CN106491692A - A kind of coldrex - Google Patents
A kind of coldrex Download PDFInfo
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- CN106491692A CN106491692A CN201610964197.XA CN201610964197A CN106491692A CN 106491692 A CN106491692 A CN 106491692A CN 201610964197 A CN201610964197 A CN 201610964197A CN 106491692 A CN106491692 A CN 106491692A
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- coldrex
- dioxopromethazine
- acetaminophen
- flos lonicerae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Botany (AREA)
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- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of coldrex, feature is that it is made up of the raw material of following weight proportioning：10 1000 parts of acetaminophen, 1 100 parts of pseudoephedrine hydrochloride, 0.1 10 parts of dioxopromethazine, 5 500 parts of vitamin C, Flos Lonicerae, 20 2000 parts of the extract powder of any one or two kinds of mixture in Hemerocallis citrina Baroni, of the invention compared with existing coldrex, advantage is that prescription adopts Integrated TCM, pain relieving can be carried out by western medicine composition therein regulation nerve system of human body antipyretic, antitussive and antiasthmatic, mitigate nasal obstruction, pharyngeal congestion such as swells and ache at the symptom, the Chinese medicine ingredients such as Vc and Radix Isatidis necessary to the addition of body metabolism again, start with from autoimmunity is improved, strengthen human body to antibacterial, the resistance of the infection such as virus, treating both the principal and secondary aspects of a disease, short treating period, instant effect, toxic and side effects are little, cost is very cheap, it is a kind of preferable coldrex.
Description
Technical field
The invention belongs to flu medicine and preparation method thereof technical field, more particularly to a kind of coldrex.
Background technology
Influenza is the Acute respiratory infectious disease caused by influenza virus, and myocarditiss, pneumonia, bronchitis etc. can be caused many
Plant complication.General malaise is usually expressed as, is felt cold, had a fever, and with upper respiratory tract infection symptoms such as headache, pharyngalgia, coughs.
Have that sickness rate is high, onset is rapid, it is fast to propagate, popular wide, variability is big, infectivity is strong and with spies such as certain mortality rates
Point.
At present, the features such as Western medicine resisiting influenza virus have determined curative effect, act on accurate, but per class medicine just for influenza disease
Certain action target spot of poison works so that Western medicine is difficult to play preferably effect；And China's natural resources of Chinese medicinal materials is abundant, studies and make
With a long history, meanwhile, the features such as Chinese medicine has flu-prevention generation, many action target spots, few side effects.Chinese medicine prevention disease
Viral disease has following characteristic and advantage：1. when viral infectious disease is treated, by traditional Chinese medical science Overall View and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs
Thought is implemented wherein.On the one hand its pathological development can be analyzed by the differentiation of syndromes in seasonal febrile diseases according to four phases: WEI,QI,YING and XUE systems theory of science of epidemic febrile disease of Chinese medicine；On the other hand can
Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs by the traditional Chinese medical science is theoretical, it is understood that many set syndromic types, its Therapeutic Method are just referred to traditional square medicine.
The infected's pathological lesion can effectively be mitigated on the whole, not only emphasized eliminating evil but also paid attention to body itself to adjust.Therefore, make full use of
Chinese medicine resource, contributes to us and solves a difficult problem for influenza infection.But Chinese medicine traditional decoction is mostly using traditional decoct, its
Amount of water, decoct number of times, the factor such as decocting time clinical efficacy is affected big, while Chinese medicine decoction also have taking dose big,
The shortcomings of carrying inconvenient.Therefore, in order to meet modernization of industry of Chinese materia medica requirement, it would be desirable to develop in suitable industrialization
Medicine novel form.
Content of the invention
The purpose of the present invention is intended to the shortcoming for overcoming prior art, there is provided a kind of therapeutic effect is good, the Chinese medicine and western medicine of instant effect
In conjunction with coldrex.
The purpose of the present invention is achieved through the following technical solutions, a kind of coldrex, is characterized in, it is by following heavy
The raw material of amount proportioning is made：Acetaminophen 10-1000 parts, pseudoephedrine hydrochloride 1-100 parts, dioxopromethazine 0.1-10
Part, vitamin C 5-500 parts, extract powder 20-2000 parts of any one or two kinds of mixture in Flos Lonicerae, Hemerocallis citrina Baroni.
The preferable mix proportion scheme of each component of the present invention is：Acetaminophen 50-500 parts, pseudoephedrine hydrochloride 10-60
Part, dioxopromethazine 1-5 parts, Catergen 0-200 parts, the extract powder of any one or two kinds of mixture in Flos Lonicerae, Hemerocallis citrina Baroni
100-1000 parts.
Each component optimum proportion scheme of the present invention is：400 parts of acetaminophen, 40 parts of pseudoephedrine hydrochloride, dioxy third
2 parts of piperazine, 100 parts of vitamin C, 400 parts of the extract powder of any one or two kinds of mixture in Flos Lonicerae, Hemerocallis citrina Baroni.
In medicament of the present invention, the pharmacological property of each component is：Acetaminophen, white crystals or crystalline powder, nothing
Smelly, mildly bitter flavor is fast and effectively antipyretic analgesic, and it can suppress the synthesis of prostaglandin, be produced by maincenter and periphery
Analgesic effect, produces refrigeration function by acting on the thermotaxic centre of hypothalamuss；Clinic is mainly used in having a headache, generates heat
And multiple pain, it is also applied for the caused headache of common cold and virus infection, throat pain, heating and general malaise.
Pseudoephedrine hydrochloride, white crystal or crystalline powder, odorless, bitter in the mouth is Beta-3 adrenergic receptor agonists,
Upper respiratory tract mucosa blood capillary is shunk optionally, is mitigated nose, pharyngeal mucosa hyperemia, is alleviated the symptoms such as nasal obstruction, watery nasal discharge.
Dioxopromethazine, also known as dioxopromethazine, white or micro-yellow powder or crystalline powder, odorless, bitter in the mouth.Have stronger
Antitussive effect, and there is resistance amine, release smooth muscle spasm, antiinflammatory drawn game anaesthetic effect.Clinical practice energy antitussive, relieving asthma,
Antiallergic, mitigates the symptoms such as cough, asthma uncomfortable in chest, itching of the throat, rhinocnesmus, sneeze, can be used to treat chronic bronchitiss, anaphylaxis
Asthma, allergic bronchitises etc..Have no drug resistance and additive.
Vitamin C, also known as ascorbic acid, when human body lacks, easily cause various anemias, aphtha, flu etc..Supplement during flu
Resistance of the Vc energy enhancing body to infection such as antibacterial, viruses.
Flos Lonicerae, Hemerocallis citrina Baroni, are the root and leaf of same plant, bitter in the mouth, tremble with fear, GUIXIN, stomach.Both act on similar, heat clearing away solution
Poison, antiviral cure cold, and have certain inhibitory action to various bacteria (such as bacillus subtilis, staphylococcus aureuses etc.).Clinical
It is usually used in treating laryngopharynx swelling and pain, tonsillitiss, bronchitis, pneumonia etc. that flu causes.
Of the invention most apparent advantage is that prescription adopts Integrated TCM compared with existing ground coldrex, which can be passed through
In western medicine composition adjust nerve system of human body antipyretic, the antitussive and antiasthmatic that carries out pain relieving, mitigate nasal obstruction, pharyngeal congestion and the disease such as swell and ache
Shape, the Chinese medicine ingredients such as Vc and Flos Lonicerae necessary to the addition of body metabolism again are started with from autoimmunity is improved, strengthen human body
Resistance to infection such as antibacterial, viruses, treating both the principal and secondary aspects of a disease, short treating period, instant effect, in component without P P A (phenylpropanolamine),
Caffeine and Morphinoid drug, toxic and side effects are little, will not produce drug dependence.Good effect of the present invention, cost are very cheap, are
A kind of preferable coldrex.
Specific embodiment
In order that technical problem solved by the invention, technical scheme and beneficial effect become more apparent, below in conjunction with
Embodiment, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only in order to explaining this
Invention, is not intended to limit the present invention.
Embodiment 1, takes finished product acetaminophen powder 10kg, pseudoephedrine hydrochloride powder 1kg, dioxopromethazine powder
0.1kg, vitamin C 5kg, Hemerocallis citrina Baroni extract powder 20kg (making of extract powder is herbal pharmaceutical conventional process), mix homogeneously is pressed
Conventional manner technique makes tablet, every 0.5g, mounted box packaging.
Embodiment 2, takes finished product acetaminophen powder 1000kg, pseudoephedrine hydrochloride powder 100kg, dioxopromethazine powder
Last 10kg, vitamin C 500kg, Hemerocallis citrina Baroni and Flos Lonicerae (herb) extract powder 2000kg, mix homogeneously, routinely pharmaceutical technology system
Into capsule, every 0.5g, mounted box packaging.
Embodiment 3, takes finished product acetaminophen powder 50kg, pseudoephedrine hydrochloride powder 10kg, dioxopromethazine powder
1kg, Catergen 0kg, Flos Lonicerae extractum powder 100kg, mix homogeneously, routinely pharmaceutical technology make tablet, every 0.5g, dress
Box packaging.
Clinical observation on the therapeutic effect data：
First, treatment target：The cold patients that many reasons such as common cold, influenza (viral influenza) cause,
It is mainly shown as heating, headache, nasal obstruction, rhinorrhea, cough, laryngopharynx swelling and pain etc..
2nd, Therapeutic Method：In, patients with mild, each 2-3 grains of tablet (or capsule), or electuary 1 bag every time, three times a day,
It is within three days a course for the treatment of；Yellow viscous expectorant, the patient with severe symptoms of abundant expectoration is coughed, plus anti-inflammatory treatment is given with antibiotic.Child, according to age and disease
Feelings weight, decrement are taken.
3rd, curative effect determinate standard：1st, fully recover：Various cold symptoms substantially disappear, and stopping three days or so is not recurred；2nd, good
Turn：Various cold symptoms mitigate more than 1/2；3rd, invalid：Various diseases have no improvement.
4th, case selection：Clinical practice for many years, treats the over thousands of people of various patients to this prescription, now randomly selects a year
Interior patient 100, the age between 5-70 year, male 50, women 50.
5th, model case：
Case 1, a ××, female are 40 years old, January 20 2002 first visit date, dizzy heavy, 38.4 DEG C of body temperature, acid from head to foot
Bitterly, slight cough, without expectorant, the state of an illness is in a couple of days.Give and take our tablet, 3 tablets once, 3 times a day, multiple after serveing on three days
Examine, patient mental is very good, various cold symptoms all disappear, which is accused after inquiring halve again to take and be discontinued two days later, note protecting
Warm, observe nearly Zhou Weijian flu recurrence.
Case 2, in ×, female, 12 years old, April 6 2002 first visit date, influenza, laryngopharynx swelling and pain, cough, nose
Plug, 39 DEG C of body temperature are taken contac two days, are not improved.Give and take our electuary, every time 1 bag, 3 times a day, serve on three days
Further consultation afterwards, patient's sore throat are disappeared substantially, are not coughed, and a little clear nasal mucus of stream, body temperature are normal, advise which to take three days again, and every time 1
Bag, 2 times a day, and further consultation again after drug withdrawal, cold symptoms all disappear, and observation had no recurrence in one week.
Case 3, in ××, man, 38 years old, April 8 2002 first visit date, influenza, distending pain in the head had a stuffy nose, whole body
Discomfort, 38.7 DEG C of body temperature.Give and take our tablet, 3 tablets once, 3 times a day, serve on three days, patient's headache is disappeared substantially,
BITONG clear nasal discharge, body temperature are normal, then take medicine three days, further consultation, and body is fully recovered, and observation had no recurrence in one week.
Presently preferred embodiments of the present invention is the foregoing is only, not in order to limit the present invention, all in essence of the invention
Any modification, equivalent and improvement that is made within god and principle etc., should be included within the scope of the present invention.
Claims (3)
1. a kind of coldrex, it is characterised in that it is made up of the raw material of following weight proportioning：Acetaminophen 10-
1000 parts, pseudoephedrine hydrochloride 1-100 parts, dioxopromethazine 0.1-10 parts, vitamin C 5-500 parts, appointing in Flos Lonicerae, Hemerocallis citrina Baroni
Extract powder 20-2000 parts of one or two mixture.
2. according to a kind of coldrex described in claim 1, it is characterised in that each group distribution ratio content is：Acetaminophen
50-500 parts, pseudoephedrine hydrochloride 10-60 parts, dioxopromethazine 1-5 parts, Catergen 0-200 parts, appointing in Flos Lonicerae, Hemerocallis citrina Baroni
Extract powder 100-1000 parts of one or two mixture.
3. according to a kind of coldrex described in claim 1, it is characterised in that each group distribution ratio content is：Acetaminophen
400 parts, 40 parts of pseudoephedrine hydrochloride, 2 parts of dioxopromethazine, 100 parts of vitamin C, any one or two kinds of in Flos Lonicerae, Hemerocallis citrina Baroni are mixed
400 parts of the extract powder of compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610964197.XA CN106491692A (en) | 2016-11-04 | 2016-11-04 | A kind of coldrex |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610964197.XA CN106491692A (en) | 2016-11-04 | 2016-11-04 | A kind of coldrex |
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| Publication Number | Publication Date |
|---|---|
| CN106491692A true CN106491692A (en) | 2017-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610964197.XA Pending CN106491692A (en) | 2016-11-04 | 2016-11-04 | A kind of coldrex |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109833403A (en) * | 2017-11-24 | 2019-06-04 | 徐彩玲 | A kind of formula of cold drug |
-
2016
- 2016-11-04 CN CN201610964197.XA patent/CN106491692A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109833403A (en) * | 2017-11-24 | 2019-06-04 | 徐彩玲 | A kind of formula of cold drug |
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| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170315 |