiroboli joannsi 25～30 parts, Cortex Seu Folium Linderae 20～30 parts, Rubus Parvifolius L. 10～20 Part, Radix spiraeae prunifoliae 15～25 parts, Fructus Cucumidis sativi core grass 5～15 parts, goldenrain tree sweet-scented osmanthus 20～30 parts, rhizoma scirpi 15～25 Part, grass dragon root 10～20 parts and Radix Phyllanthi 25～35 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the weight portion of described raw medicinal material Number ratio is: Herba Senecionis Argunensis 25～30 parts, Herba Dracocephali Rupestris 12～17 parts, Herba Haloragidis Micranthae 17～22 parts, Flos Cleistocalycis Operculati 8～13 parts, Radix Glycosmidis Citrifoliae 13～18 parts, Radix Seu Caulis Rhaphidophorae Decursivae 22～27 parts, Radix Rumicis Patientiae 28～33 parts, Herba polygoni hydropiperis 10～ 15 parts, Herba Emiliae 15～20 parts, Prospiroboli joannsi 23～28 parts, Cortex Seu Folium Linderae 22～27 parts, Rubus Parvifolius L. 15～ 20 parts, Radix spiraeae prunifoliae 20～25 parts, Fructus Cucumidis sativi core grass 9～14 parts, goldenrain tree sweet-scented osmanthus 25～30 parts, rhizoma scirpi 18～ 23 parts, grass dragon root 15～20 parts and Radix Phyllanthi 25～30 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the weight portion of described raw medicinal material Number ratio is: Herba Senecionis Argunensis 28 parts, Herba Dracocephali Rupestris 13 parts, Herba Haloragidis Micranthae 21 parts, Flos Cleistocalycis Operculati 9 parts, Radix Glycosmidis Citrifoliae 17 parts, Radix Seu Caulis Rhaphidophorae Decursivae 22 parts, Radix Rumicis Patientiae 32 parts, Herba polygoni hydropiperis 11 parts, Herba Emiliae 20 parts, Prospiroboli joannsi 24 Part, Cortex Seu Folium Linderae 26 parts, Rubus Parvifolius L. 16 parts, Radix spiraeae prunifoliae 21 parts, Fructus Cucumidis sativi core grass 13 parts, goldenrain tree sweet-scented osmanthus 26 parts, Rhizoma scirpi 22 parts, grass dragon root 15 parts and Radix Phyllanthi 30 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterised in that the weight portion of described raw medicinal material Number ratios are: Herba Senecionis Argunensis 26 parts, Herba Dracocephali Rupestris 16 parts, Herba Haloragidis Micranthae 18 parts, Flos Cleistocalycis Operculati 12 parts, mountain are little Fructus Citri tangerinae 14 parts, Radix Seu Caulis Rhaphidophorae Decursivae 26 parts, Radix Rumicis Patientiae 30 parts, Herba polygoni hydropiperis 15 parts, Herba Emiliae 16 parts, Prospiroboli joannsi 27 parts, Cortex Seu Folium Linderae 22 parts, Rubus Parvifolius L. 20 parts, Radix spiraeae prunifoliae 24 parts, Fructus Cucumidis sativi core grass 10 parts, goldenrain tree sweet-scented osmanthus 28 Part, rhizoma scirpi 20 parts, grass dragon root 18 parts and Radix Phyllanthi 27 parts.

6. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is syrup Agent, its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae and Radix Seu Caulis Rhaphidophorae Decursivae by institute State ratio mixing, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heat back Stream extracts 2～4 times, each reflux, extract, 2 hours～3 hours, and united extraction liquid uses tube centrifuge Centrifugal remove impurity, is evaporated to when 60 DEG C relative under conditions of 60 DEG C～70 DEG C by the extracting solution after remove impurity Density is the medicinal liquid of 1.05～1.10, and the concentrated solution spray dryer after concentrating is dried, and pulverizes subsequently Become 100～200 mesh, it is thus achieved that dry powder；

Second step, by Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae and Rubus Parvifolius L. in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed remainder raw medicinal material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter respectively, Each time filtrate merges, and reclaims ethanol, and when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, It is dried in 55 DEG C～65 DEG C of reduced vacuum, obtains dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～ The water dissolution of 5 times, with 40% sodium hydroxide solution regulation pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 30～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3% or parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

7. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is oral Liquor, its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, cattle Cc, Herba polygoni hydropiperis and Herba Emiliae mixing, adding relative to 3 times of mixture～5 times amount determining alcohols is 55%～65% Alcohol reflux 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims second Alcohol, is concentrated into the mastic that 70 DEG C of relative densities are 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum Being dried, get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～ 40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；

5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated, Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is 1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process, Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.

8. the preparation method of the Chinese medicine described in a claim 1 to 5, it is characterised in that described Chinese medicine Dosage form be syrup, its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae and Radix Seu Caulis Rhaphidophorae Decursivae by institute State ratio mixing, add the ethanol that determining alcohol is 80%～90% relative to mixture 4～6 times, heat back Stream extracts 2～4 times, each reflux, extract, 2 hours～3 hours, and united extraction liquid uses tube centrifuge Centrifugal remove impurity, is evaporated to when 60 DEG C relative under conditions of 60 DEG C～70 DEG C by the extracting solution after remove impurity Density is the medicinal liquid of 1.05～1.10, and the concentrated solution spray dryer after concentrating is dried, and pulverizes subsequently Become 100～200 mesh, it is thus achieved that dry powder；

Second step, by Radix Rumicis Patientiae, Herba polygoni hydropiperis, Herba Emiliae, Prospiroboli joannsi, Cortex Seu Folium Linderae and Rubus Parvifolius L. in described ratio Mixing, be ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～ 72 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate To the mastic that relative density when 60 DEG C is 1.25～1.27, it is dried with spray dryer, is ground into subsequently 100～200 mesh, it is thus achieved that dry powder, the quality of the ethanol added is the 3～5 of second step mixture quality Times；

3rd step, is mixed remainder raw medicinal material in described ratio, adds relative to mixture 4～6 times amount alcohol Concentration be 70%～80% alcohol reflux 2～4 times, each 1 hour～3 hours, filter respectively, Each time filtrate merges, and reclaims ethanol, and when being concentrated into 60 DEG C, relative density is the mastic of 1.20～1.22, It is dried in 55 DEG C～65 DEG C of reduced vacuum, obtains dry powder；

4th step, the dry powder blend that the first step is obtained to the 3rd step, add relative to mixture quality 3～ The water dissolution of 5 times, with 40% sodium hydroxide solution regulation pH value to 7.0, be subsequently added correctives sucrose, Preservative mix homogeneously, obtains syrup, the correctives of addition, preservative and the content in medicine thereof: Sucrose 30～60%, Pyrusussuriensis acids preservative such as potassium sorbate 0.1～0.3% or parabens Preservative such as ethyl hydroxybenzoate 0.01～0.05%.

9. the preparation method of the Chinese medicine described in a claim 1 to 5, it is characterised in that described Chinese medicine Dosage form be oral solutions, its preparation method comprises the following steps:

The first step, by Herba Senecionis Argunensis, Herba Dracocephali Rupestris, Herba Haloragidis Micranthae, Flos Cleistocalycis Operculati, Radix Glycosmidis Citrifoliae, Radix Seu Caulis Rhaphidophorae Decursivae, cattle Cc, Herba polygoni hydropiperis and Herba Emiliae mixing, adding relative to 3 times of mixture～5 times amount determining alcohols is 55%～65% Alcohol reflux 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims second Alcohol, is concentrated into the mastic that 70 DEG C of relative densities are 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum Being dried, get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～ 40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；

5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated, Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is 1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process, Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.