CN107468920A - A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction - Google Patents

A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction Download PDF

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Publication number
CN107468920A
CN107468920A CN201710537793.4A CN201710537793A CN107468920A CN 107468920 A CN107468920 A CN 107468920A CN 201710537793 A CN201710537793 A CN 201710537793A CN 107468920 A CN107468920 A CN 107468920A
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parts
chinese medicine
fruit
chinese
tuber
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唐晓春
李艳
刘淑珍
刘振艳
赵学静
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract

A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction, the bulk drug of the Chinese medicine preparation are made up of Flos Ilicis Asprellae, the tuber of pinellia, Fructus Malvae Vertillatae, peach kernel, Asian puccoon, the seed of cowherb, rhizoma Gastrodiae, the fruit of Chinese magnoliavine, corn stigma, rush, golden cypress, the tuber of dwarf lilyturf, Chinese violet, akebi, pseudo-ginseng, great burdock achene, oriental wormwood, rhizoma alismatis, the root of kudzu vine, giant knotweed, Paris polyphylla, the fruit of glossy privet, Semen Cuscutae, Ramulus Taxilli, eclipta, luffa, sweet wormwood, aloe, benbie.

Description

A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction
Technical field
The invention belongs to pharmaceutical technology field, is related to a kind of Chinese medicine composition, and in particular to it is anti-that one kind treats blood transfusion haemolysis The Chinese medicine preparation answered.
Background technology
After blood transfusion hemolytic reaction refers in transfusion procedure or terminated, because input blood or its product or used in transfusion and infusion assemblies And caused adverse reaction.Symptom caused by blood transfusion hemolytic reaction mainly has:1st, allergic reaction.Allergic reaction includes:Nettle Rash, angioneurotic edema, arthralgia, uncomfortable in chest, shortness of breath, expiratory dyspnea, hypotensive shock.2nd, nonhemolytic febrific reaction.It is defeated Shiver with cold, heating occurs in a short time or in transfusion procedure after blood, up to 38 DEG C~41 DEG C, patient dislikes fever patient's body temperature The heart, vomiting, flush, reaction continue 1~2 hour, then perspire, bring down a fever.3rd, post-transfusion purpura.7 days left sides after transfusion Right morbidity, morbidity drastically, there is obvious chilly, high fever, nettle rash;When have headache, pectoralgia, expiratory dyspnea.There are different parts Bleeding, the extensive petechiae of skin and ecchymosis, gingiva bleeding gingival hemorrhage, nosebleed, melena.4th, graft versus host disease(GVH disease).Heating, skin tide Red, fash, severe diarrhea, hepatosplenomegaly etc..5th, transfusion hemochromatosis.Clinically occur cutaneous pigmentation, hepatic disorder, Diabetes, cardiac arrhythmia, cardiac insufficiency, hypogona dism.
The hemolytic reaction for the treatment of blood transfusion at present is mostly to answer acute, such as dexamethasone injection, adrenaline, although these The symptom that energy rapid recovery patient occurs, but as symptom, the Western medicine such as purpura, non-hemolytic heating, hemochromatosis are often brought Very big side effect, the body to patient bring certain injury.Publication No. CN106389821A Chinese patent discloses A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction, the Chinese medicine preparation are made up of the medicine of following parts by weight:Radix Astragali 25-35 Part, rhodiola root 10-20 parts, radix pseudostellariae 5-15 parts, radix glehniae 15-25 parts, rhizoma atractylodis macrocephalae 15-25 parts, Poria cocos 13-23 parts, juglandis,semen 13-23 parts, root of herbaceous peony 10-20 parts, Radix Angelicae Sinensis 13-23 parts, prepared rhizome of rehmannia 13-23 parts, Ligusticum wallichii 10-20 parts, red sage root 15-25 parts, safflower 4- 14 parts, teasel root 19-29 parts, stir-baked CORTEX EUCOMMIAE 13-23 parts, Ramulus Taxilli 13-23 parts, donkey-hide gelatin 3-9 parts, deer horn glue 3-9 parts, Semen Cuscutae 10- 20 parts, fruit of Chinese wolfberry 10-20 parts, the sub- 10-20 parts of mulberries, oxhide gelatin 10-20 parts, eclipta 13-23 parts, radix paeoniae rubrathe 10-20 parts, mountain Zhu Cornel 7-17 parts, psoralea corylifolia 10-20 parts, tuber of dwarf lilyturf 10-20 part, jujube 7-17 parts, honey-fried licorice root 3-9 parts.Clinical practice discovery, the Chinese medicine Preparation slowly effect, curative effect is poor, a certain degree of side effect be present.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction, the Chinese medicine preparation is with strong points, It is quick, good effect, without bad and toxic side effect.
The above-mentioned purpose of the present invention is realized by following technical proposals:
A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction, the bulk drug of the Chinese medicine preparation is by Flos Ilicis Asprellae, the tuber of pinellia, winter certain herbaceous plants with big flowers Fruit, peach kernel, Asian puccoon, the seed of cowherb, rhizoma Gastrodiae, the fruit of Chinese magnoliavine, corn stigma, rush, golden cypress, the tuber of dwarf lilyturf, Chinese violet, akebi, pseudo-ginseng, Great burdock achene, oriental wormwood, rhizoma alismatis, the root of kudzu vine, giant knotweed, Paris polyphylla, the fruit of glossy privet, Semen Cuscutae, Ramulus Taxilli, eclipta, luffa, sweet wormwood, aloe, Benbie forms.
Further, be made the Chinese medicine preparation raw material composition and parts by weight be:Flos Ilicis Asprellae 3-4 parts, tuber of pinellia 5-8 parts, Fructus Malvae Vertillatae 12-15 parts, peach kernel 10-16 parts, Asian puccoon 3-8 parts, seed of cowherb 5-12 parts, rhizoma Gastrodiae 12-17 parts, fruit of Chinese magnoliavine 4-6 parts are beautiful Rice palpus 8-12 parts, rush 3-4 parts, golden cypress 12-15 parts, tuber of dwarf lilyturf 5-9 part, Chinese violet 7-12 parts, akebi 4-9 parts, pseudo-ginseng 15- 20 parts, great burdock achene 10-15 parts, oriental wormwood 8-12 parts, rhizoma alismatis 2-5 parts, root of kudzu vine 3-7 parts, giant knotweed 11-14 parts, Paris polyphylla 9-15 parts, glossy privet Sub- 3-6 parts, Semen Cuscutae 8-13 parts, Ramulus Taxilli 3-5 parts, eclipta 1-3 parts, luffa 5-10 parts, sweet wormwood 5-10 parts, aloe 13- 16 parts, benbie 3-10 parts.
Further, be made the Chinese medicine preparation raw material composition and parts by weight be:3 parts of Flos Ilicis Asprellae, 5 parts of the tuber of pinellia, winter certain herbaceous plants with big flowers 12 parts of fruit, 16 parts of peach kernel, 3 parts of Asian puccoon, 12 parts of the seed of cowherb, 12 parts of rhizoma Gastrodiae, 6 parts of the fruit of Chinese magnoliavine, 8 parts of corn stigma, 3 parts of rush, 15 parts of golden cypress, 5 parts of the tuber of dwarf lilyturf, 10 parts of Chinese violet, 9 parts of akebi, 15 parts of pseudo-ginseng, 15 parts of great burdock achene, 8 parts of oriental wormwood, 5 parts of rhizoma alismatis, Pueraria lobota 3 parts of root, 14 parts of giant knotweed, 9 parts of Paris polyphylla, 6 parts of the fruit of glossy privet, 8 parts of Semen Cuscutae, 5 parts of Ramulus Taxilli, 1 part of eclipta, 10 parts of luffa are blue or green 5 parts of wormwood artemisia, 16 parts of aloe, 10 parts of benbie.
Further, be made the Chinese medicine preparation raw material composition and parts by weight be:4 parts of Flos Ilicis Asprellae, 8 parts of the tuber of pinellia, winter certain herbaceous plants with big flowers 15 parts of fruit, 10 parts of peach kernel, 8 parts of Asian puccoon, 5 parts of the seed of cowherb, 17 parts of rhizoma Gastrodiae, 4 parts of the fruit of Chinese magnoliavine, 10 parts of corn stigma, 4 parts of rush, 13 parts of golden cypress, 6 parts of the tuber of dwarf lilyturf, 12 parts of Chinese violet, 4 parts of akebi, 20 parts of pseudo-ginseng, 10 parts of great burdock achene, 12 parts of oriental wormwood, 2 parts of rhizoma alismatis, Pueraria lobota 7 parts of root, 11 parts of giant knotweed, 15 parts of Paris polyphylla, 3 parts of the fruit of glossy privet, 13 parts of Semen Cuscutae, 3 parts of Ramulus Taxilli, 3 parts of eclipta, 5 parts of luffa are blue or green 10 parts of wormwood artemisia, 13 parts of aloe, 3 parts of benbie.
Further, be made the Chinese medicine preparation raw material composition and parts by weight be:4 parts of Flos Ilicis Asprellae, 7 parts of the tuber of pinellia, winter certain herbaceous plants with big flowers 13 parts of fruit, 11 parts of peach kernel, 4 parts of Asian puccoon, 6 parts of the seed of cowherb, 13 parts of rhizoma Gastrodiae, 5 parts of the fruit of Chinese magnoliavine, 12 parts of corn stigma, 3 parts of rush, 12 parts of golden cypress, 9 parts of the tuber of dwarf lilyturf, 7 parts of Chinese violet, 5 parts of akebi, 18 parts of pseudo-ginseng, 11 parts of great burdock achene, 9 parts of oriental wormwood, 4 parts of rhizoma alismatis, the root of kudzu vine 6 parts, 12 parts of giant knotweed, 13 parts of Paris polyphylla, 4 parts of the fruit of glossy privet, 9 parts of Semen Cuscutae, 4 parts of Ramulus Taxilli, 2 parts of eclipta, 6 parts of luffa, sweet wormwood 6 Part, 14 parts of aloe, 5 parts of benbie.
Further, the Chinese medicine preparation is prepared in following manner:
(1) each medicinal material of components by weight percent described in the Chinese medicine preparation is taken, is put into marmite and fries 30 minutes~40 minutes, is used Pulverizer is ground into smalls, is screened into the mesh powder of 100 mesh~200;
(2) it is 85%~90% to add obtained powder in step (1) relative to the determining alcohol of 6~8 times of mixture of powders Ethanol, be heated to boiling reflux 3~5 hours, filter, use percolation to be received with 1~2ml per minute speed slowly diacolation Collect percolate, relative density is 1.04~1.10 when 60~70 DEG C are then concentrated under reduced pressure under 0.06~0.09Mpa of vacuum Lotion, spray drying, 80~85 DEG C of 160~175 DEG C of EAT, the leaving air temp of spray dryer, be then ground into powder End, dried cream powder is made;
(3) dried cream powder made from step (2) is added into appropriate auxiliary material and granule, capsule, tablet is made.
The Chinese medicine preparation for the treatment of blood transfusion hemolytic reaction provided by the present invention, it is using common Chinese herbal medicine as raw material, fully Play the property of medicine of each component:
Flos Ilicis Asprellae, it is bitter, sweet, it is cool.Major function:It is clearing heat and detoxicating, promote the production of body fluid to quench thirst.For catching a cold, hyperpyrexia polydipsia, tonsillitis, Sphagitis, tracheitis, pertussis, enteritis, dysentery, catarrhal jaundice, wild gill fungus, arsenic intoxication.For herbal tea primary raw material;Leaf external application Control traumatic injury, carbuncle furuncle poison.
The tuber of pinellia:It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, coma due to blocking of the respiratory system head Bitterly, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus;Controlling outward carbuncle swells subcutaneous nodule is used in life.
Fructus Malvae Vertillatae:Alias chingma abutilon seed.Source:This strain Mongols conventional crude drugs, it is malvaceae plant winter certain herbaceous plants with big flowers Malva Verticillata L. dry mature fruit.Harvested when summer, two season of autumn fruit maturation, remove impurity, dry in the shade.Nature and flavor:Sweet, It is puckery, it is cool.Major function:Reducing fever and causing diuresis, detumescence.It is thirsty for renal shutdown, oedema;Urinary tract infections.
Peach kernel:Promoting blood circulation, relax bowel, it is relieving cough and asthma.For Amenorrhea, dysmenorrhoea , wei lump in the abdomen lump in the abdomens, injury from falling down, intestinal dryness Constipation dissolving stasis blood acts on antiinflammatory action anti-allergic effects.
Asian puccoon:It is cold in nature, it is sweet, salty.The thoughts of returning home, Liver Channel.Its major function:Cool blood, promoting blood circulation, promoting eruption of detoxifying.
The seed of cowherb:It is bitter, mild-natured, return stomach, there is the effect of newborn under invigorate blood circulation, be good at it is promoting blood circulation, row without Walk, walk without keeping, upper energy promoting lactation is lower to lead to amenorrhoea.
Rhizoma Gastrodiae:Property, put down.Taste, it is sweet.Master enters Liver Channel.This product Inflammation Zhijing, suppressing liver-YANG, dispelling wind and removing obstruction in the meridians.To control dizziness, head The key medicine of pain;Again in extremity numbness, hands and feet caused by paralysis, arthralgia pain due to rheumatism, the good merchantable brand of muscles and bones contraction.
The fruit of Chinese magnoliavine is warm-natured;It is sour, sweet, return lung, the heart, kidney channel.Major function:Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming. For injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.Modern study, it is yellow containing abundant organic acid, vitamin, class Ketone, phytosterol and the lignan for having potent reactivation, it is also to have essence, gas, one of a small number of medicinal materials of refreshing three big helps concurrently.
Corn stigma:Diuresis, expel the heat-evil, soothing the liver, cholagogic.Control nephritic dropsy, tinea pedis, icterohepatitis, hypertension, cholecystitis, courage Calculus, diabetes, hematemesis and epistaxis, nasosinusitis, acute mastitis.The present invention selects grass maize ZeamaysL. style and post Head.
Rush:Base:For the stem marrow or herb of rush family plant rush.Chemical analysis:Stem marrow fibre-bearing, fat Oil, protein etc..Stem contains polysaccharide.Nature and flavor:It is sweet light, tremble with fear.Channel tropism:Enter the heart, lung, small intestinl channel.Major function:Clearing heart fire, profit Urinate treating stranguria.Control gonorrhoea, oedema, difficult urination, jaundice with damp-heat pathogen, dysphoria and insomnia, nocturnal fretfulness in infants, larynx numbness, wound.
Golden cypress:This product is rutaceae wampee Phellodendron chinense Schneid. dry bark. Bitter, cold in nature, energy heat-clearing and damp-drying drug, except lower Jiao is wet swollen.《Medication heart method》Record golden cypress:" control the unbearably painful person of sore." golden cypress contains A large amount of composition of alkaloids, there is the antibacterial action of wide spectrum, can block nerves section, Central nervous plays the role of suppression.
It is the tuber of dwarf lilyturf, sweet, slight bitter, it is slightly cold.The thoughts of returning home, lung, stomach.Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.Consumptive disease cough Cough, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines;Pharyngeal diphtheria.
Chinese violet meridian distribution of property and flavor:Bitter, acrid, cold, it is nontoxic;The thoughts of returning home, Liver Channel.Function is with curing mainly:Clearing heat and detoxicating, cool blood disappears It is swollen.Cure mainly jaundice, dysentery.
Akebi bitter, cold nature, returns spleen, the heart, small intestine, kidney, bladder warp, have heat-clearing, diuresis, invigorate blood circulation, promote blood circulation, let out it is turbid, Toxin expelling and other effects, control the illness such as red red urine, stranguria with turbid discharge, oedema, irritable feverish sensation in chest, arthralgia pain due to rheumatism, alactation, amenorrhoea, dysmenorrhoea.
Pseudo-ginseng:Pseudo-ginseng property sugariness slight bitter, warm-natured, Return liver, stomach are used as medicine with root, root-like stock.It is rare traditional Chinese medicine, raw use can Hemostasia and dissipation blood stasis, swelling and pain relieving, there is good hemostasia effect, significant hematopoiesis function;It can tighten and improve Coronary microcirculation, three Seven are used as medicine with a long history, act on the peculiar treasured being considered as by ancient Chinese medicine doctor in medicine, therefore have the saying of " invaluable ".Pseudo-ginseng " taste micro-sweet And bitter, the taste quite like ginseng." " all canes flutter hurt, the dripping person of hemostasis, chew stopping for rotten net for catching birds or fish immediately, bruise person is dissipated.If by During cane, one, two money are first taken, then the blood not centre of punch, it is preferably taken especially after cane, postpartum clothes are also good.On the whole this medicine temperature, sweet and slightly bitter taste, and Bright, cloudy blood system of fainting the medicine of sun, therefore all blood disease can be controlled ".《Book on Chinese herbal medicine is looked for the truth》Record:" pseudo-ginseng, common people only know function hemostasis and pain-relieving. Hardly realize that pain aches works because of blood stasis, blood is because applying scattered and blood stops.The bitter temperature of pseudo-ginseng smell, can be in its blood stasis of blood systemization." pseudo-ginseng can increase Coronary blood flow, reducing heart rate, myocardial oxygen consumption is reduced, increase myocardium oxygen-resistant ability, improve microcirculation, release smooth muscle spasm Effect.
Great burdock achene:The effect of with dispelling wind and heat from the body, facilitaing lung promoting eruption, relieving sore-throat dissipating bind, removing toxicity for detumescence, cure mainly cough due to wind-heat evil, pharynx Larynx swells and ache, macula is impermeable, rubella itch, sore swollen toxin.Drying and ripening selected from feverfew burdock Arctium lappa L. Fruit.
Oriental wormwood:Bitter, pungent, cold nature.Returns spleen, stomach, liver, gallbladder channel.Major function:Clearing away damp-heat, removing jaundice subcutaneous ulcer.Urinated for jaundice It is few, wet sore itch;Infectious jaundice type hepatitis.《This warp》:Main rheumatism fever and chills perverse trend, thermojunction jaundice.《Do not record》:The whole body is controlled to send out Huang, difficult urination, except head heat, go to lie prostrate lump in the abdomen.《Bencao Shiyi》:Get round by bribery, go stagnant heat, typhoid fever uses it.《Medical center bun will》:Hard kidney, Dry spleen is wet, go it is strongly fragrant, it is antipyretic.《Book on Chinese herbal medicine is new again》:Purging intense heat, soothing the liver, resolving sputum, cough-relieving sweating, dampness removing, detumescence, treat all poison of sore fire.
Rhizoma alismatis is the stem tuber of Notes On Alism At Aceae rhizoma alismatis.Theory of traditional Chinese medical science thinks that its is cold in nature, has the effect of clearing damp and promoting diuresis.It is modern Medical research, rhizoma alismatis can reduce serum total cholesterol and triacylglycerol content, slow down atherogenesis;Rhizoma alismatis and its system The agent modern times are additionally operable to treat auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc..But rhizoma alismatis has hepatotoxicity wind agitation, kidney Toxicity, it is improper to take, and liver, kidney can be allowed swelling and other poisoning symptoms occur.
The root of kudzu vine, it is sweet, pungent, it is cool in nature.Enter spleen, stomach.With rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, relieving restlessness stops the effect of warm.For Typhoid fever, warm headache Xiang Qiang, dysphoria with smothery sensation are quenched one's thirst, and diarrhea, dysentery, ecchymosis is impermeable, hypertension, angina pectoris, deaf.Clinically it is used for controlling High blood pressure neck pain, coronary disease and angina pectoris are treated, but also there is hypoglycemic effect.
Giant knotweed slight bitter, is slightly cold.Return liver, courage, lung channel.Function is clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain, only Cough resolving sputum.For joint pain, jaundice with damp-heat pathogen, Amenorrhea , wei lumps in the abdomen, coughing with a lot of sputum, scald, injury from falling down, carbuncle sore tumefacting virus. 《Medical center bun will》Carry it:Hard kidney, strong Yang yi Jing, strengthens the bone, and increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.
Paris polyphylla:Cold nature, bitter;It is slightly poisonous.Enter Liver Channel.It is clearing heat and detoxicating, swelling and pain relieving, cool liver arresting convulsion.Make in malignant boil to swell carbuncle Swollen, abscess of throat, venomous snake bite, the pain of injury caused by falling and tumbling, convulsion.《Compendium of Materia Medica》Carry:" poison of snakeworm, obtain that this controls stops, therefore There is flea to stop, sting not all names.Chong Tai, three layers, because its is lobate.”
The fruit of glossy privet, sweet, bitter, cold.Return liver and kidney channel.Filling liver kidney, strong waist and knee.Yin asthenia generating intrinsic heat is controlled, dizzy, mesh flower, tinnitus, waist Knees soreness, poliosis.It is nourishing liver and kidney, improving eyesight black hair.For dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, mesh are secretly failed to understand.《This Grass is just》:" yin-nourishing gas, Pingyin fire, solves dysphoria with smothery sensation hectic fever due to yin, and only abnormal sweating, quenches one's thirst, and stranguria with turbid discharge, uterine bleeding, has blood in stool, hematuria, the erosion of vulva, anal fistula pain Bitterly.Also clearing away the liver-fire, tear can be stopped with improving eyesight.”
Semen Cuscutae, it is convolvulaceous plant Cuscuta australis CuscutaaustralisR.Br. or Semen Cuscutae CuscutachinensisLam. dry mature seed.It is pungent, sweet, put down.Return liver, kidney, the spleen channel.It can tonify the liver and kidney, astringent sperm contracting urine, It is antiabortive, improving eyesight, antidiarrheal;External application disappears wind nti-freckle.For kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, enuresis frequent micturition.Vaginal bleeding due to deficiency of the kidney during pregnancy, Fetal irritability, blurred vision tinnitus, spleen kidney deficiency are rushed down;Externally treating leucoderma.
Ramulus Taxilli:For Loranthaceae evergreen dwarf shrub plant Ramulus Taxilli Loranthusparasiticus (L.) Merr. or Mistletoe Viscumcoloratum (Komar.) Nakai stem and branch with leaf.Nature and flavor bitter, sweet, flat.Return liver and kidney channel.Effect:Wind-dispelling It is wet, liver and kidney benefiting, strengthening the bones and muscles.《Japan hanako materia medica》:Help muscles and bones, beneficial blood vessels.
Eclipta:It is sweet, sour, it is cold in nature.Return kidney, Liver Channel.It is nourishing liver and kidney, cooling blood and hemostasis.It is early for tooth mobility, beard and hair In vain, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, traumatism and bleeding.
Luffa:Source:Medicine elementary source:For cucurbitaceous plant sponge gourd or the vascular bundle of sponge gourd ripening fruits difficult to understand.Nature and flavor:Taste It is bitter;It is cool in nature.Channel tropism:Return lung;Liver;Stomach.Major function:It is clearing and activating the channels and collaterals;Removing toxicity for detumescence.Main pain in chest and hypochondrium;Arthralgia pain due to rheumatism, passages through which vital energy circulates Contraction, alactation, the cough of lung gesture, carbuncle future sore, his carbuncle.
Sweet wormwood, bitter, acrid, cold.Return liver, gallbladder channel.Major function:Clearing away summerheat, except steaming, preventing malaria.Generated heat for summer-heat evil, the deficiency of Yin Heating, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills, jaundice with damp-heat pathogen.
Aloe:Bitter is cold in nature, removing heat from the liver, defaecation, desinsection;Additionally be used for have a headache, constipation, pediatric epilepsy scared, infantile malnutrition due to digestive disturbances or intestinalparasites ulcer Furuncle, burn and scald, tinea sore, hemorrhoid, atrophic rhinitis, scrofula, hepatitis, Biliary Calculi, wet tinea etc..Contain in the blade of aloe and have more than two Hundred kinds of compounds, it is central to include 20 kinds of mineral matters, 18 kinds of amino acid, 12 kinds of vitamins and other a variety of nutrients, bag Include a variety of glutinous polysaccharide, aliphatic acid, Anthraquinones and flavone compounds, sugar, organized enzyme etc..Anthraquinones also known as An Tela return agriculture to integrate Body, there is the effect of disinfection, be primarily present in juice.
Benbie:Acrid flavour, hardship, it is mild-natured.Clearing heat and promoting diuresis, promoting blood circulation by removing wind, subdhing swelling and detoxicating.For hypertension, facioplegia, Hemiplegia, injuries from falls as well is controlled, fractured.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Carry:" muscles and bones convulsive seizure due to phlegm-fire pain is controlled, it is numb in every limb meciless.Dispel whole body migration Wind, dissipate scrofula brothers' subcutaneous nodule.Control traumatic injury, synthetism.Only brain leakage nasosinusitis.Bag convulsive seizure due to phlegm-fire congestion and swelling pain.”
In the Chinese medicine composition of the present invention, pseudo-ginseng hemostatic stagnation resolvation, swelling and pain relieving, root of kudzu vine rising Yang expelling pathogenic factors from muscles and skin, relieving restlessness stop temperature, glossy privet Sub- filling liver kidney, strong waist and knee, the tuber of pinellia is eliminating dampness and eliminating phlegm, dissolving lump and resolving mass, rhizoma Gastrodiae suppressing liver-YANG, dispelling wind and removing obstruction in the meridians, and luffa is clearing and activating the channels and collaterals, solution Poison detumescence, is monarch drug in a prescription, fundamentally improves patient's constitution, relief of symptoms, strengthens patient's resistance.Asian puccoon cooling and activating blood, removing toxic substances Promoting eruption, golden cypress heat-clearing and damp-drying drug, except lower Jiao it is wet swollen, Chinese violet is clearing heat and detoxicating, cool blood detumescence, and Flos Ilicis Asprellae is clearing heat and detoxicating, promotes the production of body fluid to quench thirst, Fructus Malvae Vertillatae reducing fever and causing diuresis, detumescence, peach kernel promoting blood circulation, seed of cowherb invigorate blood circulation, giant knotweed is clearing heat and detoxicating, expelling wind and removing dampness, the scattered stasis of blood Analgesic therapy, Paris polyphylla is clearing heat and detoxicating, swelling and pain relieving, is ministerial drug above, while strengthening monarch drug in a prescription drug effect, removing toxicity for detumescence, promoting blood circulation, has The effect treatment symptom such as purpura, heating, nosebleed, bleeding gums.Fruit of Chinese magnoliavine nourishing generate fluid, kidney calming, tuber of dwarf lilyturf nourishing Yin and promoting production of body fluid, profit Lung clears away heart-fire, and eclipta is nourishing liver and kidney, cooling blood and hemostasis, corn stigma soothing the liver cholagogic, rush clearing heart fire, inducing diuresis for treating strangurtia, and akebi is clear Hot diuresis, blood circulation and channel invigorating, great burdock achene dispelling wind and heat from the body, removing toxicity for detumescence, oriental wormwood clearing away damp-heat, rhizoma alismatis clearing damp and promoting diuresis, Semen Cuscutae help liver Kidney, Ramulus Taxilli liver and kidney benefiting, strengthening the bones and muscles, sweet wormwood clearing away summerheat, except steam, preventing malaria, aloe removing heat from the liver, benbie clearing heat and promoting diuresis, promoting blood circulation Wind-dispelling, all medicines of the above make for assistant, the drug effect of auxiliary monarch drug in a prescription and ministerial drug, nourishing Yin and promoting production of body fluid, soothing the liver cholagogic, blood circulation and channel invigorating, clearing damp and promoting diuresis, Patient's constitution is effectively improved, reinvigoration is quick to treatment blood transfusion hemolytic reaction good effect.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with embodiment to this hair Bright technical scheme is clearly and completely described.Obviously, described embodiment is the part of the present invention, rather than entirely The embodiment in portion.Based on described embodiments of the invention, those of ordinary skill in the art are before without creative work The every other embodiment obtained is put, belongs to the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction of the present invention, takes following traditional Chinese medicine raw medicine:3 parts of Flos Ilicis Asprellae, the tuber of pinellia 5 Part, 12 parts of Fructus Malvae Vertillatae, 16 parts of peach kernel, 3 parts of Asian puccoon, 12 parts of the seed of cowherb, 12 parts of rhizoma Gastrodiae, 6 parts of the fruit of Chinese magnoliavine, 8 parts of corn stigma, lampwick 3 parts of grass, 15 parts of golden cypress, 5 parts of the tuber of dwarf lilyturf, 10 parts of Chinese violet, 9 parts of akebi, 15 parts of pseudo-ginseng, 15 parts of great burdock achene, 8 parts of oriental wormwood, rhizoma alismatis 5 Part, 3 parts of the root of kudzu vine, 14 parts of giant knotweed, 9 parts of Paris polyphylla, 6 parts of the fruit of glossy privet, 8 parts of Semen Cuscutae, 5 parts of Ramulus Taxilli, 1 part of eclipta, luffa 10 Part, 5 parts of sweet wormwood, 16 parts of aloe, 10 parts of benbie.
Wherein, the preparation method of the Chinese medicine preparation is:
(1) each medicinal material of components by weight percent described in the Chinese medicine preparation is taken, is put into marmite and fries 30 minutes~40 minutes, is used Pulverizer is ground into smalls, is screened into the mesh powder of 100 mesh~200;
(2) it is 85%~90% to add obtained powder in step (1) relative to the determining alcohol of 6~8 times of mixture of powders Ethanol, be heated to boiling reflux 3~5 hours, filter, use percolation to be received with 1~2ml per minute speed slowly diacolation Collect percolate, relative density is 1.04~1.10 when 60~70 DEG C are then concentrated under reduced pressure under 0.06~0.09Mpa of vacuum Lotion, spray drying, 80~85 DEG C of 160~175 DEG C of EAT, the leaving air temp of spray dryer, be then ground into powder End, dried cream powder is made;
(3) dried cream powder made from step (2) is added into appropriate auxiliary material and granule, capsule, tablet is made.
Embodiment 2:
A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction of the present invention, takes following traditional Chinese medicine raw medicine:4 parts of Flos Ilicis Asprellae, the tuber of pinellia 8 Part, 15 parts of Fructus Malvae Vertillatae, 10 parts of peach kernel, 8 parts of Asian puccoon, 5 parts of the seed of cowherb, 17 parts of rhizoma Gastrodiae, 4 parts of the fruit of Chinese magnoliavine, 10 parts of corn stigma, lampwick 4 parts of grass, 13 parts of golden cypress, 6 parts of the tuber of dwarf lilyturf, 12 parts of Chinese violet, 4 parts of akebi, 20 parts of pseudo-ginseng, 10 parts of great burdock achene, 12 parts of oriental wormwood, rhizoma alismatis 2 parts, 7 parts of the root of kudzu vine, 11 parts of giant knotweed, 15 parts of Paris polyphylla, 3 parts of the fruit of glossy privet, 13 parts of Semen Cuscutae, 3 parts of Ramulus Taxilli, 3 parts of eclipta, luffa 5 parts, 10 parts of sweet wormwood, 13 parts of aloe, 3 parts of benbie.
Preparation method is the same as embodiment 1.
Embodiment 3:
A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction of the present invention, takes following traditional Chinese medicine raw medicine:4 parts of Flos Ilicis Asprellae, the tuber of pinellia 7 Part, 13 parts of Fructus Malvae Vertillatae, 11 parts of peach kernel, 4 parts of Asian puccoon, 6 parts of the seed of cowherb, 13 parts of rhizoma Gastrodiae, 5 parts of the fruit of Chinese magnoliavine, 12 parts of corn stigma, lampwick 3 parts of grass, 12 parts of golden cypress, 9 parts of the tuber of dwarf lilyturf, 7 parts of Chinese violet, 5 parts of akebi, 18 parts of pseudo-ginseng, 11 parts of great burdock achene, 9 parts of oriental wormwood, rhizoma alismatis 4 Part, 6 parts of the root of kudzu vine, 12 parts of giant knotweed, 13 parts of Paris polyphylla, 4 parts of the fruit of glossy privet, 9 parts of Semen Cuscutae, 4 parts of Ramulus Taxilli, 2 parts of eclipta, luffa 6 Part, 6 parts of sweet wormwood, 14 parts of aloe, 5 parts of benbie.
Preparation method is the same as embodiment 1.
Acute toxicity test:
Using NIH mouse 40, SPF levels, male and female half and half, 20~22g of body weight, acute toxicity test is carried out.Mouse is random It is divided into two groups, every group 20, i.e. control group and administration group, fasting 12 hours before experiment;Piece prepared by embodiments of the invention 1 Agent 50g, solution, gavage being modulated into 150ml warm waters, gavage volume is 5ml/kg, and control group gives normal saline, one It is administered once, delivery time 6 hours, Continuous Observation 14 days after administration, and records toxic reaction and the death of mouse Number.Test result indicates that:Compared with control group, mouse has no notable difference, experiment Continuous Observation 14 days, mouse systemic after administration Situation, diet, drinking-water, body weight increase are normal.The Acute toxicity of the present invention is low, clinical application safety.
Six months long term toxicity tests:The tablet of the embodiment of the present invention 1 is continuously used by 10,20 and 30g crude drugs/kg mouse Medicine 16 weeks (1.0ml/100g body weight, 2 times a day) and be discontinued 4 weeks after, the results showed that:Chinese medicine of the present invention to the hair of mouse, OK Had no significant effect for indexs such as, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not have It is found difference change and histological indications shows, medication 16 weeks and after being discontinued 4 weeks, Organs of Mice nothing substantially changes Become.Illustrate that medicine of the present invention to small toxicity after mouse long-term prescription, does not have abnormal reaction, using safety yet after drug withdrawal.
Clinical reasoning:
In order to verify the effect of Chinese medicine composition of the present invention, in May, -2016 in March, 2015, randomly select in hospital at outpatient service Transfuse blood hemolytic reaction patient 277, wherein male 138, women 139, age 17-66 year, average age 43 ± 1.5 years old. 277 cases are randomly divided into two groups, wherein treatment group 140, control group 137, treatment group and control group patient are counting There was no significant difference in meaning has comparativity.
Treatment method:
The tablet of the embodiment of the present invention 1 is taken by treatment group, takes in the morning and evening at twice, and 3 tablets once, and 3 days are 1 course for the treatment of.
Control group oral dexamethasone, each 2.5mg, daily 2 twice, morning and evening one after each meal, and 3 days are 1 course for the treatment of.
The 1-2 course for the treatment of is treated altogether.
Efficacy assessment standard:
Cure:Blood transfusion hemolytic reaction and related symptoms whole disappear, and do not influence activity and work, do not occur any rear something lost Disease.
Take a turn for the better:Blood transfusion hemolytic reaction and associated clinical symptoms disappear substantially, and symptom substantially mitigates after treatment, does not influence day Normal live and work.
It is not cured:Blood transfusion hemolytic reaction clinical symptoms do not have any improvement or even aggravated.
Result of the test
Result of the test statistical analysis is as shown in table 1:
1 two groups of patient's effective percentage comparative analyses of table
Wherein, total effective rate=cure rate+obvious effective rate.
Conclusion (of pressure testing)
Compared with control group, the average cure rate for the treatment of group is 100%, and control group 72.3%, test group compares control group It is high 37.7 percentage points, illustrate that Chinese medicine preparation of the present invention has very significant technical advantage, Er Qieben compared with existing medicine The Chinese medicine preparation of invention at most only needs two courses for the treatment of (6 days) and existing to reach effective treatment to blood transfusion hemolytic reaction Technology Chinese medicine preparation needs more than 10 days, it is seen that Chinese medicine preparation of the invention achieves excellent therapeutic effect, is pushed away suitable for clinic Wide application.
Finally it should be noted that:The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations;Although The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that:It still may be used To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic; And these modifications or replacement, the essence of appropriate technical solution is departed from the scope of various embodiments of the present invention technical scheme.

Claims (6)

  1. A kind of 1. Chinese medicine preparation for treating blood transfusion hemolytic reaction, it is characterised in that:The bulk drug of the Chinese medicine preparation is by Flos Ilicis Asprellae, half Summer, Fructus Malvae Vertillatae, peach kernel, Asian puccoon, the seed of cowherb, rhizoma Gastrodiae, the fruit of Chinese magnoliavine, corn stigma, rush, golden cypress, the tuber of dwarf lilyturf, Chinese violet, wood Logical, pseudo-ginseng, great burdock achene, oriental wormwood, rhizoma alismatis, the root of kudzu vine, giant knotweed, Paris polyphylla, the fruit of glossy privet, Semen Cuscutae, Ramulus Taxilli, eclipta, luffa, green grass or young crops Wormwood artemisia, aloe, benbie composition.
  2. 2. the Chinese medicine preparation for the treatment of blood transfusion hemolytic reaction according to claim 1, it is characterised in that:The Chinese medicine system is made The raw material of agent forms and parts by weight are:Flos Ilicis Asprellae 3-4 parts, tuber of pinellia 5-8 parts, Fructus Malvae Vertillatae 12-15 parts, peach kernel 10-16 parts, Asian puccoon 3- 8 parts, seed of cowherb 5-12 parts, rhizoma Gastrodiae 12-17 parts, fruit of Chinese magnoliavine 4-6 parts, corn stigma 8-12 parts, rush 3-4 parts, golden cypress 12-15 Part, tuber of dwarf lilyturf 5-9 part, Chinese violet 7-12 parts, akebi 4-9 parts, pseudo-ginseng 15-20 parts, great burdock achene 10-15 parts, oriental wormwood 8-12 parts, pool Rush down 2-5 parts, root of kudzu vine 3-7 parts, giant knotweed 11-14 parts, Paris polyphylla 9-15 parts, fruit of glossy privet 3-6 parts, Semen Cuscutae 8-13 parts, Ramulus Taxilli 3-5 Part, eclipta 1-3 parts, luffa 5-10 parts, sweet wormwood 5-10 parts, aloe 13-16 parts, benbie 3-10 parts.
  3. 3. the Chinese medicine preparation for the treatment of blood transfusion hemolytic reaction according to claim 1, it is characterised in that:The Chinese medicine system is made The raw material of agent forms and parts by weight are:3 parts of Flos Ilicis Asprellae, 5 parts of the tuber of pinellia, 12 parts of Fructus Malvae Vertillatae, 16 parts of peach kernel, 3 parts of Asian puccoon, the seed of cowherb 12 parts, 12 parts of rhizoma Gastrodiae, 6 parts of the fruit of Chinese magnoliavine, 8 parts of corn stigma, 3 parts of rush, 15 parts of golden cypress, 5 parts of the tuber of dwarf lilyturf, 10 parts of Chinese violet, wood It is logical 9 parts, 15 parts of pseudo-ginseng, 15 parts of great burdock achene, 8 parts of oriental wormwood, 5 parts of rhizoma alismatis, 3 parts of the root of kudzu vine, 14 parts of giant knotweed, 9 parts of Paris polyphylla, 6 parts of the fruit of glossy privet, 8 parts of Semen Cuscutae, 5 parts of Ramulus Taxilli, 1 part of eclipta, 10 parts of luffa, 5 parts of sweet wormwood, 16 parts of aloe, 10 parts of benbie.
  4. 4. the Chinese medicine preparation for the treatment of blood transfusion hemolytic reaction according to claim 1, it is characterised in that:The Chinese medicine system is made The raw material of agent forms and parts by weight are:4 parts of Flos Ilicis Asprellae, 8 parts of the tuber of pinellia, 15 parts of Fructus Malvae Vertillatae, 10 parts of peach kernel, 8 parts of Asian puccoon, the seed of cowherb 5 parts, 17 parts of rhizoma Gastrodiae, 4 parts of the fruit of Chinese magnoliavine, 10 parts of corn stigma, 4 parts of rush, 13 parts of golden cypress, 6 parts of the tuber of dwarf lilyturf, 12 parts of Chinese violet, wood It is logical 4 parts, 20 parts of pseudo-ginseng, 10 parts of great burdock achene, 12 parts of oriental wormwood, 2 parts of rhizoma alismatis, 7 parts of the root of kudzu vine, 11 parts of giant knotweed, 15 parts of Paris polyphylla, the fruit of glossy privet 3 Part, 13 parts of Semen Cuscutae, 3 parts of Ramulus Taxilli, 3 parts of eclipta, 5 parts of luffa, 10 parts of sweet wormwood, 13 parts of aloe, 3 parts of benbie.
  5. 5. the Chinese medicine preparation for the treatment of blood transfusion hemolytic reaction according to claim 1, it is characterised in that:The Chinese medicine system is made The raw material of agent forms and parts by weight are:4 parts of Flos Ilicis Asprellae, 7 parts of the tuber of pinellia, 13 parts of Fructus Malvae Vertillatae, 11 parts of peach kernel, 4 parts of Asian puccoon, the seed of cowherb 6 parts, 13 parts of rhizoma Gastrodiae, 5 parts of the fruit of Chinese magnoliavine, 12 parts of corn stigma, 3 parts of rush, 12 parts of golden cypress, 9 parts of the tuber of dwarf lilyturf, 7 parts of Chinese violet, akebi 5 parts, 18 parts of pseudo-ginseng, 11 parts of great burdock achene, 9 parts of oriental wormwood, 4 parts of rhizoma alismatis, 6 parts of the root of kudzu vine, 12 parts of giant knotweed, 13 parts of Paris polyphylla, 4 parts of the fruit of glossy privet, 9 parts of Semen Cuscutae, 4 parts of Ramulus Taxilli, 2 parts of eclipta, 6 parts of luffa, 6 parts of sweet wormwood, 14 parts of aloe, 5 parts of benbie.
  6. 6. the Chinese medicine preparation for hemolytic reaction of being transfused blood according to any described treatments of claim 2-5, it is characterised in that:The Chinese medicine Preparation is prepared in following manner:
    (1) each medicinal material of components by weight percent described in the Chinese medicine preparation is taken, is put into marmite and fries 30 minutes~40 minutes, with crushing Machine is ground into smalls, is screened into the mesh powder of 100 mesh~200;
    (2) obtained powder in step (1) is added to the second for being 85%~90% relative to the determining alcohol of 6~8 times of mixture of powders Alcohol, it is heated to boiling reflux 3~5 hours, filters, using percolation, slowly diacolation, collection are oozed with 1~2ml per minute speed Filter liquid, relative density is 1.04~1.10 cream when 60~70 DEG C are then concentrated under reduced pressure under 0.06~0.09Mpa of vacuum Body, spray drying, 80~85 DEG C of 160~175 DEG C of EAT, the leaving air temp of spray dryer, is then ground into powder, makes Into dried cream powder;
    (3) dried cream powder made from step (2) is added into appropriate auxiliary material and granule, capsule, tablet is made.
CN201710537793.4A 2017-07-04 2017-07-04 A kind of Chinese medicine preparation for treating blood transfusion hemolytic reaction Pending CN107468920A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106389821A (en) * 2016-08-19 2017-02-15 古金龙 Traditional Chinese medicine preparation for treatment of blood transfusion hemolytic reaction and preparation method thereof
CN106728729A (en) * 2017-02-16 2017-05-31 丁瑶 A kind of clinical anesthesia Chinese medicine preparation for gastrocopy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106389821A (en) * 2016-08-19 2017-02-15 古金龙 Traditional Chinese medicine preparation for treatment of blood transfusion hemolytic reaction and preparation method thereof
CN106728729A (en) * 2017-02-16 2017-05-31 丁瑶 A kind of clinical anesthesia Chinese medicine preparation for gastrocopy

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