CN108079076B - Traditional Chinese medicine chewing gum for treating kidney deficiency type loose and loose teeth and preparation method thereof - Google Patents
Traditional Chinese medicine chewing gum for treating kidney deficiency type loose and loose teeth and preparation method thereof Download PDFInfo
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- CN108079076B CN108079076B CN201711456106.2A CN201711456106A CN108079076B CN 108079076 B CN108079076 B CN 108079076B CN 201711456106 A CN201711456106 A CN 201711456106A CN 108079076 B CN108079076 B CN 108079076B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
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- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
Abstract
The invention relates to the field of chewing gums, and in particular relates to a traditional Chinese medicine chewing gum for treating kidney deficiency type loose and floating teeth and a preparation method thereof. The composition is prepared from the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 30-60 parts of processed monkshood, 30-50 parts of fructus psoraleae, 30-60 parts of gypsum, 10-30 parts of mint leaves and 30-60 parts of halite. The traditional Chinese medicine chewing gum for treating or preventing the deficiency of the kidney type loose and loose teeth and the loss in the prior art is supplemented, participates in the body fluid environment circulation of a human body to a certain extent, strengthens the kidney function, and improves the restoration capacity of gingival cells, so that the effects of strengthening teeth and preventing loss are achieved.
Description
Technical Field
The invention relates to the field of chewing gums, and in particular relates to a traditional Chinese medicine chewing gum for treating kidney deficiency type loose and floating teeth and a preparation method thereof.
Background
Tooth loosening is a disease very common in the elderly, and has been gradually advancing toward the direction of younger people in recent years. The tooth loosening not only affects the normal chewing function of the human body, but also can cause deep dental diseases, gastrointestinal diseases and even can induce various visceral diseases. The loose teeth seriously affect the physical and mental health and the life quality of the human body.
The traditional Chinese medicine considers that the kidney governs bones, the teeth are the rest of bones, the kidney qi is weak, the essence is deficient, the teeth are out of nourishment, and the teeth are shaken due to the insecurity of the teeth. For example, it is mentioned in nan Song & Yang ShiYing (Renzhai Zhi Fang): the nourishing of the marrow and the kidney-excess are the main factors of the tooth, bone and marrow. Therefore, kidney failure breaks the teeth open and essence is preponderant, causing the teeth to be hard. For this reason, kidney failure can lead to tooth deficiency, while essence can lead to tooth stiffness, and kidney qi deficiency is mainly indicated for kidney qi deficiency, because teeth are brittle and not firm, or easy to shake or loose. The Ming and Yu Biu & Ling & lt & ltmedical science formal & gt proposes: "either mean pain and tooth shaking, or mean pain and insect erosion, and also mean that there is inconvenience in eating and drinking due to the gap between teeth. For the patients with the large gingival atrophy and fluctuation, it is essential to nourish yin and tonify kidney for kidney-essence deficiency.
The invention patent with application number 201210235845.X 'a traditional Chinese medicine chewing gum' (application date: 2012.06.29) introduces a traditional Chinese medicine chewing gum. The product is prepared from paeonia ostii, mint, agastache rugosus, green tea, Arabic gum and other gum bases. Has effects of refreshing brain and relieving fatigue. But can not play a role in the symptoms of tooth loosening and falling caused by the kidney deficiency.
The invention patent with application number 201410363586.8, anti-dental caries chewing gum (application date: 2014.07.29), describes a traditional Chinese medicine chewing gum. The product is prepared from fructus Siraitiae Grosvenorii, Glycyrrhrizae radix, Galla chinensis, radix Angelicae Dahuricae, herba Menthae, flos Caryophylli, folium Nelumbinis, and cortex Magnolia officinalis. The product has effect in directly killing Streptococcus mutans cells. But can not play a role in the symptoms of tooth loosening and falling caused by the kidney deficiency.
The invention patent with application number 201410036091.4, a traditional Chinese medicine desensitization bamboo salt chewing gum and a preparation method thereof (application date: 2014.01.24), introduces a traditional Chinese medicine chewing gum. The product is prepared from sea salt, calcined oyster shell, rhizoma drynariae, radix rehmanniae, indigo naturalis, coptis chinensis extract and sweetener neotame. It can clean oral cavity, keep breath fresh, block dentinal tubule, and treat dentin hypersensitivity. But can not play a role in the symptoms of tooth loosening and falling caused by the kidney deficiency.
The mainstream chewing gum Yida in the market is prepared from xylitol, maltitol, gum base, thickening agent, sorbitol, spice, D-mannitol, acidity regulator, phospholipid, sweetener, titanium dioxide, coating agent, acesulfame potassium, antioxidant and the like. The main functions are that it can refresh breath and clean teeth. However, the product uses various sweeteners, and is not beneficial to teeth and body after long-term consumption. Meanwhile, the medicine is also ineffective in treating the symptoms of tooth loosening and falling caused by kidney deficiency.
Disclosure of Invention
One of the purposes of the invention is to provide the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and fallen teeth, which supplements the blank of the traditional Chinese medicine chewing gum for treating or preventing the deficiency of the kidney type loose and fallen teeth in the prior art, improves the safety of the chewing gum and has no toxic or side effect on human bodies; to a certain extent, the medicine participates in the circulation of the body fluid environment of a human body, strengthens the function of the kidney and improves the repair capability of gingival cells, thereby achieving the efficacy of fixing teeth and preventing dropping.
The invention also aims to provide a preparation method of the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the falling teeth, which combines a traditional Chinese medicine formula with a scientific and technical means preparation method, extracts effective components to the maximum extent, improves the efficacy of the traditional Chinese medicine, degrades the toxic alkaloid of the processed aconite in the formula without losing the treatment effect, and improves the utilization rate and the use effect of the effective active components in the formula.
The first scheme is as follows:
a traditional Chinese medicinal chewing gum for treating deficiency of the kidney type loose and loose teeth comprises radix Aconiti lateralis Preparata, fructus Psoraleae, Gypsum Fibrosum, folium Menthae and Halitum.
Preferably, the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation is characterized in that: the traditional Chinese medicine composition comprises, by weight, 30-60 parts of processed monkshood, 30-50 parts of fructus psoraleae, 30-60 parts of gypsum, 10-30 parts of mint leaves and 30-60 parts of halite.
Preferably, the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation comprises the following components in parts by weight: 40-50 parts of rhizoma typhonii, 35-45 parts of fructus psoraleae, 40-50 parts of gypsum, 15-25 parts of mint leaves and 40-50 parts of halite.
Scheme II:
a preparation method of a traditional Chinese medicine chewing gum for treating kidney deficiency type teeth loose and drop comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) softening the gum base for later use;
(5) mixing the dry extract powder, volatile oil, fermented powder, Halitum, gum base and adjuvants, and making into chewing gum.
Preferably, the mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d,the screening mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
Preferably, the mass ratio of the rhizoma typhonii powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilization temperature is 110 ℃, the sterilization time is 43min, the inoculated strain is trametes cinnabarina, the fermentation temperature is 30 ℃, the fermentation humidity is 60%, the fermentation time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
Preferably, the gum base softening treatment method comprises the following steps: and (3) softening 300-800 parts of the gum base for 5-10 hours at the temperature of 60-80 ℃.
Preferably, the auxiliary materials are glycerol and sodium carboxymethyl cellulose.
The preparation type is chewing gum.
Preferably, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
Scheme II:
compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine chewing gum for treating or preventing the teeth loose and shed due to the deficiency of the kidney supplements the blank of the traditional Chinese medicine chewing gum for treating or preventing the teeth loose and shed due to the deficiency of the kidney in the prior art, improves the safety of spraying, has no toxic or side effect on human bodies, participates in the environmental circulation of body fluid of the human bodies to a certain extent, strengthens the function of the kidney, improves the restoration capacity of gingival cells, and achieves the effects of strengthening teeth and shedding.
2. The active effective components of the aconite tuber, such as alkaloid, are retained by a fermentation method, toxic substances are removed, the effective utilization rate of the aconite tuber is improved, the self-repairing capability of gingival cells is stimulated, and secondary damage to gingiva, an organism and the like caused by treatment is avoided, so that the gingiva is repaired, and the teeth are fixed and are prevented from falling off.
3. By adopting pure natural plant raw materials, all effective components of the product are controlled within a range which can be tolerated by human bodies, and the product has high safety evaluation.
4. Combines the traditional Chinese medicine formula with scientific and technical means, extracts effective components to the maximum extent, improves the efficacy of the traditional Chinese medicine, and is convenient for popularization and use.
5. The formula is prepared by taking the theory of traditional Chinese medicine as guidance and taking careful prescription. The recipe of Zhong Pao Fu Zi is pungent, sweet and hot, and good at tonifying fire and supporting yang, and restoring yang and rescuing collapse, it is the monarch herb. Bu Gu Zhi is pungent, bitter and warm in property, can warm kidney and strengthen yang, receive qi and check diarrhea, and strengthen the effect of Bu Fu Zi in tonifying kidney and strengthening yang, which is the ministerial drug. Radix Aconiti lateralis Preparata and fructus Psoraleae are warm-heat products, and Gypsum Fibrosum, with sweet, pungent and cold natures, has effects of clearing heat and fire, relieving restlessness and quenching thirst; the mint is pungent and cool, can disperse wind-heat, has the function of clearing head and eyes, and can relieve the warm nature of the processed aconite and the psoralea, and the two medicines are adjuvant medicines. Da Qing Yan is salty and cold, enters heart and kidney meridians to cool blood and improve vision, so it is used as a guide to meridian. The medicines are combined to play the effects of warming the kidney, absorbing qi, strengthening the teeth and preventing alopecia.
6. Clinical application and pharmacological experiments prove that the medicament has obvious treatment effect and definite curative effect on the loose and fallen teeth, and particularly has obvious curative effect on the symptom of the loose and fallen teeth caused by kidney deficiency.
7. Effective components in the traditional Chinese medicine are fully released through chewing action, and meanwhile, due to the plastic property of the chewing gum, the contact surface area of the chewing gum with teeth and gum can be fully enlarged, so that the medicine fully exerts the effect, and the effects of fixing teeth and preventing alopecia are achieved.
8. The effective active ingredients of the traditional Chinese medicine chewing gum are all derived from natural products, are green and healthy, and have excellent curative effect on the deficiency of the kidney type loose and fallen teeth.
9. Compared with the prior art, the invention has the following beneficial effects:
the specific implementation mode is as follows:
a traditional Chinese medicinal chewing gum for treating deficiency of the kidney type loose and loose teeth comprises radix Aconiti lateralis Preparata, fructus Psoraleae, Gypsum Fibrosum, folium Menthae and Halitum.
Wherein the processed radix Aconiti lateralis is dried radix Aconiti lateralis Preparata of Aconitum carmichaeli Debx of Ranunculaceae; pungent, sweet and warm in flavor; entering heart, spleen and kidney meridians; reviving yang, rescuing from collapse, supplementing fire and supporting yang;
fructus Psoraleae is dried mature fruit of Psoralea corylifolia L. of Leguminosae; pungent and bitter taste, warm nature; entering kidney and spleen meridians; warming kidney and tonifying yang, receiving qi and checking diarrhea;
gypsum, which is sulfate mineral anhydrite gypsum family gypsum; sweet and pungent in flavor and cold in nature; entering lung and stomach meridians; clearing heat and purging fire, relieving restlessness and quenching thirst;
mint leaf, which is dried leaf of Mentha haplocalyx Briq. of Labiatae; pungent taste and cool nature; entering lung and liver meridians; disperse wind-heat, clear head and eyes, promote eruption;
halite, which is a halide rock salt lake salt crystal; salty taste and cold nature; entering heart and kidney meridians; cool blood, improve vision.
Preferably, the traditional Chinese medicine chewing gum for treating the kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 30-60 parts of processed monkshood, 30-50 parts of fructus psoraleae, 30-60 parts of gypsum, 10-30 parts of mint leaves and 30-60 parts of halite.
Preferably, the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation comprises the following components in parts by weight: 40-50 parts of rhizoma typhonii, 35-45 parts of fructus psoraleae, 40-50 parts of gypsum, 15-25 parts of mint leaves and 40-50 parts of halite.
A preparation method of a traditional Chinese medicine chewing gum for treating kidney deficiency type teeth loosening and falling off,
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) softening the gum base for later use;
(5) mixing the dry extract powder, volatile oil, fermented powder, Halitum, gum base and adjuvants, and making into chewing gum.
Further, the mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the screening mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
Furthermore, the mass ratio of the rhizoma typhonii powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilization temperature is 110 ℃, the sterilization time is 43min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 30 ℃, the fermentation humidity is 60%, the fermentation time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
Further, the gum base softening treatment method comprises the following steps: and (3) softening 300-800 parts of the gum base for 5-10 hours at the temperature of 60-80 ℃.
Furthermore, the auxiliary materials are glycerol and sodium carboxymethyl cellulose.
Further, the formulation type is chewing gum.
Further, the loose and loose teeth are in the form of kidney deficiency.
Example 1:
a traditional Chinese medicine chewing gum for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 45 parts of processed monkshood, 30 parts of fructus psoraleae, 60 parts of gypsum, 20 parts of mint leaves and 30 parts of halite.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 80 mesh sieve, adding 20 times of purified water, homogenizing under 0.25Mpa for 5min, sterilizing at 120 deg.C for 43 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 20 ℃, the fermentation humidity is 75%, and the fermentation time is 33 d. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 80 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 5 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is set to be 60L/h, the temperature is 35 ℃, the pressure is 20MPa, and the extraction time is 80min each time to obtain volatile oil for later use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 7 times of purified water, carrying out reflux extraction for 3 times, each time for 30min, filtering, carrying out vacuum concentration, concentrating the liquid medicine to a specific gravity of 1.25 at a concentration temperature of 50 ℃ and a vacuum degree of-0.08 Mpa to obtain a concentrated solution, drying the concentrated solution to obtain dry paste, crushing the dry paste, and sieving the dry paste with a 80-mesh sieve to obtain dry paste powder for later use;
(4) and (3) softening 300 parts of gum base for 10 hours at 70 ℃.
(5) Mixing the dry extract powder, volatile oil, fermented powder, Halitum, gum base and adjuvants, and making into chewing gum.
Furthermore, the auxiliary materials are glycerol and sodium carboxymethyl cellulose.
Further, the formulation type is chewing gum.
Further, the loose and loose teeth are in the form of kidney deficiency.
Example 2:
a traditional Chinese medicine chewing gum for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 60 parts of processed monkshood, 40 parts of fructus psoraleae, 30 parts of gypsum, 20 parts of mint leaves and 30 parts of halite.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 100 mesh sieve, adding 5 times of purified water, homogenizing under 0.35Mpa for 10min, sterilizing at 100 deg.C for 55 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 30 ℃, the fermentation humidity is 45%, and the fermentation time is 45 d. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 100 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 5 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is set to be 20L/h, the temperature is 37 ℃, the pressure is 70MPa, and the extraction time is 30min each time to obtain volatile oil for later use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 8 times of purified water, carrying out reflux extraction for 3 times, each time for 30min, filtering, carrying out vacuum concentration, concentrating the liquid medicine to obtain concentrated solution, drying the concentrated solution to obtain dry paste, crushing the dry paste, and sieving the dry paste with a 100-mesh sieve to obtain dry paste powder for later use, wherein the vacuum degree of the concentration is-0.1 Mpa, and the concentration temperature is 75 ℃;
(4) and (3) softening 500 parts of gum at 80 ℃ for 5 hours.
(5) Mixing the dry extract powder, volatile oil, fermented powder, Halitum, gum base and adjuvants, and making into chewing gum.
Furthermore, the auxiliary materials are glycerol and sodium carboxymethyl cellulose.
Further, the formulation type is chewing gum.
Further, the loose and loose teeth are in the form of kidney deficiency.
Example 3:
a traditional Chinese medicine chewing gum for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 30 parts of processed monkshood, 50 parts of fructus psoraleae, 45 parts of gypsum, 10 parts of mint leaves and 60 parts of halite.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 100 mesh sieve, adding 13 times of purified water, homogenizing under 0.15Mpa for 15min, sterilizing at 110 deg.C for 30 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 40 ℃, the fermentation humidity is 60%, and the fermentation time is 20 days. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 200 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 7 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is 40L/h, the temperature is 32 deg.C, the pressure is 70MPa, and the extraction time is 55min each time to obtain volatile oil for use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 10 times of purified water, carrying out reflux extraction for 3 times, 40min each time, filtering, carrying out vacuum concentration, wherein the vacuum degree of concentration is-0.05 Mpa, the concentration temperature is 100 ℃, concentrating the liquid medicine to the specific gravity of 1.13 to obtain concentrated solution, drying to obtain dry paste, crushing, and sieving by a 130-mesh sieve to obtain dry paste powder for later use;
(4) and (3) softening 800 parts of gum base at 60 ℃ for 7.5 h.
(5) Mixing the dry extract powder, volatile oil, fermented powder, Halitum, gum base and adjuvants, and making into chewing gum.
Furthermore, the auxiliary materials are glycerol and sodium carboxymethyl cellulose.
Further, the formulation type is chewing gum.
Further, the loose and loose teeth are in the form of kidney deficiency.
The reliability and safety of the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the falling teeth produced in the embodiment 1 to the embodiment 3 of the invention completely meet the requirements of the national relevant standards through detection, and the clinical treatment examples are as follows:
although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A traditional Chinese medicine chewing gum for treating kidney deficiency type loose and shed teeth is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 30-60 parts of processed monkshood, 30-50 parts of fructus psoraleae, 30-60 parts of gypsum, 10-30 parts of mint leaves and 30-60 parts of halite.
2. The traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation according to claim 1 is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 40-50 parts of rhizoma typhonii, 35-45 parts of fructus psoraleae, 40-50 parts of gypsum, 15-25 parts of mint leaves and 40-50 parts of halite.
3. The traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation according to claim 1 is characterized in that: the preparation method of the traditional Chinese medicine chewing gum comprises the following steps,
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) softening the gum base for later use;
(5) mixing the dry extract powder, volatile oil, fermented powder, Halitum with gum base and adjuvants, and making into chewing gum;
the processed radix Aconiti lateralis powder and its purificationThe mass ratio of water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieve mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
4. The preparation method of the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation according to claim 3, which is characterized in that: the mass ratio of the processed aconite powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilizing temperature is 110 ℃, the sterilizing time is 43min, the inoculated strain is trametes cinnabarinus, the fermenting temperature is 30 ℃, the fermenting humidity is 60%, the fermenting time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
5. The preparation method of the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation according to claim 3, which is characterized in that: the gum base softening treatment method comprises the following steps: and (3) softening 300-800 parts of the gum base for 5-10 hours at the temperature of 60-80 ℃.
6. The preparation method of the traditional Chinese medicine chewing gum for treating the deficiency of the kidney type loose and loose teeth and the exfoliation according to claim 3, which is characterized in that: the auxiliary materials are glycerol and sodium carboxymethyl cellulose.
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