CN108030732B - Traditional Chinese medicine toothpaste for treating kidney deficiency type loose and floating tooth and preparation method thereof - Google Patents
Traditional Chinese medicine toothpaste for treating kidney deficiency type loose and floating tooth and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention belongs to the field of oral care, and particularly relates to traditional Chinese medicine toothpaste for treating kidney deficiency type loose and floating tooth and falling and a preparation method thereof. The traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and loose teeth and the falling comprises the following components in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves. The composition is extracted by related technologies, and then is mixed with auxiliary materials to prepare toothpaste for clinical use. Clinical application and pharmacological experiments prove that the medicament has obvious treatment effect and definite curative effect on the loose and loose teeth and the falling teeth, and particularly has obvious curative effect on the loose and fallen teeth symptom caused by kidney deficiency.
Description
Technical Field
The invention belongs to the field of oral care, and particularly relates to traditional Chinese medicine toothpaste for treating kidney deficiency type loose and floating tooth and falling and a preparation method thereof.
Background
Tooth loosening is a disease very common in the elderly, and has been gradually advancing toward the direction of younger people in recent years. The tooth loosening not only affects the normal chewing function of the human body, but also can cause deep dental diseases, gastrointestinal diseases and even can induce various visceral diseases. The loose teeth seriously affect the physical and mental health and the life quality of the human body.
The traditional Chinese medicine considers that the kidney governs bones, the teeth are the rest of bones, the kidney qi is weak, the essence is deficient, the teeth are out of nourishment, and the teeth are shaken due to the insecurity of the teeth. For example, it is mentioned in nan Song & Yang ShiYing (Renzhai Zhi Fang): the nourishing of the marrow and the kidney-excess are the main factors of the tooth, bone and marrow. Therefore, kidney failure breaks the teeth open and essence is preponderant, causing the teeth to be hard. For this reason, kidney failure can lead to tooth deficiency, while essence can lead to tooth stiffness, and kidney qi deficiency is mainly indicated for kidney qi deficiency, because teeth are brittle and not firm, or easy to shake or loose. The Ming and Yu Biu & Ling & lt & ltmedical science formal & gt proposes: "either mean pain and tooth shaking, or mean pain and insect erosion, and also mean that there is inconvenience in eating and drinking due to the gap between teeth. For the patients with the large gingival atrophy and fluctuation, it is essential to nourish yin and tonify kidney for kidney-essence deficiency. "
The invention patent with application number of 201611060243.X discloses a traditional Chinese medicine toothpaste (application date: 2016.11.28). The traditional Chinese medicine toothpaste is prepared from radix Aconiti lateralis Preparata 1-4 parts, sea salt 1-4 parts, herba asari 2-5 parts, radix Saposhnikoviae 1.5-4 parts, semen Phaseoli 1.5-4 parts, herba Menthae 2-6 parts, fructus Ligustri Lucidi 1-4 parts, Ecliptae herba 2-5 parts by toothpaste process, and has the advantages of limited use as toothpaste, single function, and no toothpaste preparation process.
The invention patent with application number 201310705355.6, a traditional Chinese medicine toothpaste (application date: 2013.12.20), introduces a traditional Chinese medicine toothpaste. The product is prepared from conventional toothpaste materials such as lung-regulating powder, herba gypsophilae, polyoxyethylene lauryl ether sodium sulfate and the like, has weak medicinal effect, is used for enhancing the foaming effect, and provides the process only by a traditional Chinese medicine decocting mode.
At present, most varieties of toothpaste focus on tooth cleaning and breath freshening, but the problem of loose teeth caused by kidney deficiency is not brought forward.
Disclosure of Invention
To solve the problems set forth in the background art described above,
the invention aims to provide the traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and floating teeth and falling teeth, which fills the blank of the traditional Chinese medicine toothpaste for treating or preventing the deficiency of the kidney type loose and floating teeth and falling teeth in the prior art, improves the safety of the toothpaste, has no toxic or side effect on human bodies, has obvious treatment effect on the loose and floating teeth and falling teeth and definite curative effect, and particularly has obvious curative effect on the loose and floating teeth and falling teeth symptoms caused by the deficiency of the kidney.
The invention also aims to provide a preparation method of the traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and loose teeth and the loss.
In order to achieve the purpose, the invention provides the following technical scheme:
the first scheme is as follows:
a Chinese medicinal toothpaste for treating deficiency of the kidney type loose and loose teeth and exfoliation comprises radix Aconiti lateralis Preparata, Halitum, fructus Psoraleae, Gypsum Fibrosum and folium Menthae.
The traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and loose teeth and the falling teeth comprises the following components in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves.
Preferably, the traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and floating teeth and the falling teeth comprises the following components in parts by weight: 30-80 parts of radix aconiti praeparata, 30-80 parts of halitum, 30-60 parts of fructus psoraleae, 30-80 parts of gypsum and 15-35 parts of mint leaves.
Preferably, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
Scheme II:
a preparation method of traditional Chinese medicine toothpaste for treating kidney deficiency type loose and loose teeth and exfoliation comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into toothpaste.
The mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieving mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of the gypsum and the fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, and the concentration temperature is highThe temperature is 50-100 ℃, and the liquid medicine is concentrated to the specific gravity of 1.00-1.25.
Preferably, the mass ratio of the rhizoma typhonii powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilization temperature is 110 ℃, the sterilization time is 43min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 30 ℃, the fermentation humidity is 60%, the fermentation time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
Preferably, the auxiliary materials comprise sodium carboxymethylcellulose, propylene glycol, silicon dioxide, sodium lauroyl sarcosine, stannous fluoride, chlorophyll and honey.
Preferably, the preparation method of the traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and floating teeth and falling off is characterized by comprising the following steps: the preparation type is ointment.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and loose teeth and exfoliation fills the blank of the traditional Chinese medicine toothpaste for treating or preventing the deficiency of the kidney type loose and exfoliation teeth in the prior art, improves the safety of the toothpaste, has no toxic or side effect on human bodies, has obvious treatment effect on the loose and exfoliation teeth and exact treatment effect, and particularly has obvious treatment effect on the loose and exfoliation teeth symptoms caused by the deficiency of the kidney.
2. The active effective components of the aconite tuber, such as alkaloid, are retained by a fermentation method, toxic substances are removed, the effective utilization rate of the aconite tuber is improved, the self-repairing capability of gingival cells is stimulated, and secondary damage to gingiva, an organism and the like caused by treatment is avoided, so that the gingiva is repaired, and the teeth are fixed and are prevented from falling off.
3. By adopting pure natural plant raw materials, all effective components of the product are controlled within a range which can be tolerated by human bodies, and the product has high safety evaluation.
4. Combines the traditional Chinese medicine formula with scientific and technical means, extracts effective components to the maximum extent, improves the efficacy of the traditional Chinese medicine, and is convenient for popularization and use.
5. The formula is prepared by taking the theory of traditional Chinese medicine as guidance and taking careful prescription. The recipe of Zhong Pao Fu Zi is pungent, sweet and hot, and good at tonifying fire and supporting yang, and restoring yang and rescuing collapse, it is the monarch herb. Bu Gu Zhi is pungent, bitter and warm in property, can warm kidney and strengthen yang, receive qi and check diarrhea, and strengthen the effect of Bu Fu Zi in tonifying kidney and strengthening yang, which is the ministerial drug. Radix Aconiti lateralis Preparata and fructus Psoraleae are warm-heat products, and Gypsum Fibrosum, with sweet, pungent and cold natures, has effects of clearing heat and fire, relieving restlessness and quenching thirst; the mint is pungent and cool, can disperse wind-heat, has the function of clearing head and eyes, and can relieve the warm nature of the processed aconite and the psoralea, and the two medicines are adjuvant medicines. Da Qing Yan is salty and cold, enters heart and kidney meridians to cool blood and improve vision, so it is used as a guide to meridian. The medicines are combined to play the effects of warming the kidney, absorbing qi, strengthening the teeth and preventing alopecia.
6. Clinical application and pharmacological experiments prove that the medicament has obvious treatment effect and definite curative effect on the loose and fallen teeth, and particularly has obvious curative effect on the symptom of the loose and fallen teeth caused by kidney deficiency.
7. Compared with the prior art, the invention has the following beneficial effects:
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
A Chinese medicinal toothpaste for treating deficiency of the kidney type loose and loose teeth and exfoliation comprises radix Aconiti lateralis Preparata, Halitum, fructus Psoraleae, Gypsum Fibrosum and folium Menthae.
Wherein the processed radix Aconiti lateralis is dried radix Aconiti lateralis Preparata of Aconitum carmichaeli Debx of Ranunculaceae; pungent, sweet and warm in flavor; entering heart, spleen and kidney meridians; reviving yang, rescuing from collapse, supplementing fire and supporting yang;
fructus Psoraleae is dried mature fruit of Psoralea corylifolia L. of Leguminosae; pungent and bitter taste, warm nature; entering kidney and spleen meridians; warming kidney and tonifying yang, receiving qi and checking diarrhea;
gypsum, which is sulfate mineral anhydrite gypsum family gypsum; sweet and pungent in flavor and cold in nature; entering lung and stomach meridians; clearing heat and purging fire, relieving restlessness and quenching thirst;
mint leaf, which is dried leaf of Mentha haplocalyx Briq. of Labiatae; pungent taste and cool nature; entering lung and liver meridians; disperse wind-heat, clear head and eyes, promote eruption;
halite, which is a halide rock salt lake salt crystal; salty taste and cold nature; entering heart and kidney meridians; cool blood, improve vision.
Further, the traditional Chinese medicine toothpaste for treating the kidney deficiency type loose and floating tooth and falling off comprises the following components in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves.
Further, the traditional Chinese medicine toothpaste for treating the kidney deficiency type loose and floating tooth and falling off comprises the following components in parts by weight: 30-80 parts of radix aconiti praeparata, 30-80 parts of halitum, 30-60 parts of fructus psoraleae, 30-80 parts of gypsum and 15-35 parts of mint leaves.
A preparation method of traditional Chinese medicine toothpaste for treating kidney deficiency type loose and loose teeth and exfoliation comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving with 100 mesh sieve to obtain dry extract powder;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into toothpaste.
Further, the mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieving mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; gypsum Fibrosum and fructus Psoraleae concentrated extractThe degree of vacuum is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50 ℃ to 100 ℃, and the liquid medicine is concentrated to the specific gravity of 1.00 ℃ to 1.25.
Furthermore, the mass ratio of the rhizoma typhonii powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilization temperature is 110 ℃, the sterilization time is 43min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 30 ℃, the fermentation humidity is 60%, the fermentation time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
Further, the auxiliary materials comprise sodium carboxymethylcellulose, propylene glycol, silicon dioxide, sodium lauroyl sarcosine, stannous fluoride, chlorophyll and honey.
Further, the preparation type is ointment.
Further, the loose and loose teeth are in the form of kidney deficiency.
Example 1:
a traditional Chinese medicine toothpaste for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 30 parts of processed monkshood, 30 parts of halite, 20 parts of fructus psoraleae, 30 parts of gypsum and 10 parts of mint leaves.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 80 mesh sieve, adding 20 times of purified water, homogenizing under 0.25Mpa for 5min, sterilizing at 120 deg.C for 43 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 20 ℃, the fermentation humidity is 75%, and the fermentation time is 33 d. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 80 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 5 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is 60L/h, the temperature is 35 ℃, the pressure is 20MPa, each extraction time is 80min,obtaining volatile oil for later use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 7 times of purified water, carrying out reflux extraction for 3 times, each time for 30min, filtering, carrying out vacuum concentration, concentrating the liquid medicine to a specific gravity of 1.25 at a concentration temperature of 50 ℃ and a vacuum degree of-0.08 Mpa to obtain a concentrated solution, drying the concentrated solution to obtain dry paste, crushing the dry paste, and sieving the dry paste with a 80-mesh sieve to obtain dry paste powder for later use;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into toothpaste.
Further, the auxiliary materials comprise sodium carboxymethylcellulose, propylene glycol, silicon dioxide, sodium lauroyl sarcosine, stannous fluoride, chlorophyll and honey.
Further, the preparation type is ointment.
Further, the loose and loose teeth are in the form of kidney deficiency.
Example 2:
a traditional Chinese medicine toothpaste for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 50 parts of processed monkshood, 50 parts of halite, 30 parts of fructus psoraleae, 40 parts of gypsum and 20 parts of mint leaves.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 100 mesh sieve, adding 5 times of purified water, homogenizing under 0.35Mpa for 10min, sterilizing at 100 deg.C for 55 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 30 ℃, the fermentation humidity is 45%, and the fermentation time is 45 d. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 100 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 5 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is set to be 20L/h, the temperature is 37 ℃, the pressure is 70MPa, and the extraction time is 30min each time to obtain volatile oil for later use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 8 times of purified water, carrying out reflux extraction for 3 times, each time for 30min, filtering, carrying out vacuum concentration, concentrating the liquid medicine to obtain concentrated solution, drying the concentrated solution to obtain dry paste, crushing the dry paste, and sieving the dry paste with a 100-mesh sieve to obtain dry paste powder for later use, wherein the vacuum degree of the concentration is-0.1 Mpa, and the concentration temperature is 75 ℃;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into toothpaste.
Further, the auxiliary materials comprise sodium carboxymethylcellulose, propylene glycol, silicon dioxide, sodium lauroyl sarcosine, stannous fluoride, chlorophyll and honey.
Further, the preparation type is ointment.
Further, the loose and loose teeth are in the form of kidney deficiency.
Example 3:
a traditional Chinese medicine toothpaste for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 80 parts of processed monkshood, 80 parts of halite, 50 parts of fructus psoraleae, 80 parts of gypsum and 30 parts of mint leaves.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 100 mesh sieve, adding 13 times of purified water, homogenizing under 0.15Mpa for 15min, sterilizing at 110 deg.C for 30 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 40 ℃, the fermentation humidity is 60%, and the fermentation time is 20 days. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 200 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 7 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is 40L/h, the temperature is 32 deg.C, the pressure is 70MPa, and the extraction time is 55min each time to obtain volatile oil for use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 10 times of purified water, carrying out reflux extraction for 3 times, 40min each time, filtering, carrying out vacuum concentration, wherein the vacuum degree of concentration is-0.05 Mpa, the concentration temperature is 100 ℃, concentrating the liquid medicine to the specific gravity of 1.13 to obtain concentrated solution, drying to obtain dry paste, crushing, and sieving by a 130-mesh sieve to obtain dry paste powder for later use;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into toothpaste.
Further, the auxiliary materials comprise sodium carboxymethylcellulose, propylene glycol, silicon dioxide, sodium lauroyl sarcosine, stannous fluoride, chlorophyll and honey.
Further, the preparation type is ointment.
Further, the loose and loose teeth are in the form of kidney deficiency.
The reliability and safety of the traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and loose teeth and the falling teeth produced in the embodiment 1 to the embodiment 3 of the invention completely meet the requirements of the national relevant standards through detection, and the clinical treatment examples are as follows:
although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The traditional Chinese medicine toothpaste for treating the deficiency of the kidney type loose and loose teeth and falling off is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves.
2. The traditional Chinese medicine toothpaste for treating kidney deficiency type teeth floating and falling off according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 30-80 parts of radix aconiti praeparata, 30-80 parts of halitum, 30-60 parts of fructus psoraleae, 30-80 parts of gypsum and 15-35 parts of mint leaves.
3. The preparation method of the traditional Chinese medicine toothpaste for treating kidney deficiency type teeth loosening and falling off according to claim 2, which is characterized by comprising the following steps: the method comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into toothpaste;
the mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieving mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
4. The preparation method of the traditional Chinese medicine toothpaste for treating kidney deficiency type teeth loosening and falling off according to claim 3, which is characterized by comprising the following steps: the mass ratio of the processed aconite powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilizing temperature is 110 ℃, the sterilizing time is 43min, the inoculated strain is trametes cinnabarinus, the fermenting temperature is 30 ℃, the fermenting humidity is 60%, the fermenting time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
5. The preparation method of the traditional Chinese medicine toothpaste for treating kidney deficiency type teeth loosening and falling off according to claim 3, which is characterized by comprising the following steps: the adjuvants include sodium carboxymethylcellulose, propylene glycol, silicon dioxide, sodium lauroyl sarcosine, stannous fluoride, chlorophyll and Mel.
6. The preparation method of the traditional Chinese medicine toothpaste for treating kidney deficiency type teeth loosening and falling off according to claim 3, which is characterized by comprising the following steps: the preparation type is ointment.
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